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https://www.readbyqxmd.com/read/28806498/pacinian-corpuscles-in-human-lymph-nodes
#1
J Feito, J L Cobo, A Santos-Briz, J A Vega
The occurrence of Pacinian corpuscles associated to lymph nodes is an anatomical rarity and very scarce information exists in this regard. Here we examined immunohistochemically four Pacinian corpuscles found in the close vicinity of the hiliar blood vessels of lymph nodes (2 cervical, 1 axillary, and 1 inguinal) during routine surgical pathology. Pacinian corpuscles were normally arranged and displayed a pattern of protein distribution as follows: the axon was positive for neurofilament proteins and neuron specific enolase, the inner core cells showed intense S100 protein and vimentin immunostaining while they were negative for glial fibrillary acidic protein, type IV collagen and glucose transporter 1; vimentin, type IV collagen, and glucose transporter 1 were also observed also in the outer-core and the capsule...
August 14, 2017: Anatomical Record: Advances in Integrative Anatomy and Evolutionary Biology
https://www.readbyqxmd.com/read/28805947/penile-neurovascular-structure-revisited-immunohistochemical-studies-with-three-dimensional-reconstruction
#2
G N Yin, S-H Park, M-J Choi, A Limanjaya, K Ghatak, N N Minh, J Ock, K-M Song, J-K Ryu, J-K Suh
Penile erection is a neurovascular phenomenon that requires well coordinated and functional interaction between penile vascular and nervous systems. In order to provide a useful tool to examine pathologic changes in the erectile tissue, mainly focusing on penile neurovascular dysfunction, we established the technique to determine the differential distribution of endothelial cells, smooth muscle cells, pericytes, and nerve fibers in the mouse penis using immunohistochemical staining with three-dimensional reconstruction...
August 14, 2017: Andrology
https://www.readbyqxmd.com/read/28802567/nano-sized-and-other-improved-reporters-for-magnetic-resonance-imaging-of-angiogenesis
#3
Simonetta Geninatti Crich, Enzo Terreno, Silvio Aime
Magnetic Resonance Imaging (MRI) enables to provide anatomical, functional and molecular information of pathological angiogenesis when used with properly tailored imaging probes. Functional studies have been the domain of Dynamic Contrast Enhancement (DCE) -MRI protocols from which it is possible to extract quantitative estimations on key parameters such as the volumes of vascular and extracellular compartments and the rates of the bidirectional exchange of the imaging reporters across the endothelial barrier...
August 9, 2017: Advanced Drug Delivery Reviews
https://www.readbyqxmd.com/read/28795999/the-utility-of-immunohistochemistry-in-mycobacterial-infection-a-proposal-for-multimodality-testing
#4
Isaac H Solomon, Melanie E Johncilla, Jason L Hornick, Danny A Milner
Mycobacterium species are slow growing bacteria that cause significant morbidity and mortality worldwide. Because of the relative rarity of mycobacterial infections, potential for detection of nonpathogenic environmental contaminants, and substantial costs associated with molecular diagnostics, effective screening methods are needed to identify samples most suitable for molecular testing. While anatomic pathology specimens can be utilized to identify characteristic histologic inflammatory patterns and to directly visualize mycobacteria through histochemical (acid fast bacilli [AFB]) stains, the utility of immunohistochemistry (IHC) in this setting is unknown...
August 8, 2017: American Journal of Surgical Pathology
https://www.readbyqxmd.com/read/28795033/no-adverse-outcomes-of-video-assisted-thoracoscopic-surgery-resection-of-ct2-non-small-cell-lung-cancer-during-the-learning-curve-period
#5
Zeynep Bilgi, Hasan Fevzi Batırel, Bedrettin Yıldızeli, Korkut Bostancı, Tunç Laçin, Mustafa Yüksel
BACKGROUND: Video-assisted thoracoscopic surgery (VATS) anatomic lung resections are gradually becoming the standard surgical approach in early-stage non-small cell lung cancer (NSCLC). The technique is being applied in cases of larger tumors depending on the experience of the surgical team. The objective of this study was to compare early surgical and survival outcomes in patients undergoing anatomic pulmonary resections using VATS and thoracotomy techniques for clinical T2 NSCLC during the adaptation period of the surgical team to the VATS approach...
August 2017: Korean Journal of Thoracic and Cardiovascular Surgery
https://www.readbyqxmd.com/read/28795010/evaluation-and-management-of-knee-pain-in-young-athletes-overuse-injuries-of-the-knee
#6
REVIEW
Dilip R Patel, Ana Villalobos
Recurrent or chronic activity related knee pain is common in young athletes. Numerous intrinsic conditions affecting the knee can cause such pain. In addition, knee pain can be referred pain from low back, hip or pelvic pathology. The most common cause of knee pain in young athletes is patellofemoral pain syndrome, or more appropriately termed idiopathic anterior knee pain. Although, numerous anatomical and biomechanical factors have been postulated to contribute the knee pain in young athletes, the most common underlying reason is overuse injury...
July 2017: Translational pediatrics
https://www.readbyqxmd.com/read/28791481/anterior-transarticular-c1-c2-fixation-with-contralateral-screw-insertion-a-report-of-two-cases-and-technical-note
#7
Ivan Lvov, Andrey Grin, Aleksandr Kaykov, Vladimir Smirnov, Vladimir Krylov
PURPOSE: Anterior transarticular fixation of the C1-C2 vertebrae is a well-known technique that involves screw insertion through the body of the C2 vertebra into the lateral masses of the atlas through an anterior transcervical approach. Meanwhile, contralateral screw insertion has been previously described only in anatomical studies. METHODS: We describe two case reports of the clinical application of this new technique. RESULTS: In Case 1, the patient was diagnosed with an unstable C1 fracture...
August 8, 2017: European Spine Journal
https://www.readbyqxmd.com/read/28791352/establishment-of-a-murine-pancreatic-cancer-pain-model-and-microarray-analysis-of-pain%C3%A2-associated-genes-in-the-spinal-cord-dorsal-horn
#8
Liqin Wang, Huihong Xu, Yanhu Ge, Hai Zhu, Dawei Yu, Weifeng Yu, Zhijie Lu
There is emerging evidence on the mechanisms of pancreatic cancer pain. Following the establishment of an orthotropic transplantation model of pancreatic cancer, microarray analysis was performed to identify changes in the expression levels of pain‑associated genes in the spinal cord. A mouse model of pancreatic cancer‑induced pain was established by implanting SW 1990 cells into the pancreases of female BALB/c‑nu mice. The survival rate and body weight were measured following orthotropic transplantation...
August 4, 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/28781148/the-role-of-imaging-in-the-diagnosis-of-bronchiectasis-the-key-is-in-the-distribution
#9
J Bueno, L Flors
Diseases that involve the medium caliber airways (segmental and subsegmental bronchi) are common and present clinically with nonspecific respiratory symptoms such as cough, recurrent respiratory infections and occasionally, hemoptysis. The abnormal and irreversible dilation of bronchi is known as "bronchiectasis". The diagnosis can be challenging and the analysis of the regional distribution of the bronchiectasis is the most useful diagnostic guide. The objective of this manuscript is to describe the main imaging findings of bronchiectasis and their classification, review the diseases that most commonly present with this abnormality, and provide an approach to the diagnosis based on their imaging appearance and anatomic distribution...
August 3, 2017: Radiología
https://www.readbyqxmd.com/read/28780516/diagnosis-of-endocrine-disease-primary-empty-sella-a-comprehensive-review
#10
Sabrina Chiloiro, Antonella Giampietro, Antonio Bianchi, Tommaso Tartaglione, Antonio Capobianco, Carmelo Anile, Laura De Marinis
Primary empty sella (PES) is characterized by the herniation of the subarachnoid space within the sella, which is often associated with variable degree of flattening of the pituitary gland in patients without previous pituitary pathologies. PES pathogenetic mechanism are not well known but seem due to a sellar diaphragm incompetence, associated to the occurrence of upper sellar or pituitary factors, as intracranial hypertension and change of pituitary volume. As PES represents in majority of cases a neuroradiological findings, without any clinical implication, the occurrence of endocrine, neurological and opthalmological symptoms, due to the above describes anatomical alteration, delineates the so called PES syndrome...
August 5, 2017: European Journal of Endocrinology
https://www.readbyqxmd.com/read/28779881/pediatric-skeletal-scintigraphy-what-a-general-radiologist-needs-to-know
#11
Fathima Fijula Palot Manzil, Jon Baldwin, Asim Kumar Bag
Pediatric skeletal scintigraphy is a noninvasive imaging modality which aids in functional as well as anatomic evaluation of bone. Bone scintigraphy plays a major role in diagnosis and evaluation of various benign, primary malignant and metastatic pediatric bone pathologies. The advantage of bone scan is that it becomes positive well before the bone pathology is evident on radiographs and specifically the entire skeleton can be imaged in a single examination. Pediatric bone scintigraphy evaluation can be challenging to the general radiologist not routinely exposed to the study, as the growing skeleton is quite different from a mature skeleton especially at or near the growth plates...
July 8, 2017: Current Problems in Diagnostic Radiology
https://www.readbyqxmd.com/read/28777893/age-related-vascularization-and-ossification-of-joints-in-children-an-international-pilot-study-to-test-multi-observer-ultrasound-reliability
#12
Daniel Windschall, Paz Collado, Jelena Vojinovic, Silvia Magni-Manzoni, Peter Balint, George A W Bruyn, Cristina Hernandez-Diaz, Juan Carlos Nieto, Viviana Ravagnani, Nikolay Tzaribachev, Annamaria Iagnocco, Maria Antonietta D'Agostino, Esperanza Naredo
OBJECTIVE: To determine the intra- and inter-observer reliability of ultrasound (US)-detected age-related joint vascularization and ossification grading in healthy children. METHODS: Following standardized image acquisition and machine setting protocols, 10 international US experts examined four joints (wrist, second metacarpophalangeal joint, knee, and ankle) in 12 healthy children (divided into four age groups: 2-4, 5-8, 9-12, and 13-16 years). Grey-scale was used to detect the ossification grade, and power Doppler (PD) US was used to detect physiological vascularization...
August 4, 2017: Arthritis Care & Research
https://www.readbyqxmd.com/read/28777699/multidetector-ct-for-evaluation-of-the-extrapleural-space
#13
Mario G Santamarina, Ignacio Beddings, Guillermo V Lermanda Holmgren, Hector Opazo Sanchez, Mariano M Volpacchio
The extrapleural space (EPS) is an anatomic space at the periphery of the chest that can be involved in a number of disease processes. This space lies between the inner surface of the ribs and the parietal pleura and contains adipose tissue, loose connective tissue, lymph nodes, vessels, endothoracic fascia, and the innermost intercostal muscle. It is often overlooked on cross-sectional imaging studies and almost invariably overlooked on conventional radiographic studies. At conventional radiography, the EPS occasionally can be seen when there is extrapleural fat proliferation, which might be confused with pleural thickening or pleural effusion...
August 4, 2017: Radiographics: a Review Publication of the Radiological Society of North America, Inc
https://www.readbyqxmd.com/read/28777219/anterior-glenohumeral-instability
#14
Adam Pickett, Steven Svoboda
Anterior shoulder dislocations, subluxations, and recurrent instability of the shoulder joint are common problems usually affecting a young active population. However, it can be a problem for patients up to the late decades in life and can lead to major shoulder arthropathy if left untreated or improperly treated. This article discusses the natural history, pathologic morphologic changes of the shoulder joint associated with anterior instability along with normal anatomic variants. We will also discuss current treatment recommendations and possible causes of the patient with recurrent instability despite prior stabilization procedures...
September 2017: Sports Medicine and Arthroscopy Review
https://www.readbyqxmd.com/read/28776665/morphology-topology-and-dimensions-of-the-heart-and-arteries-of-genetically-normal-and-mutant-mouse-embryos-at-stages-s21-s23
#15
Stefan H Geyer, Lukas F Reissig, Markus Hüsemann, Cordula Höfle, Robert Wilson, Fabrice Prin, Dorota Szumska, Antonella Galli, David J Adams, Jacqui White, Timothy J Mohun, Wolfgang J Weninger
Accurate identification of abnormalities in the mouse embryo depends not only on comparisons with appropriate, developmental stage-matched controls, but also on an appreciation of the range of anatomical variation that can be expected during normal development. Here we present a morphological, topological and metric analysis of the heart and arteries of mouse embryos harvested on embryonic day (E)14.5, based on digital volume data of whole embryos analysed by high-resolution episcopic microscopy (HREM). By comparing data from 206 genetically normal embryos, we have analysed the range and frequency of normal anatomical variations in the heart and major arteries across Theiler stages S21-S23...
August 3, 2017: Journal of Anatomy
https://www.readbyqxmd.com/read/28776326/a-comprehensive-pipeline-for-multi-resolution-modeling-of-the-mitral-valve-validation-computational-efficiency-and-predictive-capability
#16
Andrew Drach, Amir H Khalighi, Michael S Sacks
Multiple studies have demonstrated that the pathological geometries unique to each patient can affect the durability of mitral valve (MV) repairs. While computational modeling of the MV is a promising approach to improve the surgical outcomes, the complex MV geometry precludes use of simplified models. Moreover, the lack of complete in-vivo geometric information presents significant challenges in the development of patient-specific computational models. There is thus a need to determine the level of detail necessary for predictive MV models...
August 3, 2017: International Journal for Numerical Methods in Biomedical Engineering
https://www.readbyqxmd.com/read/28775383/high-resolution-3-dimensional-imaging-of-the-human-cardiac-conduction-system-from-microanatomy-to-mathematical-modeling
#17
Robert S Stephenson, Andrew Atkinson, Petros Kottas, Filip Perde, Fatemeh Jafarzadeh, Mike Bateman, Paul A Iaizzo, Jichao Zhao, Henggui Zhang, Robert H Anderson, Jonathan C Jarvis, Halina Dobrzynski
Cardiac arrhythmias and conduction disturbances are accompanied by structural remodelling of the specialised cardiomyocytes known collectively as the cardiac conduction system. Here, using contrast enhanced micro-computed tomography, we present, in attitudinally appropriate fashion, the first 3-dimensional representations of the cardiac conduction system within the intact human heart. We show that cardiomyocyte orientation can be extracted from these datasets at spatial resolutions approaching the single cell...
August 3, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28774693/characterizing-the-skull-base-in-craniofacial-microsomia-using-principal-component-analysis
#18
S C Schaal, C Ruff, B I Pluijmers, E Pauws, C W N Looman, M J Koudstaal, D J Dunaway
The aim of this study was to compare the anatomical differences in the skull base between the affected and non-affected side in patients with craniofacial microsomia (CFM), and to compare the affected and non-affected sides with measurements from a normal population. Three-dimensional computed tomography scans of 13 patients with unilateral CFM and 19 normal patients (age range 7-12 years) were marked manually with reliable homologous landmarks. Principal component analysis (PCA), as part of a point distribution model (PDM), was used to analyse the variability within the normal and preoperative CFM patient groups...
July 31, 2017: International Journal of Oral and Maxillofacial Surgery
https://www.readbyqxmd.com/read/28774256/anatomical-variations-of-the-extensor-carpi-ulnaris-groove-a-new-computed-tomography-based-evaluation
#19
Sho Kohyama, Toshikazu Tanaka, Eriko Okano, Ochiai Naoyuki
BACKGROUND: This study aimed to develop a classification that precisely describes the extensor carpi ulnaris (ECU) groove morphology. METHODS: Reconstructed axial plane computed tomography scans of the wrists of 200 patients were reviewed. Three groups of groove shape were created based on the position of the deepest point: deviated to the ulnar side (Type U), in the middle of the groove (Type M), and deviated to the radial side (Type R). Groove depth, width, carrying angle, and radius of the curvature were measured using the Picture Archiving and Communication System in a slice in which the ulnar head was the largest...
September 2017: Journal of Hand Surgery Asian-Pacific Volume
https://www.readbyqxmd.com/read/28770271/-r1-resection-of-esophageal-carcinoma
#20
REVIEW
I Gockel, C Wittekind
The microscopic identification of residual tumor tissue in the oral or aboral resection margins (R1 resection) of esophageal specimens following oncologic esophageal resection, increases the risk of tumor recurrence and disease-related morbidity. Esophageal resection with its associated risks is only meaningful, if an R0 situation can be safely achieved. The relevance of microscopic involvement of the circumferential resection margin (CRM) in esophageal carcinoma in its different definitions by the British and the American Societies of Pathology has up to now never been investigated in a prospective study...
August 2, 2017: Der Chirurg; Zeitschrift Für Alle Gebiete der Operativen Medizen
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