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Anatomic pathology

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https://www.readbyqxmd.com/read/29145401/anatomically-specific-intratubular-and-interstitial-biominerals-in-the-human-renal-medullo-papillary-complex
#1
Ling Chen, Ryan S Hsi, Feifei Yang, Benjamin A Sherer, Marshall L Stoller, Sunita P Ho
Limited information exists on the anatomically-specific early stage events leading to clinically detectable mineral aggregates in the renal papilla. In this study, quantitative multiscale correlative maps of structural, elemental and biochemical properties of whole medullo-papillary complexes from human kidneys were developed. Correlative maps of properties specific to the uriniferous and vascular tubules using high-resolution X-ray computed tomography, scanning and transmission electron microscopy, energy dispersive X-ray spectroscopy, and immunolocalization of noncollagenous proteins (NCPs) along with their association with anatomy specific biominerals were obtained...
2017: PloS One
https://www.readbyqxmd.com/read/29143961/upregulation-of-epidermal-gap-junctional-proteins-in-patients-with-venous-disease
#2
M Kanapathy, R Simpson, L Madden, C Thrasivoulou, A Mosahebi, D L Becker, T Richards
BACKGROUND: Leg ulceration is a feared complication of venous insufficiency. It is not known whether varicose veins predispose skin to poor wound healing. The expression pattern of gap junctional protein connexin, a known marker of poor wound healing, was investigated across various stages of venous disease. METHODS: Patients undergoing intervention for varicose veins were assessed according to the Clinical Etiologic Anatomic Pathophysiologic (CEAP) classification of varicose veins...
November 16, 2017: British Journal of Surgery
https://www.readbyqxmd.com/read/29143113/percutaneous-ct-guided-sacroiliac-joint-sampling-for-infection-aspiration-biopsy-and-technique
#3
David Knipp, F Joseph Simeone, Sandra B Nelson, Ambrose J Huang, Connie Y Chang
OBJECTIVE: To evaluate methods of CT-guided sacroiliac joint sampling in patients with suspected infection. MATERIALS AND METHODS: All CT-guided sacroiliac joint sampling procedures for suspected infection were reviewed for sampling type (aspiration, lavage aspiration, biopsy), microbiology results, and clinical and imaging follow-up. The primary gold standard was anatomic pathology. If pathology was not available, then positive blood culture with the same organism as SIJ sampling, imaging and clinical follow-up, or clinical follow-up only were used...
November 15, 2017: Skeletal Radiology
https://www.readbyqxmd.com/read/29141778/pathophysiology-and-risk-of-atrial-fibrillation-detected-after-ischemic-stroke-paradise-a-translational-integrated-and-transdisciplinary-approach
#4
Maryse Paquet, Joshua O Cerasuolo, Victoria Thorburn, Sebastian Fridman, Rasha Alsubaie, Renato D Lopes, Lauren E Cipriano, Paula Salamone, C W James Melling, Ali R Khan, Lucas Sedeño, Jiming Fang, Maria Drangova, Manuel Montero-Odasso, Jennifer Mandzia, Alexander V Khaw, Juan M Racosta, Justin Paturel, Lucy Samoilov, Devin Stirling, Brittany Balint, Victoria Jaremek, Marlys L Koschinsky, Michael B Boffa, Kelly Summers, Agustín Ibañez, Marko Mrkobrada, Gustavo Saposnik, Kurt Kimpinski, Shawn N Whitehead, Luciano A Sposato
BACKGROUND: It has been hypothesized that ischemic stroke can cause atrial fibrillation. By elucidating the mechanisms of neurogenically mediated paroxysmal atrial fibrillation, novel therapeutic strategies could be developed to prevent atrial fibrillation occurrence and perpetuation after stroke. This could result in fewer recurrent strokes and deaths, a reduction or delay in dementia onset, and in the lessening of the functional, structural, and metabolic consequences of atrial fibrillation on the heart...
November 13, 2017: Journal of Stroke and Cerebrovascular Diseases: the Official Journal of National Stroke Association
https://www.readbyqxmd.com/read/29140404/evaluation-of-opportunities-to-improve-hematopathology-diagnosis-for-vietnam-pathologists
#5
Vanessa Dayton, Chi Kim Nguyen, Trinh Thu Van, Nguyen Van Thanh, Ta Van To, Nguyen Phi Hung, Nguyen Ngoc Dung, Danny A Milner
Objectives: We evaluate the need for, feasibility of, and impediments to improving hematopathology diagnoses for cancer hospitals in Vietnam. Methods: Two hematopathologists from the United States visited three major cancer treatment hospitals in Vietnam to workshop a sampling of difficult hematopathology cases. With Vietnamese pathologists, they toured histopathology, immunohistochemistry, and ancillary laboratory facilities. Results: Automated tissue processors and slide staining equipment were documented for each of the three hospitals...
November 11, 2017: American Journal of Clinical Pathology
https://www.readbyqxmd.com/read/29138745/spontaneous-nervous-system-concussion-in-dogs-a-description-of-two-cases-and-a-review-of-terminology-in-veterinary-medicine
#6
Angelo Pasquale Giannuzzi, Antonio De Simone, Mario Ricciardi
In human medicine, central nervous system (CNS) concussion is defined as a transient neurological dysfunction following a traumatic event, without evidence of structural abnormalities of the affected region on advanced diagnostic imaging. Depending on the anatomical region involved, three forms of concussive syndromes are described: brain concussion, spinal concussion and cerebellar concussion. Although major textbooks of veterinary neurology admit the existence of canine brain concussion, spontaneous cases of this pathological condition have not been reported in small animals so far...
2017: Open veterinary journal
https://www.readbyqxmd.com/read/29138072/preoperative-assessment-of-craniopharyngioma-adherence-mri-findings-correlated-with-the-severity-of-tumor-attachment-to-the-hypothalamus
#7
Ruth Prieto, José M Pascual, Maria Rosdolsky, Laura Barrios
BACKGROUND: Craniopharyngioma (CP) adherence represents a heterogeneous pathological feature that critically influences the potentially safe and radical resection. OBJECTIVE: To define the MRI predictors of CP adherence severity. METHODS: This study retrospectively investigated a cohort of 200 surgically treated CPs with their corresponding preoperative conventional MRI scans. MRI findings related to the distortions of anatomical structures along the sella turcica-third ventricle axis caused by CPs, in addition to the tumor's shape and calcifications were analyzed and correlated with the definitive type of CP adherence observed during the surgical procedures...
November 11, 2017: World Neurosurgery
https://www.readbyqxmd.com/read/29137915/first-line-direct-access-for-transarterial-embolization-of-a-dural-arteriovenous-fistula-case-report-and-literature-review
#8
Brent J Doolan, Iddo Paldor, Peter J Mitchell, Andrew P Morokoff
Intracranial dural arteriovenous fistulae (DAVF) are complex vascular malformations consisting of a pathological shunt located between meningeal arteries and drainage to dural venous sinuses and/or cerebral veins. We report an unusual anatomical variation, resulting in a DAVF forming between the superior sagittal sinus and an anomalous origin of the middle meningeal artery (MMA) arising from the left ophthalmic artery. We present an atypical case requiring mini-craniotomy for catheter access, as well as cannulation of extracranial arterial supply prior to embolization of a Cognard type IIa+b fistula...
November 11, 2017: Journal of Clinical Neuroscience: Official Journal of the Neurosurgical Society of Australasia
https://www.readbyqxmd.com/read/29136642/common-and-distinct-structural-features-of-schizophrenia-and-bipolar-disorder-the-european-network-on-psychosis-affective-disorders-and-cognitive-trajectory-enpact-study
#9
Eleonora Maggioni, Benedicto Crespo-Facorro, Igor Nenadic, Francesco Benedetti, Christian Gaser, Heinrich Sauer, Roberto Roiz-Santiañez, Sara Poletti, Veronica Marinelli, Marcella Bellani, Cinzia Perlini, Mirella Ruggeri, A Carlo Altamura, Vaibhav A Diwadkar, Paolo Brambilla
INTRODUCTION: Although schizophrenia (SCZ) and bipolar disorder (BD) share elements of pathology, their neural underpinnings are still under investigation. Here, structural Magnetic Resonance Imaging (MRI) data collected from a large sample of BD and SCZ patients and healthy controls (HC) were analyzed in terms of gray matter volume (GMV) using both voxel based morphometry (VBM) and a region of interest (ROI) approach. METHODS: The analysis was conducted on two datasets, Dataset1 (802 subjects: 243 SCZ, 176 BD, 383 HC) and Dataset2, a homogeneous subset of Dataset1 (301 subjects: 107 HC, 85 BD and 109 SCZ)...
2017: PloS One
https://www.readbyqxmd.com/read/29134368/-patellofemoral-instability
#10
S F Fucentese
Patellofemoral instability is an extremely limiting pathology in young and active patients. Anatomical reasons for patellar instability, such as high-riding patella, elevated distance from the tibial tuberosity to trochlear groove (TTTG), trochlear dysplasia, insufficient medial patellofemoral ligament (MPFL) and malpositioning of the axes and torsion can lead to chronic patellofemoral instability and must be thoroughly analyzed. The first dislocation can be treated conservatively, with the exception of an osteochondral defect...
November 13, 2017: Der Orthopäde
https://www.readbyqxmd.com/read/29134172/posterior-nutcracker-phenomenon-in-a-patient-with-left-atrial-isomerism
#11
Stanislav Tsvelodub, Léon M Putman, Andrea Gieselmann, Hans-Hinrich Sievers
Background  Nutcracker phenomenon (NCP) can occur due to various anatomical anomalies. Anterior and posterior NCP are defined in the literature. Posterior NCP combined with left atrial isomerism is a rare condition. Case description  We present a rare case of an asymptomatic posterior NCP involving the azygos vein in a patient with a complex cardiovascular pathology with left atrial isomerism, left ventricular outflow tract obstruction, interrupted inferior vena cava, and azygos continuation. Conclusion  Detection of the NCP especially involving such a rare anatomical anomaly as an azygos continuation has a crucial importance for diagnostic and surgical procedures...
January 2017: Thoracic and Cardiovascular Surgeon Reports
https://www.readbyqxmd.com/read/29133062/anatomical-and-physiological-basis-of-continuous-spike-wave-of-sleep-syndrome-after-early-thalamic-lesions
#12
Alberto Leal, Eulália Calado, José P Vieira, Carla Mendonça, José C Ferreira, Hugo Ferreira, Daniel Carvalho, Fátima Furtado, Roseli Gomes, José P Monteiro
OBJECTIVE: Early neonatal thalamic lesions account for about 14% of continuous spike-wave of sleep (CSWS) syndrome, representing the most common etiology in this epileptic encephalopathy in children, and promise useful insights into the pathophysiology of the disease. METHODS: We describe nine patients with unilateral neonatal thalamic lesions which progressed to CSWS. Longitudinal whole-night and high-density electroencephalograms (EEGs) were performed, as well as detailed imaging and clinical evaluation...
November 10, 2017: Epilepsy & Behavior: E&B
https://www.readbyqxmd.com/read/29132118/primary-malignant-melanoma-of-the-female-urethra-report-of-a-rare-neoplasm-of-the-urinary-tract
#13
Namita Bhutani, Pradeep Kajal, Devendra Pawar
INTRODUCTION: Melanoma is a malignant tumor that can affect any area of the anatomical economy. Its occurance in the female urethra is extremely rare. We report a case of primary malignant urethral melanoma developed in an elderly female patient. PRESENTATION OF CASE: A 70 years old female presented with dysuria, poor stream, gross haematuria, intermittent blood spots, and a painful mass. On physical examination, there were no suspicious lesions on the skin. On external genital examination, a lesion at the level of the urethral meatus was observed...
November 8, 2017: International Journal of Surgery Case Reports
https://www.readbyqxmd.com/read/29131279/electron-microscope-study-of-the-advanced-tendinopathy-process-of-the-long-head-of-the-biceps-brachii-tendon-treated-arthroscopically
#14
Jan Zabrzyński, Maciej Gagat, Łukasz Paczesny, Łukasz Łapaj, Dariusz Grzanka
BACKGROUND: The ultrastructural alterations related to tendinopathy have not been well described. Most studies on this subject have been conducted many years ago and focused on material from the Achilles tendon. It was demonstrated that various comorbidities can affect ultrastructural alterations in the advanced tendinopathy, however there is very little data on ultrastructural morphology in tendinopathies related to mechanical overload as in case of the long head of the biceps brachii tendon (LHBT)...
November 13, 2017: Folia Morphologica (Warsz)
https://www.readbyqxmd.com/read/29130878/a-novel-technique-utilizing-a-vastus-lateralis-anchor-in-treatment-of-chronic-patellar-dislocation-after-total-knee-arthroplasty
#15
Allison Mayfield, Vamsi Singaraju, Afshin A Anoushiravani, Zain Sayeed, Jamal K Saleh, Khaled J Saleh
Extensor mechanism complications involving the patella frequently result in total knee arthroplasty (TKA) failure. Postoperative patellar dislocation may be caused by soft tissue imbalance, improper sizing, and position of the prosthesis. This report describes a case of revision TKA requiring several rounds of soft tissue releases in an effort to treat the patient's chronic patellar dislocation. In the process, a novel surgical approach was developed for the surgical management of refractory chronic patellar dislocations...
October 2017: Journal of Surgical Orthopaedic Advances
https://www.readbyqxmd.com/read/29129414/-surgical-management-of-deep-infiltrating-endometriosis-with-bowel-involvement-and-urinary-tract-involvement
#16
Sofiane Bendifallah, Marcos Ballester, Emile Darai
Endometriosis is a benign pathology that affects 3% of the general population and about 10% of women of reproductive age. Three anatomoclinical entities are described: peritoneal, ovarian (endometrioma) and deep endometriosis characterized by the infiltration of anatomical structures or organs beyond the peritoneum. Laparoscopic surgery should be performed, as this is associated with a reduction in postoperative complications, length of hospitalization and convalescence. Several surgical techniques allow the removal of deep endometriosis with colorectal involvement: rectal shaving, anterior discoid resection, segmental resection...
November 9, 2017: La Presse Médicale
https://www.readbyqxmd.com/read/29129409/-fertility-and-deep-infiltrating-endometriosis
#17
Jonathan Cohen, Emmanuelle Mathieu d'Argent, Lise Selleret, Jean-Marie Antoine, Nathalie Chabbert-Buffet, Sofiane Bendifallah, Marcos Ballester, Emile Darai
Deep infiltrating endometriosis is the most severe form of the disease, defined by infiltration beneath the peritoneum greater than 5mm. It affects several anatomical locations including the bladder, the vesico-uterine cul-de-sac, the torus uterinum, the uterosacral ligament, rectovaginal septum and the colon-rectum. Deep infiltrating endometriosis is associated with infertility. Surgery performed for deep infiltrating endometriosis in the context of pain offers good pregnancy rates either spontaneously or after assisted reproductive technologies...
November 9, 2017: La Presse Médicale
https://www.readbyqxmd.com/read/29129357/in-situ-neoplasia-in-lymph-node-pathology
#18
REVIEW
Naoki Oishi, Santiago Montes-Moreno, Andrew L Feldman
In situ neoplasia represents the earliest form of malignant progression and is characterized by localization limited to the compartment corresponding to the cell of origin. Like other cancers, lymphoid neoplasms are considered to develop by multistep pathogenetic mechanisms. However, because of the circulating nature of lymphocytes, in situ lymphoid neoplasia may be difficult to identify histopathologically, and the compartment to which it is restricted may be physiological rather than strictly anatomical. The 2016 WHO classification of lymphoid neoplasms recognizes two in situ entities: in situ follicular neoplasia (ISFN) and in situ mantle cell neoplasia (ISMCN)...
November 9, 2017: Seminars in Diagnostic Pathology
https://www.readbyqxmd.com/read/29128577/pathological-and-3-tesla-volumetric-mr-predictors-of-biochemical-recurrence-after-robotic-assisted-radical-prostatectomy-correlation-with-whole-mount-histopathology
#19
Nelly Tan, Luyao Shen, Pooria Khoshnoodi, Héctor E Alcalá, Weixia Yu, William Hsu, Robert E Reiter, David Y Lu, Steven S Raman
OBJECTIVE: To identify the clinical and MRI variables predictive of biochemical recurrence (BCR) after robotic assisted radical prostatectomy (RALP) in patients who underwent multi-parametric 3 Tesla prostate MR Imaging. METHODS: An IRB approved, HIPAA compliant, a single arm observational study with 3T mpMRI prior to RALP from December 2009 until March 2016 was performed. Clinical, MRI, pathological information and clinical outcome were compiled. Biochemical recurrence was defined as PSA greater > 0...
November 8, 2017: Journal of Urology
https://www.readbyqxmd.com/read/29127999/high-resolution-isotropic-three-dimensional-mr-imaging-of-the-extraforaminal-segments-of-the-cranial-nerves
#20
REVIEW
Jessica Wen, Naman S Desai, Dean Jeffery, Nafi Aygun, Ari Blitz
High-resolution isotropic 3-dimensional (D) MR imaging with and without contrast is now routinely used for imaging evaluation of cranial nerve anatomy and pathologic conditions. The anatomic details of the extraforaminal segments are well-visualized on these techniques. A wide range of pathologic entities may cause enhancement or displacement of the nerve, which is now visible to an extent not available on standard 2D imaging. This article highlights the anatomy of extraforaminal segments of the cranial nerves and uses select cases to illustrate the utility and power of these sequences, with a focus on constructive interference in steady-state...
February 2018: Magnetic Resonance Imaging Clinics of North America
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