keyword
https://read.qxmd.com/read/38547496/duration-of-sars-cov-2-shedding-a-systematic-review
#1
JOURNAL ARTICLE
Anouk M Oordt-Speets, Julia R Spinardi, Carlos F Mendoza, Jingyan Yang, Graciela Del Carmen Morales, Moe H Kyaw
BACKGROUND: Positive viral severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) cultures indicate shedding of infectious virus and corresponding transmission risk of coronavirus disease 2019 (COVID-19). The research question of this systematic review was: Is there a discernible pattern in the timing of SARS-CoV-2 virus isolation, and what is the proportion of positive and negative results for isolation of SARS-CoV-2 virus with viral culture relative to the onset of clinical symptoms or the day of diagnosis, as indicated by longitudinal studies? METHODS: We systematically searched PubMed and Embase from inception to 16 February 2023 for English-language studies with serial viral culture testing within symptomatic or asymptomatic SARS-CoV-2 infected persons during the post-vaccination period...
March 29, 2024: Journal of Global Health
https://read.qxmd.com/read/38547300/a-pilot-randomised-controlled-trial-comparing-the-effectiveness-of-the-materre180-participatory-tool-including-a-serious-game-versus-an-intervention-including-carbon-footprint-awareness-raising-on-behaviours-among-academia-members-in-france
#2
JOURNAL ARTICLE
Claudia Teran-Escobar, Nicolas Becu, Nicolas Champollion, Nicolas Gratiot, Benoît Hingray, Gérémy Panthou, Isabelle Ruin
BACKGROUND: Activities embedded in academic culture (international conferences, field missions) are an important source of greenhouse gas emissions. For this reason, collective efforts are still needed to lower the carbon footprint of Academia. Serious games are often used to promote ecological transition. Nevertheless, most evaluations of their effects focus on changes in knowledge and not on behaviour. The main objectives of this study are to 1) Evaluate the feasibility of a control and an experimental behaviour change intervention and, 2) Evaluate the fidelity (the extent to which the implementation of the study corresponds to the original design) of both interventions...
2024: PloS One
https://read.qxmd.com/read/38547234/transcriptome-wide-analysis-of-the-differences-between-mcf7-cells-cultured-in-dmem-or-%C3%AE-mem
#3
JOURNAL ARTICLE
Yang Jiao, Hongbo Zhao, Lin Lu, Xiangyu Zhao, Yanchun Wang, Bingrong Zheng
MCF7 cells have been used as an experimental model for breast cancer for decades. Typically, a culture medium is designed to supply cells with the nutrients essential for their continuous proliferation. Each medium has a specific nutritional composition. Therefore, cells cultured in different media may exhibit differences in their metabolism. However, only a few studies have investigated the effects of media on cells. In this study, we compared the effects of Dulbecco's modified Eagle medium (DMEM) and minimum essential medium alpha modification (αMEM) on MCF7 cells...
2024: PloS One
https://read.qxmd.com/read/38547218/rosiglitazone-alleviates-lps-induced-endometritis-via-suppression-of-tlr4-mediated-nf-%C3%AE%C2%BAb-activation
#4
JOURNAL ARTICLE
Hongchu Bao, Jianxiang Cong, Qinglan Qu, Shunzhi He, Dongmei Zhao, Huishan Zhao, Shuyuan Yin, Ding Ma
OBJECTIVE: The aim of this study was to investigate the anti-inflammatory effect of Rosiglitazone (RGZ) on lipopolysaccharide (LPS) -induced Endometritis and explore its possible mechanism. METHODS: The preventive and therapeutic effects of RGZ on Endometritis were studied in vivo and in vitro. A total of 40 female C57BL/6 mice were randomly divided into the following 4 groups: RGZ+LPS, RGZ control, LPS and DMSO control. The mice uterine tissue sections were performed with HE and immunohistochemical staining...
2024: PloS One
https://read.qxmd.com/read/38547143/quantitative-imaging-and-semiotic-phenotyping-of-mitochondrial-network-morphology-in-live-human-cells
#5
JOURNAL ARTICLE
Sophie Charrasse, Victor Racine, Charlotte Saint-Omer, Titouan Poquillon, Loïc Lionnard, Marine Ledru, Christophe Gonindard, Sandrine Delaunois, Karima Kissa, Richard E Frye, Manuela Pastore, Christelle Reynes, Mathilde Frechet, Hanane Chajra, Abdel Aouacheria
The importance of mitochondria in tissue homeostasis, stress responses and human diseases, combined to their ability to transition between various structural and functional states, makes them excellent organelles for monitoring cell health. There is therefore a need for technologies to accurately analyze and quantify changes in mitochondrial organization in a variety of cells and cellular contexts. Here we present an innovative computerized method that enables accurate, multiscale, fast and cost-effective analysis of mitochondrial shape and network architecture from confocal fluorescence images by providing more than thirty features...
2024: PloS One
https://read.qxmd.com/read/38547137/balancing-the-uncertain-and-unpredictable-nature-of-possible-zoonotic-disease-transmission-with-the-value-placed-on-animals-findings-from-a-qualitative-study-in-guinea
#6
JOURNAL ARTICLE
Tilly A Gurman, Kendela Diallo, Elizabeth Larson, Kathryn Sugg, Natalie Tibbels
Zoonoses, or diseases that pass between animals and humans, represent a major threat to global health and global economies. In Guinea, zoonotic diseases (e.g. rabies, Lassa fever) have been at the forefront due to recent outbreaks and government priorities. Much like many other diseases, zoonotic disease prevention demands a thorough and culturally nuanced understanding of the factors that influence preventive behaviors. To gain this knowledge and enhance risk communication for priority zoonotic diseases, this qualitative study conducted focus group discussions, in-depth interviews, and observations in three Guinean prefectures...
2024: PLOS Glob Public Health
https://read.qxmd.com/read/38547132/a-qualitative-inquiry-on-drivers-of-covid-19-vaccine-hesitancy-among-adults-in-kenya
#7
JOURNAL ARTICLE
Stacey Orangi, Daniel Mbuthia, Elwyn Chondo, Carol Ngunu, Evelyn Kabia, John Ojal, Edwine Barasa
COVID-19 vaccination rates have been low among adults in Kenya (36.7% as of late March 2023) with vaccine hesitancy posing a threat to the COVID-19 vaccination program. This study sought to examine facilitators and barriers to COVID-19 vaccinations in Kenya. We conducted a qualitative cross-sectional study in two purposively selected counties in Kenya. We collected data through 8 focus group discussions with 80 community members and 8 in-depth interviews with health care managers and providers. The data was analyzed using a framework approach focusing on determinants of vaccine hesitancy and their influence on psychological constructs...
2024: PLOS Glob Public Health
https://read.qxmd.com/read/38546975/insulin-transferrin-selenium-promote-formation-of-tissue-engineered-vascular-grafts-in-early-stage-of-culture
#8
JOURNAL ARTICLE
Xuheng Sun, Nannan Wang, Hongjing Jiang, Qing Liu, Cong Xiao, Jianyi Xu, Yindi Wu, Jingyi Mei, Shuting Wu, Zhanyi Lin
To create tissue-engineered vascular grafts (TEVGs) in vitro, vascular smooth muscle cells (VSMCs) must function effectively and produce sufficient extracellular matrix (ECM) in a three-dimensional space. In this study, we investigated whether the addition of insulin-transferrin-selenium (ITS), a medium supplement, could enhance TEVG formation. PGA fabric was used as the scaffold, and 1% ITS was added to the medium. After two weeks, the tissues were examined using electron microscopy and staining. The ITS group exhibited a denser structure and increased collagen production...
March 28, 2024: Preparative Biochemistry & Biotechnology
https://read.qxmd.com/read/38546946/assessing-culturally-tailored-dementia-interventions-to-support-informal-caregivers-of-people-living-with-dementia-plwd-a-scoping-review
#9
REVIEW
Araya Dimtsu Assfaw, Kerstin M Reinschmidt, Thomas A Teasdale, Lancer Stephens, Keith L Kleszynski, Kathleen Dwyer
The review aimed to identify and describe dementia care interventions and programs that are culturally tailored to support racial and ethnic minority informal caregivers of community-dwelling people living with dementia (PLWD) to identify gaps in need. Culturally targeted interventions to support vulnerable minority informal caregivers are important in addressing the care needs of PLWD and eliminating racial and ethnic dementia disparities. Nevertheless, little is known about the existing interventions and programs that are culturally tailored to support racial and ethnic minority groups, in particular, African-American caregivers in the care of their family members...
March 28, 2024: Journal of Racial and Ethnic Health Disparities
https://read.qxmd.com/read/38546876/glucosylglycerol-and-proline-reverse-the-effects-of-glucose-on-rhodosporidium-toruloides-lifespan
#10
JOURNAL ARTICLE
Chuks Kenneth Odoh, Luis Alberto Madrigal-Perez, Rasool Kamal
Rhodosporidium toruloides is a novel cell factory used to synthesis carotenoids, biosurfactants, and biofuel feedstocks. However, research on R. toruloides has generally centred on the manufacture of biochemicals, while analyses of its longevity have received scant attention. Understanding of R. toruloides longevity under different nutrient conditions could help to improve its biotechnological significance and metabolite production. Glucosylglycerol (GG) and proline are osmoprotectants that could revert the harmful effects of environmental stress...
March 28, 2024: Archives of Microbiology
https://read.qxmd.com/read/38546817/differences-between-cultured-astrocytes-from-neonatal-and-adult-wistar-rats-focus-on-in-vitro%C3%A2-aging-experimental-models
#11
JOURNAL ARTICLE
Fernanda Becker Weber, Camila Leite Santos, Amanda da Silva, Izaviany Schmitz, Ester Rezena, Carlos-Alberto Gonçalves, André Quincozes-Santos, Larissa Daniele Bobermin
Astrocytes play key roles regulating brain homeostasis and accumulating evidence has suggested that glia are the first cells that undergo functional changes with aging, which can lead to a decline in brain function. In this context, in vitro models are relevant tools for studying aged astrocytes and, here, we investigated functional and molecular changes in cultured astrocytes obtained from neonatal or adult animals submitted to an in vitro model of aging by an additional period of cultivation of cells after confluence...
March 28, 2024: In Vitro Cellular & Developmental Biology. Animal
https://read.qxmd.com/read/38546802/trends-in-burdens-of-disease-by-transmission-source-usa-2005-2020-and-hazard-identification-for-foods-focus-on-milkborne-disease
#12
JOURNAL ARTICLE
Michele M Stephenson, Margaret E Coleman, Nicholas A Azzolina
BACKGROUND: Robust solutions to global, national, and regional burdens of communicable and non-communicable diseases, particularly related to diet, demand interdisciplinary or transdisciplinary collaborations to effectively inform risk analysis and policy decisions. OBJECTIVE: U.S. outbreak data for 2005-2020 from all transmission sources were analyzed for trends in the burden of infectious disease and foodborne outbreaks. METHODS: Outbreak data from 58 Microsoft Access® data tables were structured using systematic queries and pivot tables for analysis by transmission source, pathogen, and date...
March 28, 2024: Journal of Epidemiology and Global Health
https://read.qxmd.com/read/38546768/determinants-of-cancer-screenings-participation-in-queensland-a-scoping-review
#13
JOURNAL ARTICLE
Paraniala Silas C Lui, Kamal Singh, Tam Nguyen, Brian Kurth, Thuc Phan, Ashleigh Nelson, Renata Danisevska, Tony De Ambrosis
Introduction Cancer screening programmes for cervical, breast, and colorectal cancer have successfully reduced mortality rates among target groups. However, a large proportion of women and men are unscreened. Aim This review aims to provide an overview of the literature regarding the determinants of cancer screening participation among target groups in Queensland. Methods Electronic databases were searched for studies on determinants of cancer screening participation in Queensland. Retrieved studies were screened, and eligible articles were selected for data extraction...
March 2024: Journal of Primary Health Care
https://read.qxmd.com/read/38546750/evaluation-of-the-treatment-effects-of-conditioned-medium-from-human-orbital-adipose-derived-stem-cells-in-a-corneal-alkali-burn-rabbit-model
#14
JOURNAL ARTICLE
Yu Cheng, Guangpeng Liu
Purpose: This study aimed to evaluate the effects of a new treatment-conditioned medium from human orbital adipose-derived stem cells (OASC-CM)-on corneal recovery after alkali burns in a rabbit model. Methods: The corneal alkali burn rabbit model was established and treated with OASC-CM, conditioned medium from human abdominal subcutaneous adipose-derived stem cells (ABASC-CM), and fresh control culture medium (con-CM) three times a day for 7 days, respectively. Subsequently, the treatment effects were evaluated and compared through clinical, histological, immunohistochemical, and cytokine evaluations...
March 28, 2024: Journal of Ocular Pharmacology and Therapeutics
https://read.qxmd.com/read/38546737/black-young-adult-superwomen-in-the-face-of-gendered-racial-microaggressions-contextualizing-challenges-with-acceptance-and-avoidance-and-emotional-eating
#15
JOURNAL ARTICLE
Vanessa V Volpe, Abbey N Collins, Julia M Ross, Katrina R Ellis, Jioni A Lewis, Brianna A Ladd, Stephanie L Fitzpatrick
BACKGROUND: Black young adult women (ages 18-35) are at disproportionate risk for obesity and emotional eating. Emotional eating interventions target psychological flexibility, such as reducing experiential avoidance and increasing acceptance of food-related thoughts. Yet Black women face gendered racism, and some endorse roles that reduce psychological flexibility, such as the superwoman schema role. Culturally centered stress and coping has often been overlooked, leading to an incomplete understanding of processes that engender emotional eating and the implications for appropriate and effective interventions for Black young adult women...
March 28, 2024: Annals of Behavioral Medicine: a Publication of the Society of Behavioral Medicine
https://read.qxmd.com/read/38546630/indirect-associations-between-immigration-related-stressors-and-latine-adolescents-depressive-symptoms-the-moderating-roles-of-familism-nativity-and-gender
#16
JOURNAL ARTICLE
Alexander M Wasserman, Lisa J Crockett, Meredith L Cartwright, Chelsie D Temmen
OBJECTIVES: This study examined the indirect relationship between immigration-related stressors and depressive symptoms via family conflict and whether familism values moderated this relationship in a sample of U.S. Latine youth. We also explored nativity and gender differences in the predictive model. METHOD: Participants were 306 Midwestern Latine youth (Mage = 15.50, 46.2% girls, 79.9% Mexican origin) and their primary caregivers who completed measures of study constructs...
April 2024: Cultural Diversity & Ethnic Minority Psychology
https://read.qxmd.com/read/38546588/recasting-racial-coping-stress-in-school-self-efficacy-as-buffer-for-adolescent-agency
#17
JOURNAL ARTICLE
Howard C Stevenson, Emily A Aisenbrey, Sasha C Mejia-Bradford, Michael J Rovine
OBJECTIVE: The consequences of racism and racial stress on the academic and social well-being of adolescents are profound and well-documented. However, our understanding of how adolescents navigate racial stress and develop the agency to address discriminatory encounters, particularly in settings where educators struggle to intervene with microaggressions, remains limited. Research into the development of racial coping self-efficacy (RCSE) and coping skills has shown promise in enhancing the overall well-being of youth...
March 28, 2024: Cultural Diversity & Ethnic Minority Psychology
https://read.qxmd.com/read/38546584/nlrp3-inflammasome-priming-in-the-retina-of-diabetic-mice-requires-redd1-dependent-activation-of-gsk3%C3%AE
#18
JOURNAL ARTICLE
Christopher M McCurry, Siddharth Sunilkumar, Sandeep M Subrahmanian, Esma I Yerlikaya, Allyson L Toro, Ashley M VanCleave, Shaunaci A Stevens, Alistair J Barber, Jeffery M Sundstrom, Michael D Dennis
PURPOSE: Inflammasome activation has been implicated in the development of retinal complications caused by diabetes. This study was designed to identify signaling events that promote retinal NOD-, LRR-, and pyrin domain-containing protein 3 (NLRP3) inflammasome activation in response to diabetes. METHODS: Diabetes was induced in mice by streptozotocin administration. Retinas were examined after 16 weeks of diabetes. Human MIO-M1 Müller cells were exposed to hyperglycemic culture conditions...
March 5, 2024: Investigative Ophthalmology & Visual Science
https://read.qxmd.com/read/38546583/lack-of-elevated-expression-of-tgf%C3%AE-3-contributes-to-the-delay-of-epithelial-wound-healing-in-diabetic-corneas
#19
JOURNAL ARTICLE
Nan Gao, Fu-Shin Yu
PURPOSE: To investigate the mechanisms underlying the differential roles of TGFβ1 and TGFβ3 in accelerating corneal epithelial wound healing (CEWH) in diabetic (DM) corneas, with normoglycemia (NL) corneas as the control. METHODS: Two types of diabetic mice, human corneal organ cultures, mouse corneal epithelial progenitor cell lines, and bone marrow-derived macrophages (BMDMs) were employed to assess the effects of TGFβ1 and TGFβ3 on CEWH, utilizing quantitative PCR, western blotting, ELISA, and whole-mount confocal microscopy...
March 5, 2024: Investigative Ophthalmology & Visual Science
https://read.qxmd.com/read/38546564/cultural-stress-personal-identity-development-and-mental-health-among-u-s-hispanic-college-students
#20
JOURNAL ARTICLE
Seth J Schwartz, Cory L Cobb, Alan Meca, Tara Bautista, Sumeyra Sahbaz, Aigerim Alpysbekova, Lawrence G Watkins, Lea Nehme, Byron L Zamboanga, Pablo Montero-Zamora, Maria Duque, Duyen H Vo, Yara Acaf, José Szapocznik
The present study examines the extent to which culturally stressful experiences may predict impaired well-being, increased internalizing symptoms (depression and anxiety), and increased externalizing problems (social aggression, physical aggression, and rule breaking) among a sample of Hispanic college students in Miami across a 12-day period. The predictive effects of cultural stressors on these outcomes were examined both (a) directly and (b) indirectly through daily fluctuations in students' personal identity synthesis and confusion...
March 28, 2024: American Journal of Orthopsychiatry
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