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https://www.readbyqxmd.com/read/27904842/the-challenges-of-cardiothoracic-surgery-practice-in-nigeria-a-12-years-institutional-experience
#1
Bode Falase, Michael Sanusi, Adeola Animasahun, Ogadinma Mgbajah, Adetinuwe Majekodunmi, Onyekwelu Nzewi, Jonathan Nwiloh, David Oke
BACKGROUND: Although the specialty of cardiothoracic surgery has been practiced in Nigeria for many years, open heart surgery (OHS) has only in the last decade become relatively more frequent, mainly through visiting foreign cardiac surgical teams. At this early phase of development it is faced with multiple challenges, especially financing and local skilled manpower for which solutions have to be identified in order to ensure sustainability and future growth. This study is aimed at highlighting these obstacles to growth of cardiothoracic surgery based on our own institutional experience at Lagos State University Teaching Hospital (LASUTH) and the current status of OHS activity in other cardiothoracic centers in Nigeria...
October 2016: Cardiovascular Diagnosis and Therapy
https://www.readbyqxmd.com/read/27811127/collet-sicard-syndrome-a-rare-but-important-presentation-of-internal-jugular-vein-thrombosis
#2
Shermyn Neo, Kim En Lee
We describe a rare neurological presentation of internal jugular vein thrombosis induced by central venous catheter placement in a patient with cancer. A 71-year-old man gave a 3-week history of dysphagia and dysarthria with left-sided neck pain and headache. He was receiving chemotherapy for appendiceal adenocarcinoma. On examination, he had left 9th-12th cranial neuropathies, manifesting as voice hoarseness, decreased palatal movement, absent gag reflex, weakness of scapular elevation and left-sided tongue wasting...
November 3, 2016: Practical Neurology
https://www.readbyqxmd.com/read/27785660/long-term-impact-of-postoperative-complications-on-cancer-recurrence-following-lung-cancer-surgery
#3
Takashi Nojiri, Toshimitsu Hamasaki, Masayoshi Inoue, Yasushi Shintani, Yukiyasu Takeuchi, Hajime Maeda, Meinoshin Okumura
BACKGROUND: Postoperative complications are associated with poor cancer-specific survival in various types of cancer surgery. Recent studies suggest that systemic inflammation induced by surgical trauma can accelerate the adhesion of circulating tumor cells to the vascular endothelium of distant organs, resulting in early cancer recurrence. We investigated the impact of postoperative cardiopulmonary complications on cancer recurrence following lung cancer surgery. METHODS: From a prospective database of 675 consecutive patients who underwent curative surgery for lung cancer between 2007 and 2012, the incidence of postoperative cardiopulmonary complications, white blood cell counts, and C-reactive protein levels were evaluated in the acute phase after surgery...
October 26, 2016: Annals of Surgical Oncology
https://www.readbyqxmd.com/read/27761084/role-of-adipose-derived-stem-cells-in-fat-grafting-and-reconstructive-surgery
#4
Shaun S Tan, Zhi Yang Ng, Weiqing Zhan, Warren Rozen
Autologous fat grafting is commonly utilised to reconstruct soft tissue defects caused by ageing, trauma, chronic wounds and cancer resection. The benefits of fat grafting are minimal donor site morbidity and ease of availability through liposuction or lipectomy. Nonetheless, survival and longevity of fat grafts remain poor post-engraftment. Various methods to enhance fat graft survival are currently under investigation and its stem cell constituents are of particular interest. Cell-assisted lipotransfer refers to the addition of adipose-derived stem cell (ASC) rich component of stromal vascular fraction to lipoaspirate, the results of which have proven promising...
July 2016: Journal of Cutaneous and Aesthetic Surgery
https://www.readbyqxmd.com/read/27722710/bioprinted-thrombosis-on-a-chip
#5
Yu Shrike Zhang, Farideh Davoudi, Philipp Walch, Amir Manbachi, Xuan Luo, Valeria Dell'Erba, Amir K Miri, Hassan Albadawi, Andrea Arneri, Xiaoyun Li, Xiaoying Wang, Mehmet Remzi Dokmeci, Ali Khademhosseini, Rahmi Oklu
Pathologic thrombosis kills more people than cancer and trauma combined; it is associated with significant disability and morbidity, and represents a major healthcare burden. Despite advancements in medical therapies and imaging, there is often incomplete resolution of the thrombus. The residual thrombus can undergo fibrotic changes over time through infiltration of fibroblasts from the surrounding tissues and eventually transform into a permanent clot often associated with post-thrombotic syndrome. In order to understand the importance of cellular interactions and the impact of potential therapeutics to treat thrombosis, an in vitro platform using human cells and blood components would be beneficial...
October 18, 2016: Lab on a Chip
https://www.readbyqxmd.com/read/27335300/-development-application-details-and-prospects-of-uni-vats-on-lung-cancer-radical-operation-under-the-concept-of-precise-medical-treatment
#6
Yu Deng, Zhipeng Hao, Xiangning Fu
Uniportal video-assisted thoracic surgery (Uni-VATS) has become one of the most exciting new developments in minimally invasive thoracic surgery in recent 5 years. With the development of better thoracoscopic cameras and the availability of endoscopic linear mechanical staplers, experts in the technique are able to use uniportal VATS to encompass the most complex procedures such as bronchial sleeve/vascular reconstructions or carinal resections. A large number of multi-center reports have confirmed that Uni-VATS lobectomy is safe and feasible; dissected node group number and total number of mediastinal lymph nodes were not less than that of traditional muli VATS; Uni-VATS gained positive results in pain, trauma and recovery time...
June 20, 2016: Zhongguo Fei Ai za Zhi, Chinese Journal of Lung Cancer
https://www.readbyqxmd.com/read/27262308/an-extremely-rare-case-report-of-surgery-of-lung-cancer-with-the-absence-of-azygos-vein
#7
Maiko Atari, Yuki Nakajima, Mitsuro Fukuhara, Yoshihito Iijima, Hiroyasu Kinoshita, Yoshihiro Minamiya, Hidetaka Uramoto
In thoracic surgery, we occasionally encounter vessel anomalies. We herein report an extremely rare surgical case with the absence of the azygos vein. Mediastinal vascular abnormalities are said to be rare. The etiology of vascular abnormalities of the whole body, including the chest is known gene mutations, hormone abnormalities, infection, and trauma. But, many causes have been unknown. In thoracic surgery field, there is some reports and literature about pulmonary arteriovenous malformation, pulmonary sequestration, and partial anomalous pulmonary venous return...
June 4, 2016: Surgical and Radiologic Anatomy: SRA
https://www.readbyqxmd.com/read/27222696/implantable-port-devices-complications-and-outcome-in-pediatric-cancer-a-retrospective-study
#8
H Esfahani, M Ghorbanpor, A Tanasan
BACKGROUND: Peripheral blood vessels, due to availability are used for many years in cancer patients, however in patients with potentially harmful drugs to skin (vesicant drugs) or difficult accessibility to vessels, the use of implantable port (totally implantable venous access port-TIVAP) devices with central vascular access are important. MATERIALS AND METHODS: In this retrospective study, 85 pediatric cancer patients younger than 16 years, with TIVAP implantation, were followed for their complications and outcome...
2016: Iranian Journal of Pediatric Hematology and Oncology
https://www.readbyqxmd.com/read/27065215/using-noncontact-infrared-thermography-for-long-term-monitoring-of-foot-temperatures-in-a-patient-with-diabetes-mellitus
#9
Erik Staffa, Vladan Bernard, Luboš Kubíček, Robert Vlachovský, Daniel Vlk, Vojtěch Mornstein, Robert Staffa
Foot complications in persons with diabetes mellitus (DM) are associated with substantial costs and loss of quality of life. Increasing evidence suggests changes in skin temperature, measured using an infrared thermographic system (IRT), may be a predictor of foot ulcer development in patients with DM. The purpose of this case study is to describe the long-term IRT findings and overall clinical outcomes of a patient with DM and peripheral vascular disease. Foot temperature measurements using IRT were obtained slightly more than 1 year before and immediately following endovascular treatment of a 76-year-old man, a nonsmoker with type 2 DM, hypertension, and ischemic heart disease with cardiac arrhythmia...
April 2016: Ostomy/wound Management
https://www.readbyqxmd.com/read/27062926/a-reservoir-of-mature-cavity-macrophages-that-can-rapidly-invade-visceral-organs-to-affect-tissue-repair
#10
Jing Wang, Paul Kubes
A key feature of inflammation is the timely recruitment of leukocytes, including monocytes, from blood into tissues, the latter maturing into macrophages over a period of 2-3 days. Using multi-channel spinning disk microscopy, we identified a rapid pathway of macrophage recruitment into an injured organ via a non-vascular route requiring no maturation from monocytes. In response to a sterile injury in liver, a reservoir of fully mature F4/80(hi)GATA6(+) peritoneal cavity macrophages rapidly invaded into afflicted tissue via direct recruitment across the mesothelium...
April 21, 2016: Cell
https://www.readbyqxmd.com/read/26999969/-nontraumatic-causes-of-bilateral-avascular-necrosis-of-the-femoral-head-link-between-hepatitis-c-and-pegylated-interferon
#11
REVIEW
J G Gómez-Mont Landerreche, F Gil-Orbezo, H Morales-Dominguez, M Navarrete-Álvarez, C Trueba-Davalillo, P Capuano-Tripp
BACKGROUND: Avascular necrosis of the femoral head is a frequent condition in patients with a history of trauma. The major pathologic causes include vascular diseases, malignancies, hypercoagulability states, long-term steroid treatment, and some patients have a history of hepatitis C infection treated with pegylated interferon and ribavirin. Upon studying the behavior of the hepatitis C virus, Seef, Foster and Poynard found a hypercoagulability state that causes interruption of retinacular blood flow to the femoral head, without an increased incidence of osteonecrosis in this patient group...
May 2015: Acta Ortopédica Mexicana
https://www.readbyqxmd.com/read/26895582/evolving-concepts-of-keystone-perforator-island-flaps-kpif-principles-of-perforator-anatomy-design-modifications-and-extended-clinical-applications
#12
Anita T Mohan, Charalambos K Rammos, Arya A Akhavan, Jorys Martinez, Peter S Wu, Steven L Moran, Franklin H Sim, Felix Behan, Samir Mardini, Michel Saint-Cyr
BACKGROUND: Keystone flaps have demonstrated growing clinical applications in reconstructive surgery in the past decade. This article highlights flap modifications and their versatility for clinical applications and management of complex defects. METHODS: A retrospective chart review was conducted of consecutive patients undergoing keystone flap reconstruction at the authors' institution from January of 2012 to December of 2014. Patient demographics, indications, and operative and postoperative details were abstracted...
June 2016: Plastic and Reconstructive Surgery
https://www.readbyqxmd.com/read/26827083/surgical-management-of-chronic-wounds
#13
Benjamin R Johnston, Austin Y Ha, Daniel Kwan
In this article, we outline the important role the surgeon plays in the management of chronic wounds. Debridement and washout are required for grossly infected wounds and necrotizing soft tissue infections. Cutaneous cancers such as squamous cell carcinomas may contribute to chronic wounds and vice versa; if diagnosed, these should be treated with wide local excision. Arterial, venous, and even lymphatic flows can be restored in select cases to enhance delivery of nutrients and removal of metabolic waste and promote wound healing...
February 2016: Rhode Island Medical Journal
https://www.readbyqxmd.com/read/26818116/sunitinib-treatment-reduces-tumor-growth-and-limits-changes-in-microvascular-properties-after-minor-surgical-intervention-in-an-in-vivo-model-of-secondary-breast-cancer-growth-in-bone
#14
Malte Schroeder, Lennart Viezens, Jasmin Wellbrock, Walter Fiedler, Wolfgang Rüther, Petra Algenstaedt, Nils Hansen-Algenstaedt, Christian Schaefer
BACKGROUND AND OBJECTIVES: Surgical interventions can alter the balance between pro- and anti-angiogenic growth factors and thereby modulate tumor growth. Since the microcirculatory properties of tumors underlie organ-specific differences, the microhemodynamic characteristics of bone metastasis have not yet been fully described. Angiogenesis inhibitors are increasingly being used to treat advanced stages of cancer. We hypothesized that the anti-angiogenic drug sunitinib abrogates alterations in microvascular properties following a minor surgical intervention in an in vivo model of secondary breast cancer growth in the bone...
April 2016: Journal of Surgical Oncology
https://www.readbyqxmd.com/read/26787738/understanding-platelet-generation-from-megakaryocytes-implications-for-in-vitro-derived-platelets
#15
REVIEW
Xiuli Sim, Mortimer Poncz, Paul Gadue, Deborah L French
Platelets are anucleate cytoplasmic discs derived from megakaryocytes that circulate in the blood and have major roles in hemostasis, thrombosis, inflammation, and vascular biology. Platelet transfusions are required to prevent the potentially life-threatening complications of severe thrombocytopenia seen in a variety of medical settings including cancer therapy, trauma, and sepsis. Platelets used in the clinic are currently donor-derived which is associated with concerns over sufficient availability, quality, and complications due to immunologic and/or infectious issues...
March 10, 2016: Blood
https://www.readbyqxmd.com/read/26350744/-oxidative-stress-in-platelets-at-an-oncopathology
#16
E G Gorozhanskaya, S P Sviridova, V N Baykova, G N Zubrikhina, M M Dobrovolskaya, A V Sitov
To determine the biochemical disorders in the blood coagulation mechanism associated with oxidative stress parameters of the antioxidant status were examined in platelets of 57 colorectal cancer patients, (including 21 patients before and after surgery), and 40 healthy individuals. We determined the total content of nitric oxide (NOx), levels of superoxide dismutase (Cu/ZnSOD), glutathione and malondialdehyde (MDA). Before treatment, we observed the changes in the antioxidant defense system of platelets, which did not depend on the prevalence of malignancy: elevated levels of SOD by 16% (p<0...
July 2015: Biomedit︠s︡inskai︠a︡ Khimii︠a︡
https://www.readbyqxmd.com/read/26318757/dynamic-muscle-o2-saturation-response-is-impaired-during-major-non-cardiac-surgery-despite-goal-directed-haemodynamic-therapy
#17
A Feldheiser, O Hunsicker, L Kaufner, J Köhler, H Sieglitz, R Casans Francés, K-D Wernecke, J Sehouli, C Spies
BACKGROUND: Near-infrared spectroscopy combined with a vascular occlusion test (VOT) could indicate an impairment of microvascular reactivity (MVR) in septic patients by detecting changes in dynamic variables of muscle O2 saturation (StO2). However, in the perioperative context the consequences of surgical trauma on dynamic variables of muscle StO2 as indicators of MVR are still unknown. METHODS: This study is a sub-analysis of a randomised controlled trial in patients with metastatic primary ovarian cancer undergoing debulking surgery, during which a goal-directed haemodynamic algorithm was applied using oesophageal Doppler...
March 2016: Revista Española de Anestesiología y Reanimación
https://www.readbyqxmd.com/read/26293085/transition-of-decade-in-short-bowel-syndrome-in-china-yesterday-today-and-tomorrow
#18
W Kong, J Wang, X Ni, Y Li, Q Mao, D Yao, S Fan, Y Chen, Z Cai, J Li
BACKGROUND: Short bowel syndrome (SBS) patients need long-term parenteral nutrition or intestine transplantation. With the development of medicine, society, and economy over the past decade, characteristics of these patients might have undergone some changes. To study the issue, we conducted this retrospective study. METHODS: A retrospective study was conducted from January 1, 2004, to January 1, 2014, in an intestinal rehabilitation and transplant center. A total of 335 SBS patients were hospitalized at our center...
July 2015: Transplantation Proceedings
https://www.readbyqxmd.com/read/26149054/extracellular-dna-and-histones-double-edged-swords-in-immunothrombosis
#19
REVIEW
T J Gould, Z Lysov, P C Liaw
The existence of extracellular DNA in human plasma, also known as cell-free DNA (cfDNA), was first described in the 1940s. In recent years, there has been a resurgence of interest in the functional significance of cfDNA, particularly in the context of neutrophil extracellular traps (NETs). cfDNA and histones are key components of NETs that aid in the host response to infection and inflammation. However, cfDNA and histones may also exert harmful effects by triggering coagulation, inflammation, and cell death and by impairing fibrinolysis...
June 2015: Journal of Thrombosis and Haemostasis: JTH
https://www.readbyqxmd.com/read/25891841/is-lipid-lowering-therapy-an-independent-risk-factor-for-venous-thromboembolism-a-population-based-case-control-study
#20
Aneel A Ashrani, Michel K Barsoum, Daniel J Crusan, Tanya M Petterson, Kent R Bailey, John A Heit
INTRODUCTION: The independent effect of lipid lowering therapy (LLT) on venous thromboembolism (VTE) risk is uncertain. OBJECTIVE: To test statin and non-statin LLT as potential VTE risk factors. METHODS: Using Rochester Epidemiology Project resources, we identified all Olmsted County, MN residents with objectively diagnosed incident VTE (cases) over the 13-year period, 1988-2000 (n=1340), and one to two matched controls (n=1538). We reviewed their complete medical records for baseline characteristics previously identified as independent VTE risk factors, and for statin and non-statin LLT...
June 2015: Thrombosis Research
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