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https://www.readbyqxmd.com/read/29146409/safety-and-effectiveness-of-long-term-treatment-with-lurasidone-in-older-adults-with-bipolar-depression-post-hoc-analysis-of-a-6-month-open-label-study
#1
Brent P Forester, Martha Sajatovic, Joyce Tsai, Andrei Pikalov, Josephine Cucchiaro, Antony Loebel
OBJECTIVE: To evaluate the safety and effectiveness of 6 months of treatment with lurasidone in older adults with a diagnosis of bipolar I depression. DESIGN: Post-hoc analysis of a multicenter, 6-month, open-label extension study. SETTING: Outpatient. PARTICIPANTS: Patients aged 55 to 75 years with a DSM-IV-TR diagnosis of bipolar I depression who had completed 6 weeks of double-blind, placebo-controlled treatment with either lurasidone monotherapy (1 study) or adjunctive therapy with lithium or valproate (2 studies)...
October 10, 2017: American Journal of Geriatric Psychiatry
https://www.readbyqxmd.com/read/29127643/characterization-of-a-novel-asparaginase-from-soil-metagenomic-libraries-generated-from-forest-soil
#2
Jaya Kumar Arjun, Balakrishna Pillai Aneesh, Thulasi Kavitha, Kumarapillai Harikrishnan
OBJECTIVES: To screen soil metagenomic libraries for novel enzymes with enhanced activities. RESULTS: To screen soil metagenomic libraries for novel enzymes with enhanced activities. A novel L-asparaginase was identified from forest soil metagenome and its characteristics were studied. The purified protein had a specific activity of 696 IU mg(-1) and optimum activity at pH 7 and 35 °C. Enhanced enzyme activities were observed in the presence of Mg(2+), Ca(2+) and K(+)...
November 10, 2017: Biotechnology Letters
https://www.readbyqxmd.com/read/29114027/an-alphavirus-e2-membrane-proximal-domain-promotes-envelope-protein-lateral-interactions-and-virus-budding
#3
Emily A Byrd, Margaret Kielian
Alphaviruses are members of a group of small enveloped RNA viruses that includes important human pathogens such as Chikungunya virus and the equine encephalitis viruses. The virus membrane is covered by a lattice composed of 80 spikes, each a trimer of heterodimers of the E2 and E1 transmembrane proteins. During virus endocytic entry, the E1 glycoprotein mediates the low-pH-dependent fusion of the virus membrane with the endosome membrane, thus initiating virus infection. While much is known about E1 structural rearrangements during membrane fusion, it is unclear how the E1/E2 dimer dissociates, a step required for the fusion reaction...
November 7, 2017: MBio
https://www.readbyqxmd.com/read/29113376/efficacy-of-glucocorticoids-vitamin-a-and-caffeine-therapies-for-neonatal-mortality-in-preterm-infants-a-network-meta-analysis
#4
Ying Li, Jie Gao, Qiwei Wang, Xiaojian Ma
Introduction: The paper aimed to evaluate the efficacy of different therapies in improving survival among preterm infants. Materials and Methods: PubMed and Embase were searched from inception to 2017. We assessed studies for eligibility and extracted data. A Bayesian random-effects model was used to evaluate different therapies combined direct comparisons with indirect evidence. Consistency analysis was achieved using node-splitting plots. Surface under the cumulative ranking curve (SUCRA) was calculated to rank different therapies...
October 6, 2017: Oncotarget
https://www.readbyqxmd.com/read/29102599/differential-effects-of-lipid-biosynthesis-inhibitors-on-zika-and-semliki-forest-viruses
#5
Jamie Royle, Claire L Donald, Andres Merits, Alain Kohl, Margus Varjak
The recent outbreak of infection with Zika virus (ZIKV; Flaviviridae) has attracted attention to this previously neglected mosquito-borne pathogen and the need for efficient therapies. Since flavivirus replication is generally known to be dependent on fatty acid biosynthesis, two inhibitors of this pathway, 5-(tetradecyloxyl)-2-furoic acid (TOFA) and cerulenin, were tested for their potentiality to inhibit virus replication. At concentrations previously shown to inhibit the replication of other flaviviruses, neither drug had a significant antiviral affect against ZIKV, but reduced the replication of the non-related mosquito-borne Semliki Forest virus (Togaviridae)...
October 19, 2017: Veterinary Journal
https://www.readbyqxmd.com/read/29080881/-computational-prediction-of-human-immunodeficiency-resistance-to-reverse-transcriptase-inhibitors
#6
O A Tarasova, D A Filimonov, V V Poroikov
Human immunodeficiency virus (HIV) causes acquired immunodeficiency syndrome (AIDS) and leads to over one million of deaths annually. Highly active antiretroviral treatment (HAART) is a gold standard in the HIV/AIDS therapy. Nucleoside and non-nucleoside inhibitors of HIV reverse transcriptase (RT) are important component of HAART, but their effect depends on the HIV susceptibility/resistance. HIV resistance mainly occurs due to mutations leading to conformational changes in the three-dimensional structure of HIV RT...
October 2017: Biomedit︠s︡inskai︠a︡ Khimii︠a︡
https://www.readbyqxmd.com/read/29060633/segmentation-of-hyper-acute-cerebral-infarct-based-on-random-forest-and-sparse-coding-from-diffusion-weighted-imaging
#7
Xiaodong Zhang, Ahmed Elazab, Qingmao Hu
Irreversible infarcts are critical for the assessment of potential risk and benefit pertaining to thrombolysis in hyper-acute ischemic stroke. It is a challenging work to segment infarct at hyper-acute stage due to the substantial variability. A general abnormal tissue segmentation method is proposed and applied to segment hyper-acute ischemic infarct in this paper. Multiple features are designed to train a random forest classifier for voxel classification. Sparse coding based bag-of-features is adopted to train a region classifier for infarct region recognition...
July 2017: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/29054255/predicting-cd4-count-changes-among-patients-on-antiretroviral-treatment-application-of-data-mining-techniques
#8
Mihiretu Kebede, Desalegn Tigabu Zegeye, Berihun Megabiaw Zeleke
BACKGROUND AND OBJECTIVES: To monitor the progress of therapy and disease progression, periodic CD4 counts are required throughout the course of HIV/AIDS care and support. The demand for CD4 count measurement is increasing as ART programs expand over the last decade. This study aimed to predict CD4 count changes and to identify the predictors of CD4 count changes among patients on ART. METHODS: A cross-sectional study was conducted at the University of Gondar Hospital from 3,104 adult patients on ART with CD4 counts measured at least twice (baseline and most recent)...
December 2017: Computer Methods and Programs in Biomedicine
https://www.readbyqxmd.com/read/29050243/cancer-specific-evaluation-system-canes-a-high-accuracy-platform-for-preclinical-single-multi-biomarker-discovery
#9
Min-Seok Kwon, Seungyoon Nam, Sungyoung Lee, Young Zoo Ahn, Hae Ryung Chang, Yon Hui Kim, Taesung Park
The recent creation of enormous, cancer-related "Big Data" public depositories represents a powerful means for understanding tumorigenesis. However, a consistently accurate system for clinically evaluating single/multi-biomarkers remains lacking, and it has been asserted that oft-failed clinical advancement of biomarkers occurs within the very early stages of biomarker assessment. To address these challenges, we developed a clinically testable, web-based tool, CANcer-specific single/multi-biomarker Evaluation System (CANES), to evaluate biomarker effectiveness, across 2,134 whole transcriptome datasets, from 94,147 biological samples (from 18 tumor types)...
September 19, 2017: Oncotarget
https://www.readbyqxmd.com/read/29034935/hedgehog-mesenchyme-gene-signature-identifies-bi-modal-prognosis-in-luminal-and-basal-breast-cancer-sub-types
#10
Wandaliz Torres-García, Maribella Domenech
Hedgehog signaling (Hh) has been shown to be hyper-activated in several cancers. However, active Hh signaling can promote or inhibit tumor growth; thus identification of markers beyond main canonical Hh target genes is needed to improve patient selection and clinical outcome in response to Hh inhibitors. Cancer-associated fibroblasts (CAFs) have been linked with tumor progression and beneficial response to Hh inhibitors. Thus, we hypothesized that genes associated with Hh-activated CAFs can be used for stratification of tumors that will benefit from Hh inhibitors...
October 16, 2017: Molecular BioSystems
https://www.readbyqxmd.com/read/29026497/methadone-replacement-therapy-and-sexual-disorders-among-opium-dependent-iranian-men-a-meta-analysis-study
#11
Masoudeh Babakhanian, Ali Akbar Haghdoost, Mahdi Afshari, Fatemeh Taghizadeh, Mahmood Moosazadeh
BACKGROUND: Evaluation of sexual disorders among persons receiving methadone replacement therapy is of great importance, because these problems may lead to non-compliance and relapse. This study aimed to estimate the effect of methadone maintenance therapy (MMT) on sexual function among addicted Iranian men using met-analysis. METHODS: Investigating the available data banks, relevant studies were identified. After exclusion of duplicates, irrelevant papers and low quality articles, eligible papers were entered into the meta-analysis...
January 2017: Addiction & Health
https://www.readbyqxmd.com/read/28988525/the-role-of-biofilm-forming-on-mortality-in-patients-with-candidemia-a-study-derived-from-real-world-data
#12
Carlo Tascini, Emanuela Sozio, Laura Corte, Francesco Sbrana, Claudio Scarparo, Andrea Ripoli, Giacomo Bertolino, Maria Merelli, Enrico Tagliaferri, Antonio Corcione, Matteo Bassetti, Gianluigi Cardinali, Francesco Menichetti
BACKGROUND: Evaluation of the role on patient mortality exerted by biofilm forming (BF) Candida strains, by using predictive clinical data. METHODS: Eighty-nine strains isolated from Candida bloodstream infection, occurring in two Italian University Hospitals, were employed in this study. A random forest (RF) model was built with a procedure of iterative selection of the risk factors potentially able to predict the probability of death. The similarity between patient conditions and Bayesian clustering was calculated in order to evaluate the role of predictors in the stratification of the death risk...
October 9, 2017: Infectious Diseases
https://www.readbyqxmd.com/read/28973761/chemotherapeutical-effects-of-the-herbal-medicine-uncaria-tomentosa-willd-dc
#13
I V Almeida, L C Soares, F T Lucio, L B Cantagalli, A F Reusing, V E P Vicentini
The use of medicinal plants dates back to the beginning of humanity, and today their application as complementary therapy has been widely disseminated as an alternative to conventional therapy. The medicinal plant named Uncaria tomentosa (Willd.) DC. (known as cat's claw) is a common woody vine of the Amazon forest that has traditionally been used in the treatment of arthritis because of its anti-inflammatory properties. This study aimed to evaluate the cytotoxic, mutagenic, and antimutagenic potentials of this medicinal plant...
September 27, 2017: Genetics and Molecular Research: GMR
https://www.readbyqxmd.com/read/28961949/improved-prediction-of-breast-cancer-outcome-by-identifying-heterogeneous-biomarkers
#14
Jonghwan Choi, Sanghyun Park, Youngmi Yoon, Jaegyoon Ahn
Motivation: Identification of genes that can be used to predict prognosis in patients with cancer is important in that it can lead to improved therapy, and can also promote our understanding of tumor progression on the molecular level. One of the common but fundamental problems that render identification of prognostic genes and prediction of cancer outcomes difficult is the heterogeneity of patient samples. Results: To reduce the effect of sample heterogeneity, we clustered data samples using K-means algorithm and applied modified PageRank to functional interaction (FI) networks weighted using gene expression values of samples in each cluster...
November 15, 2017: Bioinformatics
https://www.readbyqxmd.com/read/28959161/magnetic-resonance-imaging-evaluation-in-neoadjuvant-therapy-of-locally-advanced-rectal-cancer-a-systematic-review
#15
Roberta Fusco, Mario Petrillo, Vincenza Granata, Salvatore Filice, Mario Sansone, Orlando Catalano, Antonella Petrillo
BACKGROUND: The aim of the study was to present an update concerning several imaging modalities in diagnosis, staging and pre-surgery treatment response assessment in locally advanced rectal cancer (LARC). Modalities include: traditional morphological magnetic resonance imaging (MRI), functional MRI such as dynamic contrast enhanced MRI (DCE-MRI) and diffusion weighted imaging (DWI). A systematic review about the diagnostic accuracy in neoadjuvant therapy response assessment of MRI, DCE-MRI, DWI and Positron Emission Tomography/Computed Tomography (PET/CT) has been also reported...
September 2017: Radiology and Oncology
https://www.readbyqxmd.com/read/28894899/clinical-impact-of-psma-based-18-f-dcfbc-pet-ct-imaging-in-patients-with-biochemically-recurrent-prostate-cancer-after-primary-local-therapy
#16
Esther Mena, Maria L Lindenberg, Joanna H Shih, Stephen Adler, Stephanie Harmon, Ethan Bergvall, Deborah Citrin, William Dahut, Anita T Ton, Yolanda McKinney, Juanita Weaver, Philip Eclarinal, Alicia Forest, George Afari, Sibaprasad Bhattacharyya, Ronnie C Mease, Maria J Merino, Peter Pinto, Bradford J Wood, Paula Jacobs, Martin G Pomper, Peter L Choyke, Baris Turkbey
PURPOSE: The purpose of our study was to assess (18)F-DCFBC PET/CT, a PSMA targeted PET agent, for lesion detection and clinical management of biochemical relapse in prostate cancer patients after primary treatment. METHODS: This is a prospective IRB-approved study of 68 patients with documented biochemical recurrence after primary local therapy consisting of radical prostatectomy (n = 50), post radiation therapy (n = 9) or both (n = 9), with negative conventional imaging...
September 11, 2017: European Journal of Nuclear Medicine and Molecular Imaging
https://www.readbyqxmd.com/read/28874808/rert-a-novel-regression-tree-approach-to-predict-extrauterine-disease-in-endometrial-carcinoma-patients
#17
Marika Vezzoli, Antonella Ravaggi, Laura Zanotti, Rebecca Angelica Miscioscia, Eliana Bignotti, Monica Ragnoli, Angela Gambino, Giuseppina Ruggeri, Stefano Calza, Enrico Sartori, Franco Odicino
Some aspects of endometrial cancer (EC) preoperative work-up are still controversial, and debatable are the roles played by lymphadenectomy and radical surgery. Proper preoperative EC staging can help design a tailored surgical treatment, and this study aims to propose a new algorithm able to predict extrauterine disease diffusion. 293 EC patients were consecutively enrolled, and age, BMI, children's number, menopausal status, contraception, hormone replacement therapy, hypertension, histological grading, clinical stage, and serum HE4 and CA125 values were preoperatively evaluated...
September 5, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28869493/vaccines-against-botulism
#18
REVIEW
Grace Sundeen, Joseph T Barbieri
Botulinum neurotoxins (BoNT) cause the flaccid paralysis of botulism by inhibiting the release of acetylcholine from motor neurons. There are seven serotypes of BoNT (A-G), with limited therapies, and no FDA approved vaccine for botulism. An investigational formalin-inactivated penta-serotype-BoNT/A-E toxoid vaccine was used to vaccinate people who are at high risk of contracting botulism. However, this formalin-inactivated penta-serotype-BoNT/A-E toxoid vaccine was losing potency and was discontinued. This article reviews the different vaccines being developed to replace the discontinued toxoid vaccine...
September 2, 2017: Toxins
https://www.readbyqxmd.com/read/28830985/characterization-of-in-vivo-resistance-to-osimertinib-and-jnj-61186372-an-egfr-met-bispecific-antibody-reveals-unique-and-consensus-mechanisms-of-resistance
#19
Kristina B Emdal, Antje Dittmann, Raven J Reddy, Rebecca S Lescarbeau, Sheri L Moores, Sylvie Laquerre, Forest M White
Approximately 10% of non-small cell lung cancer (NSCLC) patients in the United States and 40% of NSCLC patients in Asia have activating epidermal growth factor receptor (EGFR) mutations and are eligible to receive targeted anti-EGFR therapy. Despite an extension of life expectancy associated with this treatment, resistance to EGFR tyrosine kinase inhibitors and anti-EGFR antibodies is almost inevitable. To identify additional signaling routes that can be cotargeted to overcome resistance, we quantified tumor-specific molecular changes that govern resistant cancer cell growth and survival...
November 2017: Molecular Cancer Therapeutics
https://www.readbyqxmd.com/read/28828481/primeum-a-model-for-predicting-risk-of-metastasis-in-uveal-melanoma
#20
Jorge Vaquero-Garcia, Emilie Lalonde, Kathryn G Ewens, Jessica Ebrahimzadeh, Jennifer Richard-Yutz, Carol L Shields, Alejandro Barrera, Christopher J Green, Yoseph Barash, Arupa Ganguly
Purpose: To create an interactive web-based tool for the Prediction of Risk of Metastasis in Uveal Melanoma (PRiMeUM) that can provide a personalized risk estimate of developing metastases within 48 months of primary uveal melanoma (UM) treatment. The model utilizes routinely collected clinical and tumor characteristics on 1227 UM, with the option of including chromosome information when available. Methods: Using a cohort of 1227 UM cases, Cox proportional hazard modeling was used to assess significant predictors of metastasis including clinical and chromosomal characteristics...
August 1, 2017: Investigative Ophthalmology & Visual Science
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