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https://www.readbyqxmd.com/read/28894899/clinical-impact-of-psma-based-18-f-dcfbc-pet-ct-imaging-in-patients-with-biochemically-recurrent-prostate-cancer-after-primary-local-therapy
#1
Esther Mena, Maria L Lindenberg, Joanna H Shih, Stephen Adler, Stephanie Harmon, Ethan Bergvall, Deborah Citrin, William Dahut, Anita T Ton, Yolanda McKinney, Juanita Weaver, Philip Eclarinal, Alicia Forest, George Afari, Sibaprasad Bhattacharyya, Ronnie C Mease, Maria J Merino, Peter Pinto, Bradford J Wood, Paula Jacobs, Martin G Pomper, Peter L Choyke, Baris Turkbey
PURPOSE: The purpose of our study was to assess (18)F-DCFBC PET/CT, a PSMA targeted PET agent, for lesion detection and clinical management of biochemical relapse in prostate cancer patients after primary treatment. METHODS: This is a prospective IRB-approved study of 68 patients with documented biochemical recurrence after primary local therapy consisting of radical prostatectomy (n = 50), post radiation therapy (n = 9) or both (n = 9), with negative conventional imaging...
September 11, 2017: European Journal of Nuclear Medicine and Molecular Imaging
https://www.readbyqxmd.com/read/28874808/rert-a-novel-regression-tree-approach-to-predict-extrauterine-disease-in-endometrial-carcinoma-patients
#2
Marika Vezzoli, Antonella Ravaggi, Laura Zanotti, Rebecca Angelica Miscioscia, Eliana Bignotti, Monica Ragnoli, Angela Gambino, Giuseppina Ruggeri, Stefano Calza, Enrico Sartori, Franco Odicino
Some aspects of endometrial cancer (EC) preoperative work-up are still controversial, and debatable are the roles played by lymphadenectomy and radical surgery. Proper preoperative EC staging can help design a tailored surgical treatment, and this study aims to propose a new algorithm able to predict extrauterine disease diffusion. 293 EC patients were consecutively enrolled, and age, BMI, children's number, menopausal status, contraception, hormone replacement therapy, hypertension, histological grading, clinical stage, and serum HE4 and CA125 values were preoperatively evaluated...
September 5, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28869493/vaccines-against-botulism
#3
REVIEW
Grace Sundeen, Joseph T Barbieri
Botulinum neurotoxins (BoNT) cause the flaccid paralysis of botulism by inhibiting the release of acetylcholine from motor neurons. There are seven serotypes of BoNT (A-G), with limited therapies, and no FDA approved vaccine for botulism. An investigational formalin-inactivated penta-serotype-BoNT/A-E toxoid vaccine was used to vaccinate people who are at high risk of contracting botulism. However, this formalin-inactivated penta-serotype-BoNT/A-E toxoid vaccine was losing potency and was discontinued. This article reviews the different vaccines being developed to replace the discontinued toxoid vaccine...
September 2, 2017: Toxins
https://www.readbyqxmd.com/read/28830985/characterization-of-in-vivo-resistance-to-osimertinib-and-jnj-61186372-an-egfr-met-bi-specific-antibody-reveals-unique-and-consensus-mechanisms-of-resistance
#4
Kristina B Emdal, Antje Dittmann, Raven J Reddy, Rebecca S Lescarbeau, Sheri L Moores, Sylvie Laquerre, Forest M White
Approximately 10% of non-small cell lung cancer (NSCLC) patients in the U.S. and 40% of NSCLC patients in Asia have activating EGFR mutations and are eligible to receive targeted anti-EGFR therapy. Despite an extension of life expectancy associated with this treatment, resistance to EGFR tyrosine kinase inhibitors and anti-EGFR antibodies is almost inevitable. To identify additional signaling routes that can be co-targeted to overcome resistance, we quantified tumor-specific molecular changes that govern resistant cancer cell growth and survival...
August 22, 2017: Molecular Cancer Therapeutics
https://www.readbyqxmd.com/read/28828481/primeum-a-model-for-predicting-risk-of-metastasis-in-uveal-melanoma
#5
Jorge Vaquero-Garcia, Emilie Lalonde, Kathryn G Ewens, Jessica Ebrahimzadeh, Jennifer Richard-Yutz, Carol L Shields, Alejandro Barrera, Christopher J Green, Yoseph Barash, Arupa Ganguly
Purpose: To create an interactive web-based tool for the Prediction of Risk of Metastasis in Uveal Melanoma (PRiMeUM) that can provide a personalized risk estimate of developing metastases within 48 months of primary uveal melanoma (UM) treatment. The model utilizes routinely collected clinical and tumor characteristics on 1227 UM, with the option of including chromosome information when available. Methods: Using a cohort of 1227 UM cases, Cox proportional hazard modeling was used to assess significant predictors of metastasis including clinical and chromosomal characteristics...
August 1, 2017: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/28822397/outcomes-after-mastectomy-and-lumpectomy-in-octogenarians-and-nonagenarians-with-early-stage-breast-cancer
#6
Amelia Y Merrill, Doris R Brown, Heidi D Klepin, Edward A Levine, Marissa Howard-Mcnatt
Prospective studies have shown equal outcomes after mastectomy or breast conservation in patients with invasive breast cancer; however, many of these studies excluded elderly patients. We identified patients in their eighties and nineties with clinical stage 0 to II breast cancer undergoing mastectomy or lumpectomy with or without radiation from the prospective sentinel lymph node database at Wake Forest Baptist Health and analyzed their treatment and survival. Of 92 patients, 24 (26.1%) underwent mastectomy, 22 (23...
August 1, 2017: American Surgeon
https://www.readbyqxmd.com/read/28783712/machine-learning-for-predicting-lifespan-extending-chemical-compounds
#7
Diogo G Barardo, Danielle Newby, Daniel Thornton, Taravat Ghafourian, João Pedro de Magalhães, Alex A Freitas
Increasing age is a risk factor for many diseases; therefore developing pharmacological interventions that slow down ageing and consequently postpone the onset of many age-related diseases is highly desirable. In this work we analyse data from the DrugAge database, which contains chemical compounds and their effect on the lifespan of model organisms. Predictive models were built using the machine learning method random forests to predict whether or not a chemical compound will increase Caenorhabditis elegans' lifespan, using as features Gene Ontology (GO) terms annotated for proteins targeted by the compounds and chemical descriptors calculated from each compound's chemical structure...
July 18, 2017: Aging
https://www.readbyqxmd.com/read/28781056/measuring-functional-arm-movement-after-stroke-using-a-single-wrist-worn-sensor-and-machine-learning
#8
Elaine M Bochniewicz, Geoff Emmer, Adam McLeod, Jessica Barth, Alexander W Dromerick, Peter Lum
BACKGROUND AND PURPOSE: Trials of restorative therapies after stroke and clinical rehabilitation require relevant and objective efficacy end points; real-world upper extremity (UE) functional use is an attractive candidate. We present a novel, inexpensive, and feasible method for separating UE functional use from nonfunctional movement after stroke using a single wrist-worn accelerometer. METHODS: Ten controls and 10 individuals with stroke performed a series of minimally structured activities while simultaneously being videotaped and wearing a sensor on each wrist that captured the linear acceleration and angular velocity of their UEs...
August 4, 2017: Journal of Stroke and Cerebrovascular Diseases: the Official Journal of National Stroke Association
https://www.readbyqxmd.com/read/28767418/cancer-specific-evaluation-system-canes-a-high-accuracy-platform-for-preclinical-single-multi-biomarker-discovery
#9
Min-Seok Kwon, Seungyoon Nam, Sungyoung Lee, Young Zoo Ahn, Hae Ryung Chang, Yon Hui Kim, Taesung Park
The recent creation of enormous, cancer-related "Big Data" public depositories represents a powerful means for understanding tumorigenesis. However, a consistently accurate system for clinically evaluating single/multi-biomarkers remains lacking, and it has been asserted that oft-failed clinical advancement of biomarkers occurs within the very early stages of biomarker assessment. To address these challenges, we developed a clinically testable, web-based tool, CANcer-specific single/multi-biomarker Evaluation System (CANES), to evaluate biomarker effectiveness, across 2,134 whole transcriptome datasets, from 94,147 biological samples (from 18 tumor types)...
July 15, 2017: Oncotarget
https://www.readbyqxmd.com/read/28761270/medicinal-plants-and-bone-healing
#10
REVIEW
Vibha Singh
Fracture is defined as complete or incomplete separation in the continuity of bone Fracture healing is a complex physiological process that involves the coordinated participation of hematopoietic and immune cells within bone marrow. It conjunction with vascular and skeletal cell precursors it also includes mesenchymal stem cells which are recruited from the circulation and the surrounding tissues. It is estimated that 80% of the population in developing countries still rely on the traditional herbal medicines...
January 2017: National Journal of Maxillofacial Surgery
https://www.readbyqxmd.com/read/28759136/extracorporeal-shock-wave-therapy-for-chronic-wounds-a-systematic-review-and-meta-analysis-of-randomized-controlled-trials
#11
Li Zhang, Changshui Weng, Zhanbo Zhao, Xiaobing Fu
A growing number of clinical studies demonstrate that extracorporeal shock wave therapy is a feasible noninvasive method for improving chronic wound healing. This systematic review and meta-analysis aimed to assess the effectiveness of extracorporeal shock wave therapy compared with that of the standard care treatment for the healing of chronic wounds, irrespective of etiology, in clinical practice. Randomized controlled trials that investigated the effect of extracorporeal shock wave therapy on chronic wounds with different etiologies from 2000 to 2017 were included in this review...
July 31, 2017: Wound Repair and Regeneration
https://www.readbyqxmd.com/read/28742052/a-semi-analytical-model-of-a-time-reversal-cavity-for-high-amplitude-focused-ultrasound-applications
#12
J Robin, M Tanter, M Pernot
Time reversal cavities (TRC) have been proposed as an efficient approach for 3D ultrasound therapy. They allow the precise spatio-temporal focusing of high-power ultrasound pulses within a large region of interest with a low number of transducers. Leaky TRCs are usually built by placing a multiple scattering medium, such as a random rod forest, in a reverberating cavity, and the final peak pressure gain of the device only depends on the temporal length of its impulse response. Such multiple scattering in a reverberating cavity is a complex phenomenon, and optimisation of the device's gain is usually a cumbersome process, mostly empirical, and requiring numerical simulations with extremely long computation times...
September 5, 2017: Physics in Medicine and Biology
https://www.readbyqxmd.com/read/28686281/identification-of-microrna-precursors-using-reduced-and-hybrid-features
#13
Asad Khan, Sajid Shah, Fazli Wahid, Fiaz Gul Khan, Saima Jabeen
MicroRNAs (also called miRNAs) are a group of short non-coding RNA molecules. They play a vital role in the gene expression of transcriptional and post-transcriptional processes. However, abnormality of their expression has been observed in cancer, heart diseases and nervous system disorders. Therefore for basic research and microRNA based therapy, it is imperative to separate real pre-miRNAs from false ones (hairpin sequences similar to pre-miRNA stem loops). Different conservation and machine learning methods have been applied for the identification of miRNAs...
July 25, 2017: Molecular BioSystems
https://www.readbyqxmd.com/read/28673196/magnetic-resonance-and-ultrastructural-characterization-of-pegylation-associated-vacuolation-in-nonclinical-models
#14
Thomas Forest, Qiuwei Xu, Sabu Kuruvilla, Heather Vu, Katerina Vlasakova, Warren E Glaab, Cathy Hines, Song Xun
Conjugation with polyethylene glycol (PEG) is a strategy for improving the pharmaceutical properties of therapeutic proteins. In nonclinical studies of PEGylated compounds, microscopic tissue vacuolation is often observed, characterized ultrastructurally in this report by lysosomal distension. Although PEGylation-associated vacuolation appears to be of limited toxicologic concern when alternative therapies are limited, the risk-benefit considerations may be impacted by uncertainty about reversibility, lack of methods for monitoring PEG accumulation in vivo without biopsy, and the variability in tissues affected depending on species studied...
January 1, 2017: Toxicologic Pathology
https://www.readbyqxmd.com/read/28656273/network-analysis-of-hbv%C3%A2-and-hcv%C3%A2-induced-hepatocellular-carcinoma-based-on-random-forest-and-monte-carlo-cross%C3%A2-validation
#15
Shan-Na Zhao, Ling-Ling Liu, Zhi-Ping Lv, Xiao-Hua Wang, Cheng-Hong Wang
Hepatocellular carcinoma (HCC) is one of the leading causes of cancer‑associated mortality worldwide. Hepatitis B virus (HBV) and hepatitis C virus (HCV) are two common risk factors for HCC. The majority of patients with HCC present at an advanced stage and are refractory to therapy. It is important to identify a method for efficient diagnosis at early stage. In the present study gene expression profile data, generated from microarray data, were pretreated according to the annotation files. The genes were mapped to pathways of Ingenuity Pathways Analysis...
September 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/28641531/application-of-alphaviral-vectors-for-immunomodulation-in-cancer-therapy
#16
Anna Zajakina, Karina Spunde, Kenneth Lundstrom
BACKGROUND: The lack of specific and efficient cancer therapies has influenced the development of novel approaches, such as immunotherapy, which from its original application of immunogenic protein delivery has developed into the use of more sophisticated recombinant gene delivery methods to achieve better safety and efficacy profiles. This approach involves viral and non-viral delivery systems. METHODS: Expression vectors have been engineered for alphaviruses, including Semliki Forest virus, Sindbis virus and Venezuelan equine encephalitis virus...
June 21, 2017: Current Pharmaceutical Design
https://www.readbyqxmd.com/read/28624625/a-formalin-fixed-paraffin-embedded-ffpe-based-prognostic-signature-to-predict-metastasis-in-clinically-low-risk-stage-i-ii-microsatellite-stable-colorectal-cancer
#17
Yee Syuen Low, Christopher Blöcker, John R McPherson, See Aik Tang, Ying Ying Cheng, Joyner Y S Wong, Clarinda Chua, Tony K H Lim, Choong Leong Tang, Min Hoe Chew, Patrick Tan, Iain B Tan, Steven G Rozen, Peh Yean Cheah
Approximately 20% early-stage (I/II) colorectal cancer (CRC) patients develop metastases despite curative surgery. We aim to develop a formalin-fixed and paraffin-embedded (FFPE)-based predictor of metastases in early-stage, clinically-defined low risk, microsatellite-stable (MSS) CRC patients. We considered genome-wide mRNA and miRNA expression and mutation status of 20 genes assayed in 150 fresh-frozen tumours with known metastasis status. We selected 193 genes for further analysis using NanoString nCounter arrays on corresponding FFPE tumours...
September 10, 2017: Cancer Letters
https://www.readbyqxmd.com/read/28611205/mouse-pdx-trial-suggests-synergy-of-concurrent-inhibition-of-raf-and-egfr-in-colorectal-cancer-with-braf-or-kras-mutations
#18
Yung-Mae M Yao, Gregory P Donoho, Philip W Iversen, Youyan Zhang, Robert D Van Horn, Amelie Forest, Ruslan D Novosiadly, Yue Wang Webster, Philip Ebert, Steven Bray, Jason C Ting, Amit Aggarwal, James R Henry, Ramon V Tiu, Gregory D Plowman, Sheng-Bin Peng
Purpose: To evaluate the antitumor efficacy of cetuximab in combination with LSN3074753, an analog of LY3009120 and pan-RAF inhibitor in 79 colorectal cancer patient-derived xenograft (PDX) models.Experimental Design: Seventy-nine well-characterized colorectal cancer PDX models were employed to conduct a single mouse per treatment group (n = 1) trial.Results: Consistent with clinical results, cetuximab was efficacious in wild-type KRAS and BRAF PDX models, with an overall response rate of 6.3% and disease control rate (DCR) of 20...
June 13, 2017: Clinical Cancer Research: An Official Journal of the American Association for Cancer Research
https://www.readbyqxmd.com/read/28604132/the-efficacy-of-methotrexate-in-the-treatment-of-en-coup-de-sabre-linear-morphea-subtype
#19
Ploysyne Rattanakaemakorn, Joseph Jorizzo
BACKGROUND: En coup de sabre is a rare subtype of linear morphea, located on the forehead or frontoparietal scalp. Systemic treatment of localized morphea with methotrexate has been reported in a few clinical reports. However, there are no case series using methotrexate treatment for En coup de sabre. OBJECTIVE: To evaluate the efficacy and tolerability of methotrexate in the treatment of en coup de sabre linear morphea subtype. METHOD: A retrospective chart review was performed for pediatric and the adult patients with en coup de sabre evaluated in the Dermatology Clinic at Wake Forest University School of Medicine treated with methotrexate...
June 12, 2017: Journal of Dermatological Treatment
https://www.readbyqxmd.com/read/28584444/quantitative-structure-activity-relationship-study-of-the-anti-hepatitis-peptides-employing-random-forests-and-extra-trees-regressors
#20
Gunjan Mishra, Deepak Sehgal, Jayaraman K Valadi
Antimicrobial peptides are host defense peptides being viewed as replacement to broad-spectrum antibiotics due to varied advantages. Hepatitis is the commonest infectious disease of liver, affecting 500 million globally with reported adverse side effects in treatment therapy. Antimicrobial peptides active against hepatitis are called as anti-hepatitis peptides (AHP). In current work, we present Extratrees and Random Forests based Quantitative Structure Activity Relationship (QSAR) regression modeling using extracted sequence based descriptors for prediction of the anti-hepatitis activity...
2017: Bioinformation
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