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https://www.readbyqxmd.com/read/28783712/machine-learning-for-predicting-lifespan-extending-chemical-compounds
#1
Diogo G Barardo, Danielle Newby, Daniel Thornton, Taravat Ghafourian, João Pedro de Magalhães, Alex A Freitas
Increasing age is a risk factor for many diseases; therefore developing pharmacological interventions that slow down ageing and consequently postpone the onset of many age-related diseases is highly desirable. In this work we analyse data from the DrugAge database, which contains chemical compounds and their effect on the lifespan of model organisms. Predictive models were built using the machine learning method random forests to predict whether or not a chemical compound will increase Caenorhabditis elegans' lifespan, using as features Gene Ontology (GO) terms annotated for proteins targeted by the compounds and chemical descriptors calculated from each compound's chemical structure...
July 18, 2017: Aging
https://www.readbyqxmd.com/read/28781056/measuring-functional-arm-movement-after-stroke-using-a-single-wrist-worn-sensor-and-machine-learning
#2
Elaine M Bochniewicz, Geoff Emmer, Adam McLeod, Jessica Barth, Alexander W Dromerick, Peter Lum
BACKGROUND AND PURPOSE: Trials of restorative therapies after stroke and clinical rehabilitation require relevant and objective efficacy end points; real-world upper extremity (UE) functional use is an attractive candidate. We present a novel, inexpensive, and feasible method for separating UE functional use from nonfunctional movement after stroke using a single wrist-worn accelerometer. METHODS: Ten controls and 10 individuals with stroke performed a series of minimally structured activities while simultaneously being videotaped and wearing a sensor on each wrist that captured the linear acceleration and angular velocity of their UEs...
August 4, 2017: Journal of Stroke and Cerebrovascular Diseases: the Official Journal of National Stroke Association
https://www.readbyqxmd.com/read/28767418/cancer-specific-evaluation-system-canes-a-high-accuracy-platform-for-preclinical-single-multi-biomarker-discovery
#3
Min-Seok Kwon, Seungyoon Nam, Sungyoung Lee, Young Zoo Ahn, Hae Ryung Chang, Yon Hui Kim, Taesung Park
The recent creation of enormous, cancer-related "Big Data" public depositories represents a powerful means for understanding tumorigenesis. However, a consistently accurate system for clinically evaluating single/multi-biomarkers remains lacking, and it has been asserted that oft-failed clinical advancement of biomarkers occurs within the very early stages of biomarker assessment. To address these challenges, we developed a clinically testable, web-based tool, CANcer-specific single/multi-biomarker Evaluation System (CANES), to evaluate biomarker effectiveness, across 2,134 whole transcriptome datasets, from 94,147 biological samples (from 18 tumor types)...
July 15, 2017: Oncotarget
https://www.readbyqxmd.com/read/28761270/medicinal-plants-and-bone-healing
#4
REVIEW
Vibha Singh
Fracture is defined as complete or incomplete separation in the continuity of bone Fracture healing is a complex physiological process that involves the coordinated participation of hematopoietic and immune cells within bone marrow. It conjunction with vascular and skeletal cell precursors it also includes mesenchymal stem cells which are recruited from the circulation and the surrounding tissues. It is estimated that 80% of the population in developing countries still rely on the traditional herbal medicines...
January 2017: National Journal of Maxillofacial Surgery
https://www.readbyqxmd.com/read/28759136/extracorporeal-shock-wave-therapy-for-chronic-wounds-a-systematic-review-and-meta-analysis-of-randomized-controlled-trials
#5
Li Zhang, Changshui Weng, Zhanbo Zhao, Xiaobing Fu
A growing number of clinical studies demonstrate that extracorporeal shock wave therapy is a feasible noninvasive method for improving chronic wound healing. This systematic review and meta-analysis aimed to assess the effectiveness of extracorporeal shock wave therapy compared with that of the standard care treatment for the healing of chronic wounds, irrespective of etiology, in clinical practice. Randomized controlled trials that investigated the effect of extracorporeal shock wave therapy on chronic wounds with different etiologies from 2000 to 2017 were included in this review...
July 31, 2017: Wound Repair and Regeneration
https://www.readbyqxmd.com/read/28742052/a-semi-analytical-model-of-time-reversal-cavity-for-high-amplitude-focused-ultrasound-applications
#6
Justine Robin, Mickael Tanter, Mathieu Pernot
Time reversal cavities (TRC) have been proposed as an efficient approach for 3D ultrasound therapy. They indeed allow precise spatio-temporal focusing of high power ultrasound pulses within a large region of interest with a low number of transducers. Leaky TRCs are usually built by placing a multiple scattering medium such as a random rods forest in a reverberating cavity, and the final peak pressure gain of the device only depends on the temporal length of its impulse response. Such multiple scattering in a reverberating cavity is a complex phenomenon, and the optimization of the device's gain is usually a cumbersome process, mostly empirical, and requiring numerical simulations with extremely long computational times...
July 25, 2017: Physics in Medicine and Biology
https://www.readbyqxmd.com/read/28686281/identification-of-microrna-precursors-using-reduced-and-hybrid-features
#7
Asad Khan, Sajid Shah, Fazli Wahid, Fiaz Gul Khan, Saima Jabeen
MicroRNAs (also called miRNAs) are a group of short non-coding RNA molecules. They play a vital role in the gene expression of transcriptional and post-transcriptional processes. However, abnormality of their expression has been observed in cancer, heart diseases and nervous system disorders. Therefore for basic research and microRNA based therapy, it is imperative to separate real pre-miRNAs from false ones (hairpin sequences similar to pre-miRNA stem loops). Different conservation and machine learning methods have been applied for the identification of miRNAs...
July 25, 2017: Molecular BioSystems
https://www.readbyqxmd.com/read/28673196/magnetic-resonance-and-ultrastructural-characterization-of-pegylation-associated-vacuolation-in-nonclinical-models
#8
Thomas Forest, Qiuwei Xu, Sabu Kuruvilla, Heather Vu, Katerina Vlasakova, Warren E Glaab, Cathy Hines, Song Xun
Conjugation with polyethylene glycol (PEG) is a strategy for improving the pharmaceutical properties of therapeutic proteins. In nonclinical studies of PEGylated compounds, microscopic tissue vacuolation is often observed, characterized ultrastructurally in this report by lysosomal distension. Although PEGylation-associated vacuolation appears to be of limited toxicologic concern when alternative therapies are limited, the risk-benefit considerations may be impacted by uncertainty about reversibility, lack of methods for monitoring PEG accumulation in vivo without biopsy, and the variability in tissues affected depending on species studied...
January 1, 2017: Toxicologic Pathology
https://www.readbyqxmd.com/read/28656273/network-analysis-of-hbv%C3%A2-and-hcv%C3%A2-induced-hepatocellular-carcinoma-based-on-random-forest-and-monte-carlo-cross%C3%A2-validation
#9
Shan-Na Zhao, Ling-Ling Liu, Zhi-Ping Lv, Xiao-Hua Wang, Cheng-Hong Wang
Hepatocellular carcinoma (HCC) is one of the leading causes of cancer‑associated mortality worldwide. Hepatitis B virus (HBV) and hepatitis C virus (HCV) are two common risk factors for HCC. The majority of patients with HCC present at an advanced stage and are refractory to therapy. It is important to identify a method for efficient diagnosis at early stage. In the present study gene expression profile data, generated from microarray data, were pretreated according to the annotation files. The genes were mapped to pathways of Ingenuity Pathways Analysis...
September 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/28641531/application-of-alphaviral-vectors-for-immunomodulation-in-cancer-therapy
#10
Anna Zajakina, Karina Spunde, Kenneth Lundstrom
BACKGROUND: The lack of specific and efficient cancer therapies has influenced the development of novel approaches, such as immunotherapy, which from its original application of immunogenic protein delivery has developed into the use of more sophisticated recombinant gene delivery methods to achieve better safety and efficacy profiles. This approach involves viral and non-viral delivery systems. METHODS: Expression vectors have been engineered for alphaviruses, including Semliki Forest virus, Sindbis virus and Venezuelan equine encephalitis virus...
June 21, 2017: Current Pharmaceutical Design
https://www.readbyqxmd.com/read/28624625/a-formalin-fixed-paraffin-embedded-ffpe-based-prognostic-signature-to-predict-metastasis-in-clinically-low-risk-stage-i-ii-microsatellite-stable-colorectal-cancer
#11
Yee Syuen Low, Christopher Blöcker, John R McPherson, See Aik Tang, Ying Ying Cheng, Joyner Y S Wong, Clarinda Chua, Tony K H Lim, Choong Leong Tang, Min Hoe Chew, Patrick Tan, Iain B Tan, Steven G Rozen, Peh Yean Cheah
Approximately 20% early-stage (I/II) colorectal cancer (CRC) patients develop metastases despite curative surgery. We aim to develop a formalin-fixed and paraffin-embedded (FFPE)-based predictor of metastases in early-stage, clinically-defined low risk, microsatellite-stable (MSS) CRC patients. We considered genome-wide mRNA and miRNA expression and mutation status of 20 genes assayed in 150 fresh-frozen tumours with known metastasis status. We selected 193 genes for further analysis using NanoString nCounter arrays on corresponding FFPE tumours...
September 10, 2017: Cancer Letters
https://www.readbyqxmd.com/read/28611205/mouse-pdx-trial-suggests-synergy-of-concurrent-inhibition-of-raf-and-egfr-in-colorectal-cancer-with-braf-or-kras-mutations
#12
Yung-Mae M Yao, Gregory P Donoho, Philip Iversen, Youyan Zhang, Robert D Van Horn, Amelie Forest, Ruslan Novosiadly, Yue Webster, Ebert J Philip, Steven M Bray, Jason C Ting, Amit Aggarwal, James R Henry, Ramon V Tiu, Gregory D Plowman, Sheng-Bin Peng
Purpose: It is to evaluate the anti-tumor efficacy of cetuximab in combination with LSN3074753, an analogue of LY3009120 and pan-RAF inhibitor in 79 colorectal cancer (CRC) patient derived xenograft (PDX) models.<br />Experimental Design: 79 well characterized CRC PDX models were employed to conduct a single mouse per treatment group (n=1) trial.<br />Results: Consistent with clinical results, cetuximab was efficacious in wild type KRAS and BRAF PDX models, with an overall response rate (ORR) of 6...
June 13, 2017: Clinical Cancer Research: An Official Journal of the American Association for Cancer Research
https://www.readbyqxmd.com/read/28604132/the-efficacy-of-methotrexate-in-the-treatment-of-en-coup-de-sabre-linear-morphea-subtype
#13
Ploysyne Rattanakaemakorn, Joseph Jorizzo
BACKGROUND: En coup de sabre is a rare subtype of linear morphea, located on the forehead or frontoparietal scalp. Systemic treatment of localized morphea with methotrexate has been reported in a few clinical reports. However, there are no case series using methotrexate treatment for En coup de sabre. OBJECTIVE: To evaluate the efficacy and tolerability of methotrexate in the treatment of en coup de sabre linear morphea subtype. METHOD: A retrospective chart review was performed for pediatric and the adult patients with en coup de sabre evaluated in the Dermatology Clinic at Wake Forest University School of Medicine treated with methotrexate...
June 12, 2017: Journal of Dermatological Treatment
https://www.readbyqxmd.com/read/28584444/quantitative-structure-activity-relationship-study-of-the-anti-hepatitis-peptides-employing-random-forests-and-extra-trees-regressors
#14
Gunjan Mishra, Deepak Sehgal, Jayaraman K Valadi
Antimicrobial peptides are host defense peptides being viewed as replacement to broad-spectrum antibiotics due to varied advantages. Hepatitis is the commonest infectious disease of liver, affecting 500 million globally with reported adverse side effects in treatment therapy. Antimicrobial peptides active against hepatitis are called as anti-hepatitis peptides (AHP). In current work, we present Extratrees and Random Forests based Quantitative Structure Activity Relationship (QSAR) regression modeling using extracted sequence based descriptors for prediction of the anti-hepatitis activity...
2017: Bioinformation
https://www.readbyqxmd.com/read/28583437/prediction-of-synergistic-anti-cancer-drug-combinations-based-on-drug-target-network-and-drug-induced-gene-expression-profiles
#15
Xiangyi Li, Yingjie Xu, Hui Cui, Tao Huang, Disong Wang, Baofeng Lian, Wei Li, Guangrong Qin, Lanming Chen, Lu Xie
OBJECTIVE: Synergistic drug combinations are promising therapies for cancer treatment. However, effective prediction of synergistic drug combinations is quite challenging as mechanisms of drug synergism are still unclear. Various features such as drug response, and target networks may contribute to prediction of synergistic drug combinations. In this study, we aimed to construct a computational model to predict synergistic drug combinations. METHODS: We designed drug physicochemical features and network features, including drug chemical structure similarity, target distance in protein-protein network and targeted pathway similarity...
June 2, 2017: Artificial Intelligence in Medicine
https://www.readbyqxmd.com/read/28557674/self-hypnosis-classes-to-enhance-the-quality-of-life-of-breast-cancer-patients
#16
Holly Forester-Miller
The Healing Skills Project, consisting of five, four-session self-hypnosis classes, was a pilot-study to evaluate the impact of self-hypnosis on the quality of life for breast cancer patients. The impact of self-hypnosis in women with breast cancer was measured using a self-report instrument, the Functional Assessment of Cancer Therapy-Breast, pre- and post-intervention (Brady, et al., 1997; Maratia, Cedillo, & Rejas, 2016). After employing the self-hypnosis interventions, statistically significant changes were noted on 16 of the 36 items, despite the small sample size (N = 23)...
July 2017: American Journal of Clinical Hypnosis
https://www.readbyqxmd.com/read/28554959/longitudinal-assessment-of-excessive-daytime-sleepiness-in-early-parkinson-s-disease
#17
MULTICENTER STUDY
Amy W Amara, Lama M Chahine, Chelsea Caspell-Garcia, Jeffrey D Long, Christopher Coffey, Birgit Högl, Aleksandar Videnovic, Alex Iranzo, Geert Mayer, Nancy Foldvary-Schaefer, Ron Postuma, Wolfgang Oertel, Shirley Lasch, Ken Marek, Tanya Simuni
BACKGROUND: Excessive daytime sleepiness (EDS) is common and disabling in Parkinson's disease (PD). Predictors of EDS are unclear, and data on biological correlates of EDS in PD are limited. We investigated clinical, imaging and biological variables associated with longitudinal changes in sleepiness in early PD. METHODS: The Parkinson's Progression Markers Initiative is a prospective cohort study evaluating progression markers in participants with PD who are unmedicated at baseline (n=423) and healthy controls (HC; n=196)...
August 2017: Journal of Neurology, Neurosurgery, and Psychiatry
https://www.readbyqxmd.com/read/28541882/web-app-based-patient-education-in-psoriasis-a-randomized-controlled-trial
#18
Spencer D Hawkins, Steven Barilla, Steven R Feldman
PURPOSE: Patients report wanting more information about psoriasis and clear expectations from the onset of therapy. Dermatologists do not think patients receive or internalize adequate information. There isa need for further explanation of treatment regimens to increase knowledge, compliance, and patient satisfaction. Recent advancements in web technology have the potential to improve these psoriasis outcomes. METHODS: A web based application was created to educate psoriasis patients using video, graphics, and textual information...
April 15, 2017: Dermatology Online Journal
https://www.readbyqxmd.com/read/28534665/-i-look-at-my-own-forest-and-fields-in-a-different-way-the-lived-experience-of-nature-based-therapy-in-a-therapy-garden-when-suffering-from-stress-related-illness
#19
Ulrik Sidenius, Ulrika K Stigsdotter, Dorthe Varning Poulsen, Terese Bondas
Evidence confirms that nature-based therapy (NBT) has a positive effect on people with mental illnesses. However, there is a lack of evidence on the meaning of NBT for specific patient groups. The Nacadia® Therapy Garden was designed according to an evidence-based design process, and an NBT programme was developed. The aim of the study was to illuminate the phenomenon of participants' lived experience of the NBT in Nacadia. Fourteen participants took part in semi-structured interviews (SSIs), and by way of reflective lifeworld research, the SSIs were analysed to identify and describe the meanings of the phenomenon...
December 2017: International Journal of Qualitative Studies on Health and Well-being
https://www.readbyqxmd.com/read/28533050/dual-core-steered-non-rigid-registration-for-multi-modal-images-via-bi-directional-image-synthesis
#20
Xiaohuan Cao, Jianhua Yang, Yaozong Gao, Yanrong Guo, Guorong Wu, Dinggang Shen
In prostate cancer radiotherapy, computed tomography (CT) is widely used for dose planning purposes. However, because CT has low soft tissue contrast, it makes manual contouring difficult for major pelvic organs. In contrast, magnetic resonance imaging (MRI) provides high soft tissue contrast, which makes it ideal for accurate manual contouring. Therefore, the contouring accuracy on CT can be significantly improved if the contours in MRI can be mapped to CT domain by registering MRI with CT of the same subject, which would eventually lead to high treatment efficacy...
May 13, 2017: Medical Image Analysis
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