Xianhao Wu, Rui Tao, Zhiyan Sun, Tianyao Zhang, Xingyue Li, Yuan Yuan, Shaowen Zheng, Can Cao, Zhaohui Zhang, Xiaoyan Zhao, Pei Yang
Epidermal growth factor receptor (EGFR) plays a pivotal role in the initiation and progression of gliomas. In particular, in glioblastoma, EGFR amplification emerges as a catalyst for invasion, proliferation, and resistance to radiotherapy and chemotherapy. Current approaches are not capable of providing rapid diagnostic results of molecular pathology. In this study, we propose a terahertz spectroscopic approach for predicting the EGFR amplification status of gliomas for the first time. A machine learning model was constructed using the terahertz response of the measured glioma tissues, including the absorption coefficient, refractive index, and dielectric loss tangent...
April 26, 2024: Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy