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Colorectal cancer screening

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https://www.readbyqxmd.com/read/29334136/a-bayesian-network-meta-analysis-efficacy-of-air-insufflation-co2-insufflation-water-exchange-and-water-immersion-in-colonoscopy
#1
REVIEW
Zhen Zhang, Yifeng Wu, Guangge Sun, Jing Zhang, Jiaxin Li, Chongyang Qiu, Xin Zheng, Botao Wang, Lei Yang, Ximo Wang
BACKGROUND: Colonoscopy is one of the excellent tools for screening colorectal cancer. There were four colonoscopy techniques containing air insufflation, CO2 insufflation, water exchange, and water immersion. Some studies reported that these methods are better than the criterion standard (air insufflation), while some studies showed not. In order to evaluate the efficacy of four colonoscopy techniques, a network meta-analysis was performed in present study. METHODS: We searched randomized controlled trials (RCTs) published up to September 2017 from PubMed, Embase, Cochrane library, and Web of Science...
January 15, 2018: Digestive Endoscopy: Official Journal of the Japan Gastroenterological Endoscopy Society
https://www.readbyqxmd.com/read/29333424/anatomical-distribution-and-detection-rate-of-colorectal-neoplasms-according-to-age-in-the-colonoscopic-screening-of-a-korean-population
#2
Suk-Young Lee, Wan Hee Song, Sang Cheul Oh, Byung-Wook Min, Sun Il Lee
Purpose: Because data as a basis for the determination of proper age and modality for screening of colorectal neoplasms is lacking, we evaluated detection rates and anatomical distribution of colorectal neoplasms according to age in healthy individuals who underwent total colonoscopy for health checkup. Methods: A total of 16,100 cases that had received the colonoscopic examination from January to December in 2014 were analyzed. The total number of individuals who received total colonoscopy were divided by the number of individuals harboring colorectal adenoma to calculate the detection rate of colorectal adenoma...
January 2018: Annals of Surgical Treatment and Research
https://www.readbyqxmd.com/read/29330641/characteristics-of-mutyh-variants-in-japanese-colorectal-polyposis-patients
#3
Misato Takao, Tatsuro Yamaguchi, Hidetaka Eguchi, Yuhki Tada, Masakazu Kohda, Koichi Koizumi, Shin-Ichiro Horiguchi, Yasushi Okazaki, Hideyuki Ishida
BACKGROUND: The base excision repair gene MUTYH is the causative gene of colorectal polyposis syndrome, which is an autosomal recessive disorder associated with a high risk of colorectal cancer. Since few studies have investigated the genotype-phenotype association in Japanese patients with MUTYH variants, the aim of this study was to clarify the clinicopathological findings in Japanese patients with MUTYH gene variants who were detected by screening causative genes associated with hereditary colorectal polyposis...
January 12, 2018: International Journal of Clinical Oncology
https://www.readbyqxmd.com/read/29329588/accuracy-of-four-mononucleotide-repeat-markers-for-the-identification-of-dna-mismatch-repair-deficiency-in-solid-tumors
#4
Yuko Takehara, Takeshi Nagasaka, Akihiro Nyuya, Tomoko Haruma, Junko Haraga, Yoshiko Mori, Keiichiro Nakamura, Toshiyoshi Fujiwara, C Richard Boland, Ajay Goel
BACKGROUND: To screen tumors with microsatellite instability (MSI) arising due to DNA mismatch repair deficiency (dMMR), a panel of five quasi-monomorphic mononucleotide-repeat markers amplified in a multiplex PCR (Pentaplex) are commonly used. In spite of its several strengths, the pentaplex assay is not robust at detecting the loss of MSH6-deficiency (dMSH6). In order to overcome this challenge, we designed this study to develop and optimize a panel of four quasi-monomorphic mononucleotide-repeat markers (Tetraplex) for identifying solid tumors with dMMR, especially dMSH6...
January 12, 2018: Journal of Translational Medicine
https://www.readbyqxmd.com/read/29327043/association-of-oral-microbiome-with-risk-for-incident-head-and-neck-squamous-cell-cancer
#5
Richard B Hayes, Jiyoung Ahn, Xiaozhou Fan, Brandilyn A Peters, Yingfei Ma, Liying Yang, Ilir Agalliu, Robert D Burk, Ian Ganly, Mark P Purdue, Neal D Freedman, Susan M Gapstur, Zhiheng Pei
Importance: Case-control studies show a possible relationship between oral bacteria and head and neck squamous cell cancer (HNSCC). Prospective studies are needed to examine the temporal relationship between oral microbiome and subsequent risk of HNSCC. Objective: To prospectively examine associations between the oral microbiome and incident HNSCC. Design, Setting, and Participants: This nested case-control study was carried out in 2 prospective cohort studies: the American Cancer Society Cancer Prevention Study II Nutrition Cohort (CPS-II) and the Prostate, Lung, Colorectal, and Ovarian Cancer Screening Trial (PLCO)...
January 11, 2018: JAMA Oncology
https://www.readbyqxmd.com/read/29324557/factors-influencing-participation-in-fecal-occult-blood-testing-to-screen-for-colorectal-cancer-in-australia-a-scoping-review-protocol
#6
Simone Lee, Andrea Miller
The objective of this scoping review is to examine and map the evidence on the range of factors influencing a person's decision to screen or not screen for colorectal cancer using a fecal occult blood test (FOBT) in Australia, with the view to identifying gaps in the research and informing appropriate questions for future systematic reviews.The question of this review is: what evidence is available around the barriers and facilitators that influence an individual's decision to screen or not screen for colorectal cancer using a fecal occult blood test in Australia?...
January 2018: JBI Database of Systematic Reviews and Implementation Reports
https://www.readbyqxmd.com/read/29322354/mutations-of-key-driver-genes-in-colorectal-cancer-progression-and-metastasis
#7
REVIEW
Dongdong Huang, Wenjie Sun, Yuwei Zhou, Peiwei Li, Fang Chen, Hanwen Chen, Dajing Xia, Enping Xu, Maode Lai, Yihua Wu, Honghe Zhang
The association between mutations of key driver genes and colorectal cancer (CRC) metastasis has been investigated by many studies. However, the results of these studies have been contradictory. Here, we perform a comprehensive analysis to screen key driver genes from the TCGA database and validate the roles of these mutations in CRC metastasis. Using bioinformatics analysis, we identified six key driver genes, namely APC, KRAS, BRAF, PIK3CA, SMAD4 and p53. Through a systematic search, 120 articles published by November 30, 2017, were included, which all showed roles for these gene mutations in CRC metastasis...
January 10, 2018: Cancer Metastasis Reviews
https://www.readbyqxmd.com/read/29320335/physician-intervention-and-chinese-americans-colorectal-cancer-screening
#8
Judy Huei-Yu Wang, Grace X Ma, Wenchi Liang, Yin Tan, Kepher H Makambi, Roucheng Dong, Sally W Vernon, Shin-Ping Tu, Jeanne S Mandelblatt
OBJECTIVE: We conducted a cluster-randomized trial evaluating an intervention that trained Chinese-American primary care physicians to increase their Chinese patients' colorectal cancer (CRC) screening. METHODS: Twenty-five physicians (13 randomized to the intervention arm and 12 to the control arm) and 479 of their patients (aged 50-75 and nonadherent to CRC screening guidelines) were enrolled. The intervention, guided by Social Cognitive Theory, included a communication guide and 2 in-office training sessions to enhance physicians' efficacy in com- municating CRC screening with patients...
January 1, 2018: American Journal of Health Behavior
https://www.readbyqxmd.com/read/29319331/-simple-and-easy-providers-and-latinos-perceptions-of-the-fecal-immunochemical-test-fit-for-colorectal-cancer-screening
#9
Claudia X Aguado Loi, Dinorah Martinez Tyson, Enmanuel A Chavarria, Liliana Gutierrez, Lynne Klasko, Stacy Davis, Diana Lopez, Tracy Johns, Cathy D Meade, Clement K Gwede
OBJECTIVE: Colorectal cancer (CRC) screening efforts have effectively reduced CRC morbidity and mortality, yet screening remains relatively low among Latinos. The study's purpose was to document the awareness/knowledge of Fecal Immunochemical Test (FIT) among Latinos, gain better understanding of patient and health care provider perceptions about FIT, and explore the feasibility of adoption/uptake. DESIGN/METHODS: The study was guided by qualitative, ethnography design and methods...
January 10, 2018: Ethnicity & Health
https://www.readbyqxmd.com/read/29317271/temporal-trends-in-postcolonoscopy-colorectal-cancer-rates-in-screen-eligible-persons-a-population-based-study
#10
Sanjay K Murthy, Eric I Benchimol, Jill Tinmouth, Paul D James, Robin Ducharme, Alaa Rostom, Catherine Dubé
BACKGROUND AND AIMS: Colorectal cancers (CRCs) diagnosed between 6 and 36 months after colonoscopy, termed postcolonoscopy CRCs (PCCRCs), arise primarily due to missed or inadequately treated neoplasms during colonoscopy. Quality indicators and technological advances have been introduced to colonoscopy practice that should have reduced the PCCRC rate over time. We assessed temporal trends in the population rate of PCCRC as a measure of changing colonoscopy quality. METHODS: We conducted a population-based retrospective cohort study of 50- to 74-year-old people without major risk factors for CRC who underwent complete colonoscopy in Ontario, Canada between 1996 and 2010...
January 6, 2018: Gastrointestinal Endoscopy
https://www.readbyqxmd.com/read/29315389/cancer-screening-guidelines-and-policy-making-15-years-of-experience-in-cancer-screening-guideline-development-in-japan
#11
Chisato Hamashima
Cancer deaths have remained a heavy burden in Japan, thus cancer screening has been anticipated to be a practical strategy for reducing mortality from cancers. The Basic Plan to Promote Cancer Control Program published in 2006 stated that evidence-based cancer screening is required. At the conception of national cancer screening programs, there were no cancer screening assessments. From 1998 to 2001, Hisamichi formed committees for the assessment of cancer screening and published three reports. These reports were the cornerstone in assessing primary studies of cancer screening in Japan which served as a stimulus for the development of cancer screening guidelines...
January 5, 2018: Japanese Journal of Clinical Oncology
https://www.readbyqxmd.com/read/29313389/multi-target-stool-dna-test-in-the-surveillance-of-inflammatory-bowel-disease-a-cross-sectional-cohort-study
#12
Pasquale Klepp, John B Kisiel, Milada Cvancarova Småstuen, Arne Røseth, Solveig N Andersen, Morten H Vatn, David A Ahlquist, Bjørn A Moum, Stephan Brackmann
BACKGROUND AND AIM: Colonoscopic surveillance is recommended in patients with longstanding inflammatory bowel disease (IBD) as they are at increased risk of colorectal cancer (CRC). Non-invasive surveillance may improve compliance and access. Multi-target stool DNA (MT-sDNA) has been validated for screening of sporadic CRC but has not been assessed in IBD. Our aim was to assess the performance of a MT-sDNA test in a real-life surveillance setting of patients with longstanding IBD. MATERIAL AND METHODS: A total of 192 IBD patients enrolled from two prospective cohorts submitted an EDTA buffered stool sample and underwent chromo- or white light colonoscopy...
January 9, 2018: Scandinavian Journal of Gastroenterology
https://www.readbyqxmd.com/read/29312533/loss-of-pacs-2-delays-regeneration-in-dss-induced-colitis-but-does-not-affect-the-apcmin-model-of-colorectal-cancer
#13
Sarah L Dombernowsky, Jeanette Schwarz, Jacob Samsøe-Petersen, Reidar Albrechtsen, Kim B Jensen, Gary Thomas, Marie Kveiborg
PACS-2 is a multifunctional sorting protein that mediates cell homeostasis. We recently identified PACS-2 in a functional genome-wide siRNA screen for novel regulators of the metalloproteinase ADAM17, the main sheddase for ligands of the ErbB receptor family. Of note, we showed that Pacs2-/- mice have significantly reduced EGFR activity and proliferative index in the intestinal epithelium. As EGFR signaling is highly mitogenic for intestinal epithelial stem cells, and plays essential roles in intestinal epithelial regeneration and tumor development, we have now examined the role of PACS-2 in these processes...
December 12, 2017: Oncotarget
https://www.readbyqxmd.com/read/29309089/evaluating-the-effectiveness-of-one-on-one-conversations-to-increase-colorectal-cancer-screening-in-a-community-based-clinical-setting
#14
Tyler J Fleming, Martha G Benitez, Miranda L Ritterman Weintraub
Context: The American Cancer Society's 80% by 2018 initiative aims to increase at-home colorectal cancer (CRC) screening. Objective: To assess the effectiveness of one-on-one conversations with patients about CRC screening on compliance with at-home fecal immunochemical tests (FITs). Setting: Federally funded health care center serving a largely minority, urban, underserved population in Vallejo, California. Methods: Patients aged 50 to 75 years were divided into 3 main intervention arms: (1) patients who received a one-on-one in-person consultation to discuss the need for CRC screening and the screening process, as well as a FIT; (2) patients who received a telephone call to discuss the need for CRC screening and the screening process before receiving a FIT in the mail; and (3) patients who were mailed a FIT with a letter explaining the importance of completing the FIT and instructions...
January 1, 2018: Journal of the American Osteopathic Association
https://www.readbyqxmd.com/read/29308944/health-literacy-levels-and-views-about-being-invited-to-a-colorectal-cancer-screening-program
#15
Johanna Wangmar, Anna Jervaeus, Kaisa Fritzell, Josefin Wångdahl, Rolf Hultcrantz, Yvonne Wengström
BACKGROUND: Sweden has not yet implemented a national screening program for colorectal cancer, but a nationwide study is ongoing; the Screening of Swedish Colons (SCREESCO). Previous research shows that the use of health care services, together with several health-related outcomes, is associated with an individual's level of health literacy. However, the relation between health literacy and participation in colorectal cancer screening has produced varying results reported within the few studies addressing this issue and therefore, further research is warranted...
January 8, 2018: Acta Oncologica
https://www.readbyqxmd.com/read/29308055/masculinity-beliefs-and-colorectal-cancer-screening-in-male-veterans
#16
Shannon M Christy, Catherine E Mosher, Susan M Rawl, David A Haggstrom
As the third most common cause of cancer death among United States men, colorectal cancer (CRC) represents a significant threat to men's health. Although adherence to CRC screening has the potential to reduce CRC mortality by approximately half, men's current rates of adherence fall below national screening objectives. In qualitative studies, men have reported forgoing screenings involving the rectum (e.g., colonoscopy) due to concern about breaching masculinity norms. However, the extent to which masculinity beliefs predict men's CRC screening adherence has yet to be examined...
October 2017: Psychology of Men & Masculinity
https://www.readbyqxmd.com/read/29306603/colon-cancer-with-rapid-growth-in-16%C3%A2-months-confirmed-by-computed-tomographic-colonography
#17
Masaki Matsuoka, Norihito Shimizu, Koichi Nagata, Hiroshi Saito
This report describes a case of rapidly growing colon cancer confirmed by computed tomographic colonography (CTC). A 75-year-old woman presented at our clinic with complaints of abdominal discomfort and melena. Colorectal examination was performed via CTC. The findings were normal. Sixteen months later, she was referred to our clinic again for positive findings on a faecal immunochemical screening test. A repeat CTC was performed, which revealed a 3 cm ulcerated tumour at the ascending colon. Colonoscopy with biopsy revealed tubular adenocarcinoma...
January 3, 2018: Arab Journal of Gastroenterology: the Official Publication of the Pan-Arab Association of Gastroenterology
https://www.readbyqxmd.com/read/29304835/a-systematic-review-of-clinic-and-community-intervention-to-increase-fecal-testing-for-colorectal-cancer-in-rural-and-low-income-populations-in-the-united-states-how-what-and-when
#18
Melinda M Davis, Michele Freeman, Jackilen Shannon, Gloria D Coronado, Kurt C Stange, Jeanne-Marie Guise, Stephanie B Wheeler, David I Buckley
BACKGROUND: Interventions to improve fecal testing for colorectal cancer (CRC) exist, but are not yet routine practice. We conducted this systematic review to determine how implementation strategies and contextual factors influenced the uptake of interventions to increase Fecal Immunochemical Tests (FIT) and Fecal Occult Blood Testing (FOBT) for CRC in rural and low-income populations in the United States. METHODS: We searched Medline and the Cochrane Library from January 1998 through July 2016, and Scopus and clinicaltrials...
January 6, 2018: BMC Cancer
https://www.readbyqxmd.com/read/29304221/type-2-diabetes-and-risk-of-incident-cancers-in-china-a-prospective-study-among-0-5-million-chinese-adults
#19
Xiong-Fei Pan, Meian He, Canqing Yu, Jun Lv, Yu Guo, Zheng Bian, Ling Yang, Yiping Chen, Tangchun Wu, Zhengming Chen, An Pan, Liming Li
Using data from the China Kadoorie Biobank study, we conducted a prospective investigation on the association between type 2 diabetes mellitus (T2DM) and cancer risk in Chinese adults. A total of 508,892 participants (mean (standard deviation) age = 51.5 (10.7) years) without prior cancer diagnosis at baseline (2004-2008) were included. We documented 17,463 incident cancer cases during follow-up until December 31, 2013. Participants with T2DM had increased risks of total and certain site-specific cancers, and the hazard ratio (HR) was 1...
January 3, 2018: American Journal of Epidemiology
https://www.readbyqxmd.com/read/29303099/-cancer-detection-following-unprovoked-vte-case-history-and-physical-examination-are-still-of-foremost-importance
#20
G J Geersing
The relation between cancer and thrombosis is well known. In fact, the presence of an occult malignancy in patients with unprovoked venous thromboembolism (VTE) is named after a famous 19th century French physician; it is called Trousseau's sign. In this commentary, I elaborate upon findings from a recent individual patient data meta-analysis on Trousseau's sign. This study demonstrated that extensive screening to unmask an occult malignancy in unprovoked VTE is no better than 'simple' history taking and physical examination, alongside age-specific and gender-specific national cancer screening e...
2018: Nederlands Tijdschrift Voor Geneeskunde
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