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Colorectal cancer screening

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https://www.readbyqxmd.com/read/28813112/what-do-cochrane-systematic-reviews-say-about-the-clinical-effectiveness-of-screening-and-diagnostic-tests-for-cancer
#1
André Tito Pereira Bueno, Vladimir Lisboa Capelasso, Rafael Leite Pacheco, Carolina de Oliveira Cruz Latorraca, Tiago Biachi de Castria, Daniela Vianna Pachito, Rachel Riera
CONTEXT AND OBJECTIVE: The purpose of screening tests for cancer is to detect it at an early stage in order to increase the chances of treatment. However, their unrestrained use may lead to unnecessary examinations, overdiagnosis and higher costs. It is thus necessary to evaluate their clinical effects in terms of benefits and harm. DESIGN AND SETTING: Review of Cochrane systematic reviews, carried out in the Discipline of Evidence-Based Medicine, Escola Paulista de Medicina, Universidade Federal de São Paulo...
July 2017: São Paulo Medical Journal, Revista Paulista de Medicina
https://www.readbyqxmd.com/read/28812930/increasing-colorectal-cancer-screening-at-an-urban-fqhc-using-ifobt-and-patient-navigation
#2
Richard L Martin, Madelaine Tully, Allison Kos, David Frazer, Amy Williamson, Amy Conlon, James J Enser, Noelle K LoConte
INTRODUCTION: Colorectal cancer is the second leading cause of cancer death in the United States. Black Americans suffer even higher incidence and death rates than the general population. Genetics and patient perceptions explain some of this difference, however, modifiable health care system factors such as lack of access to colon cancer screening also contribute. Partnering an academic health center with local community groups, we piloted a colorectal cancer screening program at a Federally Qualified Health Center (FQHC) serving predominately low socioeconomic status Black Americans...
September 2017: Health Promotion Practice
https://www.readbyqxmd.com/read/28812395/current-research-on-circular-rnas-associated-with-colorectal-cancer
#3
Penghui Wang, Xiaodong He
Representing a novel type of endogenous noncoding RNAs, circular RNAs (circRNAs) have recently gained much attention for their involvement in multiple biological processes. CircRNAs are ubiquitously expressed in eukaryotic cells and modulate gene expression by acting as sponges of microRNAs (miRNAs) or other proteins, such as RNA-binding proteins (RBPs). Due to their unique structure, circRNAs are more stable than linear RNAs. Expression profiles of circRNAs are associated with clinicopathological characteristics of colorectal cancer patients, such as differentiation, TNM classification and distant metastasis...
August 16, 2017: Scandinavian Journal of Gastroenterology
https://www.readbyqxmd.com/read/28812255/persisting-racial-disparities-in-colonoscopy-screening-of-persons-with-a-family-history-of-colorectal-cancer
#4
Meng-Han Tsai, Sudha Xirasagar, Piet C de Groen
With 23 and 47% higher colorectal cancer (CRC) incidence and mortality, respectively, among African Americans vs. Whites, CRC screening studies are important. Screening guidelines recommend 5-yearly colonoscopy screening of persons with a family history of CRC (first-degree relatives, FDRs), beginning at 40 years of age. For this elevated-risk group, colonoscopy screening is preferred because of the risk of more aggressive cancer that may elude early detection by other methods. African Americans with a family history of CRC are at the intersection of two elevated risk demographics, race and FDR status...
August 15, 2017: Journal of Racial and Ethnic Health Disparities
https://www.readbyqxmd.com/read/28812118/-long-term-results-of-colorectal-cancer-screening-using-sigmoidoscopy-uk-flexible-sigmoidoscopy-screening-trial-ukfsst
#5
M Ebert, S Nitschmann
No abstract text is available yet for this article.
August 15, 2017: Der Internist
https://www.readbyqxmd.com/read/28811705/colorectal-cancer-screening-an-updated-review-of-the-available-options
#6
REVIEW
Iyad A Issa, Malak Noureddine
Colorectal cancer (CRC) is a significant cause of morbidity and mortality worldwide. However, colon cancer incidence and mortality is declining over the past decade owing to adoption of effective screening programs. Nevertheless, in some parts of the world, CRC incidence and mortality remain on the rise, likely due to factors including "westernized" diet, lifestyle, and lack of health-care infrastructure and resources. Participation and adherence to different national screening programs remain obstacles limiting the achievement of screening goals...
July 28, 2017: World Journal of Gastroenterology: WJG
https://www.readbyqxmd.com/read/28811701/colorectal-cancer-in-young-adults-a-difficult-challenge
#7
EDITORIAL
Fábio Guilherme Campos
Sporadic colorectal cancer (CRC) is traditionally diagnosed after the sixth decade of life, and current recommendations for surveillance include only patients older than 50 years of age. However, an increasing incidence of CRC in patients less than 40 years of age has been reported. This occurrence has been attributed to different molecular features and low suspicion of CRC in young symptomatic individuals. When confronting young-onset CRC with older patients, issues such as biological aggressiveness, stage at diagnosis and clinical outcomes seem to differ in many aspects...
July 28, 2017: World Journal of Gastroenterology: WJG
https://www.readbyqxmd.com/read/28807841/racial-disparity-in-gastrointestinal-cancer-risk
#8
REVIEW
Hassan Ashktorab, Sonia S Kupfer, Hassan Brim, John M Carethers
Cancer from the gastrointestinal tract and its associated excretory organs will occur in over 300,000 Americans in 2017, with colorectal cancer responsible for over forty percent of that burden; there will be over 150,000 deaths from this group of cancers in the same time period. Disparities among subgroups related to these cancers' incidence and mortality exist. The epidemiology and risk factors associated with each cancer bear out differences for racial groups in the United States. Esophageal adenocarcinoma is more frequent in Non-Hispanic Whites, whereas esophageal squamous cell carcinoma with risk factors of tobacco and alcohol is more frequent among Blacks...
August 11, 2017: Gastroenterology
https://www.readbyqxmd.com/read/28806955/reducing-the-socioeconomic-gradient-in-uptake-of-the-nhs-bowel-cancer-screening-programme-using-a-simplified-supplementary-information-leaflet-a-cluster-randomised-trial
#9
Samuel G Smith, Jane Wardle, Wendy Atkin, Rosalind Raine, Lesley M McGregor, Gemma Vart, Steve Morris, Stephen W Duffy, Susan Moss, Allan Hackshaw, Stephen Halloran, Ines Kralj-Hans, Rosemary Howe, Julia Snowball, Graham Handley, Richard F Logan, Sandra Rainbow, Steve Smith, Mary Thomas, Nicholas Counsell, Christian von Wagner
BACKGROUND: Uptake of colorectal cancer screening is low in the English NHS Bowel Cancer Screening Programme (BCSP). Participation in screening is strongly associated with socioeconomic status. The aim of this study was to determine whether a supplementary leaflet providing the 'gist' of guaiac-based Faecal Occult Blood test (gFOBt) screening for colorectal cancer could reduce the socioeconomic status (SES) gradient in uptake in the English NHS BCSP. METHODS: The trial was integrated within routine BCSP operations in November 2012...
August 14, 2017: BMC Cancer
https://www.readbyqxmd.com/read/28806777/a-synthetic-sickness-screen-for-senescence-re-engagement-targets-in-mutant-cancer-backgrounds
#10
Claire J Cairney, Lauren S Godwin, Alan E Bilsland, Sharon Burns, Katrina H Stevenson, Lynn McGarry, John Revie, Jon D Moore, Ceri M Wiggins, Rebecca S Collinson, Clare Mudd, Elpida Tsonou, Mahito Sadaie, Dorothy C Bennett, Masashi Narita, Christopher J Torrance, W Nicol Keith
Senescence is a universal barrier to immortalisation and tumorigenesis. As such, interest in the use of senescence-induction in a therapeutic context has been gaining momentum in the past few years; however, senescence and immortalisation remain underserved areas for drug discovery owing to a lack of robust senescence inducing agents and an incomplete understanding of the signalling events underlying this complex process. In order to address this issue we undertook a large-scale morphological siRNA screen for inducers of senescence phenotypes in the human melanoma cell line A375P...
August 14, 2017: PLoS Genetics
https://www.readbyqxmd.com/read/28803938/organoids-as-preclinical-models-to-improve-intraperitoneal-chemotherapy-effectiveness-for-colorectal-cancer-patients-with-peritoneal-metastases-preclinical-models-to-improve-hipec
#11
P Roy, C Canet-Jourdan, M Annereau, O Zajac, M Gelli, S Broutin, L Mercier, A Paci, F Lemare, M Ducreux, D Elias, D Malka, V Boige, D Goéré, F Jaulin
BACKGROUND: Peritoneal metastases (PM), corresponding to tumor implants into the peritoneal cavity, are associated with impaired prognosis and low responsiveness to systemic chemotherapy. A new therapeutic approach has dramatically changed the prognosis of patients with PM from colorectal cancer (CRC), consisting in the association of a complete cytoreductive surgery followed by intraperitoneal chemotherapy associated to hyperthermia (HIPEC). Many drugs have been administered intraperitoneally, but no clear consensus has been approved...
August 10, 2017: International Journal of Pharmaceutics
https://www.readbyqxmd.com/read/28799428/full-spectrum-endoscopy-fuse-versus-standard-forward-viewing-endoscope-sfv-in-a-high-risk-population
#12
Søren Roepstorff, Sabah Anwar Hadi, Morten Rasmussen
OBJECTIVES: To investigate the diagnostic performance of Full Spectrum Endoscopy (FUSE) compared to a conventional standard forward-viewing endoscope (SFV). The primary outcome was adenoma detection rate (ADR) and mean adenoma detection. Secondary outcome was feasibility of FUSE opposed to SFV. MATERIALS AND METHODS: Consecutive patients participating in the Danish colorectal cancer (CRC) screening programme were prospectively included in the study (n = 205)...
August 11, 2017: Scandinavian Journal of Gastroenterology
https://www.readbyqxmd.com/read/28799068/colorectal-cancer-screening-in-asia
#13
REVIEW
Han-Mo Chiu, Wen-Feng Hsu, Li-Chun Chang, Ming-Hsiang Wu
PURPOSE OF REVIEW: Colorectal cancer (CRC) is increasing in Asia, especially in regions with higher levels of economic development. Several Asian countries have launched population CRC screening programs to combat this devastating disease because previous studies have demonstrated that either fecal occult blood test or lower gastrointestinal endoscopy can effectively reduce CRC mortality. RECENT FINDINGS: Screening includes engaging the population, testing, administering a confirmation examination, and treating screening-detected neoplasms; thus, monitoring the whole process using measurable indicators over time is of utmost importance...
August 10, 2017: Current Gastroenterology Reports
https://www.readbyqxmd.com/read/28798944/diet-alcohol-use-and-colorectal-cancer-screening-among-black-church-goers
#14
Nga T Nguyen, Elaine J Savoy, Lorraine R Reitzel, Minh-Anh H Nguyen, David W Wetter, Jacqueline Reese-Smith, Lorna H McNeill
OBJECTIVES: Interventions for colorectal cancer (CRC) prevention among black adults are needed. Connections between CRC screening non-adherence and other health risk behaviors may inform intervention development. METHODS: Associations between red meat (RM) and fruit and vegetable (FV) consumption, at-risk alcohol use, and CRC ever-screening were examined using adjusted logistic regressions among 520 church-going black adults in Houston, Texas, aged >50. RESULTS: In the final adjusted model, being younger, uninsured, eating more RM and engaging in at-risk alcohol use were associated with lower likelihood of CRC ever-screening...
March 2017: Health Behavior and Policy Review
https://www.readbyqxmd.com/read/28798920/new-device-to-implement-the-adenoma-detection-rate
#15
REVIEW
Maddalena Zippi, Wandong Hong, Pietro Crispino, Giampiero Traversa
It is well-known that colonoscopy is considered the gold standard for colon cancer prevention. Although performed by experienced endoscopists, the matter remains of polyps missed during this examination. The reasons may include the size, shape and location of the lesions. Many colorectal cancer screening programs have been proposed to increase the adenoma detection rate. The substantial difference between these methods is whether the improvement in vision, particularly the detection of irregularities of the mucosa, is inside the endoscope electronic components (magnification, wide-angle vision, narrow band imaging, flexible spectral imaging colour enhancement, i-Scan) or outside the same, by the use of specific caps (EndoCuff, EndoVision, EndoRings)...
July 16, 2017: World Journal of Clinical Cases
https://www.readbyqxmd.com/read/28798748/role-of-type-i-and-ii-interferons-in-colorectal-cancer-and-melanoma
#16
REVIEW
Simone Di Franco, Alice Turdo, Matilde Todaro, Giorgio Stassi
Cancer can be considered an aberrant organ with a hierarchical composition of different cell populations. The tumor microenvironment, including the immune cells and related cytokines, is crucial during all the steps of tumor development. In particular, type I and II interferons (IFNs) are involved in a plethora of mechanisms that regulate immune responses in cancer, thus balancing immune escape versus immune surveillance. IFNs are involved in both the direct and indirect regulation of cancer cell proliferation and metastatic potential...
2017: Frontiers in Immunology
https://www.readbyqxmd.com/read/28797257/identification-of-key-lncrnas-in-colorectal-cancer-progression-based-on-associated-protein-protein-interaction-analysis
#17
Haishan Zhu, Jiajing Yu, Haifeng Zhu, Yusheng Guo, Shengjie Feng
BACKGROUND: Colorectal cancer (CRC) was one of the most commonly diagnosed malignancies. The molecular mechanisms involved in the progression of CRC remain unclear. Accumulating evidences showed that long noncoding RNAs (lncRNAs) played key roles in tumorigenesis, cancer progression, and metastasis. Therefore, we aimed to explore the roles of lncRNAs in the progression of CRC. METHODS: In this study, we aimed to identify differentially expressed lncRNAs and messenger RNAs (mRNAs) in CRC by analyzing a cohort of previously published datasets: GSE64857...
August 10, 2017: World Journal of Surgical Oncology
https://www.readbyqxmd.com/read/28796231/impact-of-fecal-hb-levels-on-advanced-neoplasia-detection-and-the-diagnostic-miss-rate-for-colorectal-cancer-screening-in-high-risk-vs-average-risk-subjects-a-multi-center-study
#18
Satimai Aniwan, Thawee Ratanachu-Ek, Supot Pongprasobchai, Julajak Limsrivilai, Ong-Ard Praisontarangkul, Pises Pisespongsa, Pisaln Mairiang, Apichat Sangchan, Jaksin Sottisuporn, Naruemon Wisedopas, Pinit Kullavanijaya, Rungsun Rerknimitr
OBJECTIVES: The Asia-Pacific Colorectal Screening (APCS) scoring system was developed to identify high-risk subjects for advanced neoplasia. However, the appropriate fecal immunochemical test (FIT) cutoff for high-risk population may be different from that of average-risk population. We aimed to evaluate the FIT performance at different cutoffs in high-risk subjects undergoing colorectal cancer (CRC) screening. METHODS: We prospectively enrolled asymptomatic subjects aged 50-75 years...
August 10, 2017: Clinical and Translational Gastroenterology
https://www.readbyqxmd.com/read/28796056/examining-the-association-between-possessing-a-regular-source-of-healthcare-and-adherence-with-cancer-screenings-among-haitian-households-in-little-haiti-miami-dade-county-florida
#19
Hauchie Pang, Mariel Cataldi, Emmanuelle Allseits, Melissa Ward-Peterson, Pura Rodríguez de la Vega, Grettel Castro, Juan Manuel Acuña
Immigrant minorities regularly experience higher incidence and mortality rates of cancer. Frequently, a variety of social determinants create obstacles for those individuals to get the screenings they need. This is especially true for Haitian immigrants, a particularly vulnerable immigrant population in South Florida, who have been identified as having low cancer screening rates. While Haitian immigrants have some of the lowest cancer screening rates in the country, there is little existing literature that addresses barriers to cancer screenings among the population of Little Haiti in Miami-Dade County, Florida...
August 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28792134/serum-cea-and-ca-19-9-levels-are-associated-with-the-presence-and-severity-of-colorectal-neoplasia
#20
Nam Hee Kim, Mi Yeon Lee, Jung Ho Park, Dong Il Park, Chong Il Sohn, Kyuyong Choi, Yoon Suk Jung
PURPOSE: Limited data are available regarding the association between circulating serum carcinoembryonic antigen (CEA) or carbohydrate antigen 19-9 (CA 19-9) concentrations and colorectal adenoma. We aimed to investigate whether elevated serum CEA and CA 19-9 levels are correlated with the presence of colorectal neoplasia (CRN) and whether the levels of these antigens vary according to CRN severity. MATERIALS AND METHODS: A cross-sectional study was performed on asymptomatic subjects who underwent colonoscopy between 2010 and 2014 as part of a comprehensive health screening program in Korea...
September 2017: Yonsei Medical Journal
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