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Colorectal cancer screening

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https://www.readbyqxmd.com/read/28214250/colorectal-cancer-screening-adherence-in-selected-disabilities-over-10-years
#1
Chelsea B Deroche, Suzanne W McDermott, Joshua R Mann, James W Hardin
INTRODUCTION: Colorectal cancer (CRC) is the second leading cause of cancer mortality in the U.S.; however, if the population aged 50 years or older received routine screening, approximately 60% of these deaths could be eliminated. This study investigates whether adults, aged 50-75 years, with one of three disabilities (blind/low vision [BLV], intellectual disability [ID], spinal cord injury [SCI]) receive CRC screening at rates equivalent to adults without the three disabilities, by accounting for combinations of recommended CRC screenings during a 10-year period (colonoscopy, sigmoidoscopy, fecal occult blood test)...
February 14, 2017: American Journal of Preventive Medicine
https://www.readbyqxmd.com/read/28210537/multilevel-predictors-of-colorectal-cancer-testing-modality-among-publicly-and-privately-insured-people-turning-50
#2
Stephanie B Wheeler, Tzy-Mey Kuo, Anne Marie Meyer, Christa E Martens, Kristen M Hassmiller Lich, Florence K L Tangka, Lisa C Richardson, Ingrid J Hall, Judith Lee Smith, Maria E Mayorga, Paul Brown, Trisha M Crutchfield, Michael P Pignone
Understanding multilevel predictors of colorectal cancer (CRC) screening test modality can help inform screening program design and implementation. We used North Carolina Medicare, Medicaid, and private, commercially available, health plan insurance claims data from 2003 to 2008 to ascertain CRC test modality among people who received CRC screening around their 50th birthday, when guidelines recommend that screening should commence for normal risk individuals. We ascertained receipt of colonoscopy, fecal occult blood test (FOBT) and fecal immunochemical test (FIT) from billing codes...
June 2017: Preventive Medicine Reports
https://www.readbyqxmd.com/read/28210082/multitarget-stool-dna-tests-increases-colorectal-cancer-screening-among-previously-noncompliant-medicare-patients
#3
Mark Prince, Lynn Lester, Rupal Chiniwala, Barry Berger
AIM: To determine the uptake of noninvasive multitarget stool DNA (mt-sDNA) in a cohort of colorectal cancer (CRC) screening non-compliant average-risk Medicare patients. METHODS: This cross sectional primary care office-based study examined mt-sDNA uptake in routine clinical practice among 393 colorectal cancer screening non-compliant Medicare patients ages 50-85 ordered by 77 physicians in a multispecialty group practice (USMD Physician Services, Dallas, TX) from October, 2014-September, 2015...
January 21, 2017: World Journal of Gastroenterology: WJG
https://www.readbyqxmd.com/read/28209100/first-results-of-the-flemish-colorectal-cancer-screening-program%C3%A2-start-up-period-late-2013
#4
S Hoeck, S Pringels, E Kellen, K Van Herck, P Martens, E Van Limbergen, J Francart, G Francart
BACKGROUND AND AIMS: Investigation of the first participation rate and follow-up results of the Flemish colorectal cancer screening program. PATIENTS AND METHODS: In 2013 five age cohorts with an even age between 66 and 74 year old (n=243 335) were invited by mail to return a completed iFOBT. Participants who tested positive (≥75ng/ml) were referred to a follow-up colonoscopy. RESULTS: Participation rate was 48.4% (n=117 774). Overall positivity rate was 10...
September 2016: Acta Gastro-enterologica Belgica
https://www.readbyqxmd.com/read/28206963/circulating-mic-1-gdf15-is-a-complementary-screening-biomarker-with-cea-and-correlates-with-liver-metastasis-and-poor-survival-in-colorectal-cancer
#5
Xiaobing Wang, Zhaogang Yang, Haimei Tian, Yanfen Li, Mo Li, Wenya Zhao, Chao Zhang, Teng Wang, Jing Liu, Aili Zhang, Di Shen, Cuining Zheng, Jun Qi, Dan Zhao, Junfeng Shi, Liliang Jin, Jianyu Rao, Wei Zhang
Macrophage inhibitory cytokine 1 (MIC-1/GDF15) has been characterized as a candidate biomarker for colorectal cancer (CRC) recently. However, the role of serum MIC-1 in screening patients with early stage CRC and monitoring therapeutic response have not been well-established, particularly in the combination with CEA for the screening and the prejudgment of occurrence with liver metastasis. In this study, we performed a retrospective blinded evaluation of 987 serum samples from 473 individuals with CRC, 25 with adenomatous polyps, and 489 healthy individuals using ELISA or immunoassay...
February 11, 2017: Oncotarget
https://www.readbyqxmd.com/read/28197803/obesity-related-parameters-and-colorectal-adenoma-development
#6
Tae Jun Kim, Jee Eun Kim, Yoon-Ho Choi, Sung Noh Hong, Young-Ho Kim, Dong Kyung Chang, Poong-Lyul Rhee, Min-Ji Kim, Sin-Ho Jung, Hee Jung Son
BACKGROUND: Obesity increases the risk of colorectal adenoma and colorectal cancer. However, the obesity-related parameters that are best for assessing the risk of colorectal adenoma development remain unclear. We analyzed the parameters that may best describe the association between obesity and colorectal adenoma development. METHODS: In this retrospective cohort study, 3405 individuals underwent screening colonoscopy during routine health examinations. We measured body mass index; waist circumference; and metabolic parameters such as high-density lipoprotein-cholesterol, glucose, triglyceride, and systolic blood pressure...
February 14, 2017: Journal of Gastroenterology
https://www.readbyqxmd.com/read/28197619/evaluating-a-modular-decision-support-application-for-colorectal-cancer-screening
#7
Laura G Militello, Julie B Diiulio, Morgan R Borders, Christen E Sushereba, Jason J Saleem, Donald Haverkamp, Thomas F Imperiale
BACKGROUND: There is a need for health information technology evaluation that goes beyond randomized controlled trials to include consideration of usability, cognition, feedback from representative users, and impact on efficiency, data quality, and clinical workflow. This article presents an evaluation illustrating one approach to this need using the Decision-Centered Design framework. OBJECTIVE: To evaluate, through a Decision-Centered Design framework, the ability of the Screening and Surveillance App to support primary care clinicians in tracking and managing colorectal cancer testing...
February 15, 2017: Applied Clinical Informatics
https://www.readbyqxmd.com/read/28196067/body-weight-trajectories-and-risk-of-oesophageal-and-gastric-cardia-adenocarcinomas-a-pooled-analysis-of-nih-aarp-and-plco-studies
#8
Jessica L Petrick, Scott P Kelly, Linda M Liao, Neal D Freedman, Barry I Graubard, Michael B Cook
BACKGROUND: Elevated body mass index (BMI, kg m(-2)) has been consistently associated with oesophageal adenocarcinoma (EA) and gastric cardia adenocarcinoma (GCA) incidence. However, effects of adiposity over the life course in relation to EA/GCA have not been thoroughly explored. METHODS: We pooled two prospective cohort studies: NIH-AARP Diet and Health Study and Prostate, Lung, Colorectal, and Ovarian (PLCO) Cancer Screening Trial, with data on 409 796 individuals (633 EA, 415 GCA)...
February 14, 2017: British Journal of Cancer
https://www.readbyqxmd.com/read/28195508/incidence-of-interval-cancers-in-faecal-immunochemical-test-colorectal-screening-programmes-in-italy
#9
Paolo Giorgi Rossi, Elisa Carretta, Lucia Mangone, Susanna Baracco, Diego Serraino, Manuel Zorzi
Objective In Italy, colorectal screening programmes using the faecal immunochemical test from ages 50 to 69 every two years have been in place since 2005. We aimed to measure the incidence of interval cancers in the two years after a negative faecal immunochemical test, and compare this with the pre-screening incidence of colorectal cancer. Methods Using data on colorectal cancers diagnosed in Italy from 2000 to 2008 collected by cancer registries in areas with active screening programmes, we identified cases that occurred within 24 months of negative screening tests...
January 1, 2017: Journal of Medical Screening
https://www.readbyqxmd.com/read/28195393/use-of-multigene-panel-identifies-pathogenic-variants-in-several-crc-predisposing-genes-in-patients-previously-tested-for-lynch-syndrome
#10
Maren F Hansen, Jostein Johansen, Anna E Sylvander, Inga Bjørnevoll, Bente A Talseth-Palmer, Liss Anne S Lavik, Alexandre Xavier, Lars F Engebretsen, Rodney J Scott, Finn Drabløs, Wenche Sjursen
Many families with a high burden of colorectal cancer fulfil the clinical criteria for Lynch Syndrome. However, in about half of these families, no germline mutation in the mismatch repair genes known to be associated with this disease can be identified. The aim of this study was to find the genetic cause for the increased colorectal cancer risk in these unsolved cases. Therefore, we designed a gene panel targeting 112 previously known or candidate colorectal cancer susceptibility genes to screen 274 patient samples for mutations...
February 14, 2017: Clinical Genetics
https://www.readbyqxmd.com/read/28195261/immunohistochemical-evaluation-of-mismatch-repair-proteins-in-colorectal-carcinoma-the-aifeg-gipad-proposal
#11
A Remo, M Fassan, G Lanza
Microsatellite instability (MSI) is a hypermutable phenotype that usually arises from either a germline mutation in components of the mismatch repair (MMR) machinery (i.e. hMLH1, MSH2, MSH6 and PMS2) in patients with Lynch syndrome (LS) or somatic hypermethylation of the hMLH1 promoter in sporadic carcinomas. In all colorectal cancers (CRC) is possible to identify the MMR deficiency through protein expression by immunoistochemistry (IHC). Recently, the predictive role of MMR deficiency in reduced chemotherapy benefit and the introduction of universal screening for Lynch syndrome suggest to include MMR testing into routine clinical practice...
September 2016: Pathologica
https://www.readbyqxmd.com/read/28195176/the-non-coding-variant-rs1800734-enhances-dclk3-expression-through-long-range-interaction-and-promotes-colorectal-cancer-progression
#12
Ning Qing Liu, Menno Ter Huurne, Luan N Nguyen, Tianran Peng, Shuang-Yin Wang, James B Studd, Onkar Joshi, Halit Ongen, Jesper B Bramsen, Jian Yan, Claus L Andersen, Jussi Taipale, Emmanouil T Dermitzakis, Richard S Houlston, Nina C Hubner, Hendrik G Stunnenberg
Genome-wide association studies have identified a great number of non-coding risk variants for colorectal cancer (CRC). To date, the majority of these variants have not been functionally studied. Identification of allele-specific transcription factor (TF) binding is of great importance to understand regulatory consequences of such variants. A recently developed proteome-wide analysis of disease-associated SNPs (PWAS) enables identification of TF-DNA interactions in an unbiased manner. Here we perform a large-scale PWAS study to comprehensively characterize TF-binding landscape that is associated with CRC, which identifies 731 allele-specific TF binding at 116 CRC risk loci...
February 14, 2017: Nature Communications
https://www.readbyqxmd.com/read/28194568/t1-colon-cancer-in-the-era-of-screening-risk-factors-and-treatment
#13
F Bianco, S De Franciscis, A Belli, A Falato, R Fusco, D F Altomare, A Amato, C R Asteria, A Avallone, G A Binda, L Boccia, P Buzzo, M Carvello, C Coco, P Delrio, P De Nardi, M Di Lena, A Failla, F La Torre, M La Torre, M Lemma, P Luffarelli, G Manca, I Maretto, F Marino, A Muratore, A Pascariello, S Pucciarelli, D Rega, V Ripetti, G Rizzo, A Serventi, A Spinelli, F Tatangelo, E D L Urso, G M Romano
BACKGROUND: The aim of this study was to identify risk factors for lymph node positivity in T1 colon cancer and to carry out a surgical quality assurance audit. METHODS: The sample consisted of consecutive patients treated for early-stage colon lesions in 15 colorectal referral centres between 2011 and 2014. The study investigated 38 factors grouped into four categories: demographic information, preoperative data, indications for surgery and post-operative data...
February 13, 2017: Techniques in Coloproctology
https://www.readbyqxmd.com/read/28193070/toward-liquid-biopsy-determination-of-the-humoral-immune-response-in-cancer-patients-using-halotag-fusion-protein-modified-electrochemical-bioplatforms
#14
María Garranzo-Asensio, Ana Guzman-Aranguez, Carmen Povés, María Jesús Fernández-Aceñero, Rebeca M Torrente-Rodríguez, Víctor Ruiz-Valdepeñas Montiel, Gemma Domínguez, Luis San Frutos, Nuria Rodríguez, Mayte Villalba, José M Pingarrón, Susana Campuzano, Rodrigo Barderas
Autoantibodies raised against tumor-associated antigens have shown high promise as clinical biomarkers for reliable diagnosis, prognosis, and therapy monitoring of cancer. An electrochemical disposable biosensor for the specific and sensitive determination of p53-specific autoantibodies has been developed for the first time in this work. This biosensor involves the use of magnetic microcarriers (MBs) modified with covalently immobilized HaloTag fusion p53 protein as solid supports for the selective capture of specific autoantibodies...
December 20, 2016: Analytical Chemistry
https://www.readbyqxmd.com/read/28191946/in-search-of-novel-cdk8-inhibitors-by-virtual-screening
#15
Malika Kumarasiri, Theodosia Teo, Mingfeng Yu, Stephen Philip, Sunita K C Basnet, Hugo Albrecht, Matthew J Sykes, Peng Wang, Shudong Wang
Aberrant activity of cyclin-dependent kinase (CDK) 8 is implicated in various cancers. While CDK8-targeting anticancer drugs are highly sought-after, no CDK8 inhibitor has yet reached clinical trials. Herein a large library of drug-like molecules was computationally screened using two complementary cascades to identify potential CDK8 inhibitors. Thirty-three hits were identified to inhibit CDK8 and seven of them were active against colorectal cancer cell lines. Finally, the primary target was confirmed using three promising hits...
February 16, 2017: Journal of Chemical Information and Modeling
https://www.readbyqxmd.com/read/28190597/costs-of-colorectal-cancer-screening-provision-in-cdc-s-colorectal-cancer-control-program-comparisons-of-colonoscopy-and-fobt-fit-based-screening
#16
Sujha Subramanian, Florence K L Tangka, Sonja Hoover, Janet Royalty, Amy DeGroff, Djenaba Joseph
We assess annual costs of screening provision activities implemented by 23 of the Centers for Disease Control and Prevention's Colorectal Cancer Control Program (CRCCP) grantees and report differences in costs between colonoscopy and FOBT/FIT-based screening programs. We analysed annual cost data for the first three year of the CRCCP (July 2009-June 2011) for each screening provision activity and categorized them into clinical and non-clinical screening provision activities. The largest cost components for both colonoscopy and FOBT/FIT-based programs were screening and diagnostic services, program management, and data collection and tracking...
February 7, 2017: Evaluation and Program Planning
https://www.readbyqxmd.com/read/28188568/a-comprehensive-electronic-health-record-based-patient-navigation-module-including-technology-driven-colorectal-cancer-outreach-and-education
#17
Sunny Ajeesh, Rustveld Luis
The purpose of this concept paper is to propose an innovative multifaceted patient navigation module embedded in the Electronic Health Record (EHR) to address barriers to efficient and effective colorectal cancer (CRC) care. The EHR-based CRC patient navigation module will include several patient navigation features: (1) CRC screening registry; (2) patient navigation data, including CRC screening data, outcomes of patient navigation including navigation status (CRC screening referrals, fecal occult blood test (FOBT) completed, colonoscopy scheduled and completed, cancelations, reschedules, and no-shows); (3) CRC counseling aid; and 4) Web-based CRC education application including interactive features such as a standardized colonoscopy preparation guide, modifiable CRC risk factors, and links to existing resources...
February 10, 2017: Journal of Cancer Education: the Official Journal of the American Association for Cancer Education
https://www.readbyqxmd.com/read/28186354/feasibility-of-cyfra-21-1-as-a-serum-biomarker-for-the-detection-of-colorectal-adenoma-and-advanced-colorectal-adenoma-in-people-over-the-age-of-45
#18
Do Hyoung Lim, Jai Hyuen Lee, Jong Wan Kim
BACKGROUND: Colon adenoma (CA) is a premalignant lesion of colorectal cancer, and its early removal is closely associated with more prolonged survival in the general population. In this study, we aimed to evaluate the relationship between diverse biologic markers and a newly diagnosed CA and to predict the clinical possibility of cytokeratin-19 soluble in serum fragment (CYFRA 21-1) as a screening tool in asymptomatic adults aged over 45 years. METHODS: Four hundred and seventy-nine patients with a histologically confirmed CA or benign colon polyp (BCP), 76 patients with only benign colorectal diseases and 223 negative controls with no CA or BCP detected on colonofibroscopy were investigated...
February 10, 2017: Journal of Clinical Laboratory Analysis
https://www.readbyqxmd.com/read/28184026/identification-of-tmem208-and-pqlc2-as-reference-genes-for-normalizing-mrna-expression-in-colorectal-cancer-treated-with-aspirin
#19
Yuanyuan Zhu, Chao Yang, Mingjiao Weng, Yan Zhang, Chunhui Yang, Yinji Jin, Weiwei Yang, Yan He, Yiqi Wu, Yuhua Zhang, Guangyu Wang, Riju James RajkumarEzakiel Redpath, Lei Zhang, Xiaoming Jin, Ying Liu, Yuchun Sun, Ning Ning, Yu Qiao, Fengmin Zhang, Zhiwei Li, Tianzhen Wang, Yanqiao Zhang, Xiaobo Li
Numerous evidences indicate that aspirin usage causes a significant reduction in colorectal cancer. However, the molecular mechanisms about aspirin preventing colon cancer are largely unknown. Quantitative reverse transcription polymerase chain reaction (qRT-PCR) is a most frequently used method to identify the target molecules regulated by certain compound. However, this method needs stable internal reference genes to analyze the expression change of the targets. In this study, the transcriptional stabilities of several traditional reference genes were evaluated in colon cancer cells treated with aspirin, and also, the suitable internal reference genes were screened by using a microarray and were further identified by using the geNorm and NormFinder softwares, and then were validated in more cell lines and xenografts...
February 8, 2017: Oncotarget
https://www.readbyqxmd.com/read/28182647/performance-analysis-of-a-machine-learning-flagging-system-used-to-identify-a-group-of-individuals-at-a-high-risk-for-colorectal-cancer
#20
Yaron Kinar, Pinchas Akiva, Eran Choman, Revital Kariv, Varda Shalev, Bernard Levin, Steven A Narod, Ran Goshen
Individuals with colorectal cancer (CRC) have a tendency to intestinal bleeding which may result in mild to severe iron deficiency anemia, but for many colon cancer patients hematological abnormalities are subtle. The fecal occult blood test (FOBT) is used as a pre-screening test whereby those with a positive FOBT are referred to colonscopy. We sought to determine if information contained in the complete blood count (CBC) report coud be processed automatically and used to predict the presence of occult colorectal cancer (CRC) in the setting of a large health services plan...
2017: PloS One
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