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https://www.readbyqxmd.com/read/28224857/women-of-the-world-are-saying-this-is-wrong
#1
Genevieve Edwards
As part of the Marie Stopes UK team, I believe that every woman has the right to choose whether and when to have children. But for millions of women worldwide, that right has just been snatched away.
February 22, 2017: Nursing Standard
https://www.readbyqxmd.com/read/28195976/self-reported-measures-of-strength-and-sport-specific-skills-distinguish-ranking-in-an-international-online-fitness-competition
#2
Paul R Serafini, Yuri Feito, Gerald T Mangine
To determine if self-reported performance measures could distinguish ranking during the 2016 CrossFit Open, data from three thousand male (n=1500; 27.2±8.4 y; 85.2±7.9 kg; 177.0±6.5 cm) and female (n=1500, 28.7±4.9 y; 63.7±5.8 kg; 163.7±6.6 cm) competitors was used for this study. Competitors were split by gender and grouped into quintiles (Q1-Q5) based upon their final ranking. Quintiles were compared for one-repetition maximum (1RM) squat, deadlift, clean and jerk (CJ), snatch, 400-m sprint, 5,000-m run, and benchmark workouts (Fran, Helen, Grace, Filthy-50, and Fight-gone-bad)...
February 8, 2017: Journal of Strength and Conditioning Research
https://www.readbyqxmd.com/read/28195975/the-high-bar-and-low-bar-back-squats-a-biomechanical-analysis
#3
Daniel J Glassbrook, Scott R Brown, Eric R Helms, J Scott Duncan, Adam G Storey
No prior study has compared the joint angle and ground reaction force (Fv) differences between the high-bar back-squat (HBBS) and low-bar back-squat (LBBS) above 90% 1RM. Six male powerlifters (height: 179.2 ± 7.8 cm; bodyweight: 87.1 ± 8.0 kg; age: 27.3 ± 4.2 years) of international level, six male Olympic weightlifters (height: 176.7 ± 7.7 cm; bodyweight: 83.1 ± 13 kg; age: 25.3 ± 3.1 years) of national level, and six recreationally trained male athletes (height: 181.9 ± 8.7 cm; bodyweight: 87.9 ± 15...
February 8, 2017: Journal of Strength and Conditioning Research
https://www.readbyqxmd.com/read/28154333/structural-and-biochemical-analyses-on-the-rna-dependent-rna-polymerase-of-influenza-virus-for-development-of-novel-anti-influenza-agents
#4
Dai Hatakeyama
 The PA, PB1, and PB2 subunits, components of the RNA-dependent RNA polymerase of influenza A virus, and the nucleoprotein (NP) interact with the genomic RNA of influenza viruses and form ribonucleoproteins. Especially, the PB2 subunit binds to the host RNA cap [7-methylguanosine triphosphate (m(7)GTP)] and supports the endonuclease activity of PA to "snatch" the cap from host pre-mRNAs. In this study, we describe a novel Val/Arg/Gly (VRG) site in the PB2 cap-binding domain, which is necessary for interaction with acetyl-CoA found in eukaryotic histone acetyltransferases (HATs)...
2017: Yakugaku Zasshi: Journal of the Pharmaceutical Society of Japan
https://www.readbyqxmd.com/read/28122973/role-of-the-pb2-627-domain-in-influenza-a-virus-polymerase-function
#5
Benjamin E Nilsson, Aartjan J W Te Velthuis, Ervin Fodor
The RNA genome of influenza A viruses is transcribed and replicated by the viral RNA-dependent RNA polymerase, composed of the subunits PA, PB1, and PB2. High-resolution structural data revealed that the polymerase assembles into a central polymerase core and several auxiliary highly flexible, protruding domains. The auxiliary PB2 cap-binding and the PA endonuclease domains are both involved in cap snatching, but the role of the auxiliary PB2 627 domain, implicated in host range restriction of influenza A viruses, is still poorly understood...
April 1, 2017: Journal of Virology
https://www.readbyqxmd.com/read/28115197/structural-insights-into-rna-synthesis-by-the-influenza-virus-transcription-replication-machine
#6
REVIEW
Alexander Pflug, Maria Lukarska, Patricia Resa-Infante, Stefan Reich, Stephen Cusack
Influenza virus is a segmented, negative strand RNA virus with each genome segment being packaged in a distinct ribonucleoprotein particle (RNP). The RNP consists of the heterotrimeric viral RNA-dependent RNA polymerase bound to the conserved 5' and 3' ends of the genome segment (the viral promoter) with the rest of the viral RNA (vRNA) being covered by multiple copies of nucleoprotein. This review focusses on the new insights that recent crystal structures have given into the detailed molecular mechanisms by which the polymerase performs both transcription and replication of the vRNA genome...
January 20, 2017: Virus Research
https://www.readbyqxmd.com/read/28112978/calling-texting-and-searching-information-while-riding-a-motorcycle-a-study-of-university-students-in-vietnam
#7
Long T Truong, Chris De Gruyter, Hang T T Nguyen
OBJECTIVE: To investigate the prevalence of calling, texting, and searching information while riding a motorcycle among university students and the influences of sociodemographic characteristics, social norms, and risk perceptions on these behaviours. METHODS: Students at two university campuses in Hanoi and Ho Chi Minh City, the two largest cities of Vietnam, were invited to participate in an anonymous online survey. Data collection was conducted during March and May 2016...
January 23, 2017: Traffic Injury Prevention
https://www.readbyqxmd.com/read/28030531/does-focus-of-attention-improve-snatch-lift-kinematics
#8
Kyle S Schutts, Will Wu, Anthony Vidal, Jamie Hiegel, James Becker
Recent motor control literature has demonstrated that using verbal instructions to direct a performer's attention externally (i.e. toward the movement outcome) enhances motor skill performance. The purpose of this study was to investigate how an athlete's focus of attention impacts kinematic performance of the snatch. Using a counterbalanced within-participant design, 12 competitively trained athletes (8 male, 4 female) performed 2 instructional blocks of 3 snatch repetitions at 80% of their most recent training 1RM...
December 24, 2016: Journal of Strength and Conditioning Research
https://www.readbyqxmd.com/read/27994826/crossfit-%C3%A2-instructor-demographics-and-practice-trends
#9
Gregory R Waryasz, Vladimir Suric, Alan H Daniels, Joseph A Gil, Craig P Eberson
CrossFit(®) is an increasingly popular exercise modality that uses high intensity power training. The literature to date regarding CrossFit(®) has focused on its benefits to VO2 Max, body composition and the motivational variables of participants of CrossFit(®). A computerized survey was distributed to CrossFit(®) instructors using Survey Monkey(®) (Palo Alto, CA, USA). One hundred and ninety-three CrossFit(®) instructors responded to the survey. Of these 86.6% (155/179) reported being a certified CrossFit(®) instructor with 26...
November 17, 2016: Orthopedic Reviews
https://www.readbyqxmd.com/read/27820725/training-strategies-to-improve-muscle-power-is-olympic-style-weightlifting-relevant
#10
Christian Helland, Eirik Hole, Erik Iversen, Monica Charlotte Olsson, Olivier Seynnes, Paul Andre Solberg, Gøran Paulsen
INTRODUCTION: This efficacy study investigated the effects of 1) Olympic-style weightlifting (OWL), 2) motorized strength and power training (MSPT), and 3) free weight strength and power training (FSPT) on muscle power. METHODS: Thirty-nine young athletes (20 ± 3 yr; ice hockey, volleyball, and badminton) were randomized into the three training groups. All groups participated in two to three sessions per week for 8 wk. The MSPT and FSPT groups trained using squats (two legs and single leg) with high force and high power, whereas the OWL group trained using clean and snatch exercises...
April 2017: Medicine and Science in Sports and Exercise
https://www.readbyqxmd.com/read/27771390/activities-of-jnj63623872-and-oseltamivir-against-influenza-a-h1n1pdm-and-h3n2-virus-infections-in-mice
#11
Donald F Smee, Dale L Barnard, Steven M Jones
JNJ63623872 (formerly known as VX-787) is an inhibitor of influenza A virus polymerases through interaction with the viral PB2 subunit. This interaction blocks the cap-snatching activity of the virus that is essential for virus replication. Previously published work has documented antiviral activity of JNJ63623872 in cell culture and mouse infection studies. In this report, we extend the in vivo observations by comparing the efficacies of JNJ63623872 and oseltamivir in mice infected with influenza A/California/04/2009 (H1N1pdm) and A/Victoria/3/75 (H3N2) viruses...
October 19, 2016: Antiviral Research
https://www.readbyqxmd.com/read/27601779/hang-cleans-and-hang-snatches-produce-similar-improvements-in-female-collegiate-athletes
#12
J L Ayers, M DeBeliso, T G Sevene, K J Adams
Olympic weightlifting movements and their variations are believed to be among the most effective ways to improve power, strength, and speed in athletes. This study investigated the effects of two Olympic weightlifting variations (hang cleans and hang snatches), on power (vertical jump height), strength (1RM back squat), and speed (40-yard sprint) in female collegiate athletes. 23 NCAA Division I female athletes were randomly assigned to either a hang clean group or hang snatch group. Athletes participated in two workout sessions a week for six weeks, performing either hang cleans or hang snatches for five sets of three repetitions with a load of 80-85% 1RM, concurrent with their existing, season-specific, resistance training program...
September 2016: Biology of Sport
https://www.readbyqxmd.com/read/27552211/enhancing-digital-video-analysis-of-bar-kinematics-in-weightlifting-a-case-study
#13
Torstein E Dæhlin, Tron Krosshaug, Loren Z F Chiu
Weightlifting technique can be objectively assessed from two-dimensional video recordings. Despite its importance, participants' bar trajectories in research involving the snatch or clean exercises are often not reported, potentially due to the time required to digitize video. The purpose of this investigation was to evaluate the use of an LED-based marker, digital video and open source software to automatically track the bar end during weightlifting exercises. A former national-level weightlifter was recorded with a digital video camera performing the snatch, clean and jerk, and squat exercises...
August 19, 2016: Journal of Strength and Conditioning Research
https://www.readbyqxmd.com/read/27537412/can-cold-water-immersion-enhance-recovery-in-elite-olympic-weightlifters-an-individualized-perspective
#14
Jan Schimpchen, Maximilian Wagner, Alexander Ferrauti, Michael Kellmann, Mark Pfeiffer, Tim Meyer
We investigated whether cold water immersion following intensive training sessions can enhance recovery in elite Olympic weightlifters, taking into account each athlete's individual response pattern. The entire German male Olympic weightlifting national team participated in the study (n=7), ensuring collection of data from elite athletes only. Using a randomized cross-over design, the athletes went through two high intensity training microcycles consisting of five training sessions that were either followed by a cold water immersion or passive recovery...
August 16, 2016: Journal of Strength and Conditioning Research
https://www.readbyqxmd.com/read/27457913/neuromuscular-responses-to-short-term-resistance-training-with-traditional-and-daily-undulating-periodization-in-adolescent-elite-judoka
#15
RANDOMIZED CONTROLLED TRIAL
Boris Ullrich, Thiemo Pelzer, Sergio Oliveira, Mark Pfeiffer
Ullrich, B, Pelzer, T, Oliveira, S, and Pfeiffer, M. Neuromuscular responses to short-term resistance training with traditional and daily undulating periodization in adolescent elite judoka. J Strength Cond Res 30(8): 2083-2099, 2016-The influence of different periodization models on neuromuscular outcomes after short-term strength training periods has not been examined in adolescent athletes. Eleven elite judoka (age: 14.8 ± 0.6 years, height: 163.2 ± 7.5 cm, body mass: 57.3 ± 11.1 kg, 5 boys/6 girls, and strength training experience: 2...
August 2016: Journal of Strength and Conditioning Research
https://www.readbyqxmd.com/read/27451344/jnj872-inhibits-influenza-a-virus-replication-without-altering-cellular-antiviral-responses
#16
Yu Fu, Lana Gaelings, Sandra Söderholm, Sergei Belanov, Jatin Nandania, Tuula A Nyman, Sampsa Matikainen, Simon Anders, Vidya Velagapudi, Denis E Kainov
JNJ-63623872 (formally known as VX-787; referred to here as JNJ872) is an orally bioavailable compound, which is in phase II clinical trials for the treatment of influenza A virus (IAV) infections. Here we show that JNJ872 inhibits at nanomolar concentrations the transcription of viral RNA in IAV-infected human macrophages by targeting a highly conserved site on the cap-snatching domain of influenza polymerase basic 2 protein (PB2). Furthermore, even lower concentrations of JNJ872 protected macrophages from IAV-mediated death when given in combination with 100 nM gemcitabine, which also attenuated transcription and replication of viral RNA...
September 2016: Antiviral Research
https://www.readbyqxmd.com/read/27445850/two-consecutive-days-of-crossfit-training-affects-pro-and-anti-inflammatory-cytokines-and-osteoprotegerin-without-impairments-in-muscle-power
#17
Ramires A Tibana, Leonardo M de Almeida, Nuno M Frade de Sousa, Dahan da Cunha Nascimento, Ivo V de Sousa Neto, Jeeser A de Almeida, Vinicius C de Souza, Maria de Fátima T P L Lopes, Otávio de Tolêdo Nobrega, Denis C L Vieira, James W Navalta, Jonato Prestes
The aim of this study was to investigate the effects of two consecutive Crossfit® training sessions (24 h apart) designed to enhance work-capacity that involved both cardiovascular and muscular exercises on cytokines, muscle power, blood lactate and glucose. Nine male members of the CrossFit® community (age 26.7 ± 6.6 years; body mass 78.8 ± 13.2 kg; body fat 13.5 ± 6.2%; training experience 2.5 ± 1.2 years) completed two experimental protocols (24 h apart): (1) strength and power exercises, (2) gymnastic movements, and (3) metabolic conditioning as follows: 10 min of as many rounds as possible (AMRAP) of 30 double-unders and 15 power snatches (34 kg)...
2016: Frontiers in Physiology
https://www.readbyqxmd.com/read/27408480/examination-of-a-lumbar-spine-biomechanical-model-for-assessing-axial-compression-shear-and-bending-moment-using-selected-olympic-lifts
#18
Moataz Eltoukhy, Francesco Travascio, Shihab Asfour, Shady Elmasry, Hector Heredia-Vargas, Joseph Signorile
BACKGROUND/AIMS: Loading during concurrent bending and compression associated with deadlift, hang clean and hang snatch lifts carries the potential for injury to the intervertebral discs, muscles and ligaments. This study examined the capacity of a newly developed spinal model to compute shear and compressive forces, and bending moments in lumbar spine for each lift. METHODS: Five male subjects participated in the study. The spine was modeled as a chain of rigid bodies (vertebrae) connected via the intervertebral discs...
September 2016: Journal of Orthopaedics
https://www.readbyqxmd.com/read/27385851/substance-use-and-criminality-among-juveniles-under-enquiry-in-new-delhi
#19
Shridhar Sharma, Gautam Sharma, Bristi Barkataki
BACKGROUND: There is an intimate relationship between drugs and criminal behavior. The drug-violence relationship is further complicated by intoxicating doses and/or withdrawal effects of specific drugs. Understanding this relationship is important for both healthcare workers and policy makers. MATERIALS AND METHODS: The study was conducted in Prayas observation home for boys, a short stay home for juveniles-under-enquiry in New Delhi. The present study aims to correlate substance use and criminal behavior by investigating the sociodemographic characteristics and the current trend of substance use among juveniles in New Delhi...
April 2016: Indian Journal of Psychiatry
https://www.readbyqxmd.com/read/27377998/supramolecular-guest-relay-using-host-protein-nanocavities-an-application-of-host-induced-guest-protonation
#20
Falguni Chandra, Kaushik Pal, Sushil Lathwal, Apurba L Koner
Small drug molecules and other important metabolites are delivered via a suitable carrier protein-mediated transport through a specific receptor. The process is highly coordinated and associated with complexation induced properties of deliverable molecules. To get a molecular insight, in this report, we tried to mimic the delivery process to know how the carrier protein relocates the drug molecule from the macrocyclic host cavity to its binding pocket and how the electronic and the chemical properties of the guest get altered...
August 16, 2016: Molecular BioSystems
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