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Protein AND weight loss

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https://www.readbyqxmd.com/read/29443370/beneficial-effects-of-high-density-lipoproteins-on-acquired-von-willebrand-syndrome-in-aortic-valve-stenosis
#1
C Gebhard, F Maafi, B E Stähli, A Bonnefoy, C E Gebhard, W Nachar, A Benjamim de Oliveira Moraes, M Mecteau, T Mihalache-Avram, V Lavoie, A E Kernaleguen, Y Shi, D Busseuil, M Chabot-Blanchet, L P Perrault, D Rhainds, E Rhéaume, J C Tardif
BACKGROUND: Infusions of apolipoprotein A-I (apoA-I), the major protein component of high-density lipoproteins (HDL), result in aortic valve stenosis (AVS) regression in experimental models. Severe AVS can be complicated by acquired von Willebrand syndrome, a haemorrhagic disorder associated with loss of high-molecular-weight von Willebrand factor (vWF) multimers (HMWM), the latter being a consequence of increased shear stress and enhanced vWF-cleaving protease (ADAMTS-13) activity. Although antithrombotic actions of HDL have been described, its effects on ADAMTS-13 and vWF in AVS are unknown...
February 2018: Thrombosis and Haemostasis
https://www.readbyqxmd.com/read/29433277/composition-of-black-soldier-fly-prepupae-and-systematic-approaches-for-extraction-and-fractionation-of-proteins-lipids-and-chitin
#2
Augusta Caligiani, Angela Marseglia, Giulia Leni, Stefania Baldassarre, Lara Maistrello, Arnaldo Dossena, Stefano Sforza
Black soldier fly (BSF, Hermetia illucens) constitutes an economic way to convert residual biomasses into a valuable source of biomolecules, such as proteins, lipids and chitin. The present investigation was undertaken to evaluate the feasibility of applying different extraction protocols, either chemical extractions or enzymatic assisted extraction, to recover pure fat, protein and chitin fractions. First, exact proximate composition, total amino acids, fatty acids profile, and N-acetylglucosamine content of the prepupae samples were determined...
March 2018: Food Research International
https://www.readbyqxmd.com/read/29432036/effects-of-a-meal-feeding-regimen-and-the-availability-of-fresh-alfalfa-on-growth-performance-and-meat-and-bone-quality-of-broiler-genotypes
#3
B Koçer, M Bozkurt, G Ege, A E Tüzün, R Konak, O Olgun
1. The aim of this study was to identify a feeding regimen that encourages good pasture use in slow (SG) and fast (FG) growing broiler genotypes under free-range management. 2. SG and FG birds fed on either an ad libitum (ADB) or a meal feeding (MEF) programme was given free outdoor access with or without fresh alfalfa from d 22 to 72 and from d 22 to 45, respectively. In two consecutive trials, 800 birds of each genotype were included in a factorial design using groups of 40 birds replicated 5 times. 3. Fresh alfalfa consumption did not improve growth performance and meat quality attributes, whereas the feeding regimen had significant implications...
February 12, 2018: British Poultry Science
https://www.readbyqxmd.com/read/29431471/appetite-suppression-and-altered-food-preferences-coincide-with-changes-in-appetite-mediating-hormones-during-energy-deficit-at-high-altitude-but-are-not-affected-by-protein-intake
#4
J Philip Karl, Renee E Cole, Claire E Berryman, Graham Finlayson, Patrick N Radcliffe, Matthew T Kominsky, Nancy E Murphy, John W Carbone, Jennifer C Rood, Andrew J Young, Stefan M Pasiakos
Karl, J. Philip, Renee E. Cole, Claire E. Berryman, Graham Finlayson, Patrick N. Radcliffe, Matthew T. Kominsky, Nancy E. Murphy, John W. Carbone, Jennifer C. Rood, Andrew J. Young, and Stefan M. Pasiakos. Appetite Suppression and Altered Food Preferences Coincide with Changes in Appetite-Mediating Hormones During Energy Deficit at High Altitude, But Are Not Affected by Protein Intake. High Alt Med Biol. 00:000-000, 2018.-Anorexia and unintentional body weight loss are common during high altitude (HA) sojourn, but underlying mechanisms are not fully characterized, and the impact of dietary macronutrient composition on appetite regulation at HA is unknown...
February 12, 2018: High Altitude Medicine & Biology
https://www.readbyqxmd.com/read/29430842/glucagon-like-peptide-1-glp-1-based-therapeutics-current-status-and-future-opportunities-beyond-type-2-diabetes
#5
Jia Ying Cheang, Peter Michael Moyle
Glucagon-like peptide-1 (GLP-1) is secreted by intestinal L-cells following food intake, and plays an important role in glucose homeostasis due to its stimulation of glucose-dependent insulin secretion. Further, GLP-1 is also associated with protective effects on pancreatic β-cells and the cardiovascular system, reduced appetite, and weight loss, making GLP-1 derivatives an exciting treatment for type 2 diabetes and obesity. Despite these benefits, wild-type GLP-1 exhibits a short circulation time, due to its poor metabolic stability and rapid renal clearance, and needs to be administered by injection, making it a poor therapeutic agent...
February 11, 2018: ChemMedChem
https://www.readbyqxmd.com/read/29423219/the-effect-of-protein-supplementation-on-body-muscle-mass-and-fat-mass-in-post-bariatric-surgery-a-randomized-controlled-trial-rct-study-protocol
#6
Sahar D Al-Shamari, Mohamed Aly ElSherif, Wahiba Hamid, Fahad Hanna
Background: Severe weight loss through means of bariatric surgery has been associated with loss of muscle mass due to lack of absorption of protein. The aim of this RCT is to investigate the effectiveness of protein supplementation in reducing the risk of developing protein malnutrition and muscle wasting in post-bariatric surgery patients in Qatar. Methods and analysis: The study was based at the Department of bariatric and metabolic surgery, Doha metropolitan and regional areas...
2018: Archives of Public Health, Archives Belges de Santé Publique
https://www.readbyqxmd.com/read/29422993/mesenteric-injection-of-adipose-derived-mesenchymal-stem-cells-relieves-experimentally-induced-colitis-in-rats-by-regulating-th17-treg-cell-balance
#7
Zheng-Wei Fu, Zhen-Yu Zhang, Hai-Yan Ge
Efficient delivery routes are critical for the effectiveness of adipose-derived mesenchymal stem cells (ADMSCs) in treating inflammatory bowel disease (IBD). Conventional ADMSC delivery routes include local, intravenous and intraperitoneal injection. Whether mesenteric injection has potential in IBD treatment remains unknown. In the present study, we investigated the therapeutic effects of mesenteric injection of ADMSCs in a trinitrobenzene sulfonic acid-induced rat IBD model and explored whether this treatment affected T helper 17 (Th17)/regulatory T (Treg) cell ratio...
2018: American Journal of Translational Research
https://www.readbyqxmd.com/read/29422288/systems-signatures-reveal-unique-remission-path-of-type-2-diabetes-following-roux-en-y-gastric-bypass-surgery
#8
Qing-Run Li, Zi-Ming Wang, Nicolai J Wewer Albrechtsen, Dan-Dan Wang, Zhi-Duan Su, Xian-Fu Gao, Qing-Qing Wu, Hui-Ping Zhang, Li Zhu, Rong-Xia Li, SivHesse Jacobsen, Nils Bruun Jørgensen, Carsten Dirksen, Kirstine N Bojsen-Møller, Jacob S Petersen, Sten Madsbad, Trine R Clausen, Børge Diderichsen, Luo-Nan Chen, Jens J Holst, Rong Zeng, Jia-Rui Wu
Roux-en-Y Gastric bypass surgery (RYGB) is emerging as a powerful tool for treatment of obesity and may also cause remission of type 2 diabetes. However, the molecular mechanism of RYGB leading to diabetes remission independent of weight loss remains elusive. In this study, we profiled plasma metabolites and proteins of 10 normal glucose-tolerant obese (NO) and 9 diabetic obese (DO) patients before and 1-week, 3-months, 1-year after RYGB. 146 proteins and 128 metabolites from both NO and DO groups at all four stages were selected for further analysis...
February 2, 2018: EBioMedicine
https://www.readbyqxmd.com/read/29416651/jazf1-promotes-prostate-cancer-progression-by-activating-jnk-slug
#9
Yonghun Sung, Song Park, Si Jun Park, Jain Jeong, Minjee Choi, Jinhee Lee, Wookbong Kwon, Soyoung Jang, Mee-Hyun Lee, Dong Joon Kim, Kangdong Liu, Sung-Hyun Kim, Jae-Ho Lee, Yun-Sok Ha, Tae Gyun Kwon, Sanggyu Lee, Zigang Dong, Zae Young Ryoo, Myoung Ok Kim
Juxtaposed with another zinc finger protein 1 (Jazf1) is a zinc finger protein and is known to affect both prostate cancer and type 2 diabetes. Jazf1 inhibits testicular nuclear receptor 4 (TR4) activation through protein-protein interaction, which results in weight loss and alleviates diabetes. However, the role of Jazf1 in prostate cancer is still poorly understood. Hence, we investigated whether the expression of Jazf1 is associated with prostate cancer progression. We confirmed the upregulation of Jazf1 expression in human prostate tissue samples...
January 2, 2018: Oncotarget
https://www.readbyqxmd.com/read/29414598/combination-of-hindlimb-suspension-and-immobilization-by-casting-exaggerates-sarcopenia-by-stimulating-autophagy-but-does-not-worsen-osteopenia
#10
Toni L Speacht, Andrew R Krause, Jennifer L Steiner, Charles H Lang, Henry J Donahue
Astronauts in space experience a unique environment that causes the concomitant loss of bone and muscle. However, the interaction between these tissues and how osteopenia and sarcopenia affect each other is unclear. We explored this relationship by exaggerating unloading-induced muscle loss using a unilateral casting model in conjunction with hindlimb suspension (HLS). Five-month-old, male C57Bl/6J mice subjected to HLS for 2 weeks displayed a significant decrease in gastrocnemius and quadriceps weight (-9-10%), with a two-fold greater decrease in muscle mass observed in the HLS + casted limb...
February 2, 2018: Bone
https://www.readbyqxmd.com/read/29413672/impact-of-whey-protein-coating-incorporated-with-bifidobacterium-and-lactobacillus-on-sliced-ham-properties
#11
Joana Odila Pereira, José Soares, Maria J P Monteiro, Ana Gomes, Manuela Pintado
Edible coatings/films with functional ingredients may be a solution to consumers' demands for high-quality food products and an extended shelf-life. The aim of this work was to evaluate the antimicrobial efficiency of edible coatings incorporated with probiotics on sliced ham preservation. Coatings was developed based on whey protein isolates with incorporation of Bifidobacterium animalis Bb-12® or Lactobacillus casei-01. The physicochemical analyses showed that coating decreased water and weight loss on the ham...
January 31, 2018: Meat Science
https://www.readbyqxmd.com/read/29411665/immunomodulatory-potential-of-recombinant-filarial-protein-rwbl2-and-its-therapeutic-implication-in-experimental-ulcerative-colitis-in-mouse
#12
Namdev Togre, Priyanka Bhoj, Nitin Amdare, Kalyan Goswami, Aaditya Tarnekar, Moreshwar Shende
OBJECTIVE: Immunomodulation by helminth proteins has potential therapeutic implications in inflammatory bowel disease. In the present study, we have explored the therapeutic effect of a RAL family protein of filarial parasite Wuchereria bancrofti i.e., rWbL2 protein against DSS induced colitis in a mouse model. MATERIALS AND METHODS: Anti-inflammatory activity of rWbL2 on mice peritoneal exudate cells was analyzed under in vitro condition. The colitis mice were treated intraperitoneally (i...
February 7, 2018: Immunopharmacology and Immunotoxicology
https://www.readbyqxmd.com/read/29410479/the-efficacy-of-a-high-protein-low-glycemic-index-diet-intervention-in-non-obese-patients-with-asthma
#13
Nina Rica Wium Geiker, Louise L Toennesen, Arne Astrup, Vibeke Backer
BACKGROUND/OBJECTIVES: EFFORT Asthma study is a randomized controlled trial designed to assess the effects of diet and exercise in non-obese, untrained patients with asthma. We here present results from a subgroup of participants in the diet and control group to assess the feasibility of a high protein and low glycemic index (GI) diet and the effects on body composition. SUBJECTS/METHODS: Of the 149 subjects who were included in the study, 76 subjects (30 males) were randomized into either a diet group (n = 38) or a control group (n = 38) and included in the present analysis...
February 6, 2018: European Journal of Clinical Nutrition
https://www.readbyqxmd.com/read/29410438/chitosan-nanoparticles-having-higher-degree-of-acetylation-induce-resistance-against-pearl-millet-downy-mildew-through-nitric-oxide-generation
#14
Chandra Nayaka Siddaiah, Keelara Veerappa Harish Prasanth, Niranjan Raj Satyanarayana, Venkataramana Mudili, Vijai Kumar Gupta, Naveen Kumar Kalagatur, Tara Satyavati, Xiao-Feng Dai, Jie-Yin Chen, Andrei Mocan, Bhim Pratap Singh, Rakesh Kumar Srivastava
Downy mildew of pearl millet caused by the biotrophic oomycete Sclerospora graminicola is the most devastating disease which impairs pearl millet production causing huge yield and monetary losses. Chitosan nanoparticles (CNP) were synthesized from low molecular weight chitosan having higher degree of acetylation was evaluated for their efficacy against downy mildew disease of pearl millet caused by Sclerospora graminicola. Laboratory studies showed that CNP seed treatment significantly enhanced pearl millet seed germination percentage and seedling vigor compared to the control...
February 6, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29410348/caloric-restriction-improves-glucose-homeostasis-yet-increases-cardiometabolic-risk-in-caveolin-1-deficient-mice
#15
Korapat Mayurasakorn, Nurul Hasanah, Tsuyoshi Homma, Mika Homma, Isis Katayama Rangel, Amanda E Garza, Jose R Romero, Gail K Adler, Gordon H Williams, Luminita H Pojoga
BACKGROUND AND PURPOSE: The plasma membrane protein caveolin-1 (CAV-1) has been shown to be involved in modulating glucose homeostasis and the actions of the renin-angiotensin-aldosterone system (RAAS). Caloric restriction (CR) is widely accepted as an effective therapeutic approach to improve insulin sensitivity and reduce the severity of diabetes. Recent data indicate that polymorphisms of the CAV-1 gene are strongly associated with insulin resistance, hypertension and metabolic abnormalities in non-obese individuals...
February 1, 2018: Metabolism: Clinical and Experimental
https://www.readbyqxmd.com/read/29409375/films-based-on-soy-protein-agar-blends-for-wound-dressing-effect-of-different-biopolymer-proportions-on-the-drug-release-rate-and-the-physical-and-antibacterial-properties-of-the-films
#16
Josefina Rivadeneira, M C Audisio, Alejandro Gorustovich
No single material can provide all requirements for wound dressings. Here, we evaluated the influence of different soy protein isolate and agar proportions (3:1, 1:1, and 1:3) in blend films on some of their physical-chemical and antibacterial properties to elucidate their potential as wound dressings. The films were synthesized by the gel casting method and ciprofloxacin hydrochloride was incorporated into the films. Films were characterized based on their surface morphology, water uptake ability, and weight loss profile...
January 1, 2018: Journal of Biomaterials Applications
https://www.readbyqxmd.com/read/29406569/neospora-caninum-and-ehrlichia-canis-co-infection-in-a-dog-with-meningoencephalitis
#17
Itamar Aroch, Gad Baneth, Harold Salant, Yaarit Nachum-Biala, Asaf Berkowitz, Merav Shamir, Orit Chai
An 8-year-old mixed-breed dog was presented for acute, progressive weakness and ataxia, inappetence, and weight loss. The patient was mentally normal, but nonambulatory, with a right head tilt, right positional ventral strabismus, and slight head tremors. A neurologic lesion was localized to the cerebellum and right brainstem. Cerebrospinal fluid (CSF) analysis showed a markedly increased protein concentration and mixed pleocytosis, with eosinophil predominance (44%), intracytoplasmic inclusions within eosinophils, consistent with Ehrlichia canis (E canis) morulae, and Toxoplasma gondii (T gondii) or Neospora caninum (N caninum) tachyzoites within eosinophils and monocytes...
February 6, 2018: Veterinary Clinical Pathology
https://www.readbyqxmd.com/read/29402771/micro-integral-membrane-protein-mimp-a-newly-discovered-anti-inflammatory-protein-of-lactobacillus-plantarum-enhances-the-gut-barrier-and-modulates-microbiota-and-inflammatory-cytokines
#18
Mingming Yin, Xuebing Yan, Wenhao Weng, Yongzhi Yang, Renyuan Gao, Minfeng Liu, Cheng Pan, Qi Zhu, Hao Li, Qing Wei, Tongyi Shen, Yanlei Ma, Huanlong Qin
BACKGROUND/AIMS: Recent studies have demonstrated that the manipulation of the gut microbiome represents a promising treatment for inflammatory bowel disease (IBD). We previously identified micro integral membrane protein (MIMP) as the smallest domain of surface layer protein from Lactobacillus Plantarum. However, the therapeutic relevance of MIMP in IBD remains unknown. METHODS: We initially employed a dextran sodium sulphate (DSS)-induced colitis model and evaluated the effect of MIMP on the inflammation response, intestinal barrier and gut microbiota using histological examination, Fluorescein isothiocyanate-Dextran detection and pyrosequencing analysis respectively...
January 25, 2018: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/29401631/short-term-methionine-deprivation-improves-metabolic-health-via-sexually-dimorphic-mtorc1-independent-mechanisms
#19
Deyang Yu, Shany E Yang, Blake R Miller, Jaclyn A Wisinski, Dawn S Sherman, Jacqueline A Brinkman, Jay L Tomasiewicz, Nicole E Cummings, Michelle E Kimple, Vincent L Cryns, Dudley W Lamming
Obesity and diabetes are major challenges to global health, and there is an urgent need for interventions that promote weight loss. Dietary restriction of methionine promotes leanness and improves metabolic health in mice and humans. However, poor long-term adherence to this diet limits its translational potential. In this study, we develop a short-term methionine deprivation (MD) regimen that preferentially reduces fat mass, restoring normal body weight and glycemic control to diet-induced obese mice of both sexes...
January 30, 2018: FASEB Journal: Official Publication of the Federation of American Societies for Experimental Biology
https://www.readbyqxmd.com/read/29398867/diet-switch-and-omega-3-hydroxy-fatty-acids-display-differential-hepatoprotective-effects-in-an-obesity-nonalcoholic-fatty-liver-disease-model-in-mice
#20
Roberto Rodriguez-Echevarria, Jose Macias-Barragan, Marcela Parra-Vargas, Judith Rebeca Davila-Rodriguez, Eduardo Amezcua-Galvez, Juan Armendariz-Borunda
AIM: To study the effect of 18-hydroxy-eicosapentaenoic acid (18-HEPE) and 17-hydroxy-docosahexaenoic acid (17-HDHA) in a murine model of obesity/nonalcoholic fatty liver disease. METHODS: C57BL/6 mice were fed with standard chow diet (CD) or high-fat, fructose-enriched diet (HFD) for 16 wk. Then, three groups were treated for 14 d with either, diet switch (HFD for CD), 18-HEPE, or 17-HDHA. Weight and fasting glucose were recorded on a weekly basis. Insulin tolerance test was performed at the end of treatment...
January 28, 2018: World Journal of Gastroenterology: WJG
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