keyword
MENU ▼
Read by QxMD icon Read
search

Protein AND weight loss

keyword
https://www.readbyqxmd.com/read/29040448/male-brown-fat-specific-double-knockout-of-igfir-ir-atrophy-mitochondrial-fission-failure-impaired-thermogenesis-and-obesity
#1
Vanesa Viana-Huete, Carlos Guillén, Gema García, Silvia Fernández, Ana García-Aguilar, C R Kahn, Manuel Benito
It is unknown how the lack of IR (insulin receptor)/ IGFIR (insulin like growth factor receptor) in a tissue-specific manner does affect brown fat development and mitochondrial integrity and function and its impact on the redistribution of the adipose organ and the metabolic status. To address this important issue, we have developed the IR/IGFIR double knockout in brown adipose tissue-specific manner (DKO). Lack of those receptors caused a severe brown fat atrophy, an enhanced beige cell clusters in inguinal fat, loss of mitochondrial mass, mitochondrial damage related to cristae disruption, and the loss of proteins involved in autophagosome formation, mitophagy, mitochondrial quality control and dynamics and thermogenesis...
October 10, 2017: Endocrinology
https://www.readbyqxmd.com/read/29035973/the-relevance-of-dietary-protein-after-bariatric-surgery-what-do-we-know
#2
Nele Steenackers, Ina Gesquiere, Christophe Matthys
PURPOSE OF REVIEW: The growing obesity epidemic is associated with an increased demand for bariatric surgery with Roux-en-Y Gastric Bypass and Sleeve Gastrectomy as the most widely performed procedures. Despite beneficial consequences, nutritional complications may arise because of anatomical and physiological changes of the gastrointestinal tract. The purpose of this review is to provide an update of the recent additions to our understanding of the impact of bariatric surgery on the intake, digestion and absorption of dietary protein...
October 14, 2017: Current Opinion in Clinical Nutrition and Metabolic Care
https://www.readbyqxmd.com/read/29033897/evaluation-of-cardiometabolic-parameters-among-obese-women-using-oral-contraceptives
#3
Júnia Raquel Dutra Ferreira, Milena Magalhães Aleluia, Camylla Vilas Boas Figueiredo, Larissa Castro de Lima Vieira, Rayra Pereira Santiago, Caroline Conceição da Guarda, Cynara Gomes Barbosa, Ricardo Riccio Oliveira, Elisângela Vitória Adorno, Marilda de Souza Gonçalves
BACKGROUND: Combined oral contraceptive (COC) use has been associated with an unfavorable impact on carbohydrate and lipid metabolism in diverse populations of normal weight and obese women. The present study aimed to evaluate the cardiometabolic and inflammatory profiles of women in northeastern Brazil with respect to COC use and obesity. METHODS: We performed a cross-sectional study to verify cardiovascular parameters, including blood pressure (BP), fasting serum glucose, lipid, and inflammatory profile, in a population of women aged 15-45 years, considering obesity and COC use...
2017: Frontiers in Endocrinology
https://www.readbyqxmd.com/read/29032335/identification-of-the-optimal-dose-and-calpain-system-regulation-of-tetramethylpyrazine-on-the-prevention-of-skeletal-muscle-atrophy-in-hindlimb-unloading-rats
#4
Jie Zhang, Yang Li, Guangyue Li, Xiufeng Ma, Huiping Wang, Nandu Goswami, Helmut Hinghofer-Szalkay, Hui Chang, Yunfang Gao
Previous studies in our lab have shown that tetramethylpyrazine (TMP) could effectively attenuate disuse induced muscle atrophy. In order to screening out the optimal dose of tetramethylpyrazine (TMP) for protection against disuse induced muscle atrophy in hindlimb unloading (HLU) rats, in this study, we compared effects of 4 TMP doses on muscle wet weight (MWW), the ratios of muscle wet weight/body weight (MWW/BW) and muscle wet weight/dry weight (MWW/DW), fiber type composition, as well as cross-sectional area (CSA) in soleus (SOL) muscle...
October 12, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/29031712/mitochondrial-uncoupling-in-the-melanocortin-system-differentially-regulates-npy-and-pomc-neurons-to-promote-weight-loss
#5
Natalie Jane Michael, Stephanie Elise Simonds, Marco van den Top, Michael Alexander Cowley, David Spanswick
OBJECTIVE: The mitochondrial uncoupling agent 2,4-dinitrophenol (DNP), historically used as a treatment for obesity, is known to cross the blood-brain-barrier, but its effects on central neural circuits controlling body weight are largely unknown. As hypothalamic melanocortin neuropeptide Y/agouti-related protein (NPY/AgRP) and pro-opiomelanocortin (POMC) neurons represent key central regulators of food intake and energy expenditure we investigated the effects of DNP on these neurons, food intake and energy expenditure...
October 2017: Molecular Metabolism
https://www.readbyqxmd.com/read/29031208/phytoecdysteroids-from-ajuga-iva-act-as-potential-antidiabetic-agent-against-alloxan-induced-diabetic-male-albino-rats
#6
Jin-Jun Wang, Hao Jin, Shao-Ling Zheng, Peng Xia, Yong Cai, Xiao-Jie Ni
The present study investigated the protective effect of phytoecdysteroids extracted from the Ajuga iva plant on body weight changes, blood glucose, insulin total protein, blood urea nitrogen (BUN), creatinine, triglycerides (TG), cholesterol, lipid peroxidation, antioxidant enzymes, pancreatic histopathology and hexokinase-I expression in the alloxan-induced diabetic rats. Experimental diabetes was induced following 15day intraperitoneal administration of alloxan. The rats were divided into four groups. Group I served as a sham group, and group II served as the diabetic control...
October 11, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/29030256/ficus-virens-proanthocyanidins-induced-apoptosis-in-breast-cancer-cells-concomitantly-ameliorated-5-fluorouracil-induced-intestinal-mucositis-in-rats
#7
Xiao-Xin Chen, Kar Ho Lam, Qing-Xi Chen, George Pak-Heng Leung, Sydney Chi Wai Tang, Stephen Cho-Wing Sze, Jian-Bo Xiao, Feng Feng, Ying Wang, Kalin Yan-Bo Zhang, Zhang-Jin Zhang
5-Fluorouracil (5-FU) is a commonly used chemotherapeutic agent for breast cancer. However, its use often leads to drug resistance and mucositis. This study aimed to investigate whether proanthocyanidins from Ficus virens possessed anti-breast cancer and anti-mucositis activities. The results showed that the cytotoxic effects of the proanthocyanidins against MDA-MB-231 and MCF-7 breast cancer cells were in the order of stem barks proanthocyanidins (SPAs) > leaves proanthocyanidins > fruits proanthocyanidins...
October 10, 2017: Food and Chemical Toxicology
https://www.readbyqxmd.com/read/29028547/-borneol-improves-the-efficacy-of-edaravone-against-dss-induced-colitis-by-promoting-m2-macrophages-polarization-via-jak2-stat3-signaling-pathway
#8
Xiong Zhang, Fang Xu, Li Liu, Lili Feng, Xuefeng Wu, Yan Shen, Yang Sun, Xudong Wu, Qiang Xu
Compound edaravone injection (C.EDA), a compound preparation composed of edaravone (EDA) and (+)-Borneol with the mass ratio of 4: 1, displays a better anti-inflammatory activity than EDA. However, its precise mechanism remains to be further studied. In this work, we investigated whether (+)-Borneol could improve the efficacy of EDA against DSS-induced colitis. We found that C.EDA at 7.5 and 15mg/kg could significantly relieve the disease activity index (DAI) and reduce the loss of body weight and colon length in a dose-dependent manner, while EDA or (+)-Borneol alone only had moderate effects even at the highest dose...
October 10, 2017: International Immunopharmacology
https://www.readbyqxmd.com/read/29027705/effects-of-dietary-supplementation-of-spices-on-forage-degradability-ruminal-fermentation-in-vivo-digestibility-growth-performance-and-nitrogen-balance-in-black-bengal-goat
#9
M R Chowdhury, M M H Khan, S U Mahfuz, M A Baset
The objective of the study was to evaluate the effects of spices on forage utilization and nitrogen (N) emission using in vitro and in vivo approach. A 6 × 5 factorial triplicate arrangement was used to assess the in vitro degradability of rice straw with control (without spices) and individual (40 mg/g rice straw) spices (cumin, coriander, clove, black cumin, turmeric) at five different incubation times. In vitro dry matter (DM) and organic matter (OM) degradability of rice straw were highest in presence of spices except for clove...
October 13, 2017: Journal of Animal Physiology and Animal Nutrition
https://www.readbyqxmd.com/read/29024428/heat-shock-protein-60-in-obesity-effect-of-bariatric-surgery-and-its-relation-to-inflammation-and-cardiovascular-risk
#10
Henrike Sell, Christine Poitou, Christiane Habich, Jean-Luc Bouillot, Jürgen Eckel, Karine Clément
OBJECTIVE: Heat shock protein 60 (Hsp60) is an adipokine, and its serum concentrations are higher in patients with obesity compared to lean patients. This study aimed to analyze the effect of bariatric surgery on circulating concentrations of Hsp60 in morbid obesity and their correlation with inflammation and metabolic and cardiovascular risk. METHODS: Fifty-three females with morbid obesity undergoing bariatric surgery were enrolled. Serum parameters and anthropometric measures were obtained at baseline and 3 to 12 months post surgery...
October 11, 2017: Obesity
https://www.readbyqxmd.com/read/29023414/3-5-6-7-8-3-4-heptamethoxyflavone-ameliorates-depressive-like-behavior-and-hippocampal-neurochemical-changes-in-chronic-unpredictable-mild-stressed-mice-by-regulating-the-brain-derived-neurotrophic-factor-requirement-for-erk-activation
#11
Atsushi Sawamoto, Satoshi Okuyama, Yoshiaki Amakura, Morio Yoshimura, Takashi Yamada, Hidehiko Yokogoshi, Mitsunari Nakajima, Yoshiko Furukawa
We previously reported that the subcutaneous administration of 3,5,6,7,8,3',4'-heptamethoxyflavone (HMF), a citrus polymethoxyflavone, attenuated depressive-like behavior and increased the expression of brain-derived neurotrophic factor (BDNF) in the hippocampus of a corticosterone-induced depression-like mouse model. We herein demonstrated that (1) HMF was detectable in the brain 10 and 30 min after its oral administration, (2) orally administered HMF improved chronic unpredictable mild stress (CUMS)-induced pathological conditions, including body weight loss and depressive-like behavior, and CUMS-induced neurochemical changes, such as reduction in BDNF expression, decrease in neurogenesis, and decreased level of phosphorylated calcium-calmodulin-dependent protein kinase II in the hippocampus, and (3) these effects of HMF were inhibited by the pre-administration of U0126, a mitogen-activated protein (MAP) kinase inhibitor...
October 12, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29022562/ketogenic-diet-in-endocrine-disorders-current-perspectives
#12
REVIEW
L Gupta, D Khandelwal, S Kalra, P Gupta, D Dutta, S Aggarwal
Ketogenic diet (KD) is a high-fat, adequate-protein, and low-carbohydrate diet that leads to nutritional ketosis, long known for antiepileptic effects and has been used therapeutically to treat refractory epilepsy. This review attempts to summarize the evidence and clinical application of KD in diabetes, obesity, and other endocrine disorders. KD is usually animal protein based. An empiric vegetarian Indian variant of KD has been provided keeping in mind the Indian food habits. KD has beneficial effects on cardiac ischemic preconditioning, improves oxygenation in patients with respiratory failure, improves glycemic control in diabetics, is associated with significant weight loss, and has a beneficial impact on polycystic ovarian syndrome...
October 2017: Journal of Postgraduate Medicine
https://www.readbyqxmd.com/read/29019954/weight-loss-in-advanced-chronic-kidney-disease-should-we-consider-individualised-qualitative-ad-libitum-diets-a-narrative-review-and-case-study
#13
Capizzi Irene, Teta Luigi, Vigotti Federica Neve, Tognarelli Giuliana, Consiglio Valentina, Scognamiglio Stefania, Piccoli Giorgina Barbara
In advanced chronic kidney disease, obesity may bring a survival advantage, but many transplant centres demand weight loss before wait-listing for kidney graft. The case here described regards a 71-year-old man, with obesity-related glomerulopathy; referral data were: weight 110 kg, Body Mass Index (BMI) 37 kg/m², serum creatinine (sCr) 5 mg/dL, estimated glomerular filtration rate (eGFR) 23 mL/min, blood urea nitrogen (BUN) 75 mg/dL, proteinuria 2.3 g/day. A moderately restricted, low-protein diet allowed reduction in BUN (45-55 mg/dL) and good metabolic and kidney function stability, with a weight increase of 6 kg...
October 11, 2017: Nutrients
https://www.readbyqxmd.com/read/29018444/mucosa-associated-lymphoid-tissue-lymphoma-translocation-protein-1-positively-modulates-matrix-metalloproteinase-9-production-in-alveolar-macrophages-upon-toll-like-receptor-7-signaling-and-influenza-virus-infection
#14
Yu-Hsiang Lee, Juin-Hua Huang, Tzu-Hsuan Chang, Hung-Chih Yang, Betty A Wu-Hsieh
Influenza A virus (IAV) infection causes significant morbidity and mortality worldwide. Matrix metalloproteinase-9 (MMP-9) degrades extracellular matrix and is involved in the pathology of influenza. It has been reported that MMP-9 mediates neutrophil migration in IAV infection. Whether alveolar macrophages, the first immune cells that encounter IAV, produce MMP-9, and the mechanism of its regulation have never been investigated. As Toll-like receptor 7 (TLR7) is one of the receptors in innate immune cells that recognize IAV, we used TLR7 agonists and IAV to stimulate alveolar macrophage MH-S cells, primary macrophages, and bone marrow neutrophils...
2017: Frontiers in Immunology
https://www.readbyqxmd.com/read/29016861/dj-1-is-a-redox-sensitive-adapter-protein-for-high-molecular-weight-complexes-involved-in-regulation-of-catecholamine-homeostasis
#15
Dominik Piston, Lydia Alvarez-Erviti, Vikas Bansal, Daniela Gargano, Zhi Yao, Gyorgy Szabadkai, Mark Odell, M Rhyan Puno, Benny Björkblom, Jodi Maple-Grødem, Peter Breuer, Oliver Kaut, Jan Petter Larsen, Stefan Bonn, Simon Geir Møller, Ullrich Wüllner, Anthony H V Schapira, Matthew E Gegg
DJ-1 is an oxidation sensitive protein encoded by the PARK7 gene. Mutations in PARK7 are a rare cause of familial recessive Parkinson's disease (PD), but growing evidence suggests involvement of DJ-1 in idiopathic PD. The key clinical features of PD, rigidity and bradykinesia, result from neurotransmitter imbalance, particularly the catecholamines dopamine (DA) and noradrenaline. We report in human brain and human SH-SY5Y neuroblastoma cell lines that DJ-1 predominantly forms high molecular weight (HMW) complexes that included RNA metabolism proteins hnRNPA1 and PABP1 and the glycolysis enzyme GAPDH...
October 15, 2017: Human Molecular Genetics
https://www.readbyqxmd.com/read/28994516/the-implication-of-combat-stress-and-ptsd-trajectories-in-metabolic-syndrome-and-elevated-c-reactive-protein-levels-a-longitudinal-study
#16
Zahava Solomon, Yafit Levin, Einor Ben Assayag, Orit Furman, Shani Shenhar-Tsarfaty, Shlomo Berliner, Avi Ohry
OBJECTIVE: This study sheds light on the importance of long-term follow-up of trauma survivors, posttraumatic stress disorder (PTSD) trajectories, and early detection of health risk factors in trauma survivors. The present study prospectively assessed the following over 23 years: (1) the association of psychological and physiologic stress during captivity with elevated C-reactive protein (CRP) levels and metabolic syndrome (MetS), which includes hypertension; elevated levels of insulin, triglycerides, and fasting glucose; decreased levels of high-density lipoprotein cholesterol; and obesity and (2) the implication of PTSD trajectories in elevated CRP levels and MetS...
October 3, 2017: Journal of Clinical Psychiatry
https://www.readbyqxmd.com/read/28993428/disease-modifying-effects-of-ganglioside-gm1-in-huntington-s-disease-models
#17
Melanie Alpaugh, Danny Galleguillos, Juan Forero, Luis Carlos Morales, Sebastian W Lackey, Preeti Kar, Alba Di Pardo, Andrew Holt, Bradley J Kerr, Kathryn G Todd, Glen B Baker, Karim Fouad, Simonetta Sipione
Huntington's disease (HD) is a progressive neurodegenerative disorder characterized by motor, cognitive and psychiatric problems. Previous studies indicated that levels of brain gangliosides are lower than normal in HD models and that administration of exogenous ganglioside GM1 corrects motor dysfunction in the YAC128 mouse model of HD In this study, we provide evidence that intraventricular administration of GM1 has profound disease-modifying effects across HD mouse models with different genetic background...
October 9, 2017: EMBO Molecular Medicine
https://www.readbyqxmd.com/read/28992008/effects-of-dietary-l-methionine-supplementation-on-the-growth-performance-carcass-characteristics-meat-quality-and-muscular-antioxidant-capacity-and-myogenic-gene-expression-in-low-birth-weight-pigs
#18
Y Li, H Zhang, Y P Chen, Z X Ying, W P Su, L L Zhang, T Wang
The aim of the present study was to investigate the effects of dietary Met supplementation on the growth performance, carcass characteristics, meat quality, and muscular antioxidant capacity and myogenic gene expression in low birth weight (LBW) pigs. Thirty normal birth weight (NBW) and 60 LBW female piglets were selected at birth. In each litter, after weaning, 1 of the LBW piglets (LBW-CON group) and 1 of the NBW piglets (NBW-CON group) were fed the basal diets and 1 LBW littermate was fed the basal diet supplemented with Met (LBW-MET group)...
September 2017: Journal of Animal Science
https://www.readbyqxmd.com/read/28991472/the-discovery-of-a-dual-ttk-protein-kinase-cdc2-like-kinase-clk2-inhibitor-for-the-treatment-of-triple-negative-breast-cancer-initiated-from-a-phenotypic-screen
#19
Jennifer R Riggs, Mark Nagy, Jan Elsner, Paul Erdman, Dan Cashion, Dale Robinson, Roy Harris, Dehua Huang, Lida Tehrani, Gordafaried Deyanat-Yazdi, Rama Krishna Narla, Xiaohui Peng, Tam Tran, Leo Barnes, Terra Miller, Jason Katz, Yang Tang, Ming Chen, Mehran F Moghaddam, Sogole Bahmanyar, Barbra Pagarigan, Silvia L Delker, Laurie LeBrun, Philip Paul Chamberlain, Andrew Calabrese, Stacie S Canan, Katerina Leftheris, Dan Zhu, John F Boylan
Triple negative breast cancer (TNBC) remains a serious unmet medical need with discouragingly high relapse rates. We report here the synthesis and structure-activity relationship (SAR) of a novel series of 2,4,5-trisubstituted-7H-pyrrolo[2,3-d]pyrimidines with potent activity against TNBC tumor cell lines. These compounds were discovered from a TNBC phenotypic screen and possess a unique dual inhibition profile targeting TTK (mitotic exit) and CLK2 (mRNA splicing). Design and optimization, driven with a TNBC tumor cell assay, identified potent and selective compounds with favorable in vitro and in vivo activity profiles and good iv PK properties...
October 9, 2017: Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/28988565/effect-of-age-and-gender-on-carcass-traits-and-meat-quality-of-farmed-brown-hares
#20
A Trocino, M Birolo, S Dabbou, F Gratta, N Rigo, G Xiccato
A total of 48 sub-adult hares and adult reproducing farmed hares were used to characterize carcass and meat traits according to the age and gender of animals. With respect to carcass traits, when age increased, the carcass weight significantly increased (2022 to 3391 g; P<0.001), but dressing out percentages did not change. The dissectible fat (1.3% to 2.2%; P<0.05) and Longissimus lumborum (LL) proportions (13.5% to 14.5%; P<0.001) and muscle-to-bone ratio of hind legs (5.11 to 6.23; P<0.001) increased, whereas the hind leg proportions decreased (37...
October 9, 2017: Animal: An International Journal of Animal Bioscience
keyword
keyword
14933
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"