keyword
MENU ▼
Read by QxMD icon Read
search

Adaptive thermogenesis

keyword
https://www.readbyqxmd.com/read/29216033/fattening-the-role-of-ca2-cycling-in-adaptive-thermogenesis
#1
Daniel Gamu, A Russell Tupling
No abstract text is available yet for this article.
December 7, 2017: Nature Medicine
https://www.readbyqxmd.com/read/29212043/inhibition-of-mitochondrial-ucp1-and-ucp3-by-purine-nucleotides-and-phosphate
#2
Gabriel Macher, Melanie Koehler, Anne Rupprecht, Jürgen Kreiter, Peter Hinterdorfer, Elena E Pohl
Mitochondrial membrane uncoupling protein 3 (UCP3) is not only expressed in skeletal muscle and heart, but also in brown adipose tissue (BAT) alongside UCP1, which facilitates a proton leak to support non-shivering thermogenesis. In contrast to UCP1, the transport function and molecular mechanism of UCP3 regulation are poorly investigated, although it is generally agreed upon that UCP3, analogous to UCP1, transports protons, is activated by free fatty acids (FFAs) and is inhibited by purine nucleotides (PN)...
December 3, 2017: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/29199788/adaptive-thermogenesis-and-changes-in-body-composition-and-physical-fitness-in-army-cadets
#3
Juliano H Borges, Gary R Hunter, Analiza M Silva, Vagner X Cirolini, Raquel D Langer, Mauro A Páscoa, Gil Guerra, Ezequiel M Gonçalves
BACKGROUND: To analyze the association between a 34-week military training on body composition, physical fitness and compensatory changes in resting energy expenditure (REE) recognized as adaptive thermogenesis (AT). We also explored if regional body composition changes were related to AT. METHODS: Twenty-nine male army cadets, aged 17 to 22 years were tested at baseline (T0) and after 34-weeks military training (T1). Physical training was performed 5 days/week during 90 minutes/day...
December 1, 2017: Journal of Sports Medicine and Physical Fitness
https://www.readbyqxmd.com/read/29153407/brown-fat-akt2-is-a-cold-induced-kinase-that-stimulates-chrebp-mediated-de-novo-lipogenesis-to-optimize-fuel-storage-and-thermogenesis
#4
Joan Sanchez-Gurmaches, Yuefeng Tang, Naja Zenius Jespersen, Martina Wallace, Camila Martinez Calejman, Sharvari Gujja, Huawei Li, Yvonne J K Edwards, Christian Wolfrum, Christian M Metallo, Søren Nielsen, Camilla Scheele, David A Guertin
Brown adipose tissue (BAT) is a therapeutic target for metabolic diseases; thus, understanding its metabolic circuitry is clinically important. Many studies of BAT compare rodents mildly cold to those severely cold. Here, we compared BAT remodeling between thermoneutral and mild-cold-adapted mice, conditions more relevant to humans. Although BAT is renowned for catabolic β-oxidative capacity, we find paradoxically that the anabolic de novo lipogenesis (DNL) genes encoding ACLY, ACSS2, ACC, and FASN were among the most upregulated by mild cold and that, in humans, DNL correlates with Ucp1 expression...
November 15, 2017: Cell Metabolism
https://www.readbyqxmd.com/read/29138228/low-protein-diet-induced-hyperphagia-and-adiposity-are-modulated-through-interactions-involving-thermoregulation-motor-activity-and-protein-quality-in-mice
#5
Anne Blais, Catherine Chaumontet, Dalila Azzout-Marniche, Julien Piedcoq, Gilles Fromentin, Claire Gaudichon, Daniel Tomé, Patrick C Even
Low-protein (LP) containing diets can induce overeating in rodents and possibly in humans in an effort to meet protein requirement but the consequences on energy expenditure (EE) are unclear. The present study evaluated the changes induced by reducing dietary protein from 20% to 6%, using either soy protein or casein, on energy intake, body composition and EE in mice housed at 22°C or at 30°C (thermal-neutrality). LP feeding increased energy intake and adiposity, more in soy fed than in casein fed mice, but also increased EE thus limiting fat accumulation...
November 14, 2017: American Journal of Physiology. Endocrinology and Metabolism
https://www.readbyqxmd.com/read/29113988/seasonal-variation-in-the-thermal-responses-to-changing-environmental-temperature-in-the-world-s-northernmost-landbird
#6
Andreas Nord, Lars P Folkow
Arctic homeotherms counter challenges at high latitudes using a combination of seasonal adjustments in pelage/plumage, fat deposition, and intricate thermoregulatory adaptations. However, there are still gaps in our understanding of their thermal responses to cold, particularly in Arctic birds. Here, we have studied the potential use of local heterothermy (i.e., tissue cooling that can contribute to significantly lower heat loss rate) in Svalbard ptarmigan (Lagopus muta hyperborea) - the world's northernmost landbird...
November 7, 2017: Journal of Experimental Biology
https://www.readbyqxmd.com/read/29113711/the-lives-and-times-of-brown-adipokines
#7
REVIEW
Francesc Villarroya, Aleix Gavaldà-Navarro, Marion Peyrou, Joan Villarroya, Marta Giralt
Brown adipose tissue (BAT) is responsible for adaptive non-shivering thermogenesis. Moreover, brown fat secretes regulatory factors, so-called brown adipokines, that have autocrine, paracrine, and endocrine actions. Brown adipokines are either polypeptides or nonpeptidic molecules including lipid molecules and microRNAs. The secretory properties of brown fat are essential for tissue remodeling adaptations to thermogenic necessities. The endocrine properties of brown adipokines are thought to contribute to the association between BAT activity and a healthy metabolic profile in relation to glucose and lipid homeostasis...
November 4, 2017: Trends in Endocrinology and Metabolism: TEM
https://www.readbyqxmd.com/read/29078316/reconstitution-of-ucp1-using-crispr-cas9-in-the-white-adipose-tissue-of-pigs-decreases-fat-deposition-and-improves-thermogenic-capacity
#8
Qiantao Zheng, Jun Lin, Jiaojiao Huang, Hongyong Zhang, Rui Zhang, Xueying Zhang, Chunwei Cao, Catherine Hambly, Guosong Qin, Jing Yao, Ruigao Song, Qitao Jia, Xiao Wang, Yongshun Li, Nan Zhang, Zhengyu Piao, Rongcai Ye, John R Speakman, Hongmei Wang, Qi Zhou, Yanfang Wang, Wanzhu Jin, Jianguo Zhao
Uncoupling protein 1 (UCP1) is localized on the inner mitochondrial membrane and generates heat by uncoupling ATP synthesis from proton transit across the inner membrane. UCP1 is a key element of nonshivering thermogenesis and is most likely important in the regulation of body adiposity. Pigs (Artiodactyl family Suidae) lack a functional UCP1 gene, resulting in poor thermoregulation and susceptibility to cold, which is an economic and pig welfare issue owing to neonatal mortality. Pigs also have a tendency toward fat accumulation, which may be linked to their lack of UCP1, and thus influences the efficiency of pig production...
November 7, 2017: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/29046921/pioglitazone-reduces-cold-induced-brown-fat-glucose-uptake-despite-induction-of-browning-in-cultured-human-adipocytes-a-randomised-controlled-trial-in-humans
#9
Rebecca K C Loh, Melissa F Formosa, Nina Eikelis, David A Bertovic, Mitchell J Anderson, Shane A Barwood, Shane Nanayakkara, Neale D Cohen, Andre La Gerche, Anne T Reutens, Kenneth S Yap, Thomas W Barber, Gavin W Lambert, Martin H Cherk, Stephen J Duffy, Bronwyn A Kingwell, Andrew L Carey
AIMS/HYPOTHESIS: Increasing brown adipose tissue (BAT) activity is a possible therapeutic strategy to increase energy expenditure and glucose and lipid clearance to ameliorate obesity and associated comorbidities. The thiazolidinedione (TZD) class of glucose-lowering drugs increase BAT browning in preclinical experimental models but whether these actions extend to humans in vivo is unknown. The aim of this study was to determine the effect of pioglitazone treatment on adipocyte browning and adaptive thermogenesis in humans...
October 18, 2017: Diabetologia
https://www.readbyqxmd.com/read/28988768/crosstalk-between-kcnk3-mediated-ion-current-and-adrenergic-signaling-regulates-adipose-thermogenesis-and-obesity
#10
Yi Chen, Xing Zeng, Xuan Huang, Sara Serag, Clifford J Woolf, Bruce M Spiegelman
Adrenergic stimulation promotes lipid mobilization and oxidation in brown and beige adipocytes, where the harnessed energy is dissipated as heat in a process known as adaptive thermogenesis. The signaling cascades and energy-dissipating pathways that facilitate thermogenesis have been extensively described, yet little is known about the counterbalancing negative regulatory mechanisms. Here, we identify a two-pore-domain potassium channel, KCNK3, as a built-in rheostat negatively regulating thermogenesis. Kcnk3 is transcriptionally wired into the thermogenic program by PRDM16, a master regulator of thermogenesis...
November 2, 2017: Cell
https://www.readbyqxmd.com/read/28980233/molecular-and-neuroendocrine-mechanisms-of-avian-seasonal-reproduction
#11
T Katherine Tamai, Takashi Yoshimura
Animals living outside tropical zones experience seasonal changes in the environment and accordingly, adapt their physiology and behavior in reproduction, molting, and migration. Subtropical birds are excellent models for the study of seasonal reproduction because of their rapid and dramatic response to changes in photoperiod. For example, testicular weight typically changes by more than a 100-fold. In birds, the eyes are not necessary for seasonal reproduction, and light is instead perceived by deep brain photoreceptors...
2017: Advances in Experimental Medicine and Biology
https://www.readbyqxmd.com/read/28978546/subcutaneous-inguinal-white-adipose-tissue-is-responsive-to-but-dispensable-for-the-metabolic-health-benefits-of-exercise
#12
Willem T Peppler, Logan K Townsend, Carly M Knuth, Michelle T Foster, David C Wright
Exercise training has robust effects on subcutaneous inguinal white adipose tissue (iWAT), characterized by a shift to a brown adipose tissue (BAT) like phenotype. Consistent with this, transplantation of exercise-trained iWAT into sedentary rodents activates thermogenesis and improves glucose homeostasis, suggesting that iWAT metabolism may contribute to the beneficial effects of exercise. However, it is yet to be determined if adaptations in iWAT are necessary for the beneficial systemic effects of exercise...
October 3, 2017: American Journal of Physiology. Endocrinology and Metabolism
https://www.readbyqxmd.com/read/28977817/global-warming-and-obesity-a-systematic-review
#13
REVIEW
R An, M Ji, S Zhang
Global warming and the obesity epidemic are two unprecedented challenges mankind faces today. A literature search was conducted in the PubMed, Web of Science, EBSCO and Scopus for articles published until July 2017 that reported findings on the relationship between global warming and the obesity epidemic. Fifty studies were identified. Topic-wise, articles were classified into four relationships - global warming and the obesity epidemic are correlated because of common drivers (n = 21); global warming influences the obesity epidemic (n = 13); the obesity epidemic influences global warming (n = 13); and global warming and the obesity epidemic influence each other (n = 3)...
October 4, 2017: Obesity Reviews: An Official Journal of the International Association for the Study of Obesity
https://www.readbyqxmd.com/read/28955734/chronic-high-fat-feeding-impairs-adaptive-induction-of-mitochondrial-fatty-acid-combustion-associated-proteins-in-brown-adipose-tissue-of-mice
#14
Takayuki Ohtomo, Kanako Ino, Ryota Miyashita, Maya Chigira, Masahiko Nakamura, Koji Someya, Niro Inaba, Mariko Fujita, Mitsuhiro Takagi, Junji Yamada
Since brown adipose tissue (BAT) is involved in thermogenesis using fatty acids as a fuel, BAT activation is a potential strategy for treating obesity and diabetes. However, whether BAT fatty acid combusting capacity is preserved in these conditions has remained unclear. We therefore evaluated expression levels of fatty acid oxidation-associated enzymes and uncoupling protein 1 (Ucp1) in BAT by western blot using a diet-induced obesity C57BL/6J mouse model. In C57BL/6J mice fed a high-fat diet (HFD) over 2-4 weeks, carnitine palmitoyltransferase 2 (Cpt2), acyl-CoA thioesterase (Acot) 2, Acot11 and Ucp1 levels were significantly increased compared with baseline and control low-fat diet (LFD)-fed mice...
July 2017: Biochemistry and Biophysics Reports
https://www.readbyqxmd.com/read/28928121/novel-pharmacological-probes-reveal-abhd5-as-a-locus-of-lipolysis-control-in-white-and-brown-adipocytes
#15
Elizabeth A Rondini, Ljiljana Mladenovic-Lucas, William R Roush, Geoff Halvorsen, Alex E Green, James G Granneman
Current knowledge regarding acute regulation of adipocyte lipolysis is largely based on receptor-mediated activation or inhibition of pathways that influence intracellular levels of cyclic AMP (cAMP), thereby affecting protein kinase A (PKA) activity. We recently identified synthetic ligands of α-β-hydrolase domain containing 5 (ABHD5) that directly activate adipose triglyceride lipase (ATGL) by dissociating ABHD5 from its inhibitory regulator, perilipin-1 (PLIN1). In the current study we used these novel ligands to determine the direct contribution of ABHD5 to various aspects of lipolysis control in white (3T3-L1) and brown adipocytes...
September 19, 2017: Journal of Pharmacology and Experimental Therapeutics
https://www.readbyqxmd.com/read/28925405/intermittent-energy-restriction-improves-weight-loss-efficiency-in-obese-men-the-matador-study
#16
N M Byrne, A Sainsbury, N A King, A P Hills, R E Wood
BACKGROUND/OBJECTIVES: The MATADOR (Minimising Adaptive Thermogenesis And Deactivating Obesity Rebound) study examined whether intermittent energy restriction (ER) improved weight loss efficiency compared with continuous ER and, if so, whether intermittent ER attenuated compensatory responses associated with ER. SUBJECTS/METHODS: Fifty-one men with obesity were randomised to 16 weeks of either: (1) continuous (CON), or (2) intermittent (INT) ER completed as 8 × 2-week blocks of ER alternating with 7 × 2-week blocks of energy balance (30 weeks total)...
August 17, 2017: International Journal of Obesity: Journal of the International Association for the Study of Obesity
https://www.readbyqxmd.com/read/28919880/non-mammalian-vertebrates-distinct-models-to-assess-the-role-of-ion-gradients-in-energy-expenditure
#17
REVIEW
Caroline E Geisler, Kyle P Kentch, Benjamin J Renquist
Animals store metabolic energy as electrochemical gradients. At least 50% of mammalian energy is expended to maintain electrochemical gradients across the inner mitochondrial membrane (H(+)), the sarcoplasmic reticulum (Ca(++)), and the plasma membrane (Na(+)/K(+)). The potential energy of these gradients can be used to perform work (e.g., transport molecules, stimulate contraction, and release hormones) or can be released as heat. Because ectothermic species adapt their body temperature to the environment, they are not constrained by energetic demands that are required to maintain a constant body temperature...
2017: Frontiers in Endocrinology
https://www.readbyqxmd.com/read/28877455/global-analysis-of-plasma-lipids-identifies-liver-derived-acylcarnitines-as-a-fuel-source-for-brown-fat-thermogenesis
#18
Judith Simcox, Gisela Geoghegan, John Alan Maschek, Claire L Bensard, Marzia Pasquali, Ren Miao, Sanghoon Lee, Lei Jiang, Ian Huck, Erin E Kershaw, Anthony J Donato, Udayan Apte, Nicola Longo, Jared Rutter, Renate Schreiber, Rudolf Zechner, James Cox, Claudio J Villanueva
Cold-induced thermogenesis is an energy-demanding process that protects endotherms against a reduction in ambient temperature. Using non-targeted liquid chromatography-mass spectrometry-based lipidomics, we identified elevated levels of plasma acylcarnitines in response to the cold. We found that the liver undergoes a metabolic switch to provide fuel for brown fat thermogenesis by producing acylcarnitines. Cold stimulates white adipocytes to release free fatty acids that activate the nuclear receptor HNF4α, which is required for acylcarnitine production in the liver and adaptive thermogenesis...
September 5, 2017: Cell Metabolism
https://www.readbyqxmd.com/read/28877451/the-liver-as-a-hub-in-thermogenesis
#19
Nada A Abumrad
Manipulating thermogenesis could increase energy expenditure and improve metabolism. Brown fat is a major site of nonshivering thermogenesis, but other tissues, notably muscle and liver, can contribute to cold adaptation. In this issue, Simcox et al. (2017) demonstrate in cold-exposed mice that liver-generated acylcarnitines are required to fuel thermogenesis.
September 5, 2017: Cell Metabolism
https://www.readbyqxmd.com/read/28831023/mild-cold-induced-thermogenesis-are-bat-and-skeletal-muscle-synergistic-partners
#20
Naresh C Bal, Santosh K Maurya, Sunil Pani, Chinmayee Sethy, Ananya Banerjee, Sarita Das, Srinivas Patnaik, Chanakya N Kundu
There are two well-described thermogenic sites; brown adipose tissue (BAT) and skeletal muscle, which utilize distinct mechanisms of heat production. In BAT, mitochondrial metabolism is the molecular basis of heat generation, while it serves only a secondary role in supplying energy for thermogenesis in muscle. Here, we wanted to document changes in mitochondrial ultrastructure in these two tissue types based upon adaptation to mild (16°C) and severe (4°C) cold in mice. When reared at thermoneutrality (29°C), mitochondria in both tissues were loosely packed with irregular cristae...
October 31, 2017: Bioscience Reports
keyword
keyword
14932
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"