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https://www.readbyqxmd.com/read/29774362/impact-of-a-pharmacy-led-smoking-cessation-clinic-in-a-dermatology-centre
#1
Hui Mei Cheng, Wen Chun Liu, Germaine Chua, Choon Fong Liew, Winnie Li, Winnie Choo, Hazel H Oon
INTRODUCTION: Cigarette smoking is a leading cause of morbidity and mortality, and has a deleterious effect on dermatological conditions, such as skin cancers, hidradenitis suppurativa and psoriasis. The study aimed to evaluate the efficacy of a pharmacist-led smoking cessation clinic in reducing cigarette smoking at a tertiary referral dermatology centre. We describe the impact of this clinic to provide guidance on how such a model could be further improved and implemented more widely...
May 18, 2018: Singapore Medical Journal
https://www.readbyqxmd.com/read/29769372/iglon5-mediated-neurodegeneration-is-a-differential-diagnosis-of-cns-whipple-disease
#2
Hugo Morales-Briceño, Belinda Cruse, Alessandro F Fois, Ming-Wei Lin, Jocelyn Jiang, Dev Banerjee, Ron Grunstein, Winny Varikatt, Michael Rodriguez, Claire Shepherd, Victor S C Fung
No abstract text is available yet for this article.
May 16, 2018: Neurology
https://www.readbyqxmd.com/read/29765301/the-additional-contribution-of-white-matter-hyperintensity-location-to-post-stroke-cognitive-impairment-insights-from-a-multiple-lesion-symptom-mapping-study
#3
Lei Zhao, Adrian Wong, Yishan Luo, Wenyan Liu, Winnie W C Chu, Jill M Abrigo, Ryan K L Lee, Vincent Mok, Lin Shi
White matter hyperintensities (WMH) are common in acute ischemic stroke patients. Although WMH volume has been reported to influence post-stroke cognition, it is still not clear whether WMH location, independent of acute ischemic lesion (AIL) volume and location, contributes to cognitive impairment after stroke. Here, we proposed a multiple-lesion symptom mapping model that considers both the presence of WMH and AIL to measure the additional contribution of WMH locations to post-stroke cognitive impairment...
2018: Frontiers in Neuroscience
https://www.readbyqxmd.com/read/29754821/a-post-transcriptional-feedback-mechanism-for-noise-suppression-and-fate-stabilization
#4
Maike M K Hansen, Winnie Y Wen, Elena Ingerman, Brandon S Razooky, Cassandra E Thompson, Roy D Dar, Charles W Chin, Michael L Simpson, Leor S Weinberger
Diverse biological systems utilize fluctuations ("noise") in gene expression to drive lineage-commitment decisions. However, once a commitment is made, noise becomes detrimental to reliable function, and the mechanisms enabling post-commitment noise suppression are unclear. Here, we find that architectural constraints on noise suppression are overcome to stabilize fate commitment. Using single-molecule and time-lapse imaging, we find that-after a noise-driven event-human immunodeficiency virus (HIV) strongly attenuates expression noise through a non-transcriptional negative-feedback circuit...
May 4, 2018: Cell
https://www.readbyqxmd.com/read/29754820/interfaces-of-malignant-and-immunologic-clonal-dynamics-in-ovarian-cancer
#5
Allen W Zhang, Andrew McPherson, Katy Milne, David R Kroeger, Phineas T Hamilton, Alex Miranda, Tyler Funnell, Nicole Little, Camila P E de Souza, Sonya Laan, Stacey LeDoux, Dawn R Cochrane, Jamie L P Lim, Winnie Yang, Andrew Roth, Maia A Smith, Julie Ho, Kane Tse, Thomas Zeng, Inna Shlafman, Michael R Mayo, Richard Moore, Henrik Failmezger, Andreas Heindl, Yi Kan Wang, Ali Bashashati, Diljot S Grewal, Scott D Brown, Daniel Lai, Adrian N C Wan, Cydney B Nielsen, Curtis Huebner, Basile Tessier-Cloutier, Michael S Anglesio, Alexandre Bouchard-Côté, Yinyin Yuan, Wyeth W Wasserman, C Blake Gilks, Anthony N Karnezis, Samuel Aparicio, Jessica N McAlpine, David G Huntsman, Robert A Holt, Brad H Nelson, Sohrab P Shah
High-grade serous ovarian cancer (HGSC) exhibits extensive malignant clonal diversity with widespread but non-random patterns of disease dissemination. We investigated whether local immune microenvironment factors shape tumor progression properties at the interface of tumor-infiltrating lymphocytes (TILs) and cancer cells. Through multi-region study of 212 samples from 38 patients with whole-genome sequencing, immunohistochemistry, histologic image analysis, gene expression profiling, and T and B cell receptor sequencing, we identified three immunologic subtypes across samples and extensive within-patient diversity...
May 7, 2018: Cell
https://www.readbyqxmd.com/read/29753677/multicenter-phase-1-2-application-of-adenovirus-specific-t-cells-in-high-risk-pediatric-patients-after-allogeneic-stem-cell-transplantation
#6
Winnie Ip, Juliana M F Silva, Hubert Gaspar, Arindam Mitra, Shreenal Patel, Kanchan Rao, Robert Chiesa, Persis Amrolia, Kimberly Gilmour, Gul Ahsan, Mary Slatter, Andrew R Gennery, Robert F Wynn, Paul Veys, Waseem Qasim
BACKGROUND: Adenovirus (ADV) reactivation can cause significant morbidity and mortality in children after allogeneic stem cell transplantation. Antiviral drugs can control viremia, but viral clearance requires recovery of cell-mediated immunity. METHOD: This study was an open-label phase 1/2 study to investigate the feasibility of generating donor-derived ADV-specific T cells (Cytovir ADV, Cell Medica) and to assess the safety of pre-emptive administration of ADV-specific T cells in high-risk pediatric patients after allogeneic hematopoietic stem cell transplantation (HSCT) to treat adenoviremia...
May 9, 2018: Cytotherapy
https://www.readbyqxmd.com/read/29745696/poetry-corner
#7
Eric P Charles
Presents a piece of poetry by A. A. Milne who is now best known as the author of the Winnie the Pooh (1926) book but was quite well reputed before its publication for his plays and his poetry, including collections such as When We Were Very Young (1924). The style of "Veridical Perception" will be familiar to any who have read his work. (PsycINFO Database Record
May 2018: History of Psychology
https://www.readbyqxmd.com/read/29743667/evaluation-of-pre-analytical-factors-affecting-plasma-dna-analysis
#8
Havell Markus, Tania Contente-Cuomo, Maria Farooq, Winnie S Liang, Mitesh J Borad, Shivan Sivakumar, Simon Gollins, Nhan L Tran, Harshil D Dhruv, Michael E Berens, Alan Bryce, Aleksandar Sekulic, Antoni Ribas, Jeffrey M Trent, Patricia M LoRusso, Muhammed Murtaza
Pre-analytical factors can significantly affect circulating cell-free DNA (cfDNA) analysis. However, there are few robust methods to rapidly assess sample quality and the impact of pre-analytical processing. To address this gap and to evaluate effects of DNA extraction methods and blood collection tubes on cfDNA yield and fragment size, we developed a multiplexed droplet digital PCR (ddPCR) assay with 5 short and 4 long amplicons targeting single copy genomic loci. Using this assay, we compared 7 cfDNA extraction kits and found cfDNA yield and fragment size vary significantly...
May 9, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29741439/healthcare-resource-use-and-cost-associated-with-varying-dosages-of-extended-corticosteroid-exposure-in-a-us-population
#9
J Bradford Rice, Alan G White, Michaela Johnson, Aneesha Wagh, Yimin Qin, Laura Bartels-Peculis, Gosia Ciepielewska, Winnie W Nelson
AIMS: Quantify healthcare resource use (HCRU) and costs associated with varying levels of corticosteroid exposure. MATERIALS AND METHODS: Patients with a diagnosis of selected autoimmune and inflammatory diseases between 1/1/2006 and 9/30/2015 ("study period") were selected from a de-identified, privately-insured claims database. Patients were stratified into four treatment cohorts based on the dosing and duration of continuous corticosteroid use following disease diagnosis: intermittent use with <60 days of corticosteroid use and ≥60 days of corticosteroid use with low (≤7...
May 9, 2018: Journal of Medical Economics
https://www.readbyqxmd.com/read/29741130/quantitative-characterization-of-the-relationship-between-levels-of-extended-corticosteroid-use-and-related-adverse-events-in-a-us-population
#10
J Bradford Rice, Alan G White, Michaela Johnson, Aneesha Wagh, Yimin Qin, Laura Bartels-Peculis, Gosia Ciepielewska, Winnie W Nelson
OBJECTIVE: This retrospective study assessed the incidence and timing of adverse events (AEs) among patients prescribed varying dose levels of corticosteroids in the US. METHODS: Patients with selected autoimmune or inflammatory disease diagnoses between 2006 and 2015 were identified from a privately-insured administrative database. Patients were stratified into treatment cohorts based on dosage and length of corticosteroid use: intermittent use with duration <60 days, and three extended use cohorts with duration ≥60 days at low (≤7...
May 9, 2018: Current Medical Research and Opinion
https://www.readbyqxmd.com/read/29739336/circular-rna-expression-and-regulatory-network-prediction-in-posterior-cingulate-astrocytes-in-elderly-subjects
#11
Shobana Sekar, Lori Cuyugan, Jonathan Adkins, Philipp Geiger, Winnie S Liang
BACKGROUND: Circular RNAs (circRNAs) are a novel class of endogenous, non-coding RNAs that form covalently closed continuous loops and that are both highly conserved and abundant in the mammalian brain. A role for circRNAs in sponging microRNAs (miRNAs) has been proposed, but the circRNA-miRNA-mRNA interaction networks in human brain cells have not been defined. Therefore, we identified circRNAs in RNA sequencing data previously generated from astrocytes microdissected from the posterior cingulate (PC) of Alzheimer's disease (AD) patients (N = 10) and healthy elderly controls (N = 10) using four circRNA prediction algorithms - CIRI, CIRCexplorer, find_circ and KNIFE...
May 9, 2018: BMC Genomics
https://www.readbyqxmd.com/read/29730457/anterior-posterior-length-discrepancy-of-the-spinal-column-in-adolescent-idiopathic-scoliosis-a-3d-ct-study
#12
Rob C Brink, Tom P C Schlösser, Marijn van Stralen, Koen L Vincken, Moyo C Kruyt, Steve C N Hui, Max A Viergever, Winnie C W Chu, Jack C Y Cheng, René M Castelein
BACKGROUND CONTEXT: One of the characteristics of reported observations in adolescent idiopathic scoliosis (AIS) is that the thoracic spine is longer anteriorly than posteriorly, more pronounced around the apex than the transitional zones. This reversal of the normal kyphotic anatomy of the thoracic spine is related to questions of etiopathogenesis of AIS. The changes in the anatomy of the anterior column have been described rather in detail, however, the role of the posterior spinal column and the laminae has so far not been elucidated...
May 3, 2018: Spine Journal: Official Journal of the North American Spine Society
https://www.readbyqxmd.com/read/29700350/mindfulness-based-stress-reduction-mbsr-or-psychoeducation-for-the-reduction-of-menopausal-symptoms-a-randomized-controlled-clinical-trial
#13
Carmen Wong, Benjamin Hon-Kei Yip, Ting Gao, Kitty Yu Yuk Lam, Doris Mei Sum Woo, Annie Lai King Yip, Chloe Yu Chin, Winnie Pui Yin Tang, Mandy Mun Tse Choy, Katrina Wai Key Tsang, Suzanne C Ho, Helen Shuk Wah Ma, Samuel Yeung Shan Wong
Psychological and behavioural interventions may be effective in reducing menopause-related symptoms. This randomized controlled trial aimed to evaluate the effectiveness of Mindfulness-based Stress Reduction (MBSR) in reducing menopause-related symptoms by comparing with an active control group, the menopause education control (MEC). Symptomatic peri-menopausal and post-menopausal women with mild to moderate symptoms were recruited. The primary outcome was overall menopausal symptoms measured by modified Greene Climacteric Scale (GCS)...
April 26, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29695335/winnie-mpanju-shumbusho-leader-in-the-fight-against-malaria
#14
John Zarocostas
No abstract text is available yet for this article.
April 21, 2018: Lancet
https://www.readbyqxmd.com/read/29695191/high-glucose-inhibits-neural-stem-cell-differentiation-through-oxidative-stress-and-endoplasmic-reticulum-stress
#15
Xi Chen, Wei-Bin Shen, Penghua Yang, Daoyin Dong, Winny Sun, Peixin Yang
Maternal diabetes induces neural tube defects by suppressing neurogenesis in the developing neuroepithelium. Our recent study further revealed that high glucose inhibited embryonic stem cell differentiation into neural lineage cells. However, the mechanism whereby high glucose suppresses neural differentiation is unclear. To investigate whether high glucose-induced oxidative stress and endoplasmic reticulum stress (ER stress) lead to the inhibition of neural differentiation, the effect of high glucose on neural stem cell (the C17...
April 26, 2018: Stem Cells and Development
https://www.readbyqxmd.com/read/29690541/colorectal-vaginal-fistulas-imaging-and-novel-interventional-treatment-modalities
#16
REVIEW
M-Grace Knuttinen, Johnny Yi, Paul Magtibay, Christina T Miller, Sadeer Alzubaidi, Sailendra Naidu, Rahmi Oklu, J Scott Kriegshauser, Winnie A Mar
Colovaginal and/or rectovaginal fistulas cause significant and distressing symptoms, including vaginitis, passage of flatus/feces through the vagina, and painful skin excoriation. These fistulas can be a challenging condition to treat. Although most fistulas can be treated with surgical repair, for those patients who are not operative candidates, limited options remain. As minimally-invasive interventional techniques have evolved, the possibility of fistula occlusion has enriched the therapeutic armamentarium for the treatment of these complex patients...
April 22, 2018: Journal of Clinical Medicine
https://www.readbyqxmd.com/read/29689443/the-effect-of-time-on-emg-classification-of-hand-motions-in-able-bodied-and-transradial-amputees
#17
Asim Waris, Imran Khan Niazi, Mohsin Jamil, Omer Gilani, Kevin Englehart, Winnie Jensen, Muhammad Shafique, Ernest Nlandu Kamavuako
While several studies have demonstrated the short-term performance of pattern recognition systems, long-term investigations are very limited. In this study, we investigated changes in classification performance over time. Ten able-bodied individuals and six amputees took part in this study. EMG signals were recorded concurrently from surface and intramuscular electrodes, with intramuscular electrodes kept in the muscles for seven days. Seven hand motions were evaluated daily using linear discriminant analysis and the classification error quantified within (WCE) and between (BCE) days...
April 17, 2018: Journal of Electromyography and Kinesiology
https://www.readbyqxmd.com/read/29681968/quercetin-potentiates-the-ngf-induced-effects-in-cultured-pc-12-cells-identification-by-herbochips-showing-a-binding-with-ngf
#18
Gallant K L Chan, Winnie W H Hu, Zoey X Zheng, M Huang, Yan X Y Lin, Caroline Y Wang, Amy G W Gong, X Y Yang, Karl W K Tsim, Tina T X Dong
Dementia is a persistent disorder of the mental processes and is strongly related to depression. However, the performance of current antidepression medicine is far from satisfactory. Herbal extract provides an excellent source to identify compounds for possible drug development against depression. Here, HerboChips were employed to search herbal compounds that could bind nerve growth factor (NGF). By screening over 500 types of herbal extracts, the water extract of Ginkgo Folium, the leaf of Ginkgo biloba , showed a strong binding to NGF...
2018: Evidence-based Complementary and Alternative Medicine: ECAM
https://www.readbyqxmd.com/read/29675835/monofunctional-and-telechelic-polyethylenes-carrying-phosphonic-acid-end-groups
#19
Winnie Nzahou Ottou, Sébastien Norsic, Franck D'Agosto, Christophe Boisson
Monofunctional or telechelic polyethylenes (PEs) carrying phosphonic acid end groups are obtained from functional PE produced by catalyzed chain growth (CCG) on magnesium. CCG is first used to produce iodo-end-functionalized PE (PE-I) that is efficiently turned into phosphonate end-functionalized PE (PE-P(O)(OEt)2 ) in the presence of triethylphosphite through the Michaelis-Arbuzov reaction. A simple treatment of the resulting PE-P(O)(OEt)2 with bromotrimethylsilane leads to the targeted phosphonic acid end-functionalized PE (PE-P(O)(OH)2 ) for the first time...
April 20, 2018: Macromolecular Rapid Communications
https://www.readbyqxmd.com/read/29675450/engineered-human-gastrointestinal-cultures-to-study-the-microbiome-and-infectious-diseases
#20
REVIEW
Sarah E Blutt, Sue E Crawford, Sasirekha Ramani, Winnie Y Zou, Mary K Estes
New models to study the intestine are key to understanding intestinal diseases and developing novel treatments. Intestinal organ-like culture systems (organoids and enteroids) have substantially advanced the study of the human gastrointestinal tract. Stem cell-derived cultures produce self-organizing structures that contain the multiple differentiated intestinal epithelial cell types including enterocytes, goblet, Paneth, and enteroendocrine cells. Understanding host-microbial interactions is one area in which these cultures are expediting major advancements...
March 2018: Cellular and Molecular Gastroenterology and Hepatology
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