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https://www.readbyqxmd.com/read/28230048/differential-regulation-of-the-epr3-receptor-coordinates-membrane-restricted-rhizobial-colonization-of-root-nodule-primordia
#1
Yasuyuki Kawaharada, Mette W Nielsen, Simon Kelly, Euan K James, Kasper R Andersen, Sheena R Rasmussen, Winnie Füchtbauer, Lene H Madsen, Anne B Heckmann, Simona Radutoiu, Jens Stougaard
In Lotus japonicus, a LysM receptor kinase, EPR3, distinguishes compatible and incompatible rhizobial exopolysaccharides at the epidermis. However, the role of this recognition system in bacterial colonization of the root interior is unknown. Here we show that EPR3 advances the intracellular infection mechanism that mediates infection thread invasion of the root cortex and nodule primordia. At the cellular level, Epr3 expression delineates progression of infection threads into nodule primordia and cortical infection thread formation is impaired in epr3 mutants...
February 23, 2017: Nature Communications
https://www.readbyqxmd.com/read/28227520/cross-frequency-information-transfer-from-eeg-to-emg-in-grasping
#2
Winnie K Y So, Lingling Yang, Beth Jelfs, Qi She, Savio W H Wong, Joseph N Mak, Rosa H M Chan, Winnie K Y So, Lingling Yang, Beth Jelfs, Qi She, Savio W H Wong, Joseph N Mak, Rosa H M Chan, Rosa H M Chan, Beth Jelfs, Savio W H Wong, Lingling Yang, Qi She, Joseph N Mak, Winnie K Y So
This paper presents an investigation into the cortico-muscular relationship during a grasping task by evaluating the information transfer between EEG and EMG signals. Information transfer was computed via a non-linear model-free measure, transfer entropy (TE). To examine the cross-frequency interaction, TEs were computed after the times series were decomposed into various frequency ranges via wavelet transform. Our results demonstrate the capability of TE to capture the direct interaction between EEG and EMG...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28226817/effective-connectivity-matrix-for-neural-ensembles
#3
Qi She, Winnie K Y So, Rosa H M Chan, Qi She, Winnie K Y So, Rosa H M Chan, Rosa H M Chan, Qi She, Winnie K Y So
In this paper, we present an efficient framework to study the directional interactions within the multiple-input multiple-output (MIMO) biological neural network from spiketrain data. We used an efficient generalized linear model (GLM) with Laguerre basis functions to model a MIMO neural system, and developed an Effective Connectivity Matrix (ECM) to visualize excitatory and inhibitory connections within the neural network. A new causality representation was developed based on system dynamics. Statistical test was applied to identify the significance of the measured causality...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28213814/translation-and-validation-of-tools-for-assessing-health-related-quality-of-life-and-male-sexual-function-in-hong-kong-chinese-patients-during-transitional-cancer-survivorship
#4
Ka Ming Chow, Carmen W H Chan, Winnie K W So, Doris Y P Leung
No abstract text is available yet for this article.
February 17, 2017: Supportive Care in Cancer: Official Journal of the Multinational Association of Supportive Care in Cancer
https://www.readbyqxmd.com/read/28211128/staged-intraperitoneal-brachytherapy-and-hyperthermic-intraperitoneal-chemotherapy-in-an-adolescent-novel-anesthetic-challenges-for-pediatric-anesthetists
#5
Andrew D Weatherall, Tristan R Bennett, Mark Lovell, Winnie Fung, Jonathan de Lima
Newer techniques that have found a place in cancer management in adults are offered far less commonly in pediatric patients. We present a case of a patient with recurrent Wilms' tumor managed with a novel combination of cytoreductive surgery, intraperitoneal brachytherapy, and subsequent hyperthermic intraperitoneal chemotherapy. Each stage presents challenges that the pediatric anesthetist is unlikely to have faced before. Such cases require flexibility and thorough planning to manage the combination of major surgery, remote anesthesia with brachytherapy and hyperthermic chemotherapy with its potential for metabolic derangement, significant fluid shifts, analgesic care, and potential exposure of staff to cytotoxic agents...
February 17, 2017: Paediatric Anaesthesia
https://www.readbyqxmd.com/read/28209771/hearing-loss-in-children-with-asymptomatic-congenital-cytomegalovirus-infection
#6
Tatiana M Lanzieri, Winnie Chung, Marily Flores, Peggy Blum, A Chantal Caviness, Stephanie R Bialek, Scott D Grosse, Jerry A Miller, Gail Demmler-Harrison
OBJECTIVES: To assess the prevalence, characteristics, and risk of sensorineural hearing loss (SNHL) in children with congenital cytomegalovirus infection identified through hospital-based newborn screening who were asymptomatic at birth compared with uninfected children. METHODS: We included 92 case-patients and 51 controls assessed by using auditory brainstem response and behavioral audiometry. We used Kaplan-Meier survival analysis to estimate the prevalence of SNHL, defined as ≥25 dB hearing level at any frequency and Cox proportional hazards regression analyses to compare SNHL risk between groups...
February 16, 2017: Pediatrics
https://www.readbyqxmd.com/read/28205177/measuring-activity-of-cholesterol-synthesis-enzymes-using-gas-chromatography-mass-spectrometry
#7
Anika V Prabhu, Winnie Luu, Andrew J Brown
The development of gas chromatography/mass spectrometry (GC/MS) technology has improved the ease and efficiency with which sterols in biological samples can be analyzed. Its advantages include that it needs only a small amount of sample, a short analysis time, and has enhanced specificity over traditional methods. Furthermore, a major benefit is its nonselective properties, which means that a complete scan of the sample will display the relative abundance of every sterol in the sample. This property has made it possible to define the abnormal, but distinctive, sterol profiles in a number of inborn errors of cholesterol synthesis...
2017: Methods in Molecular Biology
https://www.readbyqxmd.com/read/28205165/manipulating-cholesterol-status-within-cells
#8
Winnie Luu, Ingrid C Gelissen, Andrew J Brown
Cellular cholesterol levels are intricately controlled to maintain homeostasis. Here, we describe ways in which cellular cholesterol status can be manipulated for the study of cholesterol homeostasis, including sterol starvation (by culturing cells in lipoprotein-deficient serum and pretreating/treating with the cholesterol-lowering drug, statin) and sterol enrichment (using cholesterol complexed to cyclodextrin, and low-density lipoprotein). We also describe how to prepare lipoprotein-deficient serum and complex cholesterol to cyclodextrin...
2017: Methods in Molecular Biology
https://www.readbyqxmd.com/read/28185725/synthesis-and-in-vitro-evaluation-of-5-substituted-benzovesamicol-analogs-containing-n-substituted-amides-as-potential-positron-emission-tomography-tracers-for-the-vesicular-acetylcholine-transporter
#9
Sara Roslin, Maria De Rosa, Winnie Deuther-Conrad, Jonas Eriksson, Luke R Odell, Gunnar Antoni, Peter Brust, Mats Larhed
Herein, new ligands for the vesicular acetylcholine transporter (VAChT), based on a benzovesamicol scaffold, are presented. VAChT is acknowledged as a marker for cholinergic neurons and a positron emission tomography tracer for VAChT could serve as a tool for quantitative analysis of cholinergic neuronal density. With an easily accessible triflate precursor, aminocarbonylations were utilized to evaluate the chemical space around the C5 position on the tetrahydronaphthol ring. Synthesized ligands were evaluated for their affinity and selectivity for VAChT...
January 25, 2017: Bioorganic & Medicinal Chemistry
https://www.readbyqxmd.com/read/28167942/distinct-cytokine-and-chemokine-profiles-in-autism-spectrum-disorders
#10
Yvonne M Y Han, Winnie K Y Cheung, Chun Kwok Wong, Sophia L Sze, Timmy W S Cheng, Michael K Yeung, Agnes S Chan
Previous studies have shown that immunological factors are involved in the pathogenesis of autism spectrum disorders (ASDs). However, this research has been conducted almost exclusively in Western contexts, and only a handful of studies on immune measures have been conducted in Asian populations, such as Chinese populations. The present study examined whether immunological abnormalities are associated with cognitive deficits and problem behaviors in Chinese children with ASD and whether these children show different immunological profiles...
2017: Frontiers in Immunology
https://www.readbyqxmd.com/read/28166498/real-time-interactive-tree-animation
#11
Ed Quigley, Yue Yu, Jingwei Huang, Winnie Lin, Ronald Fedkiw
We present a novel method for posing and animating botanical tree models interactively in real time. Unlike other state of the art methods which tend to produce trees that are overly flexible, bending and deforming as if they were underwater plants, our approach allows for arbitrarily high stiffness while still maintaining real-time frame rates without spurious artifacts, even on quite large trees with over ten thousand branches. This is accomplished by using an articulated rigid body model with as-stiff-as-desired rotational springs in conjunction with our newly proposed simulation technique, which is motivated both by position based dynamics and the typical O(N) algorithms for articulated rigid bodies...
January 30, 2017: IEEE Transactions on Visualization and Computer Graphics
https://www.readbyqxmd.com/read/28157792/ultrasound-guided-costoclavicular-brachial-plexus-block-sonoanatomy-technique-and-block-dynamics
#12
Jia Wei Li, Banchobporn Songthamwat, Winnie Samy, Xavier Sala-Blanch, Manoj Kumar Karmakar
BACKGROUND AND OBJECTIVES: This study aimed to describe in detail the relevant sonoanatomy, technique, and block dynamics of an ultrasound-guided costoclavicular brachial plexus block (BPB). METHODS: Thirty patients scheduled for hand or forearm surgery under a BPB underwent transverse ultrasound imaging of the medial infraclavicular fossa to identify the cords of the brachial plexus at the costoclavicular space (CCS). An ultrasound-guided BPB was then performed at the CCS with 20 mL of 0...
March 2017: Regional Anesthesia and Pain Medicine
https://www.readbyqxmd.com/read/28156484/molecular-tumor-profiling-ordering-trends-in-cancer-patients
#13
Winnie S Wang, Warren Yau, Chelsea Hagmann, Carolyn Revta, Janet M Armstrong, Eric Roeland
: 165 Background: Molecular tumor profiling may provide information as to whether to initiate or not initiate a targeted therapy. As to the timing of when the tumor profiling is ordered relative to date of diagnosis, date of death, and palliative care (PC) consultations are unknown. The primary objective of this study was to examine molecular tumor profiling ordering trends in the course of cancer illness. METHODS: A preliminary, retrospective chart review was conducted in a cohort of patients with a confirmed diagnosis of cancer at an academic, NCI-designated comprehensive cancer center...
October 9, 2016: Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology
https://www.readbyqxmd.com/read/28143554/ethical-challenges-related-to-assistive-product-access-for-older-adults-and-adults-living-with-a-disability-a-scoping-review-protocol
#14
Winnie Sun, Michael G Wilson, Daphne Schreiber, Rosalie H Wang
BACKGROUND: Despite the surge of research and development in assistive products for older adults and/or people living with disabilities, policies on access and procurement have lagged in responding to the growing demand from users. Developing policies to address these concerns require an understanding of the ethical challenges underlying approaches for providing assistive products. The purpose of this scoping review is to identify and map the literature pertaining to ethical challenges related to assistive product access and procurement to inform policy development...
February 1, 2017: Systematic Reviews
https://www.readbyqxmd.com/read/28140608/rosai-dorfman-disease-manifestations-outside-of-the-head-and-neck
#15
Winnie A Mar, Jonathan H Yu, Martha Gracia Knuttinen, Jeanne M Horowitz, Odile David, Andrew Wilbur, Christine O Menias
OBJECTIVE: Rosai-Dorfman disease (RDD) is an uncommon benign histiocytic disorder. Extranodal involvement occurs in 43% and most commonly involves the head and neck, skin, and bones. We review less common imaging findings outside the head and neck. CONCLUSION: The imaging manifestations of RDD overlap with a variety of neoplastic and nonneoplastic conditions. Confirmation of an RDD diagnosis is based on specific histologic features. Radiologic assessment is used to rule out multifocality on initial workup and to evaluate treatment response...
January 31, 2017: AJR. American Journal of Roentgenology
https://www.readbyqxmd.com/read/28125820/transarterial-chemo-embolisation-of-hepatocellular-carcinoma-impact-of-liver-function-and-vascular-invasion
#16
Imam Waked, Sarah Berhane, Hidenori Toyoda, Stephen L Chan, Nicholas Stern, Daniel Palmer, Toshifumi Tada, Winnie Yeo, Frankie Mo, Dominik Bettinger, Martha M Kirstein, Mercedes Iñarrairaegui, Asmaa Gomaa, Arndt Vogel, Tim Meyer, Bruno Sangro, Paul Lai, Takashi Kumada, Philip J Johnson
BACKGROUND: Transarterial chemo-embolisation (TACE) is recommended for patients with BCLC intermediate stage hepatocellular carcinoma (stage B), particularly in patients with good underlying liver function and minimal symptoms. The hepatoma arterial embolisation prognostic (HAP) score combines measures of liver function and tumour-related factors to offer a simple prognostic scoring system. The Albumin-Bilirubin (ALBI) grade permits assessment of the impact of liver function on survival...
February 14, 2017: British Journal of Cancer
https://www.readbyqxmd.com/read/28120003/pet-imaging-of-%C3%AE-7-nicotinic-acetylcholine-receptors-a-comparative-study-of-18-f-asem-and-18-f-dbt-10-in-nonhuman-primates-and-further-evaluation-of-18-f-asem-in-humans
#17
Ansel T Hillmer, Songye Li, Ming-Qiang Zheng, Matthias Scheunemann, Shu-Fei Lin, Nabeel Nabulsi, Daniel Holden, Richard Pracitto, David Labaree, Jim Ropchan, Rodrigo Teodoro, Winnie Deuther-Conrad, Irina Esterlis, Kelly P Cosgrove, Peter Brust, Richard E Carson, Yiyun Huang
PURPOSE: The α7 nicotinic acetylcholine receptor (nAChR) is implicated in many neuropsychiatric disorders, making it an important target for positron emission tomography (PET) imaging. The first aim of this work was to compare two α7 nAChRs PET radioligands, [(18)F]ASEM (3-(1,4-diazabicyclo[3.2.2]nonan-4-yl)-6-([(18)F]fluorodibenzo[b,d]thiophene 5,5-dioxide) and [(18)F]DBT-10 (7-(1,4-diazabicyclo[3.2.2]nonan-4-yl)-2-([(18)F]fluorodibenzo[b,d]thiophene 5,5-dioxide), in nonhuman primates...
January 24, 2017: European Journal of Nuclear Medicine and Molecular Imaging
https://www.readbyqxmd.com/read/28117690/body-weight-status-and-dietary-intakes-of-urban-malay-primary-school-children-evidence-from-the-family-diet-study
#18
Wai Yew Yang, Tracy Burrows, Lesley MacDonald-Wicks, Lauren T Williams, Clare E Collins, Winnie Siew Swee Chee, Kim Colyvas
Malaysia is experiencing a rise in the prevalence of childhood obesity. Evidence for the relationship between dietary intake and body weight among Malaysian children is limited, with the impact of energy intake misreporting rarely being considered. This paper describes the dietary intakes of urban Malay children in comparison to national recommendations and by weight status. This cross-sectional Family Diet Study (n = 236) was conducted in five national primary schools in Malaysia (August 2013-October 2014)...
January 20, 2017: Children
https://www.readbyqxmd.com/read/28116329/cftr-founder-mutation-causes-protein-trafficking-defects-in-chinese-patients-with-cystic-fibrosis
#19
Gordon K C Leung, Dingge Ying, Christopher C Y Mak, Xin-Ying Chen, Weiyi Xu, Kit-San Yeung, Wai-Lap Wong, Yoyo W Y Chu, Gary T K Mok, Christy S K Chau, Jenna McLuskey, Winnie P T Ong, Huey-Yin Leong, Kelvin Y K Chan, Wanling Yang, Jeng-Haur Chen, Albert M Li, Pak C Sham, Yu-Lung Lau, Brian H Y Chung, So-Lun Lee
BACKGROUND: Cystic fibrosis (CF) is a rare condition in Asians. Since 1985, only about 30 Chinese patients have been reported with molecular confirmation. METHOD: Using our in-house next-generation sequencing (NGS) pipeline for childhood bronchiectasis, we identified disease-causing CFTR mutations in CF patients in Hong Kong. After identifying p.I1023R in multiple patients, haplotype analysis was performed with genome-wide microarray to ascertain the likelihood of this being a founder mutation...
January 2017: Molecular Genetics & Genomic Medicine
https://www.readbyqxmd.com/read/28115613/synchronization-patterns-from-network-motifs-to-hierarchical-networks
#20
Sanjukta Krishnagopal, Judith Lehnert, Winnie Poel, Anna Zakharova, Eckehard Schöll
We investigate complex synchronization patterns such as cluster synchronization and partial amplitude death in networks of coupled Stuart-Landau oscillators with fractal connectivities. The study of fractal or self-similar topology is motivated by the network of neurons in the brain. This fractal property is well represented in hierarchical networks, for which we present three different models. In addition, we introduce an analytical eigensolution method and provide a comprehensive picture of the interplay of network topology and the corresponding network dynamics, thus allowing us to predict the dynamics of arbitrarily large hierarchical networks simply by analysing small network motifs...
March 6, 2017: Philosophical Transactions. Series A, Mathematical, Physical, and Engineering Sciences
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