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https://www.readbyqxmd.com/read/28728497/the-significance-of-benefit-perceptions-for-the-ethics-of-hiv-research-involving-adolescents-in-kenya
#1
Stuart Rennie, Allison K Groves, Denise Dion Hallfors, Bonita J Iritani, Fredrick S Odongo, Winnie K Luseno
Assessment of benefits is traditionally regarded as crucial to the ethical evaluation of research involving human participants. We conducted focus group discussions (FGDs) with health and other professionals engaged with adolescents, caregivers/parents, and adolescents in Siaya County, Kenya, to solicit opinions about appropriate ways of conducting HIV research with adolescents. Our data revealed that many focus group participants have a profoundly positive conception of participation in health research, including studies conferring seemingly few benefits...
July 1, 2017: Journal of Empirical Research on Human Research Ethics: JERHRE
https://www.readbyqxmd.com/read/28720039/the-revamp-trial-to-evaluate-hiv-resistance-testing-in-sub-saharan-africa-a-case-study-in-clinical-trial-design-in-resource-limited-settings-to-optimize-effectiveness-and-cost-effectiveness-estimates
#2
Mark J Siedner, Mwebesa B Bwana, Mahomed-Yunus S Moosa, Michelle Paul, Selvan Pillay, Suzanne McCluskey, Isaac Aturinda, Kevin Ard, Winnie Muyindike, Pravikrishnen Moodley, Jaysingh Brijkumar, Tamlyn Rautenberg, Gavin George, Brent Johnson, Rajesh T Gandhi, Henry Sunpath, Vincent C Marconi
BACKGROUND: In sub-Saharan Africa, rates of sustained HIV virologic suppression remain below international goals. HIV resistance testing, while common in resource-rich settings, has not gained traction due to concerns about cost and sustainability. OBJECTIVE: We designed a randomized clinical trial to determine the feasibility, effectiveness, and cost-effectiveness of routine HIV resistance testing in sub-Saharan Africa. APPROACH: We describe challenges common to intervention studies in resource-limited settings, and strategies used to address them, including: (1) optimizing generalizability and cost-effectiveness estimates to promote transition from study results to policy; (2) minimizing bias due to patient attrition; and (3) addressing ethical issues related to enrollment of pregnant women...
July 18, 2017: HIV Clinical Trials
https://www.readbyqxmd.com/read/28719370/simple-preparation-of-timolol-0-5-gel-from-eye-drop-solution-for-superficial-infantile-hemangiomas
#3
Winnie Choo
The discovery of beta-adrenergic blocker effects on infantile hemangiomas has affected the choice of treatment in recent years. Oral propranolol is effective in treating infantile hemangiomas, but the risk of systemic side effects remains a concern. Data from literature review reported positive clinical outcomes with no major adverse effects observed in children using topical beta-blocker such as timolol maleate. Topical application of timolol eye drop has been mentioned in few studies, most of which reported that the solution cannot stay on the site of application due to its fluidity...
July 2017: International Journal of Pharmaceutical Compounding
https://www.readbyqxmd.com/read/28716927/nuclear-genomes-distinguish-cryptic-species-suggested-by-their-dna-barcodes-and-ecology
#4
Daniel H Janzen, John M Burns, Qian Cong, Winnie Hallwachs, Tanya Dapkey, Ramya Manjunath, Mehrdad Hajibabaei, Paul D N Hebert, Nick V Grishin
DNA sequencing brings another dimension to exploration of biodiversity, and large-scale mitochondrial DNA cytochrome oxidase I barcoding has exposed many potential new cryptic species. Here, we add complete nuclear genome sequencing to DNA barcoding, ecological distribution, natural history, and subtleties of adult color pattern and size to show that a widespread neotropical skipper butterfly known as Udranomia kikkawai (Weeks) comprises three different species in Costa Rica. Full-length barcodes obtained from all three century-old Venezuelan syntypes of U...
July 17, 2017: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/28716883/role-of-the-%C3%AE-common-%C3%AE-c-family-of-cytokines-in-health-and-disease
#5
Timothy R Hercus, Winnie L T Kan, Sophie E Broughton, Denis Tvorogov, Hayley S Ramshaw, Jarrod J Sandow, Tracy L Nero, Urmi Dhagat, Emma J Thompson, Karen S Cheung Tung Shing, Duncan R McKenzie, Nicholas J Wilson, Catherine M Owczarek, Gino Vairo, Andrew D Nash, Vinay Tergaonkar, Timothy Hughes, Paul G Ekert, Michael S Samuel, Claudine S Bonder, Michele A Grimbaldeston, Michael W Parker, Angel F Lopez
The β common ([βc]/CD131) family of cytokines comprises granulocyte macrophage colony-stimulating factor (GM-CSF), interleukin (IL)-3, and IL-5, all of which use βc as their key signaling receptor subunit. This is a prototypic signaling subunit-sharing cytokine family that has unveiled many biological paradigms and structural principles applicable to the IL-2, IL-4, and IL-6 receptor families, all of which also share one or more signaling subunits. Originally identified for their functions in the hematopoietic system, the βc cytokines are now known to be truly pleiotropic, impacting on multiple cell types, organs, and biological systems, and thereby controlling the balance between health and disease...
July 17, 2017: Cold Spring Harbor Perspectives in Biology
https://www.readbyqxmd.com/read/28715041/diagnostic-single-gene-analyses-beyond-sanger-economic-high-throughput-sequencing-of-small-genes-involved-in-congenital-coagulation-and-platelet-disorders
#6
Juliane Najm, Matthias Rath, Winnie Schröder, Ute Felbor
Molecular testing of congenital coagulation and platelet disorders offers confirmation of clinical diagnoses, supports genetic counselling, and enables predictive and prenatal diagnosis. In some cases, genotype-phenotype correlations are important for predicting the clinical course of the disease and adaptation of individualized therapy. Until recently, genotyping has been mainly performed by Sanger sequencing. While next generation sequencing (NGS) enables the parallel analysis of multiple genes, the cost-value ratio of custom-made panels can be unfavorable for analyses of specific small genes...
July 17, 2017: Hämostaseologie
https://www.readbyqxmd.com/read/28713255/the-impact-of-aerobic-exercise-on-fronto-parietal-network-connectivity-and-its-relation-to-mobility-an-exploratory-analysis-of-a-6-month-randomized-controlled-trial
#7
Chun L Hsu, John R Best, Shirley Wang, Michelle W Voss, Robin G Y Hsiung, Michelle Munkacsy, Winnie Cheung, Todd C Handy, Teresa Liu-Ambrose
Impaired mobility is a major concern for older adults and has significant consequences. While the widely accepted belief is that improved physical function underlies the effectiveness of targeted exercise training in improving mobility and reducing falls, recent evidence suggests cognitive and neural benefits gained through exercise may also play an important role in promoting mobility. However, the underlying neural mechanisms of this relationship are currently unclear. Thus, we hypothesize that 6 months of progressive aerobic exercise training would alter frontoparietal network (FPN) connectivity during a motor task among older adults with mild subcortical ischemic vascular cognitive impairment (SIVCI)-and exercise-induced changes in FPN connectivity would correlate with changes in mobility...
2017: Frontiers in Human Neuroscience
https://www.readbyqxmd.com/read/28704645/meta-analysis-and-systematic-review-of-studies-on-the-effectiveness-of%C3%A2-hiv-stigma-reduction-programs
#8
REVIEW
Winnie W S Mak, Phoenix K H Mo, Gloria Y K Ma, Maggie Y Y Lam
OBJECTIVE: The present study conducted a meta-analysis and systematic review on studies evaluating the effectiveness of stigma reduction programs in improving knowledge and reducing negative attitudes towards people living with HIV (PLHIV). RESULTS: Meta-analysis (k = 42 studies) found significant and small effect sizes in the improvement of the participants' knowledge of HIV/AIDS from interventions with (Cohen's d = 0.48, 95% CI [0.30, 0.66]) and without control groups (Cohen's d = 0...
July 1, 2017: Social Science & Medicine
https://www.readbyqxmd.com/read/28700589/ank1-is-up-regulated-in-laser-captured-microglia-in-alzheimer-s-brain-the-importance-of-addressing-cellular-heterogeneity
#9
Diego Mastroeni, Shobana Sekar, Jennifer Nolz, Elaine Delvaux, Katie Lunnon, Jonathan Mill, Winnie S Liang, Paul D Coleman
Recent epigenetic association studies have identified a new gene, ANK1, in the pathogenesis of Alzheimer's disease (AD). Although strong associations were observed, brain homogenates were used to generate the data, introducing complications because of the range of cell types analyzed. In order to address the issue of cellular heterogeneity in homogenate samples we isolated microglial, astrocytes and neurons by laser capture microdissection from CA1 of hippocampus in the same individuals with a clinical and pathological diagnosis of AD and matched control cases...
2017: PloS One
https://www.readbyqxmd.com/read/28699440/-nurse-cared-for-me-as-a-patient-and-inspired-me-as-a-colleague
#10
(no author information available yet)
I have worked at the same trust as Winnie Nugent and have also been her patient. For many years she has helped me as a patient at the young onset urology service at Guy's Hospital in London. She has regularly gone above and beyond what I could ever have expected of her.
July 12, 2017: Nursing Standard
https://www.readbyqxmd.com/read/28689189/early-hearing-detection-and-vocabulary-of-children-with-hearing-loss
#11
Christine Yoshinaga-Itano, Allison L Sedey, Mallene Wiggin, Winnie Chung
BACKGROUND AND OBJECTIVES: To date, no studies have examined vocabulary outcomes of children meeting all 3 components of the Early Hearing Detection and Intervention (EHDI) guidelines (hearing screening by 1 month, diagnosis of hearing loss by 3 months, and intervention by 6 months of age). The primary purpose of the current study was to examine the impact of the current EHDI 1-3-6 policy on vocabulary outcomes across a wide geographic area. A secondary goal was to confirm the impact of other demographic variables previously reported to be related to language outcomes...
July 8, 2017: Pediatrics
https://www.readbyqxmd.com/read/28685277/ko-pamoja-the-feasibility-of-a-lay-health-educator-led-breast-and-cervical-screening-program-for-black-women-in-ontario-canada-short-report
#12
Aisha Lofters, Ankur Jain, Winnie Siu, Meghan Kyte, Nakia Lee-Foon, Fran Scott, Onye Nnorom
BACKGROUND: Effective strategies are needed to actively encourage Black women in Canada to adhere to breast and cervical cancer screening and follow-up. In this study, we describe "Ko-Pamoja," a pilot peer education program for breast and cervical cancer screening targeted specifically at Black women in Toronto, Canada. METHODS: We used an Afrocentric lens to design the program, whose purpose was to increase awareness of cancer susceptibility and the benefits of screening for breast and cervical cancer for Black women...
July 6, 2017: Cancer Causes & Control: CCC
https://www.readbyqxmd.com/read/28678623/economic-burden-of-sarcoidosis-in-a-commercially-insured-population-in-the-united-states
#13
J Bradford Rice, Alan White, Andrea Lopez, Alexandra Conway, Aneesha Wagh, Winnie W Nelson, Michael Philbin, George J Wan
BACKGROUND: Sarcoidosis is a multisystem inflammatory disorder characterized by the presence of noncaseating granulomas in involved organs. Patients with sarcoidosis have a reduced quality of life and are at an increased risk for several comorbidities. Little is known about the direct and indirect cost of sarcoidosis following the initial diagnosis. AIMS: To provide an estimate of the healthcare resource utilization (HCRU) and costs borne by commercial payers for sarcoidosis patients in the US...
July 5, 2017: Journal of Medical Economics
https://www.readbyqxmd.com/read/28673061/the-risk-of-upper-urinary-tract-involvement-in-patients-with-ketamine-associated-uropathy
#14
Chi-Hang Yee, Jeremy Yuen-Chun Teoh, Pui-Tak Lai, Vivian Yee-Fong Leung, Winnie Chiu-Wing Chu, Wai-Man Lee, Yuk-Him Tam, Chi-Fai Ng
PURPOSE: The aims of this study were to investigate the prevalence of upper tract involvement in ketamine-associated uropathy, and to determine the predictors of hydronephrosis in patients with a history of ketamine abuse. METHODS: This was a cross-sectional study of a prospective cohort of patients with ketamine-associated uropathy. Data including demographics, pattern of ketamine abuse, pelvic pain and urgency or frequency (PUF) symptom score, uroflowmetry (UFM) parameters, serum renal function, and liver function tests were collected...
June 2017: International Neurourology Journal
https://www.readbyqxmd.com/read/28672811/hypotheses-on-the-potential-of-rice-bran-intake-to-prevent-gastrointestinal-cancer-through-the-modulation-of-oxidative-stress
#15
REVIEW
Bernard M H Law, Mary M Y Waye, Winnie K W So, Sek Ying Chair
Previous studies have suggested the potential involvement of oxidative stress in gastrointestinal cancers. In light of this, research efforts have been focused on the potential of dietary antioxidant intake to prevent gastrointestinal cancer through the modulation of oxidative stress. Rice bran, a by-product of rice milling, has been shown to contain an abundance of phytochemicals, which are dietary antioxidants. To date, a number of studies have shown the antioxidative effect of rice bran intake, and some demonstrated that such an effect may contribute to gastrointestinal cancer prevention, largely through the antioxidative properties of rice bran phytochemicals...
June 24, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28670655/erratum-to-tumour-genesis-syndrome-severe-hypophosphatemia-and-hypokalemia-may-be-ominous-presenting-findings-in-childhood-acute-myeloid-leukaemia
#16
Winnie Ky Chan, Kai On Chang, Wing Hung Lau
No abstract text is available yet for this article.
August 2017: European Journal of Pediatrics
https://www.readbyqxmd.com/read/28662494/gorilloflasca-africana-n-g-n-sp-entodiniomorphida-from-wild-habituated-virunga-mountain-gorillas-gorilla-beringei-beringei-in-rwanda
#17
Akira Ito, Winnie Eckardt, Tara S Stoinski, Thomas R Gillespie, Toshihiro Tokiwa
A new entodiniomorphid ciliate species, Gorilloflasca africana n. g., n. sp. was described from the Virunga mountain gorillas, Gorilla beringei beringei, in Rwanda. It is characterized by a flask-shaped body, a long tubular vestibulum, a round frontal lobe, a large posterior cavity, an ellipsoidal or peanut-shaped macronucleus and a single contractile vacuole. G. africana has the adoral and the vestibular ciliary zones in the buccal area. The adoral ciliary zone is non-retractable, encircling the vestibular opening...
June 13, 2017: European Journal of Protistology
https://www.readbyqxmd.com/read/28659789/a-chinese-chan-based-mind-body-intervention-improves-memory-of-older-adults
#18
Agnes S Chan, Winnie K Cheung, Michael K Yeung, Jean Woo, Timothy Kwok, David H K Shum, Ruby Yu, Mei-Chun Cheung
There is growing interest in the adoption of lifestyle interventions to remediate age-related declines in memory functioning and physical and psychological health among older adults. This study aimed to investigate whether a Chinese Chan-based lifestyle intervention, the Dejian Mind-Body Intervention (DMBI), leads to positive benefits for memory functioning in older adults. Fifty-six adults aged 60 years or older with subjective memory complaints (SMC) were randomly assigned to receive the DMBI or a control intervention (i...
2017: Frontiers in Aging Neuroscience
https://www.readbyqxmd.com/read/28659058/diagnosis-and-treatment-of-developmental-dysplasia-of-the-hip-a-current-practice-of-paediatric-orthopaedic-surgeons
#19
Rakan S Al-Essa, Fares H Aljahdali, Rakan M Alkhilaiwi, Winnie Philip, Ayman H Jawadi, Khalid I Khoshhal
BACKGROUND: Developmental dysplasia of the hip (DDH) is one of the prevalent musculoskeletal conditions in young adults and is a leading cause of hip osteoarthrosis in this age group. The optimum age for surgical intervention when needed is not well established in the literature and the lack of management guidelines and standard practice of DDH leads to different practices worldwide. This study aims to investigate the current practice of paediatric orthopaedic surgeons in diagnosing and treating DDH worldwide and identify points of agreement and disagreement...
May 2017: Journal of Orthopaedic Surgery
https://www.readbyqxmd.com/read/28654915/inhibition-of-fak-kinase-activity-preferentially-targets-cancer-stem-cells
#20
Vihren N Kolev, Winnie F Tam, Quentin G Wright, Sean P McDermott, Christian M Vidal, Irina M Shapiro, Qunli Xu, Max S Wicha, Jonathan A Pachter, David T Weaver
Because cancer stem cells (CSCs) have been implicated in chemo-resistance, metastasis and tumor recurrence, therapeutic targeting of CSCs holds promise to address these clinical challenges to cancer treatment. VS-4718 and VS-6063 are potent inhibitors of focal adhesion kinase (FAK), a non-receptor tyrosine kinase that mediates cell signals transmitted by integrins and growth factor receptors. We report here that inhibition of FAK kinase activity by VS-4718 or VS-6063 preferentially targets CSCs, as demonstrated by a panel of orthogonal CSC assays in cell line models and surgically resected primary breast tumor specimens cultured ex vivo...
June 16, 2017: Oncotarget
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