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https://www.readbyqxmd.com/read/28920002/ep4-antagonism-by-e7046-diminishes-myeloid-immunosuppression-and-synergizes-with-treg-reducing-il-2-diphtheria-toxin-fusion-protein-in-restoring-anti-tumor-immunity
#1
Diana I Albu, Zichun Wang, Kuan-Chun Huang, Jiayi Wu, Natalie Twine, Sarah Leacu, Christy Ingersoll, Lana Parent, Winnie Lee, Diana Liu, Renee Wright-Michaud, Namita Kumar, Galina Kuznetsov, Qian Chen, Wanjun Zheng, Kenichi Nomoto, Mary Woodall-Jappe, Xingfeng Bao
Reprogramming of immunosuppressive tumor microenvironment (TME) by targeting alternatively activated tumor associated macrophages (M2TAM), myeloid-derived suppressor cells (MDSC), and regulatory T cells (Tregs), represents a promising strategy for developing novel cancer immunotherapy. Prostaglandin E2 (PGE2), an arachidonic acid pathway metabolite and mediator of chronic inflammation, has emerged as a powerful immunosuppressor in the TME through engagement with one or more of its 4 receptors (EP1-EP4). We have developed E7046, an orally bioavailable EP4-specific antagonist and show here that E7046 has specific and potent inhibitory activity on PGE2-mediated pro-tumor myeloid cell differentiation and activation...
2017: Oncoimmunology
https://www.readbyqxmd.com/read/28900392/corrigendum-the-impact-of-aerobic-exercise-on-fronto-parietal-network-connectivity-and-its-relation-to-mobility-an-exploratory-analysis-of-a-6-month-randomized-controlled-trial
#2
Chun L Hsu, John R Best, Shirley Wang, Michelle W Voss, Robin G Y Hsiung, Michelle Munkacsy, Winnie Cheung, Todd C Handy, Teresa Liu-Ambrose
[This corrects the article on p. 344 in vol. 11, PMID: 28713255.].
2017: Frontiers in Human Neuroscience
https://www.readbyqxmd.com/read/28895445/strategic-infarct-location-for-post-stroke-cognitive-impairment-a-multivariate-lesion-symptom-mapping-study
#3
Lei Zhao, J Matthijs Biesbroek, Lin Shi, Wenyan Liu, Hugo J Kuijf, Winnie Wc Chu, Jill M Abrigo, Ryan Kl Lee, Thomas Wh Leung, Alexander Yl Lau, Geert J Biessels, Vincent Mok, Adrian Wong
Lesion location is an important determinant for post-stroke cognitive impairment. Although several 'strategic' brain regions have previously been identified, a comprehensive map of strategic brain regions for post-stroke cognitive impairment is lacking due to limitations in sample size and methodology. We aimed to determine strategic brain regions for post-stroke cognitive impairment by applying multivariate lesion-symptom mapping in a large cohort of 410 acute ischemic stroke patients. Montreal Cognitive Assessment at three to six months after stroke was used to assess global cognitive functioning and cognitive domains (memory, language, attention, executive and visuospatial function)...
January 1, 2017: Journal of Cerebral Blood Flow and Metabolism
https://www.readbyqxmd.com/read/28895288/association-between-hiv-and-blood-pressure-in-adults-and-role-of-body-weight-as-a-mediator-cross-sectional-study-in-uganda
#4
Samson Okello, Peter Ueda, Michael Kanyesigye, Emmanuel Byaruhanga, Achilles Kiyimba, Gideon Amanyire, Alex Kintu, Wafaie W Fawzi, Winnie R Muyindike, Goodarz Danaei
The authors sought to describe the association between human immunodeficiency virus (HIV) and blood pressure (BP) levels, and determined the extent to which this relationship is mediated by body weight in a cross-sectional study of HIV-infected and HIV-uninfected controls matched by age, sex, and neighborhood. Mixed-effects models were fit to determine the association between HIV and BP and amount of effect of HIV on BP mediated through body mass index. Data were analyzed from 577 HIV-infected and 538 matched HIV-uninfected participants...
September 12, 2017: Journal of Clinical Hypertension
https://www.readbyqxmd.com/read/28891377/executive-function-measures-for-children-a-scoping-review-of-ecological-validity
#5
Anna Wallisch, Lauren M Little, Evan Dean, Winnie Dunn
Children use executive function (EF) skills within everyday occupations; however, EF poses a difficult and complex construct to measure. Currently, many measures of EF lack applicability to daily life, or ecological validity. The aim of this scoping review was to examine two aspects of ecological validity across measures, assessments, and tasks of EF in children. A scoping review of 355 peer-reviewed articles published between 1996 and 2016 was performed. Searching revealed 43 articles addressing the ecological validity of EF measures for children and 40 measures addressing ecological validity...
September 1, 2017: OTJR: Occupation, Participation and Health
https://www.readbyqxmd.com/read/28889185/statistical-approach-to-quality-assessment-in-liver-transplantation
#6
Harald Schrem, Sophia Volz, Hans-Friedrich Koch, Jill Gwiasda, Priscila Kürsch, Alon Goldis, Daniel Pöhnert, Markus Winny, Jürgen Klempnauer, Alexander Kaltenborn
PURPOSE: This study investigated the utility of retrospective two one-sided cumulative sum (CUSUM) charts combined with multivariable regression analysis in liver transplantation for transplant center benchmarking. METHODS: One thousand seven hundred and forty-nine consecutive adult primary liver transplants (January 1, 1983 to December 31, 2012) were analyzed retrospectively with two one-sided CUSUM chart analysis of 90-day mortality. RESULTS: Three eras and two subseries in latest era 3 were identified due to graphically delineated relevant shifts in mean 90-day mortality...
September 9, 2017: Langenbeck's Archives of Surgery
https://www.readbyqxmd.com/read/28882807/atlantic-salmon-endothelial-cells-from-the-heart-were-more-susceptible-than-fibroblasts-from-the-bulbus-arteriosus-to-four-rna-viruses-but-protected-from-two-viruses-by-dsrna-pretreatment
#7
Phuc H Pham, Winnie W L Tong, Ehab Misk, Ginny Jones, John S Lumsden, Niels C Bols
Heart diseases caused by viruses are major causes of Atlantic salmon aquaculture loss. Two Atlantic salmon cardiovascular cell lines, an endothelial cell line (ASHe) from the heart and a fibroblast cell line (BAASf) from the bulbus arteriosus, were evaluated for their response to four fish viruses, CSV, IPNV, VHSV IVa and VHSV IVb, and the innate immune agonist, double-stranded RNA mimic poly IC. All four viruses caused cytopathic effects in ASHe and BAASf. However, ASHe was more susceptible to all four viruses than BAASf...
September 4, 2017: Fish & Shellfish Immunology
https://www.readbyqxmd.com/read/28881682/inhibition-of-fak-kinase-activity-preferentially-targets-cancer-stem-cells
#8
Vihren N Kolev, Winnie F Tam, Quentin G Wright, Sean P McDermott, Christian M Vidal, Irina M Shapiro, Qunli Xu, Max S Wicha, Jonathan A Pachter, David T Weaver
Because cancer stem cells (CSCs) have been implicated in chemo-resistance, metastasis and tumor recurrence, therapeutic targeting of CSCs holds promise to address these clinical challenges to cancer treatment. VS-4718 and VS-6063 are potent inhibitors of focal adhesion kinase (FAK), a non-receptor tyrosine kinase that mediates cell signals transmitted by integrins and growth factor receptors. We report here that inhibition of FAK kinase activity by VS-4718 or VS-6063 preferentially targets CSCs, as demonstrated by a panel of orthogonal CSC assays in cell line models and surgically resected primary breast tumor specimens cultured ex vivo...
August 1, 2017: Oncotarget
https://www.readbyqxmd.com/read/28878390/impact-of-nutritional-supplements-on-cognitive-development-of-children-in-developing-countries-a-meta-analysis
#9
Patrick Ip, Frederick Ka Wing Ho, Nirmala Rao, Jin Sun, Mary Eming Young, Chun Bong Chow, Winnie Tso, Kam Lun Hon
Nutritional supplements may be important on cognition but the evidence is heterogeneous. This meta-analysis aimed (1) to determine whether nutritional supplements provided to pregnant women or young children could improve cognitive development of children in developing countries, and (2) to explore how supplementation characteristics could improve children's cognitive outcomes. This meta-analysis examined nutritional supplementation studies in 9 electronic databases and 13 specialist websites. Experimental studies were included if they were published from 1992 to 2016, were conducted in developing countries, had nutritional supplementation for pregnant women or children aged ≤8, and reported effect sizes on cognitive outcomes...
September 6, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28872536/improved-safety-and-cost-savings-from-reductions-in-cast-saw-burns-after-simulation-based-education-for-orthopaedic-surgery-residents
#10
Donald S Bae, Hayley Lynch, Katherine Jamieson, C Winnie Yu-Moe, Christopher Roussin
BACKGROUND: The purpose of this investigation was to characterize the clinical efficacy and cost-effectiveness of simulation training aimed at reducing cast-saw injuries. METHODS: Third-year orthopaedic residents underwent simulation-based instruction on distal radial fracture reduction, casting, and cast removal using an oscillating saw. The analysis compared incidences of cast-saw injuries and associated costs before and after the implementation of the simulation curriculum...
September 6, 2017: Journal of Bone and Joint Surgery. American Volume
https://www.readbyqxmd.com/read/28860982/using-large-scale-statistical-chinese-brain-template-chinese2020-in-popular-neuroimage-analysis-toolkits
#11
Lin Shi, Peipeng Liang, Yishan Luo, Kai Liu, Vincent C T Mok, Winnie C W Chu, Defeng Wang, Kuncheng Li
Given that the morphology of Chinese brains statistically differs from that of Caucasian, there is an urgent need to develop a Chinese brain template for neuroimaging studies in Chinese populations. Based on a multi-center dataset, we developed a statistical Chinese brain template, named as Chinese2020 (Liang et al., 2015). This new Chinese brain atlas has been validated in brain normalization and segmentation for anatomical Magnetic Resonance Imaging (MRI) studies, and is publicly available at http://www.chinese-brain-atlases...
2017: Frontiers in Human Neuroscience
https://www.readbyqxmd.com/read/28857384/translation-and-validation-of-translation-in-cross-cultural-research-strategies-used-in-a-study-of-cervical-cancer-screening-among-ethnic-minorities
#12
Dorothy N S Chan, Winnie K W So
AIMS: A discussion of the challenges encountered during instrument translation and validation while researching cervical cancer screening among ethnic minorities and the strategies used to overcome them. BACKGROUND: Given the increasing ethnic and cultural diversity of populations in different countries, culturally sensitive instruments are needed to evaluate people's attitudes, perceptions, and health practices. Often, such instruments are lacking in the study population's language...
August 31, 2017: International Journal of Nursing Practice
https://www.readbyqxmd.com/read/28856539/alcohol-types-and-hiv-disease-progression-among-hiv-infected-drinkers-not-yet-on-antiretroviral-therapy-in-russia-and-uganda
#13
Stephen B Asiimwe, Robin Fatch, Gregory Patts, Michael Winter, Christine Lloyd-Travaglini, Nneka Emenyonu, Winnie Muyindike, Allen Kekibiina, Elena Blokhina, Natalia Gnatienko, Evgeny Kruptisky, Debbie M Cheng, Jeffrey H Samet, Judith A Hahn
In HIV-infected drinkers, alcohol types more likely to cause inflammation could plausibly increase the risk of HIV disease progression. We therefore assessed the association between alcohol type and plasma HIV RNA level (HIV viral load) among HIV-infected drinkers not on antiretroviral therapy (ART) in Russia and Uganda. We analyzed the data of participants from cohorts in Russia and Uganda and assessed their HIV viral load at enrollment by the alcohol type predominantly consumed. We defined predominant alcohol type as the alcohol type contributing >50% of total alcohol consumption in the 1 month (Russia) or 3 months (Uganda) prior to enrollment...
August 30, 2017: AIDS and Behavior
https://www.readbyqxmd.com/read/28851781/protocol-for-a-nationwide-survey-of-primary-health-care-in-china-the-china-peace-patient-centered-evaluative-assessment-of-cardiac-events-mpp-million-persons-project-primary-health-care-survey
#14
Meng Su, Qiuli Zhang, Jiapeng Lu, Xi Li, Na Tian, Yun Wang, Winnie Yip, Kar Keung Cheng, George A Mensah, Ralph I Horwitz, Elias Mossialos, Harlan M Krumholz, Lixin Jiang
INTRODUCTION: China has pioneered advances in primary health care (PHC) and public health for a large and diverse population. To date, the current state of PHC in China has not been subjected to systematic assessments. Understanding variations in primary care services could generate opportunities for improving the structure and function of PHC. METHODS AND ANALYSIS: This paper describes a nationwide PHC study (PEACE MPP Primary Health Care Survey) conducted across 31 provinces in China...
August 28, 2017: BMJ Open
https://www.readbyqxmd.com/read/28845202/reflection-as-a-deliberative-and-distributed-practice-assessing-neuro-enhancement-technologies-via-mutual-learning-exercises-mles
#15
Hub Zwart, Jonna Brenninkmeijer, Peter Eduard, Lotte Krabbenborg, Sheena Laursen, Gema Revuelta, Winnie Toonders
In 1968, Jürgen Habermas claimed that, in an advanced technological society, the emancipatory force of knowledge can only be regained by actively recovering the 'forgotten experience of reflection'. In this article, we argue that, in the contemporary situation, critical reflection requires a deliberative ambiance, a process of mutual learning, a consciously organised process of deliberative and distributed reflection. And this especially applies, we argue, to critical reflection concerning a specific subset of technologies which are actually oriented towards optimising human cognition (neuro-enhancement)...
2017: Nanoethics
https://www.readbyqxmd.com/read/28844844/promoting-collaborations-between-radiologists-and-scientists
#16
REVIEW
John-Paul J Yu, Bradley M Spieler, Tiffany L Chan, Elizabeth M Johnson, Vikas Gulani, Kim L Sandler, Ponnada A Narayana, Winnie A Mar, James M Brian, Chin K Ng
Radiology as a discipline thrives on the dynamic interplay between technological and clinical advances. Progress in almost all facets of the imaging sciences is highly dependent on complex tools sourced from physics, engineering, biology, and the clinical sciences to obtain, process, and view imaging studies. The application of these tools, however, requires broad and deep medical knowledge about disease pathophysiology and its relationship with medical imaging. This relationship between clinical medicine and imaging technology, nurtured and fostered over the past 75 years, has cultivated extraordinarily rich collaborative opportunities between basic scientists, engineers, and physicians...
August 24, 2017: Academic Radiology
https://www.readbyqxmd.com/read/28839971/life-style-modification-at-the-edge
#17
EDITORIAL
Winnie Chan, Adrian Baranchuk
No abstract text is available yet for this article.
July 2017: Journal of Thoracic Disease
https://www.readbyqxmd.com/read/28838767/c4-nephritic-factors-in-c3-glomerulopathy-a-case-series
#18
Yuzhou Zhang, Nicole C Meyer, Fernando C Fervenza, Winnie Lau, Adam Keenan, Gabriel Cara-Fuentes, Dingwu Shao, Aalia Akber, Veronique Fremeaux-Bacchi, Sanjeev Sethi, Carla M Nester, Richard J H Smith
BACKGROUND: C3 glomerulopathy (C3G) defines a group of rare complement-mediated kidney diseases with a shared underlying pathophysiology: dysregulation of complement in the fluid phase and glomerular microenvironment. Dysregulation can be driven by autoantibodies to C3 and C5 convertases. STUDY DESIGN: Case series. SETTING & PARTICIPANTS: 168 patients with C3G (dense deposit disease, 68; C3 glumerulonephritis, 100) selected from our C3G biobank...
August 22, 2017: American Journal of Kidney Diseases: the Official Journal of the National Kidney Foundation
https://www.readbyqxmd.com/read/28838631/true-communication-skills-assessment-in-interdepartmental-osce-stations-standard-setting-using-the-maas-global-and-edug
#19
Winny Setyonugroho, Thomas Kropmans, Ruth Murphy, Peter Hayes, Jan van Dalen, Kieran M Kennedy
BACKGROUND: Comparing outcome of clinical skills assessment is challenging. This study proposes reliable and valid comparison of communication skills (1) assessment as practiced in Objective Structured Clinical Examinations (2). The aim of the present study is to compare CS assessment, as standardized according to the MAAS Global, between stations in a single undergraduate medical year. METHODS: An OSCE delivered in an Irish undergraduate curriculum was studied...
July 11, 2017: Patient Education and Counseling
https://www.readbyqxmd.com/read/28838234/structural-characterization-of-intact-glycoconjugates-by-tandem-mass-spectrometry-using-electron-induced-dissociation
#20
Y L Elaine Wong, Xiangfeng Chen, Ri Wu, Y L Winnie Hung, T-W Dominic Chan
Characterizing the structures of glycoconjungates is important because of glycan heterogeneity and structural complexity of aglycon. The presence of relatively weak glycosidic linkages leads to preferential cleavages that limit the acquisition of structural information under typical mass spectrometry dissociation conditions, such as collision-induced dissociation (CID) and infrared multiphoton dissociation. In this paper, we explored the dissociation behaviors of different members of glycoconjugates, including glycopeptides, glycoalkaloids, and glycolipids, under electron-induced dissociation (EID) conditions...
September 7, 2017: Analytical Chemistry
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