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https://www.readbyqxmd.com/read/29327090/alcohol-use-and-unprotected-sex-among-hiv-infected-ugandan-adults-findings-from-an-event-level-study
#1
Sarah E Woolf-King, Robin Fatch, Debbie M Cheng, Winnie Muyindike, Christine Ngabirano, Allen Kekibiina, Nneka Emenyonu, Judith A Hahn
While alcohol is a known risk factor for HIV infection in sub-Saharan Africa (SSA), studies designed to investigate the temporal relationship between alcohol use and unprotected sex are lacking. The purpose of this study was to determine whether alcohol used at the time of a sexual event is associated with unprotected sex at that same event. Data for this study were collected as part of two longitudinal studies of HIV-infected Ugandan adults. A structured questionnaire was administered at regularly scheduled cohort study visits in order to assess the circumstances (e...
January 11, 2018: Archives of Sexual Behavior
https://www.readbyqxmd.com/read/29324907/correction-ank1-is-up-regulated-in-laser-captured-microglia-in-alzheimer-s-brain-the-importance-of-addressing-cellular-heterogeneity
#2
Diego Mastroeni, Shobana Sekar, Jennifer Nolz, Elaine Delvaux, Katie Lunnon, Jonathan Mill, Winnie S Liang, Paul D Coleman
[This corrects the article DOI: 10.1371/journal.pone.0177814.].
2018: PloS One
https://www.readbyqxmd.com/read/29316889/a-systematic-review-of-chronic-disease-management-interventions-in-primary-care
#3
Rebecca Reynolds, Sarah Dennis, Iqbal Hasan, Jan Slewa, Winnie Chen, David Tian, Sangeetha Bobba, Nicholas Zwar
BACKGROUND: Primary and community care are key settings for the effective management of long term conditions. We aimed to evaluate the pattern of health outcomes in chronic disease management interventions for adults with physical health problems implemented in primary or community care settings. METHODS: The methods were based on our previous review published in 2006. We performed database searches for articles published from 2006 to 2014 and conducted a systematic review with narrative synthesis using the Cochrane Effective Practice and Organisation of Care taxonomy to classify interventions and outcomes...
January 9, 2018: BMC Family Practice
https://www.readbyqxmd.com/read/29314147/cfdna-screening-and-diagnosis-of-monogenic-disorders-where-are-we-heading
#4
Eunice Ka Long Chiu, Winnie Wai In Hui, Rossa Wai Kwun Chiu
Cell-free fetal DNA analysis for non-invasive prenatal screening of fetal chromosomal aneuploidy has been widely adopted for clinical use. Fetal monogenic diseases have also been shown to be amenable to non-invasive detection by maternal plasma DNA analysis. A number of recent technological developments in this area has increased the level of clinical interest, particularly as one approach does not require customized reagents per mutation. The mutational status of the fetus can be assessed by determining which parental haplotype that fetus has inherited based on the detection of haplotype-associated SNP alleles in maternal plasma...
January 5, 2018: Prenatal Diagnosis
https://www.readbyqxmd.com/read/29304290/effects-of-metformin-on-insulin-resistance-and-metabolic-disorders-in-tumor-bearing-rats-with-advanced-cachexia
#5
Flaviane de Fatima Silva, Milene Ortiz-Silva, Winny Beatriz de Souza Galia, Priscila Cassolla, Francemilson Goulart da Silva, Maria Fernanda Rodrigues Graciano, Angelo Carpinelli, Helenir Medri de Souza
Metformin (MET) is widely used in the correction of insulin (INS) resistance and metabolic abnormalities in type 2 diabetes. However, its effect on INS resistance and metabolic disorders associated with cancer cachexia is not established. We investigated the MET effects, isolated or associated with INS, on INS resistance and metabolic changes induced by Walker-256 tumor in rats with advanced cachexia. MET (500 mg.kg-1, oral) and MET + INS (NPH, 1.0 IU.kg-1, sc) were administered during 12 days, starting on the day of tumor cell inoculation...
January 5, 2018: Canadian Journal of Physiology and Pharmacology
https://www.readbyqxmd.com/read/29303844/alcohol-use-and-hiv-disease-progression-in-an-antiretroviral-na%C3%A3-ve-cohort
#6
Judith A Hahn, Debbie M Cheng, Nneka I Emenyonu, Christine Lloyd-Travaglini, Robin Fatch, Starley B Shade, Christine Ngabirano, Julian Adong, Kendall Bryant, Winnie R Muyindike, Jeffrey H Samet
BACKGROUND: Alcohol use has been shown to accelerate disease progression in experimental studies of simian immunodeficiency virus in macaques, but the results in observational studies of HIV have been conflicting. METHODS: We conducted a prospective cohort study of the impact of unhealthy alcohol use on CD4 cell count among HIV-infected persons in southwestern Uganda not yet eligible for antiretroviral treatment (ART). Unhealthy alcohol consumption was 3-month Alcohol Use Disorders Identification Test - Consumption (AUDIT-C) positive (≥3 for women, ≥4 for men) and/or phosphatidylethanol (PEth - an alcohol biomarker) ≥50 ng/ml, modeled as a time-dependent variable in a linear mixed effects model of CD4 count...
January 4, 2018: Journal of Acquired Immune Deficiency Syndromes: JAIDS
https://www.readbyqxmd.com/read/29300976/integrating-new-approaches-to-atrial-fibrillation-management-the-6th-afnet-ehra-consensus-conference
#7
Dipak Kotecha, Günter Breithardt, A John Camm, Gregory Y H Lip, Ulrich Schotten, Anders Ahlsson, David Arnar, Dan Atar, Angelo Auricchio, Jeroen Bax, Stefano Benussi, Carina Blomstrom-Lundqvist, Martin Borggrefe, Giuseppe Boriani, Axel Brandes, Hugh Calkins, Barbara Casadei, Manuel Castellá, Winnie Chua, Harry Crijns, Dobromir Dobrev, Larissa Fabritz, Martin Feuring, Ben Freedman, Andrea Gerth, Andreas Goette, Eduard Guasch, Doreen Haase, Stephane Hatem, Karl Georg Haeusler, Hein Heidbuchel, Jeroen Hendriks, Craig Hunter, Stefan Kääb, Stefanie Kespohl, Ulf Landmesser, Deirdre A Lane, Thorsten Lewalter, Lluís Mont, Michael Nabauer, Jens C Nielsen, Michael Oeff, Jonas Oldgren, Ali Oto, Laurent Pison, Tatjana Potpara, Ursula Ravens, Isabelle Richard-Lordereau, Michiel Rienstra, Irina Savelieva, Renate Schnabel, Moritz F Sinner, Philipp Sommer, Sakis Themistoclakis, Isabelle C Van Gelder, Panagiotis E Vardas, Atul Verma, Reza Wakili, Evelyn Weber, David Werring, Stephan Willems, André Ziegler, Gerhard Hindricks, Paulus Kirchhof
There are major challenges ahead for clinicians treating patients with atrial fibrillation (AF). The population with AF is expected to expand considerably and yet, apart from anticoagulation, therapies used in AF have not been shown to consistently impact on mortality or reduce adverse cardiovascular events. New approaches to AF management, including the use of novel technologies and structured, integrated care, have the potential to enhance clinical phenotyping or result in better treatment selection and stratified therapy...
January 2, 2018: Europace: European Pacing, Arrhythmias, and Cardiac Electrophysiology
https://www.readbyqxmd.com/read/29298939/environmental-conditions-shape-the-temporal-pattern-of-investment-in-reproduction-and-survival
#8
Valeria Marasco, Winnie Boner, Kate Griffiths, Britt Heidinger, Pat Monaghan
The relationship between environmental stress exposure and ageing is likely to vary with stressor severity, life-history stage and the time scale over which effects are measured. Such factors could influence whether stress exposure accelerates or slows the ageing process, but their interactions have not previously been experimentally investigated. We found that experimental exposure of zebra finches to mildly challenging environmental circumstances from young to old adulthood, which increased exposure to stress hormones, reduced breeding performance during early adulthood, but had positive effects when individuals were bred in old adulthood...
January 10, 2018: Proceedings. Biological Sciences
https://www.readbyqxmd.com/read/29290753/tantalum-sulfide-nanosheets-as-a-theranostic-nanoplatform-for-computed-tomography-imaging-guided-combinatorial-chemo-photothermal-therapy
#9
Yanlan Liu, Xiaoyuan Ji, Jianhua Liu, Winnie W L Tong, Diana Askhatova, Jinjun Shi
Near-infrared (NIR)-absorbing metal-based nanomaterials have shown tremendous potential for cancer therapy, given their facile and controllable synthesis, efficient photothermal conversion, capability of spatiotemporal-controlled drug delivery, and intrinsic imaging function. Tantalum (Ta) is among the most biocompatible metals and arouses negligible adverse biological responses in either oxidized or reduced forms, and thus Ta-derived nanomaterials represent promising candidates for biomedical applications...
October 19, 2017: Advanced Functional Materials
https://www.readbyqxmd.com/read/29290746/prolonged-dexmedetomidine-infusion-and-drug-withdrawal-in-critically-ill-children
#10
Astrid S Haenecour, Winnie Seto, Charline M Urbain, Derek Stephens, Peter C Laussen, Corrine R Balit
OBJECTIVE: To characterise the incidence, symptoms and risk factors for withdrawal associated with prolonged dexmedetomidine infusion in paediatric critically ill patients. METHODS: Retrospective chart review in the paediatric intensive care unit and the cardiac critical care unit of a single tertiary children's hospital. Patients up to 18 years old, who received dexmedetomidine for longer than 48 hours were included. RESULTS: A total of 52 patients accounted for 68 unique dexmedetomidine treatment courses of more than 48 hours...
November 2017: Journal of Pediatric Pharmacology and Therapeutics: JPPT: the Official Journal of PPAG
https://www.readbyqxmd.com/read/29289391/acute-diverticulitis-in-renal-transplant-patients-should-we-treat-them-differently
#11
Jeremy Sugrue, Joanna Lee, Christina Warner, Sany Thomas, Ivo Tzvetanov, Winnie Mar, Anders Mellgren, Johan Nordenstam
BACKGROUND: Current guidelines suggest that transplant patients with acute diverticulitis should be managed aggressively with early operative intervention to reduce morbidity and mortality. This study compared the treatment choices and clinical outcomes between renal transplant patients and immunocompetent patients with acute diverticulitis. METHODS: A retrospective review was performed of all patients who were admitted with acute diverticulitis between 2002 and 2015 at a single academic institution...
December 27, 2017: Surgery
https://www.readbyqxmd.com/read/29285557/transfusion-practices-at-end-of-life-for-hematopoietic-stem-cell-transplant-patients
#12
Winnie S Wang, Joseph D Ma, Sandahl H Nelson, Carolyn Revta, Gary T Buckholz, Carolyn Mulroney, Eric J Roeland
PURPOSE: Limited data exist regarding transfusion practices at end of life (EOL) for hematopoietic stem cell transplant (HSCT) patients. The purpose of this study was to examine red blood cell (RBC) and platelet transfusion practices in HSCT patients who enrolled or did not enroll in hospice. METHODS: This was a single-center, retrospective chart review in deceased HSCT patients. The primary objective was to determine the mean difference between the last transfusion and death in HSCT patients (n = 116) who enrolled or did not enroll in hospice...
December 28, 2017: Supportive Care in Cancer: Official Journal of the Multinational Association of Supportive Care in Cancer
https://www.readbyqxmd.com/read/29283448/pharmacokinetics-and-safety-of-momelotinib-in-subjects-with-hepatic-or-renal-impairment
#13
Yan Xin, Jun Kawashima, Winnie Weng, Ellen Kwan, Thomas Tarnowski, Jeffrey A Silverman
Momelotinib is a Janus kinase 1/2 inhibitor in clinical development for the treatment of myelofibrosis. Two phase 1 open-label, parallel-group, adaptive studies were conducted to evaluate the pharmacokinetics of a single 200-mg oral dose of momelotinib in subjects with hepatic or renal impairment compared with healthy matched control subjects with normal hepatic or renal function. Plasma pharmacokinetics of momelotinib and its major active metabolite, M21, were evaluated, and geometric least-squares mean ratios (GMRs) and associated 90% confidence intervals (CIs) for impaired versus each control group were calculated for plasma exposures (area under concentration-time curve from time 0 to ∞ [AUC∞ ] and maximum concentration) of momelotinib and M21...
December 28, 2017: Journal of Clinical Pharmacology
https://www.readbyqxmd.com/read/29280720/sensory-processing-in-the-general-population-adaptability-resiliency-and-challenging-behavior
#14
Evan E Dean, Lauren Little, Scott Tomchek, Winnie Dunn
Sensory processing is a personal trait that can contribute to challenging behavior. Protective factors, such as resiliency, can support children in managing their behavior, yet little research has addressed the contribution of sensory processing to protective factors. Therefore, in this cross-sectional study we aimed to determine the contribution of sensory processing (using the Sensory Profile-2) to challenging behavior and protective factors (using the Behavior Assessment System for Children, 2nd ed., Parent Rating Scales) in a sample of 51 children ages 6-11 yr from the general U...
January 2018: American Journal of Occupational Therapy: Official Publication of the American Occupational Therapy Association
https://www.readbyqxmd.com/read/29276823/engineering-multifunctional-rnai-nanomedicine-to-concurrently-target-cancer-hallmarks-for-combinatorial-therapy
#15
Yanlan Liu, Xiaoyuan Ji, Winnie Tong, Diana Askhatova, Tingyuan Yang, Hongwei Cheng, Yuzhuo Wang, Jinjun Shi
Cancer hallmarks have been providing a logical framework for understanding the complexity and heterogeneity of tumor biology, leading to the discovery of various promising targets for cancer therapy. Herein, we report a novel amorphous iron oxide nanoparticle (NP)-based RNAi strategy to co-target two cancer hallmarks. The NP technology can modulate the glycolysis pathway by silencing MCT4 to induce tumor cell acidosis, and concurrently exacerbate oxidative stress in tumor cells via the Fenton-like reaction...
December 24, 2017: Angewandte Chemie
https://www.readbyqxmd.com/read/29276070/a-piecewise-mass-spring-damper-model-of-the-human-breast
#16
Yiqing Cai, Lihua Chen, Winnie Yu, Jie Zhou, Frances Wan, Minyoung Suh, Daniel Hung-Kay Chow
Previous models to predict breast movement whilst performing physical activities have, erroneously, assumed uniform elasticity within the breast. Consequently, the predicted displacements have not yet been satisfactorily validated. In this study, real time motion capture of the natural vibrations of a breast that followed, after raising and allowing it to fall freely, revealed an obvious difference in the vibration characteristics above and below the static equilibrium position. This implied that the elastic and viscous damping properties of a breast could vary under extension or compression...
December 14, 2017: Journal of Biomechanics
https://www.readbyqxmd.com/read/29262375/physical-mechanisms-driving-cell-sorting-in-hydra
#17
Olivier Cochet-Escartin, Tiffany T Locke, Winnie H Shi, Robert E Steele, Eva-Maria S Collins
Cell sorting, whereby a heterogeneous cell mixture organizes into distinct tissues, is a fundamental patterning process in development. Hydra is a powerful model system for carrying out studies of cell sorting in three dimensions, because of its unique ability to regenerate after complete dissociation into individual cells. The physicists Alfred Gierer and Hans Meinhardt recognized Hydra's self-organizing properties more than 40 years ago. However, what drives cell sorting during regeneration of Hydra from cell aggregates is still debated...
December 19, 2017: Biophysical Journal
https://www.readbyqxmd.com/read/29245897/comparative-analysis-of-primary-versus-relapse-refractory-dlbcl-identifies-shifts-in-mutation-spectrum
#18
Danielle M Greenawalt, Winnie S Liang, Sakina Saif, Justin Johnson, Petar Todorov, Austin Dulak, Daniel Enriquez, Rebecca Halperin, Ambar Ahmed, Vladislav Saveliev, John Carpten, David Craig, J Carl Barrett, Brian Dougherty, Michael Zinda, Stephen Fawell, Jonathan R Dry, Kate Byth
Current understanding of the mutation spectrum of relapsed/refractory (RR) tumors is limited. We performed whole exome sequencing (WES) on 47 diffuse large B cell lymphoma (DLBCL) tumors that persisted after R-CHOP treatment, 8 matched to primary biopsies. We compared genomic alterations from the RR cohort against two treatment-naïve DLBCL cohorts (n=112). While the overall number and types of mutations did not differ significantly, we identified frequency changes in DLBCL driver genes. The overall frequency of MYD88 mutant samples increased (12% to 19%), but we noted a decrease in p...
November 21, 2017: Oncotarget
https://www.readbyqxmd.com/read/29244037/a-psychometric-evaluation-of-the-chinese-version-of-the-m-d-anderson-symptom-inventory-heart-failure-in-chinese-cancer-patients-with-concurrent-heart-failure
#19
Sek Ying Chair, Qun Wang, Mingming Yu, Winnie Kwok Wei So, Chang Tian, Janet Wing Hung Sit, Eliza Mi Ling Wong, Carmen Wing Han Chan, Anecita Fadol
PURPOSE: The purpose of the study was to translate the M.D. Anderson Symptom Inventory-Heart Failure (MDASI-HF), a specific instrument to assess symptoms in cancer patients with concurrent heart failure (HF), into Mandarin Chinese and to examine its psychometric properties in Chinese cancer patients. DESIGN: A translation and psychometric evaluation design was used. METHODS: The translation of the MDASI-HF into Mandarin Chinese followed Brislin's model with the four steps: translation, monolingual assessment, backward translation, and comparison...
November 2017: Rehabilitation Nursing: the Official Journal of the Association of Rehabilitation Nurses
https://www.readbyqxmd.com/read/29240517/sensory-processing-patterns-in-autism-attention-deficit-hyperactivity-disorder-and-typical-development
#20
Lauren M Little, Evan Dean, Scott Tomchek, Winnie Dunn
AIMS: The purpose of this study was to examine sensory processing in children ages 3-14 years with autism spectrum disorder (ASD), attention deficit hyperactivity disorder (ADHD), and typical development (TD) using the Sensory Profile 2nd Edition (Dunn, 2014). METHODS: Participants included 239 children (ASD = 77; ADHD = 78; TD = 84) matched on age and gender. Multivariate analysis of covariance was used to compare the extent to which the three grsoups differed on sensory processing patterns (i...
December 14, 2017: Physical & Occupational Therapy in Pediatrics
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