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https://www.readbyqxmd.com/read/27909261/measuring-nutrition-governance-an-analysis-of-commitment-capability-and-collaboration-in-nepal
#1
Patrick Webb, Shibani Ghosh, Robin Shrestha, Grace Namirembe, Sabi Gurung, Diplav Sapkota, Winnie Fay Bell, Dale Davis, Eileen Kennedy, Shailes Neupane, Swetha Manohar, Kedar Baral
BACKGROUND: Global commitments to nutrition have supported calls for better evidence to support effective investments at national level. However, too little attention has so far been paid to the role of governance in achieving impacts. OBJECTIVE: This article explores the ways by which the commitment and capabilities of policy implementers affect collaborative efforts for achieving nutrition goals. METHODS: Over 1370 structured interviews were held with government and nongovernment officials over 3 years in 21 districts...
December 2016: Food and Nutrition Bulletin
https://www.readbyqxmd.com/read/27907241/cheiloscopy-lip-print-inter-rater-reliability
#2
Winnie Furnari, Malvin N Janal
Lip print analysis, or cheiloscopy, has the potential to join fingerprints and retinal scans as an additional method to determine human identification. This preliminary study sought to determine agreement among 20 raters, forensic odontologists, using an often referenced system that categorizes lip prints into six classes related to the dominant pattern of vertical, horizontal, and intersecting lines. Lip prints were taken from 13 individuals, and raters categorized eight distinct regions of each print. In addition to ratings made while viewing the actual prints, the raters repeated the exercise using photographs of the lip prints...
December 1, 2016: Journal of Forensic Sciences
https://www.readbyqxmd.com/read/27902926/dental-bleaching-with-the-use-of-violet-light-only-reality-or-future
#3
Andréa Dias Neves Lago, Winnie Dandara Rocha Ferreira, Guilherme Silva Furtado
No abstract text is available yet for this article.
November 27, 2016: Photodiagnosis and Photodynamic Therapy
https://www.readbyqxmd.com/read/27900151/can-the-otago-falls-prevention-program-be-delivered-by-video-a-feasibility-study
#4
Jennifer C Davis, Chun Liang Hsu, Winnie Cheung, Penny M A Brasher, Linda C Li, Karim M Khan, Jonathan Sykes, Dawn A Skelton, Teresa Liu-Ambrose
OBJECTIVES: We assessed the feasibility of delivering the Otago Exercise Programme (OEP) via an interactive DVD (ie, OEP-DVD) in combination with monthly physical therapist phone calls to older adults. DESIGN: This pre-post (baseline and 6-month follow-up) study included an intervention group (n=61) based in a rural location and a control group (n=21) based in a city. SETTING: Sechelt and Vancouver, British Columbia. PARTICIPANTS: 82 community-dwelling adults ≥75 years...
2016: BMJ Open Sport & Exercise Medicine
https://www.readbyqxmd.com/read/27896836/radiosynthesis-and-biological-evaluation-of-the-new-pde10a-radioligand-18-f-aq28a
#5
Sally Wagner, Rodrigo Teodoro, Winnie Deuther-Conrad, Mathias Kranz, Matthias Scheunemann, Steffen Fischer, Barbara Wenzel, Ute Egerland, Norbert Hoefgen, Jörg Steinbach, Peter Brust
Cyclic nucleotide phosphodiesterase 10A (PDE10A) regulates the level of the second messengers cAMP and cGMP in particular in brain regions assumed to be associated with neurodegenerative and psychiatric diseases. A better understanding of the pathophysiological role of the expression of PDE10A could be obtained by quantitative imaging of the enzyme by positron emission tomography (PET). Thus, in this study we developed, radiolabeled, and evaluated a new PDE10A radioligand, 8-bromo-1-(6-[(18) F]fluoropyridin-3-yl)-3,4-dimethylimidazo[1,5-a]quinoxaline ([(18) F]AQ28A)...
November 29, 2016: Journal of Labelled Compounds & Radiopharmaceuticals
https://www.readbyqxmd.com/read/27881401/alterations-of-colonic-function-in-the-winnie-mouse-model-of-spontaneous-chronic-colitis
#6
Ainsley M Robinson, Ahmed A Rahman, Simona Elisa Carbone, Sarron Randall-Demllo, Rhiannon Filippone, Joel Charles Bornstein, Rajaraman Eri, Kulmira Nurgali
The Winnie mouse, carrying a missense mutation in Muc2, is a model for chronic intestinal inflammation demonstrating symptoms closely resembling inflammatory bowel disease (IBD). Alterations to the immune environment, morphological structure and innervation of Winnie mouse colon have been identified; however analyses of intestinal transit and colonic functions have not been conducted. In this study, we investigated in vivo intestinal transit in radiographic studies and in vitro motility of the isolated colon in organ bath experiments...
November 23, 2016: American Journal of Physiology. Gastrointestinal and Liver Physiology
https://www.readbyqxmd.com/read/27861759/metabolic-syndrome-and-risk-of-esophageal-adenocarcinoma-in-elderly-patients-in-the-united-states-an-analysis-of-seer-medicare-data
#7
Jennifer Drahos, Winnie Ricker, Ruth M Pfeiffer, Michael B Cook
BACKGROUND: Metabolic syndrome (MetS) is associated with cancer risk and increases the risk of Barrett esophagus, which is the precursor lesion of esophageal adenocarcinoma (EA), primarily in the absence of gastroesophageal reflux disease (GERD). However, to the authors' knowledge, little is known regarding whether MetS is associated with the risk of EA. METHODS: Using the Surveillance, Epidemiology, and End Results (SEER)-Medicare-linked database, the authors evaluated whether MetS was associated with EA...
November 8, 2016: Cancer
https://www.readbyqxmd.com/read/27856301/sulfur-fumigation-reducing-systemic-exposure-of-ginsenosides-and-weakening-immunomodulatory-activity-of-ginseng
#8
Bin Ma, Winnie Lai Ting Kan, He Zhu, Song-Lin Li, Ge Lin
ETHNOPHARMACOLOGICAL RELEVANCE: Ginseng (Ginseng Radix et Rhizoma) is used worldwide for its miracle tonic effects, especially for its immunomodulatory activities. Sulfur fumigation, a fast and convenient method to prevent pesticidal and bacterial contamination in the food industry, has been recently employed during post-harvest processing of ginseng. Our previous studies demonstrated that sulfur fumigation significantly altered the chemical profile of the bioactive ingredients in ginseng...
November 15, 2016: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/27842474/a-cross-diagnostic-investigation-of-the-differential-impact-of-discrimination-on-clinical-and-personal-recovery
#9
Winnie W S Mak, Randolph C H Chan, Samuel Y S Wong, Joseph T F Lau, Wai Kwong Tang, Alan K L Tang, Tin Po Chiang, Sammy K W Cheng, Fu Chan, Fanny M Cheung, Jean Woo, Diana T F Lee
OBJECTIVE: Although the negative association between discrimination and recovery has been established, only a few studies have attempted to investigate the underlying mechanism of how perceived discrimination dampens both clinical and personal recovery among people with psychiatric disorders. This study aimed to examine the mediating roles of self-stigma and mental health service engagement in the relationship between perceived discrimination and recovery. METHODS: A total of 374 people (half men and half women; mean±SD age=43...
November 15, 2016: Psychiatric Services: a Journal of the American Psychiatric Association
https://www.readbyqxmd.com/read/27836587/hiv-aids-and-contraceptive-use-factors-associated-with-contraceptive-use-among-sexually-active-hiv-positive-women-in-kenya
#10
Monica A Magadi, Winnie A Magadi
OBJECTIVES: With increased availability of anti-retroviral therapy and improved survival for people living with HIV, more HIV-positive women are leading full reproductive lives. However, HIV-positive women have special contraceptive needs/concerns. This paper examines the individual and community-level HIV/AIDS factors associated with contraceptive use and compares predictors of contraceptive uptake between HIV-positive and HIV-negative women in Kenya. STUDY DESIGN: The study is based on secondary analysis of cross-sectional data of a sample of 9132 sexually-active women of reproductive age from the Kenya Demographic and Health Surveys collected in 2003 and 2008...
November 8, 2016: Contraception
https://www.readbyqxmd.com/read/27824648/fecal-microbiota-and-metabolome-in-a-mouse-model-of-spontaneous-chronic-colitis-relevance-to-human-inflammatory-bowel-disease
#11
Ainsley M Robinson, Shakuntla V Gondalia, Avinash V Karpe, Rajaraman Eri, David J Beale, Paul D Morrison, Enzo A Palombo, Kulmira Nurgali
BACKGROUND: Dysbiosis of the gut microbiota may be involved in the pathogenesis of inflammatory bowel disease (IBD). However, the mechanisms underlying the role of the intestinal microbiome and metabolome in IBD onset and its alteration during active treatment and recovery remain unknown. Animal models of chronic intestinal inflammation with similar microbial and metabolomic profiles would enable investigation of these mechanisms and development of more effective treatments. Recently, the Winnie mouse model of colitis closely representing the clinical symptoms and characteristics of human IBD has been developed...
November 7, 2016: Inflammatory Bowel Diseases
https://www.readbyqxmd.com/read/27818101/defining-nadh-driven-allostery-regulating-apoptosis-inducing-factor
#12
Chris A Brosey, Chris Ho, Winnie Z Long, Sukrit Singh, Kathryn Burnett, Greg L Hura, Jay C Nix, Gregory R Bowman, Tom Ellenberger, John A Tainer
Apoptosis-inducing factor (AIF) is critical for mitochondrial respiratory complex biogenesis and for mediating necroptotic parthanatos; these functions are seemingly regulated by enigmatic allosteric switching driven by NADH charge-transfer complex (CTC) formation. Here, we define molecular pathways linking AIF's active site to allosteric switching regions by characterizing dimer-permissive mutants using small-angle X-ray scattering (SAXS) and crystallography and by probing AIF-CTC communication networks using molecular dynamics simulations...
November 2, 2016: Structure
https://www.readbyqxmd.com/read/27810330/foxl2-402c-g-mutation-can-be-identified-in-the-circulating-tumor-dna-of-patients-with-adult-granulosa-cell-tumors
#13
Anniina Färkkilä, Melissa K McConechy, Winnie Yang, Aline Talhouk, Ying Ng, Amy Lum, Ryan D Morin, Kevin Bushell, Annika Riska, Jessica N McAlpine, C Blake Gilks, Leila Unkila-Kallio, Mikko Anttonen, David G Huntsman
Adult granulosa cell tumors (AGCTs) of the ovary are molecularly characterized by the pathognomonic FOXL2 402C>G (C134W) mutation. To improve diagnostics and follow-up, we developed a specific digital droplet PCR (ddPCR) assay to detect the FOXL2 mutation in the circulating tumor DNA (ctDNA) of AGCT patients. Optimization of the ddPCR assay was performed using a TaqMan primer/probe with the RainDance RainDrop digital PCR system. The ddPCR assay was performed on circulating cell-free DNA extracted from 120 serial plasma samples collected prospectively from 35 AGCT patients...
October 31, 2016: Journal of Molecular Diagnostics: JMD
https://www.readbyqxmd.com/read/27802246/morphometry-analysis-of-basal-ganglia-structures-in-children-with-obstructive-sleep%C3%A2-apnea
#14
Jian Lv, Lin Shi, Lei Zhao, Jian Weng, Vincent C T Mok, Winnie C W Chu, Defeng Wang
BACKGROUND: Obstructive sleep apnea (OSA) affects both adults and children, likely mediated by the deficits of various brain regions. The association between structural alterations in the brain and OSA syndrome have been reported in adult patients, but the corresponding evidence for OSA children is still limited. OBJECTIVE: The proposed study aimed to investigate the structural alterations in the brain of children with OSA, with focus on basal ganglia structures...
October 6, 2016: Journal of X-ray Science and Technology
https://www.readbyqxmd.com/read/27800519/clofazimine-enteropathy-a-rare-and-underrecognized-complication-of-mycobacterial-therapy
#15
Winnie Szeto, Monica T Garcia-Buitrago, Lilian Abbo, Joseph D Rosenblatt, Baharak Moshiree, Michele I Morris
Clofazimine-induced crystal-storing histiocytosis is a rare complication of treatment previously reported in dermatology literature as a complication of leprosy therapy. We report a case of disseminated Mycobacterium abscessus requiring treatment with high-dose oral clofazimine resulting in enteropathy in a patient who presented with abdominal pain, malnutrition, and melena.
September 2016: Open Forum Infectious Diseases
https://www.readbyqxmd.com/read/27795375/evaluating-polymyxin-b-based-combinations-against-carbapenem-resistant-escherichia-coli-in-time-kill-studies-and-in-a-hollow-fiber-infection-model
#16
Yiying Cai, Tze-Peng Lim, Jocelyn Teo, Suranthran Sasikala, Eric Chun Yong Chan, Yan Jun Hong, Winnie Lee, Thean Yen Tan, Thuan Tong Tan, Tse Hsien Koh, Li Yang Hsu, Andrea L Kwa
OBJECTIVES: Polymyxin B-based combinations have emerged as a mainstay treatment against carbapenem-resistant Escherichia coli (CREC). We investigated the activity of polymyxin B-based two-antibiotic combinations against CREC using time-kill studies (TKS) and validated the findings in a hollow fiber infection model (HFIM). METHODS: TKS was conducted using 5 clinical CREC strains at 5 log10 CFU/mL against 10 polymyxin B-based two-antibiotic combinations at maximum clinically achievable concentrations...
October 17, 2016: Antimicrobial Agents and Chemotherapy
https://www.readbyqxmd.com/read/27789043/comparison-of-adherence-to-rivaroxaban-versus-apixaban-among-patients-with-atrial-fibrillation
#17
Colleen A McHorney, Eric D Peterson, François Laliberté, Guillaume Germain, Winnie W Nelson, Concetta Crivera, Jeffrey Schein, Patrick Lefebvre
PURPOSE: Non-vitamin K antagonist oral anticoagulant medications are increasingly used for stroke prophylaxis in patients with nonvalvular atrial fibrillation (NVAF). This study aimed to compare adherence with rivaroxaban and apixaban among patients with NVAF in routine clinical practice. METHODS: Using pharmacy and medical claims from Truven Health Analytics MarketScan databases, we identified NVAF patients aged ≥18 years treated with rivaroxaban or apixaban...
October 24, 2016: Clinical Therapeutics
https://www.readbyqxmd.com/read/27785001/effects-of-a-tailor-made-exercise-program-on-exercise-adherence-and-health-outcomes-in-patients-with-knee-osteoarthritis-a-mixed-methods-pilot-study
#18
Fung-Kam Iris Lee, Tze-Fan Diana Lee, Winnie Kwok-Wei So
INTRODUCTION: Previous studies showed that exercise intervention was effective in symptoms control of knee osteoarthritis (OA) but poor intervention adherence reduced the exercise effect. It has been suspected that the design of exercise intervention mainly from the health care professionals' perspective could not address the patients' barriers to exercise. Therefore, a tailor-made exercise program which incorporated the patient's perspective in the design was developed and ready for evaluation...
2016: Clinical Interventions in Aging
https://www.readbyqxmd.com/read/27780397/healthcare-costs-associated-with-rivaroxaban-or-warfarin-use-for-the-treatment-of-venous-thromboembolism
#19
Craig I Coleman, Christopher Baugh, Concetta Crivera, Dejan Milentijevic, Sheng-Wei Wang, Lang Lu, Winnie W Nelson
INTRODUCTION: Rivaroxaban has been shown to have similar efficacy but less major bleeding than warfarin in randomized trials of patients experiencing venous thromboembolism (VTE). This report sought to assess healthcare costs up to 12-months following an index VTE in patients prescribed either rivaroxaban or warfarin. MATERIALS AND METHODS: This study analyzed claims from the MarketScan Commercial Claims and Encounters Database from November 2011-July 2015. It selected adults newly-diagnosed with VTE (deep vein thrombosis [DVT] or pulmonary embolism [PE]) if they had an outpatient prescription claim for rivaroxaban or warfarin within 7-days of the index event...
October 26, 2016: Journal of Medical Economics
https://www.readbyqxmd.com/read/27780192/pathogenesis-and-progression-of-oesophageal-adenocarcinoma-varies-by-prior-diagnosis-of-barrett-s-oesophagus
#20
Michael B Cook, Jennifer Drahos, Shannon Wood, Lindsey Enewold, Ruth Parsons, Neal D Freedman, Philip R Taylor, Winnie Ricker, Christian C Abnet
BACKGROUND: The absolute risk of oesophageal adenocarcinoma (EA) among individuals with Barrett's oesophagus (BE) is low and a majority of EA cases are diagnosed among individuals with no prior BE diagnosis. To ensure that insights from EA case-control studies are transferable to clinical management of BE populations, we conducted a case-case study to compare the clinical presentation, medical history and survival of EA cases with and without a prior BE diagnosis in the Surveillance, Epidemiology and End Results Medicare database...
November 22, 2016: British Journal of Cancer
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