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https://www.readbyqxmd.com/read/29454097/improving-sustained-drug-delivery-from-ophthalmic-lens-materials-through-the-control-of-temperature-and-time-of-loading
#1
Ana Topete, Andreia S Oliveira, A Fernandes, T G Nunes, A P Serro, B Saramago
Although the possibility of using drug-loaded ophthalmic lens to promote sustained drug release has been thoroughly pursued, there are still problems to be solved associated to the different alternatives. In this work, we went back to the traditional method of drug loading by soaking in the drug solution and tried to optimize the release profiles by changing the temperature and the time of loading. Two materials commercially available under the names of CI26Y and Definitive 50 were chosen. CI26Y is used for intraocular lenses (IOLs) and Definitive 50 for soft contact lenses (SCLs)...
February 14, 2018: European Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/29445872/bowman-layer-transplantation-5-year-results
#2
Korine van Dijk, Jack S Parker, Lamis Baydoun, Abbas Ilyas, Isabel Dapena, Esther A Groeneveld-van Beek, Gerrit R J Melles
PURPOSE: The purpose of this study was to evaluate the 5-year clinical results of isolated Bowman layer (BL) transplantation in the treatment of advanced keratoconus. METHODS: In this prospective, single-center, interventional case series at a tertiary referral center, 20 eyes of 17 patients with advanced keratoconus underwent BL transplantation, i.e. an isolated Bowman layer graft was positioned into a manually dissected mid-stromal pocket. Scheimpflug-based corneal tomography measurements, best corrected spectacle and contact lens visual acuities (BSCVA and BCLVA), endothelial cell density, and complications were evaluated up to 5 years after surgery...
February 14, 2018: Graefe's Archive for Clinical and Experimental Ophthalmology
https://www.readbyqxmd.com/read/29438121/comparison-of-the-lotrafilcon-b-and-comfilcon-a-silicone-hydrogel-bandage-contact-lens-on-postoperative-ocular-discomfort-after-photorefractive-keratectomy
#3
Mehrdad Mohammadpour, Zahra Heidari, Hassan Hashemi, Soheila Asgari
OBJECTIVES: To compare the lotrafilcon B and comfilcon A silicone hydrogel bandage contact lenses after photorefractive keratectomy (PRK). METHODS: One hundred twenty eyes of 60 patients who underwent PRK were included in this randomized clinical trial study. In the end of the surgery, the lotrafilcon B (Air Optix; Ciba Vision, Duluth, GA) was used in one eye and the comfilcon A (Biofinity; Coopervision, Fairport, NY) was used in the fellow eye randomly. Pain and discomfort were assessed on the first and third day after surgery by visual analogue scale...
February 12, 2018: Eye & Contact Lens
https://www.readbyqxmd.com/read/29438120/misight-assessment-study-spain-adverse-events-tear-film-osmolarity-and-discontinuations
#4
Alicia Ruiz-Pomeda, Belén Pérez-Sánchez, Francisco L Prieto-Garrido, Ramón Gutiérrez-Ortega, César Villa-Collar
OBJECTIVES: To assess the relative clinical success of MiSight contact lenses (CLs) (study group) and distance single-vision (SV) spectacles (control group) in children in terms of adverse events (AEs), discontinuations, and tear film osmolarity over a 2-year period. METHODS: Seventy-four subjects aged 8 to 12 with myopia of -0.75 to -4.00 D and astigmatism less than 1.00 D were randomly assigned to MiSight CLs or SV groups. Subjects were monitored at 6-month intervals over the course of 24 months and advised to report to the clinic immediately should AEs occur...
February 12, 2018: Eye & Contact Lens
https://www.readbyqxmd.com/read/29436623/development-of-uracil-dna-glycosylase-supplemented-loop-mediated-isothermal-amplification-coupled-with-nanogold-probe-udg-lamp-aunp-for-specific-detection-of-pseudomonas%C3%A2-aeruginosa
#5
Orapan Manajit, Siwaporn Longyant, Paisarn Sithigorngul, Parin Chaivisuthangkura
Pseudomonas aeruginosa (P. aeruginosa) is an important opportunistic pathogen that causes serious infections in humans, including keratitis in contact lens wearers. Therefore, establishing a rapid, specific and sensitive method for the identification of P. aeruginosa is imperative. In the present study, the uracil-DNA-glycosylase-supplemented loop-mediated isothermal amplification combined with nanogold labeled hybridization probe (UDG-LAMP-AuNP) was developed for the detection of P. aeruginosa. UDG-LAMP was performed to prevent carry over contamination and the LAMP reactions can be readily observed using the nanogold probe...
February 2, 2018: Molecular Medicine Reports
https://www.readbyqxmd.com/read/29432780/how-mechanical-forces-shape-the-developing-eye
#6
REVIEW
Hadi S Hosseini, Larry A Taber
In the vertebrate embryo, the eyes develop from optic vesicles that grow laterally outward from the brain tube and contact the overlying surface ectoderm. Within the region of contact, each optic vesicle and the surface ectoderm thicken to form placodes, which then invaginate to create the optic cup and lens pit, respectively. Eventually, the optic cup becomes the retina, while the lens pit closes to form the lens vesicle. Here, we review current hypotheses for the physical mechanisms that create these structures and present novel three-dimensional computer (finite-element) models to illustrate the plausibility and limitations of these hypotheses...
February 9, 2018: Progress in Biophysics and Molecular Biology
https://www.readbyqxmd.com/read/29426803/performance-evaluation-of-delefilcon-a-water-gradient-daily-disposable-contact-lenses-in-first-time-contact-lens-wearers
#7
Sebastian Marx, Bo Lauenborg, Jami R Kern
PURPOSE: To evaluate the tolerability of and subject and investigator satisfaction with delefilcon A (DAILIES TOTAL1®) daily disposable contact lenses in first-time contact lens wearers. METHODS: This European multicenter, open-label, single-arm, two-week trial enrolled first-time contact lens wearers and fitted them with delefilcon A contact lenses. Assessments were made at dispensing and at Weeks 1 and 2. Subject-reported outcomes included comfort, quality of vision, convenience, and intent to purchase, which were ranked by agreement responses...
February 6, 2018: Contact Lens & Anterior Eye: the Journal of the British Contact Lens Association
https://www.readbyqxmd.com/read/29426444/eyeprintpro-therapeutic-scleral-contact-lens-indications-and-outcomes
#8
Michael T B Nguyen, Vishakha Thakrar, Clara C Chan
OBJECTIVE: To describe indications and outcomes of patients fitted with the EyePrintPRO therapeutic scleral lens. METHODS: A database search of patients fitted with the EyePrintPRO from 2014 to 2016. Fourteen eyes of 10 patients were reviewed retrospectively. Patient demographics, medical and ocular history, indications for fitting, duration of wear, symptoms, and best-corrected visual acuity (BCVA) were analyzed. RESULTS: Mean age at lens fitting was 49 years (range, 21-67 years)...
February 2018: Canadian Journal of Ophthalmology. Journal Canadien D'ophtalmologie
https://www.readbyqxmd.com/read/29424828/subjective-ratings-and-satisfaction-in-contact-lens-wear
#9
Jennie Diec, Thomas Naduvilath, Daniel Tilia
SIGNIFICANCE: This study shows satisfaction in contact lens (CL) wear is influenced by both comfort and vision. Eighty-six percent of participants were willing to continue with trial CL wear if satisfied with both comfort and vision, dropping to 50% if either variable was unsatisfactory and 0% if both were unsatisfactory. PURPOSE: The aim of this study was to understand the relationship between subjective ratings and satisfaction with CL wear. METHODS: This was a retrospective analysis of two daily-disposable CL trials (delefilcon A, somofilcon A) on participants 40 years or younger followed over 3 months...
February 8, 2018: Optometry and Vision Science: Official Publication of the American Academy of Optometry
https://www.readbyqxmd.com/read/29423513/association-of-contact-lens-adherence-with-visual-outcome-in-the-infant-aphakia-treatment-study-a-secondary-analysis-of-a-randomized-clinical-trial
#10
Caroline H Cromelin, Carolyn Drews-Botsch, Buddy Russell, Scott R Lambert
Importance: Although contact lenses have been used for decades to optically correct eyes in children after cataract surgery, there has never been a prospective study looking at contact lens adherence in children with aphakia, to our knowledge. Objective: To evaluate contact lens adherence and its association with visual outcome in a cohort of children treated for unilateral cataract surgery. Design, Setting, and Participants: Secondary analysis of a multicenter randomized clinical trial of 57 infants born from August 22, 2004, to April 25, 2008, who were randomized to 1 of 2 treatments and followed up to age 5 years...
February 8, 2018: JAMA Ophthalmology
https://www.readbyqxmd.com/read/29423211/depressive-affect-in-incident-hemodialysis-patients
#11
Kathryn A McDougall, John W Larkin, Rebecca L Wingard, Yue Jiao, Sophia Rosen, Lin Ma, Len A Usvyat, Franklin W Maddux
Background: The prevalence of depressive affect is not well defined in the incident hemodialysis (HD) population. We investigated the prevalence of and associated risk factors and hospitalization rates for depressive affect in incident HD patients. Methods: We performed a prospective investigation using the Patient Health Questionnaire 2 (PHQ2) depressive affect assessment. From January to July of 2013 at 108 in-center clinics randomly selected across tertiles of baseline quality measures, we contacted 577 and 543 patients by telephone for depressive affect screening...
February 2018: Clinical Kidney Journal
https://www.readbyqxmd.com/read/29422767/acceleration-of-the-formation-of-biofilms-on-contact-lens-surfaces-in-the-presence-of-neutrophil-derived-cellular-debris-is-conserved-across-multiple-genera
#12
Naiya B Patel, Jorge A Hinojosa, Meifang Zhu, Danielle M Robertson
Purpose: We have previously shown that invasive strains of Pseudomonas aeruginosa exploit the robust neutrophil response to form biofilms on contact lens surfaces and invade the corneal epithelium. The present study investigated the ability of multiple bacterial genera, all commonly recovered during contact lens-related infectious events, to adhere to and form biofilms on contact lens surfaces in the presence of neutrophils. Methods: Five reference strains from the American Type Culture Collection were used: P...
2018: Molecular Vision
https://www.readbyqxmd.com/read/29417444/corneal-perforation-after-noncontact-tonometry-in-patients-with-active-recurrent-herpes-simplex-keratitis-case-report
#13
Napaporn Tananuvat, Atitaya Apivatthakakul, Chulaluck Tangmonkongvoragul
PURPOSE: To report iatrogenic complications and to review the potential complications caused by noncontact tonometry (NCT) in related literature. METHODS: This case report describes two cases of active recurrent herpes simplex keratitis (HSK) on top of a thin corneal scar. The cornea was perforated by the air pulse from the NCT, resulting in an air bubble in the anterior chamber. RESULTS: Both patients were diagnosed with active recurrent necrotizing stromal HSK on top of a thinned corneal scar after previous therapeutic treatment involving tissue adhesive glue with a bandage contact lens (BCL) to treat a perforated cornea...
February 7, 2018: International Ophthalmology
https://www.readbyqxmd.com/read/29412494/the-rising-tide-of-acanthamoeba-keratitis-in-auckland-new-zealand-a-7-year-review-of-presentation-diagnosis-and-outcomes-2009-2016
#14
James McKelvie, Moaz Alshiakhi, Mohammed Ziaei, Dipika V Patel, Charles Nj McGhee
IMPORTANCE: Acanthamoeba is an increasingly prevalent cause of vision-threatening microbial keratitis. BACKGROUND: To assess the incidence, clinical presentation, diagnosis and outcomes of patients with Acanthamoeba keratitis (AK) in Auckland, New Zealand over a 7-year period. DESIGN: Retrospective observational consecutive case series. PARTICIPANTS: Fifty-eight eyes of 52 patients diagnosed with AK. METHODS: All cases of AK were identified using a cross-referenced search of clinical, laboratory and pharmacy records from March 2009 to May 2016...
February 7, 2018: Clinical & Experimental Ophthalmology
https://www.readbyqxmd.com/read/29411497/the-effects-of-two-different-types-of-bandage-contact-lenses-on-the-healthy-canine-eye
#15
Barbara Katharina Braus, Daniela Riedler, Alexander Tichy, Joachim Spergser, Ilse Schwendenwein
OBJECTIVE: To compare two types of bandage contact lenses on the healthy canine eye. ANIMALS STUDIED: Six healthy Beagles. PROCEDURES: Two different types of bandage contact lenses (single sized human silicone contact lens 'PureVision 2' (Bausch & Lomb Incorporated, Rochester, NY, USA) and specially designed veterinary hydrogel contact lens 'AcriVet Pat D' (Bausch & Lomb Incorporated) were placed in 12 eyes of healthy Beagle dogs. Retention times and the effects of the lenses regarding irritation of the eye, changes in tear production, impact of contact lenses on tonometric readings, and cytologic and microbiological alterations of the canine eye were investigated...
February 6, 2018: Veterinary Ophthalmology
https://www.readbyqxmd.com/read/29408828/clinical-features-antibiotic-susceptibility-profile-and-outcomes-of-infectious-keratitis-caused-by-stenotrophomonas-maltophilia
#16
Sotiria Palioura, Allister Gibbons, Darlene Miller, Terrence P OʼBrien, Eduardo C Alfonso, Oriel Spierer
PURPOSE: Stenotrophomonas maltophilia, an uncommon cause of infectious keratitis, is difficult to treat because of its resistance to multiple antibiotics. The purpose of this study is to describe the clinical features, antibiotic susceptibility profile, and outcomes of S. maltophilia keratitis. METHODS: A retrospective review of records from 1987 to 2016 identified 26 eyes of 26 patients who were treated at the Bascom Palmer Eye Institute for an S. maltophilia corneal ulcer...
March 2018: Cornea
https://www.readbyqxmd.com/read/29408827/corneal-optical-changes-associated-with-induced-edema-in-fuchs-endothelial-corneal-dystrophy
#17
Katrin Wacker, Jay W McLaren, Katrina M Kane, Sanjay V Patel
PURPOSE: Patients with Fuchs endothelial corneal dystrophy (FECD) often notice poor vision in the morning that improves as the day progresses. In this study, we determined changes in corneal optical properties associated with induced corneal edema. METHODS: Twenty-three phakic eyes (23 participants) with FECD (grades 1-6, modified Krachmer scale) and 8 normal eyes (8 participants) were examined by Scheimpflug photography. Central corneal thickness, high-order aberrations from anterior and posterior corneal surfaces, and backscatter from the anterior, mid-, and posterior cornea were determined from the Scheimpflug images...
March 2018: Cornea
https://www.readbyqxmd.com/read/29401882/optical-design-of-soft-multifocal-contact-lens-with-uniform-optical-power-in-center-distance-zone-with-optimized-nurbs
#18
Lien T Vu, Chao-Chang A Chen, Chia-Wei Yu
This study aims to develop a new optical design method of soft multifocal contact lens (CLs) to obtain uniform optical power in large center-distance zone with optimized Non-Uniform Rational B-spline (NURBS). For the anterior surface profiles of CLs, the NURBS design curves are optimized to match given optical power distributions. Then, the NURBS in the center-distance zones are fitted in the corresponding spherical/aspheric curves for both data points and their centers of curvature to achieve the uniform power...
February 5, 2018: Optics Express
https://www.readbyqxmd.com/read/29398904/a-single-vectored-thermal-pulsation-treatment-for-meibomian-gland-dysfunction-increases-mean-comfortable-contact-lens-wearing-time-by-approximately-4-hours-per-day
#19
Caroline A Blackie, Christy A Coleman, Kelly K Nichols, Lyndon Jones, Peter Q Chen, Ron Melton, David L Kading, Leslie E O'Dell, Sruthi Srinivasan
Purpose: To evaluate the effect of a single vectored thermal pulsation (VTP) treatment in contact lens wearers with meibomian gland dysfunction (MGD) and dry eye symptoms. Methods: The prospective, nonsignificant risk, open-label, randomized, multi-center clinical trial included 55 soft contact lens (SCL) wearers with MGD and evaporative dry eye. Subjects were randomized to the single VTP treatment group or an untreated control. The controls received a crossover VTP treatment at 3 months (crossover treatment group)...
2018: Clinical Ophthalmology
https://www.readbyqxmd.com/read/29398334/visual-quality-with-corneo-scleral-contact-lenses-for-keratoconus-management
#20
Juan Carlos Montalt, Esteban Porcar, Enrique España-Gregori, Cristina Peris-Martínez
PURPOSE: To assess the visual quality achieved by fitting corneo-scleral contact lenses (CScL) for keratoconus management. METHODS: Thirty patients with keratoconus presented to have CScL fitted because of the unsatisfactory visual quality they experienced with their contact lenses or spectacles. The eye examination included visual acuity assessment, anterior eye biomicroscopy, ocular fundus examination, corneal topographic analysis, endothelial-cell count, contrast sensitivity and aberrometry...
February 2, 2018: Contact Lens & Anterior Eye: the Journal of the British Contact Lens Association
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