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https://www.readbyqxmd.com/read/28633591/approaches-in-topical-ocular-drug-delivery-and-developments-in-the-use-of-contact-lenses-as-drug-delivery-devices
#1
Prina Mehta, Rita Haj-Ahmad, Ali Al-Kinani, Muhammad Sohail Arshad, Ming-Wei Chang, Raid G Alany, Zeeshan Ahmad
Drug-delivery approaches have diversified over the last two decades with the emergence of nanotechnologies, smart polymeric systems and multimodal functionalities. The intended target for specific treatment of disease is the key defining developing parameter. One such area which has undergone significant advancements relates to ocular delivery. This has been expedited by the development of material advancement, mechanistic concepts and through the deployment of advanced process technologies. This review will focus on the developments within lens-based drug delivery while touching on conventional and current methods of topical ocular drug delivery...
July 2017: Therapeutic Delivery
https://www.readbyqxmd.com/read/28632093/allergic-contact-dermatitis-from-ophthalmics
#2
Yue Zheng, Paru R Chaudhari, Howard I Maibach
In this article we summarize the recently described allergens responsible for allergic contact dermatitis due to ophthalmic drugs and contact lens solutions, and emphaage the need on how to perform diagnostic testing in this special clinical entity.
March 6, 2017: Cutaneous and Ocular Toxicology
https://www.readbyqxmd.com/read/28630786/ophthoselfie-detailed-self-imaging-of-cornea-and-anterior-segment-by-smartphone
#3
Abdullah Kaya
OBJECTIVES: To describe the ophthoselfie, a method by which everyone can take detailed self-images of the cornea and anterior segment with a smartphone. MATERIALS AND METHODS: A 90-diopter non-contact double aspheric lens was attached to posterior camera of the smartphone by clear tape. Images of one eye on the screen of the smartphone could be seen with the other eye in the mirror and images were taken. RESULTS: Accurate and detailed images of the cornea and anterior segment of the eye could be taken...
June 2017: Turkish Journal of Ophthalmology
https://www.readbyqxmd.com/read/28629349/relationships-between-dental-personnel-and-non-dental-primary-health-care-providers-in-rural-and-remote-queensland-australia-dental-perspectives
#4
Jackie Stuart, Ha Hoang, Len Crocombe, Tony Barnett
BACKGROUND: Collaboration between dental practitioners and non-dental primary care providers has the potential to improve oral health care for people in rural and remote communities, where access to oral health services is limited. However, there is limited research on collaboration between these professional disciplines. The purpose of this paper was to explore the relationships between dental practitioners and non-dental primary care providers from rural and remote areas of Queensland and to identify strategies that could improve collaboration between these disciplines from the perspective of dental participants...
June 19, 2017: BMC Oral Health
https://www.readbyqxmd.com/read/28627456/effect-of-the-surface-layer-on-drug-release-from-delefilcon-a-dailies-total1-%C3%A2-contact-lenses
#5
Phillip Dixon, Anuj Chauhan
Contact lenses are receiving significant attention for delivering ophthalmic drugs with higher bioavailability compared to eye drops. Here we explore drug transport from delefilcon-A Dailies Total1(®) lenses which are designed to have a thin, high-water content layer on the surface. Our goal is to determine the impact of this high water content layer on drug transport for both hydrophobic (dexamethasone and cyclosporine) and hydrophilic (timolol and levofloxacin) drugs. Drugs were loaded into the lens by soaking in aqueous drug solutions till equilibrium, followed by release in phosphate buffered saline...
June 13, 2017: International Journal of Pharmaceutics
https://www.readbyqxmd.com/read/28626819/comparison-of-bandage-contact-lens-removal-on-the-fourth-versus-seventh-postoperative-day-after-photorefractive-keratectomy-a-randomized-clinical-trial
#6
Mehrdad Mohammadpour, Delaram Shakoor, Hassan Hashemi, Mohamad Aghaie Meybodi, Fateme Rajabi, Pegah Hosseini
PURPOSE: To compare the outcomes of bandage contact lens (BCL) removal on the fourth versus seventh post-operative day following photorefractive keratectomy (PRK). METHODS: This study recruited eyes of patients who underwent PRK surgery. The patients were randomly assigned to 2 groups. In Group 1 BCL was removed on the 4th postoperative day, while in Group 2, BCL was removed on the 7th postoperative day. After BCL removal, patients were asked to express their pain score and eye discomfort...
June 2017: Journal of Current Ophthalmology
https://www.readbyqxmd.com/read/28625688/electrically-atomised-formulations-of-timolol-maleate-for-direct-and-on-demand-ocular-lens-coatings
#7
Prina Mehta, Ali Al-Kinani, Rita Haj-Ahmad, Muhammad Sohail Arshad, Ming-Wei Chang, G Raid Alany, Zeeshan Ahmad
Advances in nanotechnology have enabled solutions for challenging drug delivery targets. While the eye presents numerous emerging opportunities for delivery, analysis and sensing; issues persist for conventional applications. This includes liquid phase formulation localisation on the ocular surface once administered as formulated eye-drops; with the vast majority of dosage (>90%) escaping from the administered site due to tear production and various drainage mechanisms. The work presented here demonstrates a single needle electrohydrodynamic (EHD) engineering process to nano-coat (as an on demand and controllable fiber depositing method) the surface of multiple contact lenses rendering formulations to be stationary on the lens and at the bio-interface...
June 15, 2017: European Journal of Pharmaceutics and Biopharmaceutics
https://www.readbyqxmd.com/read/28624312/non-lens-based-surgical-techniques-for-presbyopia-correction
#8
R Bilbao-Calabuig, F Llovet-Osuna
INTRODUCTION: Presbyopia is the most prevalent refractive error. With a progressive aging population, its surgical correction is an important challenge for the ophthalmology community, as well as the millions of patients who suffer from it, and who are increasingly demanding alternatives to its correction with glasses or contact lenses. MATERIAL AND METHODS: A review is presented with a synthesised discussion on the pathophysiological theories of presbyopia and an updated and analytical description of the non-lens involvement surgical techniques used to treat presbyopia...
June 14, 2017: Archivos de la Sociedad Española de Oftalmología
https://www.readbyqxmd.com/read/28624168/antibiotic-prescription-fills-for-acute-conjunctivitis-among-enrollees-in-a-large-united-states-managed-care-network
#9
Nakul S Shekhawat, Roni M Shtein, Taylor S Blachley, Joshua D Stein
PURPOSE: Antibiotics are seldom necessary to treat acute conjunctivitis. We assessed how frequently patients with newly diagnosed acute conjunctivitis fill prescriptions for topical antibiotics and factors associated with antibiotic prescription fills. DESIGN: Retrospective, observational cohort study. PARTICIPANTS: A total of 340 372 enrollees in a large nationwide United States managed care network with newly diagnosed acute conjunctivitis, from 2001 through 2014...
June 14, 2017: Ophthalmology
https://www.readbyqxmd.com/read/28619486/extended-depth-of-focus-contact-lenses-vs-two-commercial-multifocals-part-2-visual-performance-after-1-week-of-lens-wear
#10
Ravi C Bakaraju, Daniel Tilia, Jennifer Sha, Jennie Diec, Jiyoon Chung, Danny Kho, Shona Delaney, Anna Munro, Varghese Thomas
PURPOSE: To compare the visual performance of prototype contact lenses designed via deliberate manipulation of higher-order spherical aberrations to extend-depth-of-focus with two commercial multifocals, after 1 week of lens wear. METHODS: In a prospective, participant-masked, cross-over, randomized, 1-week dispensing clinical-trial, 43 presbyopes [age: 42-63 years] each wore AIROPTIX Aqua multifocal (AOMF), ACUVUE OASYS for presbyopia (AOP) and extended-depth-of-focus prototypes (EDOF) appropriate to their add requirements...
June 12, 2017: Journal of Optometry
https://www.readbyqxmd.com/read/28617731/retention-rates-in-new-contact-lens-wearers
#11
Anna Sulley, Graeme Young, Chris Hunt, Sarah McCready, Marie-Therese Targett, Ruth Craven
PURPOSE: To determine the retention rate (RR) for neophyte patients fitted with contact lenses (CLs) and to identify factors associated with retention and dropout. METHOD: This multisite, sponsor-masked registry study evaluated the 1-year status of neophyte CL wearers fitted in a representative range of UK practices. A total of 26 UK investigational sites each recruited up to 89 neophyte patients. The participants were requested to complete surveys at 1 month (±1 week from date of fitting), 3 months (±2 weeks), and 12 months (±3 weeks) online or through phone...
June 14, 2017: Eye & Contact Lens
https://www.readbyqxmd.com/read/28617725/depth-profile-assessment-of-the-early-phase-deposition-of-lysozyme-on-soft-contact-lens-materials-using-a-novel-in-vitro-eye-model
#12
Han Qiao, Chau-Minh Phan, Hendrik Walther, Lakshman N Subbaraman, Lyndon Jones
OBJECTIVE: To characterize the location of fluorescently labeled lysozyme on commercial contact lenses (CLs) using an in vitro eye model that simulates tear volume, tear flow, air exposure, and mechanical wear. METHODS: One commercially available conventional hydrogel CL material (etafilcon A) and three silicone hydrogel CL materials (balafilcon A, lotrafilcon B, and senofilcon A) were evaluated in this study. The CLs were mounted on the in vitro eye model and exposed to artificial tear fluid containing fluorescein isothiocyanate (FITC)-labeled lysozyme for 2 and 10 hrs...
June 14, 2017: Eye & Contact Lens
https://www.readbyqxmd.com/read/28612422/tenonplasty-for-closing-defects-during-sclerocorneal-surgery-a-brief-review-of-its-anatomy-and-clinical-applications
#13
Fabian N Fries, Shady Suffo, Loay Daas, Berthold Seitz, Miltiadis Fiorentzis, Arne Viestenz
PURPOSE: To provide insight into the clinical anatomy of Tenon's capsule and to describe a technique to manage sclerocorneal defects using autologous Tenon's tissue. METHODS: A thin layer of Tenon's capsule harvested from the patient's own eye is used to seal the defect and act as a scaffold. The Tenon's flap is spread over the defect and held in place by Vicryl sutures. A bandage contact lens is then placed on the eye. RESULTS: Tenon's capsule is composed of thick fibrous tissue with smooth muscle fibers and a thin posterior capsule of orbital fat...
June 13, 2017: Clinical Anatomy
https://www.readbyqxmd.com/read/28606616/the-effect-of-previous-soft-contact-lens-wear-on-corneal-refractive-surgery-outcomes
#14
Aoife Lloyd-McKernan, Luisa Simo Mannion, Veronica O'Dwyer
PURPOSE: To examine the influence of previous soft contact lens (SCL) wear on corneal refractive surgery (CRS) outcomes when SCL wear is ceased for two weeks versus twenty-four hours, and also when compared to no wear, prior to CRS. METHODS: A retrospective examination of CRS patient records was carried out for two groups of patients- who ceased SCL wear for two weeks (n=45) and for twenty-four hours (n=49) prior to CRS and compared to a non-contact lens (NCL) control group (n=45 and n=49, respectively)...
June 10, 2017: Contact Lens & Anterior Eye: the Journal of the British Contact Lens Association
https://www.readbyqxmd.com/read/28606456/extended-depth-of-focus-contact-lenses-vs-two-commercial-multifocals-part-1-optical-performance-evaluation-via-computed-through-focus-retinal-image-quality-metrics
#15
Ravi C Bakaraju, Klaus Ehrmann, Arthur Ho
PURPOSE: To compare the computed optical performance of prototype lenses designed using deliberate manipulation of higher-order spherical aberrations to extend depth-of-focus (EDOF) with two commercial multifocals. METHODS: Emmetropic, presbyopic, schematic eyes were coupled with prototype EDOF and commercial multifocal lenses (Acuvue Oasys for presbyopia, AOP, Johnson & Johnson & Air Optix Aqua multifocal, AOMF, Alcon). For each test configuration, the through-focus retinal image quality (TFRIQ) values were computed over 21 vergences, ranging from -0...
June 9, 2017: Journal of Optometry
https://www.readbyqxmd.com/read/28602547/non-invasive-objective-and-contemporary-methods-for-measuring-ocular-surface-inflammation-in-soft-contact-lens-wearers-a-review
#16
REVIEW
Cecilia Chao, Kathryn Richdale, Isabelle Jalbert, Kim Doung, Moneisha Gokhale
Contact lens wear is one of the primary risk factors for the development of ocular surface inflammatory events. The purpose of this review is to examine and summarize existing knowledge on the mechanisms of contact lens related ocular surface inflammation and the evidence for the effectiveness of current objective methods to measure ocular surface inflammation. Contact lens wear is postulated to trigger an inflammatory response on the ocular surface due to mechanical, chemical, hypoxic stress, or by the introduction of microbes and their toxins...
June 8, 2017: Contact Lens & Anterior Eye: the Journal of the British Contact Lens Association
https://www.readbyqxmd.com/read/28597930/infection-control-guidelines-for-optometrists-2016
#17
Ka-Yee Lian, Genevieve Napper, Fiona J Stapleton, Patricia M Kiely
BACKGROUND: This paper provides an updated version of the paper: Infection control guidelines for optometrists 2007. METHODS: Information from peer-reviewed journal articles, guidelines from professional societies, and government health department and other websites and instructions from equipment manufacturers were considered in determining infection risk factors in optometric practice. They were used to revise the recommendations on disinfection, sterilisation and reprocessing procedures for instrumentation and other equipment used in optometric practice as well as personal infection control measures to be undertaken by staff...
June 9, 2017: Clinical & Experimental Optometry: Journal of the Australian Optometrical Association
https://www.readbyqxmd.com/read/28597601/endothelial-alterations-in-712-keratoconus-patients
#18
Susanne Goebels, Timo Eppig, Berthold Seitz, Nòra Szentmàry, Alan Cayless, Achim Langenbucher
PURPOSE: To investigate the effect of the severity of keratoconus on the corneal endothelium using specular microscopy. METHODS: Seven hundred and twelve eyes from the Homburg Keratoconus Center (HKC) database were included in this retrospective study. Corneal endothelium was evaluated using the Tomey EM-3000 specular microscope. Keratoconus-related topographic and tomographic data were obtained from Scheimpflug-based tomography (Oculus Pentacam(®) HR). Eyes were classified into stages 0 (healthy) to 4 (severe keratoconus) according to the Topographic Keratoconus Classification (TKC)...
June 9, 2017: Acta Ophthalmologica
https://www.readbyqxmd.com/read/28586914/visual-performance-and-optical-quality-of-standardized-asymmetric-soft-contact-lenses-in-patients-with-keratoconus
#19
Asaki Suzaki, Naoyuki Maeda, Mutsumi Fuchihata, Shizuka Koh, Kohji Nishida, Takashi Fujikado
Purpose: To evaluate the visual performance and optical quality of a standardized asymmetric soft contact lens (SCL) used for correction of higher-order aberrations (HOAs) in eyes with keratoconus. Methods: We included 30 eyes (26 patients) with keratoconus (average K: 45.7 ± 2.3 diopters [D]). The patients were subjected to corneal tomography, aberrometry, measurements of manifest refraction and visual acuity (VA), and visual analog scale (VAS) assessments. The study lenses were made using a molding method and consisted of six standardized types, in which an asymmetric power distribution of approximately 2 to 12 D (2-D step) was used to correct HOAs...
June 1, 2017: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/28586910/corneal-potential-maps-measured-with-multi-electrode-electroretinography-in-rat-eyes-with-experimental-lesions
#20
Zahra Derafshi, Brian E Kunzer, Emily M Mugler, Nataliya Rokhmanova, Dong-Wook Park, Hadi Tajalli, Krithi Shetty, Zhenqiang Ma, Justin C Williams, John R Hetling
Purpose: Conventional full-field flash electroretinography (ERG) yields a single response waveform that can be useful in the early detection and diagnosis of many diseases affecting the retina. It is an objective measurement that probes the entire retina. However, localized areas of dysfunction have relatively small influence on ERG amplitudes compared to normal ranges. Here we evaluate the use of corneal potential maps obtained in response to full-field flash stimuli for sensitivity to local areas of retinal damage...
June 1, 2017: Investigative Ophthalmology & Visual Science
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