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https://www.readbyqxmd.com/read/29667855/a-disposable-tear-glucose-biosensor-part-5-improvements-in-reagents-and-tear-sampling-component
#1
Chi En Lin, Yuka Ito, Anna Deng, Jared Johns, Daniel Matloff, Curtiss B Cook, Koji Sode, Jeffrey T La Belle
A tear glucose (TG) sensor with an integrated tear sampler can provide a noninvasive method for calibrating the continuous TG contact lens and monitoring glucose. Expanding from previous work, an improved TG sensor that implements dried reagents, genetically modified glucose dehydrogenase (GDH), and a tear sampler was developed and compared against the TG sensor prepared with commercial GDH. It was found that neither sensor was affected by the tear interferents: ascorbic acid, acetaminophen, and uric acid. The sensor prepared with commercial GDH generated higher current...
April 1, 2018: Journal of Diabetes Science and Technology
https://www.readbyqxmd.com/read/29666023/the-influence-of-lens-care-systems-on-eyelid-tissue-changes-during-silicone-hydrogel-contact-lens-wear
#2
Michel Guillon, Cécile Maissa, Stéphanie Wong, Trisha Patel, Renée Garofalo
PURPOSE: To compare the effects of a hydrogen peroxide (H2 O2 )-based lens care solution and a polyhexamethylene biguanide (PHMB) multi-purpose solution on the eyelids when used with silicone hydrogel (SiHy) contact lenses. METHODS: A total of 74 symptomatic wearers of ACUVUE® OASYS® (senofilcon A; n = 39) or PureVision® (balafilcon A; n = 35) contact lenses were randomised 1:1 to either CLEAR CARE® Cleaning & Disinfecting Solution or renu® fresh™ multi-purpose solution (n = 37 each)...
April 14, 2018: Contact Lens & Anterior Eye: the Journal of the British Contact Lens Association
https://www.readbyqxmd.com/read/29663139/corneal-biopsy-for-diagnosis-of-recalcitrant-microbial-keratitis
#3
Dana Robaei, U-Teng Chan, Pauline Khoo, Svetlana Cherepanoff, Yi-Chiao Li, Jane Hanrahan, Stephanie Watson
PURPOSE: To document the findings of corneal biopsies for progressive microbial keratitis in a large tertiary referral institution. METHODS: A retrospective medical records review of all patients who underwent at least one corneal biopsy for the diagnosis of microbial keratitis at Sydney Eye Hospital, Australia between January 1, 2010 and December 31, 2016 was performed. RESULTS: Thirty-eight patients (18 men and 20 women) underwent a corneal biopsy for progressive microbial keratitis unresponsive to broad-spectrum topical antimicrobials...
April 16, 2018: Graefe's Archive for Clinical and Experimental Ophthalmology
https://www.readbyqxmd.com/read/29656886/oscillatory-squeeze-film-analysis-of-soft-contact-lenses
#4
Éanna Mac Donnchadha, Cristina Leal, Harry Esmonde
The complex modulus of a soft contact lens affects the optical performance, fitting, on-eye movement, wettability, physiological impact and overall comfort of the lens. However, despite acknowledgement that the mechanical behaviour of contact lenses is time-dependent, the rheological characteristics of contact lenses remain under-defined. While existing studies have focussed on elasticity to describe lens behaviour, this paper proposes using oscillatory squeeze film analysis to evaluate the complex modulus...
April 13, 2018: Contact Lens & Anterior Eye: the Journal of the British Contact Lens Association
https://www.readbyqxmd.com/read/29644148/differential-deposition-of-fluorescently-tagged-cholesterol-on-commercial-contact-lenses-using-a-novel-in-vitro-eye-model
#5
Hendrik Walther, Chau-Minh Phan, Lakshman N Subbaraman, Lyndon Jones
Purpose: We evaluate the differences in lipid uptake and penetration in daily disposable (DD) contact lenses (CL) using a conventional "in-vial" method compared to a novel in vitro eye model. Methods: The penetration of fluorescently labelled 22-(N-(7-Nitrobenz-2-Oxa-1,3-Diazol-4-yl)Amino)-23,24-Bisnor-5-Cholen-3beta-Ol (NBD)-cholesterol on three silicone hydrogel (SH) and four conventional hydrogel (CH) DD CLs were investigated. CLs were incubated for 4 and 12 hours in a vial, containing 3...
April 2018: Translational Vision Science & Technology
https://www.readbyqxmd.com/read/29643799/optical-coherence-tomography-examination-of-the-anterior-segment-in-a-case-of-corneal-perforation-and-lens-trauma-by-chestnut-burr
#6
Takashi Ono, Yosai Mori, Ryohei Nejima, Takuya Iwasaki, Shiro Amano, Kazunori Miyata
Chestnut burrs, the thorny encapsulation of chestnut fruit, can sometimes cause corneal injuries and ulceration, with poor prognoses. We report a case of corneal perforation and damaged anterior lens capsule due to a chestnut burr, using anterior segment optical coherence tomography (AS-OCT). A 67-year-old woman with a chestnut burr injury in her right eye was referred to our hospital. Her right best-corrected visual acuity (BCVA) was 0.8. Slit-lamp examination and AS-OCT showed perforation involving the endothelial layer at the center of the cornea...
January 2018: Case Reports in Ophthalmology
https://www.readbyqxmd.com/read/29643792/a-case-of-neurotrophic-keratopathy-associated-with-nasopharyngeal-carcinoma
#7
Tomoko Sato, Koji Sugioka, Aya Kodama-Takahashi, Masahiko Fukuda, Hiroshi Mishima, Yoshikazu Shimomura
Purpose: To report a case of neurotrophic keratopathy associated with nasopharyngeal carcinoma. Case Report: A 59-year-old man who had been diagnosed with a nasopharyngeal carcinoma was referred to the authors because of visual disturbance and pain in his right eye. Slit-lamp examination revealed a corneal epithelial defect and corneal stromal edema surrounding the epithelial defect area in his right eye. Magnetic resonance imaging showed a mass in his cavernous sinus, which was identified as nasopharyngeal carcinoma (NPC)...
January 2018: Case Reports in Ophthalmology
https://www.readbyqxmd.com/read/29643713/modified-conjunctival-flap-as-a-primary-procedure-for-nontraumatic-acute-corneal-perforation
#8
Yi-Chen Sun, Jason P Kam, Tueng T Shen
Objective: Appropriate management of nontraumatic acute corneal perforation is always a challenge even with the many advances in surgical materials and techniques. We reported the outcomes of a case series of acute corneal perforation repair using a newly modified conjunctival flap with amniotic membrane transplant (AMT), fibrin glue, and a bandage soft contact lens (BCL). Materials and Methods: A total of 13 consecutive referral cases with nontraumatic acute corneal perforation at the University of Washington were reviewed...
January 2018: Ci Ji Yi Xue za Zhi, Tzu-chi Medical Journal
https://www.readbyqxmd.com/read/29642830/-a-new-strategy-for-enhancing-acanthamoebicidal-activity-with-synthesis-of-nanoflower-of-laurocerausus-officinalis-roemer-cherry-laurel-fruit-extracts
#9
Ayşe Baldemir, Ülkü Karaman, Sadi Yusufbeyoğlu, Ayşe Eken, Nilay Ildız, Selen İlgün, Cemil Çolak, Gamze Kaçmaz, İsmail Öçsoy, Soner Çankaya
Pathogenic Acanthamoeba species often cause infection known as Acanthamoeba keratitis among people who use contact lenses. It is a type of infection that can result in corneal ulceration, visual loss or even blindness, if not treated. There are various therapeutic options available in the treatment of Acanthamoeba infections but they are usually tough treatments with limited efficacy. For instance, hydrogen peroxide (H2 O2 ) is a commonly used contact lens disinfectant which is effective against Acanthamoeba but it is toxic to the cornea...
January 2018: Mikrobiyoloji Bülteni
https://www.readbyqxmd.com/read/29642404/improved-optical-and-morphological-properties-of-vinyl-substituted-hybrid-silica-materials-incorporating-a-zn-metalloporphyrin
#10
Zoltán Dudás, Eugenia Fagadar-Cosma, Adél Len, Loránd Románszki, László Almásy, Beatrice Vlad-Oros, Daniela Dascălu, Andraž Krajnc, Manfred Kriechbaum, Andrei Kuncser
This work is focused on a novel class of hybrid materials exhibiting enhanced optical properties and high surface areas that combine the morphology offered by the vinyl substituted silica host, and the excellent absorption and emission properties of 5,10,15,20-tetrakis( N -methyl-4-pyridyl)porphyrin-Zn(II) tetrachloride as a water soluble guest molecule. In order to optimize the synthesis procedure and the performance of the immobilized porphyrin, silica precursor mixtures of different compositions were used...
April 6, 2018: Materials
https://www.readbyqxmd.com/read/29627356/sustained-ophthalmic-delivery-of-highly-soluble-drug-using-ph-triggered-inner-layer-embedded-contact-lens
#11
Qiang Zhu, Hongbo Cheng, Yingnan Huo, Shirui Mao
In the present work the feasibility of using inner layer-embedded contact lenses (CLs) to achieve sustained release of highly water soluble drug, betaxolol hydrochloride (BH) on the ocular surface was investigated. Blend film of cellulose acetate and Eudragit S100 was selected as the inner layer, while silicone hydrogel was used as outer layer to construct inner layer-embedded contact lenses. Influence of polymer ratio in the blend film on in vitro drug release behavior in phosphate buffered solution or simulated tear fluid was studied and drug-polymer interaction, erosion and swelling of the blend film were characterized to better understand drug-release mechanism...
April 5, 2018: International Journal of Pharmaceutics
https://www.readbyqxmd.com/read/29625485/atovaquone-impairs-growth-of-aspergillus-and-fusarium-keratitis-isolates-by-modulating-mitochondrial-function-and-zinc-homeostasis
#12
Heather L Clark, Martin S Minns, Yan Sun, Tristan de Jesus, Mahmoud G Ghannoum, Eric Pearlman
Purpose: Aspergillus and Fusarium molds cause blinding corneal infections as a consequence of ocular trauma and in association with contact lens wear. As these fungi require zinc for fungal growth, we examined the effect of atovaquone, a ubiquinone analog that disrupts zinc homeostasis, on fungal growth in vitro and in vivo. Methods: In vitro: Aspergillus and Fusarium germinating conidia were incubated overnight with atovaquone, and hyphal growth was measured by fluorimetry...
March 1, 2018: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/29625097/chloroquine-as-a-possible-disinfection-adjunct-of-disinfection-solutions-against-acanthamoeba
#13
Eun-Kyung Moon, Seungeun Lee, Fu-Shi Quan, Hyun-Hee Kong
Acanthamoeba keratitis is commonly encountered by contact lens wearers. Contact lens solution plays an important role in the safe use of contact lenses. The most popular products for disinfecting lenses are multipurpose disinfecting solutions (MPDS). However, almost all MPDS retailed in Korea are ineffective in killing Acanthamoeba. The objective of this study was to determine the possibility of using autophagy inhibitor chloroquine as a disinfecting agent to improve the amoebicidal activity of MPDS against Acanthamoeba, especially the cyst...
April 3, 2018: Experimental Parasitology
https://www.readbyqxmd.com/read/29611372/scleral-buckling-under-a-slit-lamp-illumination-system-with-a-contact-wide-angle-viewing-lens-compared-with-an-indirect-ophthalmoscope
#14
Seung Yong Choi, Youlim Lee, Mirinae Kim, Young Hoon Park
PURPOSE: To investigate the outcomes of scleral buckling surgery performed under a slit-lamp illumination system (Visulux) with a contact wide-angle viewing lens (Mini Quad) in patients with rhegmatogenous retinal detachment (RRD) and to compare these outcomes with those of surgery performed under an indirect ophthalmoscope. METHODS: By retrospective review of electronic medical records, patients with RRD who had undergone scleral buckling surgery were identified...
March 13, 2018: Korean Journal of Ophthalmology: KJO
https://www.readbyqxmd.com/read/29611370/influence-of-sodium-hyaluronate-concentration-on-corneal-aberration-in-soft-contact-lens-wearers
#15
Jong Soo Lee, Jong Moon Park, Hyun Kyung Cho, Su Jin Kim, Hyoun Do Huh, Young Min Park
PURPOSE: This study aimed to evaluate the influence of varying concentrations of sodium hyaluronate (SH) eye drops on corneal aberrations in normal individuals wearing silicone hydrogel contact lenses. METHODS: Normal individuals wearing silicone hydrogel contact lenses were enrolled in this study. Subjects were classified into two groups depending on the concentration of the preservative-free SH used (group 1, 0.1% SH; group 2, 0.3% SH). All subjects were asked to blink five times after instillation of the SH eye drop and before the Galilei measurements...
March 13, 2018: Korean Journal of Ophthalmology: KJO
https://www.readbyqxmd.com/read/29607856/hybrid-contact-lenses-for-visual-management-of-patients-after-keratoplasty
#16
Y Altay, O Balta, A Burcu, F Ornek
Aim: This study aims to report the outcomes of new-generation hybrid contact lenses for visual rehabilitation of postkeratoplasty patients. Materials and Methods: Twenty eyes of twenty postkeratoplasty patients were fitted with hybrid lenses. Each patient's keratometric values, ocular surface irregularity indices, central corneal thickness (CCT), uncorrected visual acuity (UCVA), spectacle-corrected visual acuity, contact lens-corrected visual acuity, contact lens fitting data, and contact lens daily wearing time were recorded...
April 2018: Nigerian Journal of Clinical Practice
https://www.readbyqxmd.com/read/29606846/double-sided-design-of-electrodes-driving-tunable-dielectrophoretic-miniature-lens
#17
Yousuf Almoallem, Hongrui Jiang
We demonstrate the design methodology, geometrical analysis, device fabrication, and testing of a double-sided design (DSD) of tunable-focus dielectrophoretic liquid miniature lenses. This design is intended to reduce the driving voltage for tuning the lens, utilizing a double-sided electrode design that enhances the electric field magnitude. Fabricated devices were tested and measurements on a goniometer showed changes of up to 14° in the contact angle when the dielectrophoretic force was applied under 25 Vrms ...
October 2017: Journal of Microelectromechanical Systems
https://www.readbyqxmd.com/read/29604280/effect-of-a-contact-lens-for-in-vivo-mouse-retinal-imaging-effective-focal-length-changes-and-monochromatic-aberrations
#18
Pengfei Zhang, Jacopo Mocci, Daniel J Wahl, Ratheesh Kumar Meleppat, Suman K Manna, Martino Quintavalla, Riccardo Muradore, Marinko V Sarunic, Stefano Bonora, Edward N Pugh, Robert J Zawadzki
For in vivo mouse retinal imaging, especially with Adaptive Optics instruments, application of a contact lens is desirable, as it allows maintenance of cornea hydration and helps to prevent cataract formation during lengthy imaging sessions. However, since the refractive elements of the eye (cornea and lens) serve as the objective for most in vivo retinal imaging systems, the use of a contact lens, even with 0 Dpt. refractive power, can alter the system's optical properties. In this investigation we examined the effective focal length change and the aberrations that arise from use of a contact lens...
March 28, 2018: Experimental Eye Research
https://www.readbyqxmd.com/read/29600186/symptomatic-accommodative-and-binocular-dysfunctions-from-the-use-of-flat-panel-displays
#19
Esteban Porcar, Juan Carlos Montalt, Álvaro M Pons, Enrique España-Gregori
AIM: To determine the presence of symptomatic accommodative and non-strabismic binocular dysfunctions (ANS BD) in a non-presbyopic population of video display unit (VDU) users with flat-panel displays. METHODS: One hundred and one VDU users, aged between 20 to 34y, initially participated in the study. This study excluded contact-lens wearers and subjects who had undergone refractive surgery or had any systemic or ocular disease. First, subjects were asked about the type and nature of eye symptoms they experienced during VDU use...
2018: International Journal of Ophthalmology
https://www.readbyqxmd.com/read/29597982/fluoride-removal-from-groundwater-using-chemically-modified-rice-husk-and-corn-cob-activated-carbon
#20
Berhane Desta Gebrewold, Pimluck Kijjanapanich, Eldon R Rene, P N L Lens, Ajit P Annachhatre
The fluoride adsorption potential of chemically modified rice husk and corn cob activated carbon was investigated in batch and column tests.‏ The effect of pH, contact time, initial fluoride concentration and adsorbent dose on the adsorption capacity and efficiency was studied.‏ Batch experimental results were analysed using analysis of variance (ANOVA).‏ The maximum adsorption capacity of 7.‏9 and 5.‏8 mg/g and a removal efficiency of 91 and 89% were achieved in batch tests, respectively, for rice husk and corn cob activated carbon...
March 29, 2018: Environmental Technology
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