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https://www.readbyqxmd.com/read/29908870/current-and-upcoming-therapies-for-corneal-neovascularization
#1
REVIEW
Danial Roshandel, Medi Eslani, Alireza Baradaran-Rafii, Albert Y Cheung, Khaliq Kurji, Sayena Jabbehdari, Alejandra Maiz, Setareh Jalali, Ali R Djalilian, Edward J Holland
The cornea is unique because of its complete avascularity. Corneal neovascularization (CNV) can result from a variety of etiologies including contact lens wear; corneal infections; and ocular surface diseases due to inflammation, chemical injury, and limbal stem cell deficiency. Management is focused primarily on the etiology and pathophysiology causing the CNV and involves medical and surgical options. Because inflammation is a key factor in the pathophysiology of CNV, corticosteroids and other anti-inflammatory medications remain the mainstay of treatment...
June 14, 2018: Ocular Surface
https://www.readbyqxmd.com/read/29905583/contact-lens-solutions-and-contact-lens-discomfort-examining-the-correlations-between-solution-components-keratitis-and-contact-lens-discomfort
#2
Christopher J Kuc, Kenneth A Lebow
OBJECTIVES: This article will examine the current literature, as it relates to contact lens discomfort (CLD) secondary to contact lens solutions. The reader will better understand the characteristics of contact lenses, as they uniquely interact with each type of contact lens solution and also gain a better comprehension of the components of contact lens solution such as preservatives, surfactants, and chelating agents, which may contribute to discomfort. By investigating corneal staining theory and the mechanisms that contribute to its presence, the reader will gain insight into this clinical finding, which relates to selection of contact lens solutions...
June 13, 2018: Eye & Contact Lens
https://www.readbyqxmd.com/read/29899545/soft-transparent-graphene-contact-lens-electrodes-for-conformal-full-cornea-recording-of-electroretinogram
#3
Rongkang Yin, Zheng Xu, Ming Mei, Zhaolong Chen, Kai Wang, Yanlin Liu, Tao Tang, Manish Kr Priydarshi, Xuejuan Meng, Siyuan Zhao, Bing Deng, Hailin Peng, Zhongfan Liu, Xiaojie Duan
Visual electrophysiology measurements are important for ophthalmic diagnostic testing. Electrodes with combined optical transparency and softness are highly desirable, and sometimes indispensable for many ocular electrophysiology measurements. Here we report the fabrication of soft graphene contact lens electrodes (GRACEs) with broad-spectrum optical transparency, and their application in conformal, full-cornea recording of electroretinography (ERG) from cynomolgus monkeys. The GRACEs give higher signal amplitude than conventional ERG electrodes in recordings of various full-field ERG responses...
June 13, 2018: Nature Communications
https://www.readbyqxmd.com/read/29889290/agreement-between-internal-astigmatism-and-posterior-corneal-astigmatism-in-pseudophakic-eyes
#4
Sepehr Feizi, Siamak Delfazayebaher, Mohammad Ali Javadi
PURPOSE: To directly measure internal astigmatism and evaluate its agreement with posterior corneal astigmatism in pseudophakic eyes. METHODS: This prospective study enrolled 32 eyes of 32 patients (18 women, 56.3%) who underwent phacoemulsification with implantation of a non-toric monofocal intraocular lens (IOL). Two months postoperatively, posterior corneal astigmatism was measured using a Pentacam Scheimpflug analyzer (Oculus Optikgeräte GmbH, Wetzlar, Germany)...
June 1, 2018: Journal of Refractive Surgery
https://www.readbyqxmd.com/read/29887751/static-bistability-of-spherical-caps
#5
Matteo Taffetani, Xin Jiang, Douglas P Holmes, Dominic Vella
Depending on its geometry, a spherical shell may exist in one of two stable states without the application of any external force: there are two 'self-equilibrated' states, one natural and the other inside out (or 'everted'). Though this is familiar from everyday life-an umbrella is remarkably stable, yet a contact lens can be easily turned inside out-the precise shell geometries for which bistability is possible are not known. Here, we use experiments and finite-element simulations to determine the threshold between bistability and monostability for shells of different solid angle...
May 2018: Proceedings. Mathematical, Physical, and Engineering Sciences
https://www.readbyqxmd.com/read/29885816/a-report-of-10-patients-with-acanthamoeba-keratitis
#6
E A Alfonso-Muñoz, M J Roig-Revert, E Fernández-López, M Hernández-Díaz, R Araujo-Miranda, C Peris-Martínez
CLINICAL CASES: Cases are presented of 10 patients with Acanthamoeba keratitis treated between 2008 and 2017. All were contact lens wearers. All of them received treatment with a biguanide combined with a diamidine. In 3 cases the infestation did not exceed the superficial stroma, responding to topical treatment. In 7, the infection reached the deep stroma, with 6 of these cases requiring penetrating keratoplasty (PKP), 3 of them therapeutic PKP because of perforation risk or ocular spreading...
June 6, 2018: Archivos de la Sociedad Española de Oftalmología
https://www.readbyqxmd.com/read/29885342/a-comparison-of-in-vitro-cytotoxicity-assays-in-medical-device-regulatory-studies
#7
REVIEW
Xuemei Liu, Denise P Rodeheaver, Jeffrey C White, Ann M Wright, Lisa M Walker, Fan Zhang, Stephen Shannon
Medical device biocompatibility testing is used to evaluate the risk of adverse effects on tissues from exposure to leachates/extracts. A battery of tests is typically recommended in accordance with regulatory standards to determine if the device is biocompatible. In vitro cytotoxicity, a key element of the standards, is a required endpoint for all types of medical devices. Each validated cytotoxicity method has different methodology and acceptance criteria that could influence the selection of a specific test...
June 6, 2018: Regulatory Toxicology and Pharmacology: RTP
https://www.readbyqxmd.com/read/29875854/the-correlation-between-daily-lens-wear-duration-and-dry-eye-syndrome
#8
Rodiah Rahmawaty Lubis, Monica Tumiar Hanna Gultom
AIM: To analyze the correlation between the daily lens wear duration and dry eye syndrome. SUBJECTS AND METHODS: This study was an analytic cross sectional study using consecutive sampling conducted among the students in Economy and Bussiness Faculty and Faculty of Humanities in University of Sumatera Utara aged between 17 to 23 that wore contact lens continously for at least a year and 5 days a week. The symptoms were assessed using Contact Lens Dry Eye Questionnaire-8 (CLDEQ-8) and interview about their contact lens comfort; eye drops usage, contact lens washing habit, daily circumstances, places to buy contact lens and personal experince in wearing contact lens...
May 20, 2018: Open Access Macedonian Journal of Medical Sciences
https://www.readbyqxmd.com/read/29862064/characterization-of-soft-contact-lens-edge-fitting-during-daily-wear-using-ultrahigh-resolution-optical-coherence-tomography
#9
Lele Cui, Sisi Chen, Weihe Zhou, Kaixuan Sheng, Lei Zhang, Meixiao Shen, Ming Li
Purpose: To determine conjunctival overlap over the edge of soft contact lens and to visualize the peripheral postlens tear film (PoLTF) underneath soft contact lenses using ultrahigh-resolution optical coherence tomography (UHR-OCT). Methods: Twenty participants (4 males and 16 females, 23.0 ± 3.7 years) were fitted with two different types of soft contact lenses randomly. The limbus with lens was imaged with the UHR-OCT at the horizontal meridian every two hours up to 6 hours during lens wear...
2018: Journal of Ophthalmology
https://www.readbyqxmd.com/read/29860459/bacterial-coaggregation-and-cohesion-among-isolates-from-contact-lens-cases
#10
Ananya Datta, Fiona Stapleton, Mark D P Willcox
Purpose: The aim of this study was to examine cohesion, coaggregation, and coculture between bacteria commonly isolated from contact lens cases. Methods: Staphylococcus epidermidis, Staphylococcus haemolyticus, Micrococcus luteus, and Acinetobacter radioresistens (two strains each) isolated from contact lens cases of two asymptomatic wearers were used in this study. In the cohesion assay, bacteria were grown, washed, and examined by incubating lens cases with two different types of bacteria sequentially and assessing the number of adhered cells of each isolate...
June 1, 2018: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/29858820/controlled-delivery-of-pirfenidone-through-vitamin-e-loaded-contact-lens-ameliorates-corneal-inflammation
#11
Phillip Dixon, Tanushri Ghosh, Kalyani Mondal, Aditya Konar, Anuj Chauhan, Sarbani Hazra
Chemical injury by alkali burn is a major cause of corneal blindness in the clinical setting. Current management advocates multiple therapies aimed to prevent inflammation, initiate quick re-epithelialization, arrest the fibrosis, and avoid dry eye and pain by using bandage contact lenses. We hypothesized sustained delivery of the anti-inflammatory, antifibrotic drug pirfenidone through vitamin E-loaded contact lenses as a logical single approach to counter the pathology involved. Vitamin E particles were created in situ in commercial silicon hydrogel contact lenses by soaking the lenses in a vitamin E-ethanol solution...
June 1, 2018: Drug Delivery and Translational Research
https://www.readbyqxmd.com/read/29851781/acute-exacerbation-of-staphylococcal-catarrhal-infiltration-associated-with-treatment-for-pseudomonas-aeruginosa-keratitis-a-case-report
#12
Seung Pil Bang, Jong Hwa Jun
RATIONALE: Simultaneous presentation of peripheral infiltrates, which can be easily misidentified as satellite lesions, is rarely observed in patients with acute infectious keratitis. PATIENT CONCERNS: A 70-year-old woman was referred to our clinic due to acute mucopurulent keratitis following application of a therapeutic soft contact lens for the treatment of epithelial defects caused by entrance of soil foreign bodies into the eye. The patient was diagnosed with Pseudomonas keratitis, following which she was treated with alternating administration of fourth-generation fluoroquinolone (Vigamox) and 5% fortified ceftazidime eyedrops every 2 hours...
June 2018: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29849773/extended-low-oxygen-transmissibility-contact-lens-use-induces-alterations-in-the-concentration-of-proinflammatory-cytokines-enzymes-and-electrolytes-in-tear-fluid
#13
Luis Fernando Barba Gallardo, Martín Humberto Muñoz Ortega, Javier Ventura Juarez, Liseth Rubí Aldaba Muruato, Esperanza Sánchez Alemán, Eduardo Emmanuel Valdez Morales, Sugela Susana Blancas Zugarazo, Jose Rafael Villafan Bernal
Prolonged and continuous use of contact lenses for as long as 3 or 4 weeks is common in Mexico due to the low socioeconomic status, poor patient education and self-neglect. Furthermore, wearing contact lenses with low oxygen permeability is common due to their low cost. Thus, patients seek ophthalmologic evaluation due to signs and symptoms of overuse such as red eye, discomfort and tearing. In the present study, the effect of wearing soft contact lenses with a low oxygen permeability on the tear fluid composition after 1 day, 1 week and 1 month without removing them was examined...
May 2018: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/29847665/mixed-model-analysis-of-between-subject-variability-in-overnight-corneal-swelling-and-deswelling-with-silicone-hydrogel-lenses
#14
Amir M Moezzi, Natalie Hutchings, Desmond Fonn, Trefford L Simpson
Purpose: To model between subject variability of corneal swelling (CS) and deswelling after overnight wear of silicone hydrogel (SiHy) contact lenses. Methods: A total of 29 neophyte subjects wore 12 SiHy lenses with central transmissibility range of 31 to 211 Dk/t units on separate nights, in random order, and on one eye only. The contralateral eye served as the control. Central corneal thickness was measured using digital optical pachymetry before lens insertion, immediately after lens removal on waking, then 20, 40 minutes, 1, 2, and 3 hours later...
May 1, 2018: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/29804935/corneal-oedema-in-a-unilateral-corneal-graft-patient-induced-by-high-dk-mini-scleral-contact-lens
#15
Natalie C Guillon, Andrew Godfrey, David S Hammond
INTRODUCTION: Scleral contact lenses are increasingly becoming accepted as the method of choice for visual correction of the irregular cornea. As such, cases have surfaced which demonstrate complications arising from mini-scleral lenses. Identification of these issues and adjusting fitting techniques accordingly is necessary for reducing the risks associated with mini-scleral lens wear. CASE REPORT: A 58 year old Caucasian female was referred for rigid gas permeable contact lens fitting for correction of right irregular astigmatism post penetrating keratoplasty...
May 24, 2018: Contact Lens & Anterior Eye: the Journal of the British Contact Lens Association
https://www.readbyqxmd.com/read/29800726/cellular-fluorescein-hyperfluorescence-is-dynamin-dependent-and-increased-by-tetronic-1107-treatment
#16
Tahmina F Khan, Bianca L Price, Philip B Morgan, Carole Maldonado-Codina, Curtis B Dobson
Sodium fluorescein ('fluorescein') staining of the ocular surface is frequently an indicator of compromised ocular health, and increases in the presence of certain contact lens multi-purpose solutions (MPS), a phenomenon known as solution induced corneal staining (SICS). The mechanism(s) underpinning fluorescein hyperfluorescence are uncertain, though may reflect increased cellular uptake of fluorescein by corneal epithelial cells. We have developed an in vitro model to study fluorescein uptake in both 'generic' mammalian cells (murine fibroblasts) and human corneal cells...
May 22, 2018: International Journal of Biochemistry & Cell Biology
https://www.readbyqxmd.com/read/29800578/simple-limbal-epithelial-transplantation-slet-a-review-on-current-approach-and-future-directions
#17
Davide Borroni, Bogumil Wowra, Vito Romano, Maria Boyadzhieva, Diego Ponzin, Stefano Ferrari, Sajjad Ahmad, Mohit Parekh
Simple limbal epithelial transplant (SLET) is a recently developed technique for treating limbal stem cell deficiency (LSCD) caused by ocular burns. A small limbal biopsy from the donor eye, usually from the patient's healthy eye, is excised and dissected into multiple pieces. An amniotic membrane is patched using fibrin glue on the diseased eye after removing the conjunctivalized pannus from the corneal surface. The limbal biopsy pieces are placed onto the amniotic membrane, fixed with fibrin glue followed by bandaging of the ocular surface with a contact lens...
May 22, 2018: Survey of Ophthalmology
https://www.readbyqxmd.com/read/29800011/association-between-24-hour-intraocular-pressure-monitored-with-contact-lens-sensor-and-visual-field-progression-in-older-adults-with-glaucoma
#18
Carlos Gustavo De Moraes, Kaweh Mansouri, Jeffrey M Liebmann, Robert Ritch
Importance: Twenty-four-hour intraocular pressure (IOP) patterns may provide more information regarding rates of visual field progression than office-hour measurements. However, little is known about the added value of 24-hour monitoring when stratifying glaucoma risk based on rates of progression. Objective: To test the hypothesis that 24-hour IOP-related patterns recorded with a contact lens sensor (CLS) correlate with prior rates of visual field progression. Design, Setting, and Participants: A multicenter, retrospective cohort study was conducted at 50 ophthalmology care centers in 13 countries...
May 24, 2018: JAMA Ophthalmology
https://www.readbyqxmd.com/read/29797453/management-of-digital-eye-strain
#19
REVIEW
Chantal Coles-Brennan, Anna Sulley, Graeme Young
Digital eye strain, an emerging public health issue, is a condition characterised by visual disturbance and/or ocular discomfort related to the use of digital devices and resulting from a range of stresses on the ocular environment. This review aims to provide an overview of the extensive literature on digital eye strain research with particular reference to the clinical management of symptoms. As many as 90 per cent of digital device users experience symptoms of digital eye strain. Many studies suggest that the following factors are associated with digital eye strain: uncorrected refractive error (including presbyopia), accommodative and vergence anomalies, altered blinking pattern (reduced rate and incomplete blinking), excessive exposure to intense light, closer working distance, and smaller font size...
May 23, 2018: Clinical & Experimental Optometry: Journal of the Australian Optometrical Association
https://www.readbyqxmd.com/read/29787490/clinical-performance-of-a-new-bitangential-mini-scleral-lens
#20
Henny M Otten, Bart J J J van der Linden, Esther-Simone Visser
SIGNIFICANCE: New bitangential mini-scleral lens designs provide a highly precise fit, follow the scleral shape, are comfortable to wear, and can correct residual astigmatism. This new scleral lens design complements the arsenal of medical contact lenses available to eye care practitioners. PURPOSE: The aim of this study was to evaluate the subjective and objective performance of a new mini-scleral lens design with a bitangential periphery. METHODS: In this observational study, data were collected for up to 15 months (median, 84 days; interquartile range, 76 days) from the left eyes of 133 patients fitted with this newly designed lens...
May 21, 2018: Optometry and Vision Science: Official Publication of the American Academy of Optometry
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