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https://www.readbyqxmd.com/read/29244868/cyclodextrin-containing-hydrogels-as-an-intraocular-lens-for-sustained-drug-release
#1
Xiao Li, Yang Zhao, Kaijie Wang, Lei Wang, Xiaohui Yang, Siquan Zhu
To improve the efficacy of anti-inflammatory factors in patients who undergo cataract surgery, poly(2-hydroxyethyl methacrylate-co-methyl methacrylate) (p(HEMA-co-MMA)) hydrogels containing β-cyclodextrin (β-CD) (pHEMA/MMA/β-CD) were designed and prepared as intraocular lens (IOLs) biomaterials that could be loaded with and achieve the sustained release of dexamethasone. A series of pHEMA/MMA/β-CD copolymers containing different ratios of β-CD (range, 2.77 to 10.24 wt.%) were obtained using thermal polymerization...
2017: PloS One
https://www.readbyqxmd.com/read/29241942/an-imaging-based-analysis-of-lipid-deposits-on-contact-lens-surfaces
#2
Shyam Panthi, Jason J Nichols
PURPOSE: To evaluate whether LipidTOX could stain lipid deposits on contact lens (CL) surfaces and compare lipid deposition patterns on various CL surfaces using an imaging method. METHODS: Ten CLs each of six silicone hydrogel materials and one hydrogel material were incubated in cholesteryl oleate solution (5.60mg/ml) for 12hours. The CLs were then separately stained with Oil Red O and LipidTOX and imaged under a fluorescence microscope. Twenty worn senofilcon A CLs from both eyes of ten participants were also stained similarly...
December 11, 2017: Contact Lens & Anterior Eye: the Journal of the British Contact Lens Association
https://www.readbyqxmd.com/read/29235184/rethinking-contact-lens-discomfort
#3
EDITORIAL
Nathan Efron
No abstract text is available yet for this article.
January 2018: Clinical & Experimental Optometry: Journal of the Australian Optometrical Association
https://www.readbyqxmd.com/read/29234586/aspergillus-tamarii-keratitis-in-a-contact-lens-wearer
#4
Juan Cuadros, Juan Gros-Otero, Patricia Gallego-Angui, Ann Karolin Scheu, Ángeles Montes-Mollón, Cinta Pérez-Rico, Javier Paz Moreno, Peña Gómez-Herruz, Juan Soliveri, Miguel Teus
Keratitis produced by Aspergillus tamarii has been previously described associated to an ocular injury. We report a case in a contact lens wearer with a history of previous bilateral myopic LASIK ablation, bilateral intracorneal rings and vitrectomy and scleral buckling in his left eye. The fungus could be quickly identified combining phenotype, microscopy and mass spectrometry. Treatment with intravenous amphotericin, oral voriconazole, and topical amphotericin and natamycin and voriconazole was needed for corneal preservation...
March 2018: Medical Mycology Case Reports
https://www.readbyqxmd.com/read/29233457/antimicrobial-efficacy-of-a-novel-povidone-iodine-contact-lens-disinfection-system
#5
Katsuhide Yamasaki, Fumio Saito, Ritsue Ota, Simon Kilvington
PURPOSE: Contact lens (CL) wear is a risk factor for the acquisition of microbial keratitis. Accordingly, compliance to manufacturers' recommended hygiene and disinfection procedures are vital to safe (CL) use. In this study we evaluated a novel povidone-iodine (PI) (CL) disinfection system (cleadew, Ophtecs Corporation, Japan) against a range of bacterial, fungal and Acanthamoeba. METHODS: Antimicrobial assays were conducted according to ISO 14729 using the recommended strains of bacteria and fungi, with and without the presence of organic soil...
December 7, 2017: Contact Lens & Anterior Eye: the Journal of the British Contact Lens Association
https://www.readbyqxmd.com/read/29233456/corneal-conjunctival-effects-and-blood-flow-changes-related-to-silicone-hydrogel-lens-wear-and-their-correlations-with-end-of-day-comfort
#6
Luigina Sorbara, Jyotsna Maram, Trefford Simpson, Natalie Hutchings
PURPOSE: First, to examine how wearing high and low modulus lenses with two different base curves affected lens fit, and the corneal tissue and bulbar conjunctival vascular tissue (bulbar redness and blood velocity). Secondly, to quantify the associations between these baseline and outcome variables and the third purpose was to correlate these variables with end of day comfort. METHODS: Thirty participants wore higher (PureVision (PV) 8.3, 8.6) and lower (Acuvue Advance (AA) 8...
December 7, 2017: Contact Lens & Anterior Eye: the Journal of the British Contact Lens Association
https://www.readbyqxmd.com/read/29221710/acanthamoeba-keratitis-in-patients-wearing-scleral-contact-lenses
#7
Matheus Porto Sticca, Linda C Carrijo-Carvalho, Isa M B Silva, Luiz A Vieira, Luciene B Souza, Rubens Belfort Junior, Fábio Ramos S Carvalho, Denise Freitas
PURPOSE: To report a series of cases of Acanthamoeba keratitis (AK) in scleral lens wearers with keratoconus to determine whether this type of contact lens presents a greater risk for development of infection. METHODS: This study reports three patients who wore scleral contact lenses to correct keratoconus and developed AK. The diagnoses of AK were established based on cultures of the cornea, scleral contact lenses, and contact lens paraphernalia. This study investigated the risk factors for infections...
December 5, 2017: Contact Lens & Anterior Eye: the Journal of the British Contact Lens Association
https://www.readbyqxmd.com/read/29221709/the-use-of-contact-lenses-among-university-students-in-chengdu-knowledge-and-practice-of-contact-lens-wearers
#8
Qiurong Zhu, Bi Yang, Nan Deng, Yifan Li, Tingwei Wang, Huang Qi, Longqian Liu
PURPOSE: To assess the prevalence and general knowledge of contact lens wearers among college students in Chengdu, a metroplolitan of Chinaand find out the routine habits of use and hygienic conditions when wearing contact lenses. METHOD: The questionnaire was distributed to 1,600 ametropic participants who were from 8 different universities. Data about demographics, general contact lens handling habits, personal attitudes, hygiene behaviors and eye health conditions were collected...
December 5, 2017: Contact Lens & Anterior Eye: the Journal of the British Contact Lens Association
https://www.readbyqxmd.com/read/29221708/daily-versus-monthly-disposable-contact-lens-which-is-better-for-ocular-surface-physiology-and-comfort
#9
Kishor Sapkota, Sandra Franco, Madalena Lira
PURPOSE: To investigate the effect of soft contact lenses (SCL) wearing modality and lens materials on the changes in conjunctival bulbar and limbal redness and conjunctival and corneal staining after two months of SCL wear. Comfort level was also analyzed. METHODS: In this longitudinal clinical trial, forty-seven neophyte myopic subjects were fitted with a monthly disposable lens (lotrafilcon-B or comfilcon-A or balafilcon-A) in one eye and a daily disposable lens (nelfilcon-A or stenofilcon-A or nesofilcon-A) in the other eye, randomly selected...
December 5, 2017: Contact Lens & Anterior Eye: the Journal of the British Contact Lens Association
https://www.readbyqxmd.com/read/29219900/diagnostic-challenges-in-nocardia-keratitis
#10
Joséphine Behaegel, Sorcha Ní Dhubhghaill, Carina Koppen
OBJECTIVE: To present a case of diagnostic confusion in Nocardia keratitis in a contact lens wearer and to illustrate the characteristic clinical findings of this rare entity. METHODS: Case report of Nocardia keratitis that was mistaken for acanthamoeba, herpetic, and fungal keratitis in three tertiary corneal referral centers before the correct diagnosis of Nocardia infection was made. RESULTS: A 29-year-old contact lens wearer was referred to our hospital for a contact lens-associated bacterial keratitis, not improving under standard bacterial treatment...
December 5, 2017: Eye & Contact Lens
https://www.readbyqxmd.com/read/29219898/orthokeratology-and-contact-lens-quality-of-life-questionnaire-ocl-qol
#11
Colm McAlinden, Michael Lipson
OBJECTIVES: To develop a quality of life (QoL) instrument for patients fitted with Orthokeratology (OrthoK) and other modalities of contact lenses. METHODS: A 45-item pilot questionnaire was developed from an extensive literature review, focus groups, and interviews. Subsequently, 234 participants fitted with contact lenses (OrthoK, soft lenses, and gas permeable lenses) or spectacles completed the pilot questionnaire. Rasch analysis was used to assess the psychometric properties in terms of person separation, item fit statistics, category threshold ordering, differential item functioning (DIF), and targeting...
December 5, 2017: Eye & Contact Lens
https://www.readbyqxmd.com/read/29217475/in-vitro-drug-release-and-in-vivo-safety-of-vitamin-e-and-cysteamine-loaded-contact-lenses
#12
Phillip Dixon, Richard C Fentzke, Arnab Bhattacharya, Aditya Konar, Sarbani Hazra, Anuj Chauhan
Cystinosis is an orphan disease caused by a genetic mutation that leads to deposition of cystine crystals in many organs including cornea. Ophthalmic manifestation of the disease can be treated with hourly instillation of cysteamine eye drops. The hourly eye drop instillation is tedious to the patients leading to poor compliance and additionally, significant degradation of the drug occurs within one week of opening the bottle, which further complicates this delivery approach. This paper focuses on designing a contact lens to treat the disease with improved efficacy compared to eye drops, and also exploring safety of the drug eluding contact lens in an animal model...
December 4, 2017: International Journal of Pharmaceutics
https://www.readbyqxmd.com/read/29217455/a-new-method-to-analyse-the-effect-of-multifocal-contact-lenses-on-visual-function
#13
I Sanchez, S Ortiz-Toquero, M Blanco, R Martin
PURPOSE: Presbyopic contact lens (CL) fittings produce simultaneous vision, providing different retinal images that reduce visual quality and wearers' satisfaction. The purpose of this study was to develop a new method to isolate the multifocality effect of different CL options to manage presbyopia, analysing the impact on binocular visual acuity (VA), stereopsis and contrast sensitivity (CS) and determining the effect of the use of a yellow filter (YF) on visual function. METHODS: A prospective and double-masked randomized pilot study involving 20 healthy volunteers was conducted...
December 4, 2017: Contact Lens & Anterior Eye: the Journal of the British Contact Lens Association
https://www.readbyqxmd.com/read/29217454/patient-related-barriers-to-rigid-gas-permeable-rgp-lens-wear-among-keratoconus-patients-in-jordan
#14
May M Bakkar, Mera F Haddad, Mohammad Al Qadire
PURPOSE: To assess potential patient-related barriers to rigid gas permeable (RGP) lens wear for vision rehabilitation in a sample of keratoconus (KC) patients in Jordan. METHODS: Barriers for RGP contact lens wear among KC patients were discussed and specified by a focus group which consisted of five optometrists who are involved in contact lens practice. The focus group addressed potential barriers for RGP lens wear from the patient's perspective. The identified barriers were then used to design the final questionnaire used in the study...
December 4, 2017: Contact Lens & Anterior Eye: the Journal of the British Contact Lens Association
https://www.readbyqxmd.com/read/29217022/focal-limbal-stem-cell-deficiency-associated-with-soft-contact-lens-wear
#15
Karolien Termote, Steven Schendel, Gregory Moloney, Simon P Holland, Alex P Lange
OBJECTIVE: The aim of this study is to summarize the clinical characteristics of patients with contact lens-associated focal limbal stem cell deficiency (FLSCD) from a tertiary corneal referral centre. DESIGN: Retrospective, observational case series in a tertiary care centre. METHODS: Patients with contact lens-associated FLCSD were identified in our database. Clinical data were retrieved by chart review. A questionnaire asking for contact lens brand, type, cleaning solution, and duration of contact lens wear was sent to the patients with telephone follow-up...
December 2017: Canadian Journal of Ophthalmology. Journal Canadien D'ophtalmologie
https://www.readbyqxmd.com/read/29213204/in-vitro-release-of-two-anti-muscarinic-drugs-from-soft-contact-lenses
#16
Alex Hui, Magdalena Bajgrowicz-Cieslak, Chau-Minh Phan, Lyndon Jones
The purpose of this study was to investigate the release of the anti-myopia drugs atropine sulfate and pirenzepine dihydrochloride from commercially available soft contact lenses. Standard ultraviolet (UV) absorbance-concentration curves were generated for atropine and pirenzepine. Ten commercially available contact lenses, including four multifocal lenses, were loaded by soaking in atropine or pirenzepine solutions at two different concentrations (10 mg/mL and 1 mg/mL). The release of the drugs into phosphate-buffered saline was determined over the course of 24 hours at 34°C using UV absorbance...
2017: Clinical Ophthalmology
https://www.readbyqxmd.com/read/29212053/contaminant-back-diffusion-from-low-permeability-layers-as-affected-by-groundwater-velocity-a-laboratory-investigation-by-box-model-and-image-analysis
#17
Fabio Tatti, Marco Petrangeli Papini, Giuseppe Sappa, Massimo Raboni, Firoozeh Arjmand, Paolo Viotti
Low-permeability lenses represent potential sources of long-term release when filled from contaminant solute through direct contact with dissolved plumes. The redistribution of contaminant from low to high permeability aquifer zones (Back-Diffusion) was studied. Redistribution causes a long plume tail, commonly regarded as one of the main obstacles to effective groundwater remediation. Laboratory tests were performed to reproduce the redistribution process and to investigate the effect of pumping water on the remediation time of these contaminated low-permeability lenses...
December 3, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/29210829/in-vitro-evaluation-of-adhesion-of-two-acanthamoeba-strains-to-cosmetic-contact-lenses
#18
Berna B Bakay, Zubeyde A Polat
PURPOSE: To evaluate the factors affecting the adhesion of Acanthamoeba trophozoites to the surface of cosmetic contact lenses (CCLs). METHODS: Acanthamoeba castellanii and A. hatchetti trophozoites were inoculated onto CCLs (hema copolymer [HM] [38.5% H2O], phemfilcon [PF] [55% H2O], polymacon [PM] [38% H2O], polyhema [PH] [%42 H2O], and hema [HM55] [55% H2O]), and the number of trophozoites adhered to the lens surfaces was assessed over time, that is, at 15 min, 1, and 24 hr...
November 28, 2017: Eye & Contact Lens
https://www.readbyqxmd.com/read/29210828/predicting-short-term-subjective-vision-performance-of-contact-lenses-used-in-myopia-control
#19
Jennie Diec, Daniel Tilia, Varghese Thomas, Ravi C Bakaraju
OBJECTIVE: To investigate whether initial assessment of contact lenses prescribed for myopia control (MC) predicts short-term visual performance. METHOD: Retrospective analysis of 43 participants in a double-masked, randomized, cross-over trial wearing at least one lens: single-vision (SV) lens (1-DAY ACUVUE MOIST) or MC lenses (MiSight or Proclear Multifocal-Distance +2.00D). Participants completed questionnaires at the fitting visit, a take-home questionnaire (THQ) 3 days after fitting and finally at the assessment visit (≥5 days after fitting)...
November 28, 2017: Eye & Contact Lens
https://www.readbyqxmd.com/read/29209437/retinal-venous-pressure-measurements-in-patients-with-flammer-syndrome-and-metabolic-syndrome
#20
Dominique Mustur, Zakieh Vahedian, Jerome Bovet, Maneli Mozaffarieh
Background: The purpose of this research is to analyze retinal venous pressure (RVP) of both eyes of patients who visited a Swiss ophthalmic practice and compare values among the following groups of patients with primary open-angle glaucoma (POAG), Flammer syndrome (FS), and metabolic syndrome (MetS). Methods: RVP was measured in both eyes of all patients who visited a Swiss ophthalmic practice during March 2016 till November 2016, and the results were analyzed retrospectively...
December 2017: EPMA Journal
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