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https://www.readbyqxmd.com/read/29214162/current-tissue-molecular-markers-in-colorectal-cancer-a-literature-review
#1
REVIEW
Gaia Peluso, Paola Incollingo, Armando Calogero, Vincenzo Tammaro, Niccolò Rupealta, Gaetano Chiacchio, Maria Laura Sandoval Sotelo, Gianluca Minieri, Antonio Pisani, Eleonora Riccio, Massimo Sabbatini, Umberto Marcello Bracale, Concetta Anna Dodaro, Nicola Carlomagno
Background: Colorectal cancer (CRC) is one of the most spread neoplasia types all around the world, especially in western areas. It evolves from precancerous lesions and adenomatous polyps, through successive genetic and epigenetic mutations. Numerous risk factors intervene in its development and they are either environmental or genetic. Aim of the Review: Alongside common screening techniques, such as fecal screening tests, endoscopic evaluation, and CT-colonography, we have identified the most important and useful biomarkers and we have analyzed their role in the diagnosis, prevention, and prognosis of CRC...
2017: BioMed Research International
https://www.readbyqxmd.com/read/29191684/model-based-iterative-reconstruction-in-low-radiation-dose-computed-tomography-colonography-preoperative-assessment-in-patients-with-colorectal-cancer
#2
Narumi Taguchi, Seitaro Oda, Masanori Imuta, Sadahiro Yamamura, Takeshi Nakaura, Daisuke Utsunomiya, Masafumi Kidoh, Yasunori Nagayama, Hideaki Yuki, Kenichiro Hirata, Yuji Iyama, Yoshinori Funama, Hideo Baba, Yasuyuki Yamashita
RATIONALE AND OBJECTIVES: To assess the effect of model-based iterative reconstruction (MBIR) on image quality and diagnostic performance of low-radiation-dose computed tomography colonography (CTC) in the preoperative assessment of colorectal cancer. MATERIALS AND METHODS: This study included 30 patients with colorectal cancer referred for surgical treatment. All patients underwent CTC with a standard dose (SD) protocol in the supine position and a low-dose (LD; radiation dose reduction of approximately 85%) protocol in the prone position...
November 27, 2017: Academic Radiology
https://www.readbyqxmd.com/read/29174927/computed-tomography-colonography-vs-colonoscopy-for-colorectal-cancer-surveillance-after-surgery
#3
David S Weinberg, Perry J Pickhardt, David H Bruining, Kristin Edwards, J G Fletcher, Marc J Gollub, Eileen M Keenan, Sonia S Kupfer, Tianyu Li, Sam J Lubner, Arnold J Markowitz, Eric A Ross
BACKGROUND & AIMS: Recommendations for surveillance after curative surgery for colorectal cancer (CRC) include a 1 year post-resection abdominal-pelvic computed tomography scan and optical colonoscopy (OC). CT colonography (CTC), when used in CRC screening, effectively identifies colorectal polyps ≥10 mm and cancers. We performed a prospective study to determine whether CTC, concurrent with CT, could substitute for OC in CRC surveillance. METHODS: Our study enrolled 231 patients with resected stage 0-III CRC, identified at 5 tertiary care academic centers...
November 22, 2017: Gastroenterology
https://www.readbyqxmd.com/read/29169607/tc-rectal-pathology-findings-at-ct-colonography
#4
M J Martínez-Sapiña Llanas, S A Otero Muinelo, C Crespo García
OBJECTIVE: To review the spectrum of benign and malignant rectal diseases, their findings on CT colonography, and their management. CONCLUSION: Although CT colonography is not the first choice for the study of rectal disease, it is indicated in cases where optical colonoscopy is contraindicated or cannot be completed. Rectal lesions can go undetected because this anatomic area is difficult to evaluate; for this reason, it is essential to ensure optimal preparation and distension, moderate balloon insufflation, and careful 2D and 3D navigation with knowledge of the spectrum of rectal disease and its CT colonography signs...
November 20, 2017: Radiología
https://www.readbyqxmd.com/read/29161144/comment-on-extracolonic-findings-at-screening-ct-colonography-prevalence-benefits-challenges-and-opportunities
#5
Antonio Poerio, Francesco Monteduro, Maurizio Zompatori
No abstract text is available yet for this article.
December 2017: AJR. American Journal of Roentgenology
https://www.readbyqxmd.com/read/29159167/accuracy-of-preoperative-local-staging-of-primary-colorectal-cancer-by-using-computed-tomography-reappraisal-based-on-data-collected-at-a-highly-organized-cancer-center
#6
Jung Sub So, Chinock Cheong, Seung Yeop Oh, Jei Hee Lee, Young Bae Kim, Kwang Wook Suh
Purpose: In patients with colorectal cancer, preoperative staging using various imaging technologies is important for establishing the treatment plan and predicting the prognosis. Although computed tomography (CT) has been used most widely, the versatility of CT accuracy was primarily because of the lack of specialization. In this study, we aimed to identify whether any advancement in abdominal CT accuracy in the prediction of local staging has occurred. Methods: Between December 2014 and November 2015, patients with colorectal cancer were retrospectively enrolled...
October 2017: Annals of Coloproctology
https://www.readbyqxmd.com/read/29153075/is-whole-colon-investigation-by-colonoscopy-computerised-tomography-colonography-or-barium-enema-necessary-for-all-patients-with-colorectal-cancer-symptoms-and-for-which-patients-would-flexible-sigmoidoscopy-suffice-a-retrospective-cohort-study
#7
Wendy Atkin, Kate Wooldrage, Urvi Shah, Kate Skinner, Jeremy P Brown, Willie Hamilton, Ines Kralj-Hans, Michael R Thompson, Karen G Flashman, Steve Halligan, Siwan Thomas-Gibson, Margaret Vance, Amanda J Cross
BACKGROUND: For patients referred to hospital with suspected colorectal cancer (CRC), it is current standard clinical practice to conduct an examination of the whole colon and rectum. However, studies have shown that an examination of the distal colorectum using flexible sigmoidoscopy (FS) can be a safe and clinically effective investigation for some patients. These findings require validation in a multicentre study. OBJECTIVES: To investigate the links between patient symptoms at presentation and CRC risk by subsite, and to provide evidence of whether or not FS is an effective alternative to whole-colon investigation (WCI) in patients whose symptoms do not suggest proximal or obstructive disease...
November 2017: Health Technology Assessment: HTA
https://www.readbyqxmd.com/read/29148927/flat-serrated-polyps-at-ct-colonography-relevance-appearance-and-optimizing-interpretation
#8
David H Kim, Meghan G Lubner, Ashley R Cahoon, B Dustin Pooler, Perry J Pickhardt
Serrated polyps are a recently recognized family of colonic polyps with subgroups that harbor future malignant potential. In the past, the significance of these lesions to the colorectal cancer carcinogenesis pathway was not recognized nor well understood. It is now known that serrated polyps account for approximately one-fourth of all sporadic colorectal cancers. The sessile serrated polyp (SSP) (also known as a sessile serrated adenoma [SSA]) is the main lesion of interest given its prevalence and subtle presentation...
November 17, 2017: Radiographics: a Review Publication of the Radiological Society of North America, Inc
https://www.readbyqxmd.com/read/29147655/magnetic-resonance-colonography-may-predict-the-need-for-bowel-resection-in-colorectal-endometriosis
#9
Arnaldo Scardapane, Filomenamila Lorusso, Mariantonietta Francavilla, Stefano Bettocchi, Fabiana Divina Fascilla, Giuseppe Angelelli, Marco Scioscia
Purpose: To define if MRI findings in patients with deep pelvic endometriosis (DPE) may be predictive for the need of bowel resection. Material and Methods: A retrospective survey of 196 pelvic MRIs of women who received laparoscopic procedures for DPE was carried out. A pelvic MRI was performed in all patients: it consisted in T2w-TSE sequences in axial, sagittal, and coronal planes and T1w and THRIVE sequences in the axial plane; the exam was completed by MR-Colonography...
2017: BioMed Research International
https://www.readbyqxmd.com/read/29137613/preoperative-t-staging-using-ct-colonography-with-multiplanar-reconstruction-for-very-low-rectal-cancer
#10
Dai Shida, Gen Iinuma, Akira Komono, Hiroki Ochiai, Shunsuke Tsukamoto, Mototaka Miyake, Yukihide Kanemitsu
BACKGROUND: Preoperative T staging of lower rectal cancer is an important criterion for selecting intersphincteric resection (ISR) or abdominoperineal resection (APR) as well as selecting neoadjuvant therapy. The aim of this study was to evaluate the accuracy of preoperative T staging using CT colonography (CTC) with multiplanar reconstruction (MPR), in which with the newest workstation the images can be analyzed with a slice thickness of 0.5 mm. METHODS: Between 2011 and 2013, 45 consecutive patients with very low rectal adenocarcinoma underwent CTC with MPR...
November 14, 2017: BMC Cancer
https://www.readbyqxmd.com/read/29129158/practical-gastrointestinal-investigation-of-iron-deficiency-anaemia
#11
Anjan K Banerjee, Valerio Celentano, Jim Khan, Gaius Longcroft-Wheaton, Amanda Quine, Pradeep Bhandari
About 10% of oesophagogastroduodenoscopies (OGDs) and colonoscopies are done for investigation of iron deficiency anemia (IDA) . Much of the existing guidance on investigation of IDA predates CRC screening, which has driven significant improvements in colonoscopy quality and completion rates, as well as a reduction in Helicobacter pylori prevalence and increase in PPI usage, and therefore probably needs re-consideration. New investigations, e.g. CT colonography, enteroscopy and capsule endoscopy have also been introduced...
November 13, 2017: Expert Review of Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/29109391/occult-spigelian-hernia-presenting-as-inability-to-complete-colon-cancer-screening-in-a-patient-with-a-history-of-rectal-cancer
#12
Daniel Persinger, Marc D Basson
BACKGROUND While it is well known that abdominal wall hernias can pose obstacles for colonoscopy, these may not be obvious in obese patients, particularly when the hernia is in an unusual place. CASE REPORT A 62-year-old man presented with inability to complete colon cancer screening by means of colonoscopy or barium enema. On exam, he was noted to have a Spigelian hernia present in his left lower quadrant abdominal wall. CT colonography identified incarcerated sigmoid colon within the hernia accounting for his inability to complete colonoscopy or barium enema...
November 7, 2017: American Journal of Case Reports
https://www.readbyqxmd.com/read/29094497/iron-deficiency-anemia-in-older-adults-a-review
#13
REVIEW
Etienne Joosten
Anemia in older adults is a risk factor for numerous negative outcomes. There is no standard definition, but in most studies, anemia is defined as a hemoglobin value <12 g/dL for women and <13 g/dL for men. Absolute iron deficiency anemia is defined as the combination of anemia and the absence of total body iron. Serum ferritin is the most frequently used diagnostic parameter, but its concentration increases with age and in the presence of inflammatory diseases. Other laboratory tests, such as transferrin saturation, soluble transferrin receptor and the soluble transferrin receptor/ferritin index might provide useful information, but there is a wide variety in the cut-off values and interpretation of the results...
November 2, 2017: Geriatrics & Gerontology International
https://www.readbyqxmd.com/read/29040021/flexible-sigmoidoscopy-and-ct-colonography-screening-patients-experience-with-and-factors-for-undergoing-screening-insight-from-the-proteus-colon-trial
#14
Carlo Senore, Loredana Correale, Daniele Regge, Cesare Hassan, Gabriella Iussich, Marco Silvani, Arrigo Arrigoni, Lia Morra, Nereo Segnan
Purpose To compare the acceptability of computed tomographic (CT) colonography and flexible sigmoidoscopy (FS) screening and the factors predicting CT colonographic screening participation, targeting participants in a randomized screening trial. Materials and Methods Eligible individuals aged 58 years (n = 1984) living in Turin, Italy, were randomly assigned to be invited to screening for colorectal cancer with FS or CT colonography. After individuals who had died or moved away (n = 28) were excluded, 264 of 976 (27...
October 17, 2017: Radiology
https://www.readbyqxmd.com/read/28991559/imaging-and-screening-for-colorectal-cancer-with-ct-colonography
#15
REVIEW
Perry J Pickhardt
Despite being readily preventable, colorectal cancer ranks second behind only lung cancer in overall mortality. However, this situation could be reversed if screening tests that effectively detect advanced adenomas and early cancers were broadly applied. Computed tomographic colonography (CTC) reflects an ideal balance of minimal invasiveness with high-level performance, assuming all facets of the examination are appropriately addressed. Unfortunately, this promising screening test remains grossly underused...
November 2017: Radiologic Clinics of North America
https://www.readbyqxmd.com/read/28991080/prospective-trial-evaluating-the-surgical-anastomosis-at-one-year-colorectal-cancer-surveillance-ct-colonography-versus-optical-colonoscopy-and-implications-for-patient-care
#16
MULTICENTER STUDY
Perry J Pickhardt, Kristin Edwards, David H Bruining, Marc Gollub, Sonja Kupfer, Sam J Lubner, David H Kim, Eric Ross, Eileen Keenan, David S Weinberg
OBJECTIVE: The aim of this study was to compare the accuracy of CT colonography versus optical colonoscopy for neoplastic involvement at the surgical anastomosis 1 year after curative-intent colorectal cancer resection. DESIGN, SETTING, PATIENTS, AND INTERVENTIONS: Two hundred one patients (mean age, 58.6 years; 117 men, 84 women) underwent same-day contrast-enhanced CT colonography and colonoscopy approximately 1 year (mean, 12.1 months; median, 11.9 months) after colorectal cancer resection as part of a prospective, multicenter trial...
November 2017: Diseases of the Colon and Rectum
https://www.readbyqxmd.com/read/28988790/recent-diagnostic-procedures-for-colorectal-cancer-screening-are-they-cost-effective
#17
REVIEW
Mostafa Ahmed Arafa, Karim Hamda Farhat
Colorectal cancer (CRC) is the third most common cancer worldwide and the fourth most common cause of death. Reduction in mortality rates in some countries worldwide are most likely ascribed to CRC screening and/or improved treatments. We reviewed the most relevant articles which discuss the cost-effectiveness of colorectal cancer screening procedures, in particular, the recent ones through the last eight years. The effectiveness of screening estimated by discounted life years gained (LYGs) compared to no screening, differed considerably between the studies...
September 2017: Arab Journal of Gastroenterology: the Official Publication of the Pan-Arab Association of Gastroenterology
https://www.readbyqxmd.com/read/28972802/trends-in-ct-colonography-bibliometric-analysis-of-the-100-most-cited-articles
#18
Mohammed Fahim Mohammed, Tejbir Chahal, Bo Gong, Nizar Bhulani, Michael O'Keefe, Timothy O'Connell, Savvas Nicolaou, Faisal Khosa
Our purpose was to identify the top 100 cited articles, which focused on CT colonography (CTC). This list could then be analysed to establish trends in CTC research while also identifying common characteristics of highly cited works. Web of Science search was used to create a database of scientific journals using our search terms. A total of 10,597 articles were returned from this search. Articles were included if they focused on diagnostic imaging, imaging technique, cost-effectiveness analysis, clinical use, patient preference or trends in CTC...
December 2017: British Journal of Radiology
https://www.readbyqxmd.com/read/28965706/preoperative-segmental-localization-of-colorectal-carcinoma-ct-colonography-vs-optical-colonoscopy
#19
T Offermans, F J Vogelaar, M Aquarius, M L G Janssen-Heijnen, P C G Simons
BACKGROUND: Adequate preoperative segmental localization of colorectal cancer is important to indicate the right surgical treatment. Preoperative localization has become more important in the era of minimally invasive surgery. The aim of this study was to compare optical colonoscopy (OC) and CT colonography (CTC) with respect to the error rates in the segmental localization of colorectal carcinoma. METHODS: A total of 420 patients with histopathologically proven colorectal carcinoma underwent CTC between December 2006 and February 2017...
September 20, 2017: European Journal of Surgical Oncology
https://www.readbyqxmd.com/read/28870147/electronic-cleansing-in-computed-tomography-colonography-using-at-layer-identification-with-integration-of-gradient-directional-second-derivative-and-material-fraction-model
#20
Krisorn Chunhapongpipat, Ratinan Boonklurb, Bundit Chaopathomkul, Sirod Sirisup, Rajalida Lipikorn
BACKGROUND: In computed tomography colonography images, electronic cleansing (EC) is applied to remove opacified residual materials, called fecal-tagging materials (FTM), using positive-contrast tagging agents and laxative to facilitate polyp detection. METHODS: The proposed EC, EC prop , integrates the gradient directional second derivative into material fraction model to preserve submerged soft tissue (ST) under FTM. Three-material fraction model is used to remove FTM and artifacts at air-tagging (AT) layers and T-junctions where air, ST, and FTM material meet simultaneously...
September 4, 2017: BMC Medical Imaging
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