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https://www.readbyqxmd.com/read/29340980/facile-synthesis-of-chitosan-capped-mesoporous-silica-nanoparticles-a-ph-responsive-smart-delivery-platform-for-raloxifene-hydrochloride
#1
Priya V Shah, Sadhana J Rajput
An encapsulation of model drug raloxifene hydrochloride (RAL) inside the chitosan decorated pH responsive mesoporous system has a greater potential for accumulating in the tumor cells. The present study involves synthesis of surface modified mesoporous silica nanoparticles (MSN) with the aim of achieving pH sensitive drug delivery system. A silanol skeleton of MSN has been productively modified to amine intermediate which served as a firm platform to adapt chitosan grafted assembly and systematically evaluated...
January 16, 2018: AAPS PharmSciTech
https://www.readbyqxmd.com/read/29331670/circulation-of-alphacoronavirus-betacoronavirus-and-paramyxovirus-in-hipposideros-bat-species-in-zimbabwe
#2
Mathieu Bourgarel, Davies M Pfukenyi, Vanina Boué, Loïc Talignani, Ngoni Chiweshe, Fodé Diop, Alexandre Caron, Gift Matope, Dorothée Missé, Florian Liégeois
Bats carry a great diversity of zoonotic viruses with a high-impact on human health and livestock. Since the emergence of new coronaviruses and paramyxoviruses in humans (e.g. Severe Acute Respiratory Syndrome Coronavirus (SARS-CoV) and Nipah virus), numerous studies clearly established that bats can maintain some of these viruses. Improving our understanding on the role of bats in the epidemiology of the pathogens they harbour is necessary to prevent cross-species spill over along the wild/domestic/human gradient...
January 10, 2018: Infection, Genetics and Evolution
https://www.readbyqxmd.com/read/29323202/genome-based-classification-of-micromonosporae-with-a-focus-on-their-biotechnological-and-ecological-potential
#3
Lorena Carro, Imen Nouioui, Vartul Sangal, Jan P Meier-Kolthoff, Martha E Trujillo, Maria Del Carmen Montero-Calasanz, Nevzat Sahin, Darren Lee Smith, Kristi E Kim, Paul Peluso, Shweta Deshpande, Tanja Woyke, Nicole Shapiro, Nikos C Kyrpides, Hans-Peter Klenk, Markus Göker, Michael Goodfellow
There is a need to clarify relationships within the actinobacterial genus Micromonospora, the type genus of the family Micromonosporaceae, given its biotechnological and ecological importance. Here, draft genomes of 40 Micromonospora type strains and two non-type strains are made available through the Genomic Encyclopedia of Bacteria and Archaea project and used to generate a phylogenomic tree which showed they could be assigned to well supported phyletic lines that were not evident in corresponding trees based on single and concatenated sequences of conserved genes...
January 11, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29317697/physiological-response-and-microrna-expression-profiles-in-head-kidney-of-genetically-improved-farmed-tilapia-gift-oreochromis-niloticus-exposed-to-acute-cold-stress
#4
Jun Qiang, Yan T Cui, Fan Y Tao, Wen J Bao, Jie He, Xia H Li, Pao Xu, Lan Y Sun
Cold stress has a serious impact on the overwintering survival and yield of genetically improved farmed tilapia (GIFT, Oreochromis niloticus). Understanding the physiological and molecular regulation mechanisms of low-temperature adaptation is necessary to help breed new tolerant strains. The semi-lethal low temperature of juvenile GIFT at 96 h was determined as 9.4 °C. We constructed and sequenced two small RNA libraries from head kidney tissues, one for the control (CO) group and one for the 9.4 °C-stressed (LTS) group, and identified 1736 and 1481 known microRNAs (miRNAs), and 164 and 152 novel miRNAs in the CO and LTS libraries, respectively...
January 9, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29314810/is-it-ethical-to-accept-gifts-from-patients
#5
Kehinde Eniola
No abstract text is available yet for this article.
January 2018: Family Practice Management
https://www.readbyqxmd.com/read/29314029/c-g-jung-and-intuition-from-the-mindscape-of-the-paranormal-to-the-heart-of-psychology
#6
Nathalie Pilard
Intuition is central in the work, practice, and philosophical legacy of C. G. Jung. In this paper, I will first discuss the importance of intuition for Jung in the paradigm usually designated the 'paranormal'. Jung was attracted to intuition as an extra-ordinary gift or function in the traditional sense, and this is considered here in relation to his 1896-1899 Zofingia Lectures and 1902 On the Psychology and Pathology of So-called Occult Phenomena: A Psychiatric Study. A significant development then occurred in 1913, when esotericist intuitions were turned toward psychological use with Jung's Red Book...
February 2018: Journal of Analytical Psychology
https://www.readbyqxmd.com/read/29309961/local-scale-water-food-nexus-use-of-borehole-garden-permaculture-to-realise-the-full-potential-of-rural-water-supplies-in-malawi
#7
Michael O Rivett, Alistair W Halcrow, Janine Schmalfuss, John A Stark, Jonathan P Truslove, Steve Kumwenda, Kettie A Harawa, Muthi Nhlema, Chrispine Songola, Gift J Wanangwa, Alexandra V M Miller, Robert M Kalin
Local-scale opportunities to address challenges of the water-food nexus in the developing world need to be embraced. Borehole-garden permaculture is advocated as one such opportunity that involves the sustainable use of groundwater spilt at hand-pump operated borehole supplies that is otherwise wasted. Spilt water may also pose health risks when accumulating as a stagnant pond. Rural village community use of this grey-water in permaculture projects to irrigate borehole gardens is proposed to primarily provide economic benefit whereby garden-produce revenue helps fund borehole water-point maintenance...
January 5, 2018: Journal of Environmental Management
https://www.readbyqxmd.com/read/29304313/the-doctor-of-delayed-publications-the-remarkable-life-of-george-streisinger-1927-1984
#8
Máté Varga
The history of science offers multiple examples of how the perseverance of a single visionary person could open the floodgates for a whole new area of research. Zebrafish research is one of these fields with an exciting founding story, as it was the dogged persistence of one man, George Streisinger, that ultimately lifted this little fish out of the obscurity of pet shops into the pantheon of genetic model organisms. The Hungarian born Streisinger was one of the most gifted geneticists of his era and his network of mentors and friends really reads like a who-is-who of 20th century genetics...
January 5, 2018: Zebrafish
https://www.readbyqxmd.com/read/29291158/antibiotic-prophylaxis-and-dair-treatment-in-primary-total-hip-and-knee-arthroplasty-a-national-survey-in-the-netherlands
#9
Ewout S Veltman, Dirk Jan F Moojen, Rob Ghh Nelissen, Rudolf W Poolman
BACKGROUND: To prevent postoperative infection the use of systemic antibiotic prophylaxis is common ground. Type of antibiotic used and duration of prophylaxis are subject to debate. In case of suspected early periprosthetic infection a debridement, antibiotics and implant retention (DAIR) procedure is treatment of first choice. This study evaluated the antibiotic prophylaxis and DAIR treatment protocols nationwide as well as reporting of these DAIR procedures to the national joint registry...
2018: Journal of Bone and Joint Infection
https://www.readbyqxmd.com/read/29289702/study-protocol-for-log2lose-a-feasibility-randomized-controlled-trial-to-evaluate-financial-incentives-for-dietary-self-monitoring-and-interim-weight-loss-in-adults-with-obesity
#10
Corrine I Voils, Erica Levine, Jennifer M Gierisch, Jane Pendergast, Sarah L Hale, Megan A McVay, Shelby D Reed, William S Yancy, Gary Bennett, Elizabeth M Strawbridge, Allison C White, Ryan J Shaw
The obesity epidemic has negative physical, psychological, and financial consequences. Despite the existence of effective behavioral weight loss interventions, many individuals do not achieve adequate weight loss, and most regain lost weight in the year following intervention. We report the rationale and design for a 2×2 factorial study that involves financial incentives for dietary self-monitoring (yes vs. no) and/or interim weight loss (yes vs. no). Outpatients with obesity participate in a 24-week, group-based weight loss intervention...
December 28, 2017: Contemporary Clinical Trials
https://www.readbyqxmd.com/read/29287951/the-effect-of-platelet-rich-fibrin-matrix-at-the-time-of-gluteus-medius-repair-a-retrospective-comparative-study
#11
Bryan M Saltzman, Gift Ukwuani, Eric C Makhni, Jeffrey P Stephens, Shane J Nho
PURPOSE: To evaluate the effect of platelet-rich fibrin matrix (PRFM) on outcomes after surgical repair of gluteus medius tendons. METHODS: This is a retrospective review of prospectively collected data comparing patients who underwent gluteus medius repair with PRFM and patients without PRFM. Preoperative characteristics, intraoperative characteristics, and postoperative outcomes at a minimum of 1 year were recorded. Statistical analysis was performed using a multivariate analysis of variance to test for differences in continuous demographic variables and postoperative-only scores between patient groups, χ2 tests were performed for categorical variables, and a repeated-measures analysis of variance was performed to test for the effects of PRFM...
December 26, 2017: Arthroscopy: the Journal of Arthroscopic & related Surgery
https://www.readbyqxmd.com/read/29287709/angiogenesis-and-lymphangiogenesis-in-corneal-transplantation-a-review
#12
REVIEW
Wei Zhong, Mario Montana, Samuel M Santosa, Irene D Isjwara, Yu-Hui Huang, Kyu-Yeon Han, Christopher O'Neil, Ashley Wang, Maria Soledad Cortina, Jose de la Cruz, Qiang Zhou, Mark Rosenblatt, Jin-Hong Chang, Dimitri T Azar
Corneal transplantation has been proven effective for returning the gift of sight to those affected by corneal disorders such as opacity, injury, and infections that are a leading cause of blindness. Immune privilege plays an important role in the success of corneal transplantation procedures; however, immune rejection reactions do occur, and they, in conjunction with a shortage of corneal donor tissue, continue to pose major challenges. Corneal immune privilege is important to the success of corneal transplantation and closely related to the avascular nature of the cornea...
December 26, 2017: Survey of Ophthalmology
https://www.readbyqxmd.com/read/29282154/using-incentives-to-recruit-physicians-into-behavioral-trials-lessons-learned-from-four-studies
#13
Deepika Mohan, Matthew R Rosengart, Baruch Fischhoff, Derek C Angus, David J Wallace, Coreen Farris, Donald M Yealy, Amber E Barnato
OBJECTIVE: To describe lessons learned from the use of different strategies for recruiting physicians responsible for trauma triage, we summarize recruitment data from four behavioral trials run in the United States between 2010 and 2016. RESULTS: We ran a series of behavioral trials with the primary objective of understanding the influence of heuristics on physician decision making in trauma triage. Three studies were observational; one tested an intervention. The trials used different methods of recruitment (in-person vs...
December 28, 2017: BMC Research Notes
https://www.readbyqxmd.com/read/29281560/high-rate-of-return-to-cycling-after-hip-arthroscopy-for-femoroacetabular-impingement-syndrome
#14
Rachel M Frank, Gift Ukwuani, Ian Clapp, Jorge Chahla, Shane J Nho
BACKGROUND: Femoroacetabular impingement syndrome (FAIS) is most commonly diagnosed in athletes who sustain repetitive flexion and rotational loading to their hip. The purpose of this study was to evaluate a patient's ability to return to cycling after hip arthroscopy for FAIS. HYPOTHESIS: There is a high rate of return to cycling after hip arthroscopy. STUDY DESIGN: Retrospective analysis. LEVEL OF EVIDENCE: Level 4...
December 1, 2017: Sports Health
https://www.readbyqxmd.com/read/29273693/the-christmas-gift-of-genetic-uncertainty
#15
Christopher Semsarian, Ray Moynihan
No abstract text is available yet for this article.
December 22, 2017: BMJ: British Medical Journal
https://www.readbyqxmd.com/read/29248669/imaging-of-subclinical-haemopoiesis-after-stem-cell-transplantation-in-patients-with-haematological-malignancies-a-prospective-pilot-study
#16
Kirsten M Williams, Jennifer Holter-Chakrabarty, Liza Lindenberg, Quyen Duong, Sara K Vesely, Chuong T Nguyen, Joseph P Havlicek, Karen Kurdziel, Juan Gea-Banacloche, Frank I Lin, Daniele N Avila, George Selby, Christopher G Kanakry, Shibo Li, Teresa Scordino, Stephen Adler, Catherine M Bollard, Peter Choyke, Ronald E Gress
BACKGROUND: Haemopoietic stem-cell transplantation (HSCT) eradicates host haemopoiesis before venous infusion of haemopoietic stem cells (HSCs). The pathway to cellular recovery has been difficult to study in human beings because of risks associated with interventions during aplasia. We investigated whether 18F-fluorothymidine (18F-FLT) imaging was safe during allogenic HSCT and allowed visualisation of early cellular proliferation and detection of patterns of cellular engraftment after HSCT...
December 13, 2017: Lancet Haematology
https://www.readbyqxmd.com/read/29241283/-there-is-no-season-for-gifts
#17
Klaus Lieb, Cora Koch
Gifts and payments from pharmaceutical manufacturers to medical doctors constitute a conflict of interest, which may lead to an undue influence on prescribing behavior. In Germany, 35 research-based pharmaceutical companies, organized in the "Verband der forschenden Arzneimittelhersteller (VfA)" paid € 562 million to medical doctors and hospitals in 2016. Of these, € 356 million were paid for clinical trials and non-interventional studies, € 105 million for sponsored presentations and CME and € 101 million went to hospitals and other organizations for sponsoring, consulting and events...
December 2017: Deutsche Medizinische Wochenschrift
https://www.readbyqxmd.com/read/29240634/improvement-still-needed-in-sexually-transmitted-disease-testing-among-hiv-positive-medicaid-enrollees
#18
William S Pearson, Guoyu Tao, Thomas L Gift
No abstract text is available yet for this article.
January 2018: Sexually Transmitted Diseases
https://www.readbyqxmd.com/read/29240632/methods-for-sexually-transmitted-disease-prevention-programs-to-estimate-the-health-and-medical-cost-impact-of-changes-in-their-budget
#19
Harrell W Chesson, Jennifer A Ludovic, Andrés A Berruti, Thomas L Gift
BACKGROUND: The purpose of this article was to describe methods that sexually transmitted disease (STD) programs can use to estimate the potential effects of changes in their budgets in terms of disease burden and direct medical costs. METHODS: We proposed 2 distinct approaches to estimate the potential effect of changes in funding on subsequent STD burden, one based on an analysis of state-level STD prevention funding and gonorrhea case rates and one based on analyses of the effect of Disease Intervention Specialist (DIS) activities on gonorrhea case rates...
January 2018: Sexually Transmitted Diseases
https://www.readbyqxmd.com/read/29238116/a-schutzian-analysis-of-prayer-with-perspectives-from-linguistic-philosophy
#20
K Hoshikawa, M Staudigl
In this paper, we propose to analyze the phenomenon of Christian prayer by way of combining two different analytical frameworks. We start by applying Schutz's theories of "intersubjectivity," "inner time," "politheticality," and "multiple realities," and then proceed by drawing on the ideas and insights of linguistic philosophers, notably, Wittgenstein's "language-game," Austin's "speech act," and Evans's "logic of self-involvement". In conjoining these accounts, we wish to demonstrate how their combination sheds new light on understanding the phenomenon of prayer...
2017: Human Studies
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