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Primary hyperparathyroid

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https://www.readbyqxmd.com/read/28063842/relationship-between-urinary-calcium-and-bone-mineral-density-in-patients-with-calcium-nephrolithiasis
#1
Khashayar Sakhaee, Naim M Maalouf, John Poindexter, Beverley Adams-Huet, Orson W Moe
BACKGROUND: Calcium nephrolithiasis is associated with an increased risk of osteoporosis and fracture. Hypercalciuria has been assumed to be pathogenic for bone loss in kidney stone formers (KSF), although this association was shown in small cross-sectional studies. We explored the association of urine calcium (UCaV) with bone mineral density (BMD) in KSF. METHODS: We retrospectively studied BMD in KSF. Excluded were subjects with hypercalcemia, chronic bowel disease, primary hyperparathyroidism, distal renal tubular acidosis or endogenous creatinine clearance <40 ml/min...
January 4, 2017: Journal of Urology
https://www.readbyqxmd.com/read/28061891/the-dangers-of-parathyroid-biopsy
#2
Joanne Kim, Gilad Horowitz, Michael Hong, Mario Orsini, Sylvia L Asa, Kevin Higgins
BACKGROUND: We report an unusual case of a 66-year-old female with a suspicious thoracic outlet mass presenting with severe biochemical hyperparathyroidism and classic hypercalcemic symptoms of renal and bone involvement. CASE PRESENTATION: There was clinical suspicion for parathyroid carcinoma, further supported by intra-operative findings. However, the final pathology described a primary hyperceullar parathyroid lesion with pathognomonic changes secondary to fine-needle aspiration (FNA) biopsy, along with a separate parathyroid lesion likely resulting from seeding along the needle tract...
January 7, 2017: Journal of Otolaryngology—Head & Neck Surgery
https://www.readbyqxmd.com/read/28057872/a-phase-3-multicentre-randomized-double-blind-placebo-controlled-parallel-group-study-to-evaluate-the-efficacy-and-safety-of-etelcalcetide-ono-5163-amg-416-a-novel-intravenous-calcimimetic-for-secondary-hyperparathyroidism-in-japanese-haemodialysis-patients
#3
Masafumi Fukagawa, Keitaro Yokoyama, Takashi Shigematsu, Takashi Akiba, Akifumi Fujii, Takuto Kuramoto, Motoi Odani, Tadao Akizawa
BACKGROUND: Secondary hyperparathyroidism (SHPT) is a major complication associated with chronic kidney disease. We evaluated the efficacy and safety of etelcalcetide (ONO-5163/AMG 416), a novel intravenous calcimimetic, in Japanese haemodialysis patients with SHPT. METHODS: In this phase 3, multicentre, randomized, double-blind, placebo-controlled, parallel-group study, etelcalcetide was administered three times per week at an initial dose of 5 mg, and subsequently adjusted to doses between 2...
January 5, 2017: Nephrology, Dialysis, Transplantation
https://www.readbyqxmd.com/read/28033216/incremental-value-of-18f-fluorocholine-pet-ct-in-the-localization-of-double-parathyroid-adenomas
#4
Paul Lalire, Sang Ly, Sophie Deguelte, Martine Patey, David Morland
A 73-year-old man displaying primary hyperparathyroidism with severe hypercalcemia (Ca: 4.1 mmol/l, PTH > 600 pmol/l) was referred for preoperative localization of a parathyroid adenoma. Tc-pertechnetate and Tc-sestaMIBI dual tracer scintigraphy displayed a mild focal uptake in the projection of the right thyroid lobe with negative ultrasonography. F-Fluorocholine PET/CT was quickly performed considering this discrepancy and not only confirmed the scintigraphic findings but also revealed a second contralateral focus of increased uptake, both later confirmed by operative consideration (the two other parathyroid glands are considered normal by the surgeon), pathology, and intraoperative parathyroid hormone assessment...
December 28, 2016: Clinical Nuclear Medicine
https://www.readbyqxmd.com/read/28032553/using-parathyroid-hormone-spikes-during-parathyroidectomy-to-guide-intraoperative-decision-making
#5
Azadeh A Carr, Tina W Yen, Stuart D Wilson, Douglas B Evans, Tracy S Wang
BACKGROUND: Intraoperative parathyroid hormone (IOPTH) level monitoring is a useful adjunct to parathyroidectomy for primary hyperparathyroidism (pHPT). Occasionally, increases ("spikes") in IOPTH levels from the preoperative baseline parathyroid hormone may occur, which may lead to longer operative times or more extensive neck exploration or both. The aim of this study was to determine if the extent of IOPTH level increase predicts single gland disease (SGD). METHODS: This is a retrospective review of a prospective parathyroid database of patients undergoing parathyroidectomy for sporadic pHPT from 1999-2013...
October 14, 2016: Journal of Surgical Research
https://www.readbyqxmd.com/read/28032220/transoral-endoscopic-parathyroidectomy-vestibular-approach-a-novel-scarless-parathyroid-surgery
#6
Thanyawat Sasanakietkul, Pornpeera Jitpratoom, Angkoon Anuwong
BACKGROUND: Natural orifice transluminal endoscopic surgery developed for neck surgery become increasing popular. Herein, an innovative transoral endoscopic parathyroidectomy vestibular approach (TOEPVA) was developed for primary hyperparathyroidism (PHPT) and renal hyperparathyroidism (rHPT). METHODS: Incisions were made at the oral vestibule under the inferior lip. A 10-mm trocar was inserted through the center of the oral vestibule with two 5-mm trocars laterally...
December 28, 2016: Surgical Endoscopy
https://www.readbyqxmd.com/read/28017299/is-intraoperative-parathyroid-hormone-monitoring-necessary-for-primary-hyperparathyroidism-with-concordant-preoperative-imaging
#7
Iuliana D Bobanga, Christopher R McHenry
BACKGROUND: The purpose of this study was to determine if intraoperative parathyroid hormone (PTH) monitoring is necessary in patients with concordant ultrasound and sestamibi imaging. METHODS: Clinical factors, intraoperative findings and outcome were correlated with imaging results in patients with primary hyperparathyroidism who underwent parathyroidectomy with concordant ultrasound and sestamibi imaging. RESULTS: There were 127 patients with primary hyperparathyroidism and concordant imaging who underwent parathyroidectomy...
November 23, 2016: American Journal of Surgery
https://www.readbyqxmd.com/read/28012787/a-quick-reference-on-hypercalcemia
#8
REVIEW
Joao Felipe de Brito Galvão, Patricia A Schenck, Dennis J Chew
In dogs, neoplasia is the most common cause of hypercalcemia, followed by primary hyperparathyroidism, chronic kidney disease, and hypoadrenocorticism. In cats, idiopathic hypercalcemia is the most common cause, followed by chronic kidney disease and then neoplasia. Prognosis and treatment ultimately depend on the cause of the hypercalcemia.
December 21, 2016: Veterinary Clinics of North America. Small Animal Practice
https://www.readbyqxmd.com/read/28011189/primary-hyperparathyroidism-regression-associated-to-cinacalcet-therapy-proved-by-99m-tc-mibi-scintigraphy
#9
A Coloma, S Hernández-Estrada, H Bowles, N Sánchez, D Fuster, J Torregrosa
No abstract text is available yet for this article.
December 20, 2016: Revista Española de Medicina Nuclear e Imagen Molecular
https://www.readbyqxmd.com/read/28001017/improvement-of-bone-turnover-markers-and-bone-mineral-density-following-treatment-of-primary-aldosteronism
#10
Huai H Loh, Nor A Kamaruddin, Rozman Zakaria, Norlela Sukor
BACKGROUND: Recent studies showed association between hyperaldosteronism and low bone density among patients with primary aldosteronism (PA) due to secondary hyperparathyroidism. Our objective is to assess bone turnover markers (BTM) and bone mineral density (BMD) of PA patients compared to essential hypertension. METHODS: This was an open-label, prospective, case-controlled study, conducted over 12 months. Fifty-two consecutive patients referred for secondary hypertension were screened...
December 20, 2016: Minerva Endocrinologica
https://www.readbyqxmd.com/read/27998296/primary-hyperparathyroidism-in-pregnancy-treated-with-cinacalcet-a-case-report-and-review-of-the-literature
#11
Lara Vera, Silvia Oddo, Natascia Di Iorgi, Giorgio Bentivoglio, Massimo Giusti
BACKGROUND: The efficacy and safety of various modes of medical treatment for primary hyperparathyroidism in pregnancy are largely unknown. CASE PRESENTATION: We report the case of a 34-year-old white woman with primary hyperparathyroidism symptomatic for nephrolithiasis. Her serum calcium was 3.15 mmol/l and parathyroid hormone was 109.0 ng/L. Neck imaging found no pathological parathyroid tissue. Cinacalcet and cholecalciferol were started. She became pregnant 17 months later...
December 20, 2016: Journal of Medical Case Reports
https://www.readbyqxmd.com/read/27993822/calcitriol-mediated-hypercalcaemia-with-silicone-granulomas-due-to-cosmetic-injection
#12
Stephen Melnick, Ana Abaroa-Salvatierra, Mrunalini Deshmukh, Arti Patel
We present a case of a 41-year-old woman with medical history significant for urolithiasis presenting to our hospital for psychiatric evaluation due to worsening depression and suicidal ideations for the past 2 weeks. Initial laboratory results show hypercalcaemia of 13.5 mg/mL that led to consulting internal medicine. On further questioning, the patient admitted to cosmetic silicone injections in her buttocks which were causing calcium deposition under her skin, leading to disfigurement of the sacrum and lumbar regions...
December 19, 2016: BMJ Case Reports
https://www.readbyqxmd.com/read/27989606/improving-diagnostic-recognition-of-primary-hyperparathyroidism-with-machine-learning
#13
Yash R Somnay, Mark Craven, Kelly L McCoy, Sally E Carty, Tracy S Wang, Caprice C Greenberg, David F Schneider
BACKGROUND: Parathyroidectomy offers the only cure for primary hyperparathyroidism, but today only 50% of primary hyperparathyroidism patients are referred for operation, in large part, because the condition is widely under-recognized. The diagnosis of primary hyperparathyroidism can be especially challenging with mild biochemical indices. Machine learning is a collection of methods in which computers build predictive algorithms based on labeled examples. With the aim of facilitating diagnosis, we tested the ability of machine learning to distinguish primary hyperparathyroidism from normal physiology using clinical and laboratory data...
December 15, 2016: Surgery
https://www.readbyqxmd.com/read/27979480/location-of-abnormal-parathyroid-glands-lessons-from-810-parathyroidectomies
#14
Melissa LoPinto, Gustavo A Rubio, Zahra F Khan, Tanaz M Vaghaiwalla, Josefina C Farra, John I Lew
BACKGROUND: Primary hyperparathyroidism (pHPT) is commonly treated with targeted parathyroidectomy (PTX) guided by preoperative imaging and intraoperative parathormone monitoring. Despite advanced imaging techniques, failure of parathyroid localization still occurs. This study determines the anatomical distribution of single abnormal parathyroid glands, which may help direct the surgeon in PTX when preoperative localization is unsuccessful. METHODS: A retrospective review of prospectively collected data of 810 patients with pHPT who underwent initial PTX at a tertiary medical center was performed...
January 2017: Journal of Surgical Research
https://www.readbyqxmd.com/read/27979029/chronic-autoimmune-urticaria-as-the-presenting-manifestation-of-primary-hyperparathyroidism
#15
Amie Harvey, Karen Kaufman, Jason Daily
No abstract text is available yet for this article.
December 2016: Annals of Allergy, Asthma & Immunology
https://www.readbyqxmd.com/read/27974978/palatal-swelling-a-diagnostic-enigma
#16
Ramalingam Suganya, Narasimhan Malathi, Harikrishnan Thamizhchelvan, Subramaniam Ramkumar, G V V Giri
Giant cell tumor (GCT) of bone is a giant-cell-rich bony lesion associated with abundant multinucleated osteoclast-type giant cells. It is a primary neoplasm of bone with characteristic clinical, radiological, and pathological features. It is an expansive and lytic lesion without periosteal reaction and prominent peripheral sclerosis. Giant cells are also seen in other diseases like giant cell granuloma of the jaws, traumatic bone cyst, aneurysmal bone cyst, and jaw tumor of hyperparathyroidism. We present a unique case of GCT of palate in a 30-year-old female...
2016: Case Reports in Dentistry
https://www.readbyqxmd.com/read/27967299/thiazide-treatment-in-primary-hyperparathyroidism-a-new-indication-for-an-old-medication
#17
Gloria Tsvetov, Dania Hirsch, Ilan Shimon, Carlos Benbassat, Hiba Masri-Iraqi, Alexander Gorshtein, Dana Herzberg, Tzippy Shochat, Ilana Shraga-Slutzky, Talia Diker-Cohen
CONTEXT: There is no available targeted therapy for control of hypercalciuria in nonoperable patients with primary hyperparathyroidism (PHPT). Thiazide diuretics are used for idiopathic hypercalciuria but avoided in PHPT to prevent exacerbating hypercalcemia. Nevertheless, several reports suggested that thiazides may be safe in patients with PHPT. OBJECTIVE: To test the safety and efficacy of thiazides in PHPT. DESIGN: Retrospective analysis of medical records...
December 14, 2016: Journal of Clinical Endocrinology and Metabolism
https://www.readbyqxmd.com/read/27957351/the-biochemical-profile-of-familial-hypocalciuric-hypercalcemia-and-primary-hyperparathyroidism-during-pregnancy-and-lactation-two-case-reports-and-review-of-the-literature
#18
S A Ghaznavi, N M A Saad, L E Donovan
Background. Primary hyperparathyroidism (PHPT) and Familial Hypocalciuric Hypercalcemia (FHH) result in different maternal and fetal complications in pregnancy. Calcium to creatinine clearance ratio (CCCR) is commonly used to help distinguish these two conditions. Physiological changes in calcium handling during pregnancy and lactation can alter CCCR, making it a less useful tool to distinguish PHPT from FHH. Cases. A 25-year-old female presented with hypercalcemia and an inappropriately normal PTH. Her CCCR was 0...
2016: Case Reports in Endocrinology
https://www.readbyqxmd.com/read/27955848/-intrathyroidal-location-of-parathyroid-glands-atypical-presentation-of-multiple-endocrine-neoplasia-type-1-syndrome
#19
Marta de la Fuente-Bartolomé, Alejando Moreno-Bargueiras, Irene Osorio-Silla, José Ignacio Martínez-Pueyo, Felipe de la Cruz-Vigo, Lara Gutiérrez-Ashling
BACKGROUND: The most common manifestation of MEN 1 syndrome is primary hyperparathyroidism (PHPT) with parathyroid multiglandular affectation. The intrathyroidal situation represents 3-4% of all glands, and it is the second most frequent location in the cervical ectopias. CLINICAL CASE: 11 year old patient, with a family history of MEN1 syndrome and carrier of this same mutation. Patient presents HPTP with osteopenia. The cervical ultrasound shows three compatible images with pathological parathyroid glands (bilateral lower and upper left)...
December 9, 2016: Cirugia y Cirujanos
https://www.readbyqxmd.com/read/27955840/persistence-and-relapse-after-parathyroidectomy-in-non-family-primary-hyperparathyroidism
#20
José Ruiz, Antonio Ríos, José Manuel Rodríguez
No abstract text is available yet for this article.
December 9, 2016: Medicina Clínica
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