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Primary hyperparathyroid

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https://www.readbyqxmd.com/read/29241464/-diagnostic-approach-and-treatment-of-primary-hyperparathyroidism
#1
W Y van der Plas, M E Noltes, A W M A Schaeffers, A H Brouwers, A N A van der Horst-Schrivers, S Kruijff
- Primary hyperparathyroidism (PHPT) is characterised by elevated serum calcium levels due to elevated levels, or insufficient suppression, of parathyroid hormone (PTH).- The incidence of PHPT has increased in recent years. This is mainly the result of more frequently performed routine measurements of serum calcium, e.g. as part of postmenopausal screening.- The classically described features of PHPT - bones and stones - are not always observed and most patients are asymptomatic.- Diagnosis of PHPT is only established by biochemical testing, not by imaging...
2017: Nederlands Tijdschrift Voor Geneeskunde
https://www.readbyqxmd.com/read/29239035/heritable-forms-of-primary-hyperparathyroidism-a-current-perspective
#2
REVIEW
Ronald A DeLellis, Shamlal Mangray
Primary hyperparathyroidism (PHPT) is one of the most common of all endocrine disorders encountered by the practising histopathologist. The vast majority of lesions are sporadic in nature, approximately 85% of which are parathyroid adenomas, while hyperplasia and carcinoma account for 10-15% and fewer than 1%, of cases, respectively. Heritable forms of PHPT are much less common and present challenges both to clinicians and pathologists, particularly when they are the presenting feature of an endocrine syndrome...
January 2018: Histopathology
https://www.readbyqxmd.com/read/29235733/intraoperative-parathyroid-aspiration-and-parathyroid-hormone-assay-during-parathyroidectomy-for-primary-hyperparathyroidism
#3
Miki Paker, Shani Fisher, Salim Mazzawi, Raul Kolodner, Dror Ashkenazi
BACKGROUND: Direct aspiration from suspected pathological tissue and rapid parathyroid hormone analysis may offer a reliable, cost effective alternative to currently used "gold standard" tests. OBJECTIVES: To validate the accuracy of intraoperative measurements of parathyroid hormone levels in parathyroid adenomas. METHODS: A prospective study included 22 patients diagnosed with primary hyperparathyroidism who underwent parathyroidectomy due to an adenoma or hyperplasia...
December 2017: Israel Medical Association Journal: IMAJ
https://www.readbyqxmd.com/read/29229131/racial-disparities-in-the-cost-of-surgical-care-for-parathyroidectomy
#4
Samuel Jang, Meagan Mandabach, Zviadi Aburjania, Courtney J Balentine, Herbert Chen
BACKGROUND: Parathyroidectomy is the only curative therapy for hyperparathyroidism, but its cost and variation in use among different racial and ethnic groups are largely unexamined. The purpose of this study was to examine the association between race and ethnicity and the total hospital cost of parathyroidectomy. METHODS: This retrospective study included 899 consecutive complete parathyroidectomies in our institution between September 2011 and July 2016. Total length of stay and cost were primary outcomes...
January 2018: Journal of Surgical Research
https://www.readbyqxmd.com/read/29227640/raman-spectroscopy-applied-to-parathyroid-tissues-a-new-diagnostic-tool-to-discriminate-normal-tissue-from-adenoma
#5
Andrea Palermo, Marco Fosca, Gaia Tabacco, Federico Marini, Valerio Graziani, Maria Carla Santarsia, Filippo Longo, Angelo Lauria, Roberto Cesareo, Isabella Giovannoni, Chiara Taffon, Massimiliano Rocchia, Silvia Manfrini, Pierfilippo Crucitti, Paolo Pozzilli, Anna Crescenzi, Julietta V Rau
Primary hyperparathyroidism is an endocrine disorder characterized by autonomous production of parathyroid hormone. Patients with the symptomatic disease should be referred for parathyroidectomy. However, the distinction between the pathological condition and the benign one is very challenging in the surgical setting; therefore, accurate recognition is important to ensure success during minimally invasive surgery. At present, all intraoperative techniques significantly increase surgical time and, consequently, cost...
December 11, 2017: Analytical Chemistry
https://www.readbyqxmd.com/read/29225978/coexistence-of-gh-producing-pituitary-macroadenoma-and-meningioma-in-a-patient-with-multiple-endocrine-neoplasia-type-1-with-hyperglycemia-and-ketosis-as-first-clinical-sign
#6
A Herrero-Ruiz, H S Villanueva-Alvarado, J J Corrales-Hernández, C Higueruela-Mínguez, J Feito-Pérez, J M Recio-Cordova
We present the clinical case of a patient who was admitted with an onset of diabetes mellitus (DM) with associated ketosis and whose clinical, hormonal, and radiological evolution revealed the presence of primary hyperparathyroidism, pancreatic neuroendocrine tumor, and GH-producing pituitary macroadenoma in the context of multiple endocrine neoplasia type 1 (MEN1). DM is relatively common in cases of acromegaly, but it is not generally associated with ketosis. Simultaneously, the patient presented a meningioma, which is associated with pituitary macroadenoma only in extremely rare cases...
2017: Case Reports in Endocrinology
https://www.readbyqxmd.com/read/29225260/a-case-of-hyperparathyroidism-jaw-tumor-syndrome-confirmed-by-preoperative-genetic-testing
#7
Kenji Koikawa, Yosuke Okada, Hiroko Mori, Mayuko Kawaguchi, Shinya Uchino, Yoshiya Tanaka
We herein report the case of a young woman who was diagnosed with primary hyperparathyroidism and in whom genetic testing confirmed a diagnosis of hyperparathyroidism-jaw tumor syndrome. Familial hyperparathyroidism was suspected based on the patient's young age at the onset of the disease.Thus, genetic testing was performed.It showed a germline mutation in the HRPT2/CDC73 gene and confirmed the diagnosis of hyperparathyroidism-jaw tumor syndrome. Total parathyroidectomy was performed to prevent recurrence...
December 8, 2017: Internal Medicine
https://www.readbyqxmd.com/read/29225207/parathyroid-carcinoma-occurred-in-two-glands-in-multiple-endocrine-neoplasia-1-a-report-on-a-rare-case
#8
Yoko Omi, Kiyomi Horiuchi, Kento Haniu, Momoko Tokura, Erin Nagai, Osamu Isozaki, Yoji Nagashima, Takahiro Okamoto
Primary hyperparathyroidism is the most common hormonal manifestation associated with multiple endocrine neoplasia 1 (MEN1). It is generally caused by parathyroid hyperplasia, and parathyroid carcinoma is rare. Here, we report a case of MEN1 with parathyroid carcinoma in two parathyroid glands causing primary hyperparathyroidism. A 40-year-old man with primary hyperparathyroidism due to MEN1 underwent a total parathyroidectomy. His corrected calcium and intact PTH (i-PTH) serum levels were 10.8 mg/dL and 203 pg/mL, respectively...
December 8, 2017: Endocrine Journal
https://www.readbyqxmd.com/read/29221681/hypercalcemic-crisis-and-primary-hyperparathyroidism-cause-of-an-unusual-electrical-storm
#9
Tatiana Guimarães, Miguel Nobre Menezes, Diogo Cruz, Sónia do Vale, Armando Bordalo, Arminda Veiga, Fausto J Pinto, Dulce Brito
Hypercalcemia is a known cause of heart rhythm disorders, however its association with ventricular arrhythmias is rare. The authors present a case of a fifty-three years old male patient with a ischemic and ethanolic dilated cardiomyopathy, and severely reduced ejection fraction, carrier of cardiac resynchronization therapy (CRT) with cardioverter defibrillator (ICD), admitted in the emergency department with an electrical storm, with multiple appropriated ICD shocks, refractory to antiarrhythmic therapy. In the etiological investigation was documented severe hypercalcemia secondary to primary hyperparathyroidism undiagnosed until then...
December 5, 2017: Portuguese Journal of Cardiology: An Official Journal of the Portuguese Society of Cardiology
https://www.readbyqxmd.com/read/29221466/unusual-pathological-fracture-of-the-clavicle-revealing-primary-hyperparathyroidism-a-case-report
#10
Yassir Benameur, Hasnae Guerrouj, Imad Ghfir, Nouzha Ben Rais Aouad
BACKGROUND: Primary hyperparathyroidism revealed by a pathological fracture is very uncommon; in the majority of cases the discovery of lytic bone lesions on imaging examinations evokes in the clinician first a neoplastic etiology and a metabolic origin is often omitted. This case report adds to the existing literature as it describes an unusual presentation of primary hyperparathyroidism. CASE PRESENTATION: We report a case of a 50-year-old Moroccan man, without any known tumor, who presented a fracture of his left clavicle with multiple osteolytic lesions on computed tomography suggesting bone metastases...
December 9, 2017: Journal of Medical Case Reports
https://www.readbyqxmd.com/read/29217931/hyper-parathyroidisim-jaw-tumor-syndrome-a-rare-condition-of-incongruous-features
#11
Manchil P Redwin Dhas, Kannan S Karthiga, Joy E Tatu, Sherubin J Eugenia
Background: Hyperparathyroidism-Jaw Tumor (HPT-JT) syndrome is a rare genetic disorder bearing both a germline and a somatic CDC73 mutation (formerly known as HRPT2), which has been mapped to chromosome 1q25-q31. The association of jaw ossifying fibroma with primary hyperparathyroidisim (PHPT) is typical of HPT-JT. It may also include cystic and neoplastic renal abnormalities and uterine tumors. Case Details: Here, we report a case of HPT-JT with an initial presentation of declination in reproductive fitness...
May 2017: Ethiopian Journal of Health Sciences
https://www.readbyqxmd.com/read/29209851/elevated-parathyroid-hormone-levels-after-successful-parathyroidectomy-for-primary-hyperparathyroidism-a-clinical-review
#12
REVIEW
Roberto de la Plaza Llamas, José Manuel Ramia Ángel, Vladimir Arteaga Peralta, Cristina García Amador, Aylhín Joana López Marcano, Aníbal Armando Medina Velasco, Begoña González Sierra, Alba Manuel Vázquez, Raquel Aránzazu Latorre Fragua
INTRODUCTION: Surgery for primary hyperparathyroidism (PHPT) is traditionally deemed to be successful if serum calcium levels return to normal 6 months after parathyroidectomy. Regular monitoring of serum calcium and parathyroid hormone (PTH) in the follow-up of patients after parathyroidectomy for PHPT has drawn attention to the presence of a normocalcemic group of patients with elevated PTH (NCePTH) during the post-operative period. The etiological factors and mechanisms underlying this condition, its consequences, and the possibility of treatment are the object of this study...
December 5, 2017: European Archives of Oto-rhino-laryngology
https://www.readbyqxmd.com/read/29207788/hyperparathyroidism-during-pregnancy-a-diagnostic-and-therapeutic-challenge
#13
Richa Sharma, Bhanupriya, Vishnu Bhartiya, Kiran Guleria, Amita Suneja
Primary Hyperparathyroidism (PHP) is a rare event in pregnancy; Maternal complications in PHP patients can be as high as 67%. It can be overlooked easily because of many similar complaints shared by hyperparathyroidism and pregnancy such as nausea and vomiting, gastritis, bone aches, easy fatigability. Hypercalcemic crisis can develop resulting in coma and death. Neonatal effects are tetany and death in about 80% of cases. We report a case, of an antenatal woman at 30 weeks gestation with complains of painful swelling in left lower jaw and below right knee, pain over right hip joint and frequent episodes of gastritis...
September 2017: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/29204278/cured-primary-hyperparathyroidism-after-fine-needle-aspiration-biopsy-induced-parathyroid-disappearance
#14
Elda Kara, Elisa Della Valle, Sara De Vincentis, Vincenzo Rochira, Bruno Madeo
Spontaneous or fine-needle aspiration (FNAB)-induced remission of primary hyperparathyroidism (PHPT) may occur, especially for cystic lesions. However, the disease generally relapses over a short time period. We present a case of PHPT due to an enlarged hyperfunctioning parathyroid that underwent long-term (almost 9 years) clinical and ultrasonographic remission after the disappearance of the lesion following ultrasound (US)-assisted FNAB. A 67-year-old woman with PHPT underwent biochemical and US examinations that confirmed the diagnosis and showed a lesion suggestive for parathyroid adenoma or hyperplasia...
2017: Endocrinology, Diabetes & Metabolism Case Reports
https://www.readbyqxmd.com/read/29198075/characteristics-management-and-outcome-of-primary-hyperparathyroidism-at-a-single-clinical-center-from-2005-to-2016
#15
B Sun, B Guo, B Wu, J Kang, X Deng, Z Zhang, Y Fan
This study presents the clinical and biochemical profiles of patients with PHPT between 2005 and 2016 at our center. Most PHPT patients in China show symptomatic features. The number of symptomatic and asymptomatic patients increased during that time, and the number of individuals with parathyroid carcinoma is now increasing. INTRODUCTION: Over the last decade, the prevalence of primary hyperparathyroidism (PHPT) has increased sharply, and the number of individuals with parathyroid cancer is still trending upward...
December 3, 2017: Osteoporosis International
https://www.readbyqxmd.com/read/29189860/-false-negative-spect-parathyroid-scintigraphy-with-sestamibi-in-patients-with-primary-hyperparathyroidism
#16
Gabriela Paillahueque, Teresa Massardo, Marcela Barberán, Gerson Ocares, Iván Gallegos, Luis Toro, A Verónica Araya
BACKGROUND: 99mTc-sestamibi parathyroid SPECT scintigraphy is a useful tool in the pre-operative study of hyperparathyroidism. False negatives (FN) have been reported in 5.7-14% of the examinations. AIM: To characterize 99mTc-sestamibi FN in cases referred for primary hyperparathyroidism (PHP) to a university hospital. MATERIAL AND METHODS: Descriptive retrospective analysis. We included patients with PHP, studied with SPECT scintigraphy, operated at our center between 2008 and 2015...
August 2017: Revista Médica de Chile
https://www.readbyqxmd.com/read/29188159/three-dimensional-computed-tomography-reconstruction-for-revision-parathyroidectomy
#17
Navdeep R Sayal, Ryan J Brisson, Kenneth Richey, Christine Lepoudre
A 57-year-old man presented with persistent hyperparathyroidism following primary parathyroidectomy. A four-dimensional computed tomography scan with three-dimensional reconstruction showed two parathyroid glands (one right and one left) and anatomic variation from previous surgery. Revision surgery was performed revealing the parathyroid glands as expected from the preoperative three-dimensional reconstruction. After surgery, the patient recovered well, and preoperative symptoms resolved. The use of three-dimensional computed tomography reconstruction provided accurate localization of the parathyroid glands and surrounding anatomic structures...
September 26, 2017: Curēus
https://www.readbyqxmd.com/read/29183364/unusual-presentations-of-functional-parathyroid-cysts-a-case-series-and-review-of-the-literature
#18
Youssef El-Housseini, Martin Hübner, Ariane Boubaker, Jan Bruegger, Maurice Matter, Olivier Bonny
BACKGROUND: Cysts of parathyroid origin are sometimes encountered and can easily be mistaken as thyroidal cysts. Functional parathyroid cysts, with symptoms and signs of hyperparathyroidism, are rare and may be a diagnostic challenge to clinicians. We report here on three cases of functional parathyroid cysts that illustrate diagnosis difficulties related to unusual clinical presentations in three Caucasian women, including negative parathyroid scintigraphy. CASE PRESENTATIONS: Patient 1, an 87-year-old Caucasian woman presented with confusion and dysphagia...
November 29, 2017: Journal of Medical Case Reports
https://www.readbyqxmd.com/read/29181209/ureteropelvic-junction-obstruction-and-parathyroid-adenoma-coincidence-or-link
#19
Salah Termos, Majd AlKabbani, Tim Ulinski, Sami Sanjad, Henri Kotobi, Francois Chalard, Bilal Aoun
Congenital ureteropelvic junction obstruction (UPJO) is the most common cause of upper urinary tract obstruction in children. It is generally diagnosed in the routine work-up during antenatal period and is characterized by spontaneous recovery. It can be associated with urolithiasis; hence further investigation should be carried out. We report the case of a 15-year-old boy, who is known to have right UPJO, presented with right renal colic and discovered to have bilateral kidney stones. Further studies showed primary hyperparathyroidism and genetic analysis revealed a CDC73 mutation (initially HRPT2)...
2017: Case Reports in Nephrology
https://www.readbyqxmd.com/read/29181196/99mtc-sestamibi-123i-subtraction-spect-ct-in-parathyroid-scintigraphy-is-additional-pinhole-imaging-useful
#20
Virpi Tunninen, Pekka Varjo, Tomi Kauppinen, Anu Holm, Hannu Eskola, Marko Seppänen
Objectives: This retrospective study evaluated whether the use of additional anterior 99mTc-sestamibi/123I pinhole imaging improves the outcome of 99mTc-sestamibi/123I subtraction SPECT/CT in parathyroid scintigraphy (PS). Materials and Methods: PS using simultaneous dual-isotope subtraction methods and an acquisition protocol combining SPECT/CT and planar pinhole imaging was performed for 175 patients with primary or secondary hyperparathyroidism. All patients who proceeded to surgery with complete postsurgery laboratory findings were included in this study (n = 94)...
2017: International Journal of Molecular Imaging
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