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https://www.readbyqxmd.com/read/29342146/a-theory-of-how-active-behavior-stabilises-neural-activity-neural-gain-modulation-by-closed-loop-environmental-feedback
#1
Christopher L Buckley, Taro Toyoizumi
During active behaviours like running, swimming, whisking or sniffing, motor actions shape sensory input and sensory percepts guide future motor commands. Ongoing cycles of sensory and motor processing constitute a closed-loop feedback system which is central to motor control and, it has been argued, for perceptual processes. This closed-loop feedback is mediated by brainwide neural circuits but how the presence of feedback signals impacts on the dynamics and function of neurons is not well understood. Here we present a simple theory suggesting that closed-loop feedback between the brain/body/environment can modulate neural gain and, consequently, change endogenous neural fluctuations and responses to sensory input...
January 17, 2018: PLoS Computational Biology
https://www.readbyqxmd.com/read/29340757/comparing-brain-activity-patterns-during-spontaneous-exploratory-and-cue-instructed-learning-using-single-photon-emission-computed-tomography-spect-imaging-of-regional-cerebral-blood-flow-in-freely-behaving-rats
#2
A Mannewitz, J Bock, S Kreitz, A Hess, J Goldschmidt, H Scheich, Katharina Braun
Learning can be categorized into cue-instructed and spontaneous learning types; however, so far, there is no detailed comparative analysis of specific brain pathways involved in these learning types. The aim of this study was to compare brain activity patterns during these learning tasks using the in vivo imaging technique of single photon-emission computed tomography (SPECT) of regional cerebral blood flow (rCBF). During spontaneous exploratory learning, higher levels of rCBF compared to cue-instructed learning were observed in motor control regions, including specific subregions of the motor cortex and the striatum, as well as in regions of sensory pathways including olfactory, somatosensory, and visual modalities...
January 16, 2018: Brain Structure & Function
https://www.readbyqxmd.com/read/29339326/surround-inhibition-in-the-primary-motor-cortex-is-task-specifically-modulated-in-non-professional-musicians-but-not-in-healthy-controls-during-real-piano-playing
#3
Gonzalo Márquez, Martin Keller, Jesper Lundbye-Jensen, Wolfgang Taube
Research has indicated that at the onset of a finger movement, unwanted contractions of adjacent muscles are prevented by inhibiting the cortical areas representing these muscles. This so-called surround inhibition (SI) seems relevant for the performance of selective finger movements but may not be necessary for tasks involving functional coupling between different finger muscles. Therefore, the present study compared SI between isolated finger movement and complex selective finger movements while playing a three-finger sequence on the piano in 9 non-professional musicians and 10 untrained control participants...
January 12, 2018: Neuroscience
https://www.readbyqxmd.com/read/29339006/food-allergy-induces-alteration-in-brain-inflammatory-status-and-cognitive-impairments
#4
Liqing Zhou, Long Chen, Xiaohuan Li, Tingyu Li, Zhifang Dong, Yu Tian Wang
Accumulating evidence supports an increase in emotional and behavioral problems in patients with food allergy, but the underlying mechanism remains poorly understood. Here we found that in addition to inducing an increase of allergic factors in serum, food allergy also increased levels of antigen-specific immunoglobulins and mast cell marker in the brain. In particular, food allergy increased the number of total microglia and the percentage of active microglia in the cerebral cortex and hippocampal CA1 areas, and induced the increase of TNF-α in the cerebral cortex...
January 12, 2018: Behavioural Brain Research
https://www.readbyqxmd.com/read/29338380/transplantation-of-human-neural-progenitor-cells-reveals-structural-and-functional-improvements-in-the-spastic-han-wistar-rat-model-of-ataxia
#5
Ruslan L Nuryyev, Toni L Uhlendorf, Wesley Tierney, Suren Zatikyan, Oleg Kopyov, Alex Kopyov, Jessica Ochoa, William Van Trigt, Cindy S Malone, Randy W Cohen
The use of regenerative medicine to treat nervous system disorders like ataxia has been proposed to either replace or support degenerating neurons. In this study, we assessed the ability of human neural progenitor cells (hNPCs) to repair and restore the function of dying neurons within the spastic Han-Wistar rat (sHW), a model of ataxia. The sHW rat suffers from neurodegeneration of specific neurons, including cerebellar Purkinje cells and hippocampal CA3 pyramidal cells leading to the observed symptoms of forelimb tremor, hind-leg rigidity, gait abnormality, motor incoordination, and a shortened life span...
November 2017: Cell Transplantation
https://www.readbyqxmd.com/read/29338060/biofeedback-effect-of-hybrid-assistive-limb-in-stroke-rehabilitation-a-proof-of-concept-study-using-functional-near-infrared-spectroscopy
#6
Kazuya Saita, Takashi Morishita, Hisatomi Arima, Koichi Hyakutake, Toshiyasu Ogata, Kenji Yagi, Etsuji Shiota, Tooru Inoue
INTRODUCTION: Robot-assisted rehabilitation has been increasingly drawing attention in the field of neurorehabilitation. The hybrid assistive limb (HAL) is an exoskeleton robot developed based on the "interactive biofeedback" theory, and several studies have shown its efficacy for patients with stroke. We aimed to investigate the mechanisms of the facilitative effect of neurorehabilitation using a single-joint HAL (HAL-SJ) and functional near-infrared spectroscopy (fNIRS). MATERIALS AND METHODS: Subacute stroke patients admitted to our hospital were assessed in this study for HAL eligibility...
2018: PloS One
https://www.readbyqxmd.com/read/29337235/frequency-specific-effective-connectivity-in-subjects-with-cerebral-infarction-as-revealed-by-nirs-method
#7
Qianying Liu, Bitian Wang, Ying Liu, Zeping Lv, Wenhao Li, Zengyong Li, Yubo Fan
A connectivity-based approach can highlight the network reorganization in the chronic phases after stroke and contributes to the development of therapeutic interventions. Using dynamic Bayesian inference, this study aimed to assess the effective connectivity(EC)in various frequency bands through the near-infrared spectroscopy(NIRS) method in subjects with cerebral infarction(CI). A phase-coupling model was established based on phase information extracted using the wavelet transform of NIRS signals. Coupling strength and the main coupling direction were estimated using dynamic Bayesian inference...
January 11, 2018: Neuroscience
https://www.readbyqxmd.com/read/29337147/neuronal-pten-deletion-in-adult-cortical-neurons-triggers-progressive-growth-of-cell-bodies-dendrites-and-axons
#8
Erin A Gallent, Oswald Steward
Deletion of the phosphatase and tensin (PTEN) gene in neonatal mice leads to enlargement of the cell bodies of cortical motoneurons (CMNs) in adulthood (Gutilla et al., 2016). Here, we assessed whether PTEN deletion in adult mice would trigger growth of mature neurons. PTEN was deleted by injecting AAV-Cre into the sensorimotor cortex of adult transgenic mice with a lox-P flanked exon 5 of the PTEN gene and Cre-dependent reporter gene tdTomato. PTEN-deleted CMN's identified by tdT expression and retrograde labeling with fluorogold (FG) were significantly enlarged four months following PTEN deletion, and continued to increase in size through the latest time intervals examined (12-15 months post-deletion)...
January 11, 2018: Experimental Neurology
https://www.readbyqxmd.com/read/29336136/international-clinical-protocol-on-vestibular-disorders-dizziness
#9
Kostiantyn Trinus, Claus-Frenz Claussen
26-28 May at 43 Congress of Neurootological and Equilibriometric Society (Budapest, Hungary) International Clinical Protocol on Vestibular Disorders (Dizziness) being discussed and accepted as Consensus Document. Cochrane reports estimates that dizziness has prevalence of 22.9% in the last 12 months and an incidence of 3.1%. Only 1.8% of adults consulted a physician in the last 12 months. Cochrane reviews suggest that the evidence base for dizziness evaluation is weak, thus necessitates the creation of evidence-based document...
December 1, 2017: International Tinnitus Journal
https://www.readbyqxmd.com/read/29335882/clinical-response-to-vim-s-thalamic-stereotactic-radiosurgery-for-essential-tremor-is-associated-with-distinctive-functional-connectivity-patterns
#10
Constantin Tuleasca, Elena Najdenovska, Jean Régis, Tatiana Witjas, Nadine Girard, Jérôme Champoudry, Mohamed Faouzi, Jean-Philippe Thiran, Meritxell Bach Cuadra, Marc Levivier, Dimitri Van De Ville
INTRODUCTION: Essential tremor (ET) is the most common movement disorder. Drug-resistant ET can benefit from standard surgical stereotactic procedures (deep brain stimulation, thalamotomy) or minimally invasive high-intensity focused ultrasound (HIFU) or stereotactic radiosurgical thalamotomy (SRS-T). Resting-state fMRI (rs-fMRI) is a non-invasive imaging method acquired in absence of a task. We examined whether rs-fMRI correlates with tremor score on the treated hand (TSTH) improvement 1 year after SRS-T...
January 15, 2018: Acta Neurochirurgica
https://www.readbyqxmd.com/read/29335516/an-evaluation-of-the-effect-of-pulse-shape-on-grey-and-white-matter-stimulation-in-the-rat-brain
#11
Marjolijn Deprez, Kelly Luyck, Laura Luyten, Tim Tambuyzer, Bart Nuttin, Myles Mc Laughlin
Despite the current success of neuromodulation, standard biphasic, rectangular pulse shapes may not be optimal to achieve symptom alleviation. Here, we compared stimulation efficiency (in terms of charge) between complex and standard pulses in two areas of the rat brain. In motor cortex, Gaussian and interphase gap stimulation (IPG) increased stimulation efficiency in terms of charge per phase compared with a standard pulse. Moreover, IPG stimulation of the deep mesencephalic reticular formation in freely moving rats was more efficient compared to a standard pulse...
January 15, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29335359/recruitment-of-additional-corticospinal-pathways-in-the-human-brain-with-state-dependent-paired-associative-stimulation
#12
Dominic Kraus, Georgios Naros, Robert Guggenberger, Maria Teresa Leão, Ulf Ziemann, Alireza Gharabaghi
Standard brain stimulation protocols modify human motor cortex excitability by modulating the gain of the activated corticospinal pathways. However, the restoration of motor function following lesions of the corticospinal tract requires also the recruitment of additional neurons to increase the net corticospinal output. For this purpose, we investigated a novel protocol based on brain state-dependent paired associative stimulation.Motor imagery (MI)-related electroencephalography was recorded in healthy males and females for brain state-dependent control of both cortical and peripheral stimulation in a brain-machine interface environment...
January 15, 2018: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
https://www.readbyqxmd.com/read/29335072/rebound-excitability-mediates-motor-abnormalities-in-parkinson-s-disease
#13
Jeongjin Kim, Daesoo Kim
Parkinson's disease (PD) is a debilitating disorder resulting from loss of dopamine neurons. In dopamine deficient state, the basal ganglia increases inhibitory synaptic outputs to the thalamus. This increased inhibition by the basal ganglia output is known to reduce firing rate of thalamic neurons that relay motor signals to the motor cortex. This 'rate model' suggests that the reduced excitability of thalamic neurons is the key for inducing motor abnormalities in PD patients. We reveal that in response to inhibition, thalamic neurons generate rebound firing at the end of inhibition...
January 16, 2018: BMB Reports
https://www.readbyqxmd.com/read/29334787/analysis-of-endocannabinoid-receptors-and-enzymes-in-the-post-mortem-motor-cortex-and-spinal-cord-of-amyotrophic-lateral-sclerosis-patients
#14
Francisco Espejo-Porras, Javier Fernández-Ruiz, Eva de Lago
OBJECTIVE: We have investigated the endocannabinoid system in the motor cortex of motor neuron disease (MND) patients. METHODS: Post-mortem samples from MND patients and controls were used for immunostaining and/or Western blotting analysis of endocannabinoid elements. RESULTS: We did not find any evidence of neuronal losses in the motor cortex of MND patients, but elevations in glial markers Iba-1 and GFAP were evident. We found no changes in FAAH and MAGL enzymes and in the CB1 receptor, which correlated with the lack of cortical neuron death...
January 15, 2018: Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration
https://www.readbyqxmd.com/read/29334647/time-resolved-decoding-of-planned-delayed-and-immediate-prehension-movements
#15
Giacomo Ariani, Nikolaas N Oosterhof, Angelika Lingnau
Different contexts require us either to react immediately, or to delay (or suppress) a planned movement. Previous studies that aimed at decoding movement plans typically dissociated movement preparation and execution by means of delayed-movement paradigms. Here we asked whether these results can be generalized to the planning and execution of immediate movements. To directly compare delayed, non-delayed, and suppressed reaching and grasping movements, we used a slow event-related functional magnetic resonance imaging (fMRI) design...
December 23, 2017: Cortex; a Journal Devoted to the Study of the Nervous System and Behavior
https://www.readbyqxmd.com/read/29332073/functional-anatomy-of-basal-ganglia-circuits-with-the-cerebral-cortex-and-the-cerebellum
#16
Andreea C Bostan, Richard P Dum, Peter L Strick
The neural connections of the basal ganglia provide important insights into their function. Here, we discuss the current perspective on basal ganglia connections with the cerebral cortex and with the cerebellum. We review the evidence that the basal ganglia participate in functionally segregated circuits with motor and non-motor areas of the cerebral cortex. We then discuss the data that the basal ganglia are interconnected with the cerebellum. These results provide the anatomical substrate for basal ganglia contributions not only to the control of movement, but also to a variety of cognitive and affective functions...
2018: Progress in Neurological Surgery
https://www.readbyqxmd.com/read/29332070/pathophysiologic-basis-of-movement-disorders
#17
Thomas Wichmann
Movement disorders are common and functionally disabling neurologic diseases. Studies over the last decades have investigated the pathophysiology of these diseases in considerable detail, leading to significant insights into their generation of motor disability. While genetically and clinically heterogeneous, most of them are accompanied by prominent and characteristic changes in firing rates and patterns in the basal ganglia, thalamus, and cortex. In recent years, researchers have placed increasing emphasis on the importance of oscillatory changes in firing in these structures, and have discovered that brain areas that were previously considered to be remote from the basal ganglia (such as the cerebellum and the pedunculopontine nucleus) are also highly significant in these disorders...
2018: Progress in Neurological Surgery
https://www.readbyqxmd.com/read/29331264/altered-levels-of-the-splicing-factor-muscleblind-modifies-cerebral-cortical-function-in-mouse-models-of-myotonic-dystrophy
#18
Gang Chen, Russell E Carter, John D Cleary, Tammy S Reid, Laura P Ranum, Maurice S Swanson, Timothy J Ebner
Myotonic dystrophy (DM) is a progressive, multisystem disorder affecting skeletal muscle, heart, and central nervous system. In both DM1 and DM2, microsatellite expansions of CUG and CCUG RNA repeats, respectively, accumulate and disrupt functions of alternative splicing factors, including muscleblind (MBNL) proteins. Grey matter loss and white matter changes, including the corpus callosum, likely underlie cognitive and executive function deficits in DM patients. However, little is known how cerebral cortical circuitry changes in DM...
January 10, 2018: Neurobiology of Disease
https://www.readbyqxmd.com/read/29330825/poststimulation-time-interval-dependent-effects-of-motor-cortex-anodal-tdcs-on-reaction-time-task-performance
#19
Andrés Molero-Chamizo, José R Alameda Bailén, Tamara Garrido Béjar, Macarena García López, Inmaculada Jaén Rodríguez, Carolina Gutiérrez Lérida, Silvia Pérez Panal, Gloria González Ángel, Laura Lemus Corchero, María J Ruiz Vega, Michael A Nitsche, Guadalupe N Rivera-Urbina
Anodal transcranial direct current stimulation (tDCS) induces long-term potentiation-like plasticity, which is associated with long-lasting effects on different cognitive, emotional, and motor performances. Specifically, tDCS applied over the motor cortex is considered to improve reaction time in simple and complex tasks. The timing of tDCS relative to task performance could determine the efficacy of tDCS to modulate performance. The aim of this study was to compare the effects of a single session of anodal tDCS (1...
January 12, 2018: Cognitive, Affective & Behavioral Neuroscience
https://www.readbyqxmd.com/read/29330684/investigation-of-mature-bdnf-and-probdnf-signaling-in-a-rat-photothrombotic-ischemic-model
#20
Mehreen Rahman, Haiyun Luo, Neil R Sims, Larisa Bobrovskaya, Xin-Fu Zhou
Treatment with mature brain-derived neurotrophic factor (mBDNF) promotes functional recovery after ischemia in animal trials but the possible role of its precursor protein proBDNF and its receptors or the factors responsible for the conversion of proBDNF to mBDNF in ischemic stroke are not known. The main aim of this study was to characterize the time-dependent expression of genes and/or proteins related to BDNF processing and signaling after ischemia as well as the sensorimotor behavioral dysfunction in a photothrombotic ischemic model in rats...
January 12, 2018: Neurochemical Research
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