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https://www.readbyqxmd.com/read/28738366/neuroanatomical-correlates-of-hypophonia-in-subcortical-vascular-cognitive-impairment
#1
Ji Hye Yoon, Yisuh Ahn, Sook Hui Kim, Juhee Chin, Seongbeom Park, Duk L Na
BACKGROUND/AIMS: Early detection and intervention may alter the disease course of subcortical vascular cognitive impairment (SVCI). Patients with SVCI have white matter ischemia that disrupts connections between the cortex and subcortical gray matter and therefore manifest various symptoms such as motor disturbances and behavioral/cognitive dysfunction. Reduced vocal loudness, or hypophonia, is one of the common motor symptoms of SVCI, but few studies have systematically investigated it in this patient population...
July 24, 2017: European Neurology
https://www.readbyqxmd.com/read/28737516/pre-therapy-neural-state-of-bilateral-motor-and-premotor-cortices-predicts-therapy-gain-after-subcortical-stroke-a-pilot-study
#2
Carmen M Cirstea, Phil Lee, Sorin C Craciunas, In-Young Choi, Joseph E Burris, Randolph J Nudo
OBJECTIVE: The aim of the study was to examine whether neural state of spared motor and premotor cortices captured before a therapy predicts therapy-related motor gains in chronic subcortical stroke. DESIGN: Ten survivors, presenting chronic moderate upper limb impairment, underwent proton magnetic resonance spectroscopy, magnetic resonance imaging, clinical, and kinematics assessments before a 4-wk impairment-oriented training. Clinical/kinematics assessments were repeated after therapy, and motor gain was defined as positive values of clinical upper limb/elbow motion changes and negative values of trunk motion changes...
July 22, 2017: American Journal of Physical Medicine & Rehabilitation
https://www.readbyqxmd.com/read/28736242/suppression-of-cortical-trpm7-protein-attenuates-oxidative-damage-after-traumatic-brain-injury-via-akt-endothelial-nitric-oxide-synthase-pathway
#3
Hong-Liang Xu, Meng-Dong Liu, Xiao-Hong Yuan, Chun-Xi Liu
Neuronal death after traumatic brain injury (TBI) is a complex process resulting from a combination of factors, many of which are still unknown. Transient receptor potential melastatin 7 (TRPM7) is a transient receptor potential channel that has been demonstrated to mediate ischemic and traumatic neuronal injury in vitro. In the present study, TRPM7 was suppressed in the rat cerebral cortex by intracortical injections of viral vectors bearing shRNA specific for TRPM7 to investigate its potential role in an in vivo TBI model...
July 20, 2017: Neurochemistry International
https://www.readbyqxmd.com/read/28735913/gray-matter-abnormalities-of-the-dorsal-posterior-cingulate-in-sleep-walking
#4
Anna Heidbreder, Ambra Stefani, Elisabeth Brandauer, Ruth Steiger, Christian Kremser, Elke R Gizewski, Peter Young, Werner Poewe, Birgit Högl, Christoph Scherfler
OBJECTIVE: This study aimed to determine whether voxel-based analysis of T1 weighted magnetic resonance imaging (MRI) and diffusion tensor imaging is able to detect alterations of gray and white matter morphometry as well as measures of mean diffusivity and fractional anisotropy in patients with non-rapid eye movement parasomnia. METHODS: 3 Tesla MRI was performed in 14 drug-free, polysomnography-confirmed adult patients with non-rapid eye movement parasomnia (age: 29 ± 4...
August 2017: Sleep Medicine
https://www.readbyqxmd.com/read/28735750/partially-mixed-selectivity-in-human-posterior-parietal-association-cortex
#5
Carey Y Zhang, Tyson Aflalo, Boris Revechkis, Emily R Rosario, Debra Ouellette, Nader Pouratian, Richard A Andersen
To clarify the organization of motor representations in posterior parietal cortex, we test how three motor variables (body side, body part, cognitive strategy) are coded in the human anterior intraparietal cortex. All tested movements were encoded, arguing against strict anatomical segregation of effectors. Single units coded for diverse conjunctions of variables, with different dimensions anatomically overlapping. Consistent with recent studies, neurons encoding body parts exhibited mixed selectivity. This mixed selectivity resulted in largely orthogonal coding of body parts, which "functionally segregate" the effector responses despite the high degree of anatomical overlap...
July 18, 2017: Neuron
https://www.readbyqxmd.com/read/28735748/behaviorally-selective-engagement-of-short-latency-effector-pathways-by-motor-cortex
#6
Andrew Miri, Claire L Warriner, Jeffrey S Seely, Gamaleldin F Elsayed, John P Cunningham, Mark M Churchland, Thomas M Jessell
Blocking motor cortical output with lesions or pharmacological inactivation has identified movements that require motor cortex. Yet, when and how motor cortex influences muscle activity during movement execution remains unresolved. We addressed this ambiguity using measurement and perturbation of motor cortical activity together with electromyography in mice during two forelimb movements that differ in their requirement for cortical involvement. Rapid optogenetic silencing and electrical stimulation indicated that short-latency pathways linking motor cortex with spinal motor neurons are selectively activated during one behavior...
July 19, 2017: Neuron
https://www.readbyqxmd.com/read/28735133/neurological-outcome-after-resection-of-parietal-lobe-including-primary-somatosensory-cortex-implications-of-additional-resection-of-posterior-parietal-cortex
#7
Young-Hoon Kim, June Sic Kim, Sang Kun Lee, Chun Kee Chung
OBJECTIVE: Postoperative neurological outcomes after primary somatosensory cortex (S1) resection have not been well-documented. This study was designed to evaluate the neurological deterioration that follows resection of the S1 areas and to assess the risk factors associated with these morbidities. METHODS: We reviewed 48 consecutive patients who suffered from medically intractable epilepsy and underwent resection of the S1 and/or the adjacent cortex. The 48 patients were categorized into 4 groups according to the resected area as seen on postoperative magnetic resonance images: Group 1 (resection of S1 only; n=4), 2 (the posterior parietal cortex (PPC) only; n=24), 3 (S1 and PPC; n=10), and 4 (S1 and precentral gyrus; n=10)...
July 19, 2017: World Neurosurgery
https://www.readbyqxmd.com/read/28735100/attention-modulates-specific-motor-cortical-circuits-recruited-by-transcranial-magnetic-stimulation
#8
J L Mirdamadi, L Y Suzuki, S K Meehan
Skilled performance and acquisition is dependent upon afferent input to motor cortex. The present study used short-latency afferent inhibition (SAI) to probe how manipulation of sensory afference by attention affects different circuits projecting to pyramidal tract neurons in motor cortex. SAI was assessed in the first dorsal interosseous muscle while participants performed a low or high attention demanding visual detection task. SAI was evoked by preceding a suprathreshold transcranial magnetic stimulus with electrical stimulation of the median nerve at the wrist...
July 19, 2017: Neuroscience
https://www.readbyqxmd.com/read/28733833/neuroanatomy-of-pain-deficiency-and-cross-modal-activation-in-calcium-channel-subunit-cacn-%C3%AE-2%C3%AE-3-knockout-mice
#9
Julia Landmann, Franziska Richter, Ana-Maria Oros-Peusquens, N Jon Shah, Joseph Classen, G Gregory Neely, Angelika Richter, Josef M Penninger, Ingo Bechmann
The phenotype of calcium channel subunit (CACN) α2δ3 knockout (KO) mice includes sensory cross-activation and deficient pain perception. Sensory cross-activation defines the activation of a sensory cortical region by input from another modality due to reorganization in the brain such as after sensory loss. To obtain mechanistic insight into both phenomena, we employed a comprehensive battery of neuroanatomical techniques. While CACNα2δ3 was ubiquitously expressed in wild-type mice, it was absent in α2δ3 KO animals...
July 21, 2017: Brain Structure & Function
https://www.readbyqxmd.com/read/28732063/dopamine-acting-at-d1-like-d2-like-and-%C3%AE-1-adrenergic-receptors-differentially-modulates-theta-and-gamma-oscillatory-activity-in-primary-motor-cortex
#10
Mazhar Özkan, Nicholas W Johnson, Umit S Sehirli, Gavin L Woodhall, Ian M Stanford
The loss of dopamine (DA) in Parkinson's is accompanied by the emergence of exaggerated theta and beta frequency neuronal oscillatory activity in the primary motor cortex (M1) and basal ganglia. DA replacement therapy or deep brain stimulation reduces the power of these oscillations and this is coincident with an improvement in motor performance implying a causal relationship. Here we provide in vitro evidence for the differential modulation of theta and gamma activity in M1 by DA acting at receptors exhibiting conventional and non-conventional DA pharmacology...
2017: PloS One
https://www.readbyqxmd.com/read/28730641/basal-ganglia-and-autism-a-translational-perspective
#11
REVIEW
Krishna Subramanian, Cheryl Brandenburg, Fernanda Orsati, Jean-Jacques Soghomonian, John P Hussman, Gene J Blatt
The basal ganglia are a collection of nuclei below the cortical surface that are involved in both motor and non-motor functions, including higher order cognition, social interactions, speech, and repetitive behaviors. Motor development milestones that are delayed in autism such as gross motor, fine motor and walking can aid in early diagnosis of autism. Neuropathology and neuroimaging findings in autism cases revealed volumetric changes and altered cell density in select basal ganglia nuclei. Interestingly, in autism, both the basal ganglia and the cerebellum are impacted both in their motor and non-motor domains and recently, found to be connected via the pons through a short disynaptic pathway...
July 21, 2017: Autism Research: Official Journal of the International Society for Autism Research
https://www.readbyqxmd.com/read/28730570/structural-connectivity-differences-in-essential-tremor-with-and-without-resting-tremor
#12
Maria Eugenia Caligiuri, Gennarina Arabia, Gaetano Barbagallo, Angela Lupo, Maurizio Morelli, Rita Nisticò, Fabiana Novellino, Andrea Quattrone, Maria Salsone, Basilio Vescio, Andrea Cherubini, Aldo Quattrone
In this work, we investigated motor network structure in patients affected by essential tremor (ET) with or without resting tremor, using probabilistic tractography of the cerebello-thalamo-basal ganglia-cortical loop. Twenty-five patients with ET, twenty-two patients with ET associated with resting tremor (rET), and twenty-five age- and sex-matched healthy controls were included in the study. All participants underwent whole-brain 3D T1-weighted and diffusion-weighted MRI, and DAT-SPECT. Probabilistic tractography was performed on diffusion data in network mode, reconstructing connections between the different structures of the cerebello-thalamo-basal ganglia-cortical loop...
July 20, 2017: Journal of Neurology
https://www.readbyqxmd.com/read/28730225/purkinje-cells-pathology-in-schizophrenia-a-morphometric-approach
#13
Ioannis Asterios Mavroudis, Foivos Petrides, Marina Manani, Fotios Chatzinikolaou, Alin Stelian Ciobică, Manuela Pădurariu, Dimitrios Kazis, Samuel Ndugu Njau, Vasiliki George Costa, Stavros John Baloyannis
OBJECTIVES: Schizophrenia is a brain disorder that affects more than 21 million people worldwide. Ventricle enlargement and reduction in the volume of the temporal lobe overall and in medial temporal structures constitutes the main macroscopic findings, whilst synaptic and spinal changes as well as gliosis in the hippocampal formation, the prefrontal and the entorhinal cortex stand among cardinal microscopic findings in the schizophrenic brains. In recent years, accumulated evidence comes to light about the role of cerebellum in the pathophysiology of schizophrenia...
2017: Romanian Journal of Morphology and Embryology, Revue Roumaine de Morphologie et Embryologie
https://www.readbyqxmd.com/read/28729936/are-there-differences-in-brain-morphology-according-to-handedness
#14
Han Jang, Jae Youn Lee, Kang Il Lee, Kang Min Park
OBJECTIVE: This study aimed to investigate the differences in brain morphology according to handedness. MATERIALS AND METHODS: Forty-two healthy subjects were enrolled (21 right-handers and 21 nonright-handers). The two groups were classified according to the Edinburgh Handedness Inventory. Measures of cortical morphology, such as thickness, surface area, volume, and curvature, and the volumes of subcortical structures, such as the amygdala, caudate, hippocampus, globus pallidus, putamen, and thalamus, were compared between the groups according to handedness using whole-brain 3D T1-weighted MRI...
July 2017: Brain and Behavior
https://www.readbyqxmd.com/read/28729830/resting-state-fluctuations-of-eeg-sensorimotor-rhythm-reflect-bold-activities-in-the-pericentral-areas-a-simultaneous-eeg-fmri-study
#15
Shohei Tsuchimoto, Shuka Shibusawa, Nobuaki Mizuguchi, Kenji Kato, Hiroki Ebata, Meigen Liu, Takashi Hanakawa, Junichi Ushiba
Blockade of the scalp electroencephalographic (EEG) sensorimotor rhythm (SMR) is a well-known phenomenon following attempted or executed motor functions. Such a frequency-specific power attenuation of the SMR occurs in the alpha and beta frequency bands and is spatially registered at primary somatosensory and motor cortices. Here, we hypothesized that resting-state fluctuations of the SMR in the alpha and beta frequency bands also covary with resting-state sensorimotor cortical activity, without involving task-related neural dynamics...
2017: Frontiers in Human Neuroscience
https://www.readbyqxmd.com/read/28729822/low-intensity-focused-tdcs-over-the-motor-cortex-shows-inefficacy-to-improve-motor-imagery-performance
#16
Irma N Angulo-Sherman, Marisol Rodríguez-Ugarte, Eduardo Iáñez, Jose M Azorín
Transcranial direct current stimulation (tDCS) is a brain stimulation technique that can enhance motor activity by stimulating the motor path. Thus, tDCS has the potential of improving the performance of brain-computer interfaces during motor neurorehabilitation. tDCS effects depend on several aspects, including the current density, which usually varies between 0.02 and 0.08 mA/cm(2), and the location of the stimulation electrodes. Hence, testing tDCS montages at several current levels would allow the selection of current parameters for improving stimulation outcomes and the comparison of montages...
2017: Frontiers in Neuroscience
https://www.readbyqxmd.com/read/28725924/effect-of-training-status-on-beta-range-corticomuscular-coherence-in-agonist-vs-antagonist-muscles-during-isometric-knee-contractions
#17
Fabien Dal Maso, Marieke Longcamp, Sylvain Cremoux, David Amarantini
Antagonist muscle co-activation is thought to be partially regulated by cortical influences, but direct motor cortex involvement is not fully understood. Corticomuscular coherence (CMC) measures direct functional coupling of the motor cortex and muscles. As antagonist co-activation differs according to training status, comparison of CMC in agonist and antagonist muscles and in strength-trained and endurance-trained individuals may provide in-depth knowledge of cortical implication in antagonist muscle co-activation...
July 19, 2017: Experimental Brain Research. Experimentelle Hirnforschung. Expérimentation Cérébrale
https://www.readbyqxmd.com/read/28723977/effect-of-inter-train-interval-on-the-induction-of-repetition-suppression-of-motor-evoked-potentials-using-transcranial-magnetic-stimulation
#18
Minna Pitkänen, Elisa Kallioniemi, Petro Julkunen
Repetition suppression (RS) is evident as a weakened response to repeated stimuli after the initial response. RS has been demonstrated in motor-evoked potentials (MEPs) induced with transcranial magnetic stimulation (TMS). Here, we investigated the effect of inter-train interval (ITI) on the induction of RS of MEPs with the attempt to optimize the investigative protocols. Trains of TMS pulses, targeted to the primary motor cortex by neuronavigation, were applied at a stimulation intensity of 120% of the resting motor threshold...
2017: PloS One
https://www.readbyqxmd.com/read/28722685/neural-control-of-finger-movement-via-intracortical-brain-machine-interface
#19
Zachary T Irwin, Karen E Schroeder, Philip P Vu, Autumn J Bullard, Derek M Tat, Chrono S Nu, Alex Vaskov, Samuel R Nason, David E Thompson, Nicole Bentley, Parag G Patil, Cynthia A Chestek
OBJECTIVE: Intracortical brain-machine interfaces (BMIs) are a promising source of prosthesis control signals for individuals with severe motor disabilities. Previous BMI studies have primarily focused on predicting and controlling whole-arm movements; precise control of hand kinematics, however, has not been fully demonstrated. Here, we investigate the continuous decoding of precise finger movements in rhesus macaques. APPROACH: In order to elicit precise and repeatable finger movements, we have developed a novel behavioral task paradigm which requires the subject to acquire virtual fingertip position targets...
July 19, 2017: Journal of Neural Engineering
https://www.readbyqxmd.com/read/28721533/minimum-norm-estimation-of-motor-representations-in-navigated-tms-mappings
#20
Minna Pitkänen, Elisa Kallioniemi, Petro Julkunen, Maria Nazarova, Jaakko O Nieminen, Risto J Ilmoniemi
Navigated transcranial magnetic stimulation (nTMS) can be applied to locate and outline cortical motor representations. This may be important, e.g., when planning neurosurgery or focused nTMS therapy, or when assessing plastic changes during neurorehabilitation. Conventionally, a cortical location is considered to belong to the motor cortex if the maximum electric field (E-field) targeted there evokes a motor-evoked potential in a muscle. However, the cortex is affected by a broad E-field distribution, which tends to broaden estimates of representation areas by stimulating also the neighboring areas in addition to the maximum E-field location...
July 18, 2017: Brain Topography
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