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https://www.readbyqxmd.com/read/29909591/update-on-the-use-of-c1-esterase-inhibitor-replacement-therapy-in-the-acute-and-prophylactic-treatment-of-hereditary-angioedema
#1
REVIEW
H Henry Li, Marc Riedl, Jay Kashkin
In the vast majority of patients with hereditary angioedema (HAE), angioedema attacks are due to the quantitative or functional deficiency of C1-esterase inhibitor (C1-INH), which leads to increased vascular permeability and unregulated release of bradykinin. Exogenous administration of C1-INH is a rational way to restore the concentration and functional activity of this protein, regulate the release of bradykinin, and attenuate or prevent subcutaneous and submucosal edema associated with HAE. Recent international guidelines for the management of HAE include C1-INH as an option for acute treatment of HAE...
June 16, 2018: Clinical Reviews in Allergy & Immunology
https://www.readbyqxmd.com/read/29908235/the-effect-of-antibiotics-on-social-aversion-following-early-life-inflammation
#2
Amanda C Kentner, Urma Khan, M MacRae, Scot E Dowd, Siyang Yan
Epidemiological evidence suggests that exposure to infection during early development increases the risk for neurodevelopmental disorders associated with symptoms such as a decreased desire to engage in social interactions. This disruption in social behavior can be modelled in animals by administering bacterial mimetics such as liposaccharide (LPS). However, when evaluating social interactions in the laboratory, attention is rarely directed on the reciprocal relationship as a whole, which is important as peers may drive social withdrawal...
June 13, 2018: Physiology & Behavior
https://www.readbyqxmd.com/read/29907635/increasing-rate-of-pulmonary-embolism-diagnosed-in-hospitalized-children-in-the-united-states-from-2001-to-2014
#3
Shannon L Carpenter, Troy Richardson, Matt Hall
Although rare in children, pulmonary embolism (PE) can cause significant morbidity and mortality. Overall rates of venous thromboembolism (VTE) are increasing in hospitalized children. By using the Pediatric Health Information System database, we evaluated incidence, treatment, and outcome of PE in children younger than age 18 years from 2001 to 2014. Demographic characteristics for those admitted with VTE alone and those admitted with PE were compared. Rates of PE by year were compared with the number of hospital and VTE admissions...
June 26, 2018: Blood Advances
https://www.readbyqxmd.com/read/29907335/trial-protocol-the-use-of-mindfulness-based-intervention-for-improving-bracing-compliance-for-adolescent-idiopathic-scoliosis-patients-protocol-for-a-randomised-controlled-trial
#4
Benjamin Hon Kei Yip, Xue Li, Christine Hiu Yan Leung, Ting Gao, Vincent Chi Ho Chung, Fiona Wai Ping Yu, Tsz Ping Lam, Jack Chun Yiu Cheng, Samuel Yeung Shan Wong
INTRODUCTION: Adolescent idiopathic scoliosis (AIS) is the most prevalent deforming orthopaedic condition; it causes significant disability when spinal curves progress beyond 45deg. Bracing is the primary treatment prescribed for adolescents with an immature skeleton who have spinal curves between 25 and 45deg. New evidence suggests that compliance with bracing significantly decreases the progression of high-risk curves to the threshold for surgery. Nonetheless, bracing is a stressful experience...
June 12, 2018: Journal of Physiotherapy
https://www.readbyqxmd.com/read/29905536/microrna-506-3p-inhibits-osteosarcoma-cell-proliferation-and-metastasis-by-suppressing-rab3d-expression
#5
Wang Jiashi, Qiu Chuang, Zhang Zhenjun, Wang Guangbin, Li Bin, He Ming
Osteosarcoma is an aggressive bone tumor primarily affecting children and adolescents. Its cause is not yet fully understood, and there is an urgent need for more effective treatment. In the present study we identified several miRNAs whose expression is altered in osteosarcoma compared to adjacent normal tissue. Moreover, expression levels of one of those miRNAs, miR-506-3p, correlated negatively with expression of RAB3D (a Ras-related protein). Suppression of miR-506-3p in osteosarcoma led to increased expression of RAB3D, which in turn led to increased CDK4 (cyclin-dependent kinase 4) and MMP9 (matrix metalloprotein 9) activities...
June 10, 2018: Aging
https://www.readbyqxmd.com/read/29905157/idiopathic-generalised-epilepsies-of-adult-onset-a-reappraisal-and-literature-review
#6
José Pimentel, Sara Varanda, Pedro Guimarães, Fernando Lopes da Silva
Idiopathic generalised epilepsies are characterised by widespread, symmetric, bilateral spike-and-wave discharges on EEG. Onset typically occurs in children and adolescents, but may also start in adulthood. These forms of adult onset constitute the focus of this review. A critical analysis of the medical literature was conducted through a narrative review search of PubMed and Medline databases. Cases of idiopathic generalised epilepsies with adult onset, in general, are not considered to be independent nosological entities...
June 15, 2018: Epileptic Disorders: International Epilepsy Journal with Videotape
https://www.readbyqxmd.com/read/29905044/-correlation-analysis-between-interleukin-6-polymorphism-and-adolescent-idiopathic-scoliosis-susceptibility-and-bracing-effectiveness
#7
Junsheng Gao, Lu Zhang, Zhiang Liu, Shuaihui Yao, Songming Gao
Objective: To analyze the correlation between the polymorphism on interleukin 6 (IL-6) gene promoter region-174 locus and adolescent idiopathic scoliosis (AIS), including the susceptibility, the bracing effectiveness, and the possible mechanism. Methods: The 182 AIS patients and 210 healthy controls who met the inclusion criteria between January 2013 and January 2016 were collected as research objects. The genotype of IL-6 gene promoter region-174 locus, the serum IL-6, the bone mineral density (BMD) of femoral neck and vertebrae (L 1-4 ), and the bone metabolism parameters, including bone alkaline phosphatase (BALP), bone gla protein (BGP), tartrate resistant acid phosphatase 5b (TRACP-5b), urine Ca, and urine Ca/Cr, were detected...
June 1, 2018: Chinese Journal of Reparative and Reconstructive Surgery
https://www.readbyqxmd.com/read/29904960/enhanced-dopamine-d2-autoreceptor-function-in-the-adult-prefrontal-cortex-contributes-to-dopamine-hypoactivity-following-adolescent-social-stress
#8
Matthew A Weber, Eric T Graack, Jamie L Scholl, Kenneth J Renner, Gina L Forster, Michael J Watt
Adult psychiatric disorders characterized by cognitive deficits reliant on prefrontal cortex (PFC) dopamine are promoted by teenage bullying. Similarly, male Sprague-Dawley rats exposed to social defeat in mid-adolescence (P35-39) show impaired working memory in adulthood (P56-70), along with decreased medial PFC (mPFC) dopamine activity that results in part from increased dopamine transporter-mediated clearance. Here, we determined if dopamine synthesis and D2 autoreceptor-mediated inhibition of dopamine release in the adult mPFC are also enhanced by adolescent defeat to contribute to later dopamine hypofunction...
June 14, 2018: European Journal of Neuroscience
https://www.readbyqxmd.com/read/29904907/systematic-review-and-guide-to-management-of-core-and-psychiatric-symptoms-in-youth-with-autism
#9
REVIEW
S H Ameis, C Kassee, P Corbett-Dick, L Cole, S Dadhwal, M-C Lai, J Veenstra-VanderWeele, C U Correll
OBJECTIVE: Evidence-based guidance of clinical decision-making for the management of Autism Spectrum Disorder (ASD) is lacking, particularly for co-occurring psychiatric symptoms. This review evaluates treatment evidence for six common symptom targets in children/adolescents with ASD and provides a resource to facilitate application of the evidence to clinical practice. METHOD: A systematic search identified randomized controlled trials (RCTs) and high-quality systematic reviews published between 2007 and 2016, focused on: social interaction/communication impairment, stereotypic/repetitive behaviours, irritability/agitation, attention-deficit/hyperactivity disorder symptoms, mood or anxiety symptoms, and sleep difficulties...
June 14, 2018: Acta Psychiatrica Scandinavica
https://www.readbyqxmd.com/read/29904898/relapsing-painful-ophthalmoplegic-neuropathy-no-longer-a-migraine-but-still-a-headache
#10
REVIEW
Stacy V Smith, Nathaniel M Schuster
PURPOSE OF REVIEW: Recurrent painful ophthalmoplegic neuropathy (RPON), formerly known as ophthalmoplegic migraine, is an uncommon disorder with repeated episodes of ocular cranial nerve neuropathy associated with ipsilateral headache. This review discusses the clinical presentation, current understanding of the pathophysiology, key differential diagnoses, and evaluation and treatment of RPON. RECENT FINDINGS: The literature is limited due to the rarity of the disorder...
June 14, 2018: Current Pain and Headache Reports
https://www.readbyqxmd.com/read/29904577/surgical-treatment-of-obesity
#11
REVIEW
Vance L Albaugh, Naji N Abumrad
Obesity prevalence continues to increase worldwide, as do the numerous chronic diseases associated with obesity, including diabetes, non-alcoholic fatty liver disease, dyslipidemia, and hypertension. The prevalence of bariatric surgery also continues to increase and remains the most effective and sustainable treatment for obesity. Over the last several years, numerous prospective and longitudinal studies have demonstrated the benefits of bariatric surgery on weight loss, mortality, and other chronic diseases...
2018: F1000Research
https://www.readbyqxmd.com/read/29903687/adolescents-experiences-of-obesity-surgery-a-qualitative-study
#12
Karin Nordin, Anna-Lena Brorsson, Kerstin Ekbom
BACKGROUND: The positive effects of behavioural treatment and weight management in adolescents with severe obesity are modest. Obesity surgery can be an option for adolescents, but is not the first-hand choice of treatment. The knowledge about adolescents' own experiences of having undergone surgery and their thoughts and feelings of the follow-up period are limited. OBJECTIVES: To describe adolescents' decision to go through obesity surgery as teenager and their experiences of the follow-up period...
April 26, 2018: Surgery for Obesity and related Diseases: Official Journal of the American Society for Bariatric Surgery
https://www.readbyqxmd.com/read/29903175/-prevalence-of-metabolic-syndrome-and-its-family-factors-for-children-and-adolescents-in-chongqing-city-in-2014
#13
Xuting Cheng, Hong Wang, Baocheng Yuan, Peiyu Guan, Lingyi Wang
OBJECTIVE: To study the prevalence and family factors on metabolic syndrome( MS) in children and adolescents for Chongqing City. METHODS: Multi-stage cluster sampling was used to recruit 1309 children and adolescents between 10 and 17 years old for physical examination( height, weight, waist circumference and blood pressure), blood biochemical examination( fasting plasma glucose, triglyceride, total cholesterol, high density lipoprotein cholesterol and low density lipoprotein cholesterol)and questionnaire for family factors( breast feeding, delivery mode, birth weight, education of parents, height and weight of parents, family history of hypertension and diabetes, and so on)...
July 2017: Wei Sheng Yan Jiu, Journal of Hygiene Research
https://www.readbyqxmd.com/read/29902964/australian-standards-of-care-and-treatment-guidelines-for-transgender-and-gender-diverse-children-and-adolescents
#14
Michelle M Telfer, Michelle A Tollit, Carmen C Pace, Ken C Pang
The Australian standards of care and treatment guidelines aim to maximise quality care provision to transgender and gender diverse (TGD) children and adolescents across Australia, while recognising the unique circumstances of providing such care to this population. Recommendations are made based on available empirical evidence and clinician consensus, and have been developed in consultation with Australian professionals from multiple disciplines working with the TGD population, TGD support organisations, as well as TGD children and adolescents and their families...
June 18, 2018: Medical Journal of Australia
https://www.readbyqxmd.com/read/29902929/group-procedures-for-decreasing-problem-behavior-displayed-by-detained-adolescents
#15
Cassidy B McDougale, Jodi C Coon, Sarah M Richling, Soracha O'Rourke, John T Rapp, Kelli R Thompson, Barry R Burkhart
As one component of providing treatment in a residential facility, Brogan, Falligant, and Rapp decreased problem behavior by two groups of detained adolescents using group contingency procedures. The current series of studies evaluated the extent to which group procedures could be extended to other contexts within a residential facility. In Study 1, fixed-time delivery of attention by dormitory staff decreased problem behavior displayed by a group of five to 11 detained adolescents during free periods. In Study 2, rules from a therapist plus contingencies for following those rules increased appropriate line walking during specific transition periods...
June 1, 2018: Behavior Modification
https://www.readbyqxmd.com/read/29902040/integrated-care-models-for-adhd-in-children-and-adolescents-a-systematic-review
#16
Jeffrey D Shahidullah, John S Carlson, Danielle Haggerty, Blake M Lancaster
INTRODUCTION: Attention-deficit/hyperactivity disorder (ADHD) in children and adolescents is commonly managed in primary care. Changes in United States health care have led to the integration of behavioral health services within a patient's "medical home" to improve access to, engagement in, and continuity of quality health care. Despite proliferation of these integrated care models, no studies have specifically examined models for managing ADHD in children and adolescents within primary care...
June 2018: Families, Systems & Health: the Journal of Collaborative Family Healthcare
https://www.readbyqxmd.com/read/29902035/family-based-youth-mental-health-interventions-delivered-by-nonspecialist-providers-in-low-and-middle-income-countries-a-systematic-review
#17
Elsa A Healy, Bonnie N Kaiser, Eve S Puffer
INTRODUCTION: Youth in low- and middle-income countries (LMICs) are at increased risk for poor mental health due to economic and social disadvantage. Interventions that strengthen families may equip children and adolescents with the supports and resources to fulfill their potential and buffer them from future stressors and adversity. Due to human resource constraints, task-sharing-delivery of interventions by nonspecialists-may be an effective strategy to facilitate the dissemination of mental health interventions in low resource contexts...
June 2018: Families, Systems & Health: the Journal of Collaborative Family Healthcare
https://www.readbyqxmd.com/read/29901174/cdc20-inhibitor-apcin-inhibits-the-growth-and-invasion-of-osteosarcoma-cells
#18
Yuan Gao, Benyuan Zhang, Yuming Wang, Guanning Shang
Osteosarcoma (OS) is the most common primary malignant bone tumor worldwide, primarily affecting children and adolescents. The anaphase promoting complex/cyclosome (APC/C) is a ubiquitin ligase that is activated by its co‑activator Cdc20 during the metaphase‑anaphase transition. Apcin is a novel cell‑permeable molecule that blocks the interaction between APC/C and Cdc20. Cdc20 overexpression has been reported in various malignancies and plays an oncogenic role in tumorigenesis and tumor progression. In the present study, the antitumor properties of apcin, an inhibitor of Cdc20, was investigated in OS cell lines...
May 30, 2018: Oncology Reports
https://www.readbyqxmd.com/read/29900751/the-effect-of-clown-intervention-on-self-report-and-biomarker-measures-of-stress-and-fatigue-in-pediatric-osteosarcoma-inpatients-a-pilot-study
#19
Luis C Lopes-Júnior, Gabriela Pereira-da-Silva, Denise S C Silveira, Luciana C Veronez, Jéssica C Santos, Jonas B Alonso, Regina A G Lima
BACKGROUND: Pediatric cancer patients experience different psychological processes during hospitalization that may regulate the immune response and affect recovery and response to cancer treatment. In this study, we aimed to examine the feasibility of longitudinal testing of psychophysiological parameters of stress and fatigue in pediatric osteosarcoma patients hospitalized for chemotherapy submitted to clown intervention; and to investigate whether changes in the levels of biomarkers are associated with psychological stress and fatigue levels in these patients after the clown intervention...
June 1, 2018: Integrative Cancer Therapies
https://www.readbyqxmd.com/read/29900616/the-role-of-acceptance-of-violence-beliefs-and-social-information-processing-on-dating-violence-perpetration
#20
Liria Fernández-González, Esther Calvete, Izaskun Orue
This study's main objective was to explore whether beliefs legitimizing dating violence predict dysfunctional social information processing (SIP) when adolescents deal with ambiguous dating situations, and whether this more proximal cognitive processing acts as a mediator between acceptance of violence beliefs and dating violence perpetration. Participants were 855 high school students who completed self-report measures at three time points, with a 1-year interval between them. SIP did not act as a mediator, but the emergence of anger emotions in dating conflict situations, along with aggression-justifying beliefs, were revealed as essential in explaining dating violence...
June 13, 2018: Journal of Research on Adolescence: the Official Journal of the Society for Research on Adolescence
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