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https://www.readbyqxmd.com/read/28655195/positive-autobiographical-memory-retrieval-reduces-temporal-discounting
#1
Karolina M Lempert, Megan E Speer, Mauricio R Delgado, Elizabeth A Phelps
People generally prefer rewards sooner rather than later. This phenomenon, temporal discounting, underlies many societal problems, including addiction and obesity. One way to reduce temporal discounting is to imagine positive future experiences. Since there is overlap in the neural circuitry associated with imagining future experiences and remembering past events, here we investigate whether recalling positive memories can also promote more patient choice. We found that participants were more patient after retrieving positive autobiographical memories, but not when they recalled negative memories...
June 26, 2017: Social Cognitive and Affective Neuroscience
https://www.readbyqxmd.com/read/28655157/neuroinflammation-and-tau-interact-with-amyloid-in-predicting-sleep-problems-in-aging-independently-of-atrophy
#2
Anders Martin Fjell, Ane-Victoria Idland, Roser Sala-Llonch, Leiv Otto Watne, Tom Borza, Anne Brækhus, Tarjei Lona, Henrik Zetterberg, Kaj Blennow, Torgeir Bruun Wyller, Kristine Beate Walhovd
Sleep problems relate to brain changes in aging and disease, but the mechanisms are unknown. Studies suggest a relationship between β-amyloid (Aβ) accumulation and sleep, which is likely augmented by interactions with multiple variables. Here, we tested how different cerebrospinal fluid (CSF) biomarkers for brain pathophysiology, brain atrophy, memory function, and depressive symptoms predicted self-reported sleep patterns in 91 cognitively healthy older adults over a 3-year period. The results showed that CSF levels of total- and phosphorylated (P) tau, and YKL-40-a marker of neuroinflammation/astroglial activation-predicted poor sleep in Aβ positive older adults...
June 26, 2017: Cerebral Cortex
https://www.readbyqxmd.com/read/28655152/faulty-adaptation-to-repeated-face-name-associative-pairs-in-mild-cognitive-impairment-is-predictive-of-cognitive-decline
#3
Sarah M Jurick, Gali H Weissberger, Lindsay R Clark, Christina E Wierenga, Yu-Ling Chang, Dawn M Schiehser, S Duke Han, Amy J Jak, Sheena I Dev, Mark W Bondi
Objective: We examined BOLD (Blood-Oxygen-Level Dependent) activity reduction upon stimuli repetition of face-name pairs in older adults with amnestic (aMCI) and non-amnestic (naMCI) mild cognitive impairment diagnosed using a comprehensive actuarial method, and relationships between activity reduction and behavioral indices. Method: Twenty-nine cognitively healthy older adults (CHs) and 20 with MCI (n = 12 aMCI; n = 8 naMCI) underwent functional MRI event-related imaging, a comprehensive neuropsychological battery, and 1-year follow-up exam...
June 26, 2017: Archives of Clinical Neuropsychology: the Official Journal of the National Academy of Neuropsychologists
https://www.readbyqxmd.com/read/28655042/a-novel-investigation-of-generalized-motor-program-theory-syllable-stress-as-a-motor-class-variable
#4
Kimberly M Meigh
Purpose: This experiment evaluated syllable-stress position as a motor class directed by a syllable-sized generalized motor program. Reaction times were predicted to be slower for stimuli with untrained stress patterns outside the trained motor class. Furthermore, reaction times were predicted to be stable for untrained stimuli within the same motor class regardless of phonetic similarity. Method: Twenty-three young adults with typical speech and hearing participated in a motor-learning study comprised of motor-class training and a judgment task...
June 22, 2017: Journal of Speech, Language, and Hearing Research: JSLHR
https://www.readbyqxmd.com/read/28654960/the-cost-of-making-an-eye-movement-a-direct-link-between-visual-working-memory-and-saccade-execution
#5
Martijn J Schut, Nathan Van der Stoep, Albert Postma, Stefan Van der Stigchel
To facilitate visual continuity across eye movements, the visual system must presaccadically acquire information about the future foveal image. Previous studies have indicated that visual working memory (VWM) affects saccade execution. However, the reverse relation, the effect of saccade execution on VWM load is less clear. To investigate the causal link between saccade execution and VWM, we combined a VWM task and a saccade task. Participants were instructed to remember one, two, or three shapes and performed either a No Saccade-, a Single Saccade- or a Dual (corrective) Saccade-task...
June 1, 2017: Journal of Vision
https://www.readbyqxmd.com/read/28654848/gender-differences-in-the-association-between-physical-activity-and-cognitive-function-in-individuals-with-bipolar-disorder
#6
F T Fellendorf, N Kainzbauer, M Platzer, N Dalkner, S A Bengesser, A Birner, R Queissner, P Rauch, C Hamm, R Pilz, E Z Reininghaus
INTRODUCTION: Bipolar disorder (BD) is accompanied by a high number of comorbidities and associated with an overall increased mortality. Especially obesity, systemic inflammatory processes and cognitive deficits are highly prevalent and increase with the course of illness. Physical activity (PA) is associated with beneficial effects on somatic comorbidities such as obesity or cardiovascular disease in individuals without psychiatric disorder. Furthermore, PA might increase neurocognitive performance and reduce systemic inflammation...
June 21, 2017: Journal of Affective Disorders
https://www.readbyqxmd.com/read/28654817/the-role-of-the-hippocampus-in-recognition-memory
#7
REVIEW
Chris M Bird
Many theories of declarative memory propose that it is supported by partially separable processes underpinned by different brain structures. The hippocampus plays a critical role in binding together item and contextual information together and processing the relationships between individual items. By contrast, the processing of individual items and their later recognition can be supported by extrahippocampal regions of the medial temporal lobes (MTL), particularly when recognition is based on feelings of familiarity without the retrieval of any associated information...
June 1, 2017: Cortex; a Journal Devoted to the Study of the Nervous System and Behavior
https://www.readbyqxmd.com/read/28654799/neurobehavioral-consequences-of-continuous-spike-and-waves-during-slow-sleep-csws-in-a-pediatric-population-a-pattern-of-developmental-hindrance
#8
Valentina De Giorgis, Melissa Filippini, Joyce Ann Macasaet, Silvia Masnada, Pierangelo Veggiotti
INTRODUCTION: Continuous spike and waves during slow sleep (CSWS) is a typical EEG pattern defined as diffuse, bilateral and recently also unilateral or focal localization spike-wave occurring in slow sleep or non-rapid eye movement sleep. Literature results so far point out a progressive deterioration and decline of intellectual functioning in CSWS patients, i.e. a loss of previously normally acquired skills, as well as persistent neurobehavioral disorders, beyond seizure and EEG control...
June 24, 2017: Epilepsy & Behavior: E&B
https://www.readbyqxmd.com/read/28654773/increased-anxiety-and-fear-memory-in-adult-mice-lacking-type-2-deiodinase
#9
Soledad Bárez-López, Ana Montero-Pedrazuela, Daniel Bosch-García, César Venero, Ana Guadaño-Ferraz
A euthyroid state in the brain is crucial for its adequate development and function. Impairments in thyroid hormones (THs; T3 or 3,5,3'-triiodothyronine and T4 or thyroxine) levels and availability in brain can lead to neurological alterations and to psychiatric disorders, particularly mood disorders. The thyroid gland synthetizes mainly T4, which is secreted to circulating blood, however, most actions of THs are mediated by T3, the transcriptionally active form. In the brain, intracellular concentrations of T3 are modulated by the activity of type 2 (D2) and type 3 (D3) deiodinases...
June 16, 2017: Psychoneuroendocrinology
https://www.readbyqxmd.com/read/28654756/hydrogels-with-a-memory-dual-responsive-organometallic-poly-ionic-liquid-s-with-hysteretic-volume-phase-transition
#10
Kaihuan Zhang, Xueling Feng, Chongnan Ye, Mark A Hempenius, G Julius Vancso
We report on the synthesis and structure property relations of a novel, dual-responsive organometallic poly(ionic liquid) (PIL), consisting of a poly(ferrocenylsilane) backbone of alternating redox-active, silane bridged ferrocene units, and tetraalkylphosphonium sulfonate moieties in the side groups. This PIL is redox responsive due to the presence of ferrocene in the backbone, and also exhibits a lower critical solution temperature (LCST)-type thermal responsive behaviour. The LCST phase transition originates from the interaction between water molecules and the ionic substituents and shows a concentration-dependent, tunable transition temperature in aqueous solution...
June 27, 2017: Journal of the American Chemical Society
https://www.readbyqxmd.com/read/28654697/correction-a-physically-modified-saline-suppresses-neuronal-apoptosis-attenuates-tau-phosphorylation-and-protects-memory-in-an-animal-model-of-alzheimer-s-disease
#11
Khushbu K Modi, Arundhati Jana, Supurna Ghosh, Richard Watson, Kalipada Pahan
[This corrects the article DOI: 10.1371/journal.pone.0103606.].
2017: PloS One
https://www.readbyqxmd.com/read/28654687/combined-single-cell-quantitation-of-host-and-siv-genes-and-proteins-ex-vivo-reveals-host-pathogen-interactions-in-individual-cells
#12
Diane L Bolton, Kathleen McGinnis, Greg Finak, Pratip Chattopadhyay, Raphael Gottardo, Mario Roederer
CD4 T cells harboring HIV-1/SIV represent a formidable hurdle to eradicating infection, and yet their detailed phenotype remains unknown. Here we integrate two single-cell technologies, flow cytometry and highly multiplexed quantitative RT-PCR, to characterize SIV-infected CD4 T cells directly ex vivo. Within individual cells, we correlate the cellular phenotype, in terms of host protein and RNA expression, with stages of the viral life cycle defined by combinatorial expression of viral RNAs. Spliced RNA+ infected cells display multiple memory and activation phenotypes, indicating virus production by diverse CD4 T cell subsets...
June 27, 2017: PLoS Pathogens
https://www.readbyqxmd.com/read/28654656/developmental-trajectory-of-the-corpus-callosum-from-infancy-to-the-juvenile-stage-comparative-mri-between-chimpanzees-and-humans
#13
Tomoko Sakai, Akichika Mikami, Juri Suzuki, Takako Miyabe-Nishiwaki, Mie Matsui, Masaki Tomonaga, Yuzuru Hamada, Tetsuro Matsuzawa, Hideyuki Okano, Kenichi Oishi
How brains develop during early life is one of the most important topics in neuroscience because it underpins the neuronal functions that mature during this period. A comparison of the neurodevelopmental patterns among humans and nonhuman primates is essential to infer evolutional changes in neuroanatomy that account for higher-order brain functions, especially those specific to humans. The corpus callosum (CC) is the major white matter bundle that connects the cerebral hemispheres, and therefore, relates to a wide variety of neuronal functions...
2017: PloS One
https://www.readbyqxmd.com/read/28654460/liposomal-cytarabine-induces-less-neurocognitive-dysfunction-than-intrathecal-methotrexate-in-an-animal-model
#14
Anna M Thomsen, Maria E Gulinello, Jing Wen, Kjeld Schmiegelow, Peter D Cole
Liposomal cytarabine is currently being tested clinically as an alternative to intrathecal (IT) methotrexate (MTX) for preventing relapse within the central nervous system among patients with acute lymphoblastic leukemia. To compare the toxicity and cognitive deficits caused by IT MTX versus liposomal cytarabine, juvenile Long Evans rats were treated with IT injections of MTX 1 mg/kg×4 doses over 8 days, or liposomal cytarabine 0.8 mg once. Mean concentrations of free cytarabine in cerebrospinal fluid remained above the cytotoxic threshold of 0...
June 26, 2017: Journal of Pediatric Hematology/oncology
https://www.readbyqxmd.com/read/28654361/enhancing-spatial-attention-and-working-memory-in-younger-and-older-adults
#15
Camarin E Rolle, Joaquin A Anguera, Sasha N Skinner, Bradley Voytek, Adam Gazzaley
Daily experiences demand both focused and broad allocation of attention for us to interact efficiently with our complex environments. Many types of attention have shown age-related decline, although there is also evidence that such deficits may be remediated with cognitive training. However, spatial attention abilities have shown inconsistent age-related differences, and the extent of potential enhancement of these abilities remains unknown. Here, we assessed spatial attention in both healthy younger and older adults and trained this ability in both age groups for 5 hr over the course of 2 weeks using a custom-made, computerized mobile training application...
June 27, 2017: Journal of Cognitive Neuroscience
https://www.readbyqxmd.com/read/28654221/high-salt-diet-impairs-memory-related-synaptic-plasticity-via-increased-oxidative-stress-and-suppressed-synaptic-protein-expression
#16
Qian Ge, Zhengjun Wang, Yuwei Wu, Qing Huo, Zhaoqiang Qian, Zhongmin Tian, Wei Ren, Xia Zhang, Jing Han
SCOPE: A high salt (HS) diet is detrimental to cognitive function, in addition to having a role in cardiovascular disorders. However, the method by which a HS diet impairs cognitive functions such as learning and memory remains open. METHODS AND RESULTS: In this study, we found that mice on a 7 week HS diet demonstrated disturbed short-term memory in an object-place recognition task, and both 4 week and 7 week HS treatments impaired long-term memory, as evidenced in a fear conditioning test...
June 27, 2017: Molecular Nutrition & Food Research
https://www.readbyqxmd.com/read/28654074/a-chronic-autoimmune-dry-eye-rat-model-with-increase-in-effector-memory-t-cells-in-eyeball-tissue
#17
Aihua Hou, Tanima Bose, K George Chandy, Louis Tong
Dry eye disease is a very common condition that causes morbidity and healthcare burden and decreases the quality of life. There is a need for a suitable dry eye animal model to test novel therapeutics to treat autoimmune dry eye conditions. This protocol describes a chronic autoimmune dry eye rat model. Lewis rats were immunized with an emulsion containing lacrimal gland extract, ovalbumin, and complete Freund's adjuvant. A second immunization with the same antigens in incomplete Freund's adjuvant was administered two weeks later...
June 7, 2017: Journal of Visualized Experiments: JoVE
https://www.readbyqxmd.com/read/28654032/assessing-working-memory-in-children-the-comprehensive-assessment-battery-for-children-working-memory-cabc-wm
#18
Kathryn Cabbage, Shara Brinkley, Shelley Gray, Mary Alt, Nelson Cowan, Samuel Green, Trudy Kuo, Tiffany P Hogan
The Comprehensive Assessment Battery for Children - Working Memory (CABC-WM) is a computer-based battery designed to assess different components of working memory in young school-age children. Working memory deficits have been identified in children with language-based learning disabilities, including dyslexia(1)(,)(2) and language impairment(3)(,)(4), but it is not clear whether these children exhibit deficits in subcomponents of working memory, such as visuospatial or phonological working memory. The CABC-WM is administered on a desktop computer with a touchscreen interface and was specifically developed to be engaging and motivating for children...
June 12, 2017: Journal of Visualized Experiments: JoVE
https://www.readbyqxmd.com/read/28653951/answer-to-photo-quiz-a-gap-in-memory-tape
#19
(no author information available yet)
No abstract text is available yet for this article.
June 2017: Netherlands Journal of Medicine
https://www.readbyqxmd.com/read/28653950/a-gap-in-memory-tape
#20
M Saeed, P J Menon, M Elkider, T M Abkur
No abstract text is available yet for this article.
June 2017: Netherlands Journal of Medicine
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