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https://www.readbyqxmd.com/read/28532137/the-comparative-study-of-ondansetron-and-metoclopramide-effects-in-reducing-nausea-and-vomiting-after-laparoscopic-cholecystectomy
#1
Khatereh Isazadehfar, Masoud Entezariasl, Bita Shahbazzadegan, Zahra Nourani, Yousef Shafaee
Postoperative nausea and vomiting (PONV) are one of the most common complications of anesthesia and without prophylactic intervention occurs by about one-third of patients under general anesthesia. The aim of this study was to compare the efficacy of ondansetron and metoclopramide in reducing PONV after laparoscopic cholecystectomy. In this study, 60 patients undergoing laparoscopic cholecystectomy were randomly allocated into two equal groups (n=30), and in the first group 10 mg metoclopramide and in the second group 4 mg ondansetron preoperatively were injected...
April 2017: Acta Medica Iranica
https://www.readbyqxmd.com/read/28526687/ffa2-activation-combined-with-ulcerogenic-cox-inhibition-induces-duodenal-mucosal-injury-via-the-5-ht-pathway-in-rats
#2
Yasutada Akiba, Koji Maruta, Kazuyuki Narimatsu, Hyder Said, Izumi Kaji, Ayaka Kuri, Ken-Ichi Iwamoto, Atsukazu Kuwahara, Jonathan D Kaunitz
Serotonin (5-HT), predominantly synthesized and released by enterochromaffin cells, is implicated in gastrointestinal symptoms such as emesis, abdominal pain and diarrhea. Since luminal short-chain fatty acids (SCFAs) release 5-HT from enterochromaffin cells, which express the SCFA receptor FFA2 in rat duodenum, we examined the effects of the selective FFA2 agonist phenylacetamide-1 (PA1) on duodenal 5-HT release with consequent bicarbonate secretion (DBS) and on indomethacin (IND)-induced enteropathy. Intestinal injury was induced by IND (10 mg/kg, sc) with or without PA1...
May 19, 2017: American Journal of Physiology. Gastrointestinal and Liver Physiology
https://www.readbyqxmd.com/read/28514235/ondansetron-does-not-reduce-withdrawal-in-patients-with-physical-dependence-on-chronic-opioid-therapy
#3
Larry F Chu, John Sun, Anna Clemenson, Matthew J Erlendson, Tom Rico, Erika Cornell, Hannah Obasi, Zahra N Sayyid, Ellen M Encisco, Jeff Yu, Jamison G Gamble, Ian Carroll, J David Clark
OBJECTIVES: Individuals taking opioids for an extended period of time may become physically dependent, and will therefore experience opioid withdrawal should they stop taking the medication. Previous work in animal and human models has shown that the serotonin (5-HT3) receptor may be implicated in opioid withdrawal. In this study, we investigated if ondansetron, a 5-HT3-receptor antagonist, could reduce the symptoms of opioid withdrawal after chronic opioid exposure in humans. METHODS: In this double-blinded, randomized, crossover study, 33 chronic back pain patients (N = 33) were titrated onto sustained-release oral morphine for 30 days...
May 16, 2017: Journal of Addiction Medicine
https://www.readbyqxmd.com/read/28505233/addition-of-droperidol-to-prophylactic-ondansetron-and-dexamethasone-in-children-at-high-risk-for-postoperative-vomiting-a-randomized-controlled-double-blind-study
#4
N Bourdaud, C François, O Jacqmarcq, M-L Guye, J Jean, C Studer, C Engrand-Donal, J-M Devys, F Boutin, E Guyot, N Bouazza, J-M Treluyer, G A Orliaguet
Background: : The combination of dexamethasone (DEX), ondansetron (OND) and droperidol (DRO) is efficacious in preventing postoperative nausea and vomiting in adults, but has not been well assessed in children. Methods: : Children undergoing elective surgery under general anaesthesia and considered at high risk for postoperative vomiting (POV) were randomly assigned to receive a combination of DEX, OND and placebo (Group A) or a combination of DEX, OND and DRO (Group B)...
May 15, 2017: British Journal of Anaesthesia
https://www.readbyqxmd.com/read/28500978/novel-polyglycerol-dioleate-based-cubosomal-dispersion-with-tailored-physical-characteristics-for-controlled-delivery-of-ondansetron
#5
M Mansour, A O Kamel, S Mansour, N D Mortada
In this study different amphiphilic lipids viz. glycerylmonooleate (GMO), Glycerylmonolinoleate (GML), Plurol(®) (polyglycerol 3-dioleate), Soya phosphatidylcholine (Soya PC), Dipalmitoyl-phosphatidylcholine (DPPC) and Dipalmitoyl- phosphatidylglycerol (DPPG) were screened for their ability to form cubosomes and the formed particles were optimized for controlled delivery using ondansetron as a model drug. Polarized optical microscopy and high resolution transmission electron microscopy were performed to investigate the morphology of the prepared particles...
April 26, 2017: Colloids and Surfaces. B, Biointerfaces
https://www.readbyqxmd.com/read/28500750/nausea-and-vomiting-in-children-and-adolescents-receiving-intrathecal-methotrexate-a-prospective-observational-study
#6
Jacqueline Flank, Komail Nadeem, Sheliza Moledina, Mila Khanna, Christina Schindera, Angela Punnett, L Lee Dupuis
BACKGROUND: The prevalence of nausea and vomiting after receipt of intrathecal methotrexate (IT-MTX) in pediatric oncology patients is unknown. METHODS: Patients (4-18 years) about to receive IT-MTX were eligible to participate in this prospective, observational study. Patients received antiemetics as prescribed by their clinical team. Nausea severity (patient-assessed), timing of emetic episodes, and administration of antiemetics were recorded beginning immediately prior to IT-MTX administration, for the next 24 hr (acute phase), and for a maximum of 7 additional days (delayed phase)...
May 13, 2017: Pediatric Blood & Cancer
https://www.readbyqxmd.com/read/28493078/the-5-ht3-receptor-antagonist-ondansetron-attenuates-pancreatic-injury-in-cerulein-induced-acute-pancreatitis-model
#7
Atsushi Tsukamoto, Takuto Sugimoto, Yuta Onuki, Hajime Shinoda, Taiki Mihara, Masatoshi Hori, Tomo Inomata
The 5-hydroxytryptamine-3 receptor (5-HT3R) antagonist ondansetron has been clinically approved as an anti-emetic agent. Recent findings indicate that ondansetron has anti-inflammatory properties. The aim of the present study was to assess the therapeutic action of ondansetron in cerulein-induced acute pancreatitis model. Male-BALB/c mice were used in the present study. Acute pancreatitis was induced by an hourly injection of cerulein. Ondansetron was administered subcutaneously at a dose of 3 mg/kg. The messenger RNA (mRNA) expression of 5-HT3 R in pancreatic tissue was assessed with RT-PCR...
May 10, 2017: Inflammation
https://www.readbyqxmd.com/read/28484658/thermal-esophageal-injury-following-ingestion-of-boiling-mushroom-water
#8
Allison Prevost, Adam Talley, Emily Klepper, Elizabeth McDonough
Thermal esophageal and gastric damage from ingestion of hot liquids is poorly studied in pediatrics. Limited case reports exist in the literature. Many cases presented with chest pain, dysphagia, and odynophagia. Variable histologic findings were reported. No definitive management guidelines exist for such injuries. We provide a report of the acute assessment and management of an obvious thermal esophageal injury and contribute to what is known about this presentation. A 16-year-old male presented with odynophagia, dysphagia, and hematemesis following ingestion of "nearly boiling" mushroom water...
2017: Case Reports in Pediatrics
https://www.readbyqxmd.com/read/28464238/ondansetron-for-neuraxial-morphine-induced-pruritus-a-meta-analysis-of-randomized-controlled-trials
#9
REVIEW
W Wang, L Zhou, L Sun
WHAT IS KNOWN AND OBJECTIVE: Pruritus is one of the most common adverse effects associated with neuraxial morphine. Ondansetron has been used to deal with the problem of neuraxial morphine-induced pruritus (NMIP). The aim of this meta-analysis was to evaluate the preventive efficacy of ondansetron on NMIP. METHODS: Online databases such as PubMed, EMBASE and the Cochrane Central Register of Controlled Trials were searched for eligible randomized controlled trials (RCTs)...
May 2, 2017: Journal of Clinical Pharmacy and Therapeutics
https://www.readbyqxmd.com/read/28449280/a-randomised-controlled-trial-of-placebo-droperidol-or-ondansetron-to-prevent-nausea-and-vomiting-after-tonsillectomy-in-children-receiving-dexamethasone
#10
P Flubacher, N Fournier, J Cherpillod, F Waridel, M Nydegger, E Albrecht
We tested whether prophylactic droperidol and ondansetron, in combination with a moderate dose of dexamethasone, were equally effective in reducing nausea and vomiting after tonsillectomy in children and that both were superior to saline with dexamethasone. We randomly allocated 300 children to intravenous saline, droperidol 10 μg.kg(-1) or ondansetron 150 μg.kg(-1) , after induction of anaesthesia and the administration of intravenous dexamethasone 250 μg.kg(-1) . The rates (95%CI) of nausea or vomiting within 24 postoperative hours were: 42/91 after saline, 46% (36%-57%); 43/87 after droperidol, 49% (39%-60%); reduced to 18/84 by ondansetron, 21% (13%-32%), p < 0...
April 27, 2017: Anaesthesia
https://www.readbyqxmd.com/read/28414050/a-study-of-time-and-sex-dependent-effects-of-vortioxetine-on-rat-sexual-behavior-possible-roles-of-direct-receptor-modulation
#11
Yan Li, Alan L Pehrson, Ronald S Oosting, Maria Gulinello, Berend Olivier, Connie Sanchez
Treatment-related sexual dysfunction is a common side effect of antidepressants and contributes to patient non-compliance or treatment cessation. However, the multimodal antidepressant, vortioxetine, demonstrates low sexual side effects in depressed patients. To investigate the mechanisms involved, sexual behavior was assessed in male and female rats after acute, and repeated (7 and 14 days) treatment with vortioxetine, flesinoxan (a 5-HT1A receptor agonist), CP-94253 (a 5-HT1B receptor agonist), or ondansetron (a 5-HT3 receptor antagonist)...
April 13, 2017: Neuropharmacology
https://www.readbyqxmd.com/read/28408644/human-derived-gut-microbiota-modulates-colonic-secretion-in-mice-by-regulating-5-ht3-receptor-expression-via-acetate-production
#12
Yogesh Bhattarai, Bradley A Schmidt, David R Linden, Eric D Larson, Madhusudan Grover, Arthur Beyder, Gianrico Farrugia, Purna C Kashyap
Serotonin (5-hydroxytryptamine, 5-HT), an important neurotransmitter and a paracrine messenger in the gastrointestinal (GI) tract, regulates intestinal secretion by its action primarily on 5-HT3 and 5-HT4 receptors. Recent studies highlight the role of gut microbiota in 5-HT biosynthesis. In this study we determine if human-derived gut microbiota affect host secretory response to 5-HT and 5-HT receptor expression. We used proximal colonic mucosa-submucosa preparation from age matched Swiss Webster germ free (GF) and humanized (HM; ex-GF colonized with human gut microbiota) mice...
April 13, 2017: American Journal of Physiology. Gastrointestinal and Liver Physiology
https://www.readbyqxmd.com/read/28384832/obsessive-compulsive-disorder-advances-in-diagnosis-and-treatment
#13
Matthew E Hirschtritt, Michael H Bloch, Carol A Mathews
Importance: Obsessive-compulsive disorder (OCD) is a neuropsychiatric disorder associated with significant impairment and a lifetime prevalence of 1% to 3%; however, it is often missed in primary care settings and frequently undertreated. Objective: To review the most current data regarding screening, diagnosis, and treatment options for OCD. Evidence Review: We searched PubMed, EMBASE, and PsycINFO to identify randomized controlled trials (RCTs), meta-analyses, and systematic reviews that addressed screening and diagnostic and treatment approaches for OCD among adults (≥18 years), published between January 1, 2011, and September 30, 2016...
April 4, 2017: JAMA: the Journal of the American Medical Association
https://www.readbyqxmd.com/read/28383360/is-ondansetron-augmentation-effective-in-obsessive-compulsive-disorder
#14
Bangalore G Kalyani, Aditya Hegde, Shyam Sundar Arumugham, Janardhanan C Narayanaswamy, Suresh Bada Math, Y C Janardhan Reddy
No abstract text is available yet for this article.
June 2017: Journal of Clinical Psychopharmacology
https://www.readbyqxmd.com/read/28372658/a-case-of-paradoxical-presentation-of-a-postural-postdural-puncture-headache-after-combined-spinal-epidural-anesthesia
#15
John W Bordlee, Burton D Beakley, Rayomond Mody, Anne P McConville, Jonathan T Weed, Brian P McClure, Peter J Foldes, Jonathan G Ma, Alan D Kaye, Jonathan P Eskander
We report a case of paradoxical presentation of a postural postdural puncture headache secondary to dural puncture with a 25-gauge Whitacre needle for combined spinal-epidural anesthesia. This 27-year-old female patient presented to the emergency department with elevated blood pressure and a global headache 9 days after administration of epidural anesthesia for a spontaneous vaginal delivery after an uncomplicated pregnancy. The patient reported that the headache was more intense when lying down and immediately improved when she sat or stood up from a recumbent position...
May 2017: Journal of Clinical Anesthesia
https://www.readbyqxmd.com/read/28370228/pharmacologic-treatment-of-cannabinoid-hyperemesis-syndrome-a-systematic-review
#16
John R Richards, Brent K Gordon, Aaron R Danielson, Aimee K Moulin
OBJECTIVE: Cannabinoid hyperemesis syndrome (CHS) has become more prevalent with increasing cannabis use. CHS is often resistant to standard antiemetics. The objective of this study is to review the current evidence for pharmacologic treatment of CHS. METHODS: MEDLINE, PsycINFO, DARE, OpenGrey, Google Scholar, and the Cochrane Library were searched from inception to February 2017. Articles were selected and reviewed independently. Evidence was graded using Oxford CEBM guidelines...
March 31, 2017: Pharmacotherapy
https://www.readbyqxmd.com/read/28349496/a-phase-ii-randomized-double-blind-placebo-controlled-study-of-6-gingerol-as-an-anti-emetic-in-solid-tumor-patients-receiving-moderately-to-highly-emetogenic-chemotherapy
#17
RANDOMIZED CONTROLLED TRIAL
J Konmun, K Danwilai, N Ngamphaiboon, B Sripanidkulchai, A Sookprasert, S Subongkot
6-Gingerol is a natural compound extracted from ginger. Preclinical studies demonstrated that 6-gingerol has an anti-emetic activity by inhibiting neurokinin-1, serotonin, and dopamine receptors. Several clinical trials examined crude ginger powder for preventing chemotherapy-induced nausea and vomiting (CINV), but none of them was conducted with a standardized bioactive compound. Patients who received moderately to highly emetogenic adjuvant chemotherapy were randomized to receive 6-gingerol 10 mg or placebo orally twice daily for 12 weeks...
April 2017: Medical Oncology
https://www.readbyqxmd.com/read/28327932/integrated-safety-analysis-of-rolapitant-with-coadministered-drugs-from-phase-ii-iii-trials-an-assessment-of-cyp2d6-or-bcrp-inhibition-by-rolapitant
#18
S Barbour, T Smit, X Wang, D Powers, S Arora, V Kansra, M Aapro, J Herrstedt
Background: Rolapitant, a long-acting neurokinin (NK) 1 receptor antagonist (RA), has demonstrated efficacy in prevention of chemotherapy-induced nausea and vomiting in patients administered moderately or highly emetogenic chemotherapy. Unlike other NK 1 RAs, rolapitant does not inhibit or induce cytochrome P450 (CYP) 3A4, but it does inhibit CYP2D6 and breast cancer resistance protein (BCRP). To analyze potential drug-drug interactions between rolapitant and concomitant medications, this integrated safety analysis of four double-blind, randomized phase II or III studies of rolapitant examined adverse events by use versus non-use of drug substrates of CYP2D6 or BCRP...
February 23, 2017: Annals of Oncology: Official Journal of the European Society for Medical Oncology
https://www.readbyqxmd.com/read/28322837/role-of-prostanoid-ep3-1-receptors-in-mechanisms-of-emesis-and-defaecation-in-ferrets
#19
Kelvin K W Kan, Man K Wai, Robert L Jones, John A Rudd
Prostanoid EP receptor agonists are used for a number of clinical indications but may be associated with gastric disturbance. In the present studies we used the ferret and sulprostone (30µg/kg, i.p.) to investigate the role of EP3/1 receptors in mechanisms of emesis and defaecation. The emetic response was antagonized significantly by (+)-(2S,3S)-3-(2-methoxybenzylamino)-2-phenlypiperidine hydrochloride (CP-99,994; 10mg/kg, i.p.; P<0.05), but not by metoclopramide (0.3 and 3mg/kg), ondansetron (0.1 and 1mg/kg), or scopolamine (3mg/kg); promethazine (3mg/kg) potentiated emesis by approximately 82% (P<0...
May 15, 2017: European Journal of Pharmacology
https://www.readbyqxmd.com/read/28298780/effects-of-inhaled-nitrous-oxide-on-the-induction-dose-and-time-requirements-of-propofol-a-prospective-randomized-double-blind-study
#20
Kavita Jain, Surendra Kumar Sethi, Mamta Damor, Neena Jain
CONTEXT: Propofol is a commonly used induction agent during general anesthesia. As a sole agent, it does not provide any strong analgesic effect. The nitrous oxide (N2O) used along with propofol for induction of anesthesia augments the induction characteristics and reduces the dose of propofol. AIMS: To study the effects of inhaled N2O on the induction dose and time of propofol during general anesthesia and also its hemodynamic response and adverse effects. SETTINGS AND DESIGN: The present research is a prospective, randomized, double-blind comparative study...
January 2017: Anesthesia, Essays and Researches
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