keyword
MENU ▼
Read by QxMD icon Read
search

Ondansetron

keyword
https://www.readbyqxmd.com/read/29326489/ondansetron-ameliorates-depression-associated-with-obesity-in-high-fat-diet-fed-experimental-mice-an-investigation-based-on-the-behavioral-biochemical-and-molecular-approach
#1
Yeshwant Kurhe, Radhakrishnan Mahesh
INTRODUCTION: Obesity is an important risk factor for depression as more than half of the obese population is susceptible for depression at double rate. Our earlier studies reported the antidepressant potential of 5-HT3 receptor antagonist, ondansetron (OND) in depression associated obesity using behavioral tasks. The present research work is aimed to evaluate the effect of OND on depression associated with obesity with special emphasis on biochemical and molecular mechanisms such as hippocampal brain-derived neurotrophic factor (BDNF), cyclic adenosine monophosphate (cAMP), 5-hydroxytryptamine (5-HT), hippocampal histological examination and immunohistochemical expression of p53 proteins...
July 2017: Indian Journal of Pharmacology
https://www.readbyqxmd.com/read/29319439/successful-management-of-minoxidil-toxicosis-in-a-dog
#2
Tyler J M Jordan, Page E Yaxley, Christine A Culler, Anusha Balakrishnan
CASE DESCRIPTION A 2-year-old sexually intact female mixed-breed dog was evaluated at an emergency hospital approximately 5 hours after ingestion of an unknown amount of over-the-counter topical hair growth promoter containing 5% minoxidil foam. Vomiting and signs of lethargy were reported by the owner, and physical examination revealed tachycardia and hypotension. No treatments were performed, and the dog was transferred to a veterinary referral hospital for management of suspected minoxidil toxicosis. CLINICAL FINDINGS On arrival at the referral hospital, the dog was tachycardic (heart rate, 200 to 220 beats/min) and hypotensive (systolic arterial blood pressure, 70 mm Hg)...
January 15, 2018: Journal of the American Veterinary Medical Association
https://www.readbyqxmd.com/read/29317399/effect-of-a-single-dose-of-i-v-ondansetron-on-qtc-interval-in-emergency-department-patients
#3
Kai Li, Kathy Vo, Byron K Lee, Newton Addo, Zlatan Coralic
PURPOSE: Results of a study to determine whether i.v. administration of a single dose of 4 mg of ondansetron was associated with QT interval prolongation in emergency department (ED) patients are reported. METHODS: In a prospective observational study conducted at an urban academic medical center ED, a convenience sample of adult ED patients treated with ondansetron 4 mg i.v. were enrolled. A 12-lead electrocardiogram (ECG) was obtained immediately before and 5 minutes after ondansetron administration...
January 9, 2018: American Journal of Health-system Pharmacy: AJHP
https://www.readbyqxmd.com/read/29315462/aprepitant-as-a-fourth-antiemetic-prophylactic-strategy-in-high-risk-patients-a-double-blind-randomized-trial
#4
L C de Morais, A M Sousa, G F Flora, T R Grigio, G M N Guimarães, H A Ashmawi
BACKGROUND: Post-operative nausea and vomiting (PONV) is one of the most important causes of patient discomfort after laparoscopic surgeries despite the use of a multimodal pharmacological approach. This study assessed whether the addition of aprepitant to a multimodal regimen would further decrease the incidence of PONV in high-risk patients. METHODS: Apfel-score three or four patients, scheduled for laparoscopic procedures to treat abdominal or pelvic cancer, were randomized to receive oral starch (control group) or 80 mg of oral aprepitant (treatment group) before induction of anaesthesia in a double-blind study...
January 7, 2018: Acta Anaesthesiologica Scandinavica
https://www.readbyqxmd.com/read/29290374/physical-compatibility-of-meropenem-and-vaborbactam-with-select-intravenous-drugs-during-simulated-y-site-administration
#5
James M Kidd, Lindsay M Avery, Tomefa E Asempa, David P Nicolau, Joseph L Kuti
PURPOSE: Meropenem/vaborbactam is a novel intravenous antibiotic combining the carbapenem, meropenem, with a novel β-lactamase inhibitor, vaborbactam. Meropenem/vaborbactam is administered as a 3-hour infusion given every 8 hours, thereby potentially restricting an intravenous line for 9 h/d. Intravenous medications may be given concurrently via Y-site when compatibility data are available. Herein, physical compatibility was determined for the identification which medications can be coadministered with meropenem/vaborbactam via Y-site...
December 28, 2017: Clinical Therapeutics
https://www.readbyqxmd.com/read/29280949/peripheral-5-ht3-receptors-are-involved-in-the-antinociceptive-effect-of-bunodosine-391
#6
Wilson Alves Ferreira Junior, Andre Junqueira Zaharenko, Kohei Kazuma, Gisele Picolo, Vanessa Pacciari Gutierrez, Jose Carlos de Freitas, Katsuhiro Konno, Yara Cury
Bunodosine 391 (BDS 391), a low molecular weight compound isolated from the sea anemone Bunodosoma cangicum, increases the nociceptive threshold and inhibits inflammatory hyperalgesia. Serotonin receptors are involved in those effects. In this study, we have expanded the characterization of the antinociceptive effect of BDS 391 demonstrating that, in rats: (a) the compound inhibits (1.2-12 ng/paw) overt pain, in the formalin test, and mechanical hyperalgesia (0.6-6.0 ng/paw) detected in a model of neuropathic pain; (b) intraplantar administration of ondansetron, a selective 5-HT3 receptor antagonist, blocks the effect of BDS 391, whereas ketanserin, a 5-HT2 receptor antagonist, partially reversed this effect, indicating the involvement of peripheral 5-HT2 and 5-HT3 receptors in BDS 391 antinociception; and (c) in binding assay studies, BDS 391 was not able to displace the selective 5-HT receptor antagonists, suggesting that this compound does not directly bind to these receptors...
December 27, 2017: Toxins
https://www.readbyqxmd.com/read/29278818/ondansetron-does-not-prevent-physical-dependence-in-patients-taking-opioid-medications-chronically-for-pain-control
#7
Larry F Chu, Tom Rico, Erika Cornell, Hannah Obasi, Ellen M Encisco, Haley Vertelney, Jamison G Gamble, Clayton W Crawford, John Sun, Anna Clemenson, Matthew J Erlendson, Robin Okada, Ian Carroll, J David Clark
OBJECTIVES: In this study, we investigated the co-administration of ondansetron with morphine, and whether it could prevent the development of physical dependence in patients taking opioids for the treatment of chronic pain. METHODS: A total of 48 chronic back pain patients (N = 48) participated in this double-blinded, placebo-controlled, randomized study. Patients were titrated onto sustained-release oral morphine and randomized to take 8 mg ondansetron or placebo three times daily concurrently with morphine during the 30-day titration...
August 14, 2017: Drug and Alcohol Dependence
https://www.readbyqxmd.com/read/29275640/lost-in-translation-a-critical-look-at-the-role-that-animal-models-of-obsessive-compulsive-disorder-play-in-current-drug-discovery-strategies
#8
Kurt Leroy Hoffman, Hugo Cano-Ramírez
Obsessive-compulsive disorder (OCD) is a severe neuropsychiatric illness estimated to affect between 1-3% of the population. In today's literature, there are a number well-validated and convincing animal models of OCD described. Areas covered: Herein, the authors look at the role that animal models of OCD (including transgenic models, deer mouse stereotypy, quinpirole sensitization, post-training signal attenuation, and mouse marble burying) have played in determining the current directions of OCD drug discovery...
December 23, 2017: Expert Opinion on Drug Discovery
https://www.readbyqxmd.com/read/29274875/the-multimodal-antidepressant-vortioxetine-may-facilitate-pyramidal-cell-firing-by-inhibition-of-5-ht3-receptor-expressing-interneurons-an-in-vitro-study-in-rat-hippocampus-slices
#9
Elena Dale, Morten Grunnet, Alan L Pehrson, Kristen Frederiksen, Peter H Larsen, Jacob Nielsen, Tine B Stensbøl, Bjarke Ebert, Haolan Yin, Dunguo Lu, Huiquing Liu, Thomas N Jensen, Charles R Yang, Connie Sanchez
The multimodal antidepressant vortioxetine is thought to mediate its pharmacological effects via 5-HT1A receptor agonism, 5-HT1B receptor partial agonism, 5-HT1D, 5-HT3, 5-HT7 receptor antagonism and 5-HT transporter inhibition. Here we studied vortioxetine's functional effects across species (canine, mouse, rat, guinea pig and human) in cellular assays with heterologous expression of 5-HT3A receptors (in Xenopus oocytes and HEK-293 cells) and in mouse neuroblastoma N1E-115 cells with endogenous expression of 5-HT3A receptors...
December 21, 2017: Brain Research
https://www.readbyqxmd.com/read/29273901/systematic-review-of-combined-pharmacotherapy-for-the-treatment-of-alcohol-use-disorder-in-patients-without-comorbid-conditions
#10
REVIEW
Andrew C Naglich, Austin Lin, Sidarth Wakhlu, Bryon H Adinoff
BACKGROUND: Previous reviews have examined the use of theoretically supported combinations of drugs for the treatment of alcohol use disorder. This review seeks to examine the strengths and limitations of current clinical evidence for the use of combined pharmacological interventions intended to treat alcohol use disorder. OBJECTIVES: The objective of this review was to identify combinations of pharmacological treatments for alcohol use disorder, and assess the strength of clinical evidence for these treatments...
December 22, 2017: CNS Drugs
https://www.readbyqxmd.com/read/29259513/torsades-de-pointes-after-ondansetron-infusion-in-2-patients
#11
Danny Y Lee, Tri Trinh, Sion K Roy
Drugs that prolong the electrocardiographic QT interval increase the risk of ventricular arrhythmias, particularly torsades de pointes. Ondansetron, a 5-hydroxytryptamine type 3 receptor antagonist antiemetic, is one such drug. We present the cases of 2 patients who were given intravenous ondansetron and subsequently developed torsades de pointes. Both had normal QT intervals at baseline but were discovered to have risk factors that predisposed them to drug-induced QT prolongation and ventricular arrhythmias...
October 2017: Texas Heart Institute Journal
https://www.readbyqxmd.com/read/29258478/pregnancy-prescription-medicines-and-the-potential-risk-of-herb-drug-interactions-a-cross-sectional-survey
#12
James S McLay, Naila Izzati, Abdul R Pallivalapila, Ashalatha Shetty, Binita Pande, Craig Rore, Moza Al Hail, Derek Stewart
BACKGROUND: Pregnant women are routinely prescribed medicines while self-medicating with herbal natural products to treat predominantly pregnancy related conditions. The aim of this study was to assess the potential for herb-drug interactions (HDIs) in pregnant women and to explore possible herb-drug interactions and their potential clinical significance. METHODS: A cross-sectional survey of women during early pregnancy or immediately postpartum in North-East Scotland...
December 19, 2017: BMC Complementary and Alternative Medicine
https://www.readbyqxmd.com/read/29247960/application-of-miniaturized-near-infrared-spectroscopy-for-quality-control-of-extemporaneous-orodispersible-films
#13
Wen Chin Foo, Effendi Widjaja, Yuet Mei Khong, Rajeev Gokhale, Sui Yung Chan
Extemporaneous oral preparations are routinely compounded in the pharmacy due to a lack of suitable formulations for special populations. Such small-scale pharmacy preparations also present an avenue for individualized pharmacotherapy. Orodispersible films (ODF) have increasingly been evaluated as a suitable dosage form for extemporaneous oral preparations. Nevertheless, as with all other extemporaneous preparations, safety and quality remain a concern. Although the United States Pharmacopeia (USP) recommends analytical testing of compounded preparations for quality assurance, pharmaceutical assays are typically not routinely performed for such non-sterile pharmacy preparations, due to the complexity and high cost of conventional assay methods such as high performance liquid chromatography (HPLC)...
December 13, 2017: Journal of Pharmaceutical and Biomedical Analysis
https://www.readbyqxmd.com/read/29243058/does-prophylactic-ondansetron-reduce-norepinephrine-consumption-in-patients-undergoing-cesarean-section-with-spinal-anesthesia
#14
Feride Karacaer, Ebru Biricik, İlker Ünal, Selim Büyükkurt, Hakkı Ünlügenç
PURPOSE: Spinal anesthesia-induced hypotension (SAIH) during cesarean delivery is not rare and frequently leads to materno-fetal discrepancy and collapse. More recently, norepinephrine has been proposed for the prevention and treatment of SAIH with fewer tendencies to decrease heart rate and cardiac output. Ondansetron has been reported to reduce the incidence of SAIH in patients undergoing cesarean section. The aim of the present study was to assess the effect of prophylactic ondansetron on the incidence of SAIH, norepinephrine consumption, and adverse effects...
December 14, 2017: Journal of Anesthesia
https://www.readbyqxmd.com/read/29234184/a-rare-case-of-fixed-drug-eruption-due-to-ondansetron
#15
Aditi Maitra, Shashwat Bhattacharyya, Sabyasachi Paik, Prerna Pathak, Santanu Kumar Tripathi
Fixed drug eruption (FDE) is a unique type of cutaneous drug reaction that typically recurs in the identical locations on re-exposure to the attributed drug. FDE is characterized by the appearance of a single or multiple sharply demarcated violaceous erythematous plaques which heal with residual hyperpigmentation. A 27-year-old woman presented with multiple dark patches over her eyelids, mouth, lips, and shoulders of 1 week's duration. These lesions followed multiple erythematous plaques over the same areas which appeared within 4 hours of the intake of an ondansetron tablet, 12 days previously...
September 2017: Iranian Journal of Medical Sciences
https://www.readbyqxmd.com/read/29225684/colon-cancer-presenting-as-pseudo-obstruction-during-pregnancy-a-case-report
#16
Reeva Makhijani, Vicky H Bhagat, Mariam Fayek
The incidence of colorectal cancer in pregnancy is between 0.002 and 0.008%. Diagnosis is often delayed as symptoms of colorectal cancer can mimic as common complaints of pregnancy. We present the case of a 29-year-old with a history of chronic constipation who presented in the second trimester with abdominal pain, inability to tolerate anything orally and no bowel movement in more than three weeks. Non-contrast MRI at presentation failed to show an obstructing mass. Patient was treated conservatively for presumed pseudo-obstruction secondary to worsening constipation from chronic ondansetron use and pregnancy...
December 2017: Obstetric Medicine
https://www.readbyqxmd.com/read/29206644/antinociceptive-and-antioxidant-activities-of-hunteria-umbellata-stem-bark-possible-role-of-the-serotonergic-opioidergic-and-dopaminergic-pathways
#17
Osaze Edosuyi, Ighodaro Igbe, Loretta Oghenekome Iniaghe
Background Hunteria umbellata (HU) (K. Schum) is used in ethnomedicine for the management of pain, diabetes mellitus and dysmenorrhoea. This study evaluated the analgesic and antioxidant activities of aqueous extract of HU stem bark and the possible mechanism(s) of action. Methods The antinociceptive effect of HU was evaluated using acetic acid mouse writhing, tail flick, hot plate and formalin-induced paw licking models. To establish the possible mechanism(s) of action of HU, separate group of animals were pretreated with naloxone (1 mg/kg, i...
December 5, 2017: Journal of Complementary & Integrative Medicine
https://www.readbyqxmd.com/read/29189312/hypoglycemia-and-sudden-death-during-treatment-with-methadone-for-opiate-detoxification
#18
Christopher J Plescia, Peter Manu
CLINICAL FEATURES: We present a case of a middle-aged man admitted to an inpatient detoxification facility for withdrawal of intranasal heroin, alprazolam, and ethanol. The patient was placed on methadone and chlordiazepoxide tapers. Ondansetron and trazodone were prescribed as needed for symptom control. On the third hospital day, the patient was found unresponsive with blood glucose of 40 mg/dL. He had no history of glucose dysregulation. The patient was pronounced dead shortly thereafter...
November 14, 2017: American Journal of Therapeutics
https://www.readbyqxmd.com/read/29141182/optogenetic-activation-of-5-ht-neurons-in-the-dorsal-raphe-suppresses-seizure-induced-respiratory-arrest-and-produces-anticonvulsant-effect-in-the-dba-1-mouse-sudep-model
#19
Honghai Zhang, Haiting Zhao, Chang Zeng, Christa Van Dort, Carl L Faingold, Norman E Taylor, Ken Solt, Hua-Jun Feng
Sudden unexpected death in epilepsy (SUDEP) is a devastating epilepsy complication. Seizure-induced respiratory arrest (S-IRA) occurs in many witnessed SUDEP patients and animal models as an initiating event leading to death. Thus, understanding the mechanisms underlying S-IRA will advance the development of preventive strategies against SUDEP. Serotonin (5-HT) is an important modulator for many vital functions, including respiration and arousal, and a deficiency of 5-HT signaling is strongly implicated in S-IRA in animal models, including the DBA/1 mouse...
November 13, 2017: Neurobiology of Disease
https://www.readbyqxmd.com/read/29135900/ondansetron-prescription-for-home-use-in-a-pediatric-emergency-department
#20
James M Gray, Jaya D Maewal, Scott A Lunos, Ronald A Furnival, Marissa A Hendrickson
OBJECTIVES: Ondansetron has been shown to decrease admission rates and the need for intravenous fluids among pediatric emergency department (ED) patients with acute gastroenteritis, but there is limited evidence regarding its use after ED discharge. This study describes prescribing patterns for ondansetron and assesses the effects of ondansetron home prescription on rate of return. METHODS: Data were gathered from the electronic health record on 2 separate but overlapping groups of patients seen in a pediatric ED from 2012 to 2014...
November 14, 2017: Pediatric Emergency Care
keyword
keyword
14907
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"