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https://www.readbyqxmd.com/read/29035833/vanillic-acid-attenuates-effects-of-transient-bilateral-common-carotid-occlusion-and-reperfusion-in-rats
#1
Seyed Esmaeil Khoshnam, Alireza Sarkaki, Layasadat Khorsandi, William Winlow, Mohammad Badavi, Hadi Fathi Moghaddam, Yaghoob Farbooda
Cerebral hypoperfusion induced by transient bilateral common carotid arteries occlusion (tBCCAO), is associated with deleterious alterations in several physiological parameters of the animals. This study aims to investigate the effects of vanillic acid (VA) on memory impairment, locomotion and exploratory deficits, as well as histological and hippocampal long-term potentiation (LTP) injuries induced by tBCCAO procedure followed by reperfusion (BCCAO/R) in rats. Adult male Wistar rats (250-300g) were divided randomly into four groups: Sham-Operated group "Sham"; Vehicle+BCCAO/R group "BCCAO/R"; Vehicle+ Vanillic acid group "VA"; VA (100mg/kg) +BCCAO/R group "VA +BCCAO/R"...
October 13, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/29034691/combined-transarterial-chemoembolization-and-radiofrequency-ablation-for-small-treatment-na%C3%A3-ve-hepatocellular-carcinoma-infeasible-for-ultrasound-guided-radiofrequency-ablation-long-term-outcomes
#2
Dongho Hyun, Sung Ki Cho, Sung Wook Shin, Kwang Bo Park, Sang Yub Lee, Hong Suk Park, Young Soo Do
Background Ultrasound (US)-guided radiofrequency ablation (RFA) for small hepatocellular carcinoma (HCC) is often infeasible due to unfavorable location and poor conspicuity. Those small HCCs can be treated with combined transarterial chemoembolization (TACE) and RFA. Purpose To evaluate long-term outcomes of combined TACE and RFA for small treatment-naïve HCC infeasible for US-guided RFA. Material and Methods Between February 2009 and January 2014, 69 patients with small (≤3 cm) HCC infeasible for US-guided RFA received TACE and subsequent RFA in one session as a first-line treatment...
January 1, 2017: Acta Radiologica
https://www.readbyqxmd.com/read/29029986/radiofrequency-ablation-for-colorectal-cancer-liver-metastases-initially-greater-than-25%C3%A2-mm-but-downsized-by-neo-adjuvant-chemotherapy-is-associated-with-increased-rate-of-local-tumor-progression
#3
Léonor Benhaim, Mostafa El Hajjam, Robert Malafosse, Jacques Sellier, Catherine Julie, Alain Beauchet, Bernard Nordlinger, Frédérique Peschaud
BACKGROUND: Radiofrequency ablation (RFA) is a valid treatment for liver metastases from colorectal cancer (CRLM) smaller than 25 mm and unsuitable for surgical resection. Tumor size is predictive for local tumor progression (LTP). The aim of this study was to evaluate whether RFA is indicated for lesions >25 mm at presentation but <25 mm after chemotherapy. METHOD: Patients who underwent RFA for CRLM after chemotherapy (January 2004-December 2012) were reviewed...
October 10, 2017: HPB: the Official Journal of the International Hepato Pancreato Biliary Association
https://www.readbyqxmd.com/read/29029497/kras-mutation-is-a-marker-of-worse-oncologic-outcomes-after-percutaneous-radiofrequency-ablation-of-colorectal-liver-metastases
#4
Waleed Shady, Elena N Petre, Efsevia Vakiani, Etay Ziv, Mithat Gonen, Karen T Brown, Nancy E Kemeny, Stephen B Solomon, David B Solit, Constantinos T Sofocleous
BACKGROUND: Kras mutation has been associated with shorter overall survival and time to disease recurrence after resection of colorectal liver metastases (CLM). This study evaluated the prognostic value of Kras mutation in patients with CLM treated by percutaneous radiofrequency ablation (RFA). METHODS: This is an IRB waived retrospective analysis of the impact of KRAS mutation status on oncologic outcomes after CLM RFA. The endpoints were overall survival (OS), local tumor progression (LTP) rates, and incidence of new liver, lung, and peritoneal metastases...
September 12, 2017: Oncotarget
https://www.readbyqxmd.com/read/29021765/enhancing-neuroplasticity-to-augment-cognitive-remediation-in-schizophrenia
#5
REVIEW
Carol Jahshan, Yuri Rassovsky, Michael F Green
There is a burgeoning need for innovative treatment strategies to improve the cognitive deficits in schizophrenia. Cognitive remediation (CR) is effective at the group level, but the variability in treatment response is large. Given that CR may depend on intact neuroplasticity to produce cognitive gains, it is reasonable to combine it with strategies that harness patients' neuroplastic potential. In this review, we discuss two non-pharmacological approaches that can enhance neuroplasticity and possibly augment the effects of CR in schizophrenia: physical exercise and transcranial direct current stimulation (tDCS)...
2017: Frontiers in Psychiatry
https://www.readbyqxmd.com/read/29019861/the-lateral-thigh-perforator-ltp-flap-for-autologous-breast-reconstruction-a-prospective-analysis-of-138-flaps
#6
Stefania M H Tuinder, Jop Beugels, Arno Lataster, Michiel W de Haan, Andrzej Piatkowski, Michel Saint-Cyr, René R W J van der Hulst, Robert J Allen
BACKGROUND: The septocutaneous tensor fasciae latae (sc-TFL) or lateral thigh perforator (LTP) flap was previously introduced by our group as an alternative flap for autologous breast reconstruction when the abdomen is not suitable as a donor site. The aim of this study was to analyze our experience with the LTP flap and to present the surgical refinements that were introduced. METHODS: A prospective study was conducted of all LTP flap breast reconstructions performed since September 2012...
October 10, 2017: Plastic and Reconstructive Surgery
https://www.readbyqxmd.com/read/28988860/theta-phase-synchronization-is-the-glue-that-binds-human-associative-memory
#7
Andrew Clouter, Kimron L Shapiro, Simon Hanslmayr
Episodic memories are information-rich, often multisensory events that rely on binding different elements [1]. The elements that will constitute a memory episode are processed in specialized but distinct brain modules. The binding of these elements is most likely mediated by fast-acting long-term potentiation (LTP), which relies on the precise timing of neural activity [2]. Theta oscillations in the hippocampus orchestrate such timing as demonstrated by animal studies in vitro [3, 4] and in vivo [5, 6], suggesting a causal role of theta activity for the formation of complex memory episodes, but direct evidence from humans is missing...
October 4, 2017: Current Biology: CB
https://www.readbyqxmd.com/read/28987281/the-effects-of-the-5-ht7-receptor-on-hippocampal-long-term-potentiation-and-apoptosis-in-a-rat-model-of-alzheimer-s-disease
#8
Nasrin Hashemi-Firouzi, Alireza Komaki, Sara Soleimani Asl, Siamak Shahidi
Alzheimer's disease (AD) is the most common neurodegenerative disorder involving synaptic loss and impairments in learning and memory. Long-term potentiation (LTP) of synaptic function is a model of learning- and memory-related neural plasticity, of which serotonin (5-HT) is a key modulator in the hippocampus. As the 5-HT7 receptor subtype is implicated in hippocampal neuronal function, dendritic rearrangement, and neurogenesis, the aim of this study was to assess the effect of 5-HT7 receptor activation on hippocampal synaptic plasticity and apoptosis in a rat model of AD...
October 5, 2017: Brain Research Bulletin
https://www.readbyqxmd.com/read/28986104/the-effects-of-betulinic-acid-on-neurobehavioral-activity-electrophysiology-and-histological-changes-in-an-animal-model-of-the-alzheimer-s-disease
#9
Seyedeh Parisa Navabi, Alireza Sarkaki, Esrafil Mansouri, Mohammad Badavi, Ata Ghadiri, Yaghoob Farbood
Alzheimer's disease (AD) is a common disorder characterized by aggregation and conversion of amyloid beta (Aβ) monomers to fibrils. Betulinic acid (BA) strongly accelerated this pathway through circumventing the oligomeric intermediate state. BA at doses of 0.2 and 0.4μM/10μl/rat (intra-hippocampal or i.h injection, vehicle: DMSO) was bilaterally administrated 180 and 10min before co-administration of Aβ (0.1μM/5μl/rat, i.h injection, vehicle: PBS) and Streptozotocin (STZ, 1.5mg/kg/10μl/rat, intracerebroventricular or i...
October 3, 2017: Behavioural Brain Research
https://www.readbyqxmd.com/read/28983834/correction-to-prevention-by-regular-exercise-of-acute-sleep-deprivation-induced-impairment-of-late-phase-ltp-and-related-signaling-molecules-in-the-dentate-gyrus
#10
Munder A Zagaar, An T Dao, Ibrahim A Alhaider, Karim A Alkadhi
The original version of this article unfortunately does not include the second affiliating institution of Dr. Munder A. Zagaar. "Department of Pharmacy Pracce and Clinical Health Sciences, Texas Southern University, Houston, TX 77004" should have been included on the paper.
October 5, 2017: Molecular Neurobiology
https://www.readbyqxmd.com/read/28983832/correction-to-comparison-of-the-effect-of-exercise-on-late-phase-ltp-of-the-dentate-gyrus-and-ca1-of-alzheimer-s-disease-model
#11
An T Dao, Munder A Zagaar, Amber T Levine, Karim A Alkadhi
The original version of this article unfortunately does not include the second affiliating institution of Dr. Munder A. Zagaar. "Department of Pharmacy Pracce and Clinical Health Sciences, Texas Southern University, Houston, TX 77004" should have been included on the paper.
October 5, 2017: Molecular Neurobiology
https://www.readbyqxmd.com/read/28983661/low-kv-versus-dual-energy-virtual-monoenergetic-ct-imaging-for-proven-liver-lesions-what-are-the-advantages-and-trade-offs-in-conspicuity-and-image-quality-a-pilot-study
#12
G Jay Hanson, Gregory J Michalak, Robert Childs, Brian McCollough, Anil N Kurup, David M Hough, Judson M Frye, Jeff L Fidler, Sudhakar K Venkatesh, Shuai Leng, Lifeng Yu, Ahmed F Halaweish, W Scott Harmsen, Cynthia H McCollough, J G Fletcher
PURPOSE: Single-energy low tube potential (SE-LTP) and dual-energy virtual monoenergetic (DE-VM) CT images both increase the conspicuity of hepatic lesions by increasing iodine signal. Our purpose was to compare the conspicuity of proven liver lesions, artifacts, and radiologist preferences in dose-matched SE-LTP and DE-VM images. METHODS: Thirty-one patients with 72 proven liver lesions (21 benign, 51 malignant) underwent full-dose contrast-enhanced dual-energy CT (DECT)...
October 5, 2017: Abdominal Radiology
https://www.readbyqxmd.com/read/28981400/clinical-outcomes-of-radiofrequency-ablation-for-early-hypovascular-hcc-a-multicenter-retrospective-study
#13
Dong Ho Lee, Jeong Min Lee, Tae Wook Kang, Hyunchul Rhim, So Yeon Kim, Yong Moon Shin, Jung Wook Seo, Moon Hyung Choi, Kyung Bun Lee
Purpose To retrospectively evaluate the clinical outcomes of radiofrequency ablation (RFA) for early hypovascular hepatocellular carcinomas (HCCs) and to compare them with those of typical hypervascular HCCs. Materials and Methods This retrospective multicenter study received institutional review board approval, with a waiver of the need to obtain informed consent. A total of 56 patients (male-to-female ratio, 40:16; mean age, 61.8 years; age range, 33-87 years) with pathologically proven early HCCs that did not meet the noninvasive diagnosis criteria and who were initially treated with RFA at one of five university-affiliated hospitals between January 2009 and December 2013 comprised the study group...
October 5, 2017: Radiology
https://www.readbyqxmd.com/read/28979192/arc-interacts-with-the-integral-endoplasmic-reticulum-protein-calnexin
#14
Craig Myrum, Jonathan Soulé, Margarethe Bittins, Kyle Cavagnini, Kevin Goff, Silje K Ziemek, Maria S Eriksen, Sudarshan Patil, Adrian Szum, Rajeevkumar R Nair, Clive R Bramham
Activity-regulated cytoskeleton-associated protein, Arc, is a major regulator of long-term synaptic plasticity and memory formation. Here we reveal a novel interaction partner of Arc, a resident endoplasmic reticulum transmembrane protein, calnexin. We show an interaction between recombinantly-expressed GST-tagged Arc and endogenous calnexin in HEK293, SH-SY5Y neuroblastoma and PC12 cells. The interaction was dependent on the central linker region of the Arc protein that is also required for endocytosis of AMPA-type glutamate receptors...
2017: Frontiers in Cellular Neuroscience
https://www.readbyqxmd.com/read/28979184/spin90-modulates-long-term-depression-and-behavioral-flexibility-in-the-hippocampus
#15
Dae Hwan Kim, Minkyung Kang, Chong-Hyun Kim, Yun Hyun Huh, In Ha Cho, Hyun-Hee Ryu, Kyung Hwun Chung, Chul-Seung Park, Sangmyung Rhee, Yong-Seok Lee, Woo Keun Song
The importance of actin-binding proteins (ABPs) in the regulation of synapse morphology and plasticity has been well established. SH3 protein interacting with Nck, 90 kDa (SPIN90), an Nck-interacting protein highly expressed in synapses, is essential for actin remodeling and dendritic spine morphology. Synaptic targeting of SPIN90 to spine heads or dendritic shafts depends on its phosphorylation state, leading to blockage of cofilin-mediated actin depolymerization and spine shrinkage. However, the physiological role of SPIN90 in long-term plasticity, learning and memory are largely unknown...
2017: Frontiers in Molecular Neuroscience
https://www.readbyqxmd.com/read/28978486/grip1-binds-to-apoer2-and-ephrinb2-to-induce-activity-dependent-ampa-receptor-insertion-at-the-synapse
#16
Sylvia Pfennig, Franziska Foss, Diane Bissen, Eva Harde, Julia C Treeck, Marta Segarra, Amparo Acker-Palmer
Regulation of α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptor trafficking in response to neuronal activity is critical for synaptic function and plasticity. Here, we show that neuronal activity induces the binding of ephrinB2 and ApoER2 receptors at the postsynapse to regulate de novo insertion of AMPA receptors. Mechanistically, the multi-PDZ adaptor glutamate-receptor-interacting protein 1 (GRIP1) binds ApoER2 and bridges a complex including ApoER2, ephrinB2, and AMPA receptors. Phosphorylation of ephrinB2 in a serine residue (Ser-9) is essential for the stability of such a complex...
October 3, 2017: Cell Reports
https://www.readbyqxmd.com/read/28975698/dopamine-d4-receptor-activation-restores-ca1-ltp-in-hippocampal-slices-from-aged-mice
#17
Fangli Guo, Jianhua Zhao, Dandan Zhao, Jiangang Wang, Xiaofang Wang, Zhiwei Feng, Martin Vreugdenhil, Chengbiao Lu
Normal aging is characterized with a decline in hippocampal memory functions that is associated with changes in long-term potentiation (LTP) of the CA3-to-CA1 synapse. Age-related deficit of the dopaminergic system may contribute to impairment of CA1 LTP. Here we assessed how the modulation of CA1 LTP by dopamine is affected by aging and how it is dependent on the Ca(2+) source. In slices from adult mice, the initial slope of the field potential showed strong LTP, but in slices from aged mice LTP was impaired...
October 3, 2017: Aging Cell
https://www.readbyqxmd.com/read/28975565/inhibition-of-%C3%AE-ark1-ameliorates-morphine-induced-tolerance-and-hyperalgesia-via-modulating-the-activity-of-spinal-nmda-receptors
#18
Xue Zhang, Shaorui Chen, Hong Chen, Huilin Pan, Yilin Zhao
Our previous study has proposed that increased presynaptic NMDARs activities play pivotal roles in the development of opioid tolerance and hyperalgesia, and blocking spinal NMDARs attenuates chronic morphine-induced synaptic plasticity and behavior. However, the cellular signaling mechanisms remain to be investigated. The aim of this research was to address the role of β-ARK1 in opioid analgesia. Opioid tolerance and hyperalgesia was induced by daily systemic morphine injections in rats for eight consecutive days...
October 3, 2017: Molecular Neurobiology
https://www.readbyqxmd.com/read/28973908/substance-p-induces-plasticity-and-synaptic-tagging-capture-in-rat-hippocampal-area-ca2
#19
Ananya Dasgupta, Nimmi Baby, Kumar Krishna, Muhammad Hakim, Yuk Peng Wong, Thomas Behnisch, Tuck Wah Soong, Sreedharan Sajikumar
The hippocampal area Cornu Ammonis (CA) CA2 is important for social interaction and is innervated by Substance P (SP)-expressing supramammillary (SuM) nucleus neurons. SP exerts neuromodulatory effects on pain processing and central synaptic transmission. Here we provide evidence that SP can induce a slowly developing NMDA receptor- and protein synthesis-dependent potentiation of synaptic transmission that can be induced not only at entorhinal cortical (EC)-CA2 synapses but also at long-term potentiation (LTP)-resistant Schaffer collateral (SC)-CA2 synapses...
September 25, 2017: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/28968827/learning-similar-actions-by-reinforcement-or-sensory-prediction-errors-rely-on-distinct-physiological-mechanisms
#20
Shintaro Uehara, Firas Mawase, Pablo Celnik
Humans can acquire knowledge of new motor behavior via different forms of learning. The two forms most commonly studied have been the development of internal models based on sensory-prediction errors (error-based learning) and success-based feedback (reinforcement learning). Human behavioral studies suggest these are distinct learning processes, though the neurophysiological mechanisms that are involved have not been characterized. Here, we evaluated physiological markers from the cerebellum and the primary motor cortex (M1) using noninvasive brain stimulations while healthy participants trained finger-reaching tasks...
September 14, 2017: Cerebral Cortex
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