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https://www.readbyqxmd.com/read/29140849/endoscopic-submucosal-dissection-for-superficial-proximal-esophageal-neoplasia-is-highly-successful
#1
Yi-Qun Zhang, Tao Chen, Chen Zhang, Quan-Lin Li, Wei-Feng Chen, Li-Qing Yao, Ping-Hong Zhou, Mei-Dong Xu
OBJECTIVE: The aim of this study was to evaluate the outcomes of endoscopic submucosal dissection (ESD) for superficial proximal esophageal neoplasia. SUMMARY OF BACKGROUND DATA: The surgery for a tumor located in proximal esophagus is relatively difficult and leads to a high morbidity and mortality. ESD is a minimally invasive endoscopic treatment of superficial neoplasia of the gastrointestinal tract allowing en block resection with low recurrence rates; however, ESD for superficial proximal esophageal neoplasia is little known...
December 2017: Annals of Surgery
https://www.readbyqxmd.com/read/29130978/peritoneal-seeding-after-gastric-perforation-during-endoscopic-submucosal-dissection-for-gastric-cancer
#2
Motohiro Hirao, Takuya Yamada, Tomoki Michida, Kazuhiro Nishikawa, Takuya Hamakawa, Eiji Mita, Masayuki Mano, Mitsugu Sekimoto
BACKGROUND/AIMS: Since the risk of cancer cells seeding the peritoneum after perforation during endoscopic submucosal dissection (ESD) is unclear, we retrospectively examined peritoneal relapse after gastric perforation during ESD for gastric cancer at a single institution. METHODS: Of 876 patients who underwent ESD for early gastric cancer between January 2002 and December 2015, 22 patients (2.5%) experienced gastric perforation during ESD at the Osaka National Hospital in Osaka, Japan...
November 8, 2017: Digestive Surgery
https://www.readbyqxmd.com/read/29129090/screening-and-prevention-strategies-and-endoscopic-management-of-early-esophageal-cancer
#3
James A Kim, Pari M Shah
Esophageal cancer is the 8th most common cancer worldwide and the 6th most common cause of cancer-related death. Its two main subtypes, esophageal adenocarcinoma (EAC) and esophageal squamous cell carcinoma (ESCC), have varying incidences globally, but recent decades have seen a demonstrated rise of EAC in Western countries whereas ESCC remains highly prevalent in Eastern Africa, Central Asia, and China. Screening interventions have focused on using endoscopy to identify Barrett's esophagus (BE) as a precursor to EAC, and squamous cell dysplasia prior to onset of ESCC...
October 2017: Chinese Clinical Oncology
https://www.readbyqxmd.com/read/29127731/endoscopic-submucosal-dissection-of-early-gastric-neoplasms-in-the-fornix-using-the-newly-developed-scissors-type-sb-knife-gx
#4
Yuki Sumida, Toshio Kuwai, Sauid Ishaq
Endoscopic submucosal dissection (ESD) using a scissors-type knife, the Stag-Beetle knife (SB knife, Sumitomo Bakelite, Tokyo, Japan), is considered technically easy and safe due to its ability to grasp the target tissue to allow controlled resection without the complex endoscopic tip control required with conventional ESD devices. There are two types of SB knife (short-type and Jr-type), used mainly for esophageal and colorectal neoplasms (1-3). Recently, a new type, SB knife GX, has been developed for gastric ESD...
November 11, 2017: Digestive Endoscopy: Official Journal of the Japan Gastroenterological Endoscopy Society
https://www.readbyqxmd.com/read/29124126/safe-management-of-laparoscopic-endoscopic-cooperative-surgery-for-superficial-non-ampullary-duodenal-epithelial-tumors
#5
Yasunori Otowa, Shingo Kanaji, Yoshinori Morita, Satoshi Suzuki, Masashi Yamamoto, Yoshiko Matsuda, Takeru Matsuda, Taro Oshikiri, Tetsu Nakamura, Fumiaki Kawara, Shinwa Tanaka, Tsukasa Ishida, Takashi Toyonaga, Takeshi Azuma, Yoshihiro Kakeji
Background and study aims  Endoscopic submucosal dissection (ESD) for duodenal tumors results in a high delayed perforation rate due to the thinness of the duodenal wall. In most cases with perforation after duodenal ESD, additional surgery is needed due to severe peritonitis. A newly developed procedure, laparoscopic endoscopic cooperative surgery for duodenal tumors (D-LECS), may help to avoid perforation after ESD. In our institution, patients with superficial non-ampullary duodenal epithelial tumors (SNADET) smaller than 50 mm which could not have en-bloc resection by endoscopic mucosal resection were treated with D-LECS...
November 2017: Endoscopy International Open
https://www.readbyqxmd.com/read/29122603/the-role-of-colorectal-endoscopic-submucosal-dissection-in-patients-with-ulcerative-colitis
#6
Satoshi Kinoshita, Toshio Uraoka, Toshihiro Nishizawa, Makoto Naganuma, Yasushi Iwao, Yasutoshi Ochiai, Ai Fujimoto, Osamu Goto, Masayuki Shimoda, Haruhiko Ogata, Takanori Kanai, Naohisa Yahagi
BACKGROUND AND AIM: Patients with ulcerative colitis have an increased risk of colorectal dysplasia. Endoscopic submucosal dissection (ESD) for the neoplastic lesions in ulcerative colitis remains controversial. The aim of this study was to clarify the role of ESD in treatment strategy for ulcerative colitis. METHODS: We retrospectively investigated 25 patients with ulcerative colitis in clinical remission who underwent colorectal ESD at two referral centers. We analyzed short-term and long-term outcomes...
November 6, 2017: Gastrointestinal Endoscopy
https://www.readbyqxmd.com/read/29122602/utility-of-multi-detector-ct-scans-after-colorectal-endoscopic-submucosal-dissection-a-prospective-study
#7
Ryosuke Kobayashi, Kingo Hirasawa, Chiko Sato, Makomo Makazu, Hiroaki Kaneko, Ryosuke Ikeda, Takehide Fukuchi, Atsushi Sawada, Yuichiro Ozeki, Masataka Taguri, Shigeo Takebayashi, Maeda Shin
BACKGROUND AND AIMS: Several reports have described the major adverse events after endoscopic submucosal dissection (ESD), such as perforation or bleeding. However, few studies have discussed the occurrence of post-ESD electrocoagulation syndrome (PEECS) after colorectal ESD. Additionally, the occurrence of fever without abdominal pain in patients requires postoperative management similar to that required for PEECS. Therefore, we have defined post-ESD inflammatory syndrome (PEIS) as composed of both PEECS and fever without abdominal pain...
November 6, 2017: Gastrointestinal Endoscopy
https://www.readbyqxmd.com/read/29113564/evaluating-the-quality-of-shape-data-simulated-by-k-mers-for-rna-structure-prediction
#8
Soheila Montaseri, Fatemeh Zare-Mirakabad, Mohammad Ganjtabesh
Finding an effective measure to predict a more accurate RNA secondary structure is a challenging problem. In the last decade, an experimental method, known as selective [Formula: see text]-hydroxyl acylation analyzed by primer extension (SHAPE), was proposed to measure the tendency of forming a base pair for almost all nucleotides in an RNA sequence. These SHAPE reactivities are then utilized to improve the accuracy of RNA structure prediction. Due to a significant impact of SHAPE reactivity and in order to reduce the experimental costs, we propose a new model called HL-k-mer...
October 19, 2017: Journal of Bioinformatics and Computational Biology
https://www.readbyqxmd.com/read/29110635/a-modified-endoscopic-submucosal-dissection-for-a-superficial-hypopharyngeal-cancer-a-case-report-and-technical-discussion
#9
Lianjun Di, Kuang-I Fu, Rui Xie, Xinglong Wu, Youfeng Li, Huichao Wu, Biguang Tuo
BACKGROUND: Adequate working space and a clear view for the dissected lesion are crucial for endoscopic submucosal dissection (ESD). Pharyngeal ESD requires that an otorhinolaryngologist creates working space by lifting the larynx with a curved laryngoscope. However, many countries do not have this kind of curved laryngoscope, and the devices could interfere with endoscope because of the narrow space of the pharynx. To overcome these issues, we used a transparent hood (Elastic Touch, slit and hole type, M (long), Top company, Tokyo Japan) instead of the curved laryngoscope to create adequate working space by pushing the larynx, and pharyngeal ESD could be done by gastroenterologists...
November 6, 2017: BMC Cancer
https://www.readbyqxmd.com/read/29110039/-endoscopic-and-surgical-treatment-of-early-gastric-and-esophageal-carcinoma
#10
REVIEW
T Haist, M Knabe, A May, D Lorenz
BACKGROUND: The treatment of early gastric (EGC) and esophageal carcinomas (EEC) is an interdisciplinary challenge. The risk of lymph node metastasis (LNM) is the crucial point in choosing the correct treatment option. OBJECTIVE: This article gives an overview of the current treatment options and provides help in choosing the correct therapy. METHOD: Current concepts and therapy algorithms are presented on the basis of a literature review and data from our own center...
November 6, 2017: Der Chirurg; Zeitschrift Für Alle Gebiete der Operativen Medizen
https://www.readbyqxmd.com/read/29104470/critical-role-of-p53-and-k-ras-in-the-diagnosis-of-early-colorectal-cancer-a-one-year-single-center-analysis
#11
Hui-Ying Lu, Ri-Tian Lin, Guang-Xi Zhou, Tian-Ming Yu, Zhan-Ju Liu
Background: Colorectal cancer (CRC) is strongly associated with colorectal polyps, which has become the third most common cancer in China. In the present study, we revealed the susceptible population and risk factors of colorectal polyps, and analyzed the expression of Ki-67, p53 and K-ras in the intestinal mucosa of patients with colorectal polyps in order to explore their significance in the detection and prognosis of CRC at an early stage. Materials and Methods: Total 801 cases of colorectal polyps were collected during endoscopic resection including endoscopic mucosal resection (EMR) and endoscopic submucosal dissection (ESD)...
2017: International Journal of Medical Sciences
https://www.readbyqxmd.com/read/29103941/asymmetry-of-an-intracellular-scaffold-at-vertebrate-electrical-synapses
#12
Audrey J Marsh, Jennifer Carlisle Michel, Anisha P Adke, Emily L Heckman, Adam C Miller
Neuronal synaptic connections are either chemical or electrical, and these two types of synapses work together to dynamically define neural circuit function [1]. Although we know a great deal about the molecules that support chemical synapse formation and function, we know little about the macromolecular complexes that regulate electrical synapses. Electrical synapses are created by gap junction (GJ) channels that provide direct ionic communication between neurons [2]. Although they are often molecularly and functionally symmetric, recent work has found that pre- and postsynaptic neurons can contribute different GJ-forming proteins, creating molecularly asymmetric channels that are correlated with functional asymmetry at the synapse [3, 4]...
October 24, 2017: Current Biology: CB
https://www.readbyqxmd.com/read/29103763/occurrence-of-metachronous-or-synchronous-lesions-after-endoscopic-treatment-of-gastric-epithelia-dysplasia-impact-of-histologic-features-of-background-mucosa
#13
Won-Young Park, So-Jeong Lee, Young-Keum Kim, Ahrong Kim, Do Youn Park, Bong-Eun Lee, Geun-Am Song, Gwang Ha Kim
AIMS: Endoscopic resection is a safe and effective method to treat gastric epithelia dysplasia (GED). However, the development of metachronous and synchronous lesions after treatment has become a major concern. In this study, we investigated clinicopathologic features of 105 GED lesions from endoscopic resections between January 2008 and December 2009. Our goal is to find histologic factors that predict synchronous and metachronous lesions after ESD treatment. We assessed the degree of intestinal metaplasia (IM) and atrophy, type of IM, presence of gastritis cystica profunda, and crypt dysplasia in the adjacent mucosa...
October 28, 2017: Pathology, Research and Practice
https://www.readbyqxmd.com/read/29099441/mastoid-and-inner-ear-measurements-in-patients-with-meni%C3%A3-re-s-disease
#14
Eric M Sugihara, Alexander L Marinica, Nathan D Vandjelovic, Benjamin M Kelley, Said S Sana, Nicholas E Starkey, Seilesh C Babu
OBJECTIVE: To determine the relationship between radiographic temporal bone anatomy of patients with Menière's disease in medically and surgically managed populations versus controls. STUDY DESIGN: Retrospective chart review. SETTING: Two tertiary referral centers. PATIENTS: Adults older than 18 years with Menière's disease treated with endolymphatic sac decompression (ESD) or medical management (non-ESD) versus controls...
December 2017: Otology & Neurotology
https://www.readbyqxmd.com/read/29098434/resection-outcomes-and-recurrence-rates-of-endoscopic-submucosal-dissection-esd-and-hybrid-esd-for-colorectal-tumors-in-a-single-italian-center
#15
Reza V Milano, Edi Viale, Michael J Bartel, Chiara Notaristefano, Pier Alberto Testoni
BACKGROUND: Endoscopic submucosal dissection (ESD) and hybrid-ESD techniques are treatment modalities for colorectal neoplasia, although mostly used in the Eastern hemisphere. Only few data on ESD for colorectal neoplasia have been published in the West. We report the outcomes of colorectal ESD and hybrid ESD in a single Italian center. METHODS: We retrospectively evaluated the outcomes of all ESD and hybrid-ESD procedures for colorectal neoplasia performed over the first 2-year experience from a prospectively recorded database...
November 2, 2017: Surgical Endoscopy
https://www.readbyqxmd.com/read/29098429/clinical-outcomes-of-deep-invasive-submucosal-colorectal-cancer-after-esd
#16
Daisuke Watanabe, Takashi Toyonaga, Makoto Ooi, Tetsuya Yoshizaki, Yoshiko Ohara, Shinwa Tanaka, Fumiaki Kawara, Tsukasa Ishida, Yoshinori Morita, Eiji Umegaki, Takeru Matsuda, Yasuo Sumi, Mari Nishio, Hiroshi Yokozaki, Takeshi Azuma
BACKGROUND AND STUDY AIMS: Endoscopic submucosal dissection (ESD) is a reliable method that can replace surgery under certain conditions. However, limited information is available on the clinical course of T1b colorectal cancer (CRC) after ESD. The aim of the study was to clarify the feasibility of ESD for T1b CRC. PATIENTS AND METHODS: Three hundred and two patients with 312 T1 CRC were identified in this retrospective cohort study. All patients were treated with ESD, other endoscopic treatments, or surgery...
November 2, 2017: Surgical Endoscopy
https://www.readbyqxmd.com/read/29094323/enormous-postoperative-perforation-after-endoscopic-submucosal-dissection-for-duodenal-cancer-successfully-treated-with-filling-and-shielding-by-polyglycolic-acid-sheets-with-fibrin-glue-and-computed-tomography-guided-abscess-puncture
#17
Yoshiko Ohara, Kengo Takimoto, Takashi Toyonaga, Tomohiro Yamaguchi, Hiroya Sakaguchi, Fumiaki Kawara, Shinwa Tanaka, Tsukasa Ishida, Yoshinori Morita, Eiji Umegaki
A female in her 70s underwent esophagogastroduodenoscopy (EGD) for screening, and a 0-IIa lesion measuring approximately 15 mm was detected in the descending portion of the duodenum. Due to the malignant potency of the lesion, endoscopic submucosal dissection (ESD) was performed. Microperforation occurred during ESD. The lesion was removed en bloc and the post-ESD ulcer bed was closed with clips. The next day, the patient had abdominal pain and computed tomography (CT) revealed a small amount of free air in the retroperitoneal space...
November 1, 2017: Clinical Journal of Gastroenterology
https://www.readbyqxmd.com/read/29084076/lymph-node-metastasis-can-be-determined-by-just-tumor-depth-and-lymphovascular-invasion-in-early-gastric-cancer-patients-after-endoscopic-submucosal-dissection
#18
Atsushi Goto, Jun Nishikawa, Eizaburou Hideura, Ryo Ogawa, Misato Nagao, Sho Sasaki, Ryo Kawasato, Shinichi Hashimoto, Takeshi Okamoto, Hiroyuki Ogihara, Yoshihiko Hamamoto, Isao Sakaida
PURPOSE: Endoscopic submucosal dissection (ESD) is a minimally invasive treatment for early gastric cancer (EGC) with negligible risk of lymph node metastasis (LNM). When a patient is determined to have noncurative resection after ESD, additional surgical resection with lymph node dissection is recommended. Previous studies report that LNM is found in about 10% of these patients. It may be possible to avoid unnecessary surgical resection by selecting patients properly. We aimed to clarify the risk factors associated with LNM in EGC patients who underwent ESD and to develop a highly accurate diagnostic algorithm for LNM...
December 2017: European Journal of Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/29084075/the-safety-and-efficacy-of-endoscopic-submucosal-dissection-for-early-gastric-cancer-with-concomitant-liver-cirrhosis
#19
Mohamed Barakat, Bhanu Singh, Carolyn Salafia, Saphwat Eskaros
OBJECTIVE/BACKGROUND: Endoscopic submucosal dissection (ESD) allows en bloc resection of lesions with R0 margins; however, it has a higher risk of bleeding and perforation compared with endoscopic mucosal resection. Surgical intervention for early gastric cancer (EGC) has been associated with an increased risk of bleeding in patients with liver cirrhosis (LC). Our aim was to assess the safety and efficacy of ESD in patients with EGC and concomitant LC. PATIENTS AND METHODS: We performed a systematic review of Medline and Cochrane database followed by a pooled data-analysis...
October 27, 2017: European Journal of Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/29083255/comparison-analysis-of-three-different-types-of-minimally-invasive-procedures-for-gastrointestinal-stromal-tumors-%C3%A2-5%C3%A2-cm
#20
Xiaonan Yin, Yuan Yin, Huijiao Chen, Chaoyong Shen, Sumin Tang, Zhaolun Cai, Bo Zhang, Zhixin Chen
OBJECTIVE: This study aimed to evaluate the safety, feasibility, and prognosis of three different types of minimally invasive procedures for treating gastric gastrointestinal stromal tumors (GISTs) ≤5 cm. MATERIALS AND METHODS: The clinical data, perioperative conditions, and the follow-up results of patients who underwent laparoscopic resection (LAP), laparoscopic and endoscopic cooperative surgery (LECS), or endoscopic submucosal dissection (ESD) for gastric GISTs ≤5 cm were retrospectively collected and analyzed...
October 30, 2017: Journal of Laparoendoscopic & Advanced Surgical Techniques. Part A
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