keyword
https://read.qxmd.com/read/38383330/autophagy-proteins-and-clinical-data-reveal-the-prognosis-of-polycystic-ovary-syndrome
#1
JOURNAL ARTICLE
Yuanyuan Wu, Jinge Huang, Cai Liu, Fang Wang
OBJECTIVE: We aimed to investigate the significance of autophagy proteins and their association with clinical data on pregnancy loss in polycystic ovary syndrome (PCOS), while also constructing predictive models. METHODS: This study was a secondary analysis. we collected endometrial samples from 33 patients with polycystic ovary syndrome (PCOS) and 7 patients with successful pregnancy control women at the Reproductive Center of the Second Hospital of Lanzhou University between September 2019 and September 2020...
February 21, 2024: BMC Pregnancy and Childbirth
https://read.qxmd.com/read/38310251/hyperinsulinemia-impairs-decidualization-via-akt-nr4a1-signaling-new-insight-into-polycystic-ovary-syndrome-pcos-related-infertility
#2
JOURNAL ARTICLE
Nan-Xing Jiang, Wei-Jie Zhao, Hao-Ran Shen, Dan-Feng Du, Xue-Lian Li
BACKGROUND: Investigating the underlying molecular mechanisms responsible for endometrial dysfunction in women with PCOS is essential, particularly focusing on the role of hyperinsulinemia. METHODS: We explored the role of insulin in the decidualization process using a synthetic decidualization assay. To dissect the effects of PI3K/AKT-NR4A signaling, we employed small interfering RNAs (siRNAs) targeting the NR4A genes and inhibitors of the PI3K/AKT pathway. We also investigated the disruption of AKT-NR4A1 signaling in the endometrium of PCOS female rats induced with dehydroepiandrosterone (DHEA)...
February 3, 2024: Journal of Ovarian Research
https://read.qxmd.com/read/38275748/differential-expression-of-insulin-growth-factor-1-igf-1-isoforms-in-different-types-of-endometriosis-preliminary-results-of-a-single-center-study
#3
JOURNAL ARTICLE
Nikolaos Blontzos, Despoina Mavrogianni, Konstantinos Ntzeros, Nikolaos Kathopoulis, Athanasios Moustogiannis, Anastassios Philippou, Michael Koutsilieris, Athanasios Protopapas
Endometriosis is a benign, estrogen-dependent gynecological condition with an uncertain exact pathogenetic mechanism. The aim of this study was to evaluate the potential differential expression of Insulin Growth Factor 1 (IGF-1) isoforms in deeply infiltrating endometriotic (DIE) lesions, in ovarian endometriomas, and in the eutopic endometrium of the same endometriosis patients and to compare their expression with that in the eutopic endometrium of women without endometriosis. A total of 39 patients were included: 28 with endometriosis, of whom 15 had endometriomas only, 7 had DIE nodules only, and 6 had both DIE and endometriomas, and 11 without endometriosis served as controls...
December 20, 2023: Biomolecules
https://read.qxmd.com/read/38256276/implantation-and-decidualization-in-pcos-unraveling-the-complexities-of-pregnancy
#4
REVIEW
Satoko Matsuyama, Sarah Whiteside, Shu-Yun Li
Polycystic Ovary Syndrome (PCOS) is a prevalent endocrine disorder in women of reproductive age, affecting 5-15% globally with a large proportion undiagnosed. This review explores the multifaceted nature of PCOS and its impact on pregnancy, including challenges in fertility due to hormonal imbalances and insulin resistance. Despite restoring ovulation pharmacologically, women with PCOS face lower pregnancy rates and higher risks of implantation failure and miscarriage. Our review focuses on the complexities of hormonal and metabolic imbalances that impair endometrial receptivity and decidualization in PCOS...
January 18, 2024: International Journal of Molecular Sciences
https://read.qxmd.com/read/38182066/camp-regulates-the-progesterone-receptor-gene-expression-through-the-protein-kinase-a-pathway-during-decidualization-in-human-immortalized-endometrial-stromal-cells
#5
JOURNAL ARTICLE
Alejandra Monserrat Retis-Resendiz, Yesenia Cid-Cruz, Dora María Velázquez-Hernández, Jessica Romero-Reyes, Moisés León-Juárez, Elizabeth García-Gómez, Ignacio Camacho-Arroyo, Edgar Ricardo Vázquez-Martínez
Decidualization, a crucial process for successful pregnancy establishment and maintenance, involves endometrial stromal cell differentiation. This process is orchestrated by estradiol (E2), progesterone, and other stimuli that increase intracellular cyclic adenosine monophosphate (cAMP) levels. The intracellular progesterone receptor (PR), encoded by the PGR gene, has a key role in decidualization. This study aimed to understand the role of sex steroids and cAMP in regulating PGR expression during the in vitro decidualization of the human immortalized endometrial stromal cell line, T-HESC...
January 3, 2024: Steroids
https://read.qxmd.com/read/38148009/polycystic-ovary-syndrome-and-adverse-pregnancy-outcomes-potential-role-of-decidual-function
#6
JOURNAL ARTICLE
Lisha Li, Hanting Ge, Jing Zhou, Jing Wang, Ling Wang
Polycystic ovary syndrome (PCOS) is a common endocrine disorder affecting fertility and mental health among women of reproductive age. In addition to anovulation and hyperandrogenism, patients also experience metabolic issues, such as insulin resistance, obesity, and dyslipidemia, as well as chronic low-grade inflammation throughout the body. Recent studies have shown that even with assisted reproductive technology to treat anovulatory issues, patients with PCOS still have higher rates of adverse pregnancy outcomes and abortion compared to normal pregnancies...
December 27, 2023: Drug Discoveries & Therapeutics
https://read.qxmd.com/read/38016376/endometrial-protein-expression-and-phosphorylation-landscape-decipher-aberrant-insulin-and-mtor-signalling-in-patients-with-recurrent-pregnancy-loss
#7
JOURNAL ARTICLE
Chao Chen, Qi Wen, Feng Deng, Rong Li, Ying Wang, Xiumei Zhen, Jing Hang
RESEARCH QUESTION: What are the proteomic and phosphoproteomic differences between the endometrium of women with recurrent pregnancy loss (RPL) and the endometrium of healthy control women during the proliferative and secretory phases of the menstrual cycle? DESIGN: In total, 54 endometrial samples were collected during the proliferative and secretory phases from women with RPL (n = 28) and healthy controls (n = 26). Comprehensive proteomic and phosphoproteomic analyses were conducted using label-free liquid chromatography-tandem mass spectrometry (n = 44), and verified through Western blotting (n = 10)...
October 1, 2023: Reproductive Biomedicine Online
https://read.qxmd.com/read/38001038/advanced-maternal-age-leads-to-changes-within-the-insulin-igf-system-and-lipid-metabolism-in-the-reproductive-tract-and-preimplantation-embryo-insights-from-the-rabbit-model
#8
JOURNAL ARTICLE
Juliane Trohl, Maria Schindler, Maximilian Buske, Johanna de Nivelle, Alicia Toto Nienguesso, Anne Navarrete Santos
Reproductive potential in women declines with age. The impact of aging on embryo-maternal interactions is still unclear. Rabbits were used as a reproductive model to investigate maternal age-related alterations in reproductive organs and embryos on day 6 of pregnancy. Blood, ovaries, endometrium, and blastocysts from young (16-20 weeks) and advanced maternal age phase (>108 weeks, old) rabbits were analysed at the mRNA and protein levels to investigate the insulin-like growth factor (IGF) system, lipid metabolism, and stress defence system...
November 24, 2023: Molecular Human Reproduction
https://read.qxmd.com/read/37993904/the-prolactin-receptor-gene-prlr-is-linked-and-associated-with-the-risk-of-polycystic-ovarian-syndrome
#9
JOURNAL ARTICLE
Mutaz Amin, Claudia Gragnoli
The prolactin receptor gene (PRLR) may contribute to polycystic ovarian syndrome (PCOS) since it plays important roles in physiological ovarian functions. PRLR-knockout mice have irregular cycles and subfertility and variants in or around the PRLR gene were associated in humans with female testosterone levels and recurrent miscarriage. We tested 40 variants in the PRLR gene in 212 Italian families phenotyped by type 2 diabetes (T2D) and PCOS and found two intronic PRLR-variants (rs13436213 and rs1604428) significantly linked to and/or associated with the risk of PCOS...
November 22, 2023: Journal of Ovarian Research
https://read.qxmd.com/read/37988160/deciphering-the-role-of-insulin-like-growth-factor-1-in-endometrial-cancer-in-patients-with-polycystic-ovary-syndrome-protocol-for-a-methodological-approach-using-cell-culture-experiments
#10
JOURNAL ARTICLE
William Atiomo, Fatma Alqutami, Sara Albasha, Mahmood Hachim
BACKGROUND: Endometrial cancer (EC) is the most common gynecological cancer in women globally. It is linked to increasing obesity rates and longer life spans. The molecular mechanisms leading to EC are unclear; however, women with polycystic ovary syndrome (PCOS) have a 3- to 5-fold increased EC risk. According to a pilot study conducted in the United Kingdom, insulin-like growth factor-1 (IGF-1) gene and protein were raised in the endometrium and blood of women with EC and PCOS, compared with those without PCOS (controls)...
November 21, 2023: JMIR Research Protocols
https://read.qxmd.com/read/37972259/dht-and-insulin-up-regulate-secretion-of-the-soluble-decoy-receptor-of-il-33-from-decidualized-endometrial-stromal-cells
#11
JOURNAL ARTICLE
Daniel Salamon, Dorina Ujvari, Anton Hellberg, Angelica Lindén Hirschberg
Interleukin 33 (IL-33) signaling regulates most of the key processes of pregnancy, including decidualization, trophoblast proliferation and invasion, vascular remodeling, and placental growth. Accordingly, dysregulation of IL-33, its membrane bound receptor (ST2L, transducer of IL-33 signaling) and its soluble decoy receptor (sST2, inhibitor of IL-33 signaling) has been linked to a wide range of adverse pregnancy outcomes that are common in women with obesity and polycystic ovary syndrome, i.e., conditions associated with hyperandrogenism, insulin resistance and compensatory hyperinsulinemia...
November 16, 2023: Endocrinology
https://read.qxmd.com/read/37879506/mechanism-of-cryptotanshinone-to-improve-endocrine-and-metabolic-functions-in-the-endometrium-of-pcos-rats
#12
JOURNAL ARTICLE
Yi-Chao Liu, Jun-Wen Wang, Jia Li, Ying Guo, Feng-Juan Han, Wei-Hong Lu, Qiong Wu
ETHNOPHARMACOLOGICAL RELEVANCE: Cryptotanshinone is the main bioactive component of Salvia miltiorrhiza, with various mechanisms of action, including antioxidant, anti-inflammatory, cardiovascular protection, neuroprotection, and hepatoprotection. Salvia miltiorrhiza is used clinically by gynecologists in China. AIM OF THE STUDY: Polycystic ovary syndrome (PCOS) has a significant impact on women's quality of life, leading to infertility and reproductive disorders...
October 23, 2023: Journal of Ethnopharmacology
https://read.qxmd.com/read/37844671/the-interplay-of-obesity-microbiome-dynamics-and-innovative-anti-obesity-strategies-in-the-context-of-endometrial-cancer-progression-and-therapeutic-approaches
#13
REVIEW
Wesley C Burkett, Angela D Clontz, Temitope O Keku, Victoria Bae-Jump
Endometrial cancer (EC) is the most common gynecologic malignancy in the United States, and its incidence and mortality are rising. Obesity is more tightly associated with EC than any other cancer. Thus, the rising prevalence of obesity and associated risk factors, including diabetes and insulin resistance, cause alarm. The metabolic derangements of obesity increase the bioavailability of estrogen, hyperinsulinemia, and inflammation in a complex system with direct and indirect effects on the endometrium, resulting in proliferation and, ultimately, carcinogenesis...
October 14, 2023: Biochimica et Biophysica Acta. Reviews on Cancer
https://read.qxmd.com/read/37831348/upregulated-rpa2-in-endometrial-tissues-of-repeated-implantation-failure-patients-impairs-the-endometrial-decidualization
#14
JOURNAL ARTICLE
Huishan Zhao, Na Lv, Jianxiang Cong, Gang Chen, Hongchu Bao, Xuemei Liu
PURPOSE: To investigate the expression and underlying mechanism of RPA2 in endometrium of patients with repeated implantation failure (RIF). METHODS: In this study, we retrieved the expression profiles from GEO databases and filtered the differentially expressed genes between RIF and the fertile control group. Ultimately, RPA2 was confirmed as a target gene. RPA2 expression in endometrial tissues of RIF patients, the control group, and different phases was detected by RT-qPCR, immunohistochemistry, and Western blotting...
October 13, 2023: Journal of Assisted Reproduction and Genetics
https://read.qxmd.com/read/37766405/western-style-diet-in-the-presence-of-elevated-circulating-testosterone-induces-adipocyte-hypertrophy-without-proinflammatory-responses-in-rhesus-macaques
#15
JOURNAL ARTICLE
Benjamin J Burwitz, Sofiya Yusova, Jacob J Robino, Diana Takahashi, Addie Luo, Ov D Slayden, Cecily V Bishop, Jon D Hennebold, Charles T Roberts, Oleg Varlamov
PROBLEM: Anovulatory infertility is commonly associated with hyperandrogenemia (elevated testosterone, T), insulin resistance, obesity, and white adipose tissue (WAT) dysfunction associated with adipocyte hypertrophy. However, whether hyperandrogenemia and adipocyte hypertrophy per se induce a proinflammatory response is unknown. METHOD OF STUDY: Young adult female rhesus macaques were exposed to an obesogenic Western-style diet (WSD) in the presence of elevated circulating testosterone (T+WSD) or a low-fat control diet with no exogenous T...
October 2023: American Journal of Reproductive Immunology: AJRI
https://read.qxmd.com/read/37569402/hyperandrogenism-and-its-possible-effects-on-endometrial-receptivity-a-review
#16
REVIEW
Allia Najmie Muhammad Yusuf, Mohd Fariz Amri, Azizah Ugusman, Adila A Hamid, Norhazlina Abdul Wahab, Mohd Helmy Mokhtar
Endometrial receptivity is a state of the endometrium defined by its readiness for embryo implantation. When the receptivity of the endometrium is impaired due to hyperandrogenism or androgen excess, this condition can lead to pregnancy loss or infertility. Hyperandrogenism encompasses a wide range of clinical manifestations, including polycystic ovary syndrome (PCOS), idiopathic hirsutism, hirsutism and hyperandrogaenemia, non-classical congenital adrenal hyperplasia, hyperandrogenism, insulin resistance, acanthosis nigricans (HAIR-AN), ovarian or adrenal androgen-secreting neoplasms, Cushing's syndrome, and hyperprolactinaemia...
July 27, 2023: International Journal of Molecular Sciences
https://read.qxmd.com/read/37555382/triglyceride-glucose-index-tyg-index-and-endometrial-carcinoma-risk-a-retrospective-cohort-study
#17
JOURNAL ARTICLE
Haimeng Shi, Feifei Guo, Kang Zheng, Rong Li, Huaijun Zhou
OBJECTIVE: We analyzed the association between the triglyceride-glucose index (TyG index) and incident endometrial carcinogenesis, aiming to determine whether the TyG index is a promising predictive biomarker for endometrial carcinoma (EC). METHODS: In this retrospective cohort study, multiple logistic regression analysis was performed to evaluate the relationship between TyG index and EC incidence and progression. The receiver operating characteristic (ROC) curve was used to calculate the area under the curve (AUC), as well as the cut-off value of the TyG index for EC incidence...
August 9, 2023: International Journal of Gynaecology and Obstetrics
https://read.qxmd.com/read/37533344/hif-1%C3%AE-is-positively-associated-with-endometrial-receptivity-by-regulating-pkm2
#18
JOURNAL ARTICLE
Lixia Liang, Yang Yang, Lin Yang, Xiuping Zhang, Suming Xu, Yanling Liu, Xueqing Wu, Lan Chao
PURPOSE: Numerous advancements have been introduced into the field of assisted reproductive technology (ART) in the past four decades. Nonetheless, implantation failure is still a key limiting step for a successful pregnancy. Building of endometrial receptivity (ER) is essential for successful implantation. However, the fundamental biological processes and mechanisms of ER remain elusive. Our study investigates the function of hypoxia inducible factor-1α (HIF-1α) during ER establishment and shed lights on the novel molecular mechanism by which HIF-1α regulates ER-related gene expression network...
August 2, 2023: Journal of Obstetrics and Gynaecology Research
https://read.qxmd.com/read/37395213/talin1-regulates-glucose-metabolism-and-endometrial-receptivity-via-glut-4-in-patients-with-polycystic-ovary-syndrome-and-insulin-resistance
#19
JOURNAL ARTICLE
Jingjing Li, Saiqiong Chen, Rongyan Qin, Xin Liu, Li Fan, Mengjun Wei, Jiajia Wei, Jiajing Lin, Fengque Zheng
Objectives : Talin1 is a cytoskeletal protein and is localized between cells and the extracellular matrix. This study aimed to investigate the mechanism by which Talin1 affects glucose metabolism and endometrial receptivity via glucose transporter proteins-4 (GLUT-4) in patients with polycystic ovary syndrome (PCOS) and insulin resistance (IR). Methods: We examined the expression of Talin1 and GLUT4 in the receptive endometrium of PCOS-IR and control patients. GLUT4 expression was examined after silencing and overexpression of Talin1 in Ishikawa cells...
December 2023: Gynecological Endocrinology
https://read.qxmd.com/read/37373229/d-chiro-inositol-in-endometrial-hyperplasia-a-pilot-study
#20
JOURNAL ARTICLE
Giuseppina Porcaro, Gabriele Bilotta, Elena Capoccia, Maria Salomé Bezerra Espinola, Cesare Aragona
Endometrial hyperplasia is a threatening pathology driven by unopposed estrogen stimulus. Moreover, insulin may act on the endometrium, prompting further growth. We aimed at assessing whether D-chiro-Inositol, an insulin sensitizer with estrogen-lowering properties, might improve the condition of patients with simple endometrial hyperplasia without atypia. We enrolled women with simple endometrial hyperplasia without atypia and related symptoms, including abnormal uterine bleeding. We treated the patients with one tablet per day, containing 600 mg of D-chiro-inositol for six months...
June 13, 2023: International Journal of Molecular Sciences
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