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https://www.readbyqxmd.com/read/27935261/matrix-rigidity-regulates-the-microtubule-network-polarization-in-migration
#1
Matthew Raab, Dennis E Discher
The microtubule organizing center (MTOC) frequently polarizes to a position in front of the nucleus during cell migration, but recent work has shown conflicting evidence for the MTOC location in migratory polarized cells. Here, we show that subcellular localization of the MTOC is modulated by the extracellular matrix stiffness. Specifically, we found that ECM compliance alters the positioning of the MTOC during cell migration in scratch wound assays as well as single cell migration of mesenchymal stem cells (MSCs)...
December 9, 2016: Cytoskeleton
https://www.readbyqxmd.com/read/27934187/3d-printed-microfluidic-device-with-microporous-mn2o3-modified-screen-printed-electrode-for-real-time-determination-of-heavy-metal-ions
#2
Ying Hong, Meiyan Wu, Guangwei Chen, Ziyang Dai, Yizhou Zhang, Guosong Chen, Xiaochen Dong
Fabricating portable devices for the determination of heavy metal ions is an ongoing challenge. Here, a 3D printing approach was adopted to fabricate a microfluidic electrochemical sensor with the desired shape in which the model for velocity profiles in microfluidic cells was built and optimized by the finite element method (FEM). The electrode in the microfluidic cell was a flexible screen-printed electrode (SPE) modified with porous Mn2O3 derived from manganese containing metal-organic framework (Mn-MOF)...
December 7, 2016: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/27933765/3d-printing-of-hierarchical-silk-fibroin-structures
#3
Marianne R Sommer, Manuel Schaffner, Davide Carnelli, André R Studart
Like many other natural materials, silk is hierarchically structured from the amino acid level up to the cocoon or spider web macroscopic structures. Despite being used industrially in a number of applications, hierarchically structured silk fibroin objects with a similar degree of architectural control as in natural structures have not been produced yet due to limitations in fabrication processes. In a combined top-down and bottom-up approach, we exploit the freedom in macroscopic design offered by 3D printing and the template-guided assembly of ink building blocks at the meso- and nanolevel to fabricate hierarchical silk porous materials with unprecedented structural control...
December 9, 2016: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/27928774/a-3d-printed-anatomical-pancreas-and-kidney-phantom-for-optimizing-spect-ct-reconstruction-settings-in-beta-cell-imaging-using-111-in-exendin
#4
Wietske Woliner-van der Weg, Laura N Deden, Antoi P W Meeuwis, Maaike Koenrades, Laura H C Peeters, Henny Kuipers, Geert Jan Laanstra, Martin Gotthardt, Cornelis H Slump, Eric P Visser
BACKGROUND: Quantitative single photon emission computed tomography (SPECT) is challenging, especially for pancreatic beta cell imaging with (111)In-exendin due to high uptake in the kidneys versus much lower uptake in the nearby pancreas. Therefore, we designed a three-dimensionally (3D) printed phantom representing the pancreas and kidneys to mimic the human situation in beta cell imaging. The phantom was used to assess the effect of different reconstruction settings on the quantification of the pancreas uptake for two different, commercially available software packages...
December 2016: EJNMMI Physics
https://www.readbyqxmd.com/read/27928031/multi-casting-approach-for-vascular-networks-in-cellularized-hydrogels
#5
Alexander W Justin, Roger A Brooks, Athina E Markaki
Vascularization is essential for living tissue and remains a major challenge in the field of tissue engineering. A lack of a perfusable channel network within a large and densely populated tissue engineered construct leads to necrotic core formation, preventing fabrication of functional tissues and organs. We report a new method for producing a hierarchical, three-dimensional (3D) and perfusable vasculature in a large, cellularized fibrin hydrogel. Bifurcating channels, varying in size from 1 mm to 200-250 µm, are formed using a novel process in which we convert a 3D printed thermoplastic material into a gelatin network template, by way of an intermediate alginate hydrogel...
December 2016: Journal of the Royal Society, Interface
https://www.readbyqxmd.com/read/27925094/technology-for-self-care-for-ostomized-women-s-sexual-and-reproductive-health
#6
Andressa Ferreira Leite Ladislau Albuquerque, Ana Karina Bezerra Pinheiro, Francisca Márcia Pereira Linhares, Tatiane Gomes Guedes
Objective: to validate the technology of printed booklets on self-care for ostomized women's sexual and reproductive health. Method: a methodological study was performed with a focus on the construction and validity of a printed booklet. The content of this booklet was validated by 11 specialist judges/nurses, according to a Content Validity Index (CVI) equal to or higher than 0.80. Appearance was validated by nine ostomized women, according to an assessment of the difficulty and convenience of the educational material...
November 2016: Revista Brasileira de Enfermagem
https://www.readbyqxmd.com/read/27922094/foldable-and-disposable-memory-on-paper
#7
Byung-Hyun Lee, Dong-Il Lee, Hagyoul Bae, Hyejeong Seong, Seung-Bae Jeon, Myung-Lok Seol, Jin-Woo Han, M Meyyappan, Sung-Gap Im, Yang-Kyu Choi
Foldable organic memory on cellulose nanofibril paper with bendable and rollable characteristics is demonstrated by employing initiated chemical vapor deposition (iCVD) for polymerization of the resistive switching layer and inkjet printing of the electrode, where iCVD based on all-dry and room temperature process is very suitable for paper electronics. This memory exhibits a low operation voltage of 1.5 V enabling battery operation compared to previous reports and wide memory window. The memory performance is maintained after folding tests, showing high endurance...
December 6, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27917703/principles-of-the-kenzan-method-for-robotic-cell-spheroid-based-3d-bioprinting
#8
Nicanor I Moldovan, Narutoshi Hibino, Koichi Nakayama
Bioprinting is a technology with the prospect to change the way many diseases are treated, by replacing the damaged tissues with live, de novo created bio-similar constructs. However, after more than a decade of incubation and many proofs-of-concept, the field is still in its infancy. The current stagnation is the consequence of its early success: the first bioprinters, and most of those which followed, were modified versions of the 3D printers used in additive manufacturing, redesigned for layer-by-layer dispersion of biomaterials...
December 4, 2016: Tissue Engineering. Part B, Reviews
https://www.readbyqxmd.com/read/27914987/tetrabromobisphenol-a-activates-the-hepatic-interferon-pathway-in-rats
#9
J K Dunnick, D L Morgan, S A Elmore, K Gerrish, A Pandiri, T V Ton, K R Shockley, B A Merrick
Tetrabromobisphenol A (TBBPA) is a widely used flame retardant in printed circuit boards, paper, and textiles. In a two-year study, TBBPA showed evidence of uterine tumors in female Wistar-Han rats and liver and colon tumors in B6C3F1 mice. In order to gain further insight into early gene and pathway changes leading to cancer, we exposed female Wistar Han rats to TBBPA at 0, 25, 250, or 1000mg/kg (oral gavage in corn oil, 5X/week) for 13 weeks. Because at the end of the TBBPA exposure period, there were no treatment-related effects on body weights, liver or uterus lesions, and liver and uterine organ weights were within 10% of controls, only the high dose animals were analyzed...
November 30, 2016: Toxicology Letters
https://www.readbyqxmd.com/read/27898010/applications-of-alginate-based-bioinks-in-3d-bioprinting
#10
REVIEW
Eneko Axpe, Michelle L Oyen
Three-dimensional (3D) bioprinting is on the cusp of permitting the direct fabrication of artificial living tissue. Multicellular building blocks (bioinks) are dispensed layer by layer and scaled for the target construct. However, only a few materials are able to fulfill the considerable requirements for suitable bioink formulation, a critical component of efficient 3D bioprinting. Alginate, a naturally occurring polysaccharide, is clearly the most commonly employed material in current bioinks. Here, we discuss the benefits and disadvantages of the use of alginate in 3D bioprinting by summarizing the most recent studies that used alginate for printing vascular tissue, bone and cartilage...
November 25, 2016: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/27878922/a-nodd-like-protein-activates-transcription-of-genes-involved-with-naringenin-degradation-in-a-flavonoid-dependent-manner-in-herbaspirillum-seropedicae
#11
R Wassem, A M Marin, A Daddaoua, R A Monteiro, L S Chubatsu, J L Ramos, W J Deakin, W J Broughton, F O Pedrosa, E M Souza
Herbaspirillum seropedicae is an associative, endophytic non-nodulating diazotrophic bacterium that colonises several grasses. An ORF encoding a LysR-type transcriptional regulator, very similar to NodD proteins of rhizobia, was identified in its genome. This nodD-like gene, named fdeR, is divergently transcribed from an operon encoding enzymes involved in flavonoid degradation (fde operon). Apigenin, chrysin, luteolin and naringenin strongly induce transcription of the fde operon, but not that of the fdeR, in an FdeR-dependent manner...
November 23, 2016: Environmental Microbiology
https://www.readbyqxmd.com/read/27875647/what-pacemakers-can-teach-us-about-the-ethics-of-maintaining-artificial-organs
#12
Katrina Hutchison, Robert Sparrow
One day soon it may be possible to replace a failing heart, liver, or kidney with a long-lasting mechanical replacement or perhaps even with a 3-D printed version based on the patient's own tissue. Such artificial organs could make transplant waiting lists and immunosuppression a thing of the past. Supposing that this happens, what will the ongoing care of people with these implants involve? In particular, how will the need to maintain the functioning of artificial organs over an extended period affect patients and their doctors and the responsibilities of those who manufacture such devices? Drawing on lessons from the history of the cardiac pacemaker, this article offers an initial survey of the ethical issues posed by the need to maintain and service artificial organs...
November 2016: Hastings Center Report
https://www.readbyqxmd.com/read/27874001/spray-printing-of-organic-semiconducting-single-crystals
#13
Grigorios-Panagiotis Rigas, Marcia M Payne, John E Anthony, Peter N Horton, Fernando A Castro, Maxim Shkunov
Single-crystal semiconductors have been at the forefront of scientific interest for more than 70 years, serving as the backbone of electronic devices. Inorganic single crystals are typically grown from a melt using time-consuming and energy-intensive processes. Organic semiconductor single crystals, however, can be grown using solution-based methods at room temperature in air, opening up the possibility of large-scale production of inexpensive electronics targeting applications ranging from field-effect transistors and light-emitting diodes to medical X-ray detectors...
November 22, 2016: Nature Communications
https://www.readbyqxmd.com/read/27854532/twitter-as-a-tool-for-health-research-a-systematic-review
#14
Lauren Sinnenberg, Alison M Buttenheim, Kevin Padrez, Christina Mancheno, Lyle Ungar, Raina M Merchant
BACKGROUND: Researchers have used traditional databases to study public health for decades. Less is known about the use of social media data sources, such as Twitter, for this purpose. OBJECTIVES: To systematically review the use of Twitter in health research, define a taxonomy to describe Twitter use, and characterize the current state of Twitter in health research. SEARCH METHODS: We performed a literature search in PubMed, Embase, Web of Science, Google Scholar, and CINAHL through September 2015...
January 2017: American Journal of Public Health
https://www.readbyqxmd.com/read/27854522/evidence-and-health-policy-using-and-regulating-systematic-reviews
#15
Daniel M Fox
Systematic reviews have, increasingly, informed policy for almost 3 decades. In many countries, systematic reviews have informed policy for public and population health, paying for health care, increasing the quality and efficiency of interventions, and improving the effectiveness of health sector professionals and the organizations in which they work. Systematic reviews also inform other policy areas: criminal justice, education, social welfare, and the regulation of toxins in the environment. Although the production and use of systematic reviews has steadily increased, many clinicians, public health officials, representatives of commercial organizations, and, consequently, policymakers who are responsive to them, have been reluctant to use these reviews to inform policy; others have actively opposed using them...
January 2017: American Journal of Public Health
https://www.readbyqxmd.com/read/27854518/the-university-public-health-partnership-for-public-health-research-training-in-quebec-canada
#16
Gilles Paradis, Anne-Marie Hamelin, Maureen Malowany, Joseph Levy, Michel Rossignol, Pierre Bergeron, Natalie Kishchuk
Enhancing effective preventive interventions to address contemporary public health problems requires improved capacity for applied public health research. A particular need has been recognized for capacity development in population health intervention research to address the complex multidisciplinary challenges of developing, implementing, and evaluating public health practices, intervention programs, and policies. Research training programs need to adapt to these new realities. We have presented an example of a 2003 to 2015 training program in transdisciplinary research on public health interventions that embedded doctoral and postdoctoral trainees in public health organizations in Quebec, Canada...
January 2017: American Journal of Public Health
https://www.readbyqxmd.com/read/27852763/adaptation-to-life-in-aeolian-sand-how-the-sandfish-lizard-scincus-scincus-prevents-sand-particles-from-entering-its-lungs
#17
Anna T Stadler, Boštjan Vihar, Mathias Günther, Michaela Huemer, Martin Riedl, Stephanie Shamiyeh, Bernhard Mayrhofer, Wolfgang Böhme, Werner Baumgartner
The sandfish lizard, Scincus scincus (Squamata: Scincidae), spends nearly its whole life in aeolian sand and only comes to the surface for foraging, defecating and mating. It is not yet understood how the animal can respire without sand particles entering its respiratory organs when buried under thick layers of sand. In this work, we integrated biological studies, computational calculations and physical experiments to understand this phenomenon. We present a 3D model of the upper respiratory system based on a detailed histological analysis...
November 15, 2016: Journal of Experimental Biology
https://www.readbyqxmd.com/read/27845796/paper-microchip-with-a-graphene-modified-silver-nano-composite-electrode-for-electrical-sensing-of-microbial-pathogens
#18
Mohammadali Safavieh, Vivasvat Kaul, Sultan Khetani, Anupriya Singh, Karan Dhingra, Manoj Kumar Kanakasabapathy, Mohamed Shehata Draz, Adnan Memic, Daniel R Kuritzkes, Hadi Shafiee
Rapid and sensitive point-of-care diagnostics are of paramount importance for early detection of infectious diseases and timely initiation of treatment. Here, we present cellulose paper and flexible plastic chips with printed graphene-modified silver electrodes as universal point-of-care diagnostic tools for the rapid and sensitive detection of microbial pathogens or nucleic acids through utilizing electrical sensing modality and loop-mediated isothermal amplification (LAMP). We evaluated the ability of the developed paper-based assay to detect (i) viruses on cellulose-based paper microchips without implementing amplification in samples with viral loads between 10(6) and 10(8) copies per ml, and (ii) amplified HIV-1 nucleic acids in samples with viral loads between 10 fg μl(-1) and 10(8) fg μl(-1)...
November 15, 2016: Nanoscale
https://www.readbyqxmd.com/read/27844174/designing-3-dimensional-in-vitro-oviduct-culture-systems-to-study-mammalian-fertilization-and-embryo-production
#19
Marcia A M M Ferraz, Heiko H W Henning, Tom A E Stout, Peter L A M Vos, Bart M Gadella
The oviduct was long considered a largely passive conduit for gametes and embryos. However, an increasing number of studies into oviduct physiology have demonstrated that it specifically and significantly influences gamete interaction, fertilization and early embryo development. While oviduct epithelial cell (OEC) function has been examined during maintenance in conventional tissue culture dishes, cells seeded into these two-dimensional (2-D) conditions suffer a rapid loss of differentiated OEC characteristics, such as ciliation and secretory activity...
November 14, 2016: Annals of Biomedical Engineering
https://www.readbyqxmd.com/read/27833916/patterning-of-endothelial-cells-and-mesenchymal-stem-cells-by-laser-assisted-bioprinting-to-study-cell-migration
#20
Jean-Michel Bourget, Olivia Kérourédan, Manuela Medina, Murielle Rémy, Noélie Brunehilde Thébaud, Reine Bareille, Olivier Chassande, Joëlle Amédée, Sylvain Catros, Raphaël Devillard
Tissue engineering of large organs is currently limited by the lack of potent vascularization in vitro. Tissue-engineered bone grafts can be prevascularized in vitro using endothelial cells (ECs). The microvascular network architecture could be controlled by printing ECs following a specific pattern. Using laser-assisted bioprinting, we investigated the effect of distance between printed cell islets and the influence of coprinted mesenchymal cells on migration. When printed alone, ECs spread out evenly on the collagen hydrogel, regardless of the distance between cell islets...
2016: BioMed Research International
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