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https://www.readbyqxmd.com/read/28529670/perspective-fabrication-of-integrated-organ-on-a-chip-via-bioprinting
#1
Qingzhen Yang, Qin Lian, Feng Xu
Organ-on-a-chip has emerged as a powerful platform with widespread applications in biomedical engineering, such as pathology studies and drug screening. However, the fabrication of organ-on-a-chip is still a challenging task due to its complexity. For an integrated organ-on-a-chip, it may contain four key elements, i.e., a microfluidic chip, live cells/microtissues that are cultured in this chip, components for stimulus loading to mature the microtissues, and sensors for results readout. Recently, bioprinting has been used for fabricating organ-on-a-chip as it enables the printing of multiple materials, including biocompatible materials and even live cells in a programmable manner with a high spatial resolution...
May 2017: Biomicrofluidics
https://www.readbyqxmd.com/read/28524743/nanoparticle-exposures-from-nano-enabled-toner-based-printing-equipment-and-human-health-state-of-science-and-future-research-needs
#2
Sandra Vanessa Pirela, John Martin, Dhimiter Bello, Philip Demokritou
Toner formulations used by laser printers (LP) and photocopiers (PC), collectively called "toner-based printing equipment" (TPE), are nano-enabled products (NEP) because they contain several engineered nanomaterials (ENM) that improve toner performance. It has been shown that during consumer use (printing), these ENM are released in the air, together with other semi-volatile organic nanoparticles, and newly formed gaseous co-pollutants such as volatile organic compounds (VOC). The aim of this review is to detail and analyze physico-chemical and morphological (PCM), as well as the toxicological properties of particulate matter (PM) emissions from TPE...
May 19, 2017: Critical Reviews in Toxicology
https://www.readbyqxmd.com/read/28508468/visible-light-responsive-color-switching-driven-by-photocatalytic-self-doped-sno2-x-nanocrystals
#3
Dan Han, Baolai Jiang, Ji Feng, Yadong Yin, Wenshou Wang
Visible light-responsive reversible color switching systems are attractive to many applications since visible light has superior penetration and causes far less damages to organic molecules than UV. Here we report that self-doping of Sn2+ in SnO2-x nanocrystals red shifts their absorption to visible region and simultaneously produces oxygen vacancies, which can effectively scavenge photogenerated holes and thus enable color switching of redox dyes using visible light. Wavelength selective switching can also be achieved by coupling the photocatalytic activity of the SnO2-x NCs with the color switching kinetics of different redox dyes...
May 16, 2017: Angewandte Chemie
https://www.readbyqxmd.com/read/28508071/self-assembled-micro-organogels-for-3d-printing-silicone-structures
#4
Christopher S O'Bryan, Tapomoy Bhattacharjee, Samuel Hart, Christopher P Kabb, Kyle D Schulze, Indrasena Chilakala, Brent S Sumerlin, W Gregory Sawyer, Thomas E Angelini
The widespread prevalence of commercial products made from microgels illustrates the immense practical value of harnessing the jamming transition; there are countless ways to use soft, solid materials that fluidize and become solid again with small variations in applied stress. The traditional routes of microgel synthesis produce materials that predominantly swell in aqueous solvents or, less often, in aggressive organic solvents, constraining ways that these exceptionally useful materials can be used. For example, aqueous microgels have been used as the foundation of three-dimensional (3D) bioprinting applications, yet the incompatibility of available microgels with nonpolar liquids, such as oils, limits their use in 3D printing with oil-based materials, such as silicone...
May 2017: Science Advances
https://www.readbyqxmd.com/read/28505403/prediction-of-the-wetting-behavior-of-active-and-hole-transport-layers-for-printed-flexible-electronic-devices-using-molecular-dynamics-simulations
#5
Rahul Bhowmik, Rajiv J Berry, Michael F Durstock, Benjamin J Leever
Molecular dynamics (MD) simulations were used to predict the wetting behavior of materials typical of active and hole-transport layers in organic electronics by evaluating their contact angles and adhesion energies. The active layer (AL) here consists of a blend of poly(3-hexylthiophene) and phenyl-C61-butyric acid methyl ester (P3HT:PCBM), whereas the hole-transport layer (HTL) consists of a blend of poly(3,4-ethylenedioxythiophene) and poly(styrene sulfonate) (PEDOT:PSS). Simulations of the wetting of these surfaces by multiple solvents show that formamide, glycerol, and water droplet contact angle trends correlate with experimental values...
May 15, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28504512/fully-printable-organic-and-perovskite-solar-cells-with-transfer-printed-flexible-electrodes
#6
Xianqiang Li, Xiaohong Tang, Tao Ye, Dan Wu, Hong Wang, Xizu Wang
The perovskite solar cells (PSCs) and organic solar cells (OSCs) with high performance were fabricated with transfer-printed top metal electrodes. We have demonstrated that PSCs and OSCs with the top Au electrodes fabricated by using the transfer printing method have comparable or better performance than the devices with the top Au electrodes fabricated by using the conventional thermal evaporation method. The highest PCE of the PSCs and OSCs with the top electrodes fabricated using the transfer printing method achieved 13...
May 22, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28500466/a-three-dimensional-pelvic-model-made-with-a-three-dimensional-printer-applications-for-laparoscopic-surgery-to-treat-rectal-cancer
#7
A Hamabe, M Ito
To help understand the three-dimensional (3D) spatial relationships among the highly complex structures of the pelvis, we made a novel 3D pelvic model with a 3D printing system. We created two pelvic models including the muscles, vessels, nerves, and urogenital organs; the first based on the pelvic anatomy of a healthy male volunteer and the second on the pelvic anatomy of a female volunteer with rectal cancer. The models clearly demonstrated the complicated spatial relationships between anatomical structures in the pelvis...
May 12, 2017: Techniques in Coloproctology
https://www.readbyqxmd.com/read/28496134/inkjet-printing-of-nio-films-and-integration-as-hole-transporting-layers-in-polymer-solar-cells
#8
Arjun Singh, Shailendra Kumar Gupta, Ashish Garg
Stability concerns of organic solar cell devices have led to the development of alternative hole transporting layers such as NiO which lead to superior device life times over conventional Poly(3,4-ethylenedioxythiophene) Polystyrene sulfonate (PEDOT:PSS) buffered solar cells. From the printability of such devices, it is imperative to be able to print NiO layers in the organic solar cell devices with normal architecture which has so far remained unreported. In this manuscript, we report on the successful ink-jet printing of very thin NiO thin films with controlled thickness and morphology and their integration in organic solar cell devices...
May 11, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28495033/clinical-applications-of-3-dimensional-printing-in-radiation-therapy
#9
Yizhou Zhao, Kathryn Moran, Mammo Yewondwossen, James Allan, Scott Clarke, Murali Rajaraman, Derek Wilke, Paul Joseph, James L Robar
Three-dimensional (3D) printing is suitable for the fabrication of complex radiotherapy bolus. Although investigated from dosimetric and feasibility standpoints, there are few reports to date of its use for actual patient treatment. This study illustrates the versatile applications of 3D printing in clinical radiation oncology through a selection of patient cases, namely, to create bolus for photon and modulated electron radiotherapy (MERT), as well as applicators for surface high-dose rate (HDR) brachytherapy...
May 8, 2017: Medical Dosimetry: Official Journal of the American Association of Medical Dosimetrists
https://www.readbyqxmd.com/read/28486746/collagen-density-gradient-on-3d-printed-poly-%C3%AE%C2%B5-caprolactone-scaffolds-for-interface-tissue-engineering
#10
Ugo D'Amora, Matteo D'Este, David Eglin, Fatemeh Safari, Christoph M Sprecher, Antonio Gloria, Roberto De Santis, Mauro Alini, Luigi Ambrosio
The ability to engineer scaffolds which resemble the transition between tissues would be beneficial to improve repair of complex organs, but has yet to be achieved. In order to mimic tissue organization, such constructs should present continuous gradients of geometry, stiffness and biochemical composition. Although the introduction of rapid prototyping or additive manufacturing techniques allows deposition of heterogeneous layers and shape control, the creation of surface chemical gradients has not been explored on 3D scaffolds obtained through fused deposition modeling (FDM) technique...
May 9, 2017: Journal of Tissue Engineering and Regenerative Medicine
https://www.readbyqxmd.com/read/28475739/a-step-by-step-development-of-real-size-chest-model-for-simulation-of-thoracoscopic-surgery
#11
Toshiaki Morikawa, Makoto Yamashita, Makoto Odaka, Yo Tsukamoto, Takamasa Shibasaki, Shohei Mori, Hisatoshi Asano, Tadashi Akiba
OBJECTIVES: For the purpose of simulating thoracoscopic surgery, we have conducted stepwise development of a life-like chest model including thorax and intrathoracic organs. METHODS: First, CT data of the human chest were obtained. First-generation model: based on the CT data, each component of the chest was made from a 3D printer. A hard resin was used for the bony thorax and a rubber-like resin for the vessels and bronchi. Lung parenchyma, muscles and skin were not created...
May 4, 2017: Interactive Cardiovascular and Thoracic Surgery
https://www.readbyqxmd.com/read/28472175/characterization-of-3d-printing-techniques-toward-patient-specific-quality-assurance-spine-shaped-phantom-for-stereotactic-body-radiation-therapy
#12
Min-Joo Kim, Seu-Ran Lee, Min-Young Lee, Jason W Sohn, Hyong Geon Yun, Joon Yong Choi, Sang Won Jeon, Tae Suk Suh
Development and comparison of spine-shaped phantoms generated by two different 3D-printing technologies, digital light processing (DLP) and Polyjet has been purposed to utilize in patient-specific quality assurance (QA) of stereotactic body radiation treatment. The developed 3D-printed spine QA phantom consisted of an acrylic body phantom and a 3D-printed spine shaped object. DLP and Polyjet 3D printers using a high-density acrylic polymer were employed to produce spine-shaped phantoms based on CT images. Image fusion was performed to evaluate the reproducibility of our phantom, and the Hounsfield units (HUs) were measured based on each CT image...
2017: PloS One
https://www.readbyqxmd.com/read/28471308/fabrication-of-orientation-controlled-3d-tissues-using-a-layer-by-layer-technique-and-3d-printed-a-thermo-responsive-gel-frame
#13
Yoshinari Tsukamoto, Takami Akagi, Fumiaki Shima, Mitsuru Akashi
Herein, we report the fabrication of orientation-controlled tissues similar to heart and nerve tissues using a cell accumulation and three-dimensional (3D) printing technique. We firstly evaluated the 3D shaping ability of hydroxybutyl chitosan (HBC), a thermo-responsive polymer, by using a robotic dispensing 3D printer. HBC polymer could be laminated to a height of 1,124 ± 14 μm. Based on this result, we fabricated 3D gel frames of various shapes such as square, triangular, rectangular and circular for shape control of 3D tissue and then normal human cardiac fibroblasts (NHCFs) coated with extracellular matrix (ECM) nanofilms were seeded in the frames...
May 4, 2017: Tissue Engineering. Part C, Methods
https://www.readbyqxmd.com/read/28466635/thermoelectric-properties-of-highly-conductive-poly-3-4-ethylenedioxythiophene-polystyrene-sulfonate-printed-thin-films
#14
Davide Beretta, Alex J Barker, Isis Maqueira-Albo, Alberto Calloni, Gianlorenzo Bussetti, Giorgio Dell'Erba, Alessandro Luzio, Lamberto Duò, Annamaria Petrozza, Guglielmo Lanzani, Mario Caironi
Organic conductors are being evaluated for potential use in waste heat recovery through lightweight and flexible thermoelectric generators manufactured by means of cost effective printing processes. Assessment of the potentiality of organic materials in real devices still requires a deeper understanding of the physics behind their thermoelectric properties, which can pave the way towards further development of the field. This contribution reports a detailed thermoelectric study of a set of highly conducting inkjet printed films of commercially available poly(3,4-ethylenedioxythiophene) polystyrene sulfonate formulations characterized by in-plane electrical conductivity spanning the interval 10-500 S/cm ...
May 3, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28466301/comparative-metabolomic-studies-of-alkanivorax-xenomutans-showing-differential-power-output-in-a-three-chambered-microbial-fuel-cell
#15
Ganesh Mahidhara, Sasikala Ch, Venkata Ramana Ch
Metabolomic study of electrogenic bacteria is a necessity to understand the extent of complex organic matter degradation and to invent new co-culture techniques to achieve complete degradation. In this study, we have subjected Alkanivorax xenomutans (KCTC 23751(T); NBRC 108843(T)), a bacterium capable for biodegradation of complex hydrocarbons, to oxic and anoxic conditions in a three chambered microbial fuel cell. In an attempt to understand the molecular mechanisms during the electrogenic processes of A. xenomutans, intra cellular (endo metabolome or the fingerprint) and exo metabolome (extracellular metabolome or the foot print) were analyzed under oxic and anoxic conditions, using FTIR and GC-MS...
June 2017: World Journal of Microbiology & Biotechnology
https://www.readbyqxmd.com/read/28445488/a-versatile-method-for-dynamically-controlled-patterning-of-small-populations-of-epithelial-cells-on-substrates-via-non-contact-piezoelectric-inkjet-printing
#16
Kristen B Lee, Laimonas Kelbauskas, Alan Brunner, Deirdre R Meldrum
Intercellular interactions play a central role at the tissue and whole organism level modulating key cellular functions in normal and disease states. Studies of cell-cell communications are challenging due to ensemble averaging effects brought about by intrinsic heterogeneity in cellular function which requires such studies to be conducted with small populations of cells. Most of the current methods for producing and studying such small cell populations are complex to implement and require skilled personnel limiting their widespread utility in biomedical research labs...
2017: PloS One
https://www.readbyqxmd.com/read/28441950/development-of-a-web-based-patient-decision-aid-for-initiating-disease-modifying-anti-rheumatic-drugs-using-user-centred-design-methods
#17
Ingrid Nota, Constance H C Drossaert, Heleen C Melissant, Erik Taal, Harald E Vonkeman, Cees J Haagsma, Mart A F J van de Laar
BACKGROUND: A main element of patient-centred care, Patient Decision Aids (PtDAs) facilitate shared decision-making (SDM). A recent update of the International Patient Decision Aids Standards (IPDAS) emphasised patient involvement during PtDA development, but omitted a methodology for doing so. This article reports on the value of user-centred design (UCD) methods for the development of a PtDA that aims to support inflammatory arthritis patients in their choice between disease modifying anti-rheumatic drugs (DMARDs)...
April 26, 2017: BMC Medical Informatics and Decision Making
https://www.readbyqxmd.com/read/28440728/characterization-of-chemical-contaminants-generated-by-a-desktop-fused-deposition-modeling-3-dimensional-printer
#18
Aleksandr B Stefaniak, Ryan F LeBouf, Jinghai Yi, Jason Ham, Timothy Nurkewicz, Diane E Schwegler-Berry, Bean T Chen, J Raymond Wells, Matthew G Duling, Robert B Lawrence, Stephen B Martin, Alyson R Johnson, M Abbas Virji
Printing devices are known to emit chemicals into the indoor atmosphere. Understanding factors that influence release of chemical contaminants from printers is necessary to develop effective exposure assessment and control strategies. In this study, a desktop fused deposition modeling (FDM) 3-D printer using acrylonitrile butadiene styrene (ABS) or polylactic acid (PLA) filaments and two monochrome laser printers were evaluated in a 0.5 m(3) chamber. During printing, chamber air was monitored for vapors using a real-time photoionization detector (results expressed as isobutylene equivalents) to measure total volatile organic compound (TVOC) concentrations, evacuated canisters to identify specific VOCs by off-line gas chromatography-mass spectrometry (GC-MS) analysis, and liquid bubblers to identify carbonyl compounds by GC-MS...
April 25, 2017: Journal of Occupational and Environmental Hygiene
https://www.readbyqxmd.com/read/28437213/current-status-and-challenges-of-three-dimensional-modeling-and-printing-of-tissues-and-organs
#19
Syed Rafat Husain, Yoshikazu Ohya, Raj K Puri
No abstract text is available yet for this article.
February 16, 2017: Tissue Engineering. Part A
https://www.readbyqxmd.com/read/28433241/mechanics-of-additively-manufactured-biomaterials
#20
EDITORIAL
Amir A Zadpoor
Additive manufacturing (3D printing) has found many applications in healthcare including fabrication of biomaterials as well as bioprinting of tissues and organs. Additively manufactured (AM) biomaterials may possess arbitrarily complex micro-architectures that give rise to novel mechanical, physical, and biological properties. The mechanical behavior of such porous biomaterials including their quasi-static mechanical properties and fatigue resistance is not yet well understood. It is particularly important to understand the relationship between the designed micro-architecture (topology) and the resulting mechanical properties...
June 2017: Journal of the Mechanical Behavior of Biomedical Materials
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