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https://www.readbyqxmd.com/read/29346769/switching-on-depression-and-potentiation-in-the-cerebellum
#1
Andrew R Gallimore, Taegon Kim, Keiko Tanaka-Yamamoto, Erik De Schutter
Long-term depression (LTD) and long-term potentiation (LTP) in the cerebellum are important for motor learning. However, the signaling mechanisms controlling whether LTD or LTP is induced in response to synaptic stimulation remain obscure. Using a unified model of LTD and LTP at the cerebellar parallel fiber-Purkinje cell (PF-PC) synapse, we delineate the coordinated pre- and postsynaptic signaling that determines the direction of plasticity. We show that LTP is the default response to PF stimulation above a well-defined frequency threshold...
January 16, 2018: Cell Reports
https://www.readbyqxmd.com/read/29345314/the-prevalence-and-distribution-of-sheep-scab-in-wales-a-farmer-questionnaire-survey
#2
C-A Chivers, H Rose Vineer, R Wall
Outbreaks of ovine psoroptic mange in the U.K. have increased 100-fold since its deregulation in 1992, with the highest prevalence in Wales, a region of high sheep density. A cross-sectional, retrospective, questionnaire-based survey of 7500 members of the association of Welsh lamb and beef farmers [Welsh Lamb and Beef Producers Ltd (WLBP)] was used to investigate the prevalence and distribution of sheep scab in this region in 2015. The survey was completed by 14.0% (n = 972) of potential respondents. Scab outbreaks were reported on 15...
January 18, 2018: Medical and Veterinary Entomology
https://www.readbyqxmd.com/read/29345213/matcha-green-tea-drinks-enhance-fat-oxidation-during-brisk-walking-in-females
#3
Mark Elisabeth Theodorus Willems, Mehmet Akif Şahin, Matthew David Cook
Intake of the catechin epigallocatechin gallate and caffeine has been shown to enhance exercise-induced fat oxidation. Matcha green tea powder contains catechins and caffeine and is consumed as a drink. We examined the effect of Matcha green tea drinks on metabolic, physiological and perceived intensity responses during brisk walking. Thirteen females (age: 27±8 yr, body mass: 65±7 kg, height: 166±6 cm) volunteered. Resting metabolic equivalent (1-MET) was measured using Douglas bags (1-MET: 3.4±0.3 ml·kg-1·min-1)...
January 18, 2018: International Journal of Sport Nutrition and Exercise Metabolism
https://www.readbyqxmd.com/read/29345088/retraction
#4
(no author information available yet)
'The association of hypotension with the insertion of an abdominal retractor during lower abdominal surgery in pediatric patients: a retrospective observational study' by Rika Nakayama, Takahiro Mihara, Yoshihisa Miyamoto & Koui Ka.1 The above article from Pediatric Anesthesia, published online on July 7, 2015 in Wiley Online Library (http://wileyonlinelibrary.com) has been retracted by agreement between the authors, the Journal Editor in Chief, Andrew Davidson, and John Wiley & Sons Ltd. The retraction has been agreed following a review of the study data by the authors, which found that cases not satisfying the inclusion criteria were included and that there were data collection errors with respect to the patients' ages and sexes...
February 2018: Paediatric Anaesthesia
https://www.readbyqxmd.com/read/29344794/ticagrelor-for-secondary-prevention-of-atherothrombotic-events-after-myocardial-infarction-an-evidence-review-group-perspective-of-a-nice-single-technology-appraisal
#5
REVIEW
Xavier G L V Pouwels, Robert Wolff, Bram L T Ramaekers, Anoukh Van Giessen, Shona Lang, Steve Ryder, Gill Worthy, Steven Duffy, Nigel Armstrong, Jos Kleijnen, Manuela A Joore
The National Institute for Health and Care Excellence (NICE) invited AstraZeneca, the manufacturer of ticagrelor (Brilique®), to submit evidence on the clinical and cost effectiveness of ticagrelor 60 mg twice daily (BID) in combination with low-dose aspirin [acetylsalicylic acid (ASA)] compared with ASA only for secondary prevention of atherothrombotic events in patients with a history of myocardial infarction (MI) and who are at increased risk of atherothrombotic events. Kleijnen Systematic Reviews Ltd (KSR), in collaboration with Maastricht University Medical Centre+, was commissioned as the evidence review group (ERG)...
January 18, 2018: PharmacoEconomics
https://www.readbyqxmd.com/read/29338287/book-review-out-of-the-woods-a-journey-through-depression-and-anxiety-out-of-the-woods-a-journey-through-depression-and-anxiety-williams-brent-educational-resources-ltd-new-edition-2017-isbn-10-047339006x-isbn-13-978-0473390068
#6
Ben Beaglehole
No abstract text is available yet for this article.
January 1, 2018: Australasian Psychiatry: Bulletin of Royal Australian and New Zealand College of Psychiatrists
https://www.readbyqxmd.com/read/29336086/learning-to-blast-a-way-into-crime-or-just-good-clean-fun-examining-aggressive-play-with-toy-weapons-and-its-relation-with-crime
#7
Sven Smith, Christopher J Ferguson, Kevin M Beaver
BACKGROUND: Researchers, such as Bandura, have proposed that children's mere exposure to the use of play weapons encourages deviant displays of aggression, but there is very little research to support this hypothesis of 20 years. AIM: To examine the relationship between amount of weapon play and concurrent aggression as well as later violent juvenile crime, while controlling for other variables possibly influencing criminal pathways. METHOD: Using longitudinal survey data collected from mothers and children (n = 2019) from age 5, with follow-up at age 15, correlations between children's play with toy weapons and juvenile criminality were examined...
January 16, 2018: Criminal Behaviour and Mental Health: CBMH
https://www.readbyqxmd.com/read/29336084/age-onset-of-offending-and-serious-mental-illness-among-forensic-psychiatric-patients-a-latent-profile-analysis
#8
Stephanie R Penney, Aaron Prosser, Alexander I F Simpson
BACKGROUND: Developmental typologies regarding age of onset of violence and offending have not routinely taken account of the role of serious mental illness (SMI), and whether age of onset of offending in relation to onset of illness impacts on the manifestation of offending over the life course. AIMS: To test whether forensic psychiatric patients can be classified according to age of onset of SMI and offending, and, if so, whether subtypes differ by sex. METHODS: Details of all 511 patients enrolled into a large forensic mental health service in Ontario, Canada, in 2011 or 2012 were collected from records...
January 16, 2018: Criminal Behaviour and Mental Health: CBMH
https://www.readbyqxmd.com/read/29336082/metabolomics-study-of-cultivated-bulbus-fritillariae-cirrhosae-at-different-growth-stages-using-uhplc-qtof-ms-coupled-with-multivariate-data-analysis
#9
Zhao Geng, YiFei Liu, Yan Gou, QinMei Zhou, ChengJun He, Li Guo, Juan Zhou, Liang Xiong
INTRODUCTION: Bulbus fritillariae cirrhosae (known as Chuān bèi mǔ in China, BFC) contain fritillaria steroidal alkaloids as the bioactive ingredients and are widely used as traditional Chinese medicine for the treatment of cough and phlegm. Due to limited wild resources, the cultivated species are becoming predominantly used in Chinese traditional medicine markets. OBJECTIVE: To assess the impact of different growth stages on the alkaloids of cultivated BFC and establish a reference for quality control and guidance for appropriate harvesting practices...
January 15, 2018: Phytochemical Analysis: PCA
https://www.readbyqxmd.com/read/29336069/an-examination-of-the-interaction-between-morality-and-self-control-in-offending-a-study-of-differences-between-girls-and-boys
#10
Anna-Karin Ivert, Frida Andersson, Robert Svensson, Lieven J R Pauwels, Marie Torstensson Levander
BACKGROUND: There is a well-documented gender difference in offending, with evidence that boys, on average, are more involved in crime than girls. Opinions differ, however, on whether the causes of crime apply to girls and boys similarly. AIMS: Our aim is to explore crime propensity in boys and girls. Our research questions were (1) are there differences between boys and girls in moral values and self-control; (2) are these attributes similarly correlated with offending among girls and boys; and (3) is any interaction effect between morality and self-control identical for girls and boys...
January 16, 2018: Criminal Behaviour and Mental Health: CBMH
https://www.readbyqxmd.com/read/29334164/clinical-evaluation-of-a-novel-fractional-radiofrequency-device-for-hair-growth-fractional-radiofrequency-for-hair-growth-stimulation
#11
Ines Verner, Torello Lotti
AGA is a common disorder. Different treatments are available to prevent hair loss and achieve hair growth with variable results. The purpose of the present study was to evaluate the efficacy and safety of a novel fractional radiofrequency (RF) device (HairLux, Innogen Technologies Ltd., Yokneam, Israel), to prevent hair loss and induce hair growth. Twenty-five patients received 10 fractional RF treatments every 2 weeks, and were followed up 2 months after the last treatment. All patients were evaluated by global photography...
January 15, 2018: Dermatologic Therapy
https://www.readbyqxmd.com/read/29332654/evaluation-of-loop-mediated-isothermal-amplification-lamp-assay-in-the-diagnosis-of-tubercular-lymphadenitis-a-pilot-study
#12
Baijayantimala Mishra, Vinaykumar Hallur, Bijayini Behera, C Preetam, Priti Nanda Mishra, Jyotirmayee Turuk, Prasanta Raghab Mohapatra
Tubercular lymphadenitis (TBLA) contributes to 30-40% of extrapulmonary TB cases in the immunocompetent individuals and 40-50% in people with HIV. Current diagnostic methods for TBLA like Gene-Xpert or PCR are costly and conventional methods like fine needle aspiration cytology, histopathology lack sensitivity and specificity. Culture which is considered as gold standard require high turnaround time. Loop mediated isothermal amplification (LAMP) assay has been developed as a novel technique for nucleic acid amplification and has shown promising results in the diagnosis of pulmonary tuberculosis...
January 2018: Indian Journal of Tuberculosis
https://www.readbyqxmd.com/read/29330858/long-term-outcomes-of-cochlear-implantation-in-patients-with-high-frequency-hearing-loss
#13
J Thomas Roland, Bruce J Gantz, Susan B Waltzman, Aaron J Parkinson
OBJECTIVE: To demonstrate the long-term benefits of implantation in patients with high-frequency sensorineural hearing loss, this report provides 5-year follow-up on a group of implant recipients who were subjects of the Cochlear™ Nucleus® Hybrid™ L24 Implant System pivotal clinical study. METHODS: The results of three related clinical studies were compiled to provide outcome data after 1, 3, and 5 years of implant use in a group of subjects who presented with preoperative high-frequency hearing loss and were implanted with a Nucleus Hybrid L24 (Cochlear Ltd...
January 13, 2018: Laryngoscope
https://www.readbyqxmd.com/read/29323417/loss-of-ethanol-inhibition-of-nmdar-mediated-currents-and-plasticity-of-cerebellar-synapses-in-mice-expressing-the-glun1-f639a-subunit
#14
Paula A Zamudio-Bulcock, Gregg E Homanics, John J Woodward
BACKGROUND: Glutamatergic N-methyl-D-aspartate receptors (NMDARs) are well known for their sensitivity to ethanol inhibition. However, the specific manner in which ethanol inhibits channel activity and how such inhibition affects neurotransmission, and ultimately behavior, remain unclear. Replacement of phenylalanine 639 with alanine (F639A) in the GluN1 subunit reduces ethanol inhibition of recombinant NMDA receptors. Mice expressing this subunit show reduced ethanol-induced anxiolysis, blunted locomotor stimulation following low dose ethanol administration and faster recovery of motor function after moderate doses of ethanol suggesting that cerebellar dysfunction may contribute to some of these behaviors...
January 11, 2018: Alcoholism, Clinical and Experimental Research
https://www.readbyqxmd.com/read/29322255/-electronic-vision-aids-new-options-for-rehabilitation-of-the-visually-impaired
#15
REVIEW
N Celik, K Rohrschneider
Due to technical advances, there has been an enormous improvement of electronic vision aids in recent years. New developments are especially small portable devices which can be easily carried. The majority of electronic vision aids serve as a reading aid. Electronic magnifiers are a portable alternative to conventional screen readers. In addition, there are mobile reading devices and special computer tools. Color recognition devices and barcode scanners are helpful in everyday life. Ultrasonic orientation systems enable the recognition of obstacles also at head height...
January 10, 2018: Der Ophthalmologe: Zeitschrift der Deutschen Ophthalmologischen Gesellschaft
https://www.readbyqxmd.com/read/29322024/hypocalcaemia-and-permanent-hypoparathyroidism-after-total-bilateral-thyroidectomy-in-the-baets-registry
#16
REVIEW
David R Chadwick
The UK Registry of Endocrine and Thyroid Surgeons (UKRETS) has been operated by the British Association of Endocrine and Thyroid Surgeons (BAETS) and Dendrite Clinical Systems Ltd. in a web-based electronic format since 2004. Data on over 90,000 endocrine procedures have been collected to date. Analysis of those cases undergoing bilateral thyroid resections in the interval July 2010 to June 2015 demonstrates that hypocalcaemia remains the commonest complication of thyroid surgery. After first-time total thyroidectomy, 23...
December 2017: Gland Surgery
https://www.readbyqxmd.com/read/29320590/treatment-of-d%C3%A3-colletage-photoaging-with-fractional-microneedling-radiofrequency
#17
Alexis Lyons, Jillian Roy, Jennifer Herrmann, Lisa Chipps
OBJECTIVES: The objective of this study was to examine the efficacy and safety of a novel fractional microneedling radiofrequency device to improve the appearance of rhytides and skin laxity of the décolletage. METHODS: Twelve subjects received a total of three fractional microneedling radiofrequency treatments with Endymed Intensif (EndyMed Ltd., Cesarea, Israel) at least three weeks apart. Primary outcome measure was clinical efficacy quantified by a patient survey to assess treatment satisfaction as well as a physician Global Aesthetic Improvement Scale (GAIS)...
January 1, 2018: Journal of Drugs in Dermatology: JDD
https://www.readbyqxmd.com/read/29318715/comparative-evaluation-of-skin-moisture-after-topical-application-of-10-and-30-lactobionic-acid
#18
Barbara Algiert-Zielińska, Paulina Mucha, Helena Rotsztejn
BACKGROUND: Dry skin is characterized by symptoms such as itching, redness, excessive exfoliation. These symptoms cause discomfort and contribute to secondary bacterial infections. Dry skin treatments are based on topical applications of various formulations. Among many of them are polyhydroxy acids, which recently gained more attention. AIMS: The aim of this study was a comparative assessment of hydration level (corneometric) after application of lactobionic acid (LA) in the form of peel at concentrations of 10% and 30%...
January 9, 2018: Journal of Cosmetic Dermatology
https://www.readbyqxmd.com/read/29318711/risk-factors-for-eating-disorder-psychopathology-within-the-treatment-seeking-transgender-population-the-role-of-cross-sex-hormone-treatment
#19
Bethany Alice Jones, Emma Haycraft, Walter Pierre Bouman, Nicola Brewin, Laurence Claes, Jon Arcelus
Many transgender people experience high levels of body dissatisfaction, which is one of the numerous factors known to increase vulnerability to eating disorder symptoms in the cisgender (non-trans) population. Cross-sex hormones can alleviate body dissatisfaction so might also alleviate eating disorder symptoms. This study aimed to explore risk factors for eating disorder symptoms in transgender people and the role of cross-sex hormones. Individuals assessed at a national transgender health service were invited to participate (N = 563)...
January 10, 2018: European Eating Disorders Review: the Journal of the Eating Disorders Association
https://www.readbyqxmd.com/read/29317910/impact-of-choice-of-skin-preparation-solution-in-cardiac-surgery-on-rate-of-surgical-site-infection-a-propensity-score-matched-analysis
#20
Shahzad G Raja, Melissa Rochon, Clair Mullins, Carlos Morais, Antonios Kourliouros, Ellie Wishart, Anthony De Souza, Sunil Bhudia
Background: Antiseptic skin preparations containing chlorhexidine gluconate and povidone iodine are routinely used to reduce the risk of surgical site infection (SSI). This study assesses the efficacy of two alcohol-based solutions, 2% chlorhexidine-alcohol and 10% povidone iodine-alcohol, on the incidence of cardiac SSI. Methods: A total of 738 consecutive patients undergoing cardiac surgery had skin preparation with 2% chlorhexidine gluconate in 70% isopropanol (ChloraPrep, BD Ltd, UK) were propensity matched to 738 patients with skin prepared with 10% povidone-iodine in 30% industrial methylated spirit (Videne Alcoholic Tincture, Ecolab Ltd, UK)...
January 2018: Journal of Infection Prevention
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