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https://www.readbyqxmd.com/read/28544668/intolerance-of-uncertainty-in-eating-disorders-a-systematic-review-and-meta-analysis
#1
REVIEW
Melanie Brown, Lauren Robinson, Giovanna Cristina Campione, Kelsey Wuensch, Tom Hildebrandt, Nadia Micali
Intolerance of uncertainty is an empirically supported transdiagnostic construct that may have relevance in understanding eating disorders. We conducted a meta-analysis and systematic review of intolerance of uncertainty in eating disorders using Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. We calculated random-effects standardised mean differences (SMD) for studies utilising the Intolerance of Uncertainty Scale (IUS) and summarised additional studies descriptively...
May 23, 2017: European Eating Disorders Review: the Journal of the Eating Disorders Association
https://www.readbyqxmd.com/read/28544496/suicide-attempts-and-self-injurious-behaviours-in-adolescent-and-adult-patients-with-borderline-personality-disorder
#2
Marianne Goodman, Irene Alvarez Tomas, Christina M Temes, Garrett M Fitzmaurice, Blaise A Aguirre, Mary C Zanarini
OBJECTIVE: Prevalence data on self-mutilation and suicide attempts for adolescent borderline personality disorder (BPD) are currently not available. The purpose of this paper was to determine the frequency and methods of two forms of physically self-destructive acts (i.e. self-mutilation and suicide attempts) reported by adolescent borderline inpatients in one of the largest samples to date and to compare these results with a similarly diagnosed and assessed group of adult borderline inpatients...
May 22, 2017: Personality and Mental Health
https://www.readbyqxmd.com/read/28544385/korean-red-ginseng-extract-enhances-the-anticancer-effects-of-sorafenib-through-abrogation-of-creb-and-c-jun-activation-in-renal-cell-carcinoma
#3
Chulwon Kim, Jong Hyun Lee, Seung Ho Baek, Jeong-Hyeon Ko, Dongwoo Nam, Kwang Seok Ahn
Although application of sorafenib in the treatment of human renal cell carcinoma (RCC) remains one of the best examples of successful targeted therapy, majority of RCC patients suffer from its side effects as well as develop resistance to this targeted therapy. Thus, there is a need to promote novel alternative therapies for the treatment of RCC. In this study, we investigated whether Korean red ginseng extract (KRGE) could inhibit the proliferation and induce chemosensitization in human renal cancer cells...
May 22, 2017: Phytotherapy Research: PTR
https://www.readbyqxmd.com/read/28544187/chemical-composition-and-immuno-modulatory-effects-of-urtica-dioica-l-stinging-nettle-extracts
#4
Marina Francišković, Raquel Gonzalez-Pérez, Dejan Orčić, Fermín Sánchez de Medina, Olga Martínez-Augustin, Emilija Svirčev, Nataša Simin, Neda Mimica-Dukić
The purpose of this work was to determine the chemical profile of stinging nettle and to provide an insight into the mechanisms by which it ameliorates the immune response. Qualitative and quantitative liquid chromatography tandem mass spectrometry analyses indicated that phenolic acids (5-O-caffeoylquinic acid as dominant) and flavonol glycosides (rutin, isoquercitrin, and kaempferol 3-O-glucoside) are present in the aerial parts, while lignans (secoisolariciresinol, 9,9'-bisacetyl-neo-olivil and their glucosides) were detected in the root...
May 24, 2017: Phytotherapy Research: PTR
https://www.readbyqxmd.com/read/28544134/depression-and-cognitive-impairment-among-newly-admitted-nursing-home-residents-in-the-usa
#5
Christine M Ulbricht, Anthony J Rothschild, Jacob N Hunnicutt, Kate L Lapane
OBJECTIVE: The objective of this study is to describe the prevalence of depression and cognitive impairment among newly admitted nursing home residents in the USA and to describe the treatment of depression by level of cognitive impairment. METHODS: We identified 1,088,619 newly admitted older residents between 2011 and 2013 with an active diagnosis of depression documented on the Minimum Data Set 3.0. The prevalence of receiving psychiatric treatment was estimated by cognitive impairment status and depression symptoms...
May 23, 2017: International Journal of Geriatric Psychiatry
https://www.readbyqxmd.com/read/28544038/supplementation-with-herbal-extracts-to-promote-behavioral-and-neuroprotective-effects-in-experimental-models-of-parkinson-s-disease-a-systematic-review
#6
REVIEW
Ianara Mendonça da Costa, José Rodolfo Lopes de Paiva Cavalcanti, Dinalva Brito de Queiroz, Eduardo Pereira de Azevedo, Amália Cinthia Meneses do Rêgo, Irami Araújo Filho, Paulo Parente, Marco Antônio Botelho, Fausto Pierdoná Guzen
Parkinson's disease (PD) consists of a neurodegenerative pathology that has received a considerable amount of attention because of its clinical manifestations. The most common treatment consists of administering the drugs levodopa and biperiden, which reduce the effectiveness of the disease and the progress of its symptoms. However, phytotherapy treatment of PD has shown great potential in retarding the loss of dopaminergic neurons and minimizing the behavioral abnormalities. The aim of this study is to systematically review the use of supplemental herbal plants with cellular protective effect and behavioral activity in in vivo and in vitro experimental models...
May 22, 2017: Phytotherapy Research: PTR
https://www.readbyqxmd.com/read/28543910/wheatgrass-derived-polysaccharide-has-antiinflammatory-anti-oxidative-and-anti-apoptotic-effects-on-lps-induced-hepatic-injury-in-mice
#7
Sarmila Nepali, Hyeon-Hui Ki, Ji-Hyun Lee, Hoon-Yeon Lee, Dae-Ki Kim, Young-Mi Lee
Hepatic injury occurs frequently during sepsis, and polysaccharides isolated from plants have been reported to have antiinflammatory and antioxidant effects in various models. However, the effect of wheatgrass-derived polysaccharide (WGP) has not been previously studied. In the present study, we investigated the effect of WGP on lipopolysaccharide (LPS)-induced hepatic injury in mice. Mice were pre-treated with WGP (100 or 200 mg/kg daily for 2 days) and then challenged with LPS (1 mg/kg, intraperitoneal), and sacrificed after 12 h...
May 24, 2017: Phytotherapy Research: PTR
https://www.readbyqxmd.com/read/28543848/non-animal-assessment-of-skin-sensitization-hazard-is-an-integrated-testing-strategy-needed-and-if-so-what-should-be-integrated
#8
REVIEW
David W Roberts, Grace Patlewicz
There is an expectation that to meet regulatory requirements, and avoid or minimize animal testing, integrated approaches to testing and assessment will be needed that rely on assays representing key events (KEs) in the skin sensitization adverse outcome pathway. Three non-animal assays have been formally validated and regulatory adopted: the direct peptide reactivity assay (DPRA), the KeratinoSens™ assay and the human cell line activation test (h-CLAT). There have been many efforts to develop integrated approaches to testing and assessment with the "two out of three" approach attracting much attention...
May 24, 2017: Journal of Applied Toxicology: JAT
https://www.readbyqxmd.com/read/28543807/aromatic-interaction-mediated-inhibition-of-%C3%AE-amyloid-assembly-structures-and-cytotoxicity
#9
Hanyi Xie, Jiaxi Peng, Changliang Liu, Xiaocui Fang, Hongyang Duan, Yimin Zou, Yanlian Yang, Chen Wang
Abnormal aggregation of β-amyloid (Aβ) peptide plays an important role in the onset and progress of Alzheimer's disease (AD); hence, targeting Aβ aggregation is considered as an effective therapeutic strategy. Here, we studied the aromatic-interaction-mediated inhibitory effect of oligomeric polypeptides (K8Y8, K4Y8, K8W8) on Aβ42 fibrillization process. The polypeptides containing lysine as well as representative aromatic amino acids of tryptophan or tyrosine were found to greatly suppress the aggregation as evaluated by thioflavin T assay...
May 23, 2017: Journal of Peptide Science: An Official Publication of the European Peptide Society
https://www.readbyqxmd.com/read/28543801/characterisation-of-pomegranate-husk-polyphenols-and-semi-preparative-fractionation-of-punicalagin
#10
Pedro Aguilar-Zárate, Jorge E Wong-Paz, Mariela Michel, Juan Buenrostro-Figueroa, Hugo R Díaz, Juan A Ascacio, Juan C Contreras-Esquivel, Gerardo Gutiérrez-Sánchez, Cristóbal N Aguilar
INTRODUCTION: Pomegranate-husk is the main by-product generated from the pomegranate industry. It is a potential source of compounds highly appreciated by different costumers. Punicalagin is the main compound present in pomegranate-husk. OBJECTIVE: To characterise the pomegranate-husk total polyphenols by HPLC-ESI-MS and to establish a method for the recovery of punicalagin using a medium pressure liquid chromatography (MPLC) system. MATERIALS AND METHODS: The characterisation of total pomegranate-husk polyphenols was carried out using liquid chromatography coupled to mass spectrometry...
May 23, 2017: Phytochemical Analysis: PCA
https://www.readbyqxmd.com/read/28543732/joint-hypermobility-is-also-associated-with-anxiety-disorders-in-the-elderly-population
#11
Andrea Bulbena-Cabré, Conxita Rojo, Guillem Pailhez, Emma Buron Maso, Luis Miguel Martín-Lopez, Antonio Bulbena
BACKGROUND: Anxiety disorders (AD) are very prevalent in the elderly, tend to compromise quality of life, and generate substantial costs. Considering that the prevention and early detection of anxiety may be relevant to increase health gains in older adults, it would be of great interest to identify whether the joint hypermobility syndrome (JHS) is also related to anxiety disorders in this age range. METHODS: Cross-sectional data was collected in a sample of 108 subjects in a rural town in Spain...
May 23, 2017: International Journal of Geriatric Psychiatry
https://www.readbyqxmd.com/read/28543719/the-role-of-self-serving-cognitive-distortions-in-reactive-and-proactive-aggression
#12
Sanne Oostermeijer, Kirsten C Smeets, Lucres M C Jansen, Tijs Jambroes, Nanda N J Rommelse, Floor E Scheepers, Jan K Buitelaar, Arne Popma
BACKGROUND: Aggression is often divided into reactive and proactive forms. Reactive aggression is typically thought to encompass 'blaming others' and 'assuming the worst', while proactive aggression relates to 'self-centeredness' and 'minimising/mislabelling'. AIM: Our aim was to evaluate relationships between reactive and proactive aggression and cognitive distortions and to test whether changes in these cognitions relate to changes in aggression. METHODS: A total of 151 adolescents (60% boys; mean age 15...
May 24, 2017: Criminal Behaviour and Mental Health: CBMH
https://www.readbyqxmd.com/read/28543626/smooth-semi-nonparametric-snp-estimation-of-the-cumulative-incidence-function
#13
Anh Nguyen Duc, Marcel Wolbers
This paper presents a novel approach to estimation of the cumulative incidence function in the presence of competing risks. The underlying statistical model is specified via a mixture factorization of the joint distribution of the event type and the time to the event. The time to event distributions conditional on the event type are modeled using smooth semi-nonparametric densities. One strength of this approach is that it can handle arbitrary censoring and truncation while relying on mild parametric assumptions...
May 23, 2017: Statistics in Medicine
https://www.readbyqxmd.com/read/28543585/a-score-test-for-genetic-class-level-association-with-nonlinear-biomarker-trajectories
#14
Jing Qian, Sara Nunez, Soohyun Kim, Muredach P Reilly, Andrea S Foulkes
Emerging data suggest that the genetic regulation of the biological response to inflammatory stress may be fundamentally different to the genetic underpinning of the homeostatic control (resting state) of the same biological measures. In this paper, we interrogate this hypothesis using a single-SNP score test and a novel class-level testing strategy to characterize protein-coding gene and regulatory element-level associations with longitudinal biomarker trajectories in response to stimulus. Using the proposed class-level association score statistic for longitudinal data, which accounts for correlations induced by linkage disequilibrium, the genetic underpinnings of evoked dynamic changes in repeatedly measured biomarkers are investigated...
May 23, 2017: Statistics in Medicine
https://www.readbyqxmd.com/read/28543517/intermediate-and-advanced-topics-in-multilevel-logistic-regression-analysis
#15
Peter C Austin, Juan Merlo
Multilevel data occur frequently in health services, population and public health, and epidemiologic research. In such research, binary outcomes are common. Multilevel logistic regression models allow one to account for the clustering of subjects within clusters of higher-level units when estimating the effect of subject and cluster characteristics on subject outcomes. A search of the PubMed database demonstrated that the use of multilevel or hierarchical regression models is increasing rapidly. However, our impression is that many analysts simply use multilevel regression models to account for the nuisance of within-cluster homogeneity that is induced by clustering...
May 23, 2017: Statistics in Medicine
https://www.readbyqxmd.com/read/28543407/assessing-bipolar-disorder-in-the-older-adult-the-geri-bd-toolbox
#16
Patricia Marino, Herbert C Schulberg, Ariel G Gildengers, Benoit H Mulsant, Martha Sajatovic, Laszlo Gyulai, Rayan K Aljurdi, Laurie Davan Evans, Samprit Banerjee, Ruben C Gur, Robert C Young
INTRODUCTION: The evidence base regarding characteristics of older adults with bipolar disorder (BD) remains limited. The NIH-funded multicenter study Acute Pharmacotherapy of Late-Life Mania (GERI-BD) assessed various clinical domains before and during mood stabilizer treatment in older adults participating in a 9-week, double-blind randomized controlled trial. We describe the rationale for selecting these instruments. METHODS: Domains and instruments were selected on the basis of the study design and the participants...
May 22, 2017: International Journal of Geriatric Psychiatry
https://www.readbyqxmd.com/read/28543307/a-bayesian-approach-to-model-the-conditional-correlation-between-several-diagnostic-tests-and-various-replicated-subjects-measurements
#17
Hélio Doyle Pereira da Silva, Carlos Ascaso, Alessandra Queiroga Gonçalves, Patricia Puccinelli Orlandi, Rosa Abellana
Two key aims of diagnostic research are to accurately and precisely estimate disease prevalence and test sensitivity and specificity. Latent class models have been proposed that consider the correlation between subject measures determined by different tests in order to diagnose diseases for which gold standard tests are not available. In some clinical studies, several measures of the same subject are made with the same test under the same conditions (replicated measurements), and thus, replicated measurements for each subject are not independent...
May 21, 2017: Statistics in Medicine
https://www.readbyqxmd.com/read/28543214/the-forecasting-of-menstruation-based-on-a-state-space-modeling-of-basal-body-temperature-time-series
#18
Keiichi Fukaya, Ai Kawamori, Yutaka Osada, Masumi Kitazawa, Makio Ishiguro
Women's basal body temperature (BBT) shows a periodic pattern that associates with menstrual cycle. Although this fact suggests a possibility that daily BBT time series can be useful for estimating the underlying phase state as well as for predicting the length of current menstrual cycle, little attention has been paid to model BBT time series. In this study, we propose a state-space model that involves the menstrual phase as a latent state variable to explain the daily fluctuation of BBT and the menstruation cycle length...
May 22, 2017: Statistics in Medicine
https://www.readbyqxmd.com/read/28543094/mechanism-of-graphene-induced-cytotoxicity-role-of-endonucleases
#19
Tariq Fahmi, La Donna Branch, Zeid A Nima, Dae Song Jang, Alena V Savenka, Alexandru S Biris, Alexei G Basnakian
Graphene, a crystalline allotrope or carbon, presents numerous useful properties; however, its toxicity is yet to be determined. One of the most dramatic and irreversible toxic abilities of carbon nanomaterials is the induction of DNA fragmentation produced by endogenous cellular endonucleases. This study demonstrated that pristine graphene exposed to cultured kidney tubular epithelial cells is capable of inducing DNA fragmentation measured by terminal deoxynucleotidyl transferase dUTP nick end labeling (TUNEL) assay, which is usually associated with cell death...
May 24, 2017: Journal of Applied Toxicology: JAT
https://www.readbyqxmd.com/read/28541054/review-of-teas-cocoa-and-coffee-plant-secondary-metabolites-and-health-teas-cocoa-and-coffee-plant-secondary-metabolites-and-health-edited-by-alan-crozier-hiroshi-ashihara-and-francisco-tom%C3%A3-s-barb%C3%A3-ran-john-wiley-sons-ltd-west-sussex-uk-2011-x-252-pp-228-18
#20
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