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https://www.readbyqxmd.com/read/29156538/combined-effects-of-simulated-microgravity-and-radiation-exposure-on-osteoclast-cell-fusion
#1
Srinivasan Shanmugarajan, Ye Zhang, Maria Moreno-Villanueva, Ryan Clanton, Larry H Rohde, Govindarajan T Ramesh, Jean D Sibonga, Honglu Wu
The loss of bone mass and alteration in bone physiology during space flight are one of the major health risks for astronauts. Although the lack of weight bearing in microgravity is considered a risk factor for bone loss and possible osteoporosis, organisms living in space are also exposed to cosmic radiation and other environmental stress factors. As such, it is still unclear as to whether and by how much radiation exposure contributes to bone loss during space travel, and whether the effects of microgravity and radiation exposure are additive or synergistic...
November 18, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29156444/survival-of-microbes-in-earth-s-stratosphere
#2
REVIEW
Priya DasSarma, Shiladitya DasSarma
The remarkable survival of microorganisms high above the surface of the Earth is of increasing interest. At stratospheric levels, multiple stressors including ultraviolet and ionizing radiation, low temperatures, hypobaric conditions, extreme desiccation, and nutrient scarcity are all significant challenges. Our understanding of which microorganisms are capable of tolerating such stressful conditions has been addressed by stratospheric sample collection and survival assays, through launching and recovery, and exposure to simulated conditions in the laboratory...
November 17, 2017: Current Opinion in Microbiology
https://www.readbyqxmd.com/read/29156345/the-extended-production-of-uv-induced-reactive-oxygen-species-in-l929-fibroblasts-is-attenuated-by-posttreatment-with-arrabidaea-chica-through-scavenging-mechanisms
#3
Fabianne Martins Ribeiro, Hélito Volpato, Danielle Lazarin-Bidóia, Vânia Cristina Desoti, Rebeca Oliveira de Souza, Maria José Vieira Fonseca, Tânia Ueda-Nakamura, Celso Vataru Nakamura, Sueli de Oliveira Silva
Ultraviolet radiation (UVR) exposure causes various injurious effects to human skin by generating reactive oxygen species (ROS). Excessive ROS production can lead to oxidative stress which may damage cellular components like lipids and proteins and causing photoaging. The use of natural photochemopreventive agents with antioxidant properties is an important alternative to improve the effectiveness of sunscreens and reduce skin photodamage. A crude extract (CE) from the leaves of Arrabidaea chica underwent partition by a liquid-liquid method...
November 17, 2017: Journal of Photochemistry and Photobiology. B, Biology
https://www.readbyqxmd.com/read/29156273/contribution-of-sun-exposure-to-the-vitamin-d-dose-received-by-various-groups-of-the-spanish-population
#4
Maria-Antonia Serrano
Although the harmful effects of excessive exposure to solar ultraviolet (UV) radiation are well known, the recommended dose of UV radiation is beneficial for the synthesis of vitamin D by the skin, in addition to being useful in the treatment of various illnesses and mental problems. Numerous studies have shown that vitamin D performs important functions in the human organism, such as absorbing calcium and phosphorous and contributing to the immune system, among others. Several studies have found that a high percentage of various groups of the Spanish population suffer from vitamin D deficiency, and since very few natural foods contain vitamin D, it was considered important to determine whether groups such as schoolchildren, outdoor workers and athletes, receive enough solar radiation to produce adequate levels of vitamin D in their daily activities...
November 17, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/29155344/freehand-technique-for-c2-pedicle-and-pars-screw-placement-safe-or-not
#5
Prachya Punyarat, K Daniel Riew, Benjamin T Klawson, Colleen Peters, Thamrong Lertudomphonwanit, Jacob M Buchowski
BACKGROUND CONTEXT: During placement of C2 pedicle and pars screws, intraoperative fluoroscopy is used so that neurovascular complications can be avoided, and screws can be placed in the proper position. However, this method is time consuming and increases radiation exposure. Furthermore, it does not guarantee completely safe and accurate screw placement. PURPOSE: To evaluate the safety of the C2 pedicle and pars screw placement without fluoroscopic or other guidance methods...
November 16, 2017: Spine Journal: Official Journal of the North American Spine Society
https://www.readbyqxmd.com/read/29154894/non-contrast-quantitative-pulmonary-perfusion-using-flow-alternating-inversion-recovery-at-3t-a-preliminary-study
#6
Joshua S Greer, Christopher D Maroules, Orhan K Oz, Suhny Abbara, Ronald M Peshock, Ivan Pedrosa, Ananth J Madhuranthakam
PURPOSE: To demonstrate the initial feasibility of non-contrast quantitative pulmonary perfusion imaging at 3T using flow alternating inversion recovery (FAIR), and to evaluate the intra-session and inter-session reliability of FAIR measurements at 3T. MATERIALS AND METHODS: Nine healthy volunteers were imaged using our own implementation of FAIR pulse sequence on 3T. Quantitative FAIR perfusion, both with and without larger pulmonary vessels, was correlated with global phase contrast (PC) measured blood flow in the right pulmonary artery (RPA)...
November 14, 2017: Magnetic Resonance Imaging
https://www.readbyqxmd.com/read/29154796/treatment-of-cancer-by-low-intensity-laser-radiation-therapy
#7
REVIEW
Sahar E Abo-Neima
Cancer treatment is one of the main challenges that face the scientific centers all over the world. The cancer incidence percentage increases year after year. The most used treatment for cancer is chemotherapy which is an application of systemic cytotoxic drug inside the patient. There are two main problems in chemotherapy that the cytotoxic drug is given systematically and cannot be localized in the tumor region in most cases that lead to killing the cancer cells as well as normal cells; and that cause the chemotherapy side effects like anemia, decrease in all blood cells count and platelets, nausea, vomiting, diarrhea, hair and nails loss and may cause a kind of blood toxicity...
November 14, 2017: Progress in Biophysics and Molecular Biology
https://www.readbyqxmd.com/read/29154759/radiation-exposure-in-pediatric-urology-patients-how-to-adhere-to%C3%A2-alara
#8
EDITORIAL
Michael C Ost
No abstract text is available yet for this article.
November 14, 2017: Journal of Urology
https://www.readbyqxmd.com/read/29154259/evaluation-of-coefficients-to-derive-organ-and-effective-doses-from-cone-beam-ct-cbct-scans-a-monte-carlo-study
#9
Abdullah Abuhaimed, Colin J Martin
Regular imaging is used throughout image guided radiation therapy (IGRT) to improve treatment delivery. In order for treatment procedures to be optimized, the doses delivered by imaging exposures should be taken into account. CT dosimetry methods based on the CT dose index (CTDI), measured with a 100 mm long pencil ionization chamber (CTDI<sub>100</sub>) in standard phantoms, are not designed for the cone beam CT (CBCT) imaging systems used in radiotherapy, therefore a modified version has been proposed for CBCT by the International Electrotechnical Commission (CTDI<sub>IEC</sub>)...
November 20, 2017: Journal of Radiological Protection: Official Journal of the Society for Radiological Protection
https://www.readbyqxmd.com/read/29154199/ultraviolet-b-radiation-down-regulates-ulk1-and-atg7-expression-and-impairs-the-autophagy-response-in-human-keratinocytes
#10
Xu Chen, Li Li, Song Xu, Wenbo Bu, Kun Chen, Min Li, Heng Gu
Autophagy is a self-digestive pathway that helps to maintain cellular homeostasis, and many autophagy-related gene (ATG)s involved the regulation of the autophagy process. Ultraviolet light is a common stressor of skin, but it is unclear how autophagy is regulated after ultraviolet exposure in epidermal keratinocytes. Here, we found that the mRNAs of some key ATG genes such as ULK1, ATG5 and ATG7 exhibited significantly lower levels in the skin tissues of the face and chest with solar ultraviolet exposure, compared with perineal skin...
September 4, 2017: Journal of Photochemistry and Photobiology. B, Biology
https://www.readbyqxmd.com/read/29154135/acute-exposure-to-sunscreen-containing-titanium-induces-an-adaptive-response-and-oxidative-stress-in-mytillus-galloprovincialis
#11
Antoni Sureda, Xavier Capó, Carla Busquets-Cortés, Silvia Tejada
The use of sunscreens to protect against ultraviolet radiation exposure progressively increases as result of a greater awareness of the people and the greater arrival of tourists. The components of these creams can end up in the waters affecting coastal species. Mediterranean mussels (Mytillus galloprovincialis) were subjected to an acute exposure of a sunscreen with TiO2 in their composition during 24h. The low and medium concentrations used in the assays contained a concentration of TiO2 in the range of values found in coastal waters of the Balearic Islands...
November 15, 2017: Ecotoxicology and Environmental Safety
https://www.readbyqxmd.com/read/29153770/rats-exposed-to-2-45ghz-of-non-ionizing-radiation-exhibit-behavioral-changes-with-increased-brain-expression-of-apoptotic-caspase-3
#12
Rini Varghese, Anuradha Majumdar, Girish Kumar, Amit Shukla
In recent years there has been a tremendous increase in use of Wi-Fi devices along with mobile phones, globally. Wi-Fi devices make use of 2.4GHz frequency. The present study evaluated the impact of 2.45GHz radiation exposure for 4h/day for 45days on behavioral and oxidative stress parameters in female Sprague Dawley rats. Behavioral tests of anxiety, learning and memory were started from day 38. Oxidative stress parameters were estimated in brain homogenates after sacrificing the rats on day 45. In morris water maze, elevated plus maze and light dark box test, the 2...
November 14, 2017: Pathophysiology: the Official Journal of the International Society for Pathophysiology
https://www.readbyqxmd.com/read/29153361/noise-reduction-angiographic-imaging-technology-reduces-radiation-dose-during-bronchial-artery-embolization
#13
C Spink, M Avanesov, T Schmidt, M Grass, G Schoen, G Adam, A Koops, H Ittrich, P Bannas
PURPOSE: Comparison of radiation doses in patients undergoing angiographic bronchial artery embolization (BAE) before and after a noise reduction imaging technology upgrade. METHODS: We performed a retrospective study of 70 patients undergoing BAE. Procedures were performed before (n=32) and after (n=38) the technology upgrade containing additional filters and improved image-processing. Cumulative air kerma (AK), cumulative dose area product (DAP), number of exposure frames, total fluoroscopy time and amount of contrast agent were recorded...
December 2017: European Journal of Radiology
https://www.readbyqxmd.com/read/29152107/neoadjuvant-olaparib-targets-hypoxia-to-improve-radioresponse-in-a-homologous-recombination-proficient-breast-cancer-model
#14
Gerben R Borst, Ramya Kumareswaran, Hatice Yücel, Seyda Telli, Trevor Do, Trevor McKee, Gaetano Zafarana, Jos Jonkers, Marcel Verheij, Mark J O'Connor, Sven Rottenberg, Robert G Bristow
Clinical trials are studying the benefits of combining the PARP-1 inhibitor olaparib with chemotherapy and radiotherapy treatment in a variety of cancer increasing the therapeutic ratio for olaparib may come from its ability to modify the tumour microenvironment by targeting homologous recombination-deficient, hypoxic tumour clonogens, and/or increasing tumour-associated vasodilation to improve oxygenation. Herein, we investigated the effect of prolonged neoadjuvant exposure to olaparib on the tumor microenvironment using a genetically-engineered mouse p53-/- syngeneic breast cancer model, which is proficient in homology-directed DNA repair...
October 20, 2017: Oncotarget
https://www.readbyqxmd.com/read/29152092/the-long-non-coding-rna-particle-is-associated-with-wwox-and-the-absence-of-fra16d-breakage-in-osteosarcoma-patients
#15
Valerie Bríd O'Leary, Doris Maugg, Jan Smida, Daniel Baumhoer, Michaela Nathrath, Saak Victor Ovsepian, Michael John Atkinson
Breakage of the fragile site FRA16D disrupts the WWOX (WW Domain Containing Oxidoreductase) tumor suppressor gene in osteosarcoma. However, the frequency of breakage is not sufficient to explain the rate of WWOX loss in pathogenesis. The involvement of non-coding RNA transcripts is proposed due to their accumulation at fragile sites, where they are advocated to influence specific chromosomal regions associated with malignancy. The long ncRNA PARTICLE (promoter of MAT2A antisense radiation-induced circulating long non-coding RNA) is transiently elevated in response to irradiation and influences epigenetic silencing modification within WWOX...
October 20, 2017: Oncotarget
https://www.readbyqxmd.com/read/29151870/elevated-mitochondrial-genome-variation-after-50-generations-of-radiation-exposure-in-a-wild-rodent
#16
Robert J Baker, Benjamin Dickins, Jeffrey K Wickliffe, Faisal A A Khan, Sergey Gaschak, Kateryna D Makova, Caleb D Phillips
Currently, the effects of chronic, continuous low dose environmental irradiation on the mitochondrial genome of resident small mammals are unknown. Using the bank vole (Myodes glareolus) as a model system, we tested the hypothesis that approximately 50 generations of exposure to the Chernobyl environment has significantly altered genetic diversity of the mitochondrial genome. Using deep sequencing, we compared mitochondrial genomes from 131 individuals from reference sites with radioactive contamination comparable to that present in northern Ukraine before the 26 April 1986 meltdown, to populations where substantial fallout was deposited following the nuclear accident...
September 2017: Evolutionary Applications
https://www.readbyqxmd.com/read/29151818/lifetime-cost-effectiveness-analysis-of-intraoperative-radiation-therapy-versus-external-beam-radiation-therapy-for-early-stage-breast-cancer
#17
Rakesh Patel, Olga Ivanov, Jeff Voigt
Background: To date no one has examined the quality of life and direct costs of care in treating early stage breast cancer with adjunct intraoperative radiation therapy (IORT) versus external beam radiation therapy (EBRT) over the life of the patient. As well no one has examined the effects of radiation exposure with both therapies on the longer term sequelae. The purpose of this analysis was to examine the cost-effectiveness of IORT vs. EBRT over the life of the patient. Methods: A Markov decision-analytic model evaluated these treatment strategies in terms of the direct costs in treating patients over their lifetime (including the downstream costs associated with radiation exposure) and the resultant quality of life of these patients...
2017: Cost Effectiveness and Resource Allocation: C/E
https://www.readbyqxmd.com/read/29151568/a-comparison-of-the-mini-open-wiltse-approach-with-pedicle-screw-fixation-and-the-percutaneous-pedicle-screw-fixation-for-neurologically-intact-thoracolumbar-fractures
#18
Yong Fan, JiaNan Zhang, Xin He, YunFei Huang, QiNing Wu, DingJun Hao
BACKGROUND The thoracolumbar AO type A3 fracture is an incomplete burst fracture, which affects one vertebral body endplate. The objective of this study was to determine which of two minimal invasive techniques was more suitable for A3 fractures based on clinical and radiographic results. MATERIAL AND METHODS We studied 112 patients with A3 subtype fractures without neurological deficits. A total of 63 patients received percutaneous pedicle screw fixation (PPSF), and 49 patients were treated using mini-open Wiltse approach with pedicle screw fixation (MWPSF)...
November 20, 2017: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
https://www.readbyqxmd.com/read/29150395/transradial-versus-transfemoral-arterial-access-in-liver-cancer-embolization-randomized-trial-to-assess-patient-satisfaction
#19
Ricardo Yamada, Stephen Bracewell, Beatriz Bassaco, Juan Camacho, M Bret Anderson, Andrew Conrad, Corie Lynn, Paul Burns, Heather Collins, Marcelo Guimaraes
PURPOSE: To determine whether transradial access (TRA) or transfemoral access (TFA) provides better patient satisfaction during intra-arterial therapy (IAT) for liver cancer. MATERIALS AND METHODS: This randomized, prospective, intra- and interpatient controlled trial compared TRA vs TFA accesses in patients with primary or metastatic liver cancer undergoing IAT. After having one of each type of access (1 TRA and 1 TFA), all patients selected their preferred access regardless of whether a third intervention was indicated...
November 15, 2017: Journal of Vascular and Interventional Radiology: JVIR
https://www.readbyqxmd.com/read/29150285/a-review-of-prevalence-studies-of-autism-spectrum-disorder-by-latitude-and-solar-irradiance-impact
#20
Somayya Syed, Kathleen A Moore, Evita March
Autism Spectrum Disorder (ASD) is a lifelong disability with no known cause or cure. Among the suggested etiologies, is Cannell's hypothesis of a deficiency in Vitamin D the main natural source of which is Solar Ultraviolet-B (UVB) radiation. The aim in this paper is to build on this hypothesis and explore the relationship of solar irradiance of which UVB is a component, by latitude with the prevalence rates of ASD. Twenty-five reports published between 2011 and 2016 using comparable diagnostic criteria were reviewed...
November 2017: Medical Hypotheses
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