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https://www.readbyqxmd.com/read/28107697/egcg-a-tea-polyphenol-as-a-potential-mitigator-of-hematopoietic-radiation-injury-in-mice
#1
Mrinalini Tiwari, Bhakti Dixit, Suhel Parvez, Paban K Agrawala
Agents capable of providing protection, mitigation or therapy against radiation injuries have long been of interest of radiation biologists owing to the ever expanding application of radiation in our day to day life despite the well reported ill effects of exposure. The current study investigates radiomitigating potential of EGCG (epigallocatechin gallate), a tea polyphenol with known DNMT inhibitory property, in C57 Bl/6 mice model. Treatment with 0.1833mg/kg body weight EGCG, 1.5h post-irradiation to lethally whole body irradiated mice rendered 45% survival for 30days and also helped restoring the body weight of the animals...
January 17, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/28106829/advances-in-monitoring-cell-based-therapies-with-magnetic-resonance-imaging-future-perspectives
#2
REVIEW
Ethel J Ngen, Dmitri Artemov
Cell-based therapies are currently being developed for applications in both regenerative medicine and in oncology. Preclinical, translational, and clinical research on cell-based therapies will benefit tremendously from novel imaging approaches that enable the effective monitoring of the delivery, survival, migration, biodistribution, and integration of transplanted cells. Magnetic resonance imaging (MRI) offers several advantages over other imaging modalities for elucidating the fate of transplanted cells both preclinically and clinically...
January 19, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28106686/response-to-comments-by-drs-hamaoka-and-beyea-on-the-birth-of-the-illegitimate-linear-no-threshold-model-an-invalid-paradigm-for-estimating-risk-following-low-dose-radiation-exposure
#3
Jeffry A Siegel, Bill Sacks, Charles W Pennington, James S Welsh
No abstract text is available yet for this article.
February 2017: American Journal of Clinical Oncology
https://www.readbyqxmd.com/read/28105159/small-bowel-metastasis-from-pancreatic-cancer-in-a-long-term-survival-patient-with-synchronous-advanced-malignant-pleural-mesothelioma-a-case-report-and-literature-review
#4
Morena Fasano, Carminia Maria Della Corte, Giovanni Vicidomini, Valerio Scotti, Pier Francesco Rambaldi, Alfonso Fiorelli, Marina Accardo, Ferdinando De Vita, Mario Santini, Fortunato Ciardiello, Floriana Morgillo
Diffuse malignant pleural mesothelioma (MPM) is an aggressive tumor that originates from the surface of the pleura. Approximately 70% of cases are associated with chronic asbestos exposure. MPM is regarded as an incurable disease, with a median survival of ~2 years following intensive multimodality treatment. Pancreatic cancer is a malignancy also associated with a poor prognosis, with only 2% of patients surviving for 5 years. The majority of patients with pancreatic cancer are diagnosed with an advanced stage of disease and experience a poor response to therapy...
December 2016: Oncology Letters
https://www.readbyqxmd.com/read/28104643/reduced-patient-radiation-exposure-during-neurodiagnostic-and-interventional-x-ray-angiography-with-a-new-imaging-platform
#5
K van der Marel, S Vedantham, I M J van der Bom, M Howk, T Narain, K Ty, A Karellas, M J Gounis, A S Puri, A K Wakhloo
BACKGROUND AND PURPOSE: Advancements in medical device and imaging technology as well as accruing clinical evidence have accelerated the growth of the endovascular treatment of cerebrovascular diseases. However, the augmented role of these procedures raises concerns about the radiation dose to patients and operators. We evaluated patient doses from an x-ray imaging platform with radiation dose-reduction technology, which combined image noise reduction, motion correction, and contrast-dependent temporal averaging with optimized x-ray exposure settings...
January 19, 2017: AJNR. American Journal of Neuroradiology
https://www.readbyqxmd.com/read/28104641/measured-head-ct-cta-skin-dose-and-intensive-care-unit-patient-cumulative-exposure
#6
R D Nawfel, G S Young
BACKGROUND AND PURPOSE: Estimates of cumulative CT/CTA radiation dose based on volumetric CT dose index have raised concern that neurological intensive care unit patient exposures may reach thresholds for deterministic skin injury. Because the accuracy of volumetric CT dose index for this purpose in unknown, we set out to directly measure head CT and CTA peak skin dose, assess the relationship of volumetric CT dose index to measured peak skin dose, and determine whether multiple CT/CTA exposures in typical patients in the neurological intensive care unit produce cumulative doses approaching or exceeding single-dose deterministic thresholds for skin injury...
January 19, 2017: AJNR. American Journal of Neuroradiology
https://www.readbyqxmd.com/read/28104526/total-navigation-in-spine-surgery-a-concise-guide-to-eliminate-fluoroscopy-using-a-portable-intraoperative-ct-3d-navigation-system
#7
Rodrigo Navarro-Ramirez, Gernot Lang, Xiaofeng Lian, Connor Berlin, Insa Janssen, Ajit Jada, Marjan Alimi, Roger Härtl
BACKGROUND: Portable intraoperative computed tomography (iCT) with integrated 3D navigation offers new opportunities for more precise navigation in spinal surgery, eliminates radiation exposure for the surgical team and accelerates surgical workflows. We present the concept of "total navigation" using iCT NAV in spinal surgery. Therefore, we propose a step-by-step guideline demonstrating how total navigation can eliminate fluoroscopy with time efficient workflows integrating iCT NAV into daily practice...
January 16, 2017: World Neurosurgery
https://www.readbyqxmd.com/read/28103708/intravoxel-incoherent-motion-ivim-analysis-of-vertebral-bone-marrow-changes-after-radiation-exposure-from-diagnostic-imaging-and-interventional-procedures
#8
Min A Yoon, Suk-Joo Hong, Chang Hee Lee, Chang Ho Kang, Kyung-Sik Ahn, Baek Hyun Kim
Background High cumulative radiation dose in cancer patients warrants systemic examination of possible changes in bone marrow. Purpose To assess retrospectively changes in vertebral bone marrow diffusion and perfusion using intravoxel incoherent motion diffusion-weighted imaging (IVIM-DWI) in hepatocellular carcinoma (HCC) patients after exposure to radiation from diagnostic imaging and interventional procedures. Material and Methods A total of 21 IVIM-DWI sets in 20 HCC patients, consisting of baseline and follow-up liver magnetic resonance imaging (MRI) with an interval less than 100 days, were reviewed after varying levels of radiation exposure from transarterial chemoembolization (TACE), multiphase liver CT, and abdominal radiography...
January 1, 2017: Acta Radiologica
https://www.readbyqxmd.com/read/28102953/air-kerma-strength-determination-of-an-hdr-192-ir-source-including-a-geometric-sensitivity-study-of-the-seven-distance-method
#9
Blake R Smith, John A Micka, Manik Aima, Larry A DeWerd, Wesley S Culberson
PURPOSE: To perform an in-air air-kerma strength (SK) calibration of the Bebig model Ir2.A85-2 192Ir high-dose rate (HDR) brachytherapy source manufactured by Mallinckrodt Medical (Westerduinweg, Germany) with the NIST-traceable seven-distance technique established by the University of Wisconsin. A comparison was made between the reference air-kerma rate (RAKR) reported on a certificate from the Physikalisch-Technische Bundesanstalt (Berlin, Germany) (PTB) primary laboratory and the SK determined at the University of Wisconsin Madison Radiation Research Center (UWMRRC)...
January 2017: Medical Physics
https://www.readbyqxmd.com/read/28102667/two-different-structures-of-the-oxygen-evolving-complex-in-the-same-polypeptide-frameworks-of-photosystem-ii
#10
Ayako Tanaka, Yoshimasa Fukushima, Nobuo Kamiya
The oxygen-evolving complex (OEC) forms the heart of photosystem II (PSII) in photosynthesis. The crystal structure of PSII from Thermosynechococcus vulcanus has been reported at a resolution of 1.9 Å and at an averaged X-ray dose of 0.43 MGy. The OEC structure is suggested to be partially reduced to Mn(II) by EXAFS and DFT compu-tational studies. Recently, the "radiation-damage-free" struc-tures have been published at 1.95 Å resolution using XFEL, but reports continued to appear that the OEC is reduced to the S0-state of the Kok cycle...
January 19, 2017: Journal of the American Chemical Society
https://www.readbyqxmd.com/read/28102497/regulated-partitioning-of-fixed-carbon-14-c-sodium-na-potassium-k-and-glycine-betaine-determined-salinity-stress-tolerance-of-gamma-irradiated-pigeonpea-cajanus-cajan-l-millsp
#11
Pankaj Kumar, Vasundhara Sharma, Chobhe Kapil Atmaram, Bhupinder Singh
Soil salinity is a major constraint that limits legume productivity. Pigeonpea is a salt sensitive crop. Seed gamma irradiation at a very low dose (2.5 Gy) is known to enhance seedling establishment, plant growth and yield of cereals and other crops. The present study conducted using two genetically diverse varieties of pigeonpea viz., Pusa-991 and Pusa-992 aimed at establishing the role of pre-sowing seed gamma irradiation at 0, 0.0025, 0.005, 0.01, 0.02, 0.05 and 0.1 kGy on plant growth, seed yield and seed quality under salt stress at 0, 80 and 100 mM NaCl (soil solution EC equivalent 1...
January 19, 2017: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/28102439/reconstruction-of-radionuclide-intakes-for-the-residents-of-east-urals-radioactive-trace-1957-2011
#12
Evgenia I Tolstykh, Lyudmila M Peremyslova, Marina O Degteva, Bruce A Napier
The East Urals Radioactive Trace (EURT) was formed after a chemical explosion in the radioactive waste-storage facility of the Mayak Production Association in 1957 (Southern Urals, Russia) and resulted in an activity dispersion of 7.4 × 10(16) Bq into the atmosphere. Internal exposure due to ingestion of radionuclides with local foodstuffs was the main factor of public exposure at the EURT. The EURT cohort, combining residents of most contaminated settlements, was formed for epidemiological study at the Urals Research Center for Radiation Medicine, Russia (URCRM)...
January 19, 2017: Radiation and Environmental Biophysics
https://www.readbyqxmd.com/read/28102417/does-sunlight-protect-us-from-cancer
#13
Jacqueline E Marshall, Scott N Byrne
The Ultraviolet (UV) radiation contained in sunlight is a powerful mutagen and immune suppressant which partly explains why exposure to solar UV is the biggest risk factor for the development of cutaneous tumours. Evidence is building that sunlight may be protective against some internal malignancies. Because patients with these tumours are often vitamin D deficient, this has led some to propose that vitamin D supplementation will be beneficial in the treatment of these cancers. However, the results from already completed trials have been disappointing which has given weight to the argument that there must be something else about sunlight that explains its cancer-protecting properties...
January 19, 2017: Photochemical & Photobiological Sciences
https://www.readbyqxmd.com/read/28101417/investigation-of-terahertz-radiation-influence-on-rat-glial-cells
#14
Mariia Borovkova, Maria Serebriakova, Viacheslav Fedorov, Egor Sedykh, Vladimir Vaks, Alexander Lichutin, Alina Salnikova, Mikhail Khodzitsky
We studied an influence of continuous terahertz (THz) radiation (0.12 - 0.18 THz, average power density of 3.2 mW/cm(2)) on a rat glial cell line. A dose-dependent cytotoxic effect of THz radiation is demonstrated. After 1 minute of THz radiation exposure a relative number of apoptotic cells increased in 1.5 times, after 3 minutes it doubled. This result confirms the concept of biological hazard of intense THz radiation. Diagnostic applications of THz radiation can be restricted by the radiation power density and exposure time...
January 1, 2017: Biomedical Optics Express
https://www.readbyqxmd.com/read/28101017/efficacy-of-a-film-forming-medical-device-containing-piroxicam-and-sun-filters-in-the-treatment-of-multiple-actinic-keratosis-lesions-in-a-subject-with-a-history-of-kaposi-sarcoma
#15
Elisabetta Scotti, Salvatore Deledda, Massimo Milani
Actinic keratosis (AK) is considered a premalignant form of skin cancer due to chronic sun exposure. In addition, human papilloma virus (HPV) has been advocated a role in the pathogenesis of this clinical condition. HPV proteins (mainly E6 and E7) seem to act synergistically with ultraviolet (UV) radiation in reducing the defensive mechanisms of keratinocyte apoptosis after UV damage. Data regarding the involvement of other viruses, i.e. human herpes viruses (HHV), in the pathogenesis of AK are so far controversial...
September 2016: Case Reports in Dermatology
https://www.readbyqxmd.com/read/28100670/two-new-single-exposure-multi-detector-neutron-spectrometers-for-radiation-protection-applications-in-workplace-monitoring
#16
J M Gómez-Ros, R Bedogni, D Bortot, C Domingo, A Esposito, M V Introini, M Lorenzoli, G Mazzitelli, M Moraleda, A Pola, D Sacco
This communication describes two new instruments, based on multiple active thermal neutron detectors arranged within a single moderator, that permit to unfold the neutron spectrum (from thermal to hundreds of MeV) and to determine the corresponding integral quantities with only one exposure. This makes them especially advantageous for neutron field characterisation and workplace monitoring in neutron-producing facilities. One of the devices has spherical geometry and nearly isotropic response, the other one has cylindrical symmetry and it is only sensitive to neutrons incident along the cylinder axis...
January 17, 2017: Radiation Protection Dosimetry
https://www.readbyqxmd.com/read/28100039/low-dose-radiation-causes-skin-cancer-in-mice-and-has-a-differential-effect-on-distinct-epidermal-stem-cells
#17
Tatiana Revenco, Gaelle Lapouge, Virginie Moers, Sylvain Brohée, Panagiota A Sotiropoulou
The carcinogenic effect of ionizing radiation has been evaluated based on limited populations accidently exposed to high dose radiation. In contrast, insufficient data are available on the effect of low dose radiation, such as radiation deriving from medical investigations and interventions, as well as occupational exposure that concern a large fraction of western populations. Using mouse skin epidermis as a model, we showed that low dose radiation results in DNA damage in sebaceous gland and bulge epidermal stem cells (SCs)...
January 18, 2017: Stem Cells
https://www.readbyqxmd.com/read/28099922/pafr-selectively-mediates-radioresistance-and-irradiation-induced-autophagy-suppression-in-prostate-cancer-cells
#18
Bing Yao, Bingqian Liu, Lei Shi, Xiang Li, Chuanchuan Ren, Mingbo Cai, Wen Wang, Jianhua Li, Yongde Sun, Yudong Wu, Jianguo Wen
Platelet-activating factor receptor (PAFR) promotes tumorigenesis, angiogenesis and metastasis. Here, we defined the PAFR as a yielding new inhibiting target to selectively enhance the sensitivity of prostate cancer (PCa) cells to radiation. The selective responding to PAFR inhibiter may be caused by the differential expression pattern of PAFR in PCa cells. In this study, we also determined PAFR as a molecular basis by which the radiation induces autophagy suppression independent of activating mTOR pathway...
January 14, 2017: Oncotarget
https://www.readbyqxmd.com/read/28099497/assessing-the-mental-health-impact-of-the-2011-great-japan-earthquake-tsunami-and-radiation-disaster-on-elementary-and-middle-school-children-in-the-fukushima-prefecture-of-japan
#19
Mark Lieber
BACKGROUND: On March 11, 2011, a magnitude 9.0 earthquake occurred off of Japan's Pacific coast, which was followed by huge tsunamis that destroyed many coastal cities in the area. Due to the earthquake and subsequent tsunami, malfunctions occurred at the Fukushima Daiichi (Fukushima I) nuclear power plant, resulting in the release of radioactive material in the region. While recent studies have investigated the effects of these events on the mental health of adults in the region, no studies have yet been performed investigating similar effects among children...
2017: PloS One
https://www.readbyqxmd.com/read/28099337/phototoxic-maculopathy-induced-by-quartz-infrared-heat-lamp-a-clinical-case-report
#20
Xinhua Zheng, Ping Xie, Zizhong Hu, Weiwei Zhang, Kang Liang, Xiuying Wang, Qinghuai Liu
RATIONALE: A large proportion of the output of quartz infrared heat lamps is emitted as infrared radiation (IR). Retinal damage induced by IR-A and visible light on arc welders has been reported. However, case reports of retinal damage caused by quartz infrared heat lamps are rare. To the best of our knowledge, this is the first reported case of phototoxic maculopathy induced by quartz infrared heat lamps. PATIENT CONCERNS: We report a female with a 1-month history of progressive blurred vision and dysmorphopsia in her right eye after improper staring at the tubes of a quartz infrared heater...
January 2017: Medicine (Baltimore)
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