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https://www.readbyqxmd.com/read/29678677/photodynamic-inactivation-of-candida-ssp-on-denture-stomatitis-a-clinical-trial-involving-palatal-mucosa-and-prosthesis-disinfection
#1
André M de Senna, Martha M F Vieira, Rosa Maria Machado-de-Sena, Aparecido O Bertolin, Silvia C Núñez, Martha S Ribeiro
Denture stomatitis (DS) is the most common oral fungal infection in denture wearers. Photodynamic inactivation (PDI) has been showing to be an effective technique in vivo against fungi, including fungal infections in the oral cavity. The disinfection of both oral mucosa and denture may represent a real advantage in terms of fungus control. This clinical study was designed to explore methylene blue (MB)-mediated PDI on oral mucosa and prosthesis of patients with DS. Subjects with DS were divided into two groups...
April 17, 2018: Photodiagnosis and Photodynamic Therapy
https://www.readbyqxmd.com/read/29676728/detection-of-candida-species-in-pregnant-chinese-women-with-a-molecular-beacon-method
#2
Yanhong Zhai, Jing Liu, Li Zhou, Tongzhen Ji, Lingxin Meng, Yang Gao, Ran Liu, Xiao Wang, Lin Li, Binghuai Lu, Zheng Cao
PURPOSE: Candida pathogens are commonly found in women and can cause vulvovaginal candidiasis (VVC), whose infection rate is further increased during pregnancy. We aimed to study the Candida prevalence and strain distribution in pregnant Chinese women with a molecular beacon assay. METHODOLOGY: From March 2016 to February 2017, a total of 993 pregnant women attending routine antenatal visits at the Beijing Obstetrics and Gynecology Hospital were enrolled. For Candida detection and identification, a unique molecular beacon assay was presented and compared with a traditional phenotypic method...
April 20, 2018: Journal of Medical Microbiology
https://www.readbyqxmd.com/read/29675786/the-microbiology-of-infected-pancreatic-necrosis-in-the-era-of-minimally-invasive-therapy
#3
Nadav Sahar, Richard A Kozarek, Zaheer S Kanji, Shingo Chihara, S Ian Gan, Shayan Irani, Michael Larsen, Andrew S Ross, Michael Gluck
We aimed to determine the microbiology of infected walled-off pancreatic necrosis (WON) in an era of minimally invasive treatment, since current knowledge is based on surgical specimens performed over two decades ago. We retrospectively analyzed a prospectively maintained database of patients who were treated for symptomatic WON using combined endoscopic and percutaneous drainage between 2008 and 2017. Aspirates from WON at initial treatment were evaluated. One hundred eighty-two patients were included with a mean age of 56 of whom 67% were male...
April 19, 2018: European Journal of Clinical Microbiology & Infectious Diseases
https://www.readbyqxmd.com/read/29674635/design-synthesis-biological-activity-and-structure-activity-relationship-studies-of-chalcone-derivatives-as-potential-anti-candida-agents
#4
Jéssica T Andrade, Felipe R S Santos, William G Lima, Carla D F Sousa, Lohanna S F M Oliveira, Rosy I M A Ribeiro, Ana J P S Gomes, Marcelo G F Araújo, José A F P Villar, Jaqueline M S Ferreira
Vulvovaginal candidiasis (VVC) affects millions of women around the world every year. Candida albicans is the most frequently isolated pathogen in women and its rapid ability to develop resistance to first and second line therapies has boosted the search for new and effective antifungal agents. In this study, we show the in vitro anti-Candida activity of fifteen synthetic chalcone analogs and their antifungal potential in an in vivo model of VVC. Chalcone 12 showed potent antifungal effects, being able to inhibit the growth of Candida spp...
April 19, 2018: Journal of Antibiotics
https://www.readbyqxmd.com/read/29670781/-candida-krusei-empyema-thoracis-a-community-acquired-infection-requiring-a-high-index-of-suspicion
#5
Hazim Bukamur, Waseem Ahmed, Yazan Numan, Ibrahim Shahoub, Fuad Zeid
Empyema thoracis is a serious condition characterized by the accumulation of purulent fluid in the pleural cavity, typically following a pneumonia, subdiaphragmatic abscess, or esophageal rupture. Fungal empyema thoracis is a rare form of this condition with especially high mortality, in which the most frequently isolated fungus is Candida spp. This article presents a 74-year-old female with Candida krusei pneumonia and a complicated hospital course, initially presenting with nausea, vomiting, and dysphagia...
2018: Case Reports in Infectious Diseases
https://www.readbyqxmd.com/read/29669499/qsar-study-of-some-1-3-oxazolylphosphonium-derivatives-as-new-potent-anti-candida-agents-and-their-toxicity-evaluation
#6
Maria M Trush, Vasyl Kovalishyn, Alla D Ocheretniuk, Oleksandr L Kobzar, Maryna V Kachaeva, Volodymyr S Brovarets, Larisa O Metelytsia
This paper describes QSAR studies by using the Online Chemical Modeling Environment, synthesis, in vitro antifungal activity of 1,3-oxazolylphosphonium derivatives and their acetylcholinesterase inhibitory potential. Three classification QSAR models were created using Random Forests (WEKA-RF), k-Nearest Neighbors and Associative Neural Networks methods and different combinations of descriptors. The predictive ability of the models was tested through cross-validation, giving a balanced accuracy BA=80-91%. All compounds demonstrated good antifungal properties and slight inhibition of acetylcholinesterase activity...
April 18, 2018: Current Drug Discovery Technologies
https://www.readbyqxmd.com/read/29665644/biodistribution-of-free-and-encapsulated-99m-tc-fluconazole-in-an-infection-model-induced-by-candida-albicans
#7
Danielle Nogueira de Assis, Raquel Silva Araújo, Leonardo Lima Fuscaldi, Simone Odília Antunes Fernandes, Vanessa Carla Furtado Mosqueira, Valbert Nascimento Cardoso
BACKGROUND: Candida spp is an etiologic agent of fungal infections in hospitals and resistance to treatment with antifungals has been extensively reported. Thus, it is very important to develop formulations that increase effectiveness with low toxicity. In this sense, nanocarriers have been investigated, once they modify drug biodistribution profile. Thus, this study aimed to evaluate the biodistribution of free and encapsulated 99m Tc-fluconazole into nanocapsules (NCs) in an experimental immunosuppressed murine model of Candida albicans infection...
March 2018: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/29665443/activity-of-a-nitric-oxide-generating-wound-treatment-system-against-wound-pathogen-biofilms
#8
Richard D Waite, Joanne E Stewart, Abish S Stephen, Robert P Allaker
Wound bioburden plays an important role in impaired healing and the development of infection-related complications. The objective of this study was to determine the efficacy of an innovative two-layer nitric oxide generating system (NOx) to prevent and treat biofilms formed by bacterial and fungal pathogens commonly associated with wound infection, and activity against Pseudomonas aeruginosa virulence factors. Single and mixed species biofilms were grown for 24h on nitrocellulose filters placed on agar. Filters were covered with either NOx or placebo, before and after biofilm formation...
April 14, 2018: International Journal of Antimicrobial Agents
https://www.readbyqxmd.com/read/29661606/potential-effect-of-2-isopropyl-5-methylphenol-thymol-alone-and-in-combination-with-fluconazole-against-clinical-isolates-of-candida-albicans-c-glabrata-and-c-krusei
#9
A Sharifzadeh, A R Khosravi, H Shokri, H Shirzadi
Limitations of antifungals used in the treatment of candidiasis, as the development of resistant strains, are known by the scientific community. In this context, the aim of this study was to investigate the activity of 2-isopropyl-5-methylphenol (thymol) in combination with fluconazole (FLZ) against clinical Candida strains. The antifungal activity of thymol along with FLZ was evaluated by the Clinical Laboratory Standards Institute (CLSI) M27-A2 broth microdilution method. In addition, synergism was observed for clinical strains of Candida spp...
April 14, 2018: Journal de Mycologie Médicale
https://www.readbyqxmd.com/read/29656714/epidemiology-of-sepsis-in-intensive-care-units-in-turkey-a-multicenter-point-prevalence-study
#10
Nur Baykara, Halis Akalın, Mustafa Kemal Arslantaş, Volkan Hancı, Çiğdem Çağlayan, Ferda Kahveci, Kubilay Demirağ, Canan Baydemir, Necmettin Ünal
BACKGROUND: The prevalence and mortality of sepsis are largely unknown in Turkey, a country with high antibiotic resistance. A national, multicenter, point-prevalence study was conducted to determine the prevalence, causative microorganisms, and outcome of sepsis in intensive care units (ICUs) in Turkey. METHODS: A total of 132 ICUs from 94 hospitals participated. All patients (aged > 18 years) present at the participating ICUs or admitted for any duration within a 24-h period (08:00 on January 27, 2016 to 08:00 on January 28, 2016) were included...
April 16, 2018: Critical Care: the Official Journal of the Critical Care Forum
https://www.readbyqxmd.com/read/29656657/phytochemical-profile-and-biological-activities-of-deverra-tortuosa-desf-dc-a-desert-aromatic-shrub-widespread-in-northern-region-of-saudi-arabia
#11
Arbi Guetat, Abdennacer Boulila, Mohamed Boussaid
The present study describes the chemical composition of the essential oil of different plant parts of Devrra tortuosa; in vivo and in vitro biological activities of plant extract and essential oils. Apiol was found to be the major component of the oil (between 65.73% and 74.41%). The best antioxidant activities were observed for the oil of flowers (IC50 = 175 μg/ml). The samples of stems and roots exhibit lower antioxidant activity (IC50 = 201 μg/ml and 182 μg/ml, respectively). The values of IC50 showed that the extracts of methanol exhibit the highest antioxidants activities (IC50 = 64...
April 16, 2018: Natural Product Research
https://www.readbyqxmd.com/read/29656214/study-of-virulence-factor-of-candida-species-in-oral-lesions-and-its-association-with-potentially-malignant-and-malignant-lesions
#12
Graciela Del Valle Castillo, Silvia López de Blanc, Claudia Elena Sotomayor, Ana Isabel Azcurra
OBJECTIVE: The aim of this study was to explore the association between malignant and premalignant lesions and the virulence factor profile of Candida spp. recovered from different oral lesions. DESIGN: Candida spp. isolated from malignant lesions (squamous cell carcinoma, OC, n = 25), atypical lichen planus (AL, n = 11), chronic candidiasis (CC, n = 25), and asymptomatic carriers (WI, n = 15, control strains.) Isolates were identified in chromogenic medium, colony morphology and biochemical tests...
February 19, 2018: Archives of Oral Biology
https://www.readbyqxmd.com/read/29655372/population-pharmacokinetics-pharmacodynamics-of-micafungin-against-candida-species-in-obese-critically-ill-and-morbidly-obese-critically-ill-patients
#13
Emilio Maseda, Santiago Grau, Sonia Luque, Maria-Pilar Castillo-Mafla, Alejandro Suárez-de-la-Rica, Ana Montero-Feijoo, Patricia Salgado, Maria-Jose Gimenez, Carlos A García-Bernedo, Fernando Gilsanz, Jason A Roberts
BACKGROUND: Dosing in obese critically ill patients is challenging due to pathophysiological changes derived from obesity and/or critical illness, and it remains fully unexplored. This study estimated the micafungin probability of reaching adequate 24-h area under the curve (AUC0-24h )/minimum inhibitory concentration (MIC) values against Candida spp. for an obese/nonobese, critically ill/noncritically ill, large population. METHODS: Blood samples for pharmacokinetic analyses were collected from 10 critically ill nonobese patients, 10 noncritically ill obese patients, and 11 critically ill morbidly obese patients under empirical/directed micafungin treatment...
April 15, 2018: Critical Care: the Official Journal of the Critical Care Forum
https://www.readbyqxmd.com/read/29651438/effect-of-different-carbon-sources-on-biosurfactants-production-by-three-strains-of-lactobacillus-spp
#14
Tene Hippolyte Mouafo, Augustin Mbawala, Robert Ndjouenkeu
The potential of three indigenous bacterial strains ( Lactobacillus delbrueckii N2, Lactobacillus cellobiosus TM1, and Lactobacillus plantarum G88) for the production of biosurfactants using sugar cane molasses or glycerol as substrates was investigated through emulsifying, surface tension, and antimicrobial activities. The different biosurfactants produced with molasses as substrate exhibited high surface tension reduction from 72 mN/m to values ranged from 47.50 ± 1.78 to 41.90 ± 0.79 mN/m and high emulsification index ranging from 49...
2018: BioMed Research International
https://www.readbyqxmd.com/read/29649828/risk-analysis-for-invasive-fungal-infection-after-living-donor-liver-transplantation-which-patient-needs-potent-prophylaxis
#15
Masashi Utsumi, Yuzo Umeda, Takahito Yagi, Takeshi Nagasaka, Susumu Shinoura, Ryuich Yoshida, Daisuke Nobuoka, Takashi Kuise, Tomokazu Fuji, Kosei Takagi, Akinobu Takaki, Toshiyoshi Fujiwara
BACKGROUND: Invasive fungal infection (IFI) is associated with high mortality after living donor liver transplant (LDLT). The aim of this study was to identify the risk factors for post-LDLT IFI for early diagnosis and improvement of antifungal treatment outcome. METHODS: Risk analysis data were available for all 153 patients who underwent LDLT between January 2005 and April 2012. RESULTS: During the follow-up period (1,553 ± 73 days, range 20-2,946 days), 15 patients (9...
April 12, 2018: Digestive Surgery
https://www.readbyqxmd.com/read/29643195/diagnostic-performance-of-a-molecular-test-versus-clinician-assessment-of-vaginitis
#16
Jane R Schwebke, Charlotte A Gaydos, Paul Nyirjesy, Sonia Paradis, Salma Kodsi, Charles K Cooper
Background: Vaginitis is a common complaint, diagnosed either empirically or using Amsel's criteria and wet mount microscopy. Objective: To determine characteristics of an investigational test (a molecular-based test for vaginitis), as compared to reference, for detection of bacterial vaginosis, Candida spp., and Trichomonas vaginalis Study Design: Vaginal specimens from a cross-sectional study were obtained from 1,740 women (≥18 years old), with vaginitis symptoms, during routine clinic visits (across 10 sites in the USA)...
April 11, 2018: Journal of Clinical Microbiology
https://www.readbyqxmd.com/read/29628769/antifungal-susceptibility-testing-of-vulvovaginal-candida-species-among-women-attending-antenatal-clinic-in-tertiary-care-hospitals-of-peshawar
#17
Maria Khan, Jawad Ahmed, Amina Gul, Aamer Ikram, Farida Khurram Lalani
Background: Vulvovaginal candidiasis (VVC) is considered as a pervasive gynecological problem among women worldwide. Owing to this fact, in the current study, we aimed at assessing the prevalence rate of Candida spp. causing VVC in symptomatic pregnant women and their antifungal susceptibility pattern. Methods: This study was carried out in the tertiary care hospitals of Peshawar during the period of July 1, 2016 to December 31, 2016. The study group included 450 pregnant women in the age group of 17-44 years with symptoms of excessive vaginal discharge, pain and pruritis...
2018: Infection and Drug Resistance
https://www.readbyqxmd.com/read/29617502/the-frequency-of-infective-endocarditis-in-candida-bloodstream-infections-a-retrospective-study-in-a-child-hospital
#18
Ahu Kara, İlker Devrim, Timur Meşe, Nuri Bayram, Murat Yılmazer, Gamze Gülfidan
INTRODUCTION: Fungal endocarditis is reported less frequently than bacterial endocarditis, with an incidence of 0-12% of the total pediatric infective endocarditis. OBJECTIVE: In this study, the incidence of infective endocarditis in Candida bloodstream infections in a tertiary hospital during the periods of 2007 and 2016 was reviewed. METHODS: Patients with positive blood or catheter cultures in terms of Candida spp. during the study period of January 2007 and January 2016 were analyzed in terms of Candida infective endocarditis...
January 2018: Brazilian Journal of Cardiovascular Surgery
https://www.readbyqxmd.com/read/29617284/t2-magnetic-resonance-assay-overview-of-available-data-and-clinical-implications
#19
REVIEW
Ioannis M Zacharioudakis, Fainareti N Zervou, Eleftherios Mylonakis
Invasive candidiasis is a common healthcare-associated infection with a high mortality rate that can exceed 60% in cases of septic shock. Blood culture performance is far from ideal, due to the long time to positivity and suppression by antifungal agents. The T2 Magnetic Resonance (T2MR) assay is an FDA-approved qualitative molecular diagnostic method that can detect and speciate the 5 most common Candida spp.; namely, Candida albicans , Candida glabrata , Candida parapsilosis , Candida tropicalis , and Candida krusei , in approximately 5 h...
April 4, 2018: Journal of Fungi (Basel, Switzerland)
https://www.readbyqxmd.com/read/29615504/conservation-and-divergence-in-the-candida-species-biofilm-matrix-mannan-glucan-complex-structure-function-and-genetic-control
#20
Eddie Dominguez, Robert Zarnowski, Hiram Sanchez, Antonio S Covelli, William M Westler, Parastoo Azadi, Jeniel Nett, Aaron P Mitchell, David R Andes
Candida biofilms resist the effects of available antifungal therapies. Prior studies with Candida albicans biofilms show that an extracellular matrix mannan-glucan complex (MGCx) contributes to antifungal sequestration, leading to drug resistance. Here we implement biochemical, pharmacological, and genetic approaches to explore a similar mechanism of resistance for the three most common clinically encountered non- albicans Candida species (NAC). Our findings reveal that each Candida species biofilm synthesizes a mannan-glucan complex and that the antifungal-protective function of this complex is conserved...
April 3, 2018: MBio
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