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Candida spp

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https://www.readbyqxmd.com/read/28238268/aryl-alkyl-lysines-membrane-active-fungicides-that-act-against-biofilms-of-candida-albicans
#1
Chandradhish Ghosh, Vikas Yadav, Waleed Younis, Haroon Mohammad, Youssef A Hegazy, Mohamed N Seleem, Kaustuv Sanyal, Jayanta Haldar
Mortality due to pathogenic fungi has been exacerbated by the rapid development of resistance to frontline antifungal drugs. Fungicidal compounds with novel mechanisms of action are urgently needed. Aryl-alkyl-lysines, which are membrane-active small molecules, were earlier shown to be broad-spectrum antibacterial agents with potency in vitro and in vivo. Herein, we report the antifungal properties of aryl-alkyl-lysines. After identifying the most active compound (NCK-10), we tested its activity against a panel of clinically relevant pathogenic fungi and examined NCK-10's effect against immature and mature biofilms of Candida albicans...
February 27, 2017: ACS Infectious Diseases
https://www.readbyqxmd.com/read/28229205/-spectrum-of-pathogens-in-postoperative-complications-of-visceral-surgery-the-problem-of-multidrug-resistance
#2
A Kramer, J Pochhammer, P Walger, U Seifert, M Ruhnke, J C Harnoss
In general surgery the etiology of surgical site infections has not significantly changed over the last 30 years. Gram-positive bacteria, e.g. coagulase negative staphylococci (CNS), Staphylococcus aureus and Enterococcus spp. as well as Gram-negative bacteria, e.g. Escherichia coli, Enterobacter spp., Klebsiella spp. and Pseudomonas aeruginosa, are the most common findings. Although in general surgery 10% of the S. aureus causing postoperative wound infections were methicillin resistant (MRSA), no cases of multidrug-resistant Gram-negative (MRGN) bacteria were reported...
February 22, 2017: Der Chirurg; Zeitschrift Für Alle Gebiete der Operativen Medizen
https://www.readbyqxmd.com/read/28225185/preventive-effects-of-topical-washing-with-miconazole-nitrate-containing-soap-to-diaper-candidiasis-in-hospitalized-elderly-patients-a-prospective-double-blind-placebo-controlled-study
#3
Hidenori Takahashi, Noritaka Oyama, Izumi Tanaka, Michiko Hasegawa, Kaori Hirano, Chieko Shimada, Minoru Hasegawa
The objective of the present randomized, double-blind trial was to evaluate the efficacy and safety of daily washing with miconazole nitrate-containing soap for candidiasis at diaper-covered sites in elderly subjects under long-term inpatient care. To confirm the onset and disappearance of candidiasis, we microscopically evaluated the existence of the pseudohyphae and/or blastoconidia of Candida spp. We enrolled 75 elderly patients who wore diapers all day in the hospital or nursing home. Patients were randomly assigned to receive treatment with either miconazole soap or miconazole-free placebo soap, and 28 patients in the miconazole group and 27 patients in the placebo group were followed for 4 weeks...
February 22, 2017: Journal of Dermatology
https://www.readbyqxmd.com/read/28222388/microbial-profile-of-dental-plaque-associated-to-white-spot-lesions-in-orthodontic-patients-immediately-after-the-bracket-removal
#4
Moniek W Beerens, Jacob M Ten Cate, Monique H van der Veen
OBJECTIVE: Denaturing Gradient Gel Electrophoresis (DGGE) is suggested to predict caries risk in young children. Such a tool would be valuable in orthodontic patients undergoing treatment with fixed appliances. In this cross-sectional study the applicability of DGGE and conventional microbiology for caries risk assessment in orthodontic patients were assessed. DESIGN: Dental plaque was obtained from orthodontic patients immediately prior to bracket removal. Presence of white spot lesions (WSL) was assessed immediately post debracketing...
February 9, 2017: Archives of Oral Biology
https://www.readbyqxmd.com/read/28213809/the-correlation-between-biofilm-production-and-catheter-related-blood-stream-infections-sustained-by-candida-a-case-control-study
#5
Grazia Brunetti, Valeria Visconti, Maria Cristina Ghezzi, Alessandra Giordano, Giammarco Raponi
Biofilm forming capacity of yeasts colonizing the intravenous devices is considered a key factor involved in the pathogenesis of Candida catheter-related bloodstream infections (CCRBSI). The biofilm production of strains of Candida spp. isolated both from the CVC and from the blood of patients with CCRBSI was compared to that of strains isolated from patients not having CCRBSI. Results, expressed in terms of Biofilm Index (BI), revealed that biofilm-producing strains were isolated in the CCRBSI group with a frequency significantly higher than in the non-CCRBSI group (χ(2) = 4...
February 18, 2017: Advances in Experimental Medicine and Biology
https://www.readbyqxmd.com/read/28204571/in-vitro-combination-therapy-with-isavuconazole-against-candida-spp
#6
Aspasia Katragkou, Matthew McCarthy, Joseph Meletiadis, Kaiser Hussain, Patriss W Moradi, Gittel E Strauss, Kyaw L Myint, Myo H Zaw, Laura L Kovanda, Ruta Petraitiene, Emmanuel Roilides, Thomas J Walsh, Vidmantas Petraitis
No abstract text is available yet for this article.
February 16, 2017: Medical Mycology: Official Publication of the International Society for Human and Animal Mycology
https://www.readbyqxmd.com/read/28204565/effect-of-peritoneal-dialysis-fluids-on-activity-of-echinocandins-against-candida-spp-biofilm
#7
Selma Tobudic, Nicole Harrison, Christina Forstner, Manuel Kussman, Heinz Burgmann
No abstract text is available yet for this article.
February 16, 2017: Medical Mycology: Official Publication of the International Society for Human and Animal Mycology
https://www.readbyqxmd.com/read/28198976/role-of-candida-species-from-hiv-infected-children-in-enamel-caries-lesions-an-in-vitro-study
#8
Senda Charone, Maristela Barbosa Portela, Karol de Oliveira Martins, Rosangela Maria Soares, Gloria Fernanda Castro
Objectives: This study analyzed the capacity of Candida spp. from dental biofilm of HIV infected (HIV+) children to demineralize primary molar enamel in vitro by Transversal Microhardness (TMH), Polarized Light Microscopy (PLM) and the quantity of calcium ions (Ca2+) released from the enamel. Material and Methods: Candida spp. samples were isolated from the supragingival biofilm of HIV+ children. A hundred and forty (140) enamel blocks were randomly assigned to six groups: biofilm formed by C...
January 2017: Journal of Applied Oral Science: Revista FOB
https://www.readbyqxmd.com/read/28195093/molecular-identification-of-candida-species-isolated-from-cases-of-neonatal-candidemia-using-polymerase-chain-reaction-restriction-fragment-length-polymorphism-in-a-tertiary-care-hospital
#9
Akeela Fatima, Gulnaz Bashir, Tehmeena Wani, Abiroo Jan, Amrish Kohli, Mosin S Khan
CONTEXT: Candida spp. is an emerging cause of bloodstream infections worldwide. Delay in speciation of Candida isolates by conventional methods and resistance to antifungal drugs in various Candida species are responsible for the increase in morbidity and mortality due to candidemia. Hence, the rapid identification of Candida isolates is very important for the proper management of patients with candidemia. AIMS: The aim was to re-evaluate the identification of various Candida spp...
January 2017: Indian Journal of Pathology & Microbiology
https://www.readbyqxmd.com/read/28177048/use-of-fluorescent-oligonucleotide-probes-for-differentiation-between-paracoccidioides-brasiliensis-and-paracoccidioides-lutzii-in-yeast-and-mycelial-phase
#10
Thales Domingos Arantes, Raquel Cordeiro Theodoro, Marcus de Melo Teixeira, Eduardo Bagagli
BACKGROUND: Fluorescence in situ hybridisation (FISH) associated with Tyramide Signal Amplification (TSA) using oligonucleotides labeled with non-radioactive fluorophores is a promising technique for detection and differentiation of fungal species in environmental or clinical samples, being suitable for microorganisms which are difficult or even impossible to culture. OBJECTIVE: In this study, we aimed to standardise an in situ hybridisation technique for the differentiation between the pathogenic species Paracoccidioides brasiliensis and Paracoccidioides lutzii, by using species-specific DNA probes targeting the internal transcribed spacer-1 (ITS-1) of the rRNA gene...
February 2017: Memórias do Instituto Oswaldo Cruz
https://www.readbyqxmd.com/read/28175309/the-novel-oral-glucan-synthase-inhibitor-scy-078-shows-in-vitro-activity-against-sessile-and-planktonic-candida-spp
#11
Laura Judith Marcos-Zambrano, Marta Gómez-Perosanz, Pilar Escribano, Emilio Bouza, Jesús Guinea
No abstract text is available yet for this article.
February 8, 2017: Journal of Antimicrobial Chemotherapy
https://www.readbyqxmd.com/read/28167892/selection-of-small-synthetic-antimicrobial-peptides-inhibiting-xanthomonas-citri-subsp-citri-causing-citrus-canker
#12
Jeahyuk Choi, Euiho Park, Se-Weon Lee, Jae-Wook Hyun, Kwang-Hyun Baek
Citrus canker disease decreases the fruit quality and yield significantly, furthermore, emerging of streptomycin-resistant pathogens threatens the citrus industry seriously because of a lack of proper control agents. Small synthetic antimicrobial peptides (AMPs) could be a promising alternative. Fourteen hexapeptides were selected by using positional scanning of synthetic peptide combinatorial libraries. Each hexapeptide showed different antimicrobial spectrum against Bacillus, Pseudomonas, Xanthomonas, and Candida species...
February 2017: Plant Pathology Journal
https://www.readbyqxmd.com/read/28161884/usefulness-of-procalcitonin-in-differentiating-candida-and-bacterial-blood-stream-infections-in-critically-ill-septic-patients-outside-the-intensive-care-unit
#13
Filippo Pieralli, Lorenzo Corbo, Arianna Torrigiani, Dario Mannini, Elisa Antonielli, Antonio Mancini, Francesco Corradi, Fabio Arena, Alberto Moggi Pignone, Alessandro Morettini, Carlo Nozzoli, Gian Maria Rossolini
We aimed to explore the role of procalcitonin (PCT) for the diagnosis of Candida spp. bloodstream infections in a population of critically ill septic patients admitted to internal medicine units. This is a retrospective case-control study considering all cases of candidemia identified in three internal medicine units, from January 1st 2012 to May 31st 2016. For each case of candidemia, two patients with bacteremic sepsis were included in the study as control cases. The end point of the study was to evaluate the diagnostic performance of PCT for the diagnosis of Candida spp...
February 4, 2017: Internal and Emergency Medicine
https://www.readbyqxmd.com/read/28159945/simultaneous-two-site-blood-culture-in-diagnosis-of-neonatal-sepsis
#14
Priya Tomar, Amit Garg, Rashee Gupta, Abhishek Singh, Navratan Kumar Gupta, Amit Upadhyay
OBJECTIVE: To evaluate efficacy of two blood cultures taken simultaneously from two different sites as compared to standard practice of single blood culture in diagnosis of neonatal sepsis. Study. DESIGN: Prospective cohort study. SETTING: A tertiary care center of North India from August 2014-July 2015. PARTICIPANTS: 475 neonates admitted to our intensive care unit with suspected sepsis. INTERVENTION: Two blood cultures drawn from two different peripheral veins in patients with suspected neonatal sepsis...
February 2, 2017: Indian Pediatrics
https://www.readbyqxmd.com/read/28158577/in-vitro-activity-of-the-novel-echinocandin-cd101-at-ph-7-and-4-against-candida-spp-isolates-from-patients-with-vulvovaginal-candidiasis
#15
Dina A Boikov, Jeffrey B Locke, Kenneth D James, Ken Bartizal, Jack D Sobel
No abstract text is available yet for this article.
February 3, 2017: Journal of Antimicrobial Chemotherapy
https://www.readbyqxmd.com/read/28154488/antifungal-activity-of-lactic-acid-bacteria-strains-isolated-from-natural-honey-against-pathogenic-candida-species
#16
Bulgasem Y Bulgasem, Mohd Nizam Lani, Zaiton Hassan, Wan Mohtar Wan Yusoff, Sumaya G Fnaish
The role of lactic acid bacteria (LAB) in honey as antifungal activity has received little attention and their mechanism of inhibitory of fungi is not fully understood. In this study, LAB were isolated from honey samples from Malaysia, Libya, Saudi Arabia, and Yemen. Twenty-five isolates were confirmed LAB by catalase test and Gram staining, and were screened for antifungal activity. Four LAB showed inhibitory activity against Candida spp. using the dual agar overlay method. And they were identified as Lactobacillus plantarum HS isolated from Al-Seder honey, Lactobacillus curvatus HH isolated from Al-Hanon honey, Pediococcus acidilactici HC isolated from Tualang honey and Pediococcus pentosaceus HM isolated from Al-Maray honey by the 16S rDNA sequence...
December 2016: Mycobiology
https://www.readbyqxmd.com/read/28154258/the-risk-of-microbial-contamination-in-multiple-dose-preservative-free-ophthalmic-preparations
#17
Atsuyuki Saisyo, Rima Shimono, Shigeharu Oie, Kazuhiro Kimura, Hiroyuki Furukawa
Multiple-dose ophthalmic preparations that do not contain preservatives carry high risks of microbial contamination. However, there are various types of hospital preparations, with different physicochemical properties. In the present study, we evaluated the association between physicochemical properties and microbial contamination in ophthalmic preparations. The investigated hospital preparations included ophthalmic preparations of physiological saline, 0.2% fluconazole, 0.5% vancomycin hydrochloride, and 2% cyclosporine...
2017: Biological & Pharmaceutical Bulletin
https://www.readbyqxmd.com/read/28149227/epidemiology-of-nosocomial-fungal-infections-in-the-national-center-for-burns-in-casablanca-morocco
#18
A Rafik, M Diouri, N Bahechar, A Chlihi
Fungal infection is a leading cause of death in burns patients and incurs significant costs for burn units. Our aim was to determine epidemiology of these infections, and analyze risk factors in the burns intensive care unit of the National Center for Burns and Plastic Surgery at Ibn-Rochd University Hospital, Casablanca. It is a retrospective review of all patients admitted from 2011-2014 who developed cultures positive for fungal organisms. Criteria for nosocomial fungal infections were those of the Center for Disease Control in Atlanta (1988, revised 1992, 2004)...
June 30, 2016: Annals of Burns and Fire Disasters
https://www.readbyqxmd.com/read/28149146/antifungal-susceptibility-and-risk-factors-in-patients-with-candidemia
#19
Cigdem Mermutluoglu, Ozcan Deveci, Saim Dayan, Emel Aslan, Fatma Bozkurt, Recep Tekin
OBJECTIVE: This study aimed to investigate the antifungal susceptibility, typology, and risk factors of candidemia among adult and pediatric inpatients at a university hospital. MATERIALS AND METHODS: A case-control study was designed, and data collected between December 2013 and December 2014 were retrospectively evaluated. The case group consisted of patients with candidemia. The control group was selected from the inpatients that did not develop candidemia but were admitted in the same clinic and during the same period as the candidemia group...
October 2016: Eurasian Journal of Medicine
https://www.readbyqxmd.com/read/28144840/population-pharmacokinetic-model-and-pharmacokinetic-target-attainment-of-micafungin-in-intensive-care-unit-patients
#20
Lisa C Martial, Rob Ter Heine, Jeroen A Schouten, Nicole G Hunfeld, Henk J van Leeuwen, Paul E Verweij, Dylan W de Lange, Peter Pickkers, Roger J Brüggemann
OBJECTIVE: To study the pharmacokinetics of micafungin in intensive care patients and assess pharmacokinetic (PK) target attainment for various dosing strategies. METHODS: Micafungin PK data from 20 intensive care unit patients were available. A population-PK model was developed. Various dosing regimens were simulated: licensed regimens (I) 100 mg daily; (II) 100 mg daily with 200 mg from day 5; and adapted regimens 200 mg on day 1 followed by (III) 100 mg daily; (IV) 150 mg daily; and (V) 200 mg daily...
January 31, 2017: Clinical Pharmacokinetics
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