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https://www.readbyqxmd.com/read/29046215/prospective-surveillance-of-device-associated-health-care-associated-infection-in-an-intensive-care-unit-of-a-tertiary-care-hospital-in-new-delhi-india
#1
Shilpee Kumar, Poornima Sen, Rajni Gaind, Pardeep Kumar Verma, Poonam Gupta, Prem Rose Suri, Sunita Nagpal, Anil Kumar Rai
BACKGROUND: Surveillance of health care-associated infections (HAIs) plays a key role in the hospital infection control program and reduction of HAIs. In India, most of the surveillance of HAIs is reported from private sector hospitals that do not depict the situation of government sector hospitals. Other studies do not confirm with the Centers for Disease Control and Prevention's (CDC) National Healthcare Safety Network (NHSN) surveillance criterion, or deal with ventilator-associated pneumonia (VAP) instead of ventilator-associated event (VAE)...
October 15, 2017: American Journal of Infection Control
https://www.readbyqxmd.com/read/29038271/evaluation-of-antifungal-efficacy-of-three-new-cyclic-lipopeptides-of-the-class-bacillomycin-from-bacillus-subtilis-rlid-12-1
#2
Ramya R, Manjari Shrivastava, Namitha N N, Ram Lal Thakur, Arunaloke Chakrabarti, Utpal Roy
New lipopeptide homologues (AF3, AF4 and AF5) with antifungal activities against Candida and Cryptococcus spp. were purified from the cell free supernatant of Bacillus subtilis RLID 12.1. The lipopeptides AF3, AF4 and AF5 were identified with the same peptide sequence Asn-Pro-Tyr-Asn-Gln-Thr-Ser with variations in the fatty acid branching type and chain length (anteiso-C17, iso-C17 and iso-C18 respectively). Comparing the three homologues for minimum inhibitory concentrations (MIC) against 81 Candida (64 no...
October 16, 2017: Antimicrobial Agents and Chemotherapy
https://www.readbyqxmd.com/read/29026191/mechanisms-involved-in-the-triggering-of-neutrophil-extracellular-traps-nets-by-candida-glabrata-during-planktonic-and-biofilm-growth
#3
Chad J Johnson, John F Kernien, Amanda R Hoyer, Jeniel E Nett
Candida spp. adhere to medical devices, such as catheters, forming drug-tolerant biofilms that resist killing by the immune system. Little is known about how C. glabrata, an emerging pathogen, resists attack by phagocytes. Here we show that upon encounter with planktonic (non-biofilm) C. glabrata, human neutrophils initially phagocytose the yeast and subsequently release neutrophil extracellular traps (NETs), complexes of DNA, histones, and proteins capable of inhibiting fungal growth and dissemination. When exposed to C...
October 12, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29016613/quantification-of-carious-pathogens-in-the-interdental-microbiota-of-young-caries-free-adults
#4
Denis Bourgeois, Alexandra David, Camille Inquimbert, Paul Tramini, Nicolas Molinari, Florence Carrouel
BACKGROUND: The majority of caries lesions in adults occur on the proximal tooth surfaces of the posterior teeth. A comprehensive study of the composition of the oral microbiota is fundamental for a better understanding of the etiology of interdental caries. METHODS: Twenty-five caries-free subjects (20-35 years old) were enrolled in the study. The interdental biofilm of four interdental sites were collected. The real-time polymerase chain reaction (PCR) methodology were used to quantify (i) the following bacteria: Streptococcus spp...
2017: PloS One
https://www.readbyqxmd.com/read/28988525/the-role-of-biofilm-forming-on-mortality-in-patients-with-candidemia-a-study-derived-from-real-world-data
#5
Carlo Tascini, Emanuela Sozio, Laura Corte, Francesco Sbrana, Claudio Scarparo, Andrea Ripoli, Giacomo Bertolino, Maria Merelli, Enrico Tagliaferri, Antonio Corcione, Matteo Bassetti, Gianluigi Cardinali, Francesco Menichetti
BACKGROUND: Evaluation of the role on patient mortality exerted by biofilm forming (BF) Candida strains, by using predictive clinical data. METHODS: Eighty-nine strains isolated from Candida bloodstream infection, occurring in two Italian University Hospitals, were employed in this study. A random forest (RF) model was built with a procedure of iterative selection of the risk factors potentially able to predict the probability of death. The similarity between patient conditions and Bayesian clustering was calculated in order to evaluate the role of predictors in the stratification of the death risk...
October 9, 2017: Infectious Diseases
https://www.readbyqxmd.com/read/28983822/in-vitro-activity-of-micafungin-against-biofilms-of-candida-albicans-candida-glabrata-and-candida-parapsilosis-at-different-stages-of-maturation
#6
Małgorzata Prażyńska, Tomasz Bogiel, Eugenia Gospodarek-Komkowska
Candida spp. is able to form a biofilm, which is considered resistant to the majority of antifungals used in medicine. The aim of this study was to evaluate the in vitro activity of micafungin against Candida spp. biofilms at different stages of their maturation (2, 6, and 24 h). We assessed the inhibitory effect of micafungin against 78 clinical isolates of Candida spp., growing as planktonic or sessile cells, by widely recommended broth microdilution method. The in vitro effect on sessile cells viability was evaluated by colorimetric reduction assay...
October 5, 2017: Folia Microbiologica
https://www.readbyqxmd.com/read/28982951/in-vitro-synergy-of-natamycin-and-voriconazole-against-clinical-isolates-of-fusarium-candida-aspergillus-and-curvularia-spp
#7
Swatishree Sradhanjali, Bandana Yein, Savitri Sharma, Sujata Das
AIM: To determine the minimum inhibitory concentrations (MICs) of voriconazole and natamycin, alone and in combination, against the clinical isolates of Fungus and to evaluate the synergy between the drugs in an experimental in vitro study. METHODS: In an experimental in vitro study, clinical isolates of Fusarium, Aspergillus, Candida and Curvularia spp were maintained on Sabouraud Dextrose Agar and used for the study. The MICs of natamycin and voriconazole, used alone and in combination, were evaluated by checkerboard microdilution technique based on the standard protocol proposed by the Clinical Laboratory Standards Institute...
October 5, 2017: British Journal of Ophthalmology
https://www.readbyqxmd.com/read/28977047/antifungal-activity-of-linalool-in-cases-of-candida-spp-isolated-from-individuals-with-oral-candidiasis
#8
I J Dias, E R I S Trajano, R D Castro, G L S Ferreira, H C M Medeiros, D Q C Gomes
This study analyzed the antifungal activity of phytoconstituents from linalool on Candida spp. strains, in vitro, isolated from patients with clinical diagnoses of oral candidiasis associated with the use of a dental prosthesis. Biological samples were collected from 12 patients using complete dentures or removable partial dentures and who presented mucous with diffuse erythematous or stippled features, indicating a clinical diagnosis of candidiasis. To identify fungal colonies of the genus Candida, samples were plated onto CHROMagar Candida®...
September 28, 2017: Brazilian Journal of Biology, Revista Brasleira de Biologia
https://www.readbyqxmd.com/read/28975802/a-new-small-molecule-kre2-inhibitor-against-invasive-candida-parapsilosis-infection
#9
Tânia P Salci, Melyssa Negri, Ana Karina R Abadio, P Bonfim-Mendonça, Isis Capoci, Silvana M Caparroz-Assef, Lucélia Donati, Maria Sueli S Felipe, Erika S Kioshima, Terezinha Ie Svidzinski
AIM: To investigate the antifungal activity of MOL3, a small molecule that was selected by virtual screening, against Candida spp. MATERIALS & METHODS: The antifungal activity of MOL3 was evaluated using standard strains and clinical isolates. Activity was evaluated in both in vitro tests and animal models. RESULTS: The minimum fungicidal concentration of MOL3 against Candida spp. ranged from 16 to 128 mg/l. MOL3 at the sub-minimum fungicidal concentration inhibited hyphal elongation...
October 4, 2017: Future Microbiology
https://www.readbyqxmd.com/read/28975031/procalcitonin-for-the-diagnosis-of-invasive-candidiasis-what-is-the-evidence
#10
Santi Maurizio Raineri, Andrea Cortegiani, Filippo Vitale, Pasquale Iozzo, Antonino Giarratano
Procalcitonin is a widely used marker for the evaluation of infection and sepsis and to guide antibiotic therapy. During the last decade, several studies evaluated its role and diagnostic performance as a surrogate marker for the identification of Candida spp. in suspected invasive candidiasis. A low serum level and a favorable negative predictive value are the main findings for procalcitonin in this setting. The aim of this report is to provide an updated brief summary of the evidence supporting the use of PCT for the management of invasive candidiasis...
2017: Journal of Intensive Care
https://www.readbyqxmd.com/read/28972465/prevalence-and-genetic-diversity-of-trichomonas-vaginalis-in-the-general-population-of-granada-and-co-infections-with-gardnerella-vaginalis-and-candida-species
#11
José Antonio Carrillo-Ávila, María Luisa Serrano-García, Jorge Fernández-Parra, Antonio Sorlózano-Puerto, José María Navarro-Marí, C Rune Stensvold, Jose Gutiérrez-Fernández
PURPOSE: Purulent or exudative genitourinary infections are a frequent cause of consultation in primary and specialized healthcare. The objectives of this study were: to determine the prevalence of Trichomonas vaginalis and co-infections with Candida spp. and Gardnerella vaginalis in vaginal secretion; and to use multilocus sequence typing (MLST) to analyse the genetic diversity of T. vaginalis strains. METHODOLOGY: The samples were submitted for analysis (n=5230) to a third-level hospital in Granada (Southern Spain) between 2011 and 2014; eight T...
October 2017: Journal of Medical Microbiology
https://www.readbyqxmd.com/read/28970174/antimicrobial-and-antibiofilm-activities-of-nanoemulsions-containing-eucalyptus-globulus-oil-against-pseudomonas-aeruginosa-and-candida-spp
#12
Priscilla Maciel Quatrin, Camila Marina Verdi, Márcia Ebling de Souza, Samantha Nunes de Godoi, Bruna Klein, Andre Gundel, Roger Wagner, Rodrigo de Almeida Vaucher, Aline Ferreira Ourique, Roberto Christ Vianna Santos
Candida species are the main responsible microorganisms for causing fungal infections worldwide, and Candida albicans is most frequently associated with infectious processes. Pseudomonas aeruginosa is a gram-negative bacterium commonly found in immunocompromised patients. The infection persistence caused by these microorganisms is often related to antimicrobial resistance and biofilm formation. In this context, the objective of the present study was to prepare and characterize nanoemulsions containing Eucalyptus globulus oil and to verify its antimicrobial and antibiofilm activities against P...
September 29, 2017: Microbial Pathogenesis
https://www.readbyqxmd.com/read/28969122/comparative-study-on-the-vaginal-flora-and-incidence-of-asymptomatic-vaginosis-among-healthy-women-and-in-women-with-infertility-problems-of-reproductive-age
#13
Geethavani Babu, Balamuru Ganvelu Singaravelu, R Srikumar, Sreenivasalu V Reddy, Afraa Kokan
INTRODUCTION: The normal vaginal flora is highly complex, dominated by lactobacilli of doderlein that plays a vital role in maintaining the women's health and inhibits other pathogenic microorganisms. Fluctuation in local environment or exposure to any exogenous and endogenous sources changes the vaginal flora over a period of time. Disruption of the vaginal ecosystem changes the microflora of the healthy vagina, altering the pH and predisposing to lower reproductive tract infections...
August 2017: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/28969120/isolation-and-speciation-of-candida-in-type-ii-diabetic-patients-using-chrom-agar-a-microbial-study
#14
Usha Sharma, Krupa Patel, Vandana Shah, Surabhi Sinha, Vishnu Pratap Singh Rathore
INTRODUCTION: Newer Candida species are now becoming increasingly predominant commensal in the oral cavity. AIM: Aim of the study was to identify and compare different Candida species in the oral cavity of Type II diabetic individuals. MATERIALS AND METHODS: The present microbial study was carried out for the duration of three months. Sixty participants were included in the study and divided into two groups of 30 individual each. Group I consisted of patients with Type II diabetes while Group II consisted of healthy individuals without diabetes or any other systemic disease...
August 2017: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/28964999/yeast-community-in-traditional-portuguese-serpa-cheese-by-culture-dependent-and-independent-dna-approaches
#15
Maria Teresa P Gonçalves Dos Santos, María José Benito, María de Guía Córdoba, Nuno Alvarenga, Santiago Ruiz-Moyano Seco de Herrera
This study investigated the yeast community present in the traditional Portuguese cheese, Serpa, by culture-dependent and -independent methods. Sixteen batches of Serpa cheeses from various regional industries registered with the Protected Designation of Origin (PDO) versus non-PDO registered, during spring and winter, were used. Irrespective of the producer, the yeast counts were around 5log CFU/g in winter and, overall, were lower in spring. The yeast species identified at the end of ripening (30days), using PCR-RFLP analysis and sequencing of the 26S rRNA, mainly corresponded to Debaryomyces hansenii and Kluyveromyces marxianus, with Candida spp...
December 4, 2017: International Journal of Food Microbiology
https://www.readbyqxmd.com/read/28963991/synthesis-biological-evaluation-and-quantitative-structure-active-relationships-of-1-3-thiazolidin-4-one-derivatives-a-promising-chemical-scaffold-endowed-with-high-antifungal-potency-and-low-cytotoxicity
#16
Simone Carradori, Bruna Bizzarri, Melissa D'Ascenzio, Celeste De Monte, Rossella Grande, Daniela Rivanera, Alessanda Zicari, Emanuela Mari, Manuela Sabatino, Alexandros Patsilinakos, Rino Ragno, Daniela Secci
With reference to recent studies reporting on the various biological properties of the thiazolidinone scaffold, we synthesized more than a hundred compounds characterized by a 1,3-thiazolidin-4-one nucleus derivatised at the C2 with a hydrazine bridge linked to (cyclo)aliphatic or hetero(aryl) moieties, and their N-benzylated derivatives. These molecules were assayed as potential anti-Candida agents and they were shown to possess comparable, and in some cases higher biological activity than well-established topical and systemic antimycotic drugs (i...
September 19, 2017: European Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/28962848/deciphering-the-role-of-sodium-lignosulfonate-against-candida-spp-as-persuasive-anticandidal-agent
#17
Anubhuti Jha, Awanish Kumar
In spite of therapeutic development against life threatening fungal pathogens like Candida albicans, the repertoire of effective antifungal drugs is lagging. The emergence and persistence of azole/echinocandin resistance and other cases of multi-drug resistance have led to the failure of the antifungal treatment regime. This troublesome scenario has steered a need for the development of novel leads. Computer aided in-silico drug design using virtual screening, molecular docking, drug likeness, absorption, distribution, metabolism, excretion, and toxicity analysis for the identification of lead compounds for further in-vitro analysis is a cost effective and time-saving strategy...
September 26, 2017: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/28953940/microbial-abundance-on-the-eggs-of-a-passerine-bird-and-related-fitness-consequences-between-urban-and-rural-habitats
#18
Sang-Im Lee, Hyunna Lee, Piotr G Jablonski, Jae Chun Choe, Magne Husby
Urban environments present novel and challenging habitats to wildlife. In addition to well-known difference in abiotic factors between rural and urban environments, the biotic environment, including microbial fauna, may also differ significantly. In this study, we aimed to compare the change in microbial abundance on eggshells during incubation between urban and rural populations of a passerine bird, the Eurasian Magpie (Pica pica), and examine the consequences of any differences in microbial abundances in terms of hatching success and nestling survival...
2017: PloS One
https://www.readbyqxmd.com/read/28948565/experience-with-saccharomyces-boulardii-probiotic-in-oncohaematological-patients
#19
Beata Sulik-Tyszka, Emilian Snarski, Magda Niedźwiedzka, Małgorzata Augustyniak, Thorvald Nilsen Myhre, Anna Kacprzyk, Ewa Swoboda-Kopeć, Marta Roszkowska, Jadwiga Dwilewicz-Trojaczek, Wiesław Wiktor Jędrzejczak, Marta Wróblewska
Very few reports have been published to date on the bloodstream infections caused by Saccharomyces spp. in oncohaematological patients, and there are no guidelines on the use of this probiotic microorganism in this population. We describe the use of probiotic preparation containing Saccharomyces boulardii in a large group of oncohaematological patients. We retrospectively analysed the data from 32,000 patient hospitalisations at the haematological centre during 2011-2013 (including 196 haematopoietic stem cell transplant recipients) in a tertiary care university-affiliated hospital...
September 25, 2017: Probiotics and Antimicrobial Proteins
https://www.readbyqxmd.com/read/28945064/-candidemia-and-invasive-candidiasis-approach-in-critically-ill-patients-role-of-the-echinocandins
#20
B Almirante, J Garnacho-Montero, E Maseda, F J Candel, S Grau, J Guinea, I Moreno, P Muñoz, S Ruiz-Santana
OBJECTIVE: Invasive infections caused by Candida spp. in critically ill patients may significantly worsen their prognosis, so it is of great importance to establish an early detection and a suitable therapeutic strategy. The objective of this study was to define the differential role of echinocandins in treating certain critical patient profiles. METHODS: A scientific committee of 9 experts in infectious diseases, critical care, microbiology, and hospital pharmacy reviewed the existing evidence on the treatment of candidemia and invasive candidiasis in critically ill patients...
September 25, 2017: Revista Española de Quimioterapia: Publicación Oficial de la Sociedad Española de Quimioterapia
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