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https://www.readbyqxmd.com/read/29220872/new-hydrazide-hydrazones-of-isonicotinic-acid-synthesis-lipophilicity-and-in-vitro-antimicrobial-screening
#1
Łukasz Popiołek, Anna Biernasiuk, Anna Berecka, Anna Gumieniczek, Anna Malm, Monika Wujec
This paper describes the synthesis, lipophilicity and in vitro antimicrobial assays of 15 new hydrazide-hydrazones of isonicotinic acid. New derivatives were obtained on the basis of the condensation reaction of isonicotinic acid hydrazide with different aromatic aldehydes. The chemical structure of synthesized compounds was confirmed by spectral methods. Experimental lipophilicity of new isonicotinic acid derivatives was determined using reversed-phase thin-layer chromatography. All synthesized compounds were subjected to in vitro antimicrobial assays against reference strains of Gram-positive bacteria, Gram-negative bacteria and fungi belonging to Candida spp...
December 8, 2017: Chemical Biology & Drug Design
https://www.readbyqxmd.com/read/29216940/-study-on-risk-factor-of-central-venous-catheter-infection-in-icu-1-160-patients-report
#2
Ming Zhang, Yongqing Xu, Zhiming Jiang, Junying Qian, Zhonghui Zhang, Nannan Sun, Jian Xie, Tao Li
OBJECTIVE: To analyze the etiology and risk factors of central venous catheter (CVCs) infections, and to explore the prophylaxis and treatment for catheter-related infections. METHODS: A retrospective study was conducted. The patients with CVCs admitted to intensive care unit (ICU) of Qianfoshan Hospital Affiliated to Shandong University from January 2000 to December 2016 were enrolled. The gender, age, catheter data and microorganism culture results of all patients were collected...
December 2017: Zhonghua Wei Zhong Bing Ji Jiu Yi Xue
https://www.readbyqxmd.com/read/29214894/phenolic-content-and-in-vitro-antifungal-activity-of-unripe-grape-extracts-from-agro-industrial-wastes
#3
Giovanna Simonetti, Felicia Diodata D'Auria, Nadia Mulinacci, Rosa Anna Milella, Donato Antonacci, Marzia Innocenti, Gabriella Pasqua
The antifungal activity of unripe grape extracts from agro-industrial wastes has been evaluated against several strains of Candida spp. and dermatophytes. All the extracts tested showed antifungal activity. The geometric mean MIC ranged from 53.58 to 214.31 μg/mL for Candida spp. and from 43.54 to 133.02 μg/mL for dermatophytes. The chemical analyses have been carried out using Liquid Chromatograph equipped with a DAD and MS detectors. Flavan-3-ols were the main metabolites within all samples ranged from 3...
December 7, 2017: Natural Product Research
https://www.readbyqxmd.com/read/29207704/opportunistic-microorganisms-in-oral-cavity-according-to-treatment-status-in-head-and-neck-cancer-patients
#4
Priyanka Soni, Rajendra Singh Parihar, Laxman Kumar Soni
Introduction: Cancer patients receiving chemotherapy and/or radiation therapy are prone to many predisposing factors like immunosuppression, imbalance in the oral flora, hypo-salivation and local tissue damage. Therefore, considered to be at higher risk for oral bacterial and fungal infection than the general population. Aim: To study oropharyngeal flora in head and neck cancer patients under treatment and to correlate their incidence according with Chemotherapy cycles and Radiochemotherapy...
September 2017: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/29200950/isolation-and-determination-of-four-potential-antimicrobial-components-from-pseudomonas-aeruginosa-extracts
#5
Ling-Qing Xu, Jian-Wen Zeng, Chong-He Jiang, Huan Wang, Yu-Zhen Li, Wei-Hong Wen, Jie-Hua Li, Feng Wang, Wei-Jen Ting, Zi-Yong Sun, Chih-Yang Huang
Background:Pseudomonas aeruginosa can cause disease and also can be isolated from the skin of healthy people. Additionally, it exhibits certain antimicrobial effects against other microorganisms.Methods: We collected 60 strains of P. aeruginosa and screened their antimicrobial effects against Staphylococcus aureus (ATCC 25923) using the filter paper-disk method, the cross-streaking method and the co-culture method and then evaluated the antimicrobial activity of the chloroform-isolated S. aureus extracts against methicillin-resistant S...
2017: International Journal of Medical Sciences
https://www.readbyqxmd.com/read/29198763/antimicrobial-photodynamic-therapy-mediated-by-photodithazine%C3%A2-in-the-treatment-of-denture-stomatitis-a-case-report
#6
Fernanda Alves, Gabriela Caroline Alonso, Juliana Cabrini Carmello, Ewerton Garcia de Oliveira Mima, Vanderlei Salvador Bagnato, Ana Cláudia Pavarina
Antimicrobial Photodynamic Therapy (aPDT) mediated by Photodithazine® (PDZ) has shown efficacy in the inactivation of Candida spp. in in vitro and in vivo studies. This preliminary study reports five clinical cases of patients with denture stomatitis (DS) treated with PDZ-mediated aPDT. Five individuals diagnosed with DS were selected and submitted to aPDT 3 times a week for 15days (6 sessions). In each session, 200mg/L of PDZ gel was applied on the upper prostheses and on the palate of the patients for 20minutes, then, illuminated by a light emitting diode at 660nm (50J/cm2)...
November 30, 2017: Photodiagnosis and Photodynamic Therapy
https://www.readbyqxmd.com/read/29194382/liposomal-and-deoxycholate-amphotericin-b-formulations-effectiveness-against-biofilm-infections-of-candida-spp
#7
Célia F Rodrigues, Mariana Henriques
BACKGROUND: candidiasis is the primary fungal infection encountered in patients undergoing prolonged hospitalization, and the fourth leading cause of nosocomial bloodstream infections. One of the most important Candida spp. virulence factors is the ability to form biofilms, which are extremely refractory to antimicrobial therapy and very difficult to treat with the traditional antifungal therapies. It is known that the prophylaxis or treatment of a systemic candidiasis are recurrently taken without considering the possibility of a Candida spp...
December 1, 2017: Pathogens
https://www.readbyqxmd.com/read/29190763/in-vitro-activity-of-spirulina-platensis-water-extract-against-different-candida-species-isolated-from-vulvo-vaginal-candidiasis-cases
#8
Antonella Marangoni, Claudio Foschi, Matteo Micucci, Rogers Alberto Nahui Palomino, Tullia Gallina Toschi, Beatrice Vitali, Luca Camarda, Mara Mandrioli, Marta De Giorgio, Rita Aldini, Ivan Corazza, Alberto Chiarini, Roberto Cevenini, Roberta Budriesi
The high incidence of vulvo-vaginal candidiasis, combined with the growing problems about azole resistance and toxicity of antifungal drugs, highlights the need for the development of new effective strategies for the treatment of this condition. In this context, natural compounds represent promising alternatives. The cyanobacterium Spirulina platensis, a blue-green alga, exhibits antimicrobial activities against several microorganisms. Nevertheless, only few data about the antifungal properties of Spirulina platensis are available and its potential toxic effects have not been largely investigated...
2017: PloS One
https://www.readbyqxmd.com/read/29183771/comparative-study-for-147-candida-spp-identification-and-echinocandins-susceptibility-in-isolates-obtained-from-blood-cultures-in-15-hospitals-medellin-colombia
#9
Indira Berrio, Natalia Maldonado, Catalina De Bedout, Karen Arango, Luz Elena Cano, Yorlady Valencia, Cristina Jiménez-Ortigosa, David S Perlin, Beatriz L Gómez, Carlos Robledo, Jaime Robledo
INTRODUCTION: Invasive candidiasis has high impact on morbidity and mortality in hospitalized patients. Accurate and timely methods for identification of Candida species and determination of equinocandins susceptibility become a priority for laboratories of clinical microbiology. METHODS: A study was performed to compare MALDI-TOF MS identification to sequencing of D1/D2 region of rRNA gene complex 28 subunit, in 147 isolates obtained from patients with candidemia...
November 25, 2017: Journal of Global Antimicrobial Resistance
https://www.readbyqxmd.com/read/29178772/antimicrobial-action-and-long-term-effect-of-overnight-denture-cleansers
#10
Amanda Peracini, Ingrid Machado Andrade, Viviane Cássia Oliveira, Ana Paula Macedo, Claudia Helena Silva-Lovato, Valéria Oliveira Pagnano, Evandro Watanabe, Helena de Freitas Oliveira Paranhos
PURPOSE: To evaluate two denture cleansers for overnight soaking (0.5% sodium hypochlorite and peroxide alkaline) regarding efficacy against Candida spp. biofilms (randomized clinical trial) and their effects on the physical properties of a denture base acrylic resin simulating a period of 5 years of use (laboratory study). The Candida spp. were identified and their resistance to main antifungal agents was evaluated. METHODS: 32 complete denture wearers were instructed to brush their dentures three times a day and to soak them (≥8 hours) in: control - water (C); alkaline peroxide (AP); or 0...
April 2017: American Journal of Dentistry
https://www.readbyqxmd.com/read/29174600/hybrid-combinations-containing-natural-products-and-antimicrobial-drugs-that-interfere-with-bacterial-and-fungal-biofilms
#11
REVIEW
Susana A Zacchino, Estefanía Butassi, Estefanía Cordisco, Laura A Svetaz
BACKGROUND: Biofilms contribute to the pathogenesis of many chronic and difficult-to eradicate infections whose treatment is complicated due to the intrinsic resistance to conventional antibiotics. As a consequence, there is an urgent need for strategies that can be used for the prevention and treatment of biofilm-associated infections. The combination therapy comprising an antimicrobial drug with a low molecular weight (MW) natural product and an antimicrobial drug (antifungal or antibacterial) appeared as a good alternative to eradicate biofilms...
November 23, 2017: Phytomedicine: International Journal of Phytotherapy and Phytopharmacology
https://www.readbyqxmd.com/read/29174192/implementation-of-an-antimicrobial-stewardship-program-for-patients-with-febrile-neutropenia
#12
Bahar Madran, Şiran Keske, Gizem Tokça, Ebru Dönmez, Burhan Ferhanoğlul, Mustafa Çetiner, Nil Molinas Mandel, Önder Ergönül
BACKGROUND: We aimed to describe the effectiveness of our standardized protocol for febrile neutropenia (FN), which was targeted to minimize unintended outcomes and reduce antimicrobial consumption. METHODS: The study was performed in a private hospital with 300 beds. We included all adult hematologic and oncologic cancer inpatients admitted between January 1, 2015-December 31, 2015, and January 1, 2016-May 31, 2017. The outcomes of the study were fatality, infections, and adherence to the antimicrobial stewardship program (ASP)...
November 21, 2017: American Journal of Infection Control
https://www.readbyqxmd.com/read/29173641/microbial-biodiversity-of-sardinian-oleic-ecosystems
#13
Mario Santona, Maria Lina Sanna, Chiara Multineddu, Francesco Fancello, Sara Audije de la Fuente, Sandro Dettori, Severino Zara
The olives are rich in microorganisms that, during the extraction process may persist in the oils and can influence their physicochemical and sensory characteristics. In this work, and for the first time, we isolated and identified microbial species, yeast and bacteria, present during the production process in four Sardinian (Italy) oleic ecosystems. Among these varieties, we found that Nera di Gonnos was associated to the highest microbial biodiversity, which was followed by Bosana, Nocellara del Belice and Semidana...
April 2018: Food Microbiology
https://www.readbyqxmd.com/read/29170992/clinical-strains-of-lactobacillus-reduce-the-filamentation-of-candida-albicans-and-protect-galleria-mellonella-against-experimental-candidiasis
#14
Rodnei Dennis Rossoni, Marisol Dos Santos Velloso, Lívia Mara Alves Figueiredo, Carolina Pistille Martins, Antonio Olavo Cardoso Jorge, Juliana Campos Junqueira
Candida albicans is the most common human fungal pathogen and can grow as yeast or filaments, depending on the environmental conditions. The filamentous form is of particular interest because it can play a direct role in adherence and pathogenicity. Therefore, the purpose of this study was to evaluate the effects of three clinical strains of Lactobacillus on C. albicans filamentation as well as their probiotic potential in pathogen-host interactions via an experimental candidiasis model study in Galleria mellonella...
November 23, 2017: Folia Microbiologica
https://www.readbyqxmd.com/read/29166538/antimicrobial-photodynamic-therapy-associated-with-conventional-endodontic-treatment-a-clinical-and-molecular-microbiological-study
#15
Caroline C da Silva, Sérgio P Chaves Júnior, Gabriela L D Pereira, Karla B F C da Fontes, Lívia A A Antunes, Helvécio C C Póvoa, Leonardo S Antunes, Natalia L P Póvoa Iorio
This study evaluated antimicrobial photodynamic therapy (aPDT) as an adjunct to endodontic treatment. Ten uniradicular teeth (control group (CG)= 4 (2 and test group (TG)= 6) with primary endodontic infections, from both genders, between 17 and 65 years old, were analyzed. Microbiological samples were collected before and after chemical-mechanical instrumentation (CMI), after aPDT (for the TG), and after the removal of the temporary restorations (second session). In TG, the aPDT was performed with 100 μg/mL methylene blue and irradiated with low power laser (InGaAIP, 660 nm; 100 mW; 40 sec) with a fiber-coupled optical laser...
November 22, 2017: Photochemistry and Photobiology
https://www.readbyqxmd.com/read/29165510/-the-1-3-%C3%AE-d-glucan-in-critical-adult-patients-as-diagnostic-tool-for-invasive-candida-spp-infection-performance-evaluation
#16
Liliana Donato, Tamara González, Marilena Canales, Paulette Legarraga, Patricia García, Ricardo Rabagliati
BACKGROUND: Invasive fungal infections are important causes of morbimortality in critical patients. Most of these infections are caused by Candida spp. which diagnosis has important limitations. AIM: Initial evaluation of the utility of 1,3-β-D-glucan (BDG) as a diagnostic tool for invasive candida infections in critical patients. PATIENTS AND METHODS: Adult patients over 18 years old, hospitalized in intensive care units for more than five days, with fever > 38 °C of unclear origin and two or more risk factors for invasive Candida spp...
August 2017: Revista Chilena de Infectología: órgano Oficial de la Sociedad Chilena de Infectología
https://www.readbyqxmd.com/read/29160517/prevalence-and-antibiogram-of-methicillin-resistant-staphylococcus-aureus-isolated-from-medical-device-related-infections-a-retrospective-study-in-lahore-pakistan
#17
Muhammad Sohail, Zakia Latif
INTRODUCTION: With the advancement of medicine and surgery, various types of medical devices have become part of treatment strategies. METHODS: Identification and antimicrobial sensitivity testing were done according to CLSI guidelines following standard microbiological practices. RESULTS: Urinary catheter infections (31%) were most frequent followed by central venous catheter (18%) and orthopedic implants (15%). Methicillin resistant Staphylococcus aureus (MRSA) was a major cause of device-related infection after Escherichia coli (21%); other pathogens were Klebsiella pneumoniae (14%), Pseudomonas spp...
September 2017: Revista da Sociedade Brasileira de Medicina Tropical
https://www.readbyqxmd.com/read/29156243/isolation-identification-and-selection-of-antagonistic-yeast-against-alternaria-alternata-infection-and-tenuazonic-acid-production-in-wine-grapes-from-argentina
#18
Luciana P Prendes, María G Merín, Ariel R Fontana, Rubén A Bottini, María L Ramirez, Vilma I Morata de Ambrosini
Epiphytic isolates with yeast characteristics from grapes of the Malbec cultivar were obtained in order to find antagonists against Alternaria alternata. From a total of 111 isolates, 82% corresponded to the yeast-like organism Aureobasidium pullulans and the rest to the non-Saccharomyces yeasts Hanseniaspora uvarum (6.3%), Metschnikowia pulcherrima or spp. (5.4%), Cryptoccocus laurentti II (2.7%), Starmerella bacilaris or Candida zemplinina (2.7%) and Rhodotorula spp. (0.9%). The 22.4% (15 out of 67) of epiphytic yeasts and yeast-like organisms evaluated were able to reduce A...
November 8, 2017: International Journal of Food Microbiology
https://www.readbyqxmd.com/read/29149978/perioperative-prophylaxis-for-total-artificial-heart-transplantation
#19
H E Chambers, P Pelish, F Qiu, D F Florescu
BACKGROUND: Practice variation regarding perioperative antimicrobial prophylaxis in total artificial heart transplantations (TAH-t) across institutions is unknown. The aim of our survey was to assess the current practices for prevention of infection in TAH-t recipients among different programs. METHODS: An electronic survey was sent to programs that implant Syncardia TAH (Syncardia Systems, Tuscon, Ariz, USA). Proportions were analyzed for categorical variables; means and SDs were analyzed for continuous variables...
November 2017: Transplantation Proceedings
https://www.readbyqxmd.com/read/29147977/are-isomeric-alkenes-used-in-species-recognition-among-neo-tropical-stingless-bees-melipona-spp
#20
Stephen J Martin, Sue Shemilt, Cândida B da S Lima, Carlos A L de Carvalho
Our understanding of the role of cuticular hydrocarbons (CHC) in recognition is based largely on temperate ant species and honey bees. The stingless bees remain relatively poorly studied, despite being the largest group of eusocial bees, comprising more than 400 species in some 60 genera. The Meliponini and Apini diverged between 80-130 Myr B.P. so the evolutionary trajectories that shaped the chemical communication systems in ants, honeybees and stingless bees may be very different. The aim of this study was to study if a unique species CHC signal existed in Neotropical stingless bees, as has been shown for many temperate species, and what compounds are involved...
November 17, 2017: Journal of Chemical Ecology
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