keyword
https://read.qxmd.com/read/38535591/antifungal-susceptibility-of-saccharomyces-cerevisiae-isolated-from-clinical-specimens
#1
JOURNAL ARTICLE
Aleksandra Górzyńska, Kamila Kondracka, Agnieszka Korzeniowska-Kowal, Urszula Nawrot
(1) Background: Despite being considered a non-pathogenic yeast, recently, a growing occurrence of Saccharomyces cerevisiae infections has been noted. There is little knowledge about the drug susceptibility of this species. Therefore, the objective of this research was to expand it and determine the drug susceptibility profile of a local collection of clinical isolates of this species. (2) Methods: This study contained 55 clinical isolates identified as Saccharomyces cerevisiae using the MALDI-TOF method. The susceptibility of Saccharomyces cerevisiae was tested to 10 antifungals (amphotericin B, flucytosine, fluconazole, voriconazole, posaconazole, micafungin, anidulafungin, caspofungin, and itraconazole) using MICRONAUT-AT tests and manogepix, a new drug, using the microdilution method according to EUCAST...
March 14, 2024: Pathogens
https://read.qxmd.com/read/38535222/commercial-methods-for-antifungal-susceptibility-testing-of-saprophytic-molds-can-they-be-used-to-detect-resistance
#2
REVIEW
Paschalis Paranos, Ana Espinel-Ingroff, Joseph Meletiadis
Commercial tests are often employed in clinical microbiology laboratories for antifungal susceptibility testing of filamentous fungi. Method-dependent epidemiological cutoff values (ECVs) have been defined in order to detect non-wild-type (NWT) isolates harboring resistance mechanisms. We reviewed the literature in order to find studies where commercial methods were used to evaluate for in vitro susceptibility of filamentous fungi and assess their ability to detect NWT isolates according to the available ECVs...
March 14, 2024: Journal of Fungi (Basel, Switzerland)
https://read.qxmd.com/read/38535202/changing-epidemiology-of-clinical-isolates-of-candida-species-during-the-coronavirus-disease-2019-pandemic-data-analysis-from-a-korean-tertiary-care-hospital-for-6-years-2017-2022
#3
JOURNAL ARTICLE
Eun Jeong Won, Heungsup Sung, Mi-Na Kim
This study assessed the changes in Candida species distribution and antifungal susceptibility patterns during the coronavirus disease 2019 (COVID-19) pandemic compared with a pre-pandemic period in Korea. We retrospectively investigated the specimen, species type, and antifungal susceptibility of Candida isolates obtained between 2016 and 2022. Data between two periods were compared: 2016-2019 (pre-pandemic) and 2020-2022 (pandemic). We included 11,396 clinical isolates of Candida species (5137 isolates in the pre-pandemic and 6259 isolates in the pandemic)...
March 2, 2024: Journal of Fungi (Basel, Switzerland)
https://read.qxmd.com/read/38534634/fungal-endophthalmitis-clinical-characteristics-pathogens-and-factors-affecting-visual-outcome
#4
JOURNAL ARTICLE
Xiaoxia Li, Zhi Chen, Xiuwen Zhang, Zimei Zhou, Maureen Boost, Taomin Huang, Xingtao Zhou
AIMS: The aims of this study are to investigate the etiology, microbiological spectrum, and risk factors associated with visual outcomes of fungal endophthalmitis (FE) in a tertiary eye specialty hospital in Shanghai, China. METHODS: This was a retrospective, single-center case series. The clinical characteristics, etiology, microbiological spectrum, and management, as well as the visual outcomes, were analyzed. Logistic regression was used to analyze the factors related to visual outcomes...
February 20, 2024: Antibiotics
https://read.qxmd.com/read/38534143/triazole-resistance-in-aspergillus-fumigatu-s-isolated-from-a-tomato-production-environment-exposed-to-propiconazole
#5
JOURNAL ARTICLE
Alejandra M Jimenez Madrid, Raees A Paul, Francesca Rotondo, Loic Deblais, Gireesh Rajashekara, Sally A Miller, Melanie L Lewis Ivey
UNLABELLED: The emergence of azole-resistant Aspergillus fumigatus (AR Af ) across the world is an important public health concern. We sought to determine if propiconazole, a demethylase inhibitor (DMI) fungicide, exerted a selective pressure for AR Af in a tomato production environment following multiple exposures to the fungicide. A tomato field trial was established in 2019 and propiconazole was applied weekly until harvest. Soil, leaf, and fruit (when present) samples were collected at baseline and after each propiconazole application...
March 27, 2024: Applied and Environmental Microbiology
https://read.qxmd.com/read/38533460/the-first-case-of-subcutaneous-mycosis-caused-by-muyocopron-laterale-in-china
#6
Tingting Yang, Yikan Ding, Yajie Fu, Hongchao Chen
Muyocopron laterale is a type of endophytic fungus that parasitizes monocotyledonous plants. Cases of humans and other mammals being infected by M. laterale are very rare around the world. We report the first case of subcutaneous mycosis caused by M. laterale in China. A kidney transplant recipient was admitted for Pneumocystis carinii pneumonia and subsequently developed left calf redness and swelling due to a M. laterale infection. The patient was treated with sulfamethoxazole and voriconazole and underwent five surgical debridements and vacuum sealing drainage (VSD) applications with the left leg...
March 2024: Medical Mycology Case Reports
https://read.qxmd.com/read/38530175/voriconazole-induced-periostitis-in-a-patient-after-orthotopic-liver-transplantation
#7
JOURNAL ARTICLE
Pokhraj Prakashchandra Suthar, Sumeet Virmani
No abstract text is available yet for this article.
March 2024: Radiology
https://read.qxmd.com/read/38527834/-clinical-features-and-risk-factors-for-invasive-fungal-sinusitis-after-allogeneic-hematopoietic-stem-cell-transplantation
#8
JOURNAL ARTICLE
H X Fu, J J Li, Y Y Zhang, Y Q Sun, X D Mo, T T Han, J Kong, M Lyu, W Han, H Chen, Y Y Chen, F R Wang, C H Yan, Y Chen, J Z Wang, Y Wang, L P Xu, X J Huang, X H Zhang
Objective: To analyze the clinical characteristics and outcomes of patients with invasive fungal sinusitis (invasive fungal rhinosinusitis, IFR) after allogeneic hematopoietic stem cell transplantation (allo-HSCT) and explored the risk factors for IFR after allo-HSCT. Methods: Nineteen patients with IFR after allo-HSCT at Peking University People's Hospital from January 2012 to December 2021 were selected as the study group, and 95 patients without IFR after allo-HSCT during this period were randomly selected as the control group (1:5 ratio) ...
January 14, 2024: Zhonghua Xue Ye Xue za Zhi, Zhonghua Xueyexue Zazhi
https://read.qxmd.com/read/38524068/antifungal-susceptibility-profile-of-clinical-and-environmental-isolates-of-aspergillus-species-from-a-tertiary-care-center-in-north-india
#9
JOURNAL ARTICLE
Manharpreet Kaur, Nidhi Singla, Deepak Aggarwal, Reetu Kundu, Neelam Gulati, Mani Bhushan Kumar, Satinder Gombar, Jagdish Chander
INTRODUCTION: Aspergillus species are ubiquitously found in the environment worldwide and are important causative agents for infection. Drug resistance among Aspergillus species is emerging, hence the present study was undertaken to look for antifungal susceptibility profiles of clinical and environmental isolates of Aspergillus species. MATERIALS AND METHODS: During the period from January 2018 to June 2019, a total of 102 Aspergillus isolates (40 clinical, 40 hospital, and 22 community environment) were tested for antifungal susceptibility testing for determination of minimum inhibitory concentration (MIC)/minimum effective concentration (MEC) as per Clinical and Laboratory Standards Institute (CLSI) M38-A3 method for itraconazole, voriconazole, amphotericin B, and caspofungin...
February 2024: Curēus
https://read.qxmd.com/read/38519827/a-case-of-lomentospora-prolificans-endophthalmitis-treated-with-the-novel-antifungal-agent-olorofim
#10
JOURNAL ARTICLE
Michael Dong, Fiona Pearce, Nandini Singh, Ming-Lee Lin
PURPOSE: To report a case of endogenous Lomentospora prolificans endophthalmitis treated with the novel antifungal agent Olorofim. CASE REPORT: A 57-year-old man developed disseminated Lomentospora prolificans with right endophthalmitis on the background of immunosuppression following lung transplantation for interstitial lung disease. He was treated with early vitrectomy, intravitreal voriconazole, and systemic Olorofim, voriconazole and terbinafine. His symptoms improved and remained stable in the right eye...
March 22, 2024: Journal of Ophthalmic Inflammation and Infection
https://read.qxmd.com/read/38515075/a-systemic-infection-involved-in-lung-brain-and-spine-caused-by-scedosporium-apiospermum-species-complex-after-near-drowning-a-case-report-and-literature-review
#11
REVIEW
Peng Yan, Junfeng Chen, Haodi Wang, Qi Jia, Jungang Xie, Guoxin Mo
Scedosporium apiospermum species complex are widely distributed fungi that can be found in a variety of polluted environments, including soil, sewage, and decaying vegetation. Those opportunistic pathogens with strong potential of invasion commonly affect immunosuppressed populations However, few cases of scedosporiosis are reported in immunocompetent individuals, who might be misdiagnosed, leading to a high mortality rate. Here, we reported an immunocompetent case of systemtic infection involved in lung, brain and spine, caused by S...
March 21, 2024: BMC Infectious Diseases
https://read.qxmd.com/read/38509398/anti-fungal-effects-of-novel-n-tert-butyl-2-pyridin-2-yl-imidazo-1-2-a-pyridin-3-amine-derivative-and-it-s-in-vitro-in-silico-and-mode-of-action-against-candida-spp
#12
JOURNAL ARTICLE
Manivannan Nandhagopal, Ramanjaneyulu Mala, Kanagasabai Somarathinam, Divya Dhakshinamurthy, Mathivanan Narayanasamy, Priyadharshni Vijayan, Manimuthu Mani Shankar
Imidazoles are a category of azole antifungals that encompass compounds such as ketoconazole, miconazole, esomeprazole, and clotrimazole. In contrast, the triazoles group, which includes fluconazole, voriconazole, and itraconazole, also plays a significant role. The rise of antibiotic resistance in fungal pathogens has evolved into a substantial global public health concern. In this study, two newly synthesized imidazo[1,2-a]pyridine derivative (Probe I and Probe II) molecules were investigated for its antimicrobial potency against of a panel of bacterial (Gram-positive and Gram-negative bacteria) and fungal pathogens...
March 21, 2024: Archives of Microbiology
https://read.qxmd.com/read/38507825/acquired-resistance-or-tolerance-in-search-of-mechanisms-underlying-changes-in-the-resistance-profile-of-candida-albicans-and-candida-parapsilosis-as-a-result-of-exposure-to-methotrexate
#13
JOURNAL ARTICLE
Katarzyna Góralska, Małgorzata Szybka, Filip Franciszek Karuga, Dorota Pastuszak-Lewandoska, Ewa Brzeziańska-Lasota
The increasing prevalence of fungal strains showing acquired resistance and multidrug resistance is an increasing therapeutic problem, especially in patients with a severely weakened immune system and undergoing chemotherapy. What is also extremely disturbing is the similarity of the resistance mechanisms of fungal cells and other eukaryotic cells, including human cells, which may contribute to the development of cross-resistance in fungi in response to substances used in e.g. anticancer treatment. An example of such a drug is methotrexate, which is pumped out of eukaryotic cells by ABC transmembrane transporters - in fungi, used to remove azoles from fungal cells...
March 15, 2024: Journal de Mycologie Médicale
https://read.qxmd.com/read/38501836/evaluation-of-the-vitek-2-system-for-antifungal-susceptibility-testing-of-candida-auris-using-a-representative-international-panel-of-clinical-isolates-overestimation-of-amphotericin-b-resistance-and-underestimation-of-fluconazole-resistance
#14
JOURNAL ARTICLE
Maria Siopi, Ioannis Pachoulis, Sevasti Leventaki, Bram Spruijtenburg, Jacques F Meis, Spyros Pournaras, Georgia Vrioni, Athanasios Tsakris, Joseph Meletiadis
Although the Vitek 2 system is broadly used for antifungal susceptibility testing of Candida spp., its performance against Candida auris has been assessed using limited number of isolates recovered from restricted geographic areas. We therefore compared Vitek 2 system with the reference Clinical and Laboratory Standards Institute (CLSI) broth microdilution method using an international collection of 100 C . auris isolates belonging to different clades. The agreement ±1 twofold dilution between the two methods and the categorical agreement (CA) based on the Centers for Disease Control and Prevention's (CDC's) tentative resistance breakpoints and Vitek 2-specific wild-type upper limit values (WT-ULVs) were determined...
March 19, 2024: Journal of Clinical Microbiology
https://read.qxmd.com/read/38500954/diagnosis-of-pulmonary-hemorrhagic-leptospirosis-complicated-by-invasive-pulmonary-aspergillosis-complemented-by-metagenomic-next-generation-sequencing-a-case-report
#15
Qiong-Fang Yang, Cai-Min Shu, Qiao-Ying Ji
BACKGROUND: Leptospirosis is a bacterial zoonosis with variable clinical manifestations. Pulmonary diffuse hemorrhagic leptospirosis often occurs rapidly and, when not promptly diagnosed and treated, it can be life-threatening. Aspergillus flavus is an opportunistic fungus that is commonly seen in immunosuppressed patients. Invasive pulmonary aspergillosis also progresses rapidly. This case study describes a patient with severe pneumonia caused by pulmonary hemorrhagic leptospirosis combined with invasive pulmonary aspergillosis...
2024: Frontiers in Medicine
https://read.qxmd.com/read/38500519/factors-influencing-voriconazole-plasma-level-in-intensive-care-patients
#16
JOURNAL ARTICLE
Christopher Alexander Hinze, Jan Fuge, Denis Grote-Koska, Korbinian Brand, Hortense Slevogt, Markus Cornberg, Susanne Simon, Oana Joean, Tobias Welte, Jessica Rademacher
BACKGROUND: In clinical routine, voriconazole plasma trough levels ( C min ) out of target range are often observed with little knowledge about predisposing influences. OBJECTIVES: To determine the distribution and influencing factors on voriconazole blood levels of patients treated on intensive- or intermediate care units (ICU/IMC). PATIENTS AND METHODS: Data were collected retrospectively from patients with at least one voriconazole trough plasma level on ICU/IMC ( n  = 153) to determine the proportion of sub-, supra- or therapeutic plasma levels...
April 2024: JAC-antimicrobial resistance
https://read.qxmd.com/read/38490708/nodular-lesions-of-the-buttock-for-20-years-the-challenge-of-chromoblastomycosis-in-non-endemic-settings
#17
JOURNAL ARTICLE
William Osborne, Gerald Langman, Evmorfia Ladoyanni, Amy Chue
Chromoblastomycosis is an implantation mycosis of the skin caused by certain species of melanised fungi. A man in his 50s, born in Kerala but living in England for 14 years, presented with a nodular lesion on his left buttock, which had been present for 20 years. Biopsy revealed muriform cells and fungal culture isolated Fonsecaea spp , consistent with a diagnosis of chromoblastomycosis. Treatment with oral terbinafine was initiated and changed to itraconazole based on results of antifungal susceptibility. Drug intolerance and low drug levels of itraconazole necessitated change to voriconazole and topical terbinafine...
March 15, 2024: BMJ Case Reports
https://read.qxmd.com/read/38487405/long-term-survival-following-medical-management-of-aspergillus-endocarditis-with-dissemination-as-a-consequence-of-steroid-therapy-in-severe-covid-19-pneumonia
#18
Kiran G Kulirankal, Ann Mary, Merlin Moni, Gopal S Pillai, Dipu T Sathyapalan
A male in his 40's with no known comorbidities developed severe COVID-19 pneumonia and received a four-week course of methylprednisolone. The patient subsequently developed disseminated Aspergillus endocarditis, manifesting as multiple organ involvement including the heart, eyes, and brain. Despite the poor prognosis generally associated with fungal endocarditis, the patient survived following aggressive medical management with a combination of liposomal amphotericin b and voriconazole therapy and is now doing well for over two years and is off antifungal therapy for a year...
March 2024: Medical Mycology Case Reports
https://read.qxmd.com/read/38486086/cyp51a-mutations-protein-modeling-and-efflux-pump-gene-expression-reveals-multifactorial-complexity-towards-understanding-aspergillus-section-nigri-azole-resistance-mechanism
#19
JOURNAL ARTICLE
Pooja Sen, Mukund Vijay, Himanshu Kamboj, Lovely Gupta, Jata Shankar, Pooja Vijayaraghavan
Black Aspergillus species are the most common etiological agents of otomycosis, and pulmonary aspergillosis. However, limited data is available on their antifungal susceptibility profiles and associated resistance mechanisms. Here, we determined the azole susceptibility profiles of black Aspergillus species isolated from the Indian environment and explored the potential resistance mechanisms through cyp51A gene sequencing, protein homology modeling, and expression analysis of selected genes cyp51A, cyp51B, mdr1, and mfs based on their role in imparting resistance against antifungal drugs...
March 14, 2024: Scientific Reports
https://read.qxmd.com/read/38483637/resistance-profile-terbinafine-resistance-screening-and-maldi-tof-ms-identification-of-the-emerging-pathogen-trichophyton-indotineae
#20
JOURNAL ARTICLE
Roelke De Paepe, Anne-Cécile Normand, Silke Uhrlaß, Pietro Nenoff, Renaud Piarroux, Ann Packeu
The emerging pathogen Trichophyton indotineae, often resistant to terbinafine (TRB), is known to cause severe dermatophytoses such as tinea corporis and tinea cruris. In order to achieve successful treatment for these infections, insight in the resistance profile of T. indotineae strains and rapid, reliable identification is necessary. In this research, a screening medium was tested on T. indotineae strains (n = 20) as an indication tool of TRB resistance. The obtained results were confirmed by antifungal susceptibility testing (AST) for TRB following the in vitro broth microdilution reference method...
March 14, 2024: Mycopathologia
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