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https://www.readbyqxmd.com/read/29475213/modified-multivisceral-transplantation-with-native-spleen-removal-in-rats
#1
Pablo Stringa, Nidia Monserrat Arreola, Ane M Andres Moreno, Carlota Largo, Martín Rumbo, Francisco Hernandez
BACKGROUND:  Modified multivisceral transplantation (MMVTx) refers to the use of a graft that includes all abdominal organs except the liver. The use of this type of transplant in children and adults expanded over the last years with good results. However, long-term survival in experimental models has not been reported. Our aim is to describe in detail some technical modifications of MMVTx to obtain long-term survival. MATERIALS AND METHODS:  Syngeneic (Lewis-Lewis) heterotopic MMVTx was performed in 16 male rats (180-250 g)...
February 23, 2018: European Journal of Pediatric Surgery
https://www.readbyqxmd.com/read/29474954/orexin-1-and-orexin-2-receptor-antagonism-in-the-basolateral-amygdala-modulate-long-term-potentiation-of-the-population-spike-in-the-perforant-path-dentate-gyrus-evoked-field-potential-in-rats
#2
Motahareh Rouhi Ardeshiri, Narges Hosseinmardi, Esmaeil Akbari
Involvement of amygdalo-hippocampal substructures in patients with narcolepsy due to deficiencies in the orexinergic system, and the presence of hippocampus-dependent memory impairments in this disorder, have led us to investigate the effects of orexin 1 and 2 receptor antagonism in the basolateral amygdala (BLA) on long-term potentiation (LTP) of dentate gyrus (DG) granular cells. We used a 200-Hz high-frequency stimulation protocol in anesthetized rats. We studied the long-term synaptic plasticity of perforant path-dentate gyrus granule cells following the inactivation of orexin receptors before and after tetanic stimulation...
February 20, 2018: Neurobiology of Learning and Memory
https://www.readbyqxmd.com/read/29474950/remineralisation-of-enamel-white-spot-lesions-pre-treated-with-chitosan-in-the-presence-of-salivary-pellicle
#3
Jing Zhang, Richard J M Lynch, Timothy F Watson, Avijit Banerjee
OBJECTIVE: To investigate the remineralisation of chitosan pre-treated enamel white spot lesions (WSLs) by bioglass in the presence of the pellicle layer. METHODS: 50 artificial enamel white spot lesions were created by acidic gel. Two lesions were used to investigate the formation of the pellicle layer by treating with human whole saliva for 3 minutes. 48 lesions were assigned to 6 experimental groups (n = 8): (1) bioactive glass slurry, (2) bioactive glass containing polyacrylic acid (BG + PAA) slurry, (3) chitosan pre-treated WSLs with BG slurry (CS-BG), (4) chitosan pre-treated WSLs with BG + PAA slurry (CS-BG + PAA), (5) "standard" remineralisation solution (RS) and (6) de-ionised water (negative control, NC)...
February 20, 2018: Journal of Dentistry
https://www.readbyqxmd.com/read/29474897/aqueous-injection-of-quercetin-an-approach-for-confirmation-of-its-direct-in-vivo-cardiovascular-effects
#4
Elena Piera Porcu, Massimo Cossu, Giovanna Rassu, Paolo Giunchedi, Guido Cerri, Jana Pourová, Iveta Najmanová, Thomas Migkos, Veronika Pilařová, Lucie Nováková, Přemysl Mladěnka, Elisabetta Gavini
Potential positive effects of flavonol quercetin on humans were suggested by many studies. However, it is not clear if these effects are mediated by quercetin or its metabolites. The in vivo confirmation of quercetin effects is largely hindered by its low water solubility and thus impossibility to test directly its impact. Therefore, a solid dispersion of quercetin with polyvinylpyrrolidone (PVP) was developed to prepare an injectable formulation of water-soluble quercetin. The optimized formulation provided a 20,000-fold increase in quercetin solubility...
February 20, 2018: International Journal of Pharmaceutics
https://www.readbyqxmd.com/read/29474816/coffee-for-cardioprotection-and-longevity
#5
REVIEW
James H O'Keefe, James J DiNicolantonio, Carl J Lavie
Coffee, a complex brew containing hundreds of biologically active compounds, exerts potent effects on long-term human health. Recently, a plethora of studies have been published focusing on health outcomes associated with coffee intake. An inverse association between coffee consumption and all-cause mortality has been seen consistently in large prospective studies. Habitual coffee consumption is also associated with lower risks for cardiovascular (CV) death and a variety of adverse CV outcomes, including coronary heart disease (CHD), congestive heart failure (HF), and stroke; coffee's effects on arrhythmias and hypertension are neutral...
February 20, 2018: Progress in Cardiovascular Diseases
https://www.readbyqxmd.com/read/29474811/evaluation-of-behavioral-parameters-hematological-markers-liver-and-kidney-functions-in-rodents-exposed-to-deepwater-horizon-crude-oil-and-corexit
#6
Sindhu Ramesh, Dwipayan Bhattacharya, Mohammed Majrashi, Marlee Morgan, T Prabhakar Clement, Muralikrishnan Dhanasekaran
The 2010 Deepwater Horizon (DWH) oil spill is the largest marine oil spill in US history. In the aftermath of the spill, the response efforts used a chemical dispersant, Corexit, to disperse the oil spill. The health impacts of crude oil and Corexit mixture to humans, mammals, fishes, and birds are mostly unknown. The purpose of this study is to investigate the in vivo effects of DWH oil, Corexit, and oil-Corexit mixture on the general behavior, hematological markers, and liver and kidney functions of rodents...
February 20, 2018: Life Sciences
https://www.readbyqxmd.com/read/29474550/developmental-plasticity-and-its-relevance-to-assisted-human-reproduction
#7
Tessa J Roseboom
The advent of assisted reproduction has allowed the conception of millions of individuals who otherwise would not have existed. Although most ART children are born healthy, there is increasing awareness of the plasticity of the human embryo causing concerns about potential long-term consequences of ART for the growth, development and health of this growing population of individuals. Evidence from studies in animals and humans suggest that physiology and metabolism may be permanently affected by ART. It suggests that ART children may be at increased risk of later cardiometabolic diseases...
February 21, 2018: Human Reproduction
https://www.readbyqxmd.com/read/29474450/treatment-with-native-heterodimeric-il-15-increases-cytotoxic-lymphocytes-and-reduces-shiv-rna-in-lymph-nodes
#8
Dionysios C Watson, Eirini Moysi, Antonio Valentin, Cristina Bergamaschi, Santhi Devasundaram, Sotirios P Fortis, Jenifer Bear, Elena Chertova, Julian Bess, Ray Sowder, David J Venzon, Claire Deleage, Jacob D Estes, Jeffrey D Lifson, Constantinos Petrovas, Barbara K Felber, George N Pavlakis
B cell follicles in secondary lymphoid tissues represent an immune privileged sanctuary for AIDS viruses, in part because cytotoxic CD8+ T cells are mostly excluded from entering the follicles that harbor infected T follicular helper (TFH) cells. We studied the effects of native heterodimeric IL-15 (hetIL-15) treatment on uninfected rhesus macaques and on macaques that had spontaneously controlled SHIV infection to low levels of chronic viremia. hetIL-15 increased effector CD8+ T lymphocytes with high granzyme B content in blood, mucosal sites and lymph nodes, including virus-specific MHC-peptide tetramer+ CD8+ cells in LN...
February 2018: PLoS Pathogens
https://www.readbyqxmd.com/read/29474299/descemet-membrane-endothelial-keratoplasty-dmek-under-previous-dmek-for-secondary-endothelial-graft-failure
#9
Jorge L Alió Del Barrio, Alfredo Vega-Estrada, Jorge L Alió
PURPOSE: To describe an alternative treatment option for secondary Descemet membrane endothelial keratoplasty (DMEK) graft failure, using a second DMEK graft without primary graft removal ("DMEK under DMEK"). METHODS: A 72-year-old patient with pseudophakic bullous keratopathy in the left eye underwent an 8.25-mm second DMEK under an 8.5-mm failed DMEK because of previous graft rejection and subsequent secondary failure. RESULTS: Corrected distance visual acuity improved from 0...
February 22, 2018: Cornea
https://www.readbyqxmd.com/read/29474202/a-decade-long-clinical-experience-on-the-prophylactic-use-of-activated-prothrombin-complex-concentrate-in-acquired-haemophilia-a-a-case-series-from-a-tertiary-care-centre
#10
Anita Árokszállási, Katalin Rázsó, Péter Ilonczai, Zsolt Oláh, Zsuzsanna Bereczky, Zoltán Boda, Ágota Schlammadinger
: In acquired haemophilia A (AHA), risk for recurrent bleeding exists until the inhibitor is detectable. Thus, patients with persisting inhibitor may benefit from prophylaxis with activated prothrombin complex concentrate (aPCC). Potential thromboembolic complications and cost are also factors to consider. Today, no high level evidence or clear recommendations are available on aPCC prophylaxis in AHA. Recently, a small prospective study demonstrated a favourable outcome with short-term, daily administered aPCC infusion...
February 22, 2018: Blood Coagulation & Fibrinolysis: An International Journal in Haemostasis and Thrombosis
https://www.readbyqxmd.com/read/29473979/a-novel-glp-1-gip-gcg-triagonist-reduces-cognitive-deficits-and-pathology-in-the-3xtg-mouse-model-of-alzheimer-s-disease
#11
Tian Li, Juan-Juan Jiao, Christian Hölscher, Mei-Na Wu, Jun Zhang, Jia-Qing Tong, Xue-Fan Dong, Xue-Song Qu, Yue Cao, Hong-Yan Cai, Qiang Su, Jin-Shun Qi
Type 2 diabetes mellitus (T2DM) is an important risk factor for Alzheimer's disease (AD). Glucagon-like peptide-1 (GLP-1) and glucose-dependent insulinotropic polypeptide (GIP) have been identified to be effective in T2DM treatment and neuroprotection. In the present study, we further explored the effects of a novel unimolecular GLP-1/GIP/Gcg triagonist on the cognitive behavior and cerebral pathology in the 7-month-old triple transgenic mouse model of AD (3xTg-AD), and investigated its possible electrophysiological and molecular mechanisms...
February 23, 2018: Hippocampus
https://www.readbyqxmd.com/read/29473936/differential-survivorship-of-congeneric-ornamental-fishes-under-forecasted-climate-changes-are-related-to-anaerobic-potential
#12
Luciana Mara Fé Gonçalves, Maria de Nazaré Paula da Silva, Adalberto Luis Val, Vera Maria Fonseca de Almeida-Val
Two Amazonian closely related tetras - cardinal Paracheirodon axelrodi and green neon P. simulans - were artificially acclimatized to environmental chambers mimicking future climate change scenarios (mild, moderate and extreme), using a microcosm facility. P. simulans survived (100%) to all scenarios after 30 days exposure, while P. axelrodi presented decreasing survival percentages according to environmental severity. These differences may be the reflection of distinct natural acclimatization to microhabitats between the species, which differ in thermal conditions...
February 19, 2018: Genetics and Molecular Biology
https://www.readbyqxmd.com/read/29473909/assessment-of-pressure-sources-and-water-body-resilience-an-integrated-approach-for-action-planning-in-a-polluted-river-basin
#13
Domenica Mirauda, Marco Ostoich
The present study develops an integrated methodology combining the results of the water-quality classification, according to the Water Framework Directive 2000/60/EC-WFD, with those of a mathematical integrity model. It is able to analyse the potential anthropogenic impacts on the receiving water body and to help municipal decision-makers when selecting short/medium/long-term strategic mitigation actions to be performed in a territory. Among the most important causes of water-quality degradation in a river, the focus is placed on pollutants from urban wastewater...
February 23, 2018: International Journal of Environmental Research and Public Health
https://www.readbyqxmd.com/read/29473837/graduate-medical-education-funding-and-curriculum-in-physical-medicine-and-rehabilitation-a-survey-of-physical-medicine-and-rehabilitation-department-chairs
#14
Danielle Perret, Tiffany Knowlton, Gregory Worsowicz
This national survey highlights graduate medical education funding sources for physical medicine and rehabilitation (PM&R) residency programs as well as perceived funding stability, alignment of the current funding and educational model, the need of further education in postacute care settings, and the practice of contemporary PM&R graduates as perceived by PM&R department/division chairs. Approximately half of the reported PM&R residency positions seem to be funded by Centers of Medicare and Medicaid Services; more than 40% of PM&R chairs believe that their residency program is undersized and nearly a quarter feel at risk for losing positions...
March 2018: American Journal of Physical Medicine & Rehabilitation
https://www.readbyqxmd.com/read/29473737/optofluidic-sensor-for-inline-hemolysis-detection-on-whole-blood
#15
Chen Zhou, Mehdi Keshavarz Hedayati, Xiaolong Zhu, Frank Nielsen, Uriel Levy, Anders Kristensen
Hemolysis is the rupture of red blood cells and constitutes the most common reason for unsuitable blood samples in the clinic. To detect hemolysis, one has to separate the hemoglobin in blood plasma from that in red blood cells. However, current methods entail centrifugation for cell-plasma separation, which is complex, time-consuming, and not easy to integrate into point-of-care (PoC) systems. Here, we demonstrate an optofluidic sensor composed of nanofilters on an optical waveguide, which enables evanescent-wave absorption measurement of hemoglobin in plasma with the capability of real-time inline detection on whole blood without extra sample preparation like centrifugation...
February 23, 2018: ACS Sensors
https://www.readbyqxmd.com/read/29473730/non-catalytic-endosialidase-enables-surface-capture-of-small-cell-lung-cancer-cells-utilizing-strong-dendrimer-mediated-enzyme-glycoprotein-interactions
#16
Hao-Jui Hsu, Helena Palka-Hamblin, Gaurang P Bhide, Ja Hye Myung, Michael Cheong, Karen J Colley, Seungpyo Hong
Enumeration of circulating tumor cells (CTCs) of small-cell lung cancer (SCLC) patients has been shown to predict the disease progress and long-term survival. Most CTC detection methods rely on epithelial surface markers, such as epithelial cell adhesion molecule (EpCAM). However, this marker in SCLC is reported to be often downregulated after a variety of phenotypic changes, which impairs the reliability of EpCAM-based CTC detections. In this regard, the development of an alternative CTC detection method involving different CTC surface markers is in demand...
February 23, 2018: Analytical Chemistry
https://www.readbyqxmd.com/read/29473452/a-new-surgical-device-for-anterograde-intraoperative-rectal-washout
#17
Fabio Rondelli, Roberto Santinelli, Paolo Stella, Walter Bugiantella, Graziano Ceccarelli, Ruben Carlo Balzarotti, Michele De Rosa, Nicola Avenia
BACKGROUND: Colorectal cancer is the fourth most diffuse cause of death in the world and local recurrence is associated with a reduced long-term life expectancy, with a reduced quality of life. Rectal washout at the anastomosis site leads to a statistically significant reduction of local recurrences. METHODS: We developed the idea of a new laparoscopic stapler with an integrated washout system that could decontaminate the rectal stump before resection, without the need to enlarge the standard surgical incision or even to distort the incision site, closing the rectal stump just below the inferior part of the cancer, and then proceeding with the resection and stapling of the distal part of the tumor...
February 1, 2018: Surgical Innovation
https://www.readbyqxmd.com/read/29473438/crispr-and-personalized-treg-therapy-new-insights-into-the-treatment-of-rheumatoid-arthritis
#18
Fatemeh Safari, Safar Farajnia, Maryam Arya, Habib Zarredar, Ava Nasrolahi
INTRODUCTION: Rheumatoid arthritis (RA), as one of the most disabling autoimmune diseases, is a common health problem that progressively reduces the life quality of patients. Although various biologics have been introduced for RA, attempts to establish an efficient long-term therapies failed due to the heterogeneity of this disease. METHODS: In the last decade, immunomodulatory approaches such as T cell adoptive therapy have been developed for controlling autoimmunity...
February 23, 2018: Immunopharmacology and Immunotoxicology
https://www.readbyqxmd.com/read/29473293/highly-sensitive-and-stretchable-resistive-strain-sensors-based-on-microstructured-metal-nanowire-elastomer-composite-films
#19
Kang-Hyun Kim, Nam-Su Jang, Sung-Hun Ha, Ji Hwan Cho, Jong-Man Kim
High sensitivity and high stretchability are two conflicting characteristics that are difficult to achieve simultaneously in elastic strain sensors. A highly sensitive and stretchable strain sensor comprising a microstructured metal nanowire (mNW)/elastomer composite film is presented. The surface structure is easily prepared by combining an mNW coating and soft-lithographic replication processes in a simple and reproducible manner. The densely packed microprism-array architecture of the composite film leads to a large morphological change in the mNW percolation network by efficiently concentrating the strain in the valley regions upon stretching...
February 23, 2018: Small
https://www.readbyqxmd.com/read/29473230/engineering-extracellular-vesicles-with-the-tools-of-enzyme-prodrug-therapy
#20
Gregor Fuhrmann, Rona Chandrawati, Paresh A Parmar, Timothy J Keane, Stephanie A Maynard, Sergio Bertazzo, Molly M Stevens
Extracellular vesicles (EVs) have recently gained significant attention as important mediators of intercellular communication, potential drug carriers, and disease biomarkers. These natural cell-derived nanoparticles are postulated to be biocompatible, stable under physiological conditions, and to show reduced immunogenicity as compared to other synthetic nanoparticles. Although initial clinical trials are ongoing, the use of EVs for therapeutic applications may be limited due to undesired off-target activity and potential "dilution effects" upon systemic administration which may affect their ability to reach their target tissues...
February 23, 2018: Advanced Materials
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