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https://www.readbyqxmd.com/read/29050258/the-diagnostic-prognostic-potential-and-molecular-functions-of-long-non-coding-rnas-in-the-exosomes-derived-from-the-bile-of-human-cholangiocarcinoma
#1
Xianxiu Ge, Youli Wang, Junjie Nie, Quanpeng Li, Lingyu Tang, Xueting Deng, Fei Wang, Boming Xu, Xiaochao Wu, Xiuhua Zhang, Qiang You, Lin Miao
Cholangiocarcinoma (CCA) is an aggressive malignancy associated with unfavorable prognosis, and it's difficult to diagnose and no effective treatments are available. Long non-coding RNAs (lncRNAs) play important roles in tumorigenesis and metastasis. Intact lncRNAs from exosomes have sparked much interest as potential biomarker for the non-invasive analysis of disease. Here, via exosome sequencing on lncRNAs, GO analysis, KEGG pathway and co-expression analysis, receiver operating characteristic curve and survival analyses, we found that, compared with control group, lncRNAs of ENST00000588480...
September 19, 2017: Oncotarget
https://www.readbyqxmd.com/read/29050211/silibinin-attenuates-radiation-induced-intestinal-fibrosis-and-reverses-epithelial-to-mesenchymal-transition
#2
Joong Sun Kim, Na-Kyung Han, Sung-Ho Kim, Hae-June Lee
Radiotherapy is a common treatment for cancer patients, but its use is often restricted by the tolerance of normal tissue. As cancer patients live longer, delayed radiation effects on normal tissue have become a concern. Radiation-induced enteropathy, including inflammatory bowel disease and fibrosis, are major issues for long-term cancer survivors. To investigate whether silibinin attenuates delayed radiation-induced intestinal injury in mice, we focused on intestinal fibrotic changes. Silibinin improved delayed radiation injuries in mice in association with decreased collagen deposition within the intestines and deceased transforming growth factor (TGF)-β1 levels in the intestine and plasma...
September 19, 2017: Oncotarget
https://www.readbyqxmd.com/read/29050089/-a-retrospective-analysis-of-co-2-laser-and-microdebrider-for-the-treatment-of-severe-juvenile-on-set-recurrent-respiratory-papillomatosis
#3
Q W Yang, W Xu, W Guo, W X Cui, Y R Li, X Y Wang, J Yang, X Y Li
Objective: Juvenile on-set recurrent respiratory papillomatosis (JORRP) can be an aggressive and potentially life-threatening disease. To emphasize the importance of complication prevention in local excision surgery, the single-center experience of RRP treatment in a group of patients with relatively short recurrence-free-interval (>4 times/yrs) was reported. Methods: Data of 49 patients underwent papilloma resection during 2002-2013 were retrospectively analyzed. Combined techniques of laser microsurgery and microdebriders were used to remove papillomas, prevent the formation of scar tissue and improve respiratory distress...
October 7, 2017: Zhonghua Er Bi Yan Hou Tou Jing Wai Ke za Zhi, Chinese Journal of Otorhinolaryngology Head and Neck Surgery
https://www.readbyqxmd.com/read/29050002/urinary-erythrocyte-derived-mirnas-emerging-role-in-iga-nephropathy
#4
Zhi-Yu Duan, Guang-Yan Cai, Ji-Jun Li, Ru Bu, Xiang-Mei Chen
Hematuria is one of the basic clinical manifestations of IgA nephropathy (IgAN). Isolated microscopic hematuria or microscopic hematuria combined with proteinuria is risk factor for the long-term prognosis of IgAN. Current evidence of the consequences of glomerular hematuria rests on insights from basic research on the molecular mechanisms of hemoglobin and related reactive oxygen species-induced tubular injury as well as on the clinical evidence of macroscopic hematuria-associated acute kidney injury (AKI) in IgAN...
October 19, 2017: Kidney & Blood Pressure Research
https://www.readbyqxmd.com/read/29049907/clinical-correlates-of-saccadic-eye-movement-in-antipsychotic-na%C3%A3-ve-schizophrenia
#5
Aditi Subramaniam, Vijay Danivas, Sri Mahavir Agarwal, Sunil Kalmady, Venkataram Shivakumar, Anekal C Amaresha, Anushree Bose, Janardhanan C Narayanaswamy, Shivarama Varambally, Samuel B Hutton, Ganesan Venkatasubramanian, Bangalore N Gangadhar
Some aspects of saccadic performance have been found to be abnormal in chronic schizophrenia. The majority of this research has, however, been performed on patients treated with long-term antipsychotic medication. Very few studies have examined saccadic performance in antipsychotic-naïve/free patients. There are also very few studies describing the relationship between saccadic performance and clinical symptoms, particularly in antipsychotic free patients. In this study, we compared pro and antisaccade performance in a large sample of antipsychotic-naïve/free schizophrenia patients (N = 45) with healthy controls (N = 57)...
October 4, 2017: Psychiatry Research
https://www.readbyqxmd.com/read/29049549/transapical-cardioscopic-mitral-annuloplasty-a-short-term-survival-study-in-a-porcine-model
#6
Thang Duc Vu, Min Zin Oo, Duc-Viet Nguyen, Ervin Marquez Ocampo, Yilin Ong, Suganya Cheyyatraivendran-Arularasu, Lian-Kah Ti, Mark A Richards, Theo Kofidis
OBJECTIVES: The transapical approach provides concurrent surgical access to the mitral and the aortic valves, the root of the aorta and the left atrium. We previously showed the feasibility of transapical cardioscopic (TAC) surgery in a non-survival porcine model. However, reproducibility and feasibility of ring implantation using TAC have not been reported. Therefore, in this study, we hypothesized that implantation of a mitral annuloplasty ring can be feasibly and safely carried out endoscopically via the apex of the heart...
August 30, 2017: Interactive Cardiovascular and Thoracic Surgery
https://www.readbyqxmd.com/read/29049517/-job-lock-among-long-term-survivors-of-childhood-cancer-a-report-from-the-childhood-cancer-survivor-study
#7
Anne C Kirchhoff, Ryan Nipp, Echo L Warner, Karen Kuhlthau, Wendy M Leisenring, Karen Donelan, Julia Rabin, Giselle K Perez, Kevin C Oeffinger, Paul C Nathan, Leslie L Robison, Gregory T Armstrong, Elyse R Park
Importance: Childhood cancer survivors may be reluctant to make changes in their employment because of access to health insurance. Objective: To examine the prevalence of "job lock" (staying at a job to keep work-related health insurance) in a sample drawn from an established, multi-institutional cohort of full-time employed childhood cancer survivors compared with a random sample of siblings and to explore factors associated with job lock among cancer survivors...
October 19, 2017: JAMA Oncology
https://www.readbyqxmd.com/read/29049189/the-prevalence-and-long-term-variation-of-hospital-readmission-for-patients-with-diabetes-in-tianjin-china-a-cross-sectional-study
#8
Xiaoqian Liu, Yuting Guo, Dandan Li, Zhuang Cui, Yuanyuan Liu, Changping Li, Jun Ma
Little is known about hospital readmission for patients with diabetes in China. We aimed to assess the temporal pattern, risk factors, and variations of all-cause readmission among hospitalized patients with diabetes in Tianjin, China, from 2008 to 2013.The Tianjin Basic Medical Insurance Register System database was used to identify discharged patients with diabetes from 2008 to 2013. The influential factors and trends of rehospitalization were analyzed for 30-, 60- and 90-day predicted readmission rates. The Blinder-Oaxaca decomposition was used to explain the readmission variations between 2008 and 2013...
October 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29049116/basic-translational-development-of-forthcoming-opioid-and-nonopioid-targeted-pain-therapeutics
#9
Nebojsa Nick Knezevic, Ajay Yekkirala, Tony L Yaksh
Opioids represent an efficacious therapeutic modality for some, but not all pain states. Singular reliance on opioid therapy for pain management has limitations, and abuse potential has deleterious consequences for patient and society. Our understanding of pain biology has yielded insights and opportunities for alternatives to conventional opioid agonists. The aim is to have efficacious therapies, with acceptable side effect profiles and minimal abuse potential, which is to say an absence of reinforcing activity in the absence of a pain state...
November 2017: Anesthesia and Analgesia
https://www.readbyqxmd.com/read/29049078/hearts-and-minds-real-life-cardiotoxicity-with-clozapine-in-psychosis
#10
George Joy, Eromona Whiskey, Mark Bolstridge, Alejandro Porras-Segovia, Theresa A McDonagh, Carla M Plymen, Sukhi S Shergill
BACKGROUND: Schizophrenia has a 1% prevalence in the population; 30% of these patients are treatment refractory. Clozapine is the only drug licensed to treat treatment refractory psychosis, but concerns about potential adverse effects result in only a proportion of eligible patients being treated. Although a well-documented neutropenia risk is mitigated by routine blood testing, cardiac toxicity is a commonly cited reason to discontinue clozapine treatment. However, there is little data on the real-life cardiac outcomes in those receiving clozapine treatment...
October 19, 2017: Journal of Clinical Psychopharmacology
https://www.readbyqxmd.com/read/29049057/the-postpartum-maternal-and-newborn-microbiomes
#11
Abby D Mutic, Sheila Jordan, Sara M Edwards, Erin P Ferranti, Taylor A Thul, Irene Yang
Biological and environmental changes to maternal and newborn microbiomes in the postnatal period can affect health outcomes for the mother-baby dyad. Postpartum sleep deprivation and unmet dietary needs can alter commensal bacteria within the body and disrupt gut-brain communication. Perineal injury and breast infections also change microbial community composition, potentiating an environment favoring pathogen growth. The gut microbiome refers to the collection of microorganisms working in harmony. Disruptions within the gut microbiome and gut-brain communication may lead to postpartum depression, a potentially devastating sequela...
November 2017: MCN. the American Journal of Maternal Child Nursing
https://www.readbyqxmd.com/read/29049041/the-impact-of-lifestyle-intervention-on-atrial-fibrillation
#12
Kathryn L Hong, Benedict M Glover
PURPOSE OF REVIEW: Atrial fibrillation is the most common sustained cardiac arrhythmia, attributable to several factors that may be amenable through lifestyle modification. There is emerging evidence to suggest that the successful management of several cardiovascular risk factors [obesity, hypertension (HTN), diabetes mellitus, and obstructive sleep apnea (OSA)] can lead to fewer complications and atrial fibrillation prevention. However, the long-term sustainability and reproducibility of these effects have yet to be explored in larger studies...
October 18, 2017: Current Opinion in Cardiology
https://www.readbyqxmd.com/read/29048739/pharmacotherapy-for-social-anxiety-disorder-sand
#13
REVIEW
Taryn Williams, Coenraad J Hattingh, Catherine M Kariuki, Sean A Tromp, Anton J van Balkom, Jonathan C Ipser, Dan J Stein
BACKGROUND: Recognition is growing that social anxiety disorder (SAnD) is a chronic and disabling disorder, and data from early trials demonstrate that medication may be effective in its treatment. This systematic review is an update of an earlier review of pharmacotherapy of SAnD. OBJECTIVES: To assess the effects of pharmacotherapy for social anxiety disorder in adults and identify which factors (methodological or clinical) predict response to treatment. SEARCH METHODS: We searched the Cochrane Common Mental Disorders Controlled Trials Register (CCMDCTR-Studies and CCMDCTR-References) to 17 August 2015...
October 19, 2017: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/29048572/ventriculoscopic-surgery-for-cystic-retrochiasmatic-craniopharyngiomas-indications-surgical-technique-and-short-term-patient-outcomes
#14
Todd C Hollon, Luis E Savastano, David Altshuler, Ariel L Barkan, Stephen E Sullivan
BACKGROUND: Attempted gross-total resection for the management of cystic retrochiasmatic craniopharyngiomas can cause severe hypothalamic dysfunction and decrease overall survival. Ventriculoscopic surgery is a minimally invasive alternative; however, potential indications and technique have not been well defined. OBJECTIVE: To present our indications and technique for the ventriculoscopic treatment of cystic retrochiasmatic craniopharyngiomas. METHODS: We evaluated all patients with retrochiasmatic craniopharyngiomas for ventriculoscopic surgery...
October 18, 2017: Operative Neurosurgery (Hagerstown, Md.)
https://www.readbyqxmd.com/read/29048556/deep-brain-stimulation-related-infections-analysis-of-rates-timing-and-seasonality
#15
Fran A Hardaway, Ahmed M Raslan, Kim J Burchiel
BACKGROUND: Infection is one of the most common complications of deep brain stimulation (DBS). Long-term infection rates beyond the immediate postoperative period are rarely evaluated. OBJECTIVE: To study short- and long-term DBS-related infection rates; to evaluate any potential seasonality associated with DBS-related infections. METHODS: We retrospectively reviewed all DBS surgeries performed in a 5-yr period at 1 hospital by a single surgeon...
October 18, 2017: Neurosurgery
https://www.readbyqxmd.com/read/29048465/%C3%AE-app-processing-drives-gradual-tau-pathology-in-an-age-dependent-amyloid-rat-model-of-alzheimer-s-disease
#16
Mickael Audrain, Benoit Souchet, Sandro Alves, Romain Fol, Arthur Viode, Alexis Haddjeri, Satoru Tada, Nicola S Orefice, Charlène Joséphine, Alexis-Pierre Bemelmans, Thierry Delzescaux, Nicole Déglon, Philippe Hantraye, Yvette Akwa, François Becher, Jean-Marie Billard, Brigitte Potier, Patrick Dutar, Nathalie Cartier, Jérôme Braudeau
The treatment of Alzheimer's disease (AD) remains challenging and requires a better in depth understanding of AD progression. Particularly, the link between amyloid protein precursor (APP) processing and Tau pathology development remains poorly understood. Growing evidences suggest that APP processing and amyloid-β (Aβ) release are upstream of Tau pathology but the lack of animal models mimicking the slow progression of human AD raised questions around this mechanism. Here, we described that an AD-like βAPP processing in adults wild-type rats, yielding to human APP, βCTF and Aβ levels similar to those observed in AD patients, is sufficient to trigger gradual Tauopathy...
October 18, 2017: Cerebral Cortex
https://www.readbyqxmd.com/read/29047327/integrative-testis-transcriptome-analysis-reveals-differentially-expressed-mirnas-and-their-mrna-targets-during-early-puberty-in-atlantic-salmon
#17
K O Skaftnesmo, R B Edvardsen, T Furmanek, D Crespo, E Andersson, L Kleppe, G L Taranger, J Bogerd, R W Schulz, A Wargelius
BACKGROUND: Our understanding of the molecular mechanisms implementing pubertal maturation of the testis in vertebrates is incomplete. This topic is relevant in Atlantic salmon aquaculture, since precocious male puberty negatively impacts animal welfare and growth. We hypothesize that certain miRNAs modulate mRNAs relevant for the initiation of puberty. To explore which miRNAs regulate mRNAs during initiation of puberty in salmon, we performed an integrated transcriptome analysis (miRNA and mRNA-seq) of salmon testis at three stages of development: an immature, long-term quiescent stage, a prepubertal stage just before, and a pubertal stage just after the onset of single cell proliferation activity in the testis...
October 18, 2017: BMC Genomics
https://www.readbyqxmd.com/read/29047102/reactive-oxygen-species-in-copd-related-vascular-remodeling
#18
Li Zuo, Chia-Chen Chuang, Alexander D Clark, Davis E Garrison, Jamie L Kuhlman, David C Sypert
The pathogenesis of chronic obstructive pulmonary disease (COPD) is a multifaceted process involving the alteration of pulmonary vasculature. Such vascular remodeling can be associated with inflammation, shear stress, and hypoxia-conditions commonly seen in patients with lung diseases. Particularly, the overproduction of reactive oxygen species (ROS) in the diseased lungs contributes greatly to pulmonary vascular remodeling. ROS play an important role in vascular homeostasis, yet excessive ROS can alter pulmonary vasculature and impair lung function, as implicated in COPD at all stages...
2017: Advances in Experimental Medicine and Biology
https://www.readbyqxmd.com/read/29046729/long-term-feeding-of-high-fat-plus-high-fructose-diet-induces-isolated-impaired-glucose-tolerance-and-skeletal-muscle-insulin-resistance-in-miniature-pigs
#19
Meng-Chieh Hsu, Mu-En Wang, Yi-Fan Jiang, Hung-Chang Liu, Yi-Chen Chen, Chih-Hsien Chiu
BACKGROUND: During the prediabetic development, the changes in β-cell function and tissue-specific insulin resistance have been described. However, there are conflicting views in insulin secretory capacity between early clinical observation and recent proposed mathematical model. On the basis of digestive and metabolic similarities with humans, swine have great potential as an animal model to investigate the progressive mechanisms of prediabetes. The aim of this study was to investigate the insulin secretory response and tissue-specific insulin resistance in a dietary-induced prediabetic porcine model...
2017: Diabetology & Metabolic Syndrome
https://www.readbyqxmd.com/read/29046697/preclinical-safety-assessment-of-angelica-acutiloba-using-a-13-week-repeated-dose-oral-toxicity-study-in-rats
#20
Jun-Won Yun, Euna Kwon, Seung-Hyun Kim, Ji-Ran You, Yun-Soon Kim, In Ae Park, Hyeon Hoe Kim, Jeong-Hwan Che, Byeong-Cheol Kang
Angelica acutiloba (AA), a Japanese species of Danggui, has been used worldwide as a traditional herbal medicine with several bioactivities including anti-diabetic, anti-allergic, anti-inflammatory, anti-tumor, and anti-obesity. However, there is lack of toxicological data available to evaluate potential long-term toxicity and the no-observed-adverse-effect level (NOAEL) of AA extract in accordance with the test guidelines published by the Organization for Economic Cooperation and Development. In the 14-day repeat-dose toxicity study, no adverse effects on mortality, body weight change, clinical signs, and organ weights was found following repeat oral administration to rats for 14 days (125, 250, 500, 1000, and 2000 mg/kg body weight), leading that 2000 mg/kg is the highest recommended dose of AA extract for the 13-week repeat-dose oral toxicity study...
September 2017: Laboratory Animal Research
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