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https://www.readbyqxmd.com/read/29783162/a-peripheral-immune-response-to-remembering-trauma-contributes-to-the-maintenance-of-fear-memory-in-mice
#1
Matthew B Young, Leonard L Howell, Lauren Hopkins, Cassandra Moshfegh, Zhe Yu, Lauren Clubb, Jessica Seidenberg, Jeanie Park, Adam P Swiercz, Paul J Marvar
Alterations in peripheral immune markers are observed in individuals with post-traumatic stress disorder (PTSD). PTSD is characterized in part by impaired extinction of fear memory for a traumatic experience. We hypothesized that fear memory extinction is regulated by immune signaling stimulated when fear memory is retrieved. The relationship between fear memory and the peripheral immune response was tested using auditory Pavlovian fear conditioning in mice. Memory for the association was quantified by the amount of conditioned freezing exhibited in response to the conditioned stimulus (CS), extinction and time-dependent changes in circulating inflammatory cytokines...
May 17, 2018: Psychoneuroendocrinology
https://www.readbyqxmd.com/read/29777319/what-does-sex-have-to-do-with-it-the-role-of-sex-as-a-biological-variable-in-the-development-of-posttraumatic-stress-disorder
#2
REVIEW
Sara L Kornfield, Liisa Hantsoo, C Neill Epperson
PURPOSE OF REVIEW: This review highlights the neurobiological aspects of sex differences in posttraumatic stress disorder (PTSD), specifically focusing on the physiological responses to trauma and presents evidence supporting hormone and neurosteroid/peptide differences from both preclinical and clinical research. RECENT FINDINGS: While others have suggested that trauma type or acute emotional reaction are responsible for women's disproportionate risk to PTSD, neither of these explanations fully accounts for the sex differences in PTSD...
May 18, 2018: Current Psychiatry Reports
https://www.readbyqxmd.com/read/29775962/preterm-birth-and-oxidative-stress-effects-of-acute-physical-exercise-and-hypoxia-physiological-responses
#3
Agnès Martin, Camille Faes, Tadej Debevec, Chantal Rytz, Grégoire Millet, Vincent Pialoux
Preterm birth is a global health issue that can induce lifelong medical sequela. Presently, at least one in ten newborns are born prematurely. At birth, preterm newborns exhibit higher levels of oxidative stress (OS) due to the inability to face the oxygen rich environment in which they are born into. Moreover, their immature respiratory, digestive, immune and antioxidant defense systems, as well as the potential numerous medical interventions following a preterm birth, such as oxygen resuscitation, nutrition, phototherapy and blood transfusion further contribute to high levels of OS...
May 1, 2018: Redox Biology
https://www.readbyqxmd.com/read/29775874/emotion-regulation-as-a-predictor-of-the-endocrine-autonomic-affective-and-symptomatic-stress-response-and-recovery
#4
Katarina Krkovic, Annika Clamor, Tania M Lincoln
Stress is associated with the development of mental disorders such as depression and psychosis. The ability to regulate emotions is likely to influence how individuals respond to and recover from acute stress, and may thus be relevant to symptom development. To test this, we investigated whether self-reported emotion regulation predicts the endocrine, autonomic, affective, and symptomatic response to and recovery from a stressor. Social-evaluative stress was induced by the Trier Social Stress Test (TSST) in N = 67 healthy individuals (53...
April 30, 2018: Psychoneuroendocrinology
https://www.readbyqxmd.com/read/29773309/posttraumatic-stress-disorder-in-patients-who-rule-out-versus-rule-in-for-acute-coronary-syndrome
#5
Ian M Kronish, Donald Edmondson, Nathalie Moise, Bernard P Chang, Ying Wei, David Lopez Veneros, William Whang
OBJECTIVE: Many patients who present to the emergency department (ED) with acute coronary syndromes (ACS) develop posttraumatic stress disorder (PTSD) due to the experience. Less is known about risk for PTSD in patients who rule out for ACS. Our objective was to compare the risk of developing PTSD among patients who rule out versus rule in for ACS. METHODS: We enrolled a consecutive sample of 1000 patients presenting to an emergency department (ED) with symptoms of a probable ACS...
May 14, 2018: General Hospital Psychiatry
https://www.readbyqxmd.com/read/29772354/acute-and-subacute-toxicity-and-chemical-constituents-of-the-hydroethanolic-extract-of-verbena-litoralis-kunth
#6
Rachel de Lima, Camille Gaube Guex, Andreia Regina Haas da Silva, Cibele Lima Lhamas, Karen Luise Dos Santos Moreira, Rosana Casoti, Rafaela Castro Dornelles, Maria Izabel Ugalde Marques da Rocha, Marcelo Leite da Veiga, Liliane de Freitas Bauermann, Melânia Palermo Manfron
ETHNOPHARMACOLOGICAL RELEVANCE: Verbena litoralis Kunth is a native species of South America, popularly known as gervãozinho-do-campo ou erva-de-pai-caetano. It is used in gastrointestinal disorders, as detoxifying the organism, antifebrile properties and amidaglitis. AIM OF THE STUDY: To identify the chemical constituents of the hydroethanolic extract obtained from the aerial parts of V. litoralis and to evaluate the acute and sub-acute toxicity in male and female rats...
May 14, 2018: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/29767649/experimental-psychological-stress-on-quantitative-sensory-testing-response-in-patients-with-temporomandibular-disorders
#7
Dyna Mara Araújo Oliveira Ferreira, Yuri Martins Costa, Henrique Müller de Quevedo, Leonardo Rigoldi Bonjardim, Paulo César Rodrigues Conti
AIMS: To assess the modulatory effects of experimental psychological stress on the somatosensory evaluation of myofascial temporomandibular disorder (TMD) patients. METHODS: A total of 20 women with myofascial TMD and 20 age-matched healthy women were assessed by means of a standardized battery of quantitative sensory testing. Cold detection threshold (CDT), warm detection threshold (WDT), cold pain threshold (CPT), heat pain threshold (HPT), mechanical pain threshold (MPT), wind-up ratio (WUR), and pressure pain threshold (PPT) were performed on the facial skin overlying the masseter muscle...
May 15, 2018: Journal of Oral & Facial Pain and Headache
https://www.readbyqxmd.com/read/29763682/melatonin-attenuates-arsenic-induced-nephropathy-via-the-regulation-of-oxidative-stress-and-inflammatory-signaling-cascades-in-mice
#8
Sayanta Dutta, Sukanya Saha, Sushweta Mahalanobish, Pritam Sadhukhan, Parames C Sil
Arsenic is a potent inducer of several acute and chronic nephrotoxic disorders. It promotes deleterious phenomenon like oxidative stress, inflammation, cell death and altered glucose uptake leading to distorted kidney homeostasis that end up in chronic kidney disease. This study investigated the possible protective role of melatonin; a natural antioxidant produced by the pineal gland, against arsenic induced nephrotoxicity. Melatonin successfully ameliorated arsenic induced renal toxicity both in in vitro and in vivo models...
May 12, 2018: Food and Chemical Toxicology
https://www.readbyqxmd.com/read/29755579/exploring-ptsd-in-emergency-operators-of-a-major-university-hospital-in-italy-a-preliminary-report-on-the-role-of-gender-age-and-education
#9
Claudia Carmassi, Camilla Gesi, Martina Corsi, Ivan M Cremone, Carlo A Bertelloni, Enrico Massimetti, Maria Cristina Olivieri, Ciro Conversano, Massimo Santini, Liliana Dell'Osso
Background: Emergency services personnel face frequent exposure to potentially traumatic events, with the potential for chronic symptomatic distress. The DSM-5 recently recognized a particular risk for post-traumatic stress disorder (PTSD) among first responders (criterion A4) but data are still scarce on prevalence rates and correlates. Objective: The aim of the present study was to explore the possible role of age, gender, and education training in a sample of emergency personnel diagnosed with DSM-5 PTSD...
2018: Annals of General Psychiatry
https://www.readbyqxmd.com/read/29754117/sleep-problems-six-months-after-continuous-earthquake-activity-in-a-greek-island
#10
H Lazaratou, Th Paparrigopoulos, Chr Anomitri, N Alexandropoulou, G Galanos, Ch Papageorgiou
Natural disasters, such as earthquakes, are traumatic events causing both acute and enduring stress to affected individuals. Psychosocial consequences include posttraumatic stress disorder (PTSD), reactions of anxiety and depression and sleep problems. The island of Cephalonia in Ionian Sea is characterized by its high seismic activity. More specifically, this activity has been considered to be the highest of the Balkan Peninsula and Europe in general. In January and February of 2014 a long sequence of earthquakes, which included two main shocks of 6...
January 2018: Psychiatrikē, Psychiatriki
https://www.readbyqxmd.com/read/29746845/detection-of-stress-and-the-effects-of-central-nervous-system-depressants-by-gastrointestinal-smooth-muscle-electromyography-in-wakeful-rats
#11
K F Szűcs, G Grosz, M Süle, A Sztojkov-Ivanov, E Ducza, A Márki, A Kothencz, L Balogh, R Gáspár
AIMS: The altered gut-brain interaction can be in the background of functional gastrointestinal (GI) disorders. In the GI tract, the slow-wave myoelectric signals can be detected by electromyography (EMG). The aims of our study were to follow up the stress induced alteration in the GI tract by smooth muscle EMG in wakeful rats. MAIN METHODS: The GI tract myoelectric activity of male rats was measured by an electrode pair under the abdominal skin, the responses were detected and analyzed by a software using fast Fourier transformation...
May 7, 2018: Life Sciences
https://www.readbyqxmd.com/read/29745454/effects-of-short-term-clomipramine-on-anxiety-like-behavior-cellular-metabolism-and-oxidative-stress-in-primary-fibroblast-cells-of-male-and-female-rats
#12
Ana G Jimenez, Joshua D Winward, Dana M Smith, Christina M Ragan
Anxiety is the most prevalent mental disorder among adults in the United States and females tend to have significantly higher rates of anxiety compared with men. Common treatments for anxiety include usage of selective serotonin reuptake inhibitors (SSRIs) and tricyclic antidepressants, however, sex differences in the efficacy of these drugs exist. In this study, we were interested in determining if acutely manipulating serotonin mechanisms at the whole-animal level affects cellular metabolism and oxidative stress in primary fibroblast cells from clomipramine-treated Sprague-Dawley rats...
May 2018: Physiological Reports
https://www.readbyqxmd.com/read/29743387/suhexiang-essential-oil-inhalation-produces-antidepressant-and-anxiolytic-like-effects-in-adult-mice
#13
Min Liang, Yuru Du, Wenjing Li, Xi Yin, Ni Yang, Anran Qie, Tyler W LeBaron, Jiayu Zhang, Haiying Chen, Haishui Shi
SuHeXiang (SHX) has been used to treat a wide range of diseases, including those related to the central nervous system. However, the effects of SHX on mood disorders are still elusive. This study aimed to investigate the effects of SHX essential oil on stress-induced depression of mice. In an acute stress-induced depression model, mice inhaled vehicle (1% Tween80) for 10 min or 10% SHX for 10 or 30 min once daily for 12 continuous days. In the chronic mild stress (CMS)-induced depression model, mice were exposed to a 28-d CMS treatment...
May 9, 2018: Biological & Pharmaceutical Bulletin
https://www.readbyqxmd.com/read/29742447/the-discovery-of-nitro-fatty-acids-as-products-of-metabolic-and-inflammatory-reactions-and-mediators-of-adaptive-cell-signaling
#14
REVIEW
Bruce A Freeman, Valerie B O'Donnell, Francisco J Schopfer
Foundational advances in eicosanoid signaling, the free radical biology of oxygen and nitric oxide and mass spectrometry all converged to enable the discovery of nitrated unsaturated fatty acids. Due to the unique biochemical characteristics of fatty acid nitroalkenes, these species undergo rapid and reversible Michael addition of biological nucleophiles such as cysteine, leading to the post-translational modification of low molecular weight and protein thiols. This capability has led to the present understanding that nitro-fatty acid reaction with the alkylation-sensitive cysteine proteome leads to physiologically-beneficial alterations in transcriptional regulatory protein function, gene expression and in vivo rodent model responses to metabolic and inflammatory stress...
May 6, 2018: Nitric Oxide: Biology and Chemistry
https://www.readbyqxmd.com/read/29737252/does-ceruloplasmin-defend-against-neurodegenerative-diseases
#15
Bo Wang, Xiao-Ping Wang
Ceruloplasmin (CP) is the major copper transport protein in plasma, mainly produced by the liver. Glycosylphosphatidylinositol-linked CP (GPI-CP) is the predominant form expressed in astrocytes of the brain. A growing body of evidence has demonstrated that CP is an essential protein in body with multiple functions such as regulating the homeostasis of copper and iron ions, ferroxidase activity, oxidizing organic amines, and preventing the formation of free radicals. In addition, as an acute-phase protein, CP is induced during inflammation and infection...
May 7, 2018: Current Neuropharmacology
https://www.readbyqxmd.com/read/29737034/distress-intolerance-moderation-of-motivated-attention-to-cannabis-and-negative-stimuli-after-induced-stress-among-cannabis-users-an-erp-study
#16
Richard J Macatee, Sarah A Okey, Brian J Albanese, Norman B Schmidt, Jesse R Cougle
Prevalence of cannabis use is increasing, but many regular users do not develop cannabis use disorder (CUD); thus, CUD risk identification among current users is vital for targeted intervention development. Existing data suggest that high distress intolerance (DI), an individual difference reflective of the ability to tolerate negative affect, may be linked to CUD, but no studies have tested possible neurophysiological mechanisms. Increased motivated attentional processing of cannabis and negative emotional stimuli as indexed by neurophysiology [i...
May 7, 2018: Addiction Biology
https://www.readbyqxmd.com/read/29736064/psychiatric-comorbidities-in-acute-coronary-syndromes-six-month-follow-up-study
#17
D Ramya Shruthi, S Sunil Kumar, Nagaraj Desai, Rajesh Raman, T S Sathyanarayana Rao
Introduction: Acute coronary syndrome (ACS) caused by coronary atherosclerosis include ST-segment elevation myocardial infarction (STEMI), non-STEMI, and unstable angina. The relation between psychiatric disorders and coronary artery disease is a complex one which includes the effect of the psychosocial factors on heart and vice versa. Point prevalence studies have been reported, but there is paucity of follow-up studies from India. Materials and Methods: The study is a follow-up evaluation at discharge of 248 consecutive patients presented with ACS at JSS Hospital, Mysuru, Karnataka, over a period of 6 months to assess the psychiatric comorbidities...
January 2018: Indian Journal of Psychiatry
https://www.readbyqxmd.com/read/29735991/increased-piezo1-channel-activity-in-interstitial-cajal-like-cells-induces-bladder-hyperactivity-by-functionally-interacting-with-ncx1-in-rats-with-cyclophosphamide-induced-cystitis
#18
Qian Liu, Bishao Sun, Jiang Zhao, Qingqing Wang, Fan An, Xiaoyan Hu, Zhenxing Yang, Jie Xu, Mingjia Tan, Longkun Li
The Piezo1 channel is a mechanotransduction mediator, and Piezo1 abnormalities have been linked to several clinical disorders. However, the role of the Piezo1 channel in cystitis-associated bladder dysfunction has not been documented. The current study aimed to discover the functional role of this channel in regulating bladder activity during cyclophosphamide (CYP)-induced cystitis. One hundred four female rats were randomly assigned to the control, CYP-4h, CYP-48h and CYP-8d groups. CYP successfully induced acute or chronic cystitis in these rats...
May 7, 2018: Experimental & Molecular Medicine
https://www.readbyqxmd.com/read/29734227/fear-processing-psychophysiology-and-ptsd
#19
Seth Davin Norrholm, Tanja Jovanovic
The processing and regulation of fear is one of the key components of posttraumatic stress disorder (PTSD). Fear can involve both acute and potential threats that can manifest in different behaviors and result from activity within different neural nodes and networks. Fear circuits have been studied extensively in animal models for several decades and in human neuroimaging research for almost 20 years. Therefore, the centrality of fear processing to PTSD lends the disorder to be more tractable to investigation at the level of brain and behavior, and provides several observable phenotypes that can be linked to PTSD symptoms...
May 2018: Harvard Review of Psychiatry
https://www.readbyqxmd.com/read/29731716/protective-effect-of-casperome-%C3%A2-an-orally-bioavailable-frankincense-extract-on-lipopolysaccharide-induced-systemic-inflammation-in-mice
#20
Konstantin Loeser, Semjon Seemann, Stefanie König, Isabell Lenhardt, Mona Abdel-Tawab, Andreas Koeberle, Oliver Werz, Amelie Lupp
Introduction: Despite recent advances in critical care, sepsis remains a crucial cause of morbidity and mortality in intensive care units. Therefore, the identification of new therapeutic strategies is of great importance. Since ancient times, frankincense is used in traditional medicine for the treatment of chronic inflammatory disorders such as rheumatoid arthritis. Thus, the present study intends to evaluate if Casperome® (Casp), an orally bioavailable soy lecithin-based formulation of standardized frankincense extract, is able to ameliorate systemic effects and organ damages induced by severe systemic inflammation using a murine model of sepsis, i...
2018: Frontiers in Pharmacology
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