Maria Ironside, Jessica M Duda, Amelia D Moser, Laura M Holsen, Chun S Zuo, Fei Du, Sarah Perlo, Christine E Richards, Xi Chen, Lisa D Nickerson, Kaylee E Null, Shiba M Esfand, Madeline M Alexander, David J Crowley, Meghan Lauze, Madhusmita Misra, Jill M Goldstein, Diego A Pizzagalli
OBJECTIVE: Preclinical work suggests that excess glucocorticoids and reduced cortical γ-aminobutyric acid (GABA) may affect sex-dependent differences in brain regions implicated in stress regulation and depressive phenotypes. The authors sought to address a critical gap in knowledge, namely, how stress circuitry is functionally affected by glucocorticoids and GABA in current or remitted major depressive disorder (MDD). METHODS: Multimodal imaging data were collected from 130 young adults (ages 18-25), of whom 44 had current MDD, 42 had remitted MDD, and 44 were healthy comparison subjects...
April 30, 2024: American Journal of Psychiatry