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https://www.readbyqxmd.com/read/28741031/inhibition-of-serotonin-transporters-disrupts-the-enhancement-of-fear-memory-extinction-by-3-4-methylenedioxymethamphetamine-mdma
#1
Matthew B Young, Seth D Norrholm, Lara M Khoury, Tanja Jovanovic, Sheila A M Rauch, Collin M Reiff, Boadie W Dunlop, Barbara O Rothbaum, Leonard L Howell
RATIONALE: 3,4-Methylenedioxymethamphetamine (MDMA) persistently improves symptoms of post-traumatic stress disorder (PTSD) when combined with psychotherapy. Studies in rodents suggest that these effects can be attributed to enhancement of fear memory extinction. Therefore, MDMA may improve the effects of exposure-based therapy for PTSD, particularly in treatment-resistant patients. However, given MDMA's broad pharmacological profile, further investigation is warranted before moving to a complex clinical population...
July 24, 2017: Psychopharmacology
https://www.readbyqxmd.com/read/28735366/further-validation-of-the-affective-bias-test-for-predicting-antidepressant-and-pro-depressant-risk-effects-of-pharmacological-and-social-manipulations-in-male-and-female-rats
#2
Justyna K Hinchcliffe, Sarah A Stuart, Michael Mendl, Emma S J Robinson
RATIONALE: Affective biases are hypothesised to contribute to the cause and treatment of mood disorders. We have previously found that affective biases, associated with learning and memory, are observed following acute treatments with a range of antidepressant and pro-depressant manipulations. OBJECTIVE: This study aimed to test if similar biases are observed in male and female Sprague Dawley (SD) rats. We also test whether the stress hormone, corticosterone, induces a negative bias in the affective bias test (ABT) consistent with its putative role in the development of depression...
July 22, 2017: Psychopharmacology
https://www.readbyqxmd.com/read/28715786/background-lead-and-mercury-exposures-psychological-and-behavioral-problems-in-children
#3
Brooks B Gump, Matthew J Dykas, James A MacKenzie, Amy K Dumas, Bryce Hruska, Craig K Ewart, Patrick J Parsons, Christopher D Palmer, Kestutis Bendinskas
BACKGROUND: The potential harm from exposure to nonessential metals, particularly mercury (Hg) and lead (Pb), has been the focus of research for years. Initial interest focused on relatively high exposures; however, recent evidence suggests that even background exposures might have adverse consequences for child development. Identifying the extent of these consequences is now a priority. METHODS: We assessed blood Pb and Hg levels in a biracial sample of 9-11 year-old children (N = 203)...
July 14, 2017: Environmental Research
https://www.readbyqxmd.com/read/28709061/exploring-dsm-5-criterion-a-in-acute-stress-disorder-symptoms-following-natural-disaster
#4
Osnat Lavenda, Ephraim S Grossman, Menachem Ben-Ezra, Yaakov Hoffman
The present study examines the DSM-5 Acute Stress Disorder (ASD) diagnostic criteria of exposure, in the context of a natural disaster. The study is based on the reports of 1001 Filipinos following the aftermath of super typhoon Haiyan in 2013. Participants reported exposure to injury, psychological distress and ASD symptoms. Findings indicated the association of criterion A with the prevalence of meeting all other ASD diagnostic criteria and high psychological distress. The diagnostic properties of Criterion A are discussed...
July 10, 2017: Psychiatry Research
https://www.readbyqxmd.com/read/28708283/acute-stress-symptoms-in-seriously-injured-patients-precipitating-versus-cumulative-trauma-and-the-contribution-of-peritraumatic-distress
#5
John Briere, Colin P Dias, Randye J Semple, Catherine Scott, Noémie Bigras, Natacha Godbout
The relationship between type of trauma exposure, cumulative trauma, peritraumatic distress, and subsequent acute stress disorder (ASD) symptoms was examined prospectively in 96 individuals presenting with acute medical injuries to a Level 1 emergency/trauma department. Common precipitating traumas included motor vehicle-related events, stabbings, shootings, and physical assaults. At 2 to 3 weeks follow-up, 22.9% of participants had developed ASD. Univariate analysis revealed no relationship between type of precipitating trauma and ASD symptoms, whereas robust path analysis indicated direct effects of gender, lifetime cumulative trauma exposure, and peritraumatic distress...
July 14, 2017: Journal of Traumatic Stress
https://www.readbyqxmd.com/read/28699766/assessing-acute-psychological-distress-in-the-immediate-aftermath-of-stroke
#6
Vanessa Juth, Michelle K Chan, Steven C Cramer, E Alison Holman
BACKGROUND AND PURPOSE: High acute stress may presage the development of subsequent cardiovascular ailments. Understanding how best to assess acute stress may inform early interventions seeking to prevent long-term morbidity/mortality following stroke. A mixed methods approach examined early post-stroke acute stress symptoms using the post-traumatic stress disorder checklist-5 (PCL-5) and the acute stress disorder scale (ASDS). METHODS: A focus group of stroke survivors and/or their caregivers ( N=8) evaluated PCL-5/ASDS feasibility, and 20 patients hospitalized for acute stroke were interviewed 2-10 days post-stroke onset, using either the PCL-5 or the ASDS...
July 1, 2017: European Journal of Cardiovascular Nursing
https://www.readbyqxmd.com/read/28691844/the-impact-of-acute-stress-on-the-neural-processing-of-food-cues-in-bulimia-nervosa-replication-in-two-samples
#7
Brittany Collins, Lauren Breithaupt, Jennifer E McDowell, L Stephen Miller, James Thompson, Sarah Fischer
The impact of acute stress on the neural processing of food cues in bulimia nervosa (BN) is unknown, despite theory that acute stress decreases cognitive control over food and hence increases vulnerability to environmental triggers for binge eating. Thus, the goals of this manuscript were to explore the impact of acute stress on the neural processing of food cues in BN. In Study 1, 10 women with Diagnostic and Statistical Manual of Mental Disorders (5th ed.; DSM-5; American Psychiatric Association, 2013) BN and 10 healthy controls participated in an fMRI paradigm examining the neural correlates of visual food cue processing pre and post an acute stress induction...
July 2017: Journal of Abnormal Psychology
https://www.readbyqxmd.com/read/28688269/nature-based-solution-for-improving-mental-health-and-well-being-in-urban-areas
#8
Maja Vujcic, Jelena Tomicevic-Dubljevic, Mihailo Grbic, Dusica Lecic-Tosevski, Olivera Vukovic, Oliver Toskovic
The general disproportion of urban development and the socio-economical crisis in Serbia, followed by a number of acute and chronic stressors, as well as years of accumulated trauma, prevented the parallel physical, mental and social adaptation of society as a whole. These trends certainly affected the quality of mental health and well-being, particularly on the vulnerable urban population, increasing the absolute number of people with depression, stress and psychosomatic disorders. This study was pioneering in Serbia and was conducted in collaboration with the Faculty of Forestry, the Institute of Mental Health and the Botanical Garden in Belgrade, in order to understand how spending time and performing horticulture therapy in specially designed urban green environments can improve mental health...
July 4, 2017: Environmental Research
https://www.readbyqxmd.com/read/28685436/cortical-and-autonomic-stress-responses-in-adults-with-high-versus-low-levels-of-trait-anxiety-a-pilot-study
#9
A Brugnera, C Zarbo, R Adorni, A Compare, K Sakatani
Stress responses are mediated by complex patterns of cortical and autonomic activity. Earlier studies showed increased recruitment of the right prefrontal cortex (PFC) and parasympathetic withdrawal during a stress task; however, it remains unclear whether these responses change in relation to different levels of psychopathological symptoms, such as trait anxiety. The present study examines the effect of a mathematical task (with a control condition and a stressful/experimental condition) on the PFC and autonomic activity, using a two-channel near infrared spectroscopy (NIRS) and an ECG monitoring system...
2017: Advances in Experimental Medicine and Biology
https://www.readbyqxmd.com/read/28682981/risk-factors-of-delayed-onset-posttraumatic-stress-disorder-in-chronically-critically-ill-patients
#10
Gloria-Beatrice Wintermann, Jenny Rosendahl, Kerstin Weidner, Bernhard Strauß, Katja Petrowski
The main aim of this study was to investigate factors associated with a delayed-onset posttraumatic stress disorder (PTSD) after the intensive care unit (ICU) treatment of patients with a chronic critical illness (CCI). Patients (n = 97) with critical illness polyneuropathy or critical illness myopathy were interviewed via the Structured Clinical Interview for Diagnostic and Statistical Manual of Mental Disorders, 4th Edition. The diagnosis of the acute stress disorder was assessed within 1 month (t1), the diagnosis of PTSD at 3 (t2) and 6 (t3) months after transfer from the acute care ICU to the post-acute ICU...
July 5, 2017: Journal of Nervous and Mental Disease
https://www.readbyqxmd.com/read/28682883/nivolumab-induced-myasthenia-gravis-in-a-patient-with-squamous-cell-lung-carcinoma-case-report
#11
Yu-Hsiu Chen, Feng-Cheng Liu, Chang-Hung Hsu, Chih-Feng Chian
RATIONALE: Nivolumab (Nivo) is an immune checkpoint inhibitor that has been used to treat advanced melanoma, nonsmall cell lung carcinoma, and renal cell carcinoma since 2015. Nivo is associated with several side effects, including hepatitis, pneumonitis, acute renal failure, endocrine disorder, and other immune-related adverse events. Here, we describe the case of a 65-year-old man with squamous cell lung carcinoma who developed myasthenia gravis (MG) after a third Nivo infusion. PATIENT CONCERNS: A 65-year-old man with advanced squamous cell lung carcinoma developed ptosis, diplopia, drop head, and general weakness 5 days after a third Nivo infusion...
July 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28680391/the-role-of-the-multifunctional-bag3-protein-in-cellular-protein-quality-control-and-in-disease
#12
REVIEW
Elisabeth Stürner, Christian Behl
In neurons, but also in all other cells the complex proteostasis network is monitored and tightly regulated by the cellular protein quality control (PQC) system. Beyond folding of newly synthesized polypeptides and their refolding upon misfolding the PQC also manages the disposal of aberrant proteins either by the ubiquitin-proteasome machinery or by the autophagic-lysosomal system. Aggregated proteins are primarily degraded by a process termed selective macroautophagy (or aggrephagy). One such recently discovered selective macroautophagy pathway is mediated by the multifunctional HSP70 co-chaperone BAG3 (BCL-2-associated athanogene 3)...
2017: Frontiers in Molecular Neuroscience
https://www.readbyqxmd.com/read/28675115/nicotine-disrupts-safety-learning-by-enhancing-fear-associated-with-a-safety-cue-via-the-dorsal-hippocampus
#13
David A Connor, Munir G Kutlu, Thomas J Gould
Learned safety, a learning process in which a cue becomes associated with the absence of threat, is disrupted in individuals with post-traumatic stress disorder (PTSD). A bi-directional relationship exists between smoking and PTSD and one potential explanation is that nicotine-associated changes in cognition facilitate PTSD emotional dysregulation by disrupting safety associations. Therefore, we investigated whether nicotine would disrupt learned safety by enhancing fear associated with a safety cue. In the present study, C57BL/6 mice were administered acute or chronic nicotine and trained over three days in a differential backward trace conditioning paradigm consisting of five trials of a forward conditioned stimulus (CS)+ (Light) co-terminating with a footshock unconditioned stimulus followed by a backward CS- (Tone) presented 20 s after cessation of the unconditioned stimulus...
July 2017: Journal of Psychopharmacology
https://www.readbyqxmd.com/read/28669771/antidiabetic-antioxidant-and-anti-inflammatory-properties-of-water-and-n-butanol-soluble-extracts-from-saharian-anvillea-radiata-in-high-fat-diet-fed-mice
#14
Chouaib Kandouli, Mathieu Cassien, Anne Mercier, Caroline Delehedde, Emilie Ricquebourg, Pierre Stocker, Mourad Mekaouche, Zineb Leulmi, Aicha Mechakra, Sophie Thétiot-Laurent, Marcel Culcasi, Sylvia Pietri
ETHNOPHARMACOLOGICAL RELEVANCE: According to Saharian traditional medicine, Anvillea radiata Coss. & Dur. (Asteraceae) has been valued for treating a variety of ailments such as gastro-intestinal, liver and pulmonary diseases, and has gained awareness for its beneficial effect on postprandial hyperglycemia. However, to best of our knowledge, no detailed study of the antidiabetic curative effects of this plant has been conducted yet. AIM OF THE STUDY: To determine the hypoglycemic and antidiabetic effect of dietary supplementation with Anvillea radiata extracts on high-fat-diet (HFD)-induced obesity and insulin resistance in C57BL/6J mice in relation with antioxidant, anti-inflammatory, pancreatic beta-cells and skeletal muscle protection, and digestive enzyme inhibiting properties...
July 31, 2017: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/28668281/disruption-of-glua2-phosphorylation-potentiates-stress-responsivity
#15
Alexandra S Ellis, Anne Q Fosnocht, Kelsey E Lucerne, Lisa A Briand
Cocaine addiction is characterized by persistent craving and addicts frequently relapse even after long periods of abstinence. Exposure to stress can precipitate relapse in humans and rodents. Stress and drug use can lead to common alterations in synaptic plasticity and these commonalities may contribute to the ability of stress to elicit relapse. These common changes in synaptic plasticity are mediated, in part, by alterations in the trafficking and stabilization of AMPA receptors. Exposure to both cocaine and stress can lead to alterations in protein kinase C-mediated phosphorylation of GluA2 AMPA subunits and thus alter the trafficking of GluA2-containing AMPARs...
June 28, 2017: Behavioural Brain Research
https://www.readbyqxmd.com/read/28668206/predictors-of-post-traumatic-stress-disorder-in-acutely-traumatized-older-adults
#16
EDITORIAL
Thomas C Neylan
No abstract text is available yet for this article.
June 2, 2017: American Journal of Geriatric Psychiatry
https://www.readbyqxmd.com/read/28667285/oxidative-stress-challenge-uncovers-trichloroacetaldehyde-hydrate-induced-mitoplasticity-in-autistic-and-control-lymphoblastoid-cell-lines
#17
Richard Eugene Frye, Shannon Rose, Rebecca Wynne, Sirish C Bennuri, Sarah Blossom, Kathleen M Gilbert, Lynne Heilbrun, Raymond F Palmer
Mitoplasticity occurs when mitochondria adapt to tolerate stressors. Previously we hypothesized that a subset of lymphoblastoid cell lines (LCLs) from children with autistic disorder (AD) show mitoplasticity (AD-A), presumably due to previous environmental exposures; another subset of AD LCLs demonstrated normal mitochondrial activity (AD-N). To better understand mitoplasticity in the AD-A LCLs we examined changes in mitochondrial function using the Seahorse XF96 analyzer in AD and Control LCLs after exposure to trichloroacetaldehyde hydrate (TCAH), an in vivo metabolite of the environmental toxicant and common environmental pollutant trichloroethylene...
June 30, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28666738/polydatin-protects-against-carbon-tetrachloride-induced-liver-fibrosis-in-mice
#18
Xinyi Zhao, Rui Li, Ying Liu, Xuehong Zhang, Min Zhang, Zhi Zeng, Limin Wu, Xuelin Gao, Tian Lan, Yiqing Wang
Reactive oxygen species (ROS) play a key role in chronic liver injury and fibrosis. Polydatin, a glucoside of resveratrol, has been shown to possess anti-oxidative bioactivity. It has been demonstrated that resveratrol has many therapeutic effects on liver disorders including liver fibrosis. Recent study showed that polydatin prevented acute liver injury after carbon tetrachloride (CCl4) induction. However, the protective effects of polydatin on chronic liver injury and fibrosis has not been understood. Thus, we aimed to determine the roles of polydatin in chronic liver injury and fibrosis...
June 27, 2017: Archives of Biochemistry and Biophysics
https://www.readbyqxmd.com/read/28665521/traumatic-stress-in-patients-with-acute-leukemia-a-prospective-cohort-study
#19
Gary Rodin, Amy Deckert, Eryn Tong, Lisa W Le, Anne Rydall, Aaron Schimmer, Charles R Marmar, Chris Lo, Camilla Zimmermann
OBJECTIVE: Acute leukemia (AL) is associated with an immediate threat to life, an unpredictable clinical course, and substantial physical suffering. Traumatic stress symptoms that may meet criteria for acute stress disorder (ASD) may be common and disabling in this context, but have received little clinical attention. We investigated the incidence over time and risk factors for traumatic stress symptoms and ASD in the 3 months following diagnosis or relapse of AL. METHODS: Individuals with AL were recruited at a tertiary cancer centre in Canada within one month of diagnosis or relapse...
June 30, 2017: Psycho-oncology
https://www.readbyqxmd.com/read/28660161/posttraumatic-stress-disorder-after-myocardial-infarction-and-coronary-artery-bypass-grafting
#20
REVIEW
Amitoj Singh, Sahil Agrawal, Sanchita Gargya, Sabir Saluja, Akshat Kumar, Abhishek Kumar, Kartik Kalra, Munveer Thind, Sajeev Saluja, Lauren E Stone, Farhan Ali, Rodrigo Duarte-Chavez, Christine Marchionni, Farhad Sholevar, Jamshid Shirani, Sudip Nanda
Post traumatic stress disorder is a psychiatric disease that is usually precipitated by life threatening stressors. Myocardial infarction, especially in the young can count as one such event. The development of post traumatic stress after a coronary event not only adversely effects psychiatric health, but leads to increased cardiovascular morbidity and mortality. There is increasing evidence that like major depression, post traumatic stress disorder is also a strong coronary risk factor. Early diagnosis and treatment of this disease in patients with acute manifestations of coronary artery disease can improve patient outcomes...
April 2017: International Journal of Critical Illness and Injury Science
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