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Fam3

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https://www.readbyqxmd.com/read/27914282/fam3c-modulates-osteogenic-differentiation-by-down-regulating-runx2
#1
Ameya Bendre, Kalman G Büki, Jorma A Määttä
Fam3c, a cytokine-like protein, is a member of the Fam3 family (family with sequence similarity 3) and has been implicated to play a crucial role in Epithelial-to- mesenchymal transition (EMT) and subsequent metastasis during cancer progression. A few independent genome-wide association studies on different population cohorts predicted the gene locus of Fam3c to be associated with bone mineral density and fractures. In this study, we examined the role of Fam3c during osteoblast differentiation. Fam3c was found to be expressed during osteogenic differentiation of both primary bone marrow stromal cells and MC3T3-E1 pre-osteoblasts...
November 30, 2016: Differentiation; Research in Biological Diversity
https://www.readbyqxmd.com/read/27394190/quantitative-proteomic-profiling-reveals-hepatic-lipogenesis-and-liver-x-receptor-activation-in-the-pander-transgenic-model
#2
Mark G Athanason, Whitney A Ratliff, Dale Chaput, Catherine B MarElia, Melanie N Kuehl, Stanley M Stevens, Brant R Burkhardt
PANcreatic-DERived factor (PANDER) is a member of a superfamily of FAM3 proteins modulating glycemic levels by metabolic regulation of the liver and pancreas. The precise PANDER-induced hepatic signaling mechanism is still being elucidated and has been very complex due to the pleiotropic nature of this novel hormone. Our PANDER transgenic (PANTG) mouse displays a selective hepatic insulin resistant (SHIR) phenotype whereby insulin signaling is blunted yet lipogenesis is increased, a phenomena observed in type 2 diabetes...
November 15, 2016: Molecular and Cellular Endocrinology
https://www.readbyqxmd.com/read/26966188/identification-of-fam3d-as-a-new-endogenous-chemotaxis-agonist-for-the-formyl-peptide-receptors
#3
Xinjian Peng, Enquan Xu, Weiwei Liang, Xiaolei Pei, Dixin Chen, Danfeng Zheng, Yang Zhang, Can Zheng, Pingzhang Wang, Shaoping She, Yan Zhang, Jing Ma, Xiaoning Mo, Yingmei Zhang, Dalong Ma, Ying Wang
The family with sequence similarity 3 (FAM3) gene family is a cytokine-like gene family with four members FAM3A, FAM3B, FAM3C and FAM3D. In this study, we found that FAM3D strongly chemoattracted human peripheral blood neutrophils and monocytes. To identify the FAM3D receptor, we used chemotaxis, receptor internalization, Ca(2+) flux and radioligand-binding assays in FAM3D-stimulated HEK293 cells that transiently expressed formyl peptide receptor (FPR)1 or FPR2 to show that FAM3D was a high affinity ligand of these receptors, both of which were highly expressed on the surface of neutrophils, and monocytes and macrophages...
May 1, 2016: Journal of Cell Science
https://www.readbyqxmd.com/read/26492522/fam3a-protects-ht22-cells-against-hydrogen-peroxide-induced-oxidative-stress-through-activation-of-pi3k-akt-but-not-mek-erk-pathway
#4
Qing Song, Wen-Li Gou, Rong Zhang
BACKGROUND/AIMS: Oxidative stress-induced cell damage is involved in many neurological diseases. FAM3A is the first member of family with sequence similarity 3 (FAM3) gene family and its biological function remains largely unknown. METHODS: This study aimed to determine its role in hydrogen peroxide (H2O2) induced injury in neuronal HT22 cells. The protective effects were measured by cell viability, lactate dehydrogenase (LDH) release and apoptosis, and oxidative stress was assayed by reactive oxygen species (ROS) generation, ATP synthesis and lipid peroxidation...
2015: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/24857820/fam3a-promotes-vascular-smooth-muscle-cell-proliferation-and-migration-and-exacerbates-neointima-formation-in-rat-artery-after-balloon-injury
#5
Shi Jia, Zhenzhen Chen, Jing Li, Yujing Chi, Jinyu Wang, Sha Li, Yanjin Luo, Bin Geng, Cheng Wang, Qinghua Cui, Youfei Guan, Jichun Yang
The biological function of FAM3A, the first member of family with sequence similarity 3 (FAM3) gene family, remains largely unknown. This study aimed to determine its role in the proliferation and migration of vascular smooth muscle cells (VSMCs). Immunohistochemical staining revealed that FAM3A protein is expressed in the tunica media of rodent arteries, and its expression is reduced with an increase in prostaglandin E receptor 2 (EP2) expression after injury. In vitro, FAM3A overexpression promotes proliferation and migration of VSMCs, whereas FAM3A silencing inhibits these processes...
September 2014: Journal of Molecular and Cellular Cardiology
https://www.readbyqxmd.com/read/23855304/family-with-sequence-similarity-3-gene-family-and-nonalcoholic-fatty-liver-disease
#6
REVIEW
Jichun Yang, Youfei Guan
Nonalcoholic fatty liver disease (NAFLD) comprises a disease spectrum ranging from simple steatosis (fatty liver) and nonalcoholic steatohepatitis to fibrosis and cirrhosis. NAFLD has become the leading cause of chronic liver diseases as well as liver-related morbidity and mortality worldwide. NAFLD is also associated with increased risk of cardiovascular diseases, hyperlipidemia, and type 2 diabetes. Insulin resistance in adipose tissues and the liver plays crucial roles in the progression of NAFLD. The family with sequence similarity 3 (FAM3) gene family is a cytokine-like gene family with four members designated FAM3A, FAM3B, FAM3C, and FAM3D, respectively...
August 2013: Journal of Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/23671995/-the-latest-research-progress-on-fam3-gene-family
#7
REVIEW
Yan-Lan Zhou, Chun-Jiong Wang, Shi Jia
No abstract text is available yet for this article.
February 2013: Sheng Li Ke Xue Jin Zhan [Progress in Physiology]
https://www.readbyqxmd.com/read/23562554/fam3a-is-a-target-gene-of-peroxisome-proliferator-activated-receptor-gamma
#8
Yanlan Zhou, Shi Jia, Chunjiong Wang, Zhenzhen Chen, Yujing Chi, Jing Li, Guoheng Xu, Youfei Guan, Jichun Yang
BACKGROUND: To date, the biological function of FAM3A, the first member of FAM3 gene family, remains unknown. We aimed to investigate whether the expression of FAM3A in liver cells is regulated by peroxisome proliferator-activated receptors (PPARs). METHODS AND RESULTS: The transcriptional activity of human and mouse FAM3A gene promoters was determined by luciferase reporter assay system. PPARγ agonist rosiglitazone induced FAM3A expression in primary cultured mouse hepatocytes and human HepG2 cells...
August 2013: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/23333428/fam3b-pander-and-fam3c-ilei-represent-a-distinct-class-of-signaling-molecules-with-a-non-cytokine-like-fold
#9
Patrik Johansson, Jenny Bernström, Tracy Gorman, Linda Oster, Stefan Bäckström, Fritz Schweikart, Bingze Xu, Yafeng Xue, Lovisa Holmberg Schiavone
The FAM3 superfamily is predicted to contain classical four-helix bundle cytokines, featuring a typical up-up-down-down fold. Two members of FAM3 have been extensively studied. FAM3B PANDER has been shown to regulate glucose homeostasis and β cell function, whereas the homologous FAM3C ILEI has been shown to be involved in epithelial-mesenchymal transition and cancer. Here, we present a three-dimensional structure of a FAM3 protein, murine PANDER. Contrary to previous suggestions, PANDER exhibits a globular β-β-α fold...
February 5, 2013: Structure
https://www.readbyqxmd.com/read/21664909/pancreatic-derived-factor-novel-hormone-pandering-to-glucose-regulation
#10
REVIEW
Camella G Wilson, Claudia E Robert-Cooperman, Brant R Burkhardt
PANcreatic-DERived factor (PANDER, FAM3B) is a member of the FAM3 family of cytokine molecules that were initially described in 2002. PANDER expression is primarily localized to the endocrine pancreas and is secreted from both pancreatic α and β-cells. Initial characterization of PANDER revealed a potential role in pancreatic islet apoptosis. However, recent animal models have indicated PANDER functions as a hormone by regulating glucose levels via interaction with both the liver and the endocrine pancreas...
July 21, 2011: FEBS Letters
https://www.readbyqxmd.com/read/16406369/gg-a-domain-involved-in-phage-ltf-apparatus-and-implicated-in-human-meb-and-non-syndromic-hearing-loss-diseases
#11
Jinhu Guo, Haipeng Cheng, Shouyuan Zhao, Long Yu
Here, we report the identification of a novel domain--GG (domain in KIAA1199, FAM3, POMGnT1 and Tmem2 proteins, with two well-conserved glycine residues), present in eukaryotic FAM3 superfamily (FAM3A, FAM3B, FAM3C and FAM3D), POMGnT1 (protein O-linked mannose beta-1,2-N-acetylglucosaminyltransferase), TEM2 proteins as well as phage gp35 proteins. GG domain has been revealed to be implicated in muscle-eye-brain disease and non-syndromic hearing loss. The presence of GG domain in Bacteriophage gp35 hinge connector of long tail fiber might reflect the horizontal gene transfer from organisms...
January 23, 2006: FEBS Letters
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