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https://www.readbyqxmd.com/read/29443933/mental-health-interventions-for-parent-carers-of-children-with-autistic-spectrum-disorder-practice-guidelines-from-a-critical-interpretive-synthesis-cis-systematic-review
#1
REVIEW
Denise Catalano, Linda Holloway, Elias Mpofu
Parent carers of children with Autism Spectrum Disorder (ASD) often report increased levels of stress, depression, and anxiety. Unmet parent carer mental health needs pose a significant risk to the psychological, physical, and social well-being of the parents of the child affected by ASD and jeopardize the adaptive functioning of the family as well as the potential of the child affected by ASD. This systematic review identifies key qualities of interventions supporting the mental health of parent carers and proposes practitioner-parent carer support guidelines...
February 14, 2018: International Journal of Environmental Research and Public Health
https://www.readbyqxmd.com/read/29439664/heart-rate-defined-sustained-attention-in-infants-at-risk-for-autism
#2
Bridgette L Tonnsen, John E Richards, Jane E Roberts
BACKGROUND: Although aberrant visual attention has been identified in infants at high familial risk for autism, the developmental emergence of atypical attention remains unclear. Integrating biological measures of attention into prospective high-risk infant studies may inform more nuanced developmental trajectories, clarifying the onset and course of atypical attention and potentially advancing early screening or treatment protocols. Heart rate-defined sustained attention (HRDSA) is a well-validated biological measure of attentional engagement that, in non-clinical infant populations, provides incremental information about attentional engagement beyond looking behaviors alone...
February 13, 2018: Journal of Neurodevelopmental Disorders
https://www.readbyqxmd.com/read/29439610/outpatient-procedural-sedation-of-patients-with-autism-spectrum-disorders-for-magnetic-resonance-imaging-of-the-brain-using-propofol
#3
Pradip P Kamat, Marie K Karaga, Benjamin L Wisniewski, Courtney E McCracken, Harold K Simon, Reet Sidhu, Jocelyn R Grunwell
OBJECTIVE: To quantify the number of personnel, time to induce and complete sedation using propofol for outpatient magnetic resonance imaging (MRI) of the brain, and the frequency of serious adverse events (SAEs) in children with autism spectrum disorder (ASD) compared with children without ASD. RESULTS: Baseline characteristics were the same between both groups. Overall sedation success was 99%. Although most children were sedated with ≤3 providers, 10% with ASD needed ≥4 providers (P = ...
January 1, 2018: Journal of Child Neurology
https://www.readbyqxmd.com/read/29439467/blood-mitochondrial-dna-content-in-hiv-exposed-uninfected-children-with-autism-spectrum-disorder
#4
Matthew A Budd, Kristina Calli, Lindy Samson, Jennifer Bowes, Anthony Y Y Hsieh, John C Forbes, Ari Bitnun, Joel Singer, Fatima Kakkar, Ariane Alimenti, Evelyn J Maan, M E Suzanne Lewis, Carole Gentile, Hélène C F Côté, Jason C Brophy
Long-term outcomes of perinatal exposure to maternal antiretroviral therapy in HIV-exposed uninfected (HEU) children are unknown. However, both HIV antiretroviral therapy and autism spectrum disorder (ASD) have been associated with mitochondrial alterations. Leukocyte mitochondrial DNA (mtDNA) content can serve as a marker for mitochondrial dysfunction. In this cross-sectional, nested case-control study, HEU children with ASD were matched approximately 1:3 on age, sex, and ethnicity to HEU children without ASD, HIV-unexposed uninfected (HUU) controls, and HUU children with ASD...
February 11, 2018: Viruses
https://www.readbyqxmd.com/read/29438910/is-there-a-generalized-timing-impairment-in-autism-spectrum-disorders-across-time-scales-and-paradigms
#5
Sofia Isaksson, Susanna Salomäki, Jarno Tuominen, Valtteri Arstila, Christine M Falter-Wagner, Valdas Noreika
Individuals with ASD have abnormal motor and perceptual functions that do not currently form diagnostic criteria of ASD, but nevertheless may affect everyday behaviour. Temporal processing seems to be one of such non-diagnostic yet impaired domains, although the lack of systematic studies testing different aspects of timing in the same sample of participants prevents a conclusive assessment of whether there is a generalized temporal deficit in ASD associated with diagnostic symptoms. 17 children diagnosed with ASD and 18 typically developing age- and IQ-matched controls carried out a set of motor and perceptual timing tasks: free tapping, simultaneity judgment, auditory duration discrimination, and verbal duration estimation...
February 10, 2018: Journal of Psychiatric Research
https://www.readbyqxmd.com/read/29437299/proneness-to-guilt-shame-and-pride-in-children-with-autism-spectrum-disorders-and-neurotypical-children
#6
Denise Davidson, Elizabeth Hilvert, Ieva Misiunaite, Michael Giordano
Self-conscious emotions (e.g., guilt, shame, and pride) are complex emotions that require self-reflection and self-evaluation, and are thought to facilitate the maintenance of societal norms and personal standards. Despite the importance of self-conscious emotions, most research has focused on basic emotion processing in children with Autism Spectrum Disorders (ASD). Therefore, in the present study, we used the Test of Self-Conscious Affect for Children (TOSCA-C) to assess proneness to, or propensity to experience, the self-conscious emotions guilt, shame, and pride in children with ASD and neurotypical children...
February 13, 2018: Autism Research: Official Journal of the International Society for Autism Research
https://www.readbyqxmd.com/read/29437021/homocysteine-levels-in-autism-spectrum-disorder-a-clinical-update
#7
Milagros Fuentes-Albero, Omar Cauli
Homocysteine (Hcy) is a non-protein α-amino acid, which plays several important roles in human physiology and in the central nervous system. Although Hcy has several known biological properties in one-carbon metabolism, its overproduction might be harmful and could add to the pathophysiology associated with autism spectrum disorder (ASD). This review presents updated information about alterations in the concentration of this amino acid in biological fluids (blood and urine) in patients with ASD. In addition, we assessed its clinical significance by analyzing if there are any potential associations between abnormal Hcy levels and the severity ASD or any of its symptoms...
February 12, 2018: Endocrine, Metabolic & Immune Disorders Drug Targets
https://www.readbyqxmd.com/read/29436887/machine-learning-in-autistic-spectrum-disorder-behavioral-research-a-review-and-ways-forward
#8
Fadi Thabtah
Autistic Spectrum Disorder (ASD) is a mental disorder that retards acquisition of linguistic, communication, cognitive, and social skills and abilities. Despite being diagnosed with ASD, some individuals exhibit outstanding scholastic, non-academic, and artistic capabilities, in such cases posing a challenging task for scientists to provide answers. In the last few years, ASD has been investigated by social and computational intelligence scientists utilizing advanced technologies such as machine learning to improve diagnostic timing, precision, and quality...
February 13, 2018: Informatics for Health & Social Care
https://www.readbyqxmd.com/read/29436876/the-relationship-between-anxiety-external-structure-behavioral-history-and-becoming-locked-into-restricted-and-repetitive-behaviors-in-autism-spectrum-disorder
#9
Andrew Cashin, James Yorke
Restricted and repetitive behaviors (RRBs) are central to the diagnosis of autism spectrum disorder (ASD), yet there remains a paucity of research in this domain. What is clear is that people with ASD are vulnerable to getting locked into rigid patterns of thought and behavior that contribute to a lack of adaptation. This study utilized an online survey to explore the relationship between anxiety, external structure, the measurement of RRBs and behavioral history of being locked into RRBs. A significant relationship was identified between level of anxiety and a history of becoming locked into RRBs...
February 13, 2018: Issues in Mental Health Nursing
https://www.readbyqxmd.com/read/29436853/electrophysiological-response-during-auditory-gap-detection-biomarker-for-sensory-and-communication-alterations-in-autism-spectrum-disorder
#10
Jennifer H Foss-Feig, Katherine K M Stavropoulos, James C McPartland, Mark T Wallace, Wendy L Stone, Alexandra P Key
Sensory symptoms, including auditory processing deficits, are common in autism spectrum disorder (ASD). Processing of temporal aspects of auditory input is understudied; yet, deficits in this domain could contribute to language-related impairments. In children with ASD and well-matched controls, this study examined electrophysiological response to silent gaps in auditory stimuli. Results revealed attenuated amplitude of the P2 event-related potential (ERP) component in ASD. The P2 amplitude reduction was also associated with sensory, language, and diagnostic features...
2018: Developmental Neuropsychology
https://www.readbyqxmd.com/read/29436313/pre-eclampsia-and-the-risk-of-autism-spectrum-disorder-in-offspring-meta-analysis
#11
Berihun Assefa Dachew, Abdullah Mamun, Joemer Calderon Maravilla, Rosa Alati
BACKGROUND: Evidence about the effect of intrauterine exposure to pre-eclampsia on offspring autism-spectrum disorder (ASD) is not well established. Aims To examine the association between pre-eclampsia and ASD. METHOD: PubMed, Embase and PsycINFO databases were searched. Pooled relative risks (RR) with 95% confidence intervals were calculated. Subgroup and sensitivity analyses were performed. Heterogeneity was assessed using Cochran's Q- and the I 2-test. The presence of publication bias was evaluated by Egger's test and visual inspection of the symmetry in funnel plots...
January 24, 2018: British Journal of Psychiatry: the Journal of Mental Science
https://www.readbyqxmd.com/read/29435595/-blood-management-in-complex-reconstructive-spine-surgery-in-asd-patients-do-effective-measures-to-reduce-bleeding-exist
#12
REVIEW
V Bullmann, M Granitzka
BACKGROUND: Blood management in reconstructive spine surgery is a challenge and must be managed interdisciplinarily. An experienced team of anesthesiologists and spine surgeons needs to work closely together. THERAPY: After optimal preoperative preparation, the patient is given an initial dose of 1000 mg tranexamic acid. The most adequate medium blood pressure is about 80 mm Hg during surgery. The surgeon must watch for subperiosteal preparation and subtle stypsis...
February 12, 2018: Der Orthopäde
https://www.readbyqxmd.com/read/29435580/association-of-prenatal-ultrasonography-and-autism-spectrum-disorder
#13
N Paul Rosman, Rachel Vassar, Gheorghe Doros, James DeRosa, Allison Froman, Audrey DiMauro, Sherry Santiago, Jodi Abbott
Importance: The prevalence of autism spectrum disorder (ASD) has been increasing rapidly, with current estimates of 1 in 68 children affected. Simultaneously, use of prenatal ultrasonography has increased substantially, with limited investigation into its safety and effects on brain development. Animal studies have demonstrated that prenatal ultrasonography can adversely affect neuronal migration. Objective: To quantify prenatal ultrasound exposure by the frequency, timing, duration, and strength of ultrasonographic scans in children with later ASD, developmental delay, and typical development...
February 12, 2018: JAMA Pediatrics
https://www.readbyqxmd.com/read/29434036/damaging-de-novo-mutations-diminish-motor-skills-in-children-on-the-autism-spectrum
#14
Andreas Buja, Natalia Volfovsky, Abba M Krieger, Catherine Lord, Alex E Lash, Michael Wigler, Ivan Iossifov
In individuals with autism spectrum disorder (ASD), de novo mutations have previously been shown to be significantly correlated with lower IQ but not with the core characteristics of ASD: deficits in social communication and interaction and restricted interests and repetitive patterns of behavior. We extend these findings by demonstrating in the Simons Simplex Collection that damaging de novo mutations in ASD individuals are also significantly and convincingly correlated with measures of impaired motor skills...
February 6, 2018: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/29433607/developmental-coordination-disorder-psychopathology-and-iq-in-22q11-2-deletion-syndrome
#15
Adam C Cunningham, Sue Delport, Wendy Cumines, Monica Busse, David E J Linden, Jeremy Hall, Michael J Owen, Marianne B M van den Bree
BACKGROUND: 22q11.2 deletion syndrome (22q11.2DS) is associated with high rates of neurodevelopmental disorder, however, the links between developmental coordination disorder (DCD), intellectual function and psychiatric disorder remain unexplored. Aims To establish the prevalence of indicative DCD in children with 22q11.2DS and examine associations with IQ, neurocognition and psychopathology. METHOD: Neurocognitive assessments and psychiatric interviews of 70 children with 22q11...
January 2018: British Journal of Psychiatry: the Journal of Mental Science
https://www.readbyqxmd.com/read/29432197/echocardiographic-assessment-of-left-to-right-shunts-atrial-septal-defect-ventricular-septal-defect-atrioventricular-septal-defect-patent-arterial-duct
#16
REVIEW
Antigoni Deri, Kate English
This review article will guide the reader through the basics of echocardiographic assessment of congenital left to right shunts in both paediatric and adult age groups. After reading this article the reader will understand the pathology and clinical presentation of atrial septal defects (ASDs), ventricular septal defects (VSDs), atrioventricular septal defects (AVSDs) and patent ductus arteriosus (PDA). In times gone by the stethoscope was the primary diagnostic tool used to diagnose these lesions, but in today's clinicians those skills have been usurped by the superiority of the trans-thoracic echo probe...
February 5, 2018: Echo Research and Practice
https://www.readbyqxmd.com/read/29432106/a-feasibility-study-of-autism-behavioral-markers-in-spontaneous-facial-visual-and-hand-movement-response-data
#17
Manar D Samad, Norou Diawara, Jonna L Bobzien, John W Harrington, Megan A Witherow, Khan M Iftekharuddin
Autism spectrum disorder (ASD) is a neurodevelopmental disability with atypical traits in behavioral and physiological responses. These atypical traits in individuals with ASD may be too subtle and subjective to measure visually using tedious methods of scoring. Alternatively, the use of intrusive sensors in the measurement of psychophysical responses in individuals with ASD may likely cause inhibition and bias. This paper proposes a novel experimental protocol for non-intrusive sensing and analysis of facial expression, visual scanning, and eye-hand coordination to investigate behavioral markers for ASD...
February 2018: IEEE Transactions on Neural Systems and Rehabilitation Engineering
https://www.readbyqxmd.com/read/29431564/transferring-picture-exchange-requests-to-receptive-identification-for-children-with-asd
#18
Jennifer Ninci, Mandy Rispoli, Leslie C Neely, Samantha Guz
The purpose of this study was to evaluate a procedure to transfer stimulus control from picture exchange requests to receptive identification. Three children with autism spectrum disorder (ASD) and absent receptive identification repertoires participated. An adapted alternating treatment design was used. During intervention, two high-preferred and two low-preferred targets were available during picture exchange requesting sessions. Participants requested primarily for one or both high-preferred targets. During receptive identification instructional sessions, one participant acquired one high-preferred target, one participant acquired all targets, and one participant demonstrated no improvements...
February 12, 2018: Developmental Neurorehabilitation
https://www.readbyqxmd.com/read/29431296/utility-of-incomplete-right-bundle-branch-block-as-an-isolated-ecg-finding-in-children-undergoing-initial-cardiac-evaluation
#19
Omar Meziab, Dominic J Abrams, Mark E Alexander, Laura Bevilacqua, Vassilios Bezzerides, Doug Y Mah, Edward P Walsh, John K Triedman
OBJECTIVE: This study evaluates the ability of experienced pediatric electrophysiologists (EPs) to reliably classify incomplete right bundle branch block (IRBBB) and assesses its clinical utility as an isolated ECG finding in a group of healthy outpatient children without prior cardiac evaluation. DESIGN: We performed a retrospective analysis of all electrocardiographic and echocardiographic records at Boston Children's Hospital between January 1, 2005, and December 31, 2014...
February 12, 2018: Congenital Heart Disease
https://www.readbyqxmd.com/read/29430430/airway-improvement-with-medium-term-compression-duration-after-right-pulmonary-artery-anterior-translocation
#20
Woo Sung Jang, Jae Bum Kim, Jae Hyun Kim, Hee Jeong Choi
Left main bronchus compression occasionally occurs in patients with cardiac disease. A 19-month-old female patient weighing 6.7 kg was admitted for recurrent pneumonia and desaturation. She had an a trial septal defect (AS D) with a right aortic arch. Her left main bronchus had been compressed between the enlarged right pulmonary artery (RPA) and the descending thoracic aorta for 14 months. We conducted ASD closure and RPA anterior translocation via sternotomy. The left main bronchus compression was relieved despite the medium-term duration of compression...
February 2018: Korean Journal of Thoracic and Cardiovascular Surgery
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