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https://www.readbyqxmd.com/read/29659672/adi-peg-20-plus-best-supportive-care-versus-placebo-plus-best-supportive-care-in-patients-with-advanced-hepatocellular-carcinoma
#1
G Abou-Alfa, S Qin, B-Y Ryoo, S-N Lu, C-J Yen, Y-H Feng, H Y Lim, F Izzo, M Colombo, D Sarker, L Bolondi, G Vaccaro, W P Harris, Z Chen, R A Hubner, T Meyer, W Sun, J J Harding, E M Hollywood, J Ma, P J Wan, M Ly, J Bomalaski, A Johnston, C-C Lin, Y Chao, L-T Chen
Background: Arginine depletion is a putative target in hepatocellular carcinoma (HCC). HCC often lacks argininosuccinate synthetase, a citrulline to arginine-repleting enzyme. ADI-PEG 20 is a cloned arginine degrading enzyme - arginine deiminase - conjugated with polyethylene glycol. The goal of this study was to evaluate this agent as a potential novel therapeutic for HCC after first line systemic therapy. Methods and Patients: Patients with histologically proven advanced HCC and Child-Pugh up to B7 with prior systemic therapy, were randomized 2:1 to ADI-PEG 20 18 mg/m2 vs...
April 5, 2018: Annals of Oncology: Official Journal of the European Society for Medical Oncology
https://www.readbyqxmd.com/read/29628378/pegvaliase-for-the-treatment-of-phenylketonuria-a-pivotal-double-blind-randomized-discontinuation-phase-3-clinical-trial
#2
Cary O Harding, R Stephen Amato, Mary Stuy, Nicola Longo, Barbara K Burton, John Posner, Haoling H Weng, Markus Merilainen, Zhonghua Gu, Joy Jiang, Jerry Vockley
INTRODUCTION: Pegvaliase is a recombinant Anabaena variabilis phenylalanine ammonia lyase (PAL) enzyme under investigation for treatment of adult phenylketonuria (PKU). This manuscript describes results of a randomized discontinuation trial (RDT) designed to evaluate the effects of pegvaliase treatment on blood phenylalanine (Phe) and neuropsychiatric outcomes in adults with PKU. METHODS: PRISM-2 is a 4-part, Phase 3 study that enrolled adults with PKU receiving pegvaliase treatment (initiated in a prior Phase 2 or Phase 3 study)...
March 18, 2018: Molecular Genetics and Metabolism
https://www.readbyqxmd.com/read/29627120/attending-diabetes-clinics-is-associated-with-a-lower-all-cause-mortality-a-meta-analysis-of-observational-studies-performed-in-italy
#3
E Bonora, M Monami, G Bruno, G Zoppini, E Mannucci
OBJECTIVE: The epidemiological explosion of diabetes is a challenge for Health Systems and the identification of the most appropriate models of care are warranted. The inclusion of primary care physicians in the models is unquestioned whereas the role played by secondary and tertiary care (Diabetes Clinic) is often debated. However, studies focusing on hard endpoints and comparing Diabetes Clinic attendance vs. no attendance are scant. RESEARCH DESIGN AND METHODS: A meta-analysis was performed including all observational cohort studies performed in Italy, reporting crude and/or adjusted estimates of all-cause mortality in patients with diabetes attending or not attending Diabetes Clinics...
March 2, 2018: Nutrition, Metabolism, and Cardiovascular Diseases: NMCD
https://www.readbyqxmd.com/read/29533391/a-dataset-on-human-navigation-strategies-in-foreign-networked-systems
#4
Attila Kőrösi, Attila Csoma, Gábor Rétvári, Zalán Heszberger, József Bíró, János Tapolcai, István Pelle, Dávid Klajbár, Márton Novák, Valentina Halasi, András Gulyás
Humans are involved in various real-life networked systems. The most obvious examples are social and collaboration networks but the language and the related mental lexicon they use, or the physical map of their territory can also be interpreted as networks. How do they find paths between endpoints in these networks? How do they obtain information about a foreign networked world they find themselves in, how they build mental model for it and how well they succeed in using it? Large, open datasets allowing the exploration of such questions are hard to find...
March 13, 2018: Scientific Data
https://www.readbyqxmd.com/read/29520449/cardiac-ct-in-the-emergency-department-contrasting-evidence-from-registries-and-randomized-controlled-trials
#5
REVIEW
Nam Ju Lee, Harold Litt
PURPOSE OF REVIEW: To compare outcomes between registries and randomized controlled trials of coronary computed tomographic angiography (CCTA)-based versus standard of care approaches to the initial evaluation of patients with acute chest pain. RECENT FINDINGS: Randomized trials have demonstrated CCTA to be a safe and efficient tool for triage of low- to intermediate-risk patients presenting to the emergency department with chest pain. Recent studies demonstrate heterogeneous result using different standard of care approaches for evaluation of hard endpoints in comparison with standard evaluation...
March 8, 2018: Current Cardiology Reports
https://www.readbyqxmd.com/read/29516192/randomized-controlled-trial-of-remote-ischaemic-conditioning-in-st-elevation-myocardial-infarction-as-adjuvant-to-primary-angioplasty-ric-stemi
#6
António Gaspar, André P Lourenço, Miguel Álvares Pereira, Pedro Azevedo, Roberto Roncon-Albuquerque, Jorge Marques, Adelino F Leite-Moreira
To test whether remote ischaemic conditioning (RIC) as adjuvant to standard of care (SOC) would prevent progression towards heart failure (HF) after ST-elevation myocardial infarction (STEMI). Single-centre parallel 1:1 randomized trial (computerized block-randomization, concealed allocation) to assess superiority of RIC (3 cycles of intermittent 5 min lower limb ischaemia) over SOC in consecutive STEMI patients (NCT02313961, clinical trials.gov). From 258 patients randomized to RIC or SOC, 9 and 4% were excluded because of unconfirmed diagnosis and previously unrecognized exclusion criteria, respectively...
March 7, 2018: Basic Research in Cardiology
https://www.readbyqxmd.com/read/29514605/predictive-value-of-spot-versus-24-hour-measures-of-proteinuria-for-death-end-stage-kidney-disease-or-chronic-kidney-disease-progression
#7
Tracey Ying, Philip Clayton, Chetana Naresh, Steven Chadban
BACKGROUND: Proteinuria is well recognised as a marker of chronic kidney disease (CKD), as a risk factor for progression of CKD among those with known CKD, and as a risk factor for cardiovascular events and death among both the general and CKD populations. Which measure of proteinuria is most predictive of renal events remains uncertain. METHODS: We conducted a prospective study with 144 proteinuric CKD and kidney transplant recipients attending an outpatient clinic of a tertiary care hospital in Australia...
March 7, 2018: BMC Nephrology
https://www.readbyqxmd.com/read/29512600/a-meta-analysis-to-assess-usefulness-of-procalcitonin-guided-antibiotic-usage-for-decision-making
#8
REVIEW
Nusrat Shafiq, Vikas Gautam, Avaneesh Kumar Pandey, Navjot Kaur, Shubha Garg, Harish Negi, Sharonjeet Kaur, Pallab Ray, Samir Malhotra
Background & objectives: Development of antibacterial resistance and its association with antibiotic overuse makes it necessary to identify a specific and sensitive biomarker for the diagnosis of bacterial infection and guiding antibiotic therapy. Procalcitonin (PCT), as a sepsis biomarker, may play a role in guiding antibiotics treatment in hospital settings. The aim of the current meta-analysis was to analyze the utility of PCT on various outcomes of interest in inpatients. Methods: Different databases were searched for randomized controlled trials comparing PCT-guided therapy with standard therapy in admitted patients with bacterial infections...
November 2017: Indian Journal of Medical Research
https://www.readbyqxmd.com/read/29509113/a-cost-effectiveness-analysis-of-a-hydration-response-technology-dressing-in-the-treatment-of-venous-leg-ulcers-in-the-uk
#9
Stefan Walzer, Daniel Dröschel, Lutz Vollmer, Leanne Atkin, Karen Ousey
OBJECTIVE: Venous leg ulcers (VLUs) cause significant pain and suffering for patients. Additionally, they place considerable financial and service burden on the National Health Service (NHS). A large proportion of VLUs do not heal within the standard time frame of 16-24 weeks, resulting in static wounds which commonly have issues with increasing exudate production. As the NHS continues to face times of austerity, services need to find solutions to be able to reduce costs and release nursing time while maintaining standards of care...
March 2, 2018: Journal of Wound Care
https://www.readbyqxmd.com/read/29487821/effects-of-lipid-lowering-agents-on-diabetic-retinopathy-a-meta-analysis-and-systematic-review
#10
Rui Shi, Lei Zhao, Feng Wang, Fen Liu, Zhuo Chen, Rong Li, Yang Liu, Rong Lin
AIM: To clarify this controversy and to provide evidence for application of lipid lowering agents in treatment of diabetic retinopathy (DR). METHODS: We searched the databases of PubMed, Embase and Cochrane Library Central Register of Controlled Trials (CENTRAL) and abstracts from main annual meetings up to January 1, 2017. Google scholar and ClinicalTrials.gov were also searched for unpublished relevant studies. We included randomized controlled trials (RCTs) that studied lipid-lowering agents in type 1 or type 2 diabetes in this Meta-analysis...
2018: International Journal of Ophthalmology
https://www.readbyqxmd.com/read/29478173/retrospective-review-of-arctic-front-advance-cryoballoon-ablation-a-multicenter-examination-of-second-generation-cryoballoon-radicool-trial
#11
Wilber Su, G Joseph Orme, Robert Hoyt, James Baker, Steven Compton, Christopher Fellows, John Harding, J Thomas Svinarich, Marcin Kowalski, Bryan Piedad, David Kenigsberg, John Seger, Zeshan K Ahmad, Paul Wang
BACKGROUND: Pulmonary vein isolation (PVI) via catheter ablation is an approved therapy for patients with drug-refractory and symptomatic atrial fibrillation (AF). Furthermore, cryoballoon is now considered to be as effective as focal radiofrequency catheter ablation. This study examines the second-generation cryoballoon performance in a US multicenter review of real-world practices. METHODS: By retrospective chart collections, the long-term efficacy and safety of the cryoballoon procedure were assessed in 15 US centers...
February 24, 2018: Journal of Interventional Cardiac Electrophysiology: An International Journal of Arrhythmias and Pacing
https://www.readbyqxmd.com/read/29478050/sodium-intake-and-blood-pressure-in-patients-with-chronic-kidney-disease-a-salty-relationship
#12
Fabiana B Nerbass, Viviane Calice-Silva, Roberto Pecoits-Filho
BACKGROUND: Hypertension affects almost all chronic kidney disease patients and is related to poor outcomes. Sodium intake is closely related to blood pressure (BP) levels in this population and decreasing its intake consistently improves the BP control particularly in short-term controlled trials. However, most patients struggle in following a controlled diet on sodium according to the guidelines recommendation due to several factors and barriers discussed in this article. SUMMARY: This review article summarizes the current knowledge related to the associations between sodium consumption, BP, and the risk of cardiovascular disease and chronic kidney disease (CKD); it also provides recommendations of how to achieve sodium intake lowering...
January 26, 2018: Blood Purification
https://www.readbyqxmd.com/read/29471459/descriptive-texture-analyses-of-broiler-breast-fillets-with-the-wooden-breast-condition-stored-at-4%C3%A2-c-and-20%C3%A2-c
#13
G Sanchez Brambila, B C Bowker, D Chatterjee, H Zhuang
The objective of this study was to evaluate the effects of the wooden breast (WB) condition on the texture of cooked broiler breast fillets (Pectoralis major) after fresh and frozen storage. Texture characteristics of normal (NORM) and severe WB fillets were studied by both sensory descriptive analyses and Warner-Bratzler shear force. Broiler breast fillets were collected over 3 separate trial days from a commercial deboning line at 3 h postmortem, classified according to the wooden breast condition, and then stored at either 4°C or -20°C prior to cooking and texture evaluation...
February 16, 2018: Poultry Science
https://www.readbyqxmd.com/read/29454776/cardiac-magnetic-resonance-myocardial-feature-tracking-for-optimized-prediction-of-cardiovascular-events-following-myocardial-infarction
#14
Ingo Eitel, Thomas Stiermaier, Torben Lange, Karl-Philipp Rommel, Alexander Koschalka, Johannes T Kowallick, Joachim Lotz, Shelby Kutty, Matthias Gutberlet, Gerd Hasenfuß, Holger Thiele, Andreas Schuster
OBJECTIVES: The aims of the study were to assess the prognostic significance of cardiac magnetic resonance myocardial feature tracking (CMR-FT) in a large multicenter study and to evaluate the most potent CMR-FT predictor of hard clinical events following myocardial infarction (MI). BACKGROUND: CMR-FT is a new method that allows accurate assessment of global and regional circumferential, radial, and longitudinal myocardial strain. The prognostic value of CMR-FT in patients with reperfused MI is unknown...
February 9, 2018: JACC. Cardiovascular Imaging
https://www.readbyqxmd.com/read/29384392/factors-associated-with-health-related-quality-of-life-in-stable-ambulatory-congestive-heart-failure-patients-systematic-review
#15
Anneleen Baert, Delphine De Smedt, Johan De Sutter, Dirk De Bacquer, Paolo Emilio Puddu, Els Clays, Sofie Pardaens
Background Since improved treatment of congestive heart failure has resulted in decreased mortality and hospitalisation rates, increasing self-perceived health-related quality of life (HRQoL) has become a major goal of congestive heart failure treatment. However, an overview on predictieve factors of HRQoL is currently lacking in literature. Purpose The aim of this study was to identify key factors associated with HRQoL in stable ambulatory patients with congestive heart failure. Methods A systematic review was performed...
January 1, 2018: European Journal of Preventive Cardiology
https://www.readbyqxmd.com/read/29373178/current-use-of-beta-blockers-in-patients-with-coronary-artery-disease
#16
REVIEW
Charlotte Andreasen, Charlotte Andersson
Beta-blockers have long comprised a cornerstone in the symptomatic treatment of ischemic heart disease and in the secondary prevention of myocardial infarction and heart failure. The majority of studies underlying the evidence of a beneficial effect of beta-blockers on outcomes were conducted more than 25 years ago. In a contemporary era where treatment strategies and secondary prophylactic therapy have undergone several changes, the continued role of beta-blockers in ischemic heart disease has been questioned, especially in the absence of heart failure or a recent myocardial infarction...
January 5, 2018: Trends in Cardiovascular Medicine
https://www.readbyqxmd.com/read/29365058/colorectal-cancer-crc-monitoring-by-six-monthly-18fdg-pet-ct-an-open-label-multicentre-randomised-trial
#17
I Sobhani, E Itti, A Luciani, I Baumgaertner, R Layese, T André, M Ducreux, J-M Gornet, G Goujon, T Aparicio, J Taieb, J-B Bachet, F Hemery, A Retbi, M Mons, R Flicoteaux, B Rhein, S Baron, I Cherrak, P Rufat, P Le Corvoisier, N De'Angelis, P-A Natella, H Maoulida, C Tournigand, I Durand Zaleski, S Bastuji-Garin
Background: 18FDG-PET/CT has high sensitivity for detecting recurrences of colorectal cancer (CRC). Our objective was to determine whether adding routine 6-monthly 18FDG-PET/CT to our usual monitoring strategy improved patient outcomes and to assess the effect on costs. Patients and Methods: In this open-label multicentre trial, patients in remission of CRC (stage II perforated, stage III, or stage IV) after curative surgery were randomly assigned (1:1) to usual monitoring alone (3-monthly physical and tumour marker assays, 6-monthly liver ultrasound and chest radiograph, and 6-monthly whole-body computed tomography) or with 6-monthly 18FDG-PET/CT, for 3 years...
January 22, 2018: Annals of Oncology: Official Journal of the European Society for Medical Oncology
https://www.readbyqxmd.com/read/29343271/p66shc-gene-expression-in-peripheral-blood-mononuclear-cells-and-progression-of-diabetic-complications
#18
Gian Paolo Fadini, Mattia Albiero, Benedetta Maria Bonora, Nicol Poncina, Saula Vigili de Kreutzenberg, Angelo Avogaro
BACKGROUND: The risk of diabetic complications is modified by genetic and epigenetic factors. p66Shc drives the hyperglycaemic cell damage and its deletion prevents experimental diabetic complications. We herein tested whether p66Shc expression in peripheral blood mononuclear cells (PBMCs) predicts adverse outcomes in people with diabetes. METHODS: In a cohort of 100 patients with diabetes (16 type 1 and 84 type 2), we quantified baseline p66Shc expression in PBMCs by quantitative PCR...
January 17, 2018: Cardiovascular Diabetology
https://www.readbyqxmd.com/read/29284411/prediction-of-posthepatectomy-liver-failure-using-transient-elastography-in-patients-with-hepatitis-b-related-hepatocellular-carcinoma
#19
Jie-Wen Lei, Xiao-Yu Ji, Jun-Feng Hong, Wan-Bin Li, Yan Chen, Yan Pan, Jia Guo
BACKGROUND: It is essential to accurately predict Postoperative liver failure (PHLF) which is a life-threatening complication. Liver hardness measurement (LSM) is widely used in non-invasive assessment of liver fibrosis. The aims of this study were to explore the application of preoperative liver stiffness measurements (LSM) by transient elastography in predicting postoperative liver failure (PHLF) in patients with hepatitis B related hepatocellular carcinoma. METHODS: The study included 247 consecutive patients with hepatitis B related hepatocellular carcinoma who underwent hepatectomy between May 2015 and September 2015...
December 29, 2017: BMC Gastroenterology
https://www.readbyqxmd.com/read/29245366/catheter-ablation-versus-rate-control-in-patients-with-atrial-fibrillation-and-heart-failure-a-multicenter-study
#20
MULTICENTER STUDY
Jin Geng, Yanchun Zhang, Yanhan Wang, Lijuan Cao, Jie Song, Bingjian Wang, Wei Song, Ju Li, Wei Xu
Many trials have shown improvements in left ventricular function, exercise capacity, and quality of life after catheter ablation (CA) of atrial fibrillation (AF) in patients with heart failure (HF). We sought to evaluate the impact of CA on hard outcomes in a retrospective cohort study. AF patients with symptomatic HF from 3 hospitals were included. Our primary endpoint was major adverse cardiac events (MACEs), a composite of all-cause mortality, stroke, and unplanned hospitalization. In total, 90 patients underwent CA and 304 ones received rate control (RaC) were included...
December 2017: Medicine (Baltimore)
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