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https://www.readbyqxmd.com/read/27852480/use-of-computed-tomography-to-guide-mitral-interventions
#1
REVIEW
Vladimir Jelnin, Chad Kliger, Fabio Zucchetta, Carlos E Ruiz
With increasing utilization of cardiac computed tomographic angiography (CTA) and widespread adoption of fusion imaging technology allowing the merger of pre-procedural CTA with fluoroscopy, the ability of CTA to guide structural heart interventions has evolved significantly. It has opened new possibilities in mitral valve (MV) interventions with improved pre-procedural planning and intra-procedural guidance. Given the lack of fluoroscopic landmarks of the mitral apparatus and continued growth of native MV device technologies, the value of CTA will continue to develop...
January 2016: Interventional cardiology clinics
https://www.readbyqxmd.com/read/27847254/vascular-calcification-in-ckd-mbd-roles-for-phosphate-fgf23-and-klotho
#2
REVIEW
Shunsuke Yamada, Cecilia M Giachelli
Vascular calcification (VC) is highly prevalent in aging, diabetes mellitus, and chronic kidney disease (CKD). VC is a strong predictor of cardiovascular morbidity and mortality in the CKD population. Complex pathological mechanisms are involved in the development of VC, including osteochondrogenic differentiation and apoptosis of vascular smooth muscle cells, instability and release of extracellular vesicles loaded calcium and phosphate, and elastin degradation. Elevated serum phosphate is a late manifestation of CKD, and has been shown to accelerate mineral deposition in both the vessel wall and heart valves...
November 12, 2016: Bone
https://www.readbyqxmd.com/read/27834758/current-status-of-tissue-engineering-heart-valve
#3
Toshiharu Shinoka, Hideki Miyachi
The development of surgically implantable heart valve prostheses has contributed to improved outcomes in patients with cardiovascular disease. However, there are drawbacks, such as risk of infection and lack of growth potential. Tissue-engineered heart valve (TEHV) holds great promise to address these drawbacks as the ideal TEHV is easily implanted, biocompatible, non-thrombogenic, durable, degradable, and ultimately remodels into native-like tissue. In general, three main components used in creating a tissue-engineered construct are (1) a scaffold material, (2) a cell type for seeding the scaffold, and (3) a subsequent remodeling process driven by cell accumulation and proliferation, and/or biochemical and mechanical signaling...
November 2016: World Journal for Pediatric & Congenital Heart Surgery
https://www.readbyqxmd.com/read/27789941/nanopatterned-acellular-valve-conduits-drive-the-commitment-of-blood-derived-multipotent-cells
#4
Rosa Di Liddo, Paola Aguiari, Silvia Barbon, Thomas Bertalot, Amit Mandoli, Alessia Tasso, Sandra Schrenk, Laura Iop, Alessandro Gandaglia, Pier Paolo Parnigotto, Maria Teresa Conconi, Gino Gerosa
Considerable progress has been made in recent years toward elucidating the correlation among nanoscale topography, mechanical properties, and biological behavior of cardiac valve substitutes. Porcine TriCol scaffolds are promising valve tissue engineering matrices with demonstrated self-repopulation potentiality. In order to define an in vitro model for investigating the influence of extracellular matrix signaling on the growth pattern of colonizing blood-derived cells, we cultured circulating multipotent cells (CMC) on acellular aortic (AVL) and pulmonary (PVL) valve conduits prepared with TriCol method and under no-flow condition...
2016: International Journal of Nanomedicine
https://www.readbyqxmd.com/read/27780149/nanofibrous-bioengineered-heart-valve-application-in-paediatric-medicine
#5
REVIEW
Mehrdad Namdari, Ali Eatemadi
Heart valves are currently under thorough investigation in tissue engineering (TE) research. Mechanical and biological heart valve prostheses which are recently used have several shortcomings. While allogenic and xenogenic biological prostheses are related to graft rejection, degeneration and thrombosis, resulting in a high rate of reoperation. Mechanical prostheses on the other hand are based on metallic, carbon, and polymeric components, and require continuous treatment with anticoagulant, which result in adverse reactions, e...
October 22, 2016: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/27756541/growth-and-maturation-of-heart-valves-leads-to-changes-in-endothelial-cell-distribution-impaired-function-decreased-metabolism-and-reduced-cell-proliferation
#6
Lindsey J Anstine, Chris Bobba, Samir Ghadiali, Joy Lincoln
Risk factors of heart valve disease are well defined and prolonged exposure throughout life leads to degeneration and dysfunction in up to 33% of the population. While aortic valve replacement remains the most common need for cardiovascular surgery particularly in those aged over 65, the underlying mechanisms of progressive deterioration are unknown. In other cardiovascular systems, a decline in endothelial cell integrity and function play a major role in promoting pathological changes, and while similar mechanisms have been speculated in the valves, studies to support this are lacking...
October 15, 2016: Journal of Molecular and Cellular Cardiology
https://www.readbyqxmd.com/read/27696730/the-future-of-heart-valve-replacement-recent-developments-and-translational-challenges-for-heart-valve-tissue-engineering
#7
Emanuela S Fioretta, Petra E Dijkman, Maximilian Y Emmert, Simon P Hoerstrup
Heart valve replacement is often the only solution for patients suffering from valvular heart disease. However, currently available valve replacements require either life-long anti-coagulation or are associated with valve degeneration and calcification. Moreover, they are suboptimal for young patients, because they do not adapt to the somatic growth. Tissue-engineering has been proposed as a promising approach to fulfill the urgent need for heart valve replacements with regenerative and growth capacity. This review will start with an overview on the currently available valve substitutes and the techniques for heart valve replacement...
September 30, 2016: Journal of Tissue Engineering and Regenerative Medicine
https://www.readbyqxmd.com/read/27692170/vitamin-d-regulates-the-production-of-vascular-endothelial-growth-factor-a-triggering-cause-in-the-pathogenesis-of-rheumatic-heart-disease
#8
Subendu Sarkar, Seema Chopra, Manoj Kumar Rohit, Dibyajyoti Banerjee, Anuradha Chakraborti
Rheumatic heart disease (RHD) remains a major cause of cardiac related mortality and morbidity in the developing countries due to poor diagnosis and lack of proper therapeutics. The definite reason of heart valve injury during RHD is poorly understood. Valvular endothelial cells play an important role in pathogenesis of different cardiovascular diseases. Besides, the regulation of vitamin D (calciferol) and VEGF (vascular endothelial growth factor) results in the functional changes in endothelial cells. However, the crosstalk between vitamin D and VEGF in the pathogenesis of RHD is not yet unfurled...
October 2016: Medical Hypotheses
https://www.readbyqxmd.com/read/27665220/surgical-reconstruction-of-semilunar-valves-in-the-growing-child-should-we-mimic-the-venous-valve-a-simulation-study
#9
Peter E Hammer, Erin G Roberts, Sitaram M Emani, Pedro J Del Nido
OBJECTIVES: Neither heart valve repair methods nor current prostheses can accommodate patient growth. Normal aortic and pulmonary valves have 3 leaflets, and the goal of valve repair and replacement is typically to restore normal 3-leaflet morphology. However, mammalian venous valves have bileaflet morphology and open and close effectively over a wide range of vessel sizes. We propose that they might serve as a model for pediatric heart valve reconstruction and replacement valve design...
August 31, 2016: Journal of Thoracic and Cardiovascular Surgery
https://www.readbyqxmd.com/read/27660586/metastatic-cardiac-angiosarcoma-in-a-26-year-old-male
#10
Elizabeth S Ellent, Ronald Chong-Yik, Abdul Mukhtadir Khan
BACKGROUND: Cardiac angiosarcomas are an extremely rare tumor with an incidence of only 0.056%. Diagnosing this rare tumor becomes even more difficult as the presentation of cardiac angiosarcomas varies based on anatomic location. Depending on the tumor's proximity to valves, symptoms may be more consistent with heart failure, while growth throughout the conduction system may produce arrhythmias. CASE REPORT: We present the case of a young male with a significant tumor burden of cardiac angiosarcoma in his lungs whose symptoms included pleuritic chest pain and hemoptysis...
2016: Ochsner Journal
https://www.readbyqxmd.com/read/27624834/fruit-shape-diversity-in-the-brassicaceae-is-generated-by-varying-patterns-of-anisotropy
#11
Tilly Eldridge, Łukasz Łangowski, Nicola Stacey, Friederike Jantzen, Laila Moubayidin, Adrien Sicard, Paul Southam, Richard Kennaway, Michael Lenhard, Enrico S Coen, Lars Østergaard
Fruits exhibit a vast array of different 3D shapes, from simple spheres and cylinders to more complex curved forms; however, the mechanism by which growth is oriented and coordinated to generate this diversity of forms is unclear. Here, we compare the growth patterns and orientations for two very different fruit shapes in the Brassicaceae: the heart-shaped Capsella rubella silicle and the near-cylindrical Arabidopsis thaliana silique. We show, through a combination of clonal and morphological analyses, that the different shapes involve different patterns of anisotropic growth during three phases...
September 15, 2016: Development
https://www.readbyqxmd.com/read/27541486/promotion-of-adhesion-and-proliferation-of-endothelial-progenitor-cells-on-decellularized-valves-by-covalent-incorporation-of-rgd-peptide-and-vegf
#12
Jianliang Zhou, Jingli Ding, Bin'en Nie, Shidong Hu, Zhigang Zhu, Jia Chen, Jianjun Xu, Jiawei Shi, Nianguo Dong
Tissue engineered heart valve is a promising alternative to current heart valve surgery, for its capability of growth, repair, and remodeling. However, extensive development is needed to ensure tissue compatibility, durability and antithrombotic potential. This study aims to investigate the biological effects of multi-signal composite material of polyethyl glycol-cross-linked decellularized valve on adhesion and proliferation of endothelial progenitor cells. Group A to E was decellularized valve leaflets, composite material of polyethyl glycol-cross-linked decellularized valves leaflets, vascular endothelial growth factor-composite materials, Arg-Gly-Asp peptide-composite materials and multi-signal modified materials of polyethyl glycol-cross-linked decellularized valve leaflets, respectively...
September 2016: Journal of Materials Science. Materials in Medicine
https://www.readbyqxmd.com/read/27534757/-enfants-porteurs-de-valvulopathies-post-rhumatismales-en-%C3%A2-histoire-naturelle-%C3%A2-suivi-de-5-ans-au-centre-cardiaque-de-l-h%C3%A3-pital-de-shisong-cameroun
#13
J C Tantchou Tchoumi, J C Ambassa, G Butera
The aim of the study was to investigate the pattern of valvular lesions, the mortality and the challenges in five years follow-up in children with post-rheumatic valvulopathies in natural history in St. Elizabeth Catholic General hospital Shisong, cardiac centre. This retrospective analysis included 270 patients aged between 5 and 16 years old suffering from post-rheumatic valvulopathies who consulted in the cardiac centre from July 2008 through July 2013. Postrheumatic valvulopathies were diagnosed according to the World heart federation criteria...
August 17, 2016: Bulletin de la Société de Pathologie Exotique
https://www.readbyqxmd.com/read/27508999/the-ross-procedure-in-adults-long-term-results-of-homografts-and-stentless-xenografts-for-pulmonary-valve-replacement
#14
Torsten Christ, Benjamin Claus, Nadine Woythal, Simon Dushe, Volkmar Falk, Herko Grubitzsch
Background The Ross procedure is an established method to treat aortic valve disease, offering excellent hemodynamic characteristics, growth potential, low risk of thromboembolism and no need for anticoagulation. Limitation of homograft quality and availability led to the use of different stentless xenografts. Long-term outcome and implications are yet to be addressed. Methods Forty five adult patients (mean age 38.8 ± 9.6 years) with aortic valve stenosis and/or insufficiency, who underwent the Ross procedure between 1995 and 2002 were identified for long-term evaluation...
August 10, 2016: Thoracic and Cardiovascular Surgeon
https://www.readbyqxmd.com/read/27476571/-acquired-left-ventricular-right-atrial-communication-due-to-infective-endocarditis-report-of-a-case
#15
Yoshie Sakasai, Akinobu Sasaki, Osamu Shigeta, Yasuaki Tsumagari, Hidekazu Tsuneoka, Masako Misaki, Noriyuki Takeyasu
A 77-year-old woman presented with a 3-week history of low grade fever, appetite loss and dizziness. An electrocardiogram showed complete heart block. Echocardiography demonstrated severe aortic valve stenosis and a mass of probable vegetation 2 cm in diameter on the atrioventricular septum in the right atrium (RA), but no obvious intra-cardiac fistula. There was no growth of organism in blood cul tures. In the 4th week after admission, a harsh and continuous cardiac murmur was detected for the 1st time. Portable echocardiography revealed disappearance of the mass in the RA, and showed an intra-cardiac shunt from the left ventricle( LV) to RA...
August 2016: Kyobu Geka. the Japanese Journal of Thoracic Surgery
https://www.readbyqxmd.com/read/27468412/denosumab-could-be-a-potential-inhibitor-of-valvular-interstitial-cells-calcification-in-vitro
#16
Daniel Alejandro Lerman, Sai Prasad, Nasri Alotti
OBJECTIVE: Denosumab is a fully human monoclonal antibody and novel antiresorptive agent that works by binding receptor activator of nuclear factor kappa-β ligand (RANKL) and inhibiting the signaling cascade that causes osteoclast maturation, activity, and survival. We aimed to elucidate the effect of Denosumab in the process of spontaneous and induced calcification in an in vitro porcine valvular interstitial cells (VICs) model. MATERIALS AND METHODS: VICs were extracted from fresh porcine hearts by serial collagenase digestion...
January 3, 2016: International Journal of Cardiovascular Research
https://www.readbyqxmd.com/read/27456367/late-outcomes-in-children-with-shone-s-complex-a-single-centre-20-year-experience
#17
George T Nicholson, Michael S Kelleman, Caridad M De la Uz, Ricardo H Pignatelli, Nancy A Ayres, Christopher J Petit
OBJECTIVE: Shone's syndrome is a complex consisting of mitral valve stenosis in addition to left ventricle outflow obstruction. There are a few studies evaluating the long-term outcomes in this population. We sought to determine the long-term outcomes in our paediatric population with Shone's syndrome and the factors associated with left heart growth. METHODS: All patients diagnosed with Shone's syndrome with biventricular circulation treated between 1978 and 2010 were reviewed...
July 26, 2016: Cardiology in the Young
https://www.readbyqxmd.com/read/27450399/cardiac-hypertrophy-an-introduction-to-molecular-and-cellular-basis
#18
Mostafa Samak, Javid Fatullayev, Anton Sabashnikov, Mohamed Zeriouh, Bastian Schmack, Mina Farag, Aron-Frederik Popov, Pascal M Dohmen, Yeong-Hoon Choi, Thorsten Wahlers, Alexander Weymann
Ventricular hypertrophy is an ominous escalation of hemodynamically stressful conditions such as hypertension and valve disease. The pathophysiology of hypertrophy is complex and multifactorial, as it touches on several cellular and molecular systems. Understanding the molecular background of cardiac hypertrophy is essential in order to protect the myocardium from pathological remodeling, or slow down the destined progression to heart failure and cardiomyopathy. In this review we highlight the most important molecular aspects of cardiac hypertrophic growth in light of the currently available published research data...
2016: Medical Science Monitor Basic Research
https://www.readbyqxmd.com/read/27426734/heterozygous-mutations-in-map3k7-encoding-tgf-%C3%AE-activated-kinase-1-cause-cardiospondylocarpofacial-syndrome
#19
Carine Le Goff, Curtis Rogers, Wilfried Le Goff, Graziella Pinto, Damien Bonnet, Maya Chrabieh, Olivier Alibeu, Patrick Nistchke, Arnold Munnich, Capucine Picard, Valérie Cormier-Daire
Cardiospondylocarpofacial (CSCF) syndrome is characterized by growth retardation, dysmorphic facial features, brachydactyly with carpal-tarsal fusion and extensive posterior cervical vertebral synostosis, cardiac septal defects with valve dysplasia, and deafness with inner ear malformations. Whole-exome sequencing identified heterozygous MAP3K7 mutations in six distinct CSCF-affected individuals from four families and ranging in age from 5 to 37 years. MAP3K7 encodes transforming growth factor β (TGF-β)-activated kinase 1 (TAK1), which is involved in the mitogen-activated protein kinase (MAPK)-p38 signaling pathway...
August 4, 2016: American Journal of Human Genetics
https://www.readbyqxmd.com/read/27423336/effect-of-aortic-pericardial-valve-choice-on-outcomes-and-left-ventricular-mass-regression-in-patients-with-left-ventricular-hypertrophy
#20
Fraser D Rubens, Yen-Yen Gee, Janet M C Ngu, Li Chen, Ian G Burwash
OBJECTIVES: We sought to assess the effect of 2 contemporary pericardial valves on left ventricular mass regression and clinical outcomes after aortic valve replacement (AVR) in patients with aortic stenosis (AS). METHODS: Patients were followed postoperatively in a dedicated valve clinic. A propensity score was derived for each patient and used to adjust all analyses. Longitudinal analysis was performed using a repeated measures growth curve model. Survival analysis was assessed with a Cox proportional hazards model...
June 18, 2016: Journal of Thoracic and Cardiovascular Surgery
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