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https://www.readbyqxmd.com/read/28070934/long-term-outcomes-after-mechanical-aortic-valve-replacement-with-aortic-root-enlargement-in-adolescents
#1
Zhiwei Xu, Qiuxia Shi, Ju Mei, Yan Tan
BACKGROUND: Deciding which prosthetic aortic valve to choose is difficult in adolescents who have not yet met their full growth potential. The aim of this study was to assess long-term outcomes following mechanical aortic valve replacement with aortic root enlargement in adolescents. METHODS: Between September 1997 and December 2006, 58 consecutive adolescents (49 male, 9 female, median age 15.5, range 13 to 17 years) underwent mechanical aortic valve replacement with aortic root enlargement...
January 10, 2017: Journal of Cardiac Surgery
https://www.readbyqxmd.com/read/28057868/glucocorticoid-receptor-alters-isovolumetric-contraction-and-restrains-cardiac-fibrosis
#2
Rachel Richardson, Emma Batchen, Adrian Thomson, Rowan Darroch, Xinlu Pan, Eva Rog-Zielinska, Wiktoria Wyrzykowska, Kathleen Scullion, Emad A S Al-Dujaili, Mary Diaz, Carmel Moran, Chris J Kenyon, Gillian A Gray, Karen Chapman
Corticosteroids directly affect the heart and vasculature and are implicated in the pathogenesis of heart failure. Attention has focussed upon the role of the mineralocorticoid receptor (MR) in mediating pro-fibrotic and other adverse effects of corticosteroids upon the heart. In contrast, the role of the glucocorticoid receptor (GR) in the heart and vasculature is less well understood. We addressed this in mice with cardiomyocyte and vascular smooth muscle deletion of GR (SMGRKO mice). Survival of SMGRKO mice to weaning was reduced compared with littermate controls...
January 5, 2017: Journal of Endocrinology
https://www.readbyqxmd.com/read/28042644/cardiovascular-comorbidities-in-acromegaly-an-update-on-their-diagnosis-and-management
#3
REVIEW
Ana M Ramos-Leví, Mónica Marazuela
Comorbidities related to the cardiovascular system are one of the most prevalent in patients with acromegaly, and contribute to an increased risk of morbidity and all-cause mortality. Specifically, hypertension, cardiomyopathy, heart valve disease, arrhythmias, atherosclerosis, coronary artery disease, and cardiac dysfunction may be frequent findings. Although the underlying physiopathology for each comorbidity may not be fully elucidated, uncontrolled growth hormone/insulin-like growth factor 1 excess, age, prolonged disease duration, and coexistence of other cardio-vascular risk factors are significant influencing variables...
January 2, 2017: Endocrine
https://www.readbyqxmd.com/read/28025719/cabergoline-in-acromegaly
#4
REVIEW
Emmanuelle Kuhn, Philippe Chanson
Acromegaly, a rare disease due to growth hormone (GH) hypersecretion by a pituitary adenoma, is associated with severe comorbidity and premature death if not adequately treated. The usual first-line treatment is surgery. Various drugs, including somatostatin receptor ligands, dopamine agonists and GH receptor antagonists, are now available for use if surgery fails to suppress GH/IGF-I hypersecretion. Cabergoline, now the preferred dopamine agonist for treating hyperprolactinemia, is also used off-label for treating acromegaly...
December 26, 2016: Pituitary
https://www.readbyqxmd.com/read/28005033/-infective-endocarditis-importance-of-molecular-biological-techniques-in-etiological-diagnosis
#5
E O Kotova, E A Domonova, Yu L Karaulova, A S Mil'to, A S Pisaryuk, O Yu Sil'veistrova, O Yu Shipulina, G A Shipulin, V S Moiseev
AIM: To investigate the specific features of conventional bacteriological methods and current molecular biological techniques for the etiological diagnosis of infective endocarditis (IE). SUBJECTS AND METHODS: Examinations were made in 53 patients treated at City Clinical Hospital Sixty-Four, Moscow Healthcare Department, in 2012-2015 who underwent simultaneous bacteriological and molecular biological (polymerase chain reaction (PCR) or PCR with further sequencing) examinations of blood or resected cardiac valve tissues...
2016: Terapevticheskiĭ Arkhiv
https://www.readbyqxmd.com/read/27995570/hydrodynamic-assessment-of-aortic-valves-prepared-from-porcine-small-intestinal-submucosa
#6
Sharan Ramaswamy, Makensley Lordeus, Omkar V Mankame, Lilliam Valdes-Cruz, Steven Bibevski, Sarah M Bell, Ivan Baez, Frank Scholl
Infants and children born with severe cardiac valve lesions have no effective long term treatment options since currently available tissue or mechanical prosthetic valves have sizing limitations and no avenue to accommodate the growth of the pediatric patient. Tissue engineered heart valves (TEHVs) which could provide for growth, self-repair, infection resistance, and long-term replacement could be an ideal solution. Porcine small intestinal submucosa (PSIS) has recently emerged as a potentially attractive bioscaffold for TEHVs...
December 19, 2016: Cardiovascular Engineering and Technology
https://www.readbyqxmd.com/read/27989051/pga-polyglycolic-acid-p4hb-poly-4-hydroxybutyrate-based-bioengineered-valves-in-the-rat-aortic-circulation
#7
Agnieszka A Książek, Katharyn J Mitchell, Nikola Cesarovic, Colin C Schwarzwald, Simon P Hoerstrup, Benedikt Weber
BACKGROUND: Bioengineered living autologous valves with remodeling and growth capacity represent a promising concept for future cardiac and venous valve repair. A meticulous understanding of the mechanisms involved in recellularization and remodeling is essential for the safe and efficient clinical translation of this technology. In this context, the first investigations of bioengineered vascular grafts in immune-incompetent or transgenic rodents represented an important step. However, the in-vivo assessment of bioengineered synthetic scaffold-based (biodegradable) valve replacements in rodent models has not been achieved to date...
May 2016: Journal of Heart Valve Disease
https://www.readbyqxmd.com/read/27852480/use-of-computed-tomography-to-guide-mitral-interventions
#8
REVIEW
Vladimir Jelnin, Chad Kliger, Fabio Zucchetta, Carlos E Ruiz
With increasing utilization of cardiac computed tomographic angiography (CTA) and widespread adoption of fusion imaging technology allowing the merger of pre-procedural CTA with fluoroscopy, the ability of CTA to guide structural heart interventions has evolved significantly. It has opened new possibilities in mitral valve (MV) interventions with improved pre-procedural planning and intra-procedural guidance. Given the lack of fluoroscopic landmarks of the mitral apparatus and continued growth of native MV device technologies, the value of CTA will continue to develop...
January 2016: Interventional cardiology clinics
https://www.readbyqxmd.com/read/27847254/vascular-calcification-in-ckd-mbd-roles-for-phosphate-fgf23-and-klotho
#9
REVIEW
Shunsuke Yamada, Cecilia M Giachelli
Vascular calcification (VC) is highly prevalent in aging, diabetes mellitus, and chronic kidney disease (CKD). VC is a strong predictor of cardiovascular morbidity and mortality in the CKD population. Complex pathological mechanisms are involved in the development of VC, including osteochondrogenic differentiation and apoptosis of vascular smooth muscle cells, instability and release of extracellular vesicles loaded calcium and phosphate, and elastin degradation. Elevated serum phosphate is a late manifestation of CKD, and has been shown to accelerate mineral deposition in both the vessel wall and heart valves...
November 12, 2016: Bone
https://www.readbyqxmd.com/read/27834758/current-status-of-tissue-engineering-heart-valve
#10
Toshiharu Shinoka, Hideki Miyachi
The development of surgically implantable heart valve prostheses has contributed to improved outcomes in patients with cardiovascular disease. However, there are drawbacks, such as risk of infection and lack of growth potential. Tissue-engineered heart valve (TEHV) holds great promise to address these drawbacks as the ideal TEHV is easily implanted, biocompatible, non-thrombogenic, durable, degradable, and ultimately remodels into native-like tissue. In general, three main components used in creating a tissue-engineered construct are (1) a scaffold material, (2) a cell type for seeding the scaffold, and (3) a subsequent remodeling process driven by cell accumulation and proliferation, and/or biochemical and mechanical signaling...
November 2016: World Journal for Pediatric & Congenital Heart Surgery
https://www.readbyqxmd.com/read/27789941/nanopatterned-acellular-valve-conduits-drive-the-commitment-of-blood-derived-multipotent-cells
#11
Rosa Di Liddo, Paola Aguiari, Silvia Barbon, Thomas Bertalot, Amit Mandoli, Alessia Tasso, Sandra Schrenk, Laura Iop, Alessandro Gandaglia, Pier Paolo Parnigotto, Maria Teresa Conconi, Gino Gerosa
Considerable progress has been made in recent years toward elucidating the correlation among nanoscale topography, mechanical properties, and biological behavior of cardiac valve substitutes. Porcine TriCol scaffolds are promising valve tissue engineering matrices with demonstrated self-repopulation potentiality. In order to define an in vitro model for investigating the influence of extracellular matrix signaling on the growth pattern of colonizing blood-derived cells, we cultured circulating multipotent cells (CMC) on acellular aortic (AVL) and pulmonary (PVL) valve conduits prepared with TriCol method and under no-flow condition...
2016: International Journal of Nanomedicine
https://www.readbyqxmd.com/read/27780149/nanofibrous-bioengineered-heart-valve-application-in-paediatric-medicine
#12
REVIEW
Mehrdad Namdari, Ali Eatemadi
Heart valves are currently under thorough investigation in tissue engineering (TE) research. Mechanical and biological heart valve prostheses which are recently used have several shortcomings. While allogenic and xenogenic biological prostheses are related to graft rejection, degeneration and thrombosis, resulting in a high rate of reoperation. Mechanical prostheses on the other hand are based on metallic, carbon, and polymeric components, and require continuous treatment with anticoagulant, which result in adverse reactions, e...
December 2016: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/27756541/growth-and-maturation-of-heart-valves-leads-to-changes-in-endothelial-cell-distribution-impaired-function-decreased-metabolism-and-reduced-cell-proliferation
#13
Lindsey J Anstine, Chris Bobba, Samir Ghadiali, Joy Lincoln
Risk factors of heart valve disease are well defined and prolonged exposure throughout life leads to degeneration and dysfunction in up to 33% of the population. While aortic valve replacement remains the most common need for cardiovascular surgery particularly in those aged over 65, the underlying mechanisms of progressive deterioration are unknown. In other cardiovascular systems, a decline in endothelial cell integrity and function play a major role in promoting pathological changes, and while similar mechanisms have been speculated in the valves, studies to support this are lacking...
November 2016: Journal of Molecular and Cellular Cardiology
https://www.readbyqxmd.com/read/27696730/the-future-of-heart-valve-replacement-recent-developments-and-translational-challenges-for-heart-valve-tissue-engineering
#14
Emanuela S Fioretta, Petra E Dijkman, Maximilian Y Emmert, Simon P Hoerstrup
Heart valve replacement is often the only solution for patients suffering from valvular heart disease. However, currently available valve replacements require either life-long anti-coagulation or are associated with valve degeneration and calcification. Moreover, they are suboptimal for young patients, because they do not adapt to the somatic growth. Tissue-engineering has been proposed as a promising approach to fulfill the urgent need for heart valve replacements with regenerative and growth capacity. This review will start with an overview on the currently available valve substitutes and the techniques for heart valve replacement...
September 30, 2016: Journal of Tissue Engineering and Regenerative Medicine
https://www.readbyqxmd.com/read/27692170/vitamin-d-regulates-the-production-of-vascular-endothelial-growth-factor-a-triggering-cause-in-the-pathogenesis-of-rheumatic-heart-disease
#15
Subendu Sarkar, Seema Chopra, Manoj Kumar Rohit, Dibyajyoti Banerjee, Anuradha Chakraborti
Rheumatic heart disease (RHD) remains a major cause of cardiac related mortality and morbidity in the developing countries due to poor diagnosis and lack of proper therapeutics. The definite reason of heart valve injury during RHD is poorly understood. Valvular endothelial cells play an important role in pathogenesis of different cardiovascular diseases. Besides, the regulation of vitamin D (calciferol) and VEGF (vascular endothelial growth factor) results in the functional changes in endothelial cells. However, the crosstalk between vitamin D and VEGF in the pathogenesis of RHD is not yet unfurled...
October 2016: Medical Hypotheses
https://www.readbyqxmd.com/read/27665220/surgical-reconstruction-of-semilunar-valves-in-the-growing-child-should-we-mimic-the-venous-valve-a-simulation-study
#16
Peter E Hammer, Erin G Roberts, Sitaram M Emani, Pedro J Del Nido
OBJECTIVES: Neither heart valve repair methods nor current prostheses can accommodate patient growth. Normal aortic and pulmonary valves have 3 leaflets, and the goal of valve repair and replacement is typically to restore normal 3-leaflet morphology. However, mammalian venous valves have bileaflet morphology and open and close effectively over a wide range of vessel sizes. We propose that they might serve as a model for pediatric heart valve reconstruction and replacement valve design...
August 31, 2016: Journal of Thoracic and Cardiovascular Surgery
https://www.readbyqxmd.com/read/27660586/metastatic-cardiac-angiosarcoma-in-a-26-year-old-male
#17
Elizabeth S Ellent, Ronald Chong-Yik, Abdul Mukhtadir Khan
BACKGROUND: Cardiac angiosarcomas are an extremely rare tumor with an incidence of only 0.056%. Diagnosing this rare tumor becomes even more difficult as the presentation of cardiac angiosarcomas varies based on anatomic location. Depending on the tumor's proximity to valves, symptoms may be more consistent with heart failure, while growth throughout the conduction system may produce arrhythmias. CASE REPORT: We present the case of a young male with a significant tumor burden of cardiac angiosarcoma in his lungs whose symptoms included pleuritic chest pain and hemoptysis...
2016: Ochsner Journal
https://www.readbyqxmd.com/read/27624834/fruit-shape-diversity-in-the-brassicaceae-is-generated-by-varying-patterns-of-anisotropy
#18
Tilly Eldridge, Łukasz Łangowski, Nicola Stacey, Friederike Jantzen, Laila Moubayidin, Adrien Sicard, Paul Southam, Richard Kennaway, Michael Lenhard, Enrico S Coen, Lars Østergaard
Fruits exhibit a vast array of different 3D shapes, from simple spheres and cylinders to more complex curved forms; however, the mechanism by which growth is oriented and coordinated to generate this diversity of forms is unclear. Here, we compare the growth patterns and orientations for two very different fruit shapes in the Brassicaceae: the heart-shaped Capsella rubella silicle and the near-cylindrical Arabidopsis thaliana silique. We show, through a combination of clonal and morphological analyses, that the different shapes involve different patterns of anisotropic growth during three phases...
September 15, 2016: Development
https://www.readbyqxmd.com/read/27541486/promotion-of-adhesion-and-proliferation-of-endothelial-progenitor-cells-on-decellularized-valves-by-covalent-incorporation-of-rgd-peptide-and-vegf
#19
Jianliang Zhou, Jingli Ding, Bin'en Nie, Shidong Hu, Zhigang Zhu, Jia Chen, Jianjun Xu, Jiawei Shi, Nianguo Dong
Tissue engineered heart valve is a promising alternative to current heart valve surgery, for its capability of growth, repair, and remodeling. However, extensive development is needed to ensure tissue compatibility, durability and antithrombotic potential. This study aims to investigate the biological effects of multi-signal composite material of polyethyl glycol-cross-linked decellularized valve on adhesion and proliferation of endothelial progenitor cells. Group A to E was decellularized valve leaflets, composite material of polyethyl glycol-cross-linked decellularized valves leaflets, vascular endothelial growth factor-composite materials, Arg-Gly-Asp peptide-composite materials and multi-signal modified materials of polyethyl glycol-cross-linked decellularized valve leaflets, respectively...
September 2016: Journal of Materials Science. Materials in Medicine
https://www.readbyqxmd.com/read/27534757/children-with-post-rheumatic-valvulopathies-in-natural-history-five-years-follow-up-in-the-cardiac-centre-st-elizabeth-catholic-general-hospital-shisong-cameroon
#20
J C Tantchou Tchoumi, J C Ambassa, G Butera
The aim of the study was to investigate the pattern of valvular lesions, the mortality and the challenges in five years follow-up in children with post-rheumatic valvulopathies in natural history in St. Elizabeth Catholic General hospital Shisong, cardiac centre. This retrospective analysis included 270 patients aged between 5 and 16 years old suffering from post-rheumatic valvulopathies who consulted in the cardiac centre from July 2008 through July 2013. Postrheumatic valvulopathies were diagnosed according to the World heart federation criteria...
December 2016: Bulletin de la Société de Pathologie Exotique
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