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https://www.readbyqxmd.com/read/28820030/epidemiology-of-cardiovascular-disease-in-the-united-states-implications-for-the-perfusion-profession-a-2017-update
#1
Joseph J Sistino, David C Fitzgerald
INTRODUCTION: By analyzing epidemiological trends in cardiovascular disease (CVD), key stakeholders can make informed decisions on the future of disease burden and treatment. Accordingly, the cardiovascular perfusion community would benefit from data that would help predict future professional resource utilization. METHODS: In 2003, the changes in the number of hospital discharges for CVD from 1990 to 2000 were published, based on data from the National Center for Health Statistics (NCHS)...
September 2017: Perfusion
https://www.readbyqxmd.com/read/28791264/prediction-of-pregnancy-complication-occurrence-using-fetal-cardiac-output-assessments-made-by-ultrasonography-at-20-to-24-weeks-of-gestation
#2
Ji Yeon Lee, Young Li Kim, Ji Eun Jeong, Jun Woo Ahn
OBJECTIVE: To evaluate the importance of assessment of fetal cardiac output (CO) for the prediction of complications of pregnancy. METHODS: We evaluated 65 fetuses and all of them had a fetal cardiac scan at 20 to 24 weeks of pregnancy. To measure CO, diameters (d) of the left right ventricle outflow tract were measured just above the valves. Each left CO (LCO) and right CO (RCO) was derived using the following equation: CO = velocity time integral × π × d(2)/4 × heart rate...
July 2017: Obstetrics & Gynecology Science
https://www.readbyqxmd.com/read/28782585/weaving-for-heart-valve-tissue-engineering
#3
REVIEW
Albert Liberski, Nadia Ayad, Dorota Wojciechowska, Radoslaw Kot, Duy M P Vo, Dilibaier Aibibu, Gerald Hoffmann, Chokri Cherif, Katharina Grobelny-Mayer, Marek Snycerski, Helmut Goldmann
Weaving is a resourceful technology which offers a large selection of solutions that are readily adaptable for tissue engineering (TE) of artificial heart valves (HV). The different ways that the yarns are interlaced in this technique could be used to produce complex architectures, such as the three-layer architecture of the leaflets. Once the assembly is complete, growth of cells in the scaffold would occur in the orientation of the yarn, enabling the deposition of extra cellular matrixes proteins in an oriented manner...
August 3, 2017: Biotechnology Advances
https://www.readbyqxmd.com/read/28748765/biomarkers-in-aortic-valve-stenosis-and-their-clinical-significance-in-transcatheter-aortic-valve-implantation
#4
Konstantinos Toutouzas, Konstantinos Stathogiannis, George Latsios, Andreas Synetos, Maria Drakopoulou, Vicky Penesopoulou, Archontoula Michelongona, Eleftherios Tsiamis, Dimitris Tousoulis
Aortic valve stenosis is one of the most common valvular heart disorders and the prevalence will rise as the population ages. Once symptomatic, patients with aortic valve stenosis tend to fare worse with high mortality rates. Aortic valve replacement is indicated in these patients and besides the standard surgical replacement; a less invasive approach, transcatheter aortic valve implantation, has gained momentum and has showed promising and solid results in patients with high surgical risk. An important aspect of evaluating patients with aortic valve stenosis is the ability to choose the best possible candidate for the procedure...
July 27, 2017: Current Medicinal Chemistry
https://www.readbyqxmd.com/read/28745279/paediatric-nanofibrous-bioprosthetic-heart-valve
#5
REVIEW
Mehrdad Namdari, Babak Negahdari, Ali Eatemadi
The search for an optimal aortic valve implant with durability, calcification resistance, excellent haemodynamic parameters and ability to withstand mechanical loading is yet to be met. Thus, there has been struggled to fabricate bio-prosthetics heart valve using bioengineering. The consequential product must be resilient with suitable mechanical features, biocompatible and possess the capacity to grow. Defective heart valves replacement by surgery is now common, this improves the value and survival of life for a lot of patients...
August 2017: IET Nanobiotechnology
https://www.readbyqxmd.com/read/28718893/association-between-maternal-vascular-murmur-and-the-small-for-gestational-age-fetus-with-abnormal-umbilical-artery-doppler-flow
#6
Diana Riknagel, Richard Farlie, Morten Hedegaard, Peter Humaidan, Johannes J Struijk
OBJECTIVE: To investigate the association between maternal vascular murmurs (MVMs) and fetal growth restriction (defined as small-for-gestational-age [SGA] fetus) and abnormal Doppler pulsatility index (PI) of the uterine and/or umbilical arteries. METHODS: A cross-sectional study of women aged 18 years or older with a singleton pregnancy at 28-34 weeks was conducted at Regional Hospital Viborg, Denmark, between May 1 and August 1, 2013. Ultrasound fetal biometry was performed and the Doppler PI of the umbilical and uterine arteries was determined...
July 18, 2017: International Journal of Gynaecology and Obstetrics
https://www.readbyqxmd.com/read/28716564/endothelial-to-mesenchymal-transition-in-the-cardiovascular-system
#7
REVIEW
Hui Gong, Xing Lyu, Qiong Wang, Min Hu, Xiangyu Zhang
Endothelial to mesenchymal transition (EndMT) is a special type of epithelial to mesenchymal transition. It is a process that is characterized by the loss of features of endothelial cells and acquisition of specific markers of mesenchymal cells. A variety of stimuli, such as inflammation, growth factors, and hypoxia, regulate EndMT through various signaling pathways and intracellular transcription factors. It has been demonstrated that epigenetic modifications are also involved in this process. Recent studies have identified the essential role of EndMT in the cardiovascular system...
September 1, 2017: Life Sciences
https://www.readbyqxmd.com/read/28714932/thrombospondins-a-role-in-cardiovascular-disease
#8
REVIEW
Dimitry A Chistiakov, Alexandra A Melnichenko, Veronika A Myasoedova, Andrey V Grechko, Alexander N Orekhov
Thrombospondins (TSPs) represent extracellular matrix (ECM) proteins belonging to the TSP family that comprises five members. All TSPs have a complex multidomain structure that permits the interaction with various partners including other ECM proteins, cytokines, receptors, growth factors, etc. Among TSPs, TSP1, TSP2, and TSP4 are the most studied and functionally tested. TSP1 possesses anti-angiogenic activity and is able to activate transforming growth factor (TGF)-β, a potent profibrotic and anti-inflammatory factor...
July 17, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28676926/the-infant-with-aortic-arch-hypoplasia-and-small-left-heart-structures-echocardiographic-indices-of-mitral-and-aortic-hypoplasia-predicting-successful-biventricular-repair
#9
Jennifer M Plymale, Peter C Frommelt, Melodee Nugent, Pippa Simpson, James S Tweddell, Amanda J Shillingford
In infants with aortic arch hypoplasia and small left-sided cardiac structures, successful biventricular repair is dependent on the adequacy of the left-sided structures. Defining accurate thresholds of echocardiographic indices predictive of successful biventricular repair is paramount to achieving optimal outcomes. We sought to identify pre-operative echocardiographic indices of left heart size that predict intervention-free survival in infants with small left heart structures undergoing primary aortic arch repair to establish biventricular circulation (BVC)...
August 2017: Pediatric Cardiology
https://www.readbyqxmd.com/read/28674029/atla-mediates-extracellular-dna-release-that-contributes-to-streptococcus-mutans-biofilm-formation-in-an-experimental-infective-endocarditis-rat-model
#10
Chiau-Jing Jung, Ron-Bin Hsu, Chia-Tung Shun, Chih-Chieh Hsu, Jean-San Chia
Host factors, like platelets, have been shown to enhance biofilm formation of oral commensal streptococci, inducing infective endocarditis (IE), but how bacterial components contribute to biofilm formation in vivo is still not clear. We previously demonstrated that an isogenic mutant strain of Streptococcus mutans deficient in autolysin AtlA (ΔatlA) showed reduced ability to cause vegetation in a rat model of bacterial endocarditis. However, the role of AtlA in bacterial biofilm formation is unclear. Herein, confocal laser scanning microscopy analysis showed the extracellular DNA (eDNA) embedded inside S...
July 3, 2017: Infection and Immunity
https://www.readbyqxmd.com/read/28644382/metal-ion-loaded-nanofibre-matrices-for-calcification-inhibition-in-polyurethane-implants
#11
Charanpreet Singh, Xungai Wang
Pathologic calcification leads to structural deterioration of implant materials via stiffening, stress cracking, and other structural disintegration mechanisms, and the effect can be critical for implants intended for long-term or permanent implantation. This study demonstrates the potential of using specific metal ions (MI)s for inhibiting pathological calcification in polyurethane (PU) implants. The hypothesis of using MIs as anti-calcification agents was based on the natural calcium-antagonist role of Mg(2+) ions in human body, and the anti-calcification effect of Fe(3+) ions in bio-prosthetic heart valves has previously been confirmed...
June 23, 2017: Journal of Functional Biomaterials
https://www.readbyqxmd.com/read/28633268/surgical-interventional-hybrid-concept-in-a-newborn-with-borderline-left-heart
#12
Stefan Rupp, Josef Thul, Kerstin Gummel, Markus Khalil, Hakan Akintuerk, Dietmar Schranz
Through a series of complex surgical and interventional procedures including downsizing of an unrestricted atrial septal defect, aortic arch reconstruction, pulmonary artery banding, reversed Potts shunt, and Melody valve in a mitral position, biventricular conversion was successfully achieved in a patient with a distinct borderline left ventricle. By use of these interventional steps, flow-mediated and load-mediated growth of a small left ventricle was observed, highlighting the plasticity of hearts in growing children...
July 2017: Annals of Thoracic Surgery
https://www.readbyqxmd.com/read/28620766/phenotype-transformation-of-aortic-valve-interstitial-cells-due-to-applied-shear-stresses-within-a-microfluidic-chip
#13
Xinmei Wang, Joohyung Lee, Mir Ali, Jungkyu Kim, Carla M R Lacerda
Despite valvular heart diseases constituting a significant medical problem, the acquisition of information describing their pathophysiology remains difficult. Due to valvular size, role and location within the body, there is a need for in vitro systems that can recapitulate disease onset and progression. This study combines the development of an in vitro model and its application in the mechanical stimulation of valvular cell transformation. Specifically, porcine aortic valvular interstitial cells (PAVIC) were cultured on polydimethylsiloxane microfluidic devices with or without exposure to shear stresses...
June 15, 2017: Annals of Biomedical Engineering
https://www.readbyqxmd.com/read/28612558/-significance-and-expressions-of-mmp-1-timp-1-and-tgf-%C3%AE-1-in-valve-tissue-of-rheumatic-heart-disease
#14
Yi Yu, Zeng-Qi Li, Kun Chen, Ping Zhan, Jian Liao, Qin-Yun Ruan
OBJECTIVES: To explore expressions of matrix metalloproteinase-1 (MMP-1), tissue inhibitor of metalloproteinases-1 (TIMP-1) and transforming growth factor-β1 (TGF-β1) in valve tissue of rheumatic heart disease (RHD), and to analyzed their roles in RHD. METHODS: The expressions of MMP-1, TIMP-1 and TGF-β1 proteins and mRNAs were tested by Western blot and RT-PCR methods in valve tissues in participants with (experimental group, n=30) and without RHD (control group, n=15)...
January 2017: Sichuan da Xue Xue Bao. Yi Xue Ban, Journal of Sichuan University. Medical Science Edition
https://www.readbyqxmd.com/read/28605496/validation-of-microbiological-testing-in-cardiovascular-tissue-banks-results-of-a-quality-round-trial
#15
Theo M M H de By, Carl McDonald, Susanne Süßner, Jill Davies, Wee Ling Heng, Ramadan Jashari, Ad J J C Bogers, Pieter Petit
OBJECTIVES: Surgeons needing human cardiovascular tissue for implantation in their patients are confronted with cardiovascular tissue banks that use different methods to identify and decontaminate micro-organisms. To elucidate these differences, we compared the quality of processing methods in 20 tissue banks and 1 reference laboratory. We did this to validate the results for accepting or rejecting tissue. We included the decontamination methods used and the influence of antibiotic cocktails and residues with results and controls...
June 12, 2017: European Journal of Cardio-thoracic Surgery
https://www.readbyqxmd.com/read/28594399/essential-but-partially-redundant-roles-for-pou4f1-brn-3a-and-pou4f2-brn-3b-transcription-factors-in-the-developing-heart
#16
Lauren J Maskell, Kashif Qamar, Aram A Babakr, Thomas A Hawkins, Richard J Heads, Vishwanie S Budhram-Mahadeo
Congenital heart defects contribute to embryonic or neonatal lethality but due to the complexity of cardiac development, the molecular changes associated with such defects are not fully understood. Here, we report that transcription factors (TFs) Brn-3a (POU4F1) and Brn-3b (POU4F2) are important for normal cardiac development. Brn-3a directly represses Brn-3b promoter in cardiomyocytes and consequently Brn-3a knockout (KO) mutant hearts express increased Brn-3b mRNA during mid-gestation, which is linked to hyperplastic growth associated with elevated cyclin D1, a known Brn-3b target gene...
June 8, 2017: Cell Death & Disease
https://www.readbyqxmd.com/read/28584461/infective-endocarditis-due-to-abiotrophia-defectiva-and-its-feared-complications-in-an-immunocompetent-person-rare-but-real
#17
Mohan Rudrappa, Laxmi Kokatnur
Abiotrophia defectiva is nutritional deficient streptococci that cannot be cultured on routine culture medias. Even though fastidious in growth requirement, it is a virulent bacterium preferentially affecting endovascular structures and is implicated in many culture-negative endocarditis cases. Unlike other organisms, it is known for heart valve destruction leading to heart failure and excessive embolization rates. It's inherent resistance to routinely used antibiotics also contributed to increased mortality and morbidity in affected individuals and warrants timely diagnosis and prompt treatment...
April 2017: Journal of Global Infectious Diseases
https://www.readbyqxmd.com/read/28567021/assessment-of-fetal-development-using-cardiac-valve-intervals
#18
Faezeh Marzbanrad, Ahsan H Khandoker, Yoshitaka Kimura, Marimuthu Palaniswami, Gari D Clifford
An automated method to assess the fetal physiological development is introduced which uses the component intervals between fetal cardiac valve timings and the Q-wave of fetal electrocardiogram (fECG). These intervals were estimated automatically from one-dimensional Doppler Ultrasound and noninvasive fECG. We hypothesize that the fetal growth can be estimated by the cardiac valve intervals. This hypothesis was evaluated by modeling the fetal development using the cardiac intervals and validating against the gold standard gestational age identified by Crown-Rump Length (CRL)...
2017: Frontiers in Physiology
https://www.readbyqxmd.com/read/28520542/hybrid-palliation-for-interrupted-aortic-arch-with-small-aortic-valve
#19
Yoshimasa Uno, Ayumu Masuoka, Kentarou Hotoda, Toshiyuki Katogi, Takaaki Suzuki
OBJECTIVES: Open heart surgery for interrupted aortic arch in the neonatal period is still a high-risk procedure related in part to patient factors such as low birth weight, other morphologic anomalies, and, especially, small aortic valve size. Recently, we performed hybrid palliation with bilateral pulmonary artery banding and ductal stenting as the first-stage palliation for such cases. In this study, the outcomes of this procedure were examined. METHODS: Six cases of interrupted aortic arch with a small aortic valve underwent the hybrid procedure in the neonatal period in our institute from 2010 to 2015 (mean age: 6...
May 2017: World Journal for Pediatric & Congenital Heart Surgery
https://www.readbyqxmd.com/read/28520540/virtual-surgery-for-conduit-reconstruction-of-the-right-ventricular-outflow-tract
#20
Chin Siang Ong, Yue-Hin Loke, Justin Opfermann, Laura Olivieri, Luca Vricella, Axel Krieger, Narutoshi Hibino
PURPOSE: Virtual surgery involves the planning and simulation of surgical reconstruction using three-dimensional (3D) modeling based upon individual patient data, augmented by simulation of planned surgical alterations including implantation of devices or grafts. Here we describe a case in which virtual cardiac surgery aided us in determining the optimal conduit size to use for the reconstruction of the right ventricular outflow tract. DESCRIPTION: The patient is a young adolescent male with a history of tetralogy of Fallot with pulmonary atresia, requiring right ventricle-to-pulmonary artery (RV-PA) conduit replacement...
May 2017: World Journal for Pediatric & Congenital Heart Surgery
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