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Heart valve diameter changes

Ricarda Hinzpeter, Matthias Eberhard, Philipp Burghard, Felix C Tanner, Maurizio Taramasso, Robert Manka, Gudrun Feuchtner, Francesco Maisano, Hatem Alkadhi
AIMS: The aim of this study is to present a contrast media (CM) protocol for the dynamic visualisation of the tricuspid valve (TV) and tricuspid annulus (TA) with CT. METHODS AND RESULTS: Fifteen patients with no cardiac abnormalities (controls), 15 patients with functional tricuspid regurgitation (FTR) <3+, and 13 patients with FTR ≥3+ underwent a dedicated cardiac CT protocol. Using advanced visualisation, segmentation and analysis software, the annular area, entire annular circumference, its three parts, and annular diameters were measured by two independent, blinded readers...
February 3, 2017: EuroIntervention
Marcello Chinali, Claudia Esposito, Giorgia Grutter, Roberta Iacobelli, Alessandra Toscano, Maria Grazia D'Asaro, Alessia Del Pasqua, Gianluca Brancaccio, Francesco Parisi, Fabrizio Drago, Gabriele Rinelli
BACKGROUND: Transplanted heart dysfunction is a serious life-threatening condition in pediatric transplant recipients. Several studies have focused on echocardiographic detection of early signs of cardiac dysfunction in this population. We evaluated advanced echocardiographic indices of cardiac function in a large sample of children and young adults with heart transplants with apparently normal cardiac function. METHODS: The study included 60 patients with normal ejection fraction with transplantation performed at pediatric age between 1986 and 2014 and 60 healthy control subjects...
December 1, 2016: Journal of Heart and Lung Transplantation
Agnieszka A Książek, Katharyn J Mitchell, Nikola Cesarovic, Colin C Schwarzwald, Simon P Hoerstrup, Benedikt Weber
BACKGROUND: Bioengineered living autologous valves with remodeling and growth capacity represent a promising concept for future cardiac and venous valve repair. A meticulous understanding of the mechanisms involved in recellularization and remodeling is essential for the safe and efficient clinical translation of this technology. In this context, the first investigations of bioengineered vascular grafts in immune-incompetent or transgenic rodents represented an important step. However, the in-vivo assessment of bioengineered synthetic scaffold-based (biodegradable) valve replacements in rodent models has not been achieved to date...
May 2016: Journal of Heart Valve Disease
Takao Konishi, Naohiro Funayama, Tadashi Yamamoto, Daisuke Hotta, Kenjiro Kikuchi, Katsumi Ohori, Hiroshi Nishihara, Shinya Tanaka
BACKGROUND: A small mitral valve aneurysm (MVA) presenting as severe mitral regurgitation (MR) is uncommon. CASE PRESENTATION: A 47-year-old man with a history of hypertension complained of exertional chest discomfort. A transthoracic echocardiogram (TTE) revealed the presence of MR and prolapse of the posterior leaflet. A 6-mm in diameter MVA, not clearly visualized by TTE, was detected on the posterior leaflet on a three-dimensional (3D) transesophageal echocardiography (TEE)...
November 22, 2016: BMC Cardiovascular Disorders
Robert W Loar, Athar M Qureshi, Christina Y Miyake, Santiago O Valdes, Jeffrey J Kim, Caridad M De la Uz
BACKGROUND: Percutaneous pulmonary valve implantation (PPVI) is utilized for dysfunctional right ventricular outflow tracts (RVOT) to relieve obstruction, regurgitation, and RV dysfunction. PPVI has not been reported to induce arrhythmias. This study is the first to report the incidence of ventricular tachycardia (VT) after PPVI. METHODS: This was a retrospective study of all patients who had PPVI at a single institution. All patients were admitted after PPVI for overnight telemetry monitoring...
December 2016: Journal of Interventional Cardiology
G Taçoy, H D Başer, A Çengel, K Başer, Ö Kuş, A F Tuncel, A Bolayır, H Paşaoğlu, B Boyaci, R Yalçın
Objective: Right heart function is a major determinant of clinical outcome in patients with elevated pulmonary artery pressure due to pulmonary venous hypertension (PVH) and pulmonary arterial hypertension (PAH). Asymmetric dimethylarginine (ADMA) is an endogenous inhibitor of nitric oxide synthase. In our study, we aimed to evaluate if different type of pulmonary hypertension (PH) cause the same effect on right heart functions and serum asymmetric dimethylarginine (ADMA) levels in female patients...
March 14, 2016: West Indian Medical Journal
Augusto D'Onofrio, Laura Besola, Giulio Rizzoli, Eleonora Bizzotto, Erica Manzan, Chiara Tessari, Roberto Bianco, Giuseppe Tarantini, Luigi P Badano, Massimo Napodano, Chiara Fraccaro, Demetrio Pittarello, Gino Gerosa
BACKGROUND: This single-center retrospective study assessed the variation of left ventricular ejection fraction (LVEF) after transapical transcatheter aortic valve implantation and its effect on survival. We also evaluated the effect of sheath diameter on LVEF. METHODS: We analyzed data of all consecutive patients who underwent transapical transcatheter aortic valve implantation with the Sapien (Edwards Lifesciences, Irvine, CA) device (and its evolutions) between 2009 and 2015...
February 2017: Annals of Thoracic Surgery
Pei Ma, Shi Gu, Ganga H Karunamuni, Michael W Jenkins, Michiko Watanabe, Andrew M Rollins
Cardiac neural crest cell (CNCC) ablation creates congenital heart defects (CHDs) that resemble those observed in many syndromes with craniofacial and cardiac consequences. The loss of CNCCs causes a variety of great vessel defects, including persistent truncus arteriosus and double-outlet right ventricle. However, because of the lack of quantitative volumetric measurements, less severe defects, such as great vessel size changes and valve defects, have not been assessed. Also poorly understood is the role of abnormal cardiac function in the progression of CNCC-related CHDs...
November 1, 2016: American Journal of Physiology. Heart and Circulatory Physiology
J-M Bourget, R Zegdi, J Lin, P Wawryko, Y Merhi, C Convelbo, J Mao, Y Fu, T Xu, N O Merkel, L Wang, L Germain, Z Zhang, R Guidoin
INTRODUCTION: Transcathether heart valve replacement has gained considerable acceptance during the last decades. It is now part of the armamentarium for aortic valve replacement. The procedure proved to be highly efficient. However the issues of the blood compatibility and tissue durability were not raised and the adverse events were probably under-reported, according to observations of thrombosis after deployment. MATERIAL AND METHOD: Bovine pericardium leaflets were sewn inside a 26mm diameter stainless steel stent to manufacture these valves (one control and two experimental)...
July 13, 2016: Morphologie: Bulletin de L'Association des Anatomistes
Grayson A Doss, Christoph Mans, Rebecca L Stepien
Alpha2-agonist anesthetic combinations are often used in rodent anesthesia but no information about their effects on cardiac function in chinchillas exists. The purpose of this study was to utilize echocardiography to evaluate the cardiovascular effects of dexmedetomidine-ketamine anesthesia in chinchillas. Echocardiographic examinations were performed in eight adult chinchillas under manual restraint and following dexmedetomidine (0.015 mg/kg) and ketamine (4 mg/kg) administration. Dexmedetomidine-ketamine anesthesia resulted in a significantly decreased heart rate, fractional shortening, cardiac output, and flow velocity across the aortic and pulmonic valves, and significantly increased left ventricular internal diameter in systole...
February 2017: Laboratory Animals
Shu-Ling Diao, Hui-Pu Xu, Bei Zhang, Bao-Xin Ma, Xian-Liang Liu
BACKGROUND To examine changes of mRNA and protein expressions of MMP-2, Bcl-2, and BAX in atrial fibrillation (AF) patients, and investigate the correlations among these 3 biomarkers. MATERIAL AND METHODS Rheumatic heart disease patients (n=158) undergoing cardiac surgical procedures for mitral valve repair or replacement were included as the AF group (n=123), containing paroxysmal AF (n=42), persistent AF (n=36), and permanent AF (n=45). Rheumatic heart disease patients with sinus rhythm (SR) (n=35) were enrolled as the SR group (control group)...
May 4, 2016: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
Sandy Engelhardt, Ivo Wolf, Sameer Al-Maisary, Harald Schmidt, Hans-Peter Meinzer, Matthias Karck, Raffaele De Simone
PURPOSE: Analysis of mitral valve morphology during reconstruction is routinely based on visual assessment and subjective, poorly reproducible measurements. We prove the feasibility of a new intraoperative system for quantitative mitral valve analysis. DESCRIPTION: The proposed computer-based assistance system enables accurate intraoperative localization of anatomic landmarks on the mitral valve apparatus using optical tracking technology. Measurement and visualization strategies were specifically developed and tailored for mitral valve operations...
May 2016: Annals of Thoracic Surgery
Antonio H Frangieh, Christiane Gruner, Fran Mikulicic, Adrian Attinger-Toller, Felix C Tanner, Maurizio Taramasso, Roberto Corti, Jürg Grünenfelder, Thomas F Lüsche, Frank Ruschitzka, Dominique Bettex, Francesco Maisano, Oliver Gaemperli
AIMS: Tricuspid regurgitation (TR) severity and right ventricular (RV) dysfunction have been identified as significant predictors of outcome after mitral valve surgery. The aim of the present study was to investigate the impact of percutaneous mitral valve repair (PMVR) with the MitraClip system on functional TR severity and RV function. METHODS AND RESULTS: Among 119 consecutive patients with severe mitral regurgitation who underwent PMVR, 67 had complete baseline and follow-up transthoracic echocardiography after 3-12 months (6...
April 8, 2016: EuroIntervention
Tatsuya Ogawa, Masahiko Onoe, Souji Moriwaki, Keisuke Shioji, Ayumi Iwamuro, Takashi Uegaito, Mitsuo Matsuda
OBJECTIVE: Few studies have reported on aortic valve replacement (AVR) in patients aged >80 years who have small aortic annuli. Various surgical techniques have been proposed for treating such patients. We investigated AVR using small-diameter mechanical valves, in patients aged >80 years, to determine its effectiveness. METHODS: Eighteen consecutive patients (15 women; 3 men) aged >80 (mean: 83.3 ± 2.7) years underwent surgical AVR with a 17-mm prosthesis...
July 2016: Journal of Thoracic and Cardiovascular Surgery
Francesca N Delling, Jian Rong, Martin G Larson, Birgitta Lehman, Deborah Fuller, Ewa Osypiuk, Plamen Stantchev, Brianne Hackman, Warren J Manning, Emelia J Benjamin, Robert A Levine, Ramachandran S Vasan
BACKGROUND: Longitudinal studies of mitral valve prolapse (MVP) progression among unselected individuals in the community, including those with nondiagnostic MVP morphologies (NDMs), are lacking. METHODS AND RESULTS: We measured longitudinal changes in annular diameter, leaflet displacement, thickness, anterior/posterior leaflet projections onto the annulus, coaptation height, and mitral regurgitation jet height in 261 Framingham Offspring participants at examination 5 who had available follow-up imaging 3 to 16 years later...
April 26, 2016: Circulation
Richard Fojt, Zuzana Moťovská, Petr Budera, Marek Malý, Zbyněk Straka
BACKGROUND: Significant aortic stenosis (AS) is frequently associated with mitral regurgitation (MR) of varying degrees. We sought to assess the change in MR grade after the aortic valve procedure, to find predictors of MR improvement and finally to determine the prognostic impact of persistent MR. METHODS: We retrospectively analyzed a group of 101 AS patients who underwent aortic valve replacement (AVR) or transcatheter aortic valve implantation (TAVI) at our institution between January 2007 and March 2014 and who presented with MR grade 2 or higher on preoperative echocardiogram - 35 patients underwent an isolated AVR, 18 underwent TAVI, and the rest underwent a combined procedure, which included coronary artery bypass grafting...
June 2016: Journal of Cardiology
Mehdi Jahandardoost, Guy Fradet, Hadi Mohammadi
To date, to the best of the authors' knowledge, in almost all of the studies performed around the hemodynamics of bileaflet mechanical heart valves, a heart rate of 70-72 beats/min has been considered. In fact, the heart rate of ~72 beats/min does not represent the entire normal physiological conditions under which the aortic or prosthetic valves function. The heart rates of 120 or 50 beats/min may lead to hemodynamic complications, such as plaque formation and/or thromboembolism in patients. In this study, the hemodynamic performance of the bileaflet mechanical heart valves in a wide range of normal and physiological heart rates, that is, 60-150 beats/min, was studied in the opening phase...
March 2016: Proceedings of the Institution of Mechanical Engineers. Part H, Journal of Engineering in Medicine
Gil Talmon, Daniel L Fink, Yoseph Horowitz, Dan Miron
BACKGROUND: Viruses are the most prevalent ausative agents of myocarditis in young children. Studies have shown acute myocarditis in post mortem examinations during viral disease outbreaks. The aims of this study are to assess the prevalence of and risk factors for subclinical acute myocarditis in young children hospitalized with an acute viral disease. OBJECTIVES: Evaluation of the prevalence of asymptomatic myocarditis or decrease in heart functions during viral infection...
October 2015: Harefuah
Xu-jing Xie, Sheng-jie Liao, Yue-heng Wu, Cong Lu, Ping Zhu, Hong-wen Fei, Xue-jun Xiao, Huan-lei Huang
OBJECTIVES: Outcomes of tricuspid valve replacement are poor, partly due to right heart remodelling. The research on its underlying mechanisms is hampered by a lack of animal models of tricuspid regurgitation (TR). Our objective was to create a reproducible and clinically compatible TR animal model to study right heart remodelling caused by TR. METHODS: Fourteen juvenile male Beagle dogs were divided randomly into an intervention group (n = 11) and a sham-operated control group (n = 3)...
February 2016: Interactive Cardiovascular and Thoracic Surgery
Soo Youn Lee, Chi Young Shim, Geu-Ru Hong, Jiwon Seo, Iksung Cho, In Jeong Cho, Hyuk-Jae Chang, Jong-Won Ha, Namsik Chung
A bicuspid aortic valve (BAV) is often associated with dilation or aneurysm of the ascending aorta (AA) despite of absence of significant valve dysfunction. Bicuspid aortopathy and consequent aortic stiffness may adversely affect left ventricular (LV) diastolic function. This study aimed to investigate the impact of global and regional aortic mechanical function on LV diastolic function in subjects with BAV. Fifty-six subjects with BAV (45 men, mean age 52 ± 13 years) without significant valve dysfunction and 56 age- and gender-matched controls with tricuspid aortic valve were studied...
November 15, 2015: American Journal of Cardiology
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