keyword
MENU ▼
Read by QxMD icon Read
search

Peptic ulcer

keyword
https://www.readbyqxmd.com/read/28746317/acute-upper-gastrointestinal-bleeding-in-a-tertiary-care-centre-of-nepal
#1
M S Paudel, S Kc, A K Mandal, N S Poudyal, R Shrestha, B N Paudel, S Chaudhary
INTRODUCTION: AUGIB is characterized by hematemesis or melena or both. Peptic ulcers and variceal bleed account for majority of cases. Use of proton pump inhibitors in current era is associated with a gradual reduction in burden of peptic ulcer disease. We conducted this study to look into the cause of AUGIB in our community. METHODS: We studied 100 patients in one year period who presented to us with hematemesis or melena. The study was conducted in department of Gastroenterology, Bir hospital, Kathmandu...
April 2017: JNMA; Journal of the Nepal Medical Association
https://www.readbyqxmd.com/read/28738919/laparoscopic-approach-to-perforated-peptic-ulcers-trends-toward-quicker-recovery
#2
Salim Hosein, Jeffrey C Lawrence, George M Fuhrman, William S Richardson
No abstract text is available yet for this article.
July 1, 2017: American Surgeon
https://www.readbyqxmd.com/read/28735835/effect-of-scheduled-second-look-endoscopy-on-peptic-ulcer-bleeding-a-prospective-randomized-multicenter-trial
#3
Soo Jung Park, Hyojin Park, Yong Chan Lee, Chang Hwan Choi, Tae Joo Jeon, Jun Chul Park, Jie-Hyun Kim, Young Hoon Youn, Yu Jin Kim, Jae Hak Kim, Kwang Jae Lee, Sun Gyo Lim, Hyung Gil Kim, Byoung Wook Bang
BACKGROUND AND AIM: This study aimed to investigate the effectiveness of scheduled second-look EGD with endoscopic hemostasis on peptic ulcer rebleeding and sought to identify the risk factors related to the need for second-look EGD. METHODS: We prospectively randomized patients who had endoscopically confirmed bleeding peptic ulcer with stigmata of active bleeding, visible vessel, or adherent clot into 2 groups between August 2010 and January 2013. Hemoclip application or thermal coagulation, and/or epinephrine injection were allowed for initial endoscopic therapy...
July 20, 2017: Gastrointestinal Endoscopy
https://www.readbyqxmd.com/read/28733944/the-gastric-and-intestinal-microbiome-role-of-proton-pump-inhibitors
#4
REVIEW
Artem Minalyan, Lilit Gabrielyan, David Scott, Jonathan Jacobs, Joseph R Pisegna
PURPOSE OF REVIEW: The discovery of Helicobacter pylori and other organisms colonizing the stomach and the intestines has shed some light on the importance of microbiome in maintaining overall health and developing pathological conditions when alterations in biodiversity are present. The gastric acidity plays a crucial role in filtering out bacteria and preventing development of enteric infections. In this article, we discuss the physiology of gastric acid secretion and bacterial contribution to the composition of gastric and intestinal barriers and review the current literature on the role of proton pump inhibitors (PPIs) in the microbial biodiversity of the gastrointestinal tract...
August 2017: Current Gastroenterology Reports
https://www.readbyqxmd.com/read/28729760/structural-insight-into-the-binding-of-c60-derivatives-with-enoyl-pyruvate-transferase-from-helicobacter-pylori
#5
Mohammad Teimouri, Muhammad Junaid, Abbas Khan, Houjin Zhang
Helicobacter pylori (H. pylori) is a human pathogen associated with acute gastritis and peptic ulcer. The MurA enzyme is an important drug target for the identification of ligands with improved efficacy and acceptable pharmaco-kinetic properties. We developed a homology model of H. Pylori MurA followed by refinement and molecular dynamics (MD) simulations. A total of 16 C60-derivatives were docked and its docking score were compared. Some of the known inhibitors were also similarly characterized and compared...
2017: Bioinformation
https://www.readbyqxmd.com/read/28728310/the-effect-of-h2-receptor-antagonist-in-acid-inhibition-and-its-clinical-efficacy
#6
REVIEW
Young Kwang Shim, Nayoung Kim
The first histamine H2 receptor antagonists (H2RAs) were developed in the early 1970s. They played a dominant role in treating peptic ulcer disease and gastroesophageal reflux disease (GERD). H2RAs block the production of acid by H(+), K(+)-ATPase at the parietal cells and produce gastric luminal anacidity for varying periods. H2RAs are highly selective, and they do not affect H1 receptors. Moreover, they are not anticholinergic agents. Sequential development of H2RAs, proton pump inhibitors (PPIs), and discovery of Helicobacter pylori infection changed the paradigm of peptic ulcer disease with marked decrease of morbidity and mortality...
July 25, 2017: Korean Journal of Gastroenterology, Taehan Sohwagi Hakhoe Chi
https://www.readbyqxmd.com/read/28726018/association-of-vagotomy-and-decreased-risk-of-subsequent-ischemic-stroke-in-complicated-peptic-ulcer-patients-an-asian-population-study
#7
Chu-Wen Fang, Chun-Hung Tseng, Shih-Chi Wu, William Tzu-Liang Chen, Chih-Hsin Muo
OBJECTIVES: The primary management of peptic ulcers is medical treatment. Persistent exacerbation of a peptic ulcer may lead to complications (perforation and/or bleeding). There has been a trend toward the use of a less invasive surgical simple suture, simple local suture or non-operative (endoscopic/angiography) hemostasis rather than acid-reducing vagotomy (i.e., vagus nerve severance) for treating complicated peptic ulcers. Other studies have shown the relationship between high vagus nerve activity and survival in cancer patients via reduced levels of inflammation, indicating the essential role of the vagus nerve...
July 19, 2017: World Journal of Surgery
https://www.readbyqxmd.com/read/28722083/-a-perception-of-the-development-trend-of-radiological-t-staging-in-gastric-cancer-through-uicc-ajcc-8-th-edition
#8
Lei Tang
More and more emphases were put on pre-therapy staging following the promotion of multidisciplinary team(MDT) collaboration and individualized medicine in gastric cancer. However, the accuracy of traditional radiology staging system which applies mechanically pathological staging is not satisfactory during clinical practice, therefore, the objectivity of treatment decisions is affected. Under such conditions, the newly introduced staging system from Union for International Cancer Control/American Joint Committee on Cancer(UICC/AJCC)(8(th) edition) divided out an independent cTNM system for the first time, and summarized the application range, operation specification and staging criteria...
July 25, 2017: Zhonghua Wei Chang Wai Ke za Zhi, Chinese Journal of Gastrointestinal Surgery
https://www.readbyqxmd.com/read/28721219/two-rare-manifestations-of-primary-hyperparathyroidism-paralysis-and-peptic-ulcer-bleeding
#9
Maryam Heidarpour, Mehdi Karami, Pegah Hedayat, Ashraf Aminorroaya
Primary hyperparathyroidism revealed by thoracic spine brown tumor and peptic ulcer bleeding is rare. We presented a case of 33-year-old male patient who was admitted with paraplegia. Thoracic spine magnetic resonance imaging (MRI) showed extradural lesion at T4 level. He underwent surgical decompression in T4. According to histopathologic finding and elevated serum parathormone (PTH) and hypercalcemia (total serum calcium 12.1 mg/dL), the diagnosis of brown tumor was down. Ultrasonography of his neck showed a well-defined lesion of 26 × 14 × 6 mm...
2017: Endocrinology, Diabetes & Metabolism Case Reports
https://www.readbyqxmd.com/read/28714072/survival-of-patients-with-cirrhosis-and-acute-peptic-ulcer-bleeding-compared-with-variceal-bleeding-using-current-first-line-therapies
#10
Alba Ardevol, Gemma Ibañez-Sanz, Joaquim Profitos, Carles Aracil, Josep M Castellvi, Edilmar Alvarado, Alba Cachero, Diana Horta, Josep Miñana, Bárbara Gomez-Pastrana, Oana Pavel, Eva Dueñas, Meritxell Casas, Montserrat Planella, Jose Castellote J, Candid Villanueva
The presence of cirrhosis increases the mortality of patients with peptic ulcer bleeding (PUB). Both acute variceal bleeding (AVB) and PUB are associated with substantial mortality in cirrhosis. This multicenter cohort study was performed to assess whether the mortality of cirrhotic patients with PUB is different from that of those with AVB. Patients with cirrhosis and acute gastrointestinal bleeding were consecutively included and treated with somatostatin and PPI infusion from admission and with antibiotic prophylaxis...
July 17, 2017: Hepatology: Official Journal of the American Association for the Study of Liver Diseases
https://www.readbyqxmd.com/read/28711557/postprandial-hypoglycemia-complication-of-peptic-ulcer-surgery
#11
Adnan Haider, James K Burks, H I Cheema, Angel Tejada
OBJECTIVE: Billroth II procedures (gastrojejunostomy with vagotomy) are seldom performed now, but were popular before the advent of histamine 2 (H2) receptor blockers and proton pump inhibitors (PPIs). Such procedures can be a cause of late postprandial hypoglycemia. METHOD: Formal evaluation, discussion of postprandial hypoglycemia. RESULTS: We present a case of an 85-year-old man who presented to the Endocrinology clinic with a complaint of "fainting spells following large meals...
July 12, 2017: American Journal of Medicine
https://www.readbyqxmd.com/read/28706400/hybrid-therapy-versus-sequential-therapy-for-eradication-of-helicobacter-pylori-a-randomized-controlled-trial
#12
Sahoo Ashokkumar, Sonia Agrawal, Jharna Mandal, Sathasivam Sureshkumar, Gubbi Shamanna Sreenath, Vikram Kate
OBJECTIVE: To compare the sequential therapy (ST) with the hybrid therapy (HT) for the eradication of Helicobacter pylori. MATERIALS AND METHODS: Patients with peptic ulcer disease and gastritis found to be H. pylori positive were randomized to HT group who received omeprazole (20 mg bid) and amoxicillin (1 g bid) for 7 days followed by omeprazole (20 mg bid), amoxicillin (1 g bid), clarithromycin (500 mg bid), and metronidazole (400 mg tid) for the next 7 days and ST group who received omeprazole and amoxicillin for 5 days followed by omeprazole, clarithromycin, and metronidazole for the next 5 days...
April 2017: Journal of Pharmacology & Pharmacotherapeutics
https://www.readbyqxmd.com/read/28704230/effect-of-esophageal-cancer-surgeon-volume-on-management-and-mortality-from-emergency-upper-gastrointestinal-conditions-population-based-cohort-study
#13
Sheraz R Markar, Hugh Mackenzie, Alan Askari, Omar Faiz, George B Hanna
OBJECTIVE: To study the influence of esophageal cancer surgeon volume upon mortality from upper gastrointestinal emergencies. BACKGROUND: Volume-outcome relationships led to the centralization of esophageal cancer surgery. METHODS: Hospital Episode Statistics data were used to identify patients admitted to hospitals within England (1997-2012). The influence of esophageal high-volume (HV) cancer surgeon status (≥5 resections per year) upon 30-day and 90-day mortality from esophageal perforation (EP), paraesophageal hernia causing obstruction or gangrene (PEH) and perforated peptic ulcer (PPU) was analyzed, independent of HV esophageal cancer center status and patient and disease-specific confounding factors...
July 12, 2017: Annals of Surgery
https://www.readbyqxmd.com/read/28702966/possible-role-of-helicobacter-pylori-in-diseases-of-dermatological-interest
#14
C Guarneri, J Lotti, M Fioranelli, M G Roccia, T Lotti, F Guarneri
Helicobacter pylori is a gram-negative, flagellate, microaerophilic bacterium identified for the first time about 30 years ago, as a pathogenic factor of gastritis and peptic ulcer. Soon after, it was linked to several gastrointestinal and extra-gastrointestinal diseases (hematological, cardiovascular, neurological, pulmonary and ocular diseases, obesity, diabetes mellitus, growth retardation and extragastric MALT lymphoma). Association and possible cause-effect correlation with H. pylori infection were suggested in diseases of dermatological interest such as chronic urticaria, rosacea, Henoch-Schoenleins purpura, idiopathic thrombocytopenic purpura, cutaneous and oral lichen planus, atopic dermatitis, recurrent aphthous stomatitis, systemic sclerosis, psoriasis, Sjögrens syndrome, Behçet's disease, pruritus, alopecia areata, primary cutaneous marginal zone B-cell lymphomas, vitiligo, chronic prurigo, multiformis, prurigo nodularis, leukocytoclastic vasculitis, prurigo pigmentosa, eczema nummulare, primary cutaneous MALT-type lymphoma, sublamina densa-type linear IgA bullous dermatosis, Sweet's syndrome, cutaneous T-cell pseudolymphoma and pemphigus vulgaris...
July 13, 2017: Journal of Biological Regulators and Homeostatic Agents
https://www.readbyqxmd.com/read/28701282/risk-factors-for-myocardial-dysfunction-after-traumatic-brain-injury-a-one-year-follow-up-study
#15
Kang Lu, Cheng-Loong Liang, Ping-Chia Li, Po-Chou Liliang, Chih-Yuan Huang, Yi-Che Lee, Kuo-Wei Wang, San-Nan Yang, Yuan-Ting Sun, Hao-Kuang Wang
INTRODUCTION: Traumatic brain injury has been associated with an increased risk of myocardial dysfunction. Common abnormalities accompanying this pathology include electrocardiographic abnormalities, elevated creatine kinase levels, arrhythmias, and pathologic changes of the myocardium. The aim of this study was to determine if TBI patients have a higher risk of myocardial dysfunction than the general population and to identify the risk factors of myocardial dysfunction in TBI patients...
July 8, 2017: Injury
https://www.readbyqxmd.com/read/28699830/cag-pathogenicity-island-dependent-up-regulation-of-matrix-metalloproteinase-7-in-infected-patients-with-helicobacter-pylori
#16
Marzieh Sadeghiani, Nader Bagheri, Heshmat Shahi, Somayeh Reiisi, Ghorbanali Rahimian, Reza Rashidi, Majid Mahsa, Mohammedhadi Shafigh, Elaheh Salimi, Mahmoud Rafieian-Kopaei, Morteza Hashemzadeh-Chaleshtori, Hedayatollah Shirzad
Helicobacter pylori (H. pylori) infection has been involved in the pathogenesis of most important gastroduodenal diseases. Matrix metalloproteinases (MMPs) are a family of secreted, zinc-dependent enzymes collectively capable of degradation of extracellular matrix (ECM) and key player in various inflammatory diseases. Therefore, we examined MMP-7 mRNA levels in the gastric mucosa of patients with H. pylori infection and evaluated the effects of virulence factors, such as vacA (vacuolating cytotoxin A) and cagA (cytotoxin-associated gene) in H...
July 12, 2017: Journal of Immunoassay & Immunochemistry
https://www.readbyqxmd.com/read/28697633/zinc-l-carnosine-suppresses-inflammatory-responses-in-lipopolysaccharide-induced-raw-264-7-murine-macrophages-cell-line-via-activation-of-nrf2-ho-1-signaling-pathway
#17
Theng Choon Ooi, Kok Meng Chan, Razinah Sharif
CONTEXT: Zinc L-carnosine (ZnC) is a chelate of Zn and L-carnosine and is used clinically in the treatment of peptic ulcer. OBJECTIVE: In this study, we aim to investigate the involvement of heme oxygenase-1 (HO-1) in the anti-inflammatory effects of ZnC in lipopolysaccharide (LPS)-induced RAW 264.7 murine macrophages. MATERIALS AND METHODS: We used immunoblotting analysis to evaluate the involvement of HO-1 in the anti-inflammatory effects of ZnC and the signaling pathway involved was measured using Dual luciferase reporter assay...
July 11, 2017: Immunopharmacology and Immunotoxicology
https://www.readbyqxmd.com/read/28697254/association-between-alendronate-use-and-hip-fracture-risk-in-older-patients-using-oral-prednisolone
#18
Kristian F Axelsson, Anna G Nilsson, Hans Wedel, Dan Lundh, Mattias Lorentzon
Importance: Oral glucocorticoid treatment increases fracture risk, and evidence is lacking regarding the efficacy of alendronate to protect against hip fracture in older patients using glucocorticoids. Objective: To investigate whether alendronate treatment in older patients using oral prednisolone is associated with decreased hip fracture risk and adverse effects. Design, Setting, and Participants: Retrospective cohort study using a national database (N = 433 195) of patients aged 65 years or older undergoing a health evaluation (baseline) at Swedish health care facilities; 1802 patients who were prescribed alendronate after at least 3 months of oral prednisolone treatment (≥5 mg/d) were identified...
July 11, 2017: JAMA: the Journal of the American Medical Association
https://www.readbyqxmd.com/read/28694576/zollinger-ellison-syndrome-in-a-12-year-old-child
#19
Abir Lal Nath, Nandita A Saxena, Bharati K Kulkarni, Shyam S Borwankar, Hemant N Lahoti, Sanjay N Oak
The syndrome described by Zollinger and Ellison in 1955 is a rare clinical entity which is even rarer in children. This report describes a 12-year-old boy who presented with refractory peptic ulcer disease which was finally diagnosed to be due to a gastrinoma and was successfully treated.
July 2017: Journal of Indian Association of Pediatric Surgeons
https://www.readbyqxmd.com/read/28693066/-fifth-chinese-national-consensus-report-on-the-management-of-helicobacter-pylori-infection
#20
G Liu, J Xie, Z R Lu, L Y Cheng, Y Zeng, J B Zhou, Y J Chen, N H Wang, Yiqi Du, Nonghua Lyu
The fifth national consensus conference on the management of Helicobacter pylori (H.pylori) infection organized by Chinese Medical Association, Chinese Society of Gastroenterology, H. pylori and Peptic Ulcer Study Group was held at Hangzhou, Zhejiang Province on December 15-16, 2016.More than 80 members of the study group and experts in the field of H. pylori research and gastroenterology attended the meeting.Consensus preparatory group was established to draft the related statements.The quality of evidence and strength of recommendation were evaluated by GRADE system...
July 1, 2017: Zhonghua Nei Ke za Zhi [Chinese Journal of Internal Medicine]
keyword
keyword
1485
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"