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https://www.readbyqxmd.com/read/27834758/current-status-of-tissue-engineering-heart-valve
#1
Toshiharu Shinoka, Hideki Miyachi
The development of surgically implantable heart valve prostheses has contributed to improved outcomes in patients with cardiovascular disease. However, there are drawbacks, such as risk of infection and lack of growth potential. Tissue-engineered heart valve (TEHV) holds great promise to address these drawbacks as the ideal TEHV is easily implanted, biocompatible, non-thrombogenic, durable, degradable, and ultimately remodels into native-like tissue. In general, three main components used in creating a tissue-engineered construct are (1) a scaffold material, (2) a cell type for seeding the scaffold, and (3) a subsequent remodeling process driven by cell accumulation and proliferation, and/or biochemical and mechanical signaling...
November 2016: World Journal for Pediatric & Congenital Heart Surgery
https://www.readbyqxmd.com/read/27780764/biodegradable-and-biomimetic-elastomeric-scaffolds-for-tissue-engineered-heart-valves
#2
REVIEW
Yingfei Xue, Vinayak Sant, Julie Phillippi, Shilpa Sant
Valvular heart diseases are the third leading cause of cardiovascular disease, resulting in more than 25,000 deaths annually in the United States. Heart valve tissue engineering (HVTE) has emerged as a putative treatment strategy such that the designed construct would ideally withstand native dynamic mechanical environment, guide regeneration of the diseased tissue and more importantly, have the ability to grow with the patient. These desired functions could be achieved by biomimetic design of tissue-engineered constructs that recapitulate in vivo heart valve microenvironment with biomimetic architecture, optimal mechanical properties and possess suitable biodegradability and biocompatibility...
October 22, 2016: Acta Biomaterialia
https://www.readbyqxmd.com/read/27703574/aortic-annular-enlargement-during-aortic-valve-replacement
#3
Selman Dumani, Ermal Likaj, Laureta Dibra, Stavri Llazo, Ali Refatllari
In the surgery of aortic valve replacement is always attempted, as much as possible, to implant the larger prosthesis with the mains goals to enhance the potential benefits, to minimise transvalvular gradient, decrease left ventricular size and avoid the phenomenon of patient-prosthesis mismatch. Implantation of an ideal prosthesis often it is not possible, due to a small aortic annulus. A variety of aortic annulus enlargement techniques is reported to avoid patient-prosthesis mismatch. We present the case that has submitted four three times open heart surgery...
September 15, 2016: Open Access Macedonian Journal of Medical Sciences
https://www.readbyqxmd.com/read/27570204/planar-biaxial-testing-of-heart-valve-cusp-replacement-biomaterials-experiments-theory-and-material-constants
#4
Michel R Labrosse, Reza Jafar, Janet Ngu, Munir Boodhwani
OBJECTIVES: Aortic valve (AV) repair has become an attractive option to correct aortic insufficiency. Yet, cusp reconstruction with various cusp replacement materials has been associated with greater long-term repair failures, and it is still unknown how such materials mechanically compare with native leaflets. We used planar biaxial testing to characterize six clinically relevant cusp replacement materials, along with native porcine AV leaflets, to ascertain which materials would be best suited for valve repair...
November 2016: Acta Biomaterialia
https://www.readbyqxmd.com/read/27498079/synchronous-ventricular-pacing-with-direct-capture-of-the-atrioventricular-conduction-system-functional-anatomy-terminology-and-challenges
#5
Siva K Mulpuru, Yong-Mei Cha, Samuel J Asirvatham
Right ventricular apical pacing is associated with an increased incidence of heart failure, atrial fibrillation, and overall mortality. As a result, pacing the ventricles in a manner that closely mimics normal AV conduction with an intact His-Purkinje system has been explored. Recently, the sustainable benefits of selective His-bundle stimulation have been demonstrated and proposed as the preferred method of ventricular stimulation for appropriate patients. Ideally, conduction system pacing should be selective without myocardial capture, overcome distal bundle branch block when present, and not compromise tricuspid valve function...
August 3, 2016: Heart Rhythm: the Official Journal of the Heart Rhythm Society
https://www.readbyqxmd.com/read/27491910/aortic-valve-sparing-in-different-aortic%C3%A2-valve-and-aortic-root-conditions
#6
REVIEW
Tirone E David
The development of aortic valve-sparing operations (reimplantation of the aortic valve and remodeling of the aortic root) expanded the surgical armamentarium for treating patients with aortic root dilation caused by a variety of disorders. Young adults with aortic root aneurysms associated with genetic syndromes are ideal candidates for reimplantation of the aortic valve, and the long-term results have been excellent. Incompetent bicuspid aortic valves with dilated aortic annuli are also satisfactorily treated with the same type of operation...
August 9, 2016: Journal of the American College of Cardiology
https://www.readbyqxmd.com/read/27443841/pulse-duplicator-hydrodynamic-testing-of-bioengineered-biological-heart-valves
#7
Eric E Buse, Stephen L Hilbert, Richard A Hopkins, Gabriel L Converse
There are many heart valve replacements currently available on the market; however, these devices are not ideal for pediatric patients with congenital heart valve defects. Decellularized valve substitutes offer potential for improved clinical outcomes and require pre-clinical testing guidelines and testing systems suitable for non-crosslinked, biological heart valves. The objective of this study was to assess the hydrodynamic performance of intact, bioengineered pulmonary valves using a custom pulse duplicator capable of testing intact biological valved conduits...
December 2016: Cardiovascular Engineering and Technology
https://www.readbyqxmd.com/read/27439413/current-management-of-ebstein-s-anomaly-in-the-adult
#8
REVIEW
Lucy M Safi, Richard R Liberthson, Ami Bhatt
Ebstein's anomaly is a congenital malformation of the tricuspid valve and the right heart with a spectrum of clinical and morphologic presentations. Minor anomalies of the tricuspid valve may not be recognized until adulthood whereas major anomalies leading to heart failure and cyanosis require surgical intervention earlier in life. Echocardiography is the imaging modality of choice for both diagnosis and management of patients with Ebstein's anomaly. Surgical correction includes tricuspid valve repair or replacement and associated findings such as interatrial communications and arrhythmias should be addressed at the time of surgery...
September 2016: Current Treatment Options in Cardiovascular Medicine
https://www.readbyqxmd.com/read/27437653/development-and-validation-of-a-risk-prediction-model-for-in-hospital-mortality-after-transcatheter-aortic-valve-replacement
#9
Fred H Edwards, David J Cohen, Sean M O'Brien, Eric D Peterson, Michael J Mack, David M Shahian, Frederick L Grover, E Murat Tuzcu, Vinod H Thourani, John Carroll, J Matthew Brennan, Ralph G Brindis, John Rumsfeld, David R Holmes
IMPORTANCE: Patient selection for transcatheter aortic valve replacement (TAVR) should include assessment of the risks of TAVR compared with surgical aortic valve replacement (SAVR). Existing SAVR risk models accurately predict the risks for the population undergoing SAVR, but comparable models to predict risk for patients undergoing TAVR are currently not available and should be derived from a population that underwent TAVR. OBJECTIVE: To use a national population of patients undergoing TAVR to develop a statistical model that will predict in-hospital mortality after TAVR...
April 1, 2016: JAMA Cardiology
https://www.readbyqxmd.com/read/27422199/effects-of-combined-cryopreservation-and-decellularization-on-the-biomechanical-structural-and-biochemical-properties-of-porcine-pulmonary-heart-valves
#10
Karolina Theodoridis, Janina Müller, Robert Ramm, Katja Findeisen, Birgit Andrée, Sotirios Korossis, Axel Haverich, Andres Hilfiker
UNLABELLED: Non-fixed, decellularized allogeneic heart valve scaffolds seem to be the best choice for heart valve replacement, their availability, however, is quite limited. Cryopreservation could prolong their shelf-life, allowing for their ideal match to a recipient. In this study, porcine pulmonary valves were decellularized using detergents, either prior or after cryopreservation, and analyzed. Mechanical integrity was analyzed by uniaxial tensile testing, histoarchitecture by histological staining, and composition by DNA, collagen (hydroxyproline) and GAG (chondroitin sulfate) quantification...
October 1, 2016: Acta Biomaterialia
https://www.readbyqxmd.com/read/27384867/successful-orthotopic-heart-transplantation-using-a-donor-heart-with-alcapa
#11
J D Simmonds, M Mustafa, D P Fajardo Jaramillo, H R Bellsham-Revell, J Marek, M Burch, V T Tsang, N Muthialu
With the imbalance between donation rates and potential recipients growing, transplant programs are increasingly using non-ideal organs from so-called marginal donors. This is the first reported case of the intentional use of a donor heart with ALCAPA. The recipient was aged one yr with restrictive cardiomyopathy who had been supported with BiVAD for over six months. Function of the donor left ventricle was shown to be well preserved, with no obvious signs of ischemia, except for a fibrotic layer on the anterolateral papillary muscle of the mitral valve...
September 2016: Pediatric Transplantation
https://www.readbyqxmd.com/read/27352237/timing-of-vitamin-k-antagonist-re-initiation-following-intracranial-hemorrhage-in-mechanical-heart-valves-systematic-review-and-meta-analysis
#12
Fahad AlKherayf, Yan Xu, Esteban Gandara, Harrison Westwick, Ioana Doina Moldovan, Philip S Wells
BACKGROUND: While evidence supports resumption of vitamin K antagonists (VKAs) among mechanical heart valve (MHV) patients presenting with anticoagulant-associated intracranial hemorrhage (ICH), ideal timing of resumption is uncertain. OBJECTIVE: To determine the optimal timing of VKA re-initiation and its associated clinical outcomes. METHODS: We performed a systematic review and a meta-analysis of studies published from January 1950 to August 2015...
August 2016: Thrombosis Research
https://www.readbyqxmd.com/read/27150672/heart-valves-from-polyester-fibers-vs-biological-tissue-comparative-study-in-vitro
#13
Atieh Yousefi, Antoine Vaesken, Amna Amri, Lakshmi Prasad Dasi, Frederic Heim
Transcatheter aortic valve implantation (TAVI) has become a popular alternative technique to surgical valve replacement for critical patients. Biological valve tissue has been used in TAVI procedures for over a decade, with over 100,000 implantations to date. However, with only 6 years follow up, little is known about the long-term durability of biological tissue. Moreover, the high cost of tissue harvesting and chemical treatment procedures favor the development of alternative synthetic valve leaflet materials...
May 5, 2016: Annals of Biomedical Engineering
https://www.readbyqxmd.com/read/27149367/cardiothoracic-applications-of-3-dimensional-printing
#14
Andreas A Giannopoulos, Michael L Steigner, Elizabeth George, Maria Barile, Andetta R Hunsaker, Frank J Rybicki, Dimitris Mitsouras
Medical 3-dimensional (3D) printing is emerging as a clinically relevant imaging tool in directing preoperative and intraoperative planning in many surgical specialties and will therefore likely lead to interdisciplinary collaboration between engineers, radiologists, and surgeons. Data from standard imaging modalities such as computed tomography, magnetic resonance imaging, echocardiography, and rotational angiography can be used to fabricate life-sized models of human anatomy and pathology, as well as patient-specific implants and surgical guides...
September 2016: Journal of Thoracic Imaging
https://www.readbyqxmd.com/read/27117348/towards-3d-in-vitro-models-for-the-study-of-cardiovascular-tissues-and-disease
#15
REVIEW
Alan J Ryan, Claire M Brougham, Carolina D Garciarena, Steven W Kerrigan, Fergal J O'Brien
The field of tissue engineering is developing biomimetic biomaterial scaffolds that are showing increasing therapeutic potential for the repair of cardiovascular tissues. However, a major opportunity exists to use them as 3D in vitro models for the study of cardiovascular tissues and disease in addition to drug development and testing. These in vitro models can span the gap between 2D culture and in vivo testing, thus reducing the cost, time, and ethical burden of current approaches. Here, we outline the progress to date and the requirements for the development of ideal in vitro 3D models for blood vessels, heart valves, and myocardial tissue...
September 2016: Drug Discovery Today
https://www.readbyqxmd.com/read/27012453/mitral-valve-repair-using-robotic-technology-safe-effective-and-durable
#16
EDITORIAL
Rakesh M Suri, Joseph A Dearani, Tomislav Mihaljevic, W Randolph Chitwood, Douglas A Murphy, Alfredo Trento, Hoda Javadikasgari, Harold M Burkhart, Wiley L Nifong, Richard C Daly, A Marc Gillinov
No abstract text is available yet for this article.
June 2016: Journal of Thoracic and Cardiovascular Surgery
https://www.readbyqxmd.com/read/26993479/flexible-band-versus-rigid-ring-annuloplasty-for-functional-tricuspid-regurgitation-two-different-patterns-of-right-heart-reverse-remodelling
#17
Giuseppe Gatti, Luca Dell'Angela, Marco Morosin, Luca Maschietto, Bruno Pinamonti, Bernardo Benussi, Gabriella Forti, Gian Luigi Nicolosi, Gianfranco Sinagra, Aniello Pappalardo
OBJECTIVES: Annuloplasty bands and rings are widely used to treat functional tricuspid regurgitation (TR). However, the question as to which is the ideal annuloplasty device remains open. Early and late outcomes of tricuspid valve annuloplasty with flexible band (B-TVA) or rigid ring (R-TVA) are compared in the present study. METHODS: Between 1999 and 2014, 462 consecutive patients (mean age, 69.2 ± 9.5 years) with grade ≥1+ functional TR (graded from 0 to 3+) underwent either B-TVA (n = 345; mean EuroSCORE II 9...
July 2016: Interactive Cardiovascular and Thoracic Surgery
https://www.readbyqxmd.com/read/26914583/-exercise-training-in-the-therapy-of-heart-diseases-current-evidence-and-future-options
#18
S Schwarz, A Boscheri, J Christle, A Duvinage, K Esefeld, H Fricke, N Pitsch, A Pressler, M Weichenberger, M Halle
Exercise training has been firmly established as an additional therapeutic strategy in addition to pharmacological and interventional treatment in patients with cardiovascular disease. Benefits for quality of life as well as prognosis have been confirmed for cardiovascular risk factors, ischemic heart disease, after myocardial infarction, in heart failure with preserved as well as reduced ejection fraction, in atrial fibrillation and in patients after catheter-assisted aortic valve implantation (TAVI), with an implantable cardioverter defibrillator (ICD) or with left ventricular assist devices (VAD)...
March 2016: Herz
https://www.readbyqxmd.com/read/26843026/natural-history-of-107-cases-of-fetal-aortic-stenosis-from-a-european-multicenter-retrospective-study
#19
H M Gardiner, A Kovacevic, G Tulzer, T Sarkola, U Herberg, J Dangel, A Öhman, J Bartrons, J S Carvalho, H Jicinska, V Fesslova, I Averiss, M Mellander
OBJECTIVES: Fetal aortic valvuloplasty (FV) aims to prevent fetal aortic valve stenosis progressing into hypoplastic left heart syndrome (HLHS), which results in postnatal univentricular (UV) circulation. Despite increasing numbers of FVs performed worldwide, the natural history of the disease in fetal life remains poorly defined. The primary aim of this study was to describe the natural history of fetal aortic stenosis, and a secondary aim was to test previously published criteria designed to identify cases of emerging HLHS with the potential for a biventricular (BV) outcome after FV...
September 2016: Ultrasound in Obstetrics & Gynecology
https://www.readbyqxmd.com/read/26831678/two-and-three-dimensional-transoesophageal-echocardiography-in-large-swine-used-as-model-for-transcatheter-heart-valve-therapies-standard-planes-and-values
#20
Simon H Sündermann, Nikola Cesarovic, Volkmar Falk, Dominique Bettex
OBJECTIVES: Swine models are widely used to develop new techniques and materials for the treatment of heart valve disease like aortic valve and mitral valve transcatheter interventions and to train physicians in these techniques. Transoesophageal echocardiography (TOE) is crucial in these models. We defined standard planes of 2D and 3D TOE in healthy pigs undergoing transcatheter heart valve interventions. METHODS: Twenty healthy pigs (weight 56-106 kg) underwent different mitral and aortic valve interventions (transcatheter aortic valve implantations, implantations of a mitral band, bicuspidization of the aortic valve, trans-septal punctures)...
May 2016: Interactive Cardiovascular and Thoracic Surgery
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