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Mitraclip, percutaneous mitral valve

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https://www.readbyqxmd.com/read/28706742/pulmonary-hemorrhage-following-edge-to-edge-mitral-valve-repair
#1
Mirna B Ayache, Myttle A Mayuga, Chantal ElAmm, Guilherme Attizzani, Jordan Kazakov
Mitral valve repair with the MitraClip device has emerged as an effective treatment option for patients with severe mitral regurgitation and contraindications for surgical interventions. While the procedure is not known to cause pulmonary complications, we describe two cases of pulmonary hemorrhage following percutaneous mitral valve repair. The patients did well with supportive care and reinitiation of anticlotting agents was well tolerated after resolution of bleeding.
2017: Case Reports in Cardiology
https://www.readbyqxmd.com/read/28698288/impact-of-forward-stroke-volume-response-on-clinical-and-structural-outcomes-after-percutaneous-mitral-valve-repair-with-mitraclip
#2
Shunsuke Kubo, Mamoo Nakamura, Takahiro Shiota, Yuji Itabashi, Yukiko Mizutani, Yoshifumi Nakajima, Krissada Meemook, Asma Hussaini, Moody Makar, Robert J Siegel, Saibal Kar
BACKGROUND: An increase of systolic forward flow was frequently observed after successful MitraClip implantation in patients with significant mitral regurgitation. However, the impact of systolic forward flow improvement on post-MitraClip outcomes remains unknown. METHODS AND RESULTS: Study population included 160 patients who underwent successful MitraClip implantation. The systolic forward flow was noninvasively calculated as the forward stroke volume (FSV) at baseline before the MitraClip procedure and before discharge with pulse-wave Doppler using transthoracic echocardiography...
July 2017: Circulation. Cardiovascular Interventions
https://www.readbyqxmd.com/read/28689751/postprocedural-changes-of-tricuspid-regurgitation-after-mitraclip-therapy-for-mitral-regurgitation
#3
Kentaro Toyama, Kengo Ayabe, Saibal Kar, Shunsuke Kubo, Toshinori Minamishima, Florian Rader, Takahiro Shiota, Toshihiko Nishioka, Robert J Siegel
The effect of percutaneous mitral valve repair using the MitraClip system on tricuspid regurgitation (TR) has not been well investigated. We retrospectively analyzed 102 consecutive patients who underwent the successful MitraClip procedure, and who also had a preprocedural and 1-year follow-up transthoracic echocardiography. TR severity was graded by standard guideline-recommended criteria. At 1 year after the MitraClip procedure, the degree of TR regressed (at least 1 grade) in 23% of the patients, was unchanged in 62% of the patients, and progressed in 16% of the patients...
June 15, 2017: American Journal of Cardiology
https://www.readbyqxmd.com/read/28678148/effects-of-levosimendan-in-patients-with-severe-functional-mitral-regurgitation-undergoing-mitraclip-implantation
#4
Cristina Giannini, Anna S Petronio, Francesca Fiorelli, Riccardo Liga, Paolo Spontoni, Marco De Carlo, Emilia Marraccini, Andrea Pieroni, Fabio Guarracino
AIM: Percutaneous mitral valve repair (PMVR) with a MitraClip device has been recently introduced as a valuable therapy in high surgical risk patients with functional mitral regurgitation (FMR) who are not responding to currently available medical treatments. Our aim was to assess the clinical, functional and prognostic impact of periprocedural levosimendan administration in patients with end-stage heart failure and FMR undergoing PMVR. METHODS: Between December 2009 and August 2016, 94 consecutive high-risk patients with symptomatic FMR who underwent PMVR with the MitraClip System at our center were enrolled in a prospective registry...
July 3, 2017: Journal of Cardiovascular Medicine
https://www.readbyqxmd.com/read/28675000/the-mitral-to-aortic-flow-velocity-integral-ratio-in-the-real-world-echocardiographic-evaluation-of-functional-mitral-regurgitation-before-and-after-percutaneous-repair
#5
Giuseppe Palmiero, Luigi Ascione, Carlo Briguori, Guido Carlomagno, Chiara Sordelli, Raffaele Ascione, Francesca Pisacane, Vittorio Monda, Sergio Severino, Pio Caso
INTRODUCTION: Percutaneous mitral valve repair (PMVR) using MitraClip system has emerged as a therapeutic option for patients with functional severe mitral regurgitation (FMR) at prohibitive risk for surgery. In this setting, the echocardiographic assessment of FMR severity is challenging because the traditional echocardiographic methods have important limitations. The aim of this study was to assess the accuracy and reliability of a simple Doppler index, the mitral/aortic flow velocity integral ratio (MAVIR), to evaluate residual FMR severity after PMVR...
July 3, 2017: Journal of Interventional Cardiology
https://www.readbyqxmd.com/read/28673783/combined-mitraclip-implantation-and-left-atrial-appendage-occlusion-using-the-watchman-device-a-case-series-from-a-referral-center
#6
Ana Rita G Francisco, Eduardo Infante de Oliveira, Miguel Nobre Menezes, Pedro Carrilho Ferreira, Pedro Canas da Silva, Ângelo Nobre, Fausto J Pinto
INTRODUCTION: Patients referred for percutaneous transcatheter mitral valve repair using the MitraClip(®) system frequently have atrial fibrillation, which imposes additional challenges due to the need for oral anticoagulation. Left atrial appendage occlusion is currently regarded as a non-inferior alternative to anticoagulation in patients with non-valvular atrial fibrillation and both high thromboembolic and bleeding risk. Considering that both MitraClip implantation and left atrial appendage occlusion are percutaneous techniques that require transseptal puncture, it is technically attractive to consider their concomitant use...
June 30, 2017: Portuguese Journal of Cardiology: An Official Journal of the Portuguese Society of Cardiology
https://www.readbyqxmd.com/read/28673638/effect-of-percutaneous-edge-to-edge-repair-on-mitral-valve-area-and-its-association-with-pulmonary-hypertension-and-outcomes
#7
Hiroto Utsunomiya, Yuji Itabashi, Sayuki Kobayashi, Florian Rader, Asma Hussaini, Moody Makar, Alfredo Trento, Robert J Siegel, Saibal Kar, Takahiro Shiota
Percutaneous edge-to-edge repair using the MitraClip system causes reduction in mitral valve area (MVA). However, its clinical impact is not fully elucidated. This study assessed the impact of postprocedural MVA reduction on pulmonary hypertension and outcomes. A total of 92 patients with grades 3 to 4 + mitral regurgitation (MR) who underwent MitraClip therapy were retrospectively reviewed. Using intraprocedural, 3-dimensional transesophageal echocardiography, postprocedural MVA was obtained by 2 optimized planes through the medial and lateral orifices of the repaired valve...
May 30, 2017: American Journal of Cardiology
https://www.readbyqxmd.com/read/28663365/outcome-after-percutaneous-edge-to-edge-mitral-repair-for-functional-and-degenerative-mitral-regurgitation-a-systematic-review-and-meta-analysis
#8
Mauro Chiarito, Matteo Pagnesi, Enrico Antonio Martino, Michele Pighi, Andrea Scotti, Giuseppe Biondi-Zoccai, Azeem Latib, Giovanni Landoni, Carlo Di Mario, Alberto Margonato, Francesco Maisano, Ted Feldman, Ottavio Alfieri, Antonio Colombo, Cosmo Godino
OBJECTIVES: Differences in terms of safety and efficacy of percutaneous edge-to-edge mitral repair between patients with functional and degenerative mitral regurgitation (MR) are not well established. We performed a systematic review and meta-analysis to clarify these differences. METHODS: PubMed, EMBASE, Google scholar database and international meeting abstracts were searched for all studies about MitraClip. Studies with <25 patients or where 1-year results were not delineated between MR aetiology were excluded...
June 29, 2017: Heart: Official Journal of the British Cardiac Society
https://www.readbyqxmd.com/read/28612452/unusual-interatrial-membrane-in-the-left-atrium-a-newer-obstacle-for-transseptal-based-percutaneous-mitral-valve-repair-techniques
#9
Antonio Popolo Rubbio, Sarah Mangiafico, Salvatore Scandura, Sergio Buccheri, Marco Barbanti, Giuseppe Ronsivalle, Maria Elena Di Salvo, Marta Chiarandà, Tatiana Salerno, Anna Caggegi, Sandra Giaquinta, Davide Capodanno, Carmelo Grasso, Corrado Tamburino
We present a case of a patient with severe mitral regurgitation referred to our Institution for an echocardiographic examination as part of the routine workup to assess the eligibility for mitral valve percutaneous repair with either the MitraClip or Cardioband systems. Echocardiography showed the presence of an unusual interatrial membrane in the left atrium that represented a contraindication for the puncture of the interatrial septum. The patient was finally deferred to percutaneous mitral valve replacement using transapical access...
June 13, 2017: Echocardiography
https://www.readbyqxmd.com/read/28600091/transcatheter-aortic-valve-replacement-and-mitraclip-to-reverse-heart-failure
#10
REVIEW
Sukhdeep Basra, Molly Szerlip
Valvular heart diseases such as aortic stenosis and mitral regurgitation are often associated with heart failure, which in turn increases patients' Surgical Thoracic Society (STS) score. A high STS score means the patient is high risk for surgical aortic valve replacement and mitral valve repair/replacement. Transcatheter aortic valve replacement and percutaneous mitral valve repair offer a minimally invasive alternative for the treatment of valvular heart disease in patients with severe heart failure. We aim to review the current evidence on the safety, efficacy, and outcomes of these devices in patients with severe heart failure...
July 2017: Interventional cardiology clinics
https://www.readbyqxmd.com/read/28504238/united-kingdom-coronary-and-structural-heart-interventions-from-2010-to-2015
#11
Peter F Ludman, Mark A de Belder, Simon Redwood, Adrian Banning
In the United Kingdom, a clinical data set is completed for every patient undergoing coronary intervention and certain structural interventions, and sent to central servers in the National Institute for Cardiovascular Outcomes Research (NICOR) on behalf of the British Cardiovascular Intervention Society (BCIS). These data are linked to the national mortality register. In addition, data are obtained about the structure of healthcare provision using an annual survey. Analyses of these data are provided for different audiences in several formats...
May 15, 2017: EuroIntervention
https://www.readbyqxmd.com/read/28481153/von-willebrand-factor-as-a-novel-player-in-valvular-heart-disease-from-bench-to-valve-replacement
#12
Felice Gragnano, Mario Crisci, Maurizio Cappelli Bigazzi, Renatomaria Bianchi, Simona Sperlongano, Francesco Natale, Fabio Fimiani, Claudia Concilio, Arturo Cesaro, Ivana Pariggiano, Vincenzo Diana, Giuseppe Limongelli, Plinio Cirillo, Mariagiovanna Russo, Enrica Golia, Paolo Calabrò
von Willebrand Factor (vWF) is a well-known mediator of hemostasis and vascular inflammation. Its dynamic modulation in the bloodstream, according to hemodynamic conditions, makes it an appealing biomarker in patients with valvular heart disease (VHD). Recent studies highlight the close connection between vWF and VHD, with possible implications in the pathogenesis of VHD, promoting valve aging and calcification or favoring the development of infective endocarditis. Moreover, vWF has been recently proposed as a new diagnostic and prognostic tool in patients with valve stenosis or regurgitation, showing a strict correlation with severity of valve disease, outcome, and bleeding (Heyde syndrome)...
January 1, 2017: Angiology
https://www.readbyqxmd.com/read/28473116/elevated-mitral-valve-pressure-gradient-after-mitraclip-implantation-deteriorates-long-term-outcome-in-patients-with-severe-mitral-regurgitation-and-severe%C3%A2-heart-failure
#13
Michael Neuss, Thomas Schau, Akihiro Isotani, Markus Pilz, Maren Schöpp, Christian Butter
OBJECTIVES: This single-center study was performed to analyze the effect of an increased transvalvular gradient after the MitraClip (MC) (Abbott Laboratories, Abbott Park, Illinois) procedure on patient outcome during follow-up. BACKGROUND: Percutaneous transcatheter repair of the mitral valve with the MC device has been established as a novel technique for patients with severe mitral regurgitation and high surgical risk. This study investigated the influence of an increased pressure gradient after MC implantation on the long-term outcome of patients...
May 8, 2017: JACC. Cardiovascular Interventions
https://www.readbyqxmd.com/read/28391261/end-tidal-co2-predicts-reduction-in-mitral-regurgitation-in-patients-undergoing-percutaneous-mitral-valve-edge-to-edge-repair
#14
Michael Huntgeburth, Robert Schier, Roman Pfister, Henrik Ten Freyhaus, Kristina Dahlem, Kai Friedrichs, Stephan Baldus, Volker Rudolph
OBJECTIVES: We evaluated end-tidal CO2 (etCO2), which has been proposed to assess acute hemodynamic changes, to guide percutaneous edge-to-edge mitral valve repair (PMVR) with the MitraClip system. METHODS: Thirty-nine patients (aged 78 ± 14 years) undergoing PMVR for moderate-to-severe mitral regurgitation (MR) of primary and secondary etiology were included. General anesthesia was maintained with sevoflurane and constant ventilation parameters to ensure stable etCO2 tension...
2017: Cardiology
https://www.readbyqxmd.com/read/28374178/current-status-of-catheter-based-treatment-of-mitral-valve-regurgitation
#15
REVIEW
Mario Gössl, Robert S Farivar, Richard Bae, Paul Sorajja
PURPOSE OF REVIEW: This review examines the current status of catheter-based repair and replacement for mitral valve disease, with a focus on native primary and secondary mitral valve regurgitation. RECENT FINDINGS: Transcatheter mitral valve repair with the MitraClip®, with >40,000 performed procedures worldwide, has significantly advanced the field of transcatheter therapy for mitral valve regurgitation. Transcatheter mitral valve replacement remains in the early stages of development, mainly due to the complex anatomy and physiology of the mitral valve...
May 2017: Current Cardiology Reports
https://www.readbyqxmd.com/read/28368846/percutaneous-mitral-valve-repair-with-the-mitraclip-in-primary-compared-with-secondary-mitral-valve-regurgitation-using-the-mitral-valve-academic-research-consortium-criteria
#16
Julia Seeger, Patrick Müller, Birgid Gonska, Dominik Scharnbeck, Sinisa Markovic, Daniel Walcher, Wolfgang Rottbauer, Jochen Wöhrle
AIMS: To compare early device success, procedural success, and 30-day safety endpoint according to the new Mitral Valve Academic Research Consortium criteria (MVARC) in severe primary and secondary mitral regurgitation (MR) patients. METHODS AND RESULTS: A total of 210 patients were enrolled; 105 patients with primary MR were compared with 105 patients with secondary MR. All patients were highly symptomatic (New York Heart Association III/IV 79.0% vs 87.6%). Decision for MitraClip therapy was done by the heart team...
April 2017: Journal of Invasive Cardiology
https://www.readbyqxmd.com/read/28324874/strategies-and-outcomes-of-repeat-mitral-valve-interventions-after-failed-mitraclip-therapy
#17
Carmelo Grasso, Sergio Buccheri, Davide Capodanno, Antonio Popolo Rubbio, Maria Elena Di Salvo, Salvatore Scandura, Sarah Mangiafico, Tatiana Salerno, Stefano Cannata, Veronica Dezio, Giuseppe Castania, Marco Barbanti, Piera Capranzano, Corrado Tamburino
Percutaneous mitral valve repair (PMVR) with the MitraClip system (Abbott Vascular, Santa Clara, CA, USA) is a valid therapeutic option for patients with severe mitral regurgitation (MR) deemed to be at high or prohibitive surgical risk. Despite the reassuring data on efficacy and long-term durability of the procedure, the proportion of patients with residual or relapsing severe MR after MitraClip therapy is not negligible. In light of the detrimental prognostic impact of severe MR, repeat interventions are increasingly performed in clinical practice using different techniques...
2017: Cardiology
https://www.readbyqxmd.com/read/28317788/current-status-of-transcatheter-mitral-valve-therapy-in-europe-results-from-an-eapci-survey-part-ii
#18
Anna Sonia Petronio, Piera Capranzano, Emanuele Barbato, Nicolò Piazza, Andreas Baumbach, Michael Haude, Stephan Windecker
AIMS: The European Association of Percutaneous Coronary Interventions (EAPCI) assessed the current status of transcatheter valve therapy in Europe through a web-based survey. Our aim here was to report the results of that survey regarding trends in percutaneous mitral valve repair (PMVR) therapy. METHODS AND RESULTS: Among 301 European centres participating in the overall EAPCI survey, 246 (81.7%) responded to the PMVR section questions. A total of 176 (71.5%) have been undertaking a PMVR programme...
March 20, 2017: EuroIntervention
https://www.readbyqxmd.com/read/28286089/conventional-surgery-for-early-and-late-symptomatic-mitral-valve-stenosis-after-mitraclip-%C3%A2-intervention-an-institutional-experience-with-four-consecutive-patients
#19
Anthony Alozie, Liliya Paranskaya, Bernd Westphal, Alexander Kaminski, Gustav Steinhoff, Mohammad Sherif, Hüseyin Ince, Alper Öner
BACKGROUND: Surgical mitral valve repair is the gold standard for treatment of mitral regurgitation. Recently, the transcatheter treatment of mitral regurgitation with the MitraClip(®) device (Abbot Vascular Structural Heart, Menlo Park, CA) has demonstrated promising results in treating patients not amenable for surgical correction of mitral valve regurgitation. Most patients reported in the literature requiring surgical bailout after MitraClip treatment presented with residual or recurrent mitral valve regurgitation...
February 17, 2017: Heart, Lung & Circulation
https://www.readbyqxmd.com/read/28283362/syntax-score-ii-in-patients-with-coronary-artery-disease-undergoing-percutaneous-mitral-repair-with-the-mitraclip
#20
Slayman Obeid, Adrian Attinger-Toller, Maurizio Taramasso, Giovanni Pedrazzini, Gabor Suetsch, Fabienne Landolt, Fatih Karbeyaz, Hector Rodriguez, Daniel Sürder, Tiziano Moccetti, Fabian Nietlispach, Francesco Maisano
BACKGROUND: Percutaneous mitral valve repair (PMVR) using the MitraClip™ system has become a valuable alternative in patients with severe mitral regurgitation (MR) and high surgical risk. We sought to evaluate the prognostic value of the SYNTAX II score (SSII) in patients with concomitant coronary artery disease (CAD) undergoing a Mitraclip procedure. METHODS: In seventy-five consecutive patients who underwent PMVR at the University Heart Center Zürich and the Cardiocentro Ticino, the SSSII was calculated at baseline...
February 24, 2017: International Journal of Cardiology
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