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Mitraclip, percutaneous mitral valve

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https://www.readbyqxmd.com/read/29027267/percutaneous-repair-of-severe-mitral-valve-regurgitation-secondary-to-chordae-rupture-in-octogenarians-using-mitraclip
#1
Nicolas Geis, Philip Raake, Derliz Mereles, Emmanuel Chorianopoulos, Gabor Szabo, Hugo A Katus, Raffi Bekeredjian, Sven T Pleger
OBJECTIVES: The aim of this study was to assess feasibility and clinical effectiveness of the MitraClip device in octogenarians suffering from severe mitral valve regurgitation due to chordae rupture. BACKGROUND: The MitraClip procedure is a suitable technique in high-risk surgical patients to achieve safe and effective percutaneous repair of mitral valve regurgitation. Octogenarians show cumulative risk and social aspects hindering mitral valve surgery. No data exists regarding the use of the MitraClip device in high-risk octogenarians suffering from mitral valve chordae rupture...
October 12, 2017: Journal of Interventional Cardiology
https://www.readbyqxmd.com/read/29025679/relation-of-residual-mitral-regurgitation-despite-elevated-mitral-gradients-to-risk-of-heart-failure-hospitalization-after-mitraclip-repair
#2
Richard Cheng, Sam Dawkins, Emily Tat, Moody Makar, Asma Hussaini, Raj R Makkar, Alfredo Trento, Robert J Siegel, Saibal Kar
Achieving minimal residual mitral regurgitation (MR) after percutaneous MitraClip repair is limited by iatrogenic mitral stenosis. It is unknown whether allowing moderately elevated postprocedural mean mitral gradients (MMGs) to achieve < moderate residual MR is preferable to moderate residual regurgitation. Patients with less-than-moderate residual MR but a MMG of ≥5 mm Hg (Group 1) were compared with patients with moderate residual MR (Group 2). The primary end point was heart failure hospitalization...
November 1, 2017: American Journal of Cardiology
https://www.readbyqxmd.com/read/28977372/improved-mitral-valve-coaptation-and-reduced-mitral-valve-annular-size-after-percutaneous-mitral-valve-repair-pmvr-using-the-mitraclip-system
#3
Johannes Patzelt, Yingying Zhang, Harry Magunia, Miriam Ulrich, Rezo Jorbenadze, Michal Droppa, Wenzhong Zhang, Henning Lausberg, Tobias Walker, Peter Rosenberger, Peter Seizer, Meinrad Gawaz, Harald F Langer
Aims: Improved mitral valve leaflet coaptation with consecutive reduction of mitral regurgitation (MR) is a central goal of percutaneous mitral valve repair (PMVR) with the MitraClip® system. As influences of PMVR on mitral valve geometry have been suggested before, we examined the effect of the procedure on mitral annular size in relation to procedural outcome. Methods and results: Geometry of the mitral valve annulus was evaluated in 183 patients undergoing PMVR using echocardiography before and after the procedure and at follow-up...
August 1, 2017: European Heart Journal Cardiovascular Imaging
https://www.readbyqxmd.com/read/28895061/valvular-heart-disease-in-women-differential-remodeling-and-response-to-new-therapies
#4
REVIEW
Jaya Chandrasekhar, George Dangas, Roxana Mehran
In the United States, valvular heart disease (VHD) has a prevalence of 2.5%, most commonly presenting as aortic stenosis (AS) or mitral valve regurgitation (MR) and increasingly observed to be of a degenerative etiology. Women frequently have latent symptoms despite significant disease, and it is therefore pertinent to consider both clinical symptoms and imaging findings for decision-making on treatment. Indeed, significant advances have been made in noninvasive imaging allowing for more accurate diagnosis and disease prognostication...
September 11, 2017: Current Treatment Options in Cardiovascular Medicine
https://www.readbyqxmd.com/read/28863973/current-status-of-mitraclip-for-patients-with-mitral-and-tricuspid-regurgitation
#5
REVIEW
Sidakpal S Panaich, Mackram F Eleid
Mitral valve regurgitation (MR) affects approximately 4 million people in the United States alone, increasing in prevalence with age. Approved by the Food and Drug Administration (FDA) in October 2013, percutaneous edge-to-edge transcatheter mitral valve repair (also known as the MitraClip system) has been used in over 40,000 patients globally. Additionally, there is keen interest and early exploration into the use of MitraClip for treatment of severe symptomatic tricuspid regurgitation, another undertreated disease with significant morbidity and mortality...
August 18, 2017: Trends in Cardiovascular Medicine
https://www.readbyqxmd.com/read/28852577/sequential-venous-percutaneous-transluminal-angioplasty-and-balloon-dilatation-of-the-interatrial-septum-during-percutaneous-edge-to-edge-mitral-valve-repair
#6
Rezo Jorbenadze, Johannes Patzelt, Meinrad Gawaz, Peter Seizer, Harald F Langer
Percutaneous edge-to-edge mitral valve repair (PMVR) is widely used for selected, high-risk patients with severe mitral valve regurgitation (MR). This report describes a case of 81-year-old woman presenting with severe and highly symptomatic mitral valve regurgitation (MR) caused by a flail of the posterior mitral valve leaflet (PML). PMVR turned out to be challenging in this patient because of a stenosis and tortuosity of both iliac veins as well as sclerosis of the interatrial septum, precluding the vascular and left atrial access by standard methods, respectively...
2017: Case Reports in Cardiology
https://www.readbyqxmd.com/read/28834079/safety-and-efficacy-of-mitraclip%C3%A2-therapy-in-patients-with-severely-impaired-left-ventricular-ejection-fraction-results-from-the-german-transcatheter-mitral-valve-interventions-trami-registry
#7
Nicolas A Geis, Miriam Puls, Edith Lubos, Christine S Zuern, Jennifer Franke, Robert Schueler, Ralph S von Bardeleben, Peter Boekstegers, Taoufik Ouarrak, Ralf Zahn, Hüseyin Ince, Jochen Senges, Hugo A Katus, Raffi Bekeredjian
AIMS: The aim of the present study was to assess the safety and efficacy of percutaneous mitral valve repair using the MitraClip™ device in patients with severely reduced systolic left ventricular (LV) function. METHODS AND RESULTS: Among 777 MitraClip™ implantations included in the German mitral valve registry, we identified 256 patients suffering from severely reduced LV function [ejection fraction (EF) <30%] in whom successful percutaneous mitral valve repair was performed...
August 18, 2017: European Journal of Heart Failure
https://www.readbyqxmd.com/read/28820547/incidence-and-clinical-impact-of-cerebral-lesions-after-the-mitraclip%C3%A3-%C3%A2-procedure
#8
Sebastian Barth, Karsten Hamm, Stefan Fodor, Wilko Reents, Sebastian Kerber, Philipp Halbfass, Martina B Hautmann, Bernhard Schieffer, Hassan Soda
BACKGROUND: Clinically silent brain injury detected with cerebral magnetic resonance imaging (MRI) is well known after various cardiovascular interventions. Thus far, only one study has examined the periprocedural risk of cerebral ischemic events in patients undergoing percutaneous mitral valve reconstruction. The study aim was to examine the incidence and clinical impact of cerebral embolic events in patients undergoing percutaneous mitral valve reconstruction using the MitraClip® system...
March 2017: Journal of Heart Valve Disease
https://www.readbyqxmd.com/read/28820546/initial-results-of-combined-mitraclip%C3%A3-%C3%A2-implantation-and-left-atrial-appendage-occlusion
#9
Xavier Freixa, Rodrigo Estévez-Loureiro, Fernando Carrasco-Chinchilla, Dabit Arzamendi, Pilar Jiménez-Quevedo, Luis Nombela-Franco, Ignacio Cruz-González, Ignacio J Amat-Santos, Manel Sabaté
BACKGROUND: Atrial fibrillation is present in 30-50% of patients undergoing percutaneous mitral valve repair. The presence of a formal contraindication to oral anticoagulation is also very common in these patients. In this context, percutaneous left atrial appendage occlusion (LAAO) may be a valid alternative for these patients. The study aim was to assess the feasibility, safety, and technical considerations of the combination of percutaneous mitral valve repair using the MitraClip system and LAAO...
March 2017: Journal of Heart Valve Disease
https://www.readbyqxmd.com/read/28804054/elmstreet-esophageal-lesions-during-mitraclip%C3%A2-using-transesophagelechocardiography-trial
#10
Tobias Friedrich Ruf, Felix M Heidrich, Krunoslav M Sveric, Christian Pfluecke, Anna-Magdalena Stephan, Ruth H Strasser, Stephan Wiedemann
AIMS: We evaluated possible detrimental effects of transoesophageal echocardiography (TEE) on the oesophageal tissue during percutaneous mitral valve repair (PMVR). METHODS AND RESULTS: From March 2014 to July 2015, 186 patients were treated for severe mitral regurgitation (MR) with PMVR using the MitraClip® system. In 40 patients, esophagogastroduodenoscopy was performed due to symptoms related to the gastrointestinal tract. Based on the procedure's duration, patients were classified into group 1 (> 60 minutes, n=23) or into group 2 (< 60 minutes, n=17), respectively...
August 15, 2017: EuroIntervention
https://www.readbyqxmd.com/read/28770396/mitro-aortic-pathology-a%C3%A2-point-of-view-for-a%C3%A2-fully-transcatheter-staged-approach
#11
REVIEW
G D'Ancona, L Paranskaya, A Öner, S Kische, H Ince
Severe aortic valve stenosis (AVS) and mitral valve regurgitation (MVR) often coexist. Although a fully percutaneous treatment for the two conditions, by means of transcatheter aortic valve implantation (TAVI) followed by MitraClip, can be appealing in selected high-risk candidates, critical and strategical reasoning should be applied. In a 3-year period we have developed a single-centre experience of 14 patients who were managed with a staged percutaneous approach to treat severe AVS and MVR. The average interval from TAVI to MitraClip repair was 101 ± 12 days...
August 2, 2017: Netherlands Heart Journal
https://www.readbyqxmd.com/read/28762229/-percutaneous-edge-to-edge-mitral-valve-repair-new-transcatheter-approach-and-nursing-experience-in-patients-with-severe-mitral-regurgitation-and-prohibitive-surgical-risk
#12
Hsiu-Fen Huang, Hui-Yun Yu, Ching-Wei Lee, Hui-Chuang Chang, Mei-Ling Lin, Shin-Huey Wung
Open-heart surgery and conservative medical treatments have been the traditional, mainstay treatments for patients with severe mitral regurgitation (MR). Transcatheter edge-to-edge mitral repair is a novel technique. Using the transcatheter approach allows delivery of the clip into the left ventricle and the clipping of the orifice of the MR. The heart failure symptoms and outcomes of patients improve after this procedure. Compared to open-heart surgery, the mitral clip achieves similar MR reduction results with a significantly lower rate of complications...
August 2017: Hu Li za Zhi the Journal of Nursing
https://www.readbyqxmd.com/read/28706742/pulmonary-hemorrhage-following-edge-to-edge-mitral-valve-repair
#13
Mirna B Ayache, Myttle A Mayuga, Chantal ElAmm, Guilherme Attizzani, Jordan Kazakov
Mitral valve repair with the MitraClip device has emerged as an effective treatment option for patients with severe mitral regurgitation and contraindications for surgical interventions. While the procedure is not known to cause pulmonary complications, we describe two cases of pulmonary hemorrhage following percutaneous mitral valve repair. The patients did well with supportive care and reinitiation of anticlotting agents was well tolerated after resolution of bleeding.
2017: Case Reports in Cardiology
https://www.readbyqxmd.com/read/28698288/impact-of-forward-stroke-volume-response-on-clinical-and-structural-outcomes-after-percutaneous-mitral-valve-repair-with-mitraclip
#14
Shunsuke Kubo, Mamoo Nakamura, Takahiro Shiota, Yuji Itabashi, Yukiko Mizutani, Yoshifumi Nakajima, Krissada Meemook, Asma Hussaini, Moody Makar, Robert J Siegel, Saibal Kar
BACKGROUND: An increase of systolic forward flow was frequently observed after successful MitraClip implantation in patients with significant mitral regurgitation. However, the impact of systolic forward flow improvement on post-MitraClip outcomes remains unknown. METHODS AND RESULTS: Study population included 160 patients who underwent successful MitraClip implantation. The systolic forward flow was noninvasively calculated as the forward stroke volume (FSV) at baseline before the MitraClip procedure and before discharge with pulse-wave Doppler using transthoracic echocardiography...
July 2017: Circulation. Cardiovascular Interventions
https://www.readbyqxmd.com/read/28689751/postprocedural-changes-of-tricuspid-regurgitation-after-mitraclip-therapy-for-mitral-regurgitation
#15
MULTICENTER STUDY
Kentaro Toyama, Kengo Ayabe, Saibal Kar, Shunsuke Kubo, Toshinori Minamishima, Florian Rader, Takahiro Shiota, Toshihiko Nishioka, Robert J Siegel
The effect of percutaneous mitral valve repair using the MitraClip system on tricuspid regurgitation (TR) has not been well investigated. We retrospectively analyzed 102 consecutive patients who underwent the successful MitraClip procedure, and who also had a preprocedural and 1-year follow-up transthoracic echocardiography. TR severity was graded by standard guideline-recommended criteria. At 1 year after the MitraClip procedure, the degree of TR regressed (at least 1 grade) in 23% of the patients, was unchanged in 62% of the patients, and progressed in 16% of the patients...
September 1, 2017: American Journal of Cardiology
https://www.readbyqxmd.com/read/28678148/effects-of-levosimendan-in-patients-with-severe-functional-mitral-regurgitation-undergoing-mitraclip-implantation
#16
Cristina Giannini, Anna S Petronio, Francesca Fiorelli, Riccardo Liga, Paolo Spontoni, Marco De Carlo, Emilia Marraccini, Andrea Pieroni, Fabio Guarracino
AIM: Percutaneous mitral valve repair (PMVR) with a MitraClip device has been recently introduced as a valuable therapy in high surgical risk patients with functional mitral regurgitation (FMR) who are not responding to currently available medical treatments. Our aim was to assess the clinical, functional and prognostic impact of periprocedural levosimendan administration in patients with end-stage heart failure and FMR undergoing PMVR. METHODS: Between December 2009 and August 2016, 94 consecutive high-risk patients with symptomatic FMR who underwent PMVR with the MitraClip System at our center were enrolled in a prospective registry...
September 2017: Journal of Cardiovascular Medicine
https://www.readbyqxmd.com/read/28675000/the-mitral-to-aortic-flow-velocity-integral-ratio-in-the-real-world-echocardiographic-evaluation-of-functional-mitral-regurgitation-before-and-after-percutaneous-repair
#17
Giuseppe Palmiero, Luigi Ascione, Carlo Briguori, Guido Carlomagno, Chiara Sordelli, Raffaele Ascione, Francesca Pisacane, Vittorio Monda, Sergio Severino, Pio Caso
INTRODUCTION: Percutaneous mitral valve repair (PMVR) using MitraClip system has emerged as a therapeutic option for patients with functional severe mitral regurgitation (FMR) at prohibitive risk for surgery. In this setting, the echocardiographic assessment of FMR severity is challenging because the traditional echocardiographic methods have important limitations. The aim of this study was to assess the accuracy and reliability of a simple Doppler index, the mitral/aortic flow velocity integral ratio (MAVIR), to evaluate residual FMR severity after PMVR...
August 2017: Journal of Interventional Cardiology
https://www.readbyqxmd.com/read/28673783/combined-mitraclip-implantation-and-left-atrial-appendage-occlusion-using-the-watchman-device-a-case-series-from-a-referral-center
#18
Ana Rita G Francisco, Eduardo Infante de Oliveira, Miguel Nobre Menezes, Pedro Carrilho Ferreira, Pedro Canas da Silva, Ângelo Nobre, Fausto J Pinto
INTRODUCTION: Patients referred for percutaneous transcatheter mitral valve repair using the MitraClip(®) system frequently have atrial fibrillation, which imposes additional challenges due to the need for oral anticoagulation. Left atrial appendage occlusion is currently regarded as a non-inferior alternative to anticoagulation in patients with non-valvular atrial fibrillation and both high thromboembolic and bleeding risk. Considering that both MitraClip implantation and left atrial appendage occlusion are percutaneous techniques that require transseptal puncture, it is technically attractive to consider their concomitant use...
July 2017: Portuguese Journal of Cardiology: An Official Journal of the Portuguese Society of Cardiology
https://www.readbyqxmd.com/read/28673638/effect-of-percutaneous-edge-to-edge-repair-on-mitral-valve-area-and-its-association-with-pulmonary-hypertension-and-outcomes
#19
Hiroto Utsunomiya, Yuji Itabashi, Sayuki Kobayashi, Florian Rader, Asma Hussaini, Moody Makar, Alfredo Trento, Robert J Siegel, Saibal Kar, Takahiro Shiota
Percutaneous edge-to-edge repair using the MitraClip system causes reduction in mitral valve area (MVA). However, its clinical impact is not fully elucidated. This study assessed the impact of postprocedural MVA reduction on pulmonary hypertension and outcomes. A total of 92 patients with grades 3 to 4 + mitral regurgitation (MR) who underwent MitraClip therapy were retrospectively reviewed. Using intraprocedural, 3-dimensional transesophageal echocardiography, postprocedural MVA was obtained by 2 optimized planes through the medial and lateral orifices of the repaired valve...
August 15, 2017: American Journal of Cardiology
https://www.readbyqxmd.com/read/28663365/outcome-after-percutaneous-edge-to-edge-mitral-repair-for-functional-and-degenerative-mitral-regurgitation-a-systematic-review-and-meta-analysis
#20
Mauro Chiarito, Matteo Pagnesi, Enrico Antonio Martino, Michele Pighi, Andrea Scotti, Giuseppe Biondi-Zoccai, Azeem Latib, Giovanni Landoni, Carlo Di Mario, Alberto Margonato, Francesco Maisano, Ted Feldman, Ottavio Alfieri, Antonio Colombo, Cosmo Godino
OBJECTIVES: Differences in terms of safety and efficacy of percutaneous edge-to-edge mitral repair between patients with functional and degenerative mitral regurgitation (MR) are not well established. We performed a systematic review and meta-analysis to clarify these differences. METHODS: PubMed, EMBASE, Google scholar database and international meeting abstracts were searched for all studies about MitraClip. Studies with <25 patients or where 1-year results were not delineated between MR aetiology were excluded...
June 29, 2017: Heart: Official Journal of the British Cardiac Society
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