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Mitraclip, percutaneous mitral valve

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https://www.readbyqxmd.com/read/29676043/mitral-valve-interventions-in-heart-failure
#1
REVIEW
Daniel Lavall, Andreas Hagendorff, Stephan H Schirmer, Michael Böhm, Michael A Borger, Ulrich Laufs
Secondary mitral regurgitation (MR) results from left ventricular dilatation and dysfunction. Quantification of secondary MR is challenging because of the underlying myocardial disease. Clinical and echocardiographic evaluation requires a multi-parametric approach. Severe secondary MR occurs in up to one-fourth of patients with heart failure with reduced ejection fraction, which is associated with a mortality rate of 40% to 50% in 3 years. Percutaneous edge-to-edge mitral valve repair (MitraClip) has emerged as an alternative to surgical valve repair to improve symptoms, functional capacity, heart failure hospitalizations, and cardiac haemodynamics...
April 19, 2018: ESC Heart Failure
https://www.readbyqxmd.com/read/29663512/specific-biomarkers-of-myocardial-inflammation-and-remodeling-processes-as-predictors-of-mortality-in-high-risk-patients-undergoing-percutaneous-mitral-valve-repair-mitraclip
#2
Oliver Dörr, Claudia Walther, Christoph Liebetrau, Till Keller, Hannes Tabert, Niklas Boeder, Matthias Bayer, Pascal Bauer, Helge Möllmann, Luise Gaede, Christian Troidl, Sandra Voss, Timm Bauer, Christian W Hamm, Holger Nef
BACKGROUND: Specific matrix metalloproteinases (MMP-2, MMP-9) and inflammatory biomarkers (hsCRP, IL-6) were found to be consistently up-regulated in severe mitral valve regurgitation (MR) and are associated with mortality in heart failure patients. The aim of the present study was to examine the prognostic value of biomarkers of cardiac inflammation and remodeling processes in predicting mortality in patients with MR undergoing percutaneous mitral valve repair (PMVR). HYPOTHESIS: We hypothesize that increased cardiac inflammation and extracellular matrix turnover is predictive for mortality in patients with severe mitral regurgitation undergoing MitraClip...
April 17, 2018: Clinical Cardiology
https://www.readbyqxmd.com/read/29650238/incidence-timing-causes-and-predictors-of-early-and-late-re-hospitalization-in-patients-who-underwent-percutaneous-mitral-valve-repair-with-the-mitraclip-system
#3
Carmelo Grasso, Antonio Popolo Rubbio, Davide Capodanno, Sergio Buccheri, Maria Elena Di Salvo, Stefano Cannata, Salvatore Scandura, Sarah Mangiafico, Silvia Farruggio, Tatiana Salerno, Jessica De Santis, Simona Sanalitro, Anna Caggegi, Giuseppe Castania, Marco Barbanti, Piera Capranzano, Corrado Tamburino
The pattern and reasons for re-hospitalization (RH) after MitraClip implantation are not well characterized. A total of 322 consecutive MitraClip patients were included, with data stratified by RH status. Multivariate analyses were conducted to identify predictors of early (30-day) and late (30-day to 12-month) RH. Eighty-nine patients (27.6%) were readmitted to hospital during the study period and early RH occurred in 27%. The median time from MitraClip to RH was 99 days. RH was mostly related to cardiovascular causes (66...
February 12, 2018: American Journal of Cardiology
https://www.readbyqxmd.com/read/29627105/utilization-in-hospital-mortality-and-30-day-readmission-after-percutaneous-mitral-valve-repair-in-the-united-states-shortly-after-device-approval
#4
Kamil F Faridi, Jeffrey J Popma, Jordan B Strom, Changyu Shen, Eunhee Choi, Robert W Yeh
The MitraClip device for percutaneous mitral valve repair was approved by the Food and Drug Administration in the United States in October 2013. Few studies have evaluated national outcomes after this procedure in routine clinical practice. We identified adults aged ≥18 years who received percutaneous mitral valve repair from November 2013 to December 2014 in the Nationwide Readmissions Database, a publicly available administrative claims database. Procedural volumes, number of performing hospitals, individual hospital volumes, in-hospital mortality rate, and 30-day hospital readmission rate were determined...
March 1, 2018: American Journal of Cardiology
https://www.readbyqxmd.com/read/29545259/distinct-hemodynamic-changes-after-interventional-mitral-valve-edge-to-edge-repair-in-different-phenotypes-of-heart-failure-an-integrated-hemodynamic-analysis
#5
Benedikt Schrage, Daniel Kalbacher, Michael Schwarzl, Nicole Rübsamen, Christoph Waldeyer, Peter Moritz Becher, Eike Tigges, Daniel Burkhoff, Stefan Blankenberg, Edith Lubos, Ulrich Schäfer, Dirk Westermann
BACKGROUND: Percutaneous mitral valve edge-to-edge repair (pMVR) with a MitraClip is beneficial for the clinical symptoms of patients irrespective of the ejection fraction (EF). Nevertheless, the consequences on hemodynamics are poorly understood. Therefore, we used data from noninvasive pressure-volume loops to investigate the left ventricular (LV) remodeling of patients after pMVR dependent on their baseline EF. METHODS AND RESULTS: In 130 patients with successful pMVR, the end-diastolic pressure-volume relationship (EDPVR) and end-systolic pressure-volume relationship were estimated noninvasively from echocardiographic data...
March 15, 2018: Journal of the American Heart Association
https://www.readbyqxmd.com/read/29545033/is-surgical-or-catheter-based-interventions-an-option-after-an-unsuccessful-mitral-clip
#6
Felix Kreidel, Hannes Alessandrini, Peter Wohlmuth, Michael Schmoeckel, Stephan Geidel
OBJECTIVE: To assess the results of catheter-based and surgical reintervention in primary mitral regurgitation (PMR) after failed MitraClip therapy. METHODS: We report on 21 consecutive symptomatic patients with PMR (median age 78 years) who underwent either repeat MitraClip therapy (n=7) or mitral valve surgery (n=14) after failure of the index procedure with 1-2 MitraClip implantations. At the time of reinterventions, 193 [IQR: 32 to 622] days after index procedure, patients had recurrent or persistent grade 3 MR...
March 12, 2018: Seminars in Thoracic and Cardiovascular Surgery
https://www.readbyqxmd.com/read/29482977/transcatheter-mitral-valve-repair-using-the-edge-to-edge-clip
#7
REVIEW
Charles B Nyman, G Burkhard Mackensen, Srdjan Jelacic, Stephen H Little, Thomas W Smith, Feroze Mahmood
Percutaneous intervention for mitral valve (MV) disease has been established as an alternative to open surgical MV repair in patients with prohibitive surgical risk. Multiple percutaneous approaches have been described and are in various stages of development. Edge-to-edge leaflet plication with the MitraClip (Abbott, Menlo Park, CA) is currently the only Food and Drug Administration-approved device specifically for primary or degenerative lesions. Use of the edge-to-edge clip for secondary mitral regurgitation is currently under investigation and may result in expanded indications...
April 2018: Journal of the American Society of Echocardiography
https://www.readbyqxmd.com/read/29310672/3d-vena-contracta-area-after-mitraclip%C3%A2-procedure-precise-quantification-of-residual-mitral-regurgitation-and-identification-of-prognostic-information
#8
Alexander Dietl, Christine Prieschenk, Franziska Eckert, Christoph Birner, Andreas Luchner, Lars S Maier, Stefan Buchner
BACKGROUND: Percutaneous mitral valve repair (PMVR) is increasingly performed in patients with severe mitral regurgitation (MR). Post-procedural MR grading is challenging and an unsettled issue. We hypothesised that the direct planimetry of vena contracta area (VCA) by 3D-transoesophageal echocardiography allows quantifying post-procedural MR and implies further prognostic relevance missed by the usual ordinal scale (grade I-IV). METHODS: Based on a single-centre PMVR registry containing 102 patients, the association of VCA reduction and patients' functional capacity measured as six-minute walk distance (6 MW) was evaluated...
January 9, 2018: Cardiovascular Ultrasound
https://www.readbyqxmd.com/read/29304185/high-body-mass-index-is-a-risk-factor-for-difficult-deep-sedation-in-percutaneous-mitral-valve-repair
#9
Katharina Hellhammer, Shazia Afzal, Renate Tigges, Maximilian Spieker, Tienush Rassaf, Tobias Zeus, Ralf Westenfeld, Malte Kelm, Patrick Horn
BACKGROUND: The safety and efficacy of deep sedation (DS) in MitraClip® procedures have been shown previously. However, clinical experience demonstrates that in some patients DS is difficult to achieve. We hypothesize that some patient characteristics can predict difficult DS. METHODS: We prospectively analysed 69 patients undergoing MitraClip® procedures using DS. Application of DS was graded as simple (group 1) or difficult (group 2) depending on a cumulative score based on one point for each of the following criteria: decrease in oxygen saturation, retention of carbon dioxide, disruptive body movements, and the need for catecholamines...
2018: PloS One
https://www.readbyqxmd.com/read/29208340/different-indicators-for-postprocedural-mitral-stenosis-caused-by-single-or-multiple-clip-implantation-after-percutaneous-mitral-valve-repair
#10
Yuji Itabashi, Hiroto Utsunomiya, Shunsuke Kubo, Yukiko Mizutani, Hirotsugu Mihara, Mitsushige Murata, Robert J Siegel, Saibal Kar, Keiichi Fukuda, Takahiro Shiota
BACKGROUND: Postprocedural mitral stenosis (MS) is a main limitation for MitraClip™ (Abbot Vascular, Inc., Santa Clara, CA, USA) procedure. The purpose of this study was to detect the preprocedural predictors of high transmitral pressure gradient (TMPG) after MitraClip™ implantation, which indicated postprocedural mitral stenosis (MS). METHODS: We studied 79 patients who were implanted with MitraClip™ in our institute. Before the procedure, mitral valve orifice area (MVOA), and anterior-posterior (AP) and medial-lateral (ML) mitral annular diameters were measured at diastole using three-dimensional (3D) transesophageal echocardiography (TEE) data set...
April 2018: Journal of Cardiology
https://www.readbyqxmd.com/read/29204737/initial-slovenian-experience-with-mitraclip-therapy-careful-selection-of-patients-is-crucial-for-optimal-outcome
#11
Jana Ambrožič, Marta Cvijič, Mojca Bervar, Špela Mušič, Matjaž Bunc
BACKGROUND: MitraClip is a percutaneous mitral repair technology increasingly used for high surgical risk patients with primary or secondary mitral regurgitation. We describe initial Slovenian experience with MitraClip and discuss the importance of identifying the suitable candidates for this procedure. METHODS: We retrospectively analyzed the first 10 patients (mean age 75.6 ± 6.9 years, logistic Euroscore 28.4 ± 10.9%) with severe and moderate to severe mitral regurgitation (8 secondary, 1 primary and 1 mixed etiology) who underwent a MitraClip procedure between January 2015 and February 2017...
December 4, 2017: Wiener Klinische Wochenschrift
https://www.readbyqxmd.com/read/29161956/percutaneous-repair-of-mitral-valve-regurgitation-in-patients-with-severe-heart-failure-comparison-with-optimal-medical-treatment
#12
Nicolas Geis, Philip Raake, Markus Lewening, Derliz Mereles, Emmanuel Chorianopoulos, Lutz Frankenstein, Hugo A Katus, Raffi Bekeredjian, Sven T Pleger
BACKGROUND: Occurrence of severe mitral valve (MV) regurgitation (MR) is an independent negative predictor of mortality in patients with severe systolic heart failure (HF). This study examines clinical effects and cardiac reverse remodelling in patients with severe systolic HF receiving percutaneous mitral valve repair (PMVR) using MitraClip in comparison to patients receiving optimal medical therapy only. METHODS: Between 2010 and 2014, 86 patients (Society of Thoracic Surgeons score: 10...
November 21, 2017: Acta Cardiologica
https://www.readbyqxmd.com/read/29152276/percutaneous-mitral-valve-repair-with-the-mitraclip-nt%C3%A2-system-in-a-patient-presenting-with-prolonged-cardiogenic-shock
#13
Dominik Buckert, Sinisa Markovic, Markus Kunze, Jochen Wöhrle, Wolfgang Rottbauer, Daniel Walcher
The MitraClip NT™ system for the treatment of severe mitral valve regurgitation is effective and safe - even for patients suffering from cardiogenic shock. The use of an intra-aortic balloon pump expands the range of possible applications to this particular group of challenging patients.
November 2017: Clinical Case Reports
https://www.readbyqxmd.com/read/29148247/does-the-severity-of-left-ventricular-systolic-dysfunction-impact-outcomes-of-mitraclip-therapy-how-low-is-too-low
#14
EDITORIAL
Mehmet Cilingiroglu, Abdul Hakeem
Percutaneous mitral valve repair for symptomatic severe mitral regurgitation has rapidly evolved as a viable therapeutic option for high-surgical risk patients. Both randomized clinical studies as well as real world registry data have demonstrated significant improvement in severity of MR and clinical outcomes. In carefully selected patients with severely reduced left ventricular systolic function and severe symptomatic MR, Mitraclip therapy seems to show promise.
November 15, 2017: Catheterization and Cardiovascular Interventions
https://www.readbyqxmd.com/read/29148095/vascular-complications-after-percutaneous-mitral-valve-repair-and-venous-access-closure-using-suture-or-closure-device
#15
Birgit Steppich, Felix Stegmüller, Philipp Moritz Rumpf, Jürgen Pache, Carolin Sonne, Hasema Lesevic, Daniel Braun, Jörg Hausleiter, Albert Markus Kasel, Ilka Ott
OBJECTIVE: The aim of this study was to assess the impact of different access-site closure strategies, suture or closure device (Proglide, Abbott Vascular), on vascular and bleeding complications after percutaneous mitral valve repair (MitraClip, Abbott Vascular). BACKGROUND: Considering the high-risk profile in patients receiving percutaneous mitral valve repair, complications related to the large 24 Fr access sheath and its relation to the closure technique have not been evaluated so far...
November 16, 2017: Journal of Interventional Cardiology
https://www.readbyqxmd.com/read/29122275/bleeding-complications-after-percutaneous-mitral-valve-repair-with-the-mitraclip
#16
Maria Isabel Körber, Julia Silwedel, Kai Friedrichs, Victor Mauri, Michael Huntgeburth, Roman Pfister, Stephan Baldus, Volker Rudolph
Bleeding after cardiac surgery or cardiovascular interventions is associated with worse patient outcome. Only very limited data are available on the subject of bleeding after percutaneous edge-to-edge mitral valve repair (PMVR). We performed a single center analysis including 347 consecutive patients who underwent PMVR. Bleeding was defined according to the Mitral Valve Academic Research Consortium (MVARC) end point definition. The incidence of MVARC bleeding was 21.6% (n = 75), whereas major MVARC bleeding (hemoglobin decrease ≥3 g/dl) occurred in 7...
January 1, 2018: American Journal of Cardiology
https://www.readbyqxmd.com/read/29113720/spanish-cardiac-catheterization-and-coronary-intervention-registry-26th-official-report-of-the-spanish-society-of-cardiology-working-group-on-cardiac-catheterization-and-interventional-cardiology-1990-2016
#17
Ana María Serrador Frutos, Pilar Jiménez-Quevedo, Armando Pérez de Prado, Manuel Pan Álvarez-Ossorio
INTRODUCTION AND OBJECTIVES: The Working Group on Cardiac Catheterization and Interventional Cardiology presents its annual report on the activity data for 2016. METHODS: All Spanish hospitals with catheterization laboratories were invited to voluntarily contribute their activity data. The information was collected online and was analyzed mainly by an independent company. RESULTS: In 2016, 106 centers participated in the national registry; 80 of these centers are public...
December 2017: Revista Española de Cardiología
https://www.readbyqxmd.com/read/29033048/comparison-of-outcome-after-percutaneous-mitral-valve-repair-with-the-mitraclip-in-patients-with-versus-without-atrial-fibrillation
#18
MULTICENTER STUDY
Juliëtte F Velu, Friso A Kortlandt, Tom Hendriks, Remco A J Schurer, Ad J van Boven, Karel T Koch, M Marije Vis, Jose P Henriques, Jan J Piek, Ben J L Van den Branden, Jeroen Schaap, Benno J Rensing, Martin J Swaans, Berto J Bouma, Jan A S Van der Heyden, Jan Baan
Percutaneous mitral valve repair with the MitraClip is an established treatment for patients with mitral regurgitation (MR) who are inoperable or at high risk for surgery. Atrial Fibrillation (AF) frequently coincides with MR, but only scarce data of the influence of AF on outcome after MitraClip is available. The aim of the current study was to compare the clinical outcome after MitraClip treatment in patients with versus without atrial fibrillation. Between January 2009 and January 2016, all consecutive patients treated with a MitraClip in 5 Dutch centers were included...
December 1, 2017: American Journal of Cardiology
https://www.readbyqxmd.com/read/29032936/editorial-commentary-percutaneous-edge-to-edge-mitral-valve-repair-with-mitraclip-state-of-the-art-and-new-perspectives
#19
EDITORIAL
Flavia Ballocca
No abstract text is available yet for this article.
September 28, 2017: Trends in Cardiovascular Medicine
https://www.readbyqxmd.com/read/29027267/percutaneous-repair-of-severe-mitral-valve-regurgitation-secondary-to-chordae-rupture-in-octogenarians-using-mitraclip
#20
Nicolas Geis, Philip Raake, Derliz Mereles, Emmanuel Chorianopoulos, Gabor Szabo, Hugo A Katus, Raffi Bekeredjian, Sven T Pleger
OBJECTIVES: The aim of this study was to assess feasibility and clinical effectiveness of the MitraClip device in octogenarians suffering from severe mitral valve regurgitation due to chordae rupture. BACKGROUND: The MitraClip procedure is a suitable technique in high-risk surgical patients to achieve safe and effective percutaneous repair of mitral valve regurgitation. Octogenarians show cumulative risk and social aspects hindering mitral valve surgery. No data exists regarding the use of the MitraClip device in high-risk octogenarians suffering from mitral valve chordae rupture...
October 12, 2017: Journal of Interventional Cardiology
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