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https://www.readbyqxmd.com/read/28944711/a-hybrid-composite-system-of-biphasic-calcium-phosphate-granules-loaded-with-hyaluronic-acid-gelatin-hydrogel-for-bone-regeneration
#1
Omar Faruq, Boram Kim, Andrew R Padalhin, Gun Hee Lee, Byong-Taek Lee
An ideal bone substitute should be made of biocompatible materials that mimic the structure, characteristics, and functions of natural bone. Many researchers have worked on the fabrication of different bone scaffold systems including ceramic-polymer hybrid system. In the present study, we incorporated hyaluronic acid-gelatin hydrogel to micro-channeled biphasic calcium phosphate granules as a carrier to improve cell attachment and proliferation through highly interconnected porous structure. This hybrid system is composed of ceramic biphasic calcium phosphate granules measuring 1 mm in diameter with seven holes and hyaluronic acid-gelatin hydrogel...
January 1, 2017: Journal of Biomaterials Applications
https://www.readbyqxmd.com/read/28941304/collagen-agarose-alginate-and-matrigel-hydrogels-as-cell-substrates-for-culture-of-chondrocytes-in-vitro-a-comparative-study
#2
Zhikang Miao, Zhenhui Lu, Huayu Wu, Hui Liu, Muyan Li, Danqing Lei, Li Zheng, Jinmin Zhao
Autologous chondrocyte implantation (ACI) has emerged as a new approach to cartilage repair through the use of harvested chondrocytes. But the expansion of the chondrocytes from the donor tissue in vitro is restricted by limited cell numbers and dedifferentiation of chondrocytes. In this study, we used four types of hydrogels including agarose, alginate, Matrigel and collagen type I hydrogels to serve as cell substrates and investigated the effect on proliferation and phenotype maintenance of chondrocytes. As a substrate for monolayer culture, collagen facilitated cell expansion and effectively suppressed the dedifferentiation of chondrocytes, as evidenced by fluorescein diacetate / propidium iodide (FDA/PI), hematoxylin-eosin staining (HE), Safranin O, immunofluorescenceassay, biochemistry analysis and quantitative real-time polymerase chain reaction (qRT-PCR)...
September 23, 2017: Journal of Cellular Biochemistry
https://www.readbyqxmd.com/read/28940819/vacancy-driven-gelation-using-defect-rich-nanoassemblies-of-2d-transition-metal-dichalcogenides-and-polymeric-binder-for-biomedical-applications
#3
Manish K Jaiswal, James K Carrow, James L Gentry, Jagriti Gupta, Nara Altangerel, Marlan Scully, Akhilesh K Gaharwar
A new approach of vacancy-driven gelation to obtain chemically crosslinked hydrogels from defect-rich 2D molybdenum disulfide (MoS2 ) nanoassemblies and polymeric binder is reported. This approach utilizes the planar and edge atomic defects available on the surface of the 2D MoS2 nanoassemblies to form mechanically resilient and elastomeric nanocomposite hydrogels. The atomic defects present on the lattice plane of 2D MoS2 nanoassemblies are due to atomic vacancies and can act as an active center for vacancy-driven gelation with a thiol-activated terminal such as four-arm poly(ethylene glycol)-thiol (PEG-SH) via chemisorption...
September 2017: Advanced Materials
https://www.readbyqxmd.com/read/28934875/natural-type-ii-collagen-hydrogel-fibrin-sealant-and-adipose-derived-stem-cells-as-a-promising-combination-for-articular-cartilage-repair
#4
Mariana Lazarini, Pedro Bordeaux-Rego, Renata Giardini-Rosa, Adriana S S Duarte, Mariana Ozello Baratti, Alessandro Rozim Zorzi, João Batista de Miranda, Carlos Lenz Cesar, Ângela Luzo, Sara Teresinha Olalla Saad
Objective Articular cartilage is an avascular tissue with limited ability of self-regeneration and the current clinical treatments have restricted capacity to restore damages induced by trauma or diseases. Therefore, new techniques are being tested for cartilage repair, using scaffolds and/or stem cells. Although type II collagen hydrogel, fibrin sealant, and adipose-derived stem cells (ASCs) represent suitable alternatives for cartilage formation, their combination has not yet been investigated in vivo for focal articular cartilage defects...
October 2017: Cartilage
https://www.readbyqxmd.com/read/28931970/toward-a-versatile-toolbox-for-cucurbit-n-uril-based-supramolecular-hydrogel-networks-through-in-situ-polymerization
#5
Ji Liu, Cindy Soo Yun Tan, Yang Lan, Oren A Scherman
The success of exploiting cucurbit[n]uril (CB[n])-based molecular recognition in self-assembled systems has sparked a tremendous interest in polymer and materials chemistry. In this study, polymerization in the presence of host-guest complexes is applied as a modular synthetic approach toward a diverse set of CB[8]-based supramolecular hydrogels with desirable properties, such as mechanical strength, toughness, energy dissipation, self-healing, and shear-thinning. A range of vinyl monomers, including acrylamide-, acrylate-, and imidazolium-based hydrophilic monomers, could be easily incorporated as the polymer backbones, leading to a library of CB[8] hydrogel networks...
September 15, 2017: Journal of Polymer Science. Part A, Polymer Chemistry
https://www.readbyqxmd.com/read/28930451/a-biomimetic-stress-sensitive-hydrogel-controlled-by-dna-nanoswitches
#6
Swapneel R Deshpande, Roel Hammink, Frank H T Nelissen, Alan E Rowan, Hans A Heus
One of the most intriguing and important aspects of biological supramolecular materials is its ability to adapt macroscopic properties in response to environmental cues for controlling cellular processes. Recently, bulk matrix stiffness, in particular stress sensitivity, has been established as a key mechanical cue in cellular function and development. However, stress-stiffening capacity and the ability to control and exploit this key characteristic is relatively new to the field of biomimetic materials. In this work, DNA-responsive hydrogels, composed of semiflexible PIC polymers equipped with DNA cross-linkers, were engineered to create mimics of natural biopolymer networks that capture these essential elastic properties and can be controlled by external stimuli...
September 20, 2017: Biomacromolecules
https://www.readbyqxmd.com/read/28927932/chitosan-doxycycline-hydrogel-an-mmp-inhibitor-sclerosing-embolizing-agent-as-a-new-approach-to-endoleak-prevention-and-treatment-after-endovascular-aneurysm-repair
#7
Fatemeh Zehtabi, Pompilia Ispas-Szabo, Djahida Djerir, Lojan Sivakumaran, Borhane Annabi, Gilles Soulez, Mircea Alexandru Mateescu, Sophie Lerouge
The success of endovascular repair of abdominal aortic aneurysms remains limited due to the development of endoleaks. Sac embolization has been proposed to manage endoleaks, but current embolizing materials are associated with frequent recurrence. An injectable agent that combines vascular occlusion and sclerosing properties has demonstrated promise for the treatment of endoleaks. Moreover, the inhibition of aneurysmal wall degradation via matrix metalloproteinases (MMPs) may further prevent aneurysm progression...
September 16, 2017: Acta Biomaterialia
https://www.readbyqxmd.com/read/28925684/carbon-nanotube-based-ion-selective-sensors-for-wearable-applications
#8
Soumyendu Roy, Moshe David-Pur, Yael Hanein
Wearable electronics offer new opportunities in a wide range of applications, especially sweat analysis using skin sensors. A fundamental challenge in these applications is the formation of sensitive and stable electrodes. In this article we report the development of a wearable sensor based on carbon nanotube (CNT) electrode arrays for sweat sensing. Solid-state ion selective electrodes (ISEs), sensitive to Na+ ions, were prepared by drop coating plasticized poly-vinyl chloride (PVC) doped with ionophore and ion exchanger on CNT electrodes...
September 19, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28923973/flow-induced-gelation-of-microfiber-suspensions
#9
Antonio Perazzo, Janine K Nunes, Stefano Guido, Howard A Stone
The flow behavior of fiber suspensions has been studied extensively, especially in the limit of dilute concentrations and rigid fibers; at the other extreme, however, where the suspensions are concentrated and the fibers are highly flexible, much less is understood about the flow properties. We use a microfluidic method to produce uniform concentrated suspensions of high aspect ratio, flexible microfibers, and we demonstrate the shear thickening and gelling behavior of such microfiber suspensions, which, to the best of our knowledge, has not been reported previously...
September 18, 2017: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/28917901/polysaccharides-based-injectable-hydrogel-compositing-bio-glass-for-cranial-bone-repair
#10
Xiao Bai, Shaoyu Lü, Haidi Liu, Zhen Cao, Piao Ning, Zengqiang Wang, Chunmei Gao, Boli Ni, Dongyang Ma, Mingzhu Liu
Bone disease is a public health problem around the word, and it is urgent to develop novel tissue engineering scaffolds for the complicated cranial bone regeneration. The present work developed a novel triple crosslinked polysaccharides based injectable hydrogel to composite bio-glass (BG) for cranial bone repair. Dynamic mechanical analysis showed the storage modulus (G') of the hydrogel reached to ∼4000Pa. While after compositing BG, G' exceeded 4500Pa. The degradation behavior of the hydrogel is influenced by hydrogel composition, crosslinking methods and degradation environment...
November 1, 2017: Carbohydrate Polymers
https://www.readbyqxmd.com/read/28917879/laccase-tempo-oxidation-in-the-production-of-mechanically-strong-arabinoxylan-and-glucomannan-aerogels
#11
Kirsti Parikka, Ida Nikkilä, Leena Pitkänen, Abdul Ghafar, Tuula Sontag-Strohm, Maija Tenkanen
New wheat arabinoxylan and konjac glucomannan hydrogels and aerogels were prepared by hemiacetal crosslinking induced by laccase/TEMPO (2,2,6,6-tetramethylpiperidine-1-oxyl) -catalysed oxidation, which selectively converts the primary hydroxyl groups to aldehydes. The degree of oxidation of the product aldehydes was ca. 10% of the total carbohydrates of the polysaccharides, and the determination of storage and viscous moduli of the oxidised samples showed that they had formed true hydrogels. Two freezing methods for the hydrogels, conventional freezing and ice crystal templating, were investigated for aerogel production, the ice crystal templated products especially were mechanically strong in compression test against the ice crystals' growth direction...
November 1, 2017: Carbohydrate Polymers
https://www.readbyqxmd.com/read/28902202/responsive-photonic-barcodes-for-sensitive-multiplex-bioassay
#12
Chengxin Luan, Yueshuang Xu, Fanfan Fu, Huan Wang, Qionghua Xu, Baoan Chen, Yuanjin Zhao
Barcodes have a demonstrated value for multiplex high-throughput bioassays. The tendency of this technology is to pursue high sensitivity target screening. Herein, we presented a new type of inverse opal-structured poly(N-isopropylacrylamide) (pNIPAM) hydrogel photonic crystal (PhC) barcodes with the function of fluorescent signal self-amplification for the detection. During the bio-reaction process at body temperature, the pNIPAM hydrogel barcodes kept swelling, and their inverse opal structure with interconnected pores provided unblocked channels for the targets to diffuse into the voids of the barcodes and react...
September 13, 2017: Nanoscale
https://www.readbyqxmd.com/read/28895627/-vitreous-substitute-in-retinal-detachment-surgery-why-we-need-a-new-tamponade-strategy
#13
Peter Szurman
Pars plana vitrectomy combined with an endotamponade is the most important concept in retinal detachment surgery. Numerous advances in techniques and tamponade materials have been made, but the general problems of retinal detachment surgery are still unsolved: The primary success rate is not adequate, and there is no adequate strategy to address proliferative vitreoretinopathy, multiple retinal breaks or persistent hypotony. The story of tamponades is full of myths and misunderstandings. A critical review shows that tamponades have only a minor role in the history of retinal detachment surgery...
September 2017: Klinische Monatsblätter Für Augenheilkunde
https://www.readbyqxmd.com/read/28894668/mucosal-perfusion-preservation-by-a-novel-shapeable-tissue-expander-for-oral-reconstruction
#14
Daria Barwinska, John Garner, Darrell D Davidson, Todd G Cook, George J Eckert, Sunil S Tholpady, Keith L March, Kinam Park, Clark T Barco
BACKGROUND: There are few methods for expanding oral mucosa, and these often cause complications such as tissue necrosis and expander eruption. This study examines mucosal blood perfusion following insertion of a novel shapeable hydrogel tissue expander (HTE). The canine model used subgingival insertion of HTE following tooth extraction and alveolar bone reduction. The primary goal of this study was to gain understanding of epithelial perfusion and reparative responses of gingival mucosa during HTE expansion...
August 2017: Plastic and Reconstructive Surgery. Global Open
https://www.readbyqxmd.com/read/28888978/fabrication-of-drug-loaded-hydrogels-with-stereolithographic-3d-printing
#15
Pamela Robles Martinez, Alvaro Goyanes, Abdul W Basit, Simon Gaisford
3D printing (3DP) technologies have been attracting much recent interest as new methods of fabricating medicines and medical devices. Of the many types of 3DP available, stereolithographic (SLA) printing offers the unique advantage of being able to fabricate objects by cross-linking resins to form networked polymer matrices. Because water can be entrapped in these matrices, it is possible in principle to fabricate pre-wetted, drug-loaded hydrogels and devices. Here, SLA printing was used to prepare ibuprofen-loaded hydrogels of cross-linked polyethylene glycol diacrylate...
September 6, 2017: International Journal of Pharmaceutics
https://www.readbyqxmd.com/read/28888476/computational-sensitivity-investigation-of-hydrogel-injection-characteristics-for-myocardial-support
#16
Hua Wang, Christopher B Rodell, Madonna E Lee, Neville N Dusaj, Joseph H Gorman, Jason A Burdick, Robert C Gorman, Jonathan F Wenk
Biomaterial injection is a potential new therapy for augmenting ventricular mechanics after myocardial infarction (MI). Recent in vivo studies have demonstrated that hydrogel injections can mitigate the adverse remodeling due to MI. More importantly, the material properties of these injections influence the efficacy of the therapy. The goal of the current study is to explore the interrelated effects of injection stiffness and injection volume on diastolic ventricular wall stress and thickness. To achieve this, finite element models were constructed with different hydrogel injection volumes (150µL and 300 µL), where the modulus was assessed over a range of 0...
September 1, 2017: Journal of Biomechanics
https://www.readbyqxmd.com/read/28888014/development-and-evaluation-of-thymol-chitosan-hydrogels-with-antimicrobial-antioxidant-activity-for-oral-local-delivery
#17
María Inés Alvarez Echazú, Christian Ezequiel Olivetti, Claudia Anesini, Claudio Javier Perez, Gisela Solange Alvarez, Martin Federico Desimone
Nowadays, the research of innovative drug delivery devices is focused on the design of multiple drug delivery systems, the prevention of drug side effects and the reduction of dosing intervals. Particularly, new mucosal delivery systems for antimicrobials, antioxidants and anti-inflammatory drugs has a growing development, regards to the avoidance of side effects, easy administration and a suitable drug concentration in the mucosa. In this work, chitosan hydrogels are evaluated as a biodegradable scaffold and as a bioactive agent carrier of an antioxidant-antimicrobial compound called thymol...
December 1, 2017: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/28887638/a-new-strategy-to-sustained-release-of-ocular-drugs-by-one-step-drug-loaded-microcapsule-manufacturing-in-hydrogel-punctal-plugs
#18
Jiajun Xie, Changjun Wang, Qingyao Ning, Qi Gao, Changyou Gao, Zhongru Gou, Juan Ye
PURPOSE: To design an injectable hyaluronate (HA)-based hydrogel system that contains drug-loaded microcapsules as resorbable plugs to deliver ocular drugs. METHODS: In-situ drug-loaded, core-shell-structured chitosan (CS)@HA microcapsules were fabricated via HA hydrosol collecting in electrospun bead-rich CS fibers under continuous stirring. An injectable and cytocompatible hydrogel system with different degrees of chemical crosslinking maintained viscoelastic and sustained drug release for a long-term period of time at body temperature in vitro...
September 8, 2017: Graefe's Archive for Clinical and Experimental Ophthalmology
https://www.readbyqxmd.com/read/28885839/co2-stimuli-responsive-injectable-block-copolymer-hydrogels-cross-linked-by-discrete-organoplatinum-ii-metallacycles-via-stepwise-post-assembly-polymerization
#19
Wei Zheng, Guang Yang, Nannan Shao, Li-Jun Chen, Bo Ou, Shu-Ting Jiang, Guosong Chen, Hai-Bo Yang
Supramolecular polymeric gels cross-linked by well-defined, discrete metal-organic macrocycles (MOMs) or metal-organic cages have become a prevailing topic within the field of supramolecular self-assembly. However, the realization of supramolecular polymeric hydrogels cross-linked by discrete organometallic architectures with good biocompatibility is still a great challenge. Herein, we present the successful preparation of CO2 stimuli-responsive, injectable block copolymer hydrogels cross-linked by discrete organoplatinum(II) metallacycles...
September 20, 2017: Journal of the American Chemical Society
https://www.readbyqxmd.com/read/28876895/3d-printing-of-photocurable-cellulose-nanocrystal-composite-for-fabrication-of-complex-architectures-via-stereolithography
#20
Napolabel Palaganas, Joey Mangadlao, Al Christopher De Leon, Jerome Palaganas, Katrina Pangilinan, Yan Jie Lee, Rigoberto Advincula
The advantages of 3D printing on cost, speed, accuracy, and flexibility have attracted several new applications in various industries especially in the field of medicine where customized solutions are highly demanded. Although this modern fabrication technique offers several benefits, it also poses critical challenges in materials development suitable for industry use. Proliferation of polymers in biomedical application has been severely limited by their inherently weak mechanical properties despite their other excellent attributes...
September 6, 2017: ACS Applied Materials & Interfaces
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