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https://www.readbyqxmd.com/read/28228933/vascularization-and-innervation-of-slits-within-polydimethylsiloxane-sheets-in-the-subcutaneous-space-of-athymic-nude-mice
#1
Rachel E Gurlin, Mark T Keating, Shiri Li, Jonathan Rt Lakey, Sébastien de Feraudy, Bhupinder S Shergill, Elliot L Botvinick
Success of cell therapy in avascular sites will depend on providing sufficient blood supply to transplanted tissues. A popular strategy of providing blood supply is to embed cells within a functionalized hydrogel implanted within the host to stimulate neovascularization. However, hydrogel systems are not always amenable for removal post-transplantation; thus, it may be advantageous to implant a device that contains cells while also providing access to the circulation so retrieval is possible. Here we investigate one instance of providing access to a vessel network, a thin sheet with through-cut slits, and determine if it can be vascularized from autologous materials...
January 2017: Journal of Tissue Engineering
https://www.readbyqxmd.com/read/28226459/a-simple-method-for-micropatterning-nanofibrous-hydrogel-film
#2
K Higashi, N Miki, K Higashi, N Miki, K Higashi, N Miki
This paper propose a new fabrication process for micropatterning a nanofibrous thin film made of bacterial cellulose(BC). BC is a hydrogel produced by specific bacteria and composed of pure cellulosic nanoflbers exhibiting 3D network structure. Such nanofibrous structure is found to be appropriate for adhesion of anchorage-dependent cells. Furthermore, BC shows high biocompatibility and mechanical toughness. Thus, the microfabrication technique for BC broadens potentials for applications. In this study, we report a new method for micropatterning BC film with feature resolution comparable with photolithography technology...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28226456/hydrogel-reinforced-polypyrrole-electroactuator
#3
Yongchen Wang, Bingxi Yan, Yu Wu, Liang Guo, Yongchen Wang, Bingxi Yan, Yu Wu, Liang Guo, Yongchen Wang, Liang Guo, Bingxi Yan, Yu Wu
Robust electroactuators that are lightweight, power-efficient and capable of generating high forces at a low actuation voltage are of great demand in the design of micro-electromechanical systems (MEMS) for biomedical applications. In this work, electroactive composite films of alginate hydrogel and polypyrrole/polyethylene glycol (PPy/PEG) are synthesized and characterized as actuators for driving an implantable insulin micropump. A porous and flexible alginate hydrogel back layer is used to mechanically reinforce the PPy/PEG film by enhancing the actuator's resistance to its generated tension but without increase of its overall rigidness...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28221748/fe3-ph-thermo-responsive-supramolecular-hydrogel-with-multi-shape-memory-effect
#4
Xiaoxia Le, Wei Lu, He Xiao, Li Wang, Chunxin Ma, Jiawei Zhang, Youju Huang, Tao Chen
Poor, non-tunable mechanical properties as well as finite shape memory performance pose a barrier to shape memory hydrogels to realize practical applications. Here, a new shape memory hydrogel with tunable mechanical properties and multi-shape memory effect was presented. Three programmable reversible systems including PBA-diol ester bonds, AAc-Fe3+ and coil-helix transition of agar were applied to memorize temporary shapes and endow the hydrogel with outstanding multi-shape memory functionalities. Moreover, through changing the crosslinking densities, the mechanical properties of the as-prepared hydrogel can be adjusted...
February 21, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28221713/reconfigurable-microscale-frameworks-from-concatenated-helices-with-controlled-chirality
#5
Seog-Jin Jeon, Ryan C Hayward
The utility of helical structures in driving motion of microorganisms and plants has inspired efforts to develop synthetic stimuli-responsive helical architectures for self-motile and shape-morphing systems. While several approaches to responsive helices based on hydrogels and liquid crystalline polymers have been reported, they have so far been limited to macroscopic (cm scale) dimensions, and have not been applied to concatenated helices with more than two segments. Here, a robust method for microfabrication of helices inspired by Bauhinia seedpods, based on trilayer samples consisting of rigid plastic stripes sandwiching a swellable temperature-responsive hydrogel, is reported and the formation of responsive shape-controlled frameworks from concatenated multiple helices (multihelices) with controlled chirality is demonstrated...
February 21, 2017: Advanced Materials
https://www.readbyqxmd.com/read/28220175/a-mechanically-robust-hydrogel-with-thermally-induced-plasticity-and-a-shape-memory-effect
#6
Kang Peng, Hansen Yu, Haiyang Yang, Xiang Hao, Akram Yasin, Xingyuan Zhang
A new class of smart structural hydrogels is prepared by introducing dual cross-linkers into a single-network system. The present hydrogel, on the one hand, exhibits excellent mechanical properties; on the other hand, it exhibits thermally induced plasticity and a shape memory effect without any overlap.
February 21, 2017: Soft Matter
https://www.readbyqxmd.com/read/28216297/high-water-content-and-resilient-peg-containing-hydrogels-with-low-fibrotic-response
#7
Yu Zhang, Duo An, Yehudah Pardo, Alan Chiu, Wei Song, Qingsheng Liu, Fang Zhou, Sean P McDonough, Minglin Ma
: Hydrogels such as those based on polyethylene glycol (PEG) are broadly used in biomedicine where high water contents, robust mechanical properties such as resilience and favorable interactions with the body are often simultaneously desirable. However, the mechanical properties of conventional hydrogels often degrade rapidly after swelling or with increasing water content, limiting their potential in many applications. Here we describe a new class of PEG-containing hydrogels that remain highly resilient after maximum swelling...
February 16, 2017: Acta Biomaterialia
https://www.readbyqxmd.com/read/28212637/a-pectin-honey-hydrogel-prevents-postoperative-intraperitoneal-adhesions-in-a-rat-model
#8
Gessica Giusto, Cristina Vercelli, Selina Iussich, Andrea Audisio, Emanuela Morello, Rosangela Odore, Marco Gandini
BACKGROUND: Adhesions are a common postoperative surgical complication. Liquid honey has been used intraperitoneally to reduce the incidence of these adhesions. However, solid barriers are considered more effective than liquids in decreasing postoperative intra-abdominal adhesion formation; therefore, a new pectin-honey hydrogel (PHH) was produced and its effectiveness was evaluated in a rat cecal abrasion model. Standardized cecal/peritoneal abrasion was performed through laparotomy in 48 adult Sprague-Dawley rats to induce peritoneal adhesion formation...
February 17, 2017: BMC Veterinary Research
https://www.readbyqxmd.com/read/28208029/l1-peptide-conjugated-fibrin-hydrogels-promote-salivary-gland-regeneration
#9
K Nam, C-S Wang, C L M Maruyama, P Lei, S T Andreadis, O J Baker
Hyposalivation contributes to dental caries, periodontitis, and microbial infections. Additionally, it impairs activities of daily living (e.g., speaking, chewing, and swallowing). Treatments for hyposalivation are currently limited to medications (e.g., the muscarinic receptor agonists pilocarpine and cevimeline) that induce saliva secretion from residual acinar cells and the use of saliva substitutes. However, given that these therapies provide only temporary relief, the development of alternative treatments to restore gland function is essential...
February 1, 2017: Journal of Dental Research
https://www.readbyqxmd.com/read/28207179/self-assembled-liquid-crystalline-membranes-form-supramolecular-hydrogels-via-hydrogen-bonding
#10
Youfeng Yue
Developing simple methods to organize nanoscale building blocks into ordered superstructures is a crucial step toward the practical development of nanotechnology. Bottom-up nanotechnology using self-assembly bridges the molecular and macroscopic, and can provide unique material properties, different from the isotropic characteristics of common substances. In this study, a new class of supramolecular hydrogels comprising 40 nm thick linear polymer layers sandwiched between nanolayers of self-assembled amphiphilic molecules are prepared and studied by nuclear magnetic resonance spectroscopy, scanning electronic microscopy, small angle X-ray diffraction, and rheometry...
February 16, 2017: Macromolecular Rapid Communications
https://www.readbyqxmd.com/read/28202725/stretchable-living-materials-and-devices-with-hydrogel-elastomer-hybrids-hosting-programmed-cells
#11
Xinyue Liu, Tzu-Chieh Tang, Eléonore Tham, Hyunwoo Yuk, Shaoting Lin, Timothy K Lu, Xuanhe Zhao
Living systems, such as bacteria, yeasts, and mammalian cells, can be genetically programmed with synthetic circuits that execute sensing, computing, memory, and response functions. Integrating these functional living components into materials and devices will provide powerful tools for scientific research and enable new technological applications. However, it has been a grand challenge to maintain the viability, functionality, and safety of living components in freestanding materials and devices, which frequently undergo deformations during applications...
February 15, 2017: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/28198736/we-can-see-clearly-now-optical-clearing-and-kidney-morphometrics
#12
Victor G Puelles, Marcus J Moeller, John F Bertram
PURPOSE OF REVIEW: For more than a century, kidney microscopic imaging was driven by the need for greater and greater resolution. This was in part provided by the analysis of thinner tissue sections. As a result, most kidney morphometry was performed in 'two' dimensions, largely ignoring the three-dimensionality of kidney tissue and cells. Although stereological techniques address this issue, they have generally been considered laborious and expensive and thereby unattractive for routine use...
February 13, 2017: Current Opinion in Nephrology and Hypertension
https://www.readbyqxmd.com/read/28198591/interpenetrating-conducting-hydrogel-materials-for-neural-interfacing-electrodes
#13
Josef Goding, Aaron Gilmour, Penny Martens, Laura Poole-Warren, Rylie Green
Conducting hydrogels (CHs) are an emerging technology in the field of medical electrodes and brain-machine interfaces. The greatest challenge to the fabrication of CH electrodes is the hybridization of dissimilar polymers (conductive polymer and hydrogel) to ensure the formation of interpenetrating polymer networks (IPN) required to achieve both soft and electroactive materials. A new hydrogel system is developed that enables tailored placement of covalently immobilized dopant groups within the hydrogel matrix...
February 15, 2017: Advanced Healthcare Materials
https://www.readbyqxmd.com/read/28194388/in-vivo-evaluation-of-porous-hydrogel-pins-to-fill-osteochondral-defects-in-rabbits
#14
Túlio Pereira Cardoso, André Petry Sandoval Ursolino, Pamela de Melo Casagrande, Edie Benedito Caetano, Daniel Vinicius Mistura, Eliana Aparecida de Rezende Duek
OBJECTIVE: This experimental study aimed to evaluate the biological performance of poly (l-co-D, l-lactic acid)-co-trimetilene carbonate/poly (vinyl alcohol) (PLDLA-co TMC/PVA), hydrogel scaffolds, as an implant in the filling (and not in the repair) of osteochondral defects in New Zealand rabbits, assessing the influence of the material in tissue protection in vivo. METHODS: Twelve rabbits were divided into groups of nine and 16 weeks. In each animal, an osteochondral defect was created in both medial femoral condyles...
January 2017: Revista Brasileira de Ortopedia
https://www.readbyqxmd.com/read/28192772/direct-3d-bioprinting-of-prevascularized-tissue-constructs-with-complex-microarchitecture
#15
Wei Zhu, Xin Qu, Jie Zhu, Xuanyi Ma, Sherrina Patel, Justin Liu, Pengrui Wang, Cheuk Sun Edwin Lai, Maling Gou, Yang Xu, Kang Zhang, Shaochen Chen
Living tissues rely heavily on vascular networks to transport nutrients, oxygen and metabolic waste. However, there still remains a need for a simple and efficient approach to engineer vascularized tissues. Here, we created prevascularized tissues with complex three-dimensional (3D) microarchitectures using a rapid bioprinting method - microscale continuous optical bioprinting (μCOB). Multiple cell types mimicking the native vascular cell composition were encapsulated directly into hydrogels with precisely controlled distribution without the need of sacrificial materials or perfusion...
February 2, 2017: Biomaterials
https://www.readbyqxmd.com/read/28192670/metal-ion-mediated-cellulose-nanofibrils-transient-network-in-covalently-cross-linked-hydrogels-mechanistic-insight-into-morphology-and-dynamics
#16
Jun Yang, Feng Xu, Chun-Rui Han
Utilization of reversible interactions as sacrificial bonds in biopolymers is critical for the integral synthesis of mechanically superior biological materials. In this work, cellulose nanofibrils (CNFs) reinforced covalent polyacrylamide (PAAm) composite hydrogels are immersed into multivalent cation (Ca2+, Zn2+, Al3+, and Ce3+) aqueous solution to form ionic association among CNFs, leading to the ionic-covalent cross-linked hydrogels. The cations promote the formation of porous networks of nanofibrils by screening the repulsive negative charges on CNF surface and dominate the mechanical properties and self-recovery efficiency of the hydrogels, resulting in mechanically reinforced ionic hydrogels with stiff (Young's modulus 257 kPa) and tough properties (fracture toughness 386 kJ/m3)...
February 13, 2017: Biomacromolecules
https://www.readbyqxmd.com/read/28187512/a-review-of-gradient-stiffness-hydrogels-used-in-tissue-engineering-and-regenerative-medicine
#17
REVIEW
Xia Tingting, Liu Wanqian, Yang Li
Substrate stiffness is known to impact characteristics including cell differentiation, proliferation, migration and apoptosis. Hydrogels are polymeric materials distinguished by high water content and diverse physical properties. Gradient stiffness hydrogels are designed by the need to develop biologically friendly materials as extracellular matrix (ECM) alternatives to replace the separated and narrow-ranged hydrogel substrates. Important new discoveries in cell behaviors have been realized with model gradient stiffness hydrogel systems from the two-dimensional (2D) to three-dimensional (3D) scale...
February 10, 2017: Journal of Biomedical Materials Research. Part A
https://www.readbyqxmd.com/read/28186211/controlling-the-network-type-in-self-assembled-dipeptide-hydrogels
#18
Catherine Colquhoun, Emily R Draper, Ralf Schweins, Marco Marcello, Devkee Vadukul, Louise C Serpell, Dave J Adams
We show that the same low molecular weight gelator can form gels using three different methods. Gels were formed from a high pH solution either by adding a salt or by adding an acid; gels were also formed by adding water to a solution of the gelator in an organic solvent. The mechanical properties for the gels formed by the different methods are different from one another. We link this to the network type that is formed, as well as the fibrous structures that are formed. The salt-triggered gels show a significant number of fibres that tend to align...
February 10, 2017: Soft Matter
https://www.readbyqxmd.com/read/28181831/basic-concepts-and-recent-advances-in-nanogels-as-carriers-for-medical-applications
#19
Iordana Neamtu, Alina Gabriela Rusu, Alina Diaconu, Loredana Elena Nita, Aurica P Chiriac
Nanogels in biomedical field are promising and innovative materials as dispersions of hydrogel nanoparticles based on crosslinked polymeric networks that have been called as next generation drug delivery systems due to their relatively high drug encapsulation capacity, uniformity, tunable size, ease of preparation, minimal toxicity, stability in the presence of serum, and stimuli responsiveness. Nanogels show a great potential in chemotherapy, diagnosis, organ targeting and delivery of bioactive substances...
November 2017: Drug Delivery
https://www.readbyqxmd.com/read/28177577/lymph-node-stiffness-mimicking-hydrogels-regulate-human-b-cell-lymphoma-growth-and-cell-surface-receptor-expression-in-a-molecular-subtype-specific-manner
#20
Fnu Apoorva, Ye F Tian, Timothy M Pierpont, David M Bassen, Leandro Cerchietti, Jonathan T Butcher, Robert S Weiss, Ankur Singh
Diffuse large B cell lymphoma (DLBCL) is the most common type of non-Hodgkin's lymphoma, with multiple molecular subtypes. The activated B cell-like DLBCL subtype accounts for roughly one-third of all the cases and has an inferior prognosis. There is a need to develop better class of therapeutics that could target molecular pathways in resistant DLBCLs; however this requires DLBCLs to be studied in representative tumor microenvironments. The pathogenesis and progression of lymphoma has been mostly studied from the point of view of genetic alterations and intracellular pathway dysregulation...
February 8, 2017: Journal of Biomedical Materials Research. Part A
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