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https://www.readbyqxmd.com/read/27920897/impact-of-biopolymer-matrices-on-relaxometric-properties-of-contrast-agents
#1
Alfonso Maria Ponsiglione, Maria Russo, Paolo Antonio Netti, Enza Torino
Properties of water molecules at the interface between contrast agents (CAs) for magnetic resonance imaging and macromolecules could have a valuable impact on the effectiveness of metal chelates. Recent studies, indeed, demonstrated that polymer architectures could influence CAs' relaxivity by modifying the correlation times of the metal chelate. However, an understanding of the physico-chemical properties of polymer/CA systems is necessary to improve the efficiency of clinically used CAs, still exhibiting low relaxivity...
December 6, 2016: Interface Focus
https://www.readbyqxmd.com/read/27919214/hydrogel-based-drug-delivery-systems-a-review-with-special-emphasis-on-challenges-associated-with-decontamination-of-hydrogels-and-biomaterials
#2
Irene Satiko Kikuchi, Raquel Galante, Kamal Dua, Daniela Dal Molim Ghisleni, Terezinha de Jesus Andreoli Pinto, Venkata Ramana Malipeddi, Rajendra Awasthi
Many researches involving the development of new techniques and biomaterials to formulate a suitable drug delivery systems and tissue engineering have been conducted. The majority of published literature from these researches emphasizes the production and materials characterization. However there is very limited information regarding their sterilization methods. The present review article has summarized various different literatures that encompasses the difficulties encountered with sterilization methods in the preparations of hydrogels for biological applications...
December 5, 2016: Current Drug Delivery
https://www.readbyqxmd.com/read/27918967/nanoencapsulation-an-efficient-and-promising-approach-to-maximize-wound-healing-efficacy-of-curcumin-a-review-of-new-trends-and-state-of-the-art
#3
REVIEW
Zahid Hussain, Hnin Ei Thu, Shiow-Fern Ng, Shahzeb Khan, Haliza Katas
Wound healing is a multifarious and vibrant process of replacing devitalized and damaged cellular structures, leading to restoration of the skin's barrier function, re-establishment of tissue integrity, and maintenance of the internal homeostasis. Curcumin (CUR) and its analogs have gained widespread recognition due to their remarkable anti-inflammatory, anti-infective, anticancer, immunomodulatory, antioxidant, and wound healing activities. However, their pharmaceutical significance is limited due to inherent hydrophobic nature, poor water solubility, low bioavailability, chemical instability, rapid metabolism and short half-life...
November 30, 2016: Colloids and Surfaces. B, Biointerfaces
https://www.readbyqxmd.com/read/27915492/preparation-and-in-vitro-evaluation-of-melatonin-loaded-ha-pva-gelformulations
#4
Sakine Tuncay Tanrıverdi, Catalina Natalia Cheaburu-Yilmaz, Sonia Carbone, Özgen Özer
Melatonin loaded hyaluronic acid and poly(vinyl alcohol) gels were prepared by using freeze-thaw technique and an emulsion method followed by freeze-thaw technique to produce a new synergistic system for topical application. Freeze-thaw hydrogels and emulgels were characterized by means of Fourier Transform Infrared Spectroscopy, rheology and swelling tests. The porous structure of the hydrogels was shown by scanning electron microscopy observations and thermal properties were tested by Differential Scanning Calorimetry measurements...
December 5, 2016: Pharmaceutical Development and Technology
https://www.readbyqxmd.com/read/27915024/extracellular-matrix-hydrogels-from-decellularized-tissues-structure-and-function
#5
REVIEW
Lindsey T Saldin, Madeline C Cramer, Sachin S Velankar, Lisa J White, Stephen F Badylak
: Extracellular matrix (ECM) bioscaffolds prepared from decellularized tissues have been used to facilitate constructive and functional tissue remodeling in a variety of clinical applications. The discovery that these ECM materials could be solubilized and subsequently manipulated to form hydrogels expanded their potential in vitro and in vivo utility; i.e. as culture substrates comparable to collagen or Matrigel, and as injectable materials that fill irregularly-shaped defects. The mechanisms by which ECM hydrogels direct cell behavior and influence remodeling outcomes are only partially understood, but likely include structural and biological signals retained from the native source tissue...
November 30, 2016: Acta Biomaterialia
https://www.readbyqxmd.com/read/27906521/modeling-the-human-scarred-heart-in-vitro-toward-new-tissue-engineered-models
#6
Janine C Deddens, Amir Hossein Sadeghi, Jesper Hjortnaes, Linda W van Laake, Marc Buijsrogge, Pieter A Doevendans, Ali Khademhosseini, Joost P G Sluijter
Cardiac remodeling is critical for effective tissue healing, however, excessive production and deposition of extracellular matrix components contribute to scarring and failing of the heart. Despite the fact that novel therapies have emerged, there are still no lifelong solutions for this problem. An urgent need exists to improve the understanding of adverse cardiac remodeling in order to develop new therapeutic interventions that will prevent, reverse, or regenerate the fibrotic changes in the failing heart...
December 1, 2016: Advanced Healthcare Materials
https://www.readbyqxmd.com/read/27900856/nanocomposite-hydrogels-and-their-applications-in-tissue-engineering
#7
Andisheh Motealleh, Nermin Seda Kehr
Nanocomposite (NC) hydrogels, organic-inorganic hybrid materials, are of great interest as artificial three-dimensional (3D) biomaterials for biomedical applications. NC hydrogels are prepared in water by chemically or physically cross-linking organic polymers with nanomaterials (NMs). The incorporation of hard inorganic NMs into the soft organic polymer matrix enhances the physical, chemical, and biological properties of NC hydrogels. Therefore, NC hydrogels are excellent candidates for artificial 3D biomaterials, particularly in tissue engineering applications, where they can mimic the chemical, mechanical, electrical, and biological properties of native tissues...
November 30, 2016: Advanced Healthcare Materials
https://www.readbyqxmd.com/read/27892593/dual-mode-refractive-index-and-charge-sensing-to-investigate-complex-surface-chemistry-on-nanostructures
#8
Nikhil Bhalla, Doojin Lee, Shivani Sathish, Amy Q Shen
This work presents a novel dual-mode charge and refractive index sensitive device integrated with nanoplasmonic islands, for the first time, on insulator-semiconductor junctions. The developed nano-metal-insulator semiconductor (nMIS) sensor facilitates simultaneous detection of charge and mass changes on the nanoislands due to the binding of biomolecules. The charging of the nanoislands is traced by using the capacitive field-effect electrolyte-metal-insulator-semiconductor structure and the refractive index changes are quantified by measuring the change in the localized surface plasmon resonances of the nanoislands...
November 28, 2016: Nanoscale
https://www.readbyqxmd.com/read/27884616/mechanical-properties-of-contact-lenses-the-contribution-of-measurement-techniques-and-clinical-feedback-to-50-years-of-materials-development
#9
REVIEW
Tarnveer Singh Bhamra, Brian J Tighe
PURPOSE: This review summarises the way in which mechanical property measurements combined with clinical perception have influenced the last half century of materials evolution in contact lens development. METHODS: Literature concerning the use of in-vitro testing in assessment of the mechanical behaviour of contact lenses, and the mutual deformation of the lens material and ocular tissue was examined. Tensile measurements of historic and available hydrogel lenses have been collected, in addition to manufacturer-generated figures for the moduli of commercial silicone hydrogel lenses...
November 21, 2016: Contact Lens & Anterior Eye: the Journal of the British Contact Lens Association
https://www.readbyqxmd.com/read/27879049/double-helix-structure-in-carrageenan-metal-hydrogels-a-general-approach-to-porous-metal-sulfides-carbon-aerogels-with-excellent-sodium-ion-storage
#10
Daohao Li, Dongjiang Yang, Xianfeng Yang, Yu Wang, Ziqi Guo, Yanzhi Xia, Shenglei Sun, Shaojun Guo
The metal sulfide-carbon nanocomposite is a new class of anode material for sodium ion batteries, but its development is restricted by its relative poor rate ability and cyclic stability. Herein, we report the use of double-helix structure of carrageenan-metal hydrogels for the synthesis of 3D metal sulfide (Mx Sy ) nanostructure/carbon aerogels (CAs) for high-performance sodium-ion storage. The method is unique, and can be used to make multiple Mx Sy /CAs (such as FeS/CA, Co9 S8 /CA, Ni3 S4 /CA, CuS/CA, ZnS/CA, and CdS/CA) with ultra-small nanoparticles and hierarchical porous structure by pyrolyzing the carrageenan-metal hydrogels...
November 23, 2016: Angewandte Chemie
https://www.readbyqxmd.com/read/27874294/dacryoadenitis-and-extraocular-muscle-inflammation-associated-with-contact-lens-related-acanthamoeba-keratitis-a-case-report-and-review-of-the-literature
#11
Tomris Sengor, Erdal Yuzbasioglu, Sevda Aydın Kurna, Murat Irkec, Ahmet Altun, Kubra Kökcen, Nazli Gul Yalcin
The present report discusses a new case of dacryoadenitis with extraocular muscle inflammation associated with Acanthamoeba keratitis (AK) in a contact lens wearer. A 41-year-old male, who has worn silicone hydrogel contact lenses on an extended basis for about 10 years, attended with the complaints of vision disturbance, hyperemia, and pain in his right eye. His history revealed that 1.5 month ago, he had been diagnosed with allergic conjunctivitis and had used steroid eye drops. Biomicroscopic examination revealed eyelid edema, chemosis, and ring infiltration, radial keratoneuritis and an epithelial defect in the cornea...
November 22, 2016: Orbit
https://www.readbyqxmd.com/read/27872015/self-hardening-and-thermoresponsive-alpha-tricalcium-phosphate-pluronic-pastes
#12
Yassine Maazouz, Edgar B Montufar, Julien Malbert, Montserrat Espanol, Maria-Pau Ginebra
: Although calcium phosphate cements (CPCs) are used for bone regeneration in a wide range of clinical applications, various physicochemical phenomena are known to hinder their potential use in minimally invasive surgery or in highly vascularized surgical sites, mainly because of their lack of injectability or their low washout resistance. The present work shows that the combination of CPCs with an inverse-thermoresponsive hydrogel is a good strategy for finely tuning the cohesive and rheological properties of CPCs to achieve clinical acceptable injectability to prevent phase separation during implantation and cohesion to avoid washout of the paste...
November 18, 2016: Acta Biomaterialia
https://www.readbyqxmd.com/read/27865562/photo-and-thermo-responsive-multicompartment-hydrogels-for-synergistic-delivery-of-gemcitabine-and-doxorubicin
#13
Cheng Wang, Guoying Zhang, Guhuan Liu, Jinming Hu, Shiyong Liu
Hydrogels have found promising applications in drug delivery due to their biocompatibility, high drug loading capability, and tunable release profiles. However, hydrogel-based carriers are primarily employed for delivering hydrophilic payloads while hydrophobic drugs cannot be efficiently delivered due to the lack of hydrophobic domains within conventional hydrogel matrices. Herein, we report that thermo- and photo-responsive hydrogels could be constructed from amphiphilic triblock copolymers, poly(N-isopropylacrylamide)-b-poly(4-acryloylmorpholine)-b-poly(2-((((2-nitrobenzyl)oxy)carbonyl) amino)ethyl methacrylate) (PNIPAM-b-PNAM-b-PNBOC), and the resulting hydrogels could be further engineered a new carrier for both hydrophilic gemcitabine (GCT) and hydrophobic doxorubicin (DOX)...
November 16, 2016: Journal of Controlled Release: Official Journal of the Controlled Release Society
https://www.readbyqxmd.com/read/27864064/an-emerging-class-of-amphiphilic-dendrimers-for-pharmaceutical-and-biomedical-applications-janus-amphiphilic-dendrimers
#14
REVIEW
Dhiraj R Sikwal, Rahul S Kalhapure, Thirumala Govender
In recent years, a new class of dendrimer, known as Janus dendrimers (JDs), has attracted much attention due to their different structures and properties to the conventional symmetric forms. The broken symmetry of JDs offers the opportunity to form complex self-assembled materials, and presents new sets of properties that are presently inconceivable for homogeneous or symmetrical dendrimers. Due to their unique features, JDs have a promising future in pharmaceutical and biomedical fields, as seen from the recent interest in their application in conjugating multiple drugs and targeting moieties, forming supramolecular hydrogels, enabling micellar delivery systems, and preparing nano-vesicles, known as dendrimersomes, for drug encapsulation...
November 15, 2016: European Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/27849094/synthetic-hydrogel-mimics-of-the-nuclear-pore-complex-display-selectivity-dependent-on-fg-repeat-concentration-and-electrostatics
#15
Alicia K Friedman, Lane A Baker
Synthetic hydrogels were utilized to explore influence of both charge and phenylalanine-glycine (FG) repeat concentration on translocation of select proteins. Hydrogels studied represent a biomimetic platform of the nuclear pore complex (NPC) found in eukaryotic cells. Polyacrylamide/phenylalanine-serine-phenylalanine-glycine (FSFG) peptide copolymers have previously demonstrated similar selectivity to native NPCs. Entry of a nuclear transport receptor (Impβ) into hydrogels was monitored with fluorescence microscopy and observed to be greater within gels that contained larger concentrations of FG peptide...
November 16, 2016: Soft Matter
https://www.readbyqxmd.com/read/27842839/thermo-sensitive-injectable-hydrogel-based-on-the-physical-mixing-of-hyaluronic-acid-and-pluronic-f-127-for-sustained-nsaid-delivery
#16
Young-Seok Jung, Wooram Park, Hyejin Park, Deok-Keun Lee, Kun Na
The aim of this research is the development of a new type of intra-articularly injectable thermo-sensitive hydrogels for the long-term delivery of Piroxicam (PX). The thermo-sensitive hydrogel was prepared by the simple physical mixing of HA and Pluronic F-127 (HP) in aqueous solution. The addition of high-molecular-weight HA not only enhanced the mechanical strength of the hydrogel but also elicited a sustained drug release. This result could be attributed to the high-molecular-weight HA-assisted inter-micellar packing in the hydrogel inner structure...
January 20, 2017: Carbohydrate Polymers
https://www.readbyqxmd.com/read/27836656/investigation-of-different-cross-linking-approaches-on-3d-gelatin-scaffolds-for-tissue-engineering-application-a-comparative-analysis
#17
K Gopal Shankar, Natalia Gostynska, Monica Montesi, Silvia Panseri, Simone Sprio, Elizaveta Kon, Maurilio Marcacci, Anna Tampieri, Monica Sandri
The present study aims to investigate the physical-chemical and biological features exhibited by porous scaffolds for regeneration of cartilaginous tissues obtained through stabilization of 3D gelatin hydrogels by physical (DHT), chemical (BDDGE) and natural (Genipin) cross-linking approaches. The study aimed at comparatively assessing the porous microstructure and the long-term resistance of the scaffolds upon degradation in wet physiological conditions (37°C, pH=7.4). The degree of cross-linking increases as function of incorporation of cross-linkers which was maximum up to 73% for BDDGE...
November 8, 2016: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/27835935/a-new-vertebral-body-replacement-strategy-using-expandable-polymeric-cages
#18
Xifeng Liu, Alex Paulsen, Hugo Giambini, Ji Guo, Alan Miller, Po-Chun Lin, Michael J Yaszemski, Lichun Lu
We have developed a novel polymeric expandable cage that can be delivered via a posterior-only surgical approach for the treatment of non-contained vertebral defects. This approach is less invasive than an anterior-only or combined approach and much more cost effective than currently used expandable metal cages. The polymeric expandable cage is composed of oligo poly(ethylene glycol) fumarate (OPF), a hydrogel that has been previously shown to have excellent nerve and bone tissue biocompatibility. OPF hydrogel cages can expand to twice their original diameter and length within a surgical time frame following hydration...
November 11, 2016: Tissue Engineering. Part A
https://www.readbyqxmd.com/read/27830490/soft-3d-printed-phantom-of-the-human-kidney-with-collecting-system
#19
Fabian Adams, Tian Qiu, Andrew Mark, Benjamin Fritz, Lena Kramer, Daniel Schlager, Ulrich Wetterauer, Arkadiusz Miernik, Peer Fischer
Organ models are used for planning and simulation of operations, developing new surgical instruments, and training purposes. There is a substantial demand for in vitro organ phantoms, especially in urological surgery. Animal models and existing simulator systems poorly mimic the detailed morphology and the physical properties of human organs. In this paper, we report a novel fabrication process to make a human kidney phantom with realistic anatomical structures and physical properties. The detailed anatomical structure was directly acquired from high resolution CT data sets of human cadaveric kidneys...
November 9, 2016: Annals of Biomedical Engineering
https://www.readbyqxmd.com/read/27830453/facile-modulation-of-cell-adhesion-to-a-poly-ethylene-glycol-diacrylate-film-with-incorporation-of-polystyrene-nano-spheres
#20
Wenguang Yang, Haibo Yu, Gongxin Li, Yuechao Wang, Lianqing Liu
Poly(ethylene glycol) diacrylate (PEGDA) is a common hydrogel that has been actively investigated for various tissue engineering applications owing to its biocompatibility and excellent mechanical properties. However, the native PEGDA films are known for their bio-inertness which can hinder cell adhesion, thereby limiting their applications in tissue engineering and biomedicine. Recently, nano composite technology has become a particularly hot topic, and has led to the development of new methods for delivering desired properties to nanomaterials...
December 2016: Biomedical Microdevices
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