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https://www.readbyqxmd.com/read/28337850/high-throughput-screening-of-vascular-endothelium-destructive-or-protective-microenvironments-cooperative-actions-of-extracellular-matrix-composition-stiffness-and-structure
#1
Yonghui Ding, Michael Floren, Wei Tan
Pathological modification of the subendothelial extracellular matrix (ECM) has closely been associated with endothelial activation and subsequent cardiovascular disease progression. To understand regulatory mechanisms of these matrix modifications, the majority of previous efforts have focused on the modulation of either chemical composition or matrix stiffness on 2D smooth surfaces without simultaneously probing their cooperative effects on endothelium function on in vivo like 3D fibrous matrices. To this end, a high-throughput, combinatorial microarray platform on 2D and 3D hydrogel settings to resemble the compositions, stiffness, and structure of healthy and diseased subendothelial ECM has been established, and further their respective and combined effects on endothelial attachment, proliferation, inflammation, and junctional integrity have been investigated...
March 24, 2017: Advanced Healthcare Materials
https://www.readbyqxmd.com/read/28337667/self-assembled-polyelectrolyte-complexes-films-as-efficient-compression-coating-layers-for-controlled-releasing-tablets
#2
Wenyan Li, Mengmeng Huo, Arka Sen Chaudhuri, Chen Yang, Dazhong Cao, Zhenghong Wu, Xiaole Qi
Currently, polysaccharide-based hydrogels are widely studied macromolecular networks to modify drug dissolution from controlled-releasing matrix tablets. Among them, polyelectrolyte complexes (PEC) films consisted of chitosan (CS) and sodium alginate (SA) could be obtained via spontaneously assembling under physiological gastrointestinal environment. Here, we utilized these self-assembled PEC films as an efficient coating materials to develop controlled-released matrix tablets through compression coating process, with paracetamol (APAP) as model drug...
May 2017: Journal of Materials Science. Materials in Medicine
https://www.readbyqxmd.com/read/28334520/new-approach-for-vertical-bone-regeneration-using-in-situ-gelling-and-sustained-bmp-2-releasing-poly-phosphazene-hydrogel-system-on-peri-implant-site-with-critical-defect-in-a-canine-model
#3
Bo-Bae Seo, Hae-Im Chang, Hyuck Choi, Jeong-Tae Koh, Kwi-Dug Yun, Jae-Yeol Lee, Soo-Chang Song
An injectable hydrogel system with sustained bone morphogenetic protein 2 (BMP-2) release ability was developed for vertical bone regeneration at peri-implant sites and enhanced osseointegration of dental implants. In three young male beagle dogs, a pair of defects was created on both sides of the mandibular bone. Next, two implants were transplanted into each defect. In situ gelling polymer solutions with or without BMP-2 were applied to cover the implants and mandibular defects. The effects of the in situ gelling and sustained BMP-2 releasing (IGSR) hydrogel system on peri-implant bone regeneration were evaluated by radiologic examination, micro-computed tomography, and histomorphometric analysis...
March 23, 2017: Journal of Biomedical Materials Research. Part B, Applied Biomaterials
https://www.readbyqxmd.com/read/28331786/a-3d-chemically-modified-graphene-hydrogel-for-fast-highly-sensitive-and-selective-gas-sensor
#4
Jin Wu, Kai Tao, Yuanyuan Guo, Zhong Li, Xiaotian Wang, Zhongzhen Luo, Shuanglong Feng, Chunlei Du, Di Chen, Jianmin Miao, Leslie K Norford
Reduced graphene oxide (RGO) has proved to be a promising candidate in high-performance gas sensing in ambient conditions. However, trace detection of different kinds of gases with simultaneously high sensitivity and selectivity is challenging. Here, a chemiresistor-type sensor based on 3D sulfonated RGO hydrogel (S-RGOH) is reported, which can detect a variety of important gases with high sensitivity, boosted selectivity, fast response, and good reversibility. The NaHSO3 functionalized RGOH displays remarkable 118...
March 2017: Advanced Science (Weinheim, Baden-Wurttemberg, Germany)
https://www.readbyqxmd.com/read/28330754/injectable-nanoparticles-hydrogels-composite-as-sustained-release-system-with-stromal-cell-derived-factor-1%C3%AE-for-calvarial-bone-regeneration
#5
Lei Mi, Huaiqin Liu, Yu Gao, Hui Miao, Jianping Ruan
Repair of craniofacial bony defects remains a challenge for surgeons due to the delicate and complex anatomy of the craniofacial skeleton. Stromal cell-derived factor-1α (SDF-1α) is an important chemokine which plays a critical role in the homing of mesenchymal stem cells (MSC), while, the shortcomings including short half-life and easy degradation by enzymes made it in relatively low efficacy. In this work, SDF-1α/chitosan/carboxymeymethy-chitosan nanoparticles (SDF-1α/CS/CMCS NPs) were prepared and characterized for various parameters including morphology, particle size, zeta potential, loading efficiency and the release characteristics from thermosensitive chitosan/β-glycerol phosphate disodium salt (CS/GP) hydrogels...
March 19, 2017: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/28326790/nerve-cells-decide-to-orient-inside-an-injectable-hydrogel-with-minimal-structural-guidance
#6
Jonas C Rose, María Cámara-Torres, Khosrow Rahimi, Jens Köhler, Martin Möller, Laura De Laporte
Injectable biomaterials provide the advantage of a minimally invasive application but mostly lack the required structural complexity to regenerate aligned tissues. Here, we report a new class of tissue regenerative materials that can be injected and form an anisotropic matrix with controlled dimensions using rod-shaped, magnetoceptive microgel objects. Microgels are doped with small quantities of superparamagnetic iron oxide nanoparticles (0.0046 vol %), allowing alignment by external magnetic fields in the millitesla order...
March 24, 2017: Nano Letters
https://www.readbyqxmd.com/read/28322541/supramolecular-hydrogels-fabricated-from-supramonomers-a-novel-wound-dressing-material
#7
Wenwen Xu, Qiao Song, Jiangfei Xu, Michael J Serpe, Xi Zhang
Daily repeated wound dressing changes will lead to additional trauma to newly formed tissue and prolonging the healing process. In this letter, we designed and fabricated an easy removable wound dressing material. To accomplish this, crosslinkable supramonomers were first generated through host-guest noncovalent interaction, followed by radical copolymerization of acrylamide with supramonomer as crosslinker to fabricate supramolecular hydrogels. Benefiting from the dynamic nature of the supramonomer, the supramolecular hydrogel is able to dissolve upon exposure to memantine, an FDA approved drug, making it easily removed from a wound, representing a promising candidate for the new generation of wound dressing...
March 21, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28322402/open-channel-water-in-oil-emulsification-in-paper-based-microfluidic-devices
#8
C Li, M Boban, A Tuteja
Open-channel microfluidic devices have shown great potential in achieving a high degree of fluid control, at relatively low-cost, while enabling the opportunity for rapid fabrication. However, thus far, work in open channel microfluidics has largely focused on controlling the flow of water or other aqueous solutions. In this work we present new open channel microfluidic devices based on surfaces with patterned wettabilty that are capable of controlling the flow of virtually all high and low surface tension liquids...
March 21, 2017: Lab on a Chip
https://www.readbyqxmd.com/read/28322015/compartmentalized-spherical-collagen-microparticles-for-anisotropic-cell-culture-microenvironments
#9
Satoru Yoshida, Masahiro Takinoue, Hiroaki Onoe
This paper describes a new fabrication method for obtaining anisotropic spherical hydrogel microparticles with different types of extracellular matrix (ECM) hemispheres for use in 3D cell culture. To fabricate the microparticles, a mixture of an ECM precursor solution and sodium alginate is ejected into a calcium chloride solution under large centrifugal acceleration by a centrifuge-based microfluidic device; the calcium alginate hydrogel plays a significant role as a "sacrificial gelation template" to maintain the ECM molecules in each hemisphere...
March 21, 2017: Advanced Healthcare Materials
https://www.readbyqxmd.com/read/28319779/supramolecular-biofunctional-materials
#10
REVIEW
Jie Zhou, Jie Li, Xuewen Du, Bing Xu
This review discusses supramolecular biofunctional materials, a novel class of biomaterials formed by small molecules that are held together via noncovalent interactions. The complexity of biology and relevant biomedical problems not only inspire, but also demand effective molecular design for functional materials. Supramolecular biofunctional materials offer (almost) unlimited possibilities and opportunities to address challenging biomedical problems. Rational molecular design of supramolecular biofunctional materials exploit powerful and versatile noncovalent interactions, which offer many advantages, such as responsiveness, reversibility, tunability, biomimicry, modularity, predictability, and, most importantly, adaptiveness...
March 12, 2017: Biomaterials
https://www.readbyqxmd.com/read/28318268/mechanistic-insights-into-the-directed-assembly-of-hydrogel-blocks-mediated-by-polyelectrolytes-or-microgels
#11
Nicolas Hanauer, Pierre Luc Latreille, Xavier Banquy
In this study, we report the directed assembly of hydrogel blocks mediated by electrostatic interactions. We compared two different assembly mechanisms, one mediated by microgel particles and another mediated by direct interaction between oppositely charged blocks. The system consisted in hydrogel blocks made of an interpenetrated network of (hydroxyethyl)methacrylate-poly(ethyleneglycol)dimethacrylate (HEMA-PEGDMA) and either positively charged polyethyleneimine (PEI) or negatively charged hyaluronic acid (HA)...
March 20, 2017: Langmuir: the ACS Journal of Surfaces and Colloids
https://www.readbyqxmd.com/read/28317377/3d-printed-ultratough-hydrogel-structures-with-titin-like-domains
#12
Fengbo Zhu, Libo Cheng, Zhi Jian Wang, Wei Hong, Zi Liang Wu, Jun Yin, Jin Qian, Qiang Zheng
Titin is composed of repeated modular domains which unfold and dissipate energy upon loading. Here we employed such molecular-level paradigm to fabricate macroscopic ultratough hydrogel structures with titin-like domains, enabled by three-dimensional printing with multiple nozzles. Under stretch, the relatively thin and weak gel fibers in the printed structures break first and the hidden lengths postpone the failure of the main structures, mimicking the toughening principle in titin. These titin-like folded domains have been incorporated into a synthetic spider-web, which shows significantly enhanced extensibility and toughness...
March 22, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28314923/new-interventional-treatment-model-for-pancreatic-neoplasms-using-gemcitabine-eluting-hydrogel-devices-in-vitro-and-in-vivo-results
#13
Ruben Lopez-Benitez, David Benz, Yue Wu, Xinping Wu, Samuel Chen, Gregory M Cruise
OBJECTIVES: In vitro and in vivo evaluation of fast- and slow-release gemcitabine-eluting hydrogel (GEH) devices. METHODS: For in vitro elution, the GEH devices were placed in phosphate-buffered saline at 37 °C. Periodically, the solution was analyzed for gemcitabine. The devices consisting of fast release (n = 8), slow release (n = 6), or bland (n = 4) were delivered through a 5-Fr catheter into the gastroduodenal artery of a pig. Additionally, four pigs were treated with intravenous (IV) injection of gemcitabine...
March 17, 2017: Cardiovascular and Interventional Radiology
https://www.readbyqxmd.com/read/28314117/three-dimensional-cell-cultures-in-drug-discovery-and-development
#14
Ye Fang, Richard M Eglen
The past decades have witnessed significant efforts toward the development of three-dimensional (3D) cell cultures as systems that better mimic in vivo physiology. Today, 3D cell cultures are emerging, not only as a new tool in early drug discovery but also as potential therapeutics to treat disease. In this review, we assess leading 3D cell culture technologies and their impact on drug discovery, including spheroids, organoids, scaffolds, hydrogels, organs-on-chips, and 3D bioprinting. We also discuss the implementation of these technologies in compound identification, screening, and development, ranging from disease modeling to assessment of efficacy and safety profiles...
March 1, 2017: SLAS Discov
https://www.readbyqxmd.com/read/28304158/near-infrared-light-responsive-semiconductor-polymer-composite-hydrogels-toward-spatial-temporal-controlled-release-via-photothermal-sponge-effect
#15
Yingjie Wu, Kai Wang, Shuo Huang, Cangjie Yang, Mingfeng Wang
Near-infrared (NIR) light-responsive hydrogels are important for biomedical applications such as remotely controlled release, but the NIR agents previously used have been largely limited to heavy-metal inorganic materials such as gold nanoparticles. In this article, we report a new type of NIR photothermal responsive hydrogels, which could undergo structural changes in response to NIR light for biomedical applications in drug delivery and controlled release. The hydrogels synthesized by integrating a narrow bandgap semiconductor polymer poly(diketopyrrolopyrrole-alt-3,4-ethylenedioxythiophene) (PDPPEDOT) with polymerization of N-isopropylacrylamide (NIPAM) show rapid and reversible mechanical shrinkage upon NIR light irradiation and can serve as carriers for anticancer drug loading and spatial/temporal control of drug release...
March 17, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28303935/multiscale-microenvironmental-perturbation-of-pluripotent-stem-cell-fate-and-self-organization
#16
Yoji Tabata, Matthias P Lutolf
The combination of microfluidics with engineered three-dimensional (3D) matrices can bring new insights into the fate regulation of stem cells and their self-organization into organoids. Although there has been progress in 3D stem cell culturing, most existing in vitro methodologies do not allow for mimicking of the spatiotemporal heterogeneity of stimuli that drive morphogenetic processes in vivo. To address this, we present a perfusion-free microchip concept for the in vitro 3D perturbation of stem cell fate...
March 17, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28303535/hyaluronic-acid-based-hydrogel-coating-does-not-affect-bone-apposition-at-the-implant-surface-in-a-rabbit-model
#17
W Boot, D Gawlitta, P G J Nikkels, B Pouran, M H P van Rijen, W J A Dhert, H Ch Vogely
BACKGROUND: Uncemented orthopaedic implants rely on the bone-implant interface to provide stability, therefore it is essential that a coating does not interfere with the bone-forming processes occurring at the implant interface. In addition, local application of high concentrations of antibiotics for prophylaxis or treatment of infection may be toxic for osteoblasts and could impair bone growth. QUESTIONS/PURPOSES: In this animal study, we investigated the effect of a commercially available hydrogel, either unloaded or loaded with 2% vancomycin...
March 16, 2017: Clinical Orthopaedics and related Research
https://www.readbyqxmd.com/read/28301717/glucose-triggered-insulin-release-from-fe3-cross-linked-alginate-hydrogel-experimental-study-and-theoretical-modeling
#18
Evgeny Katz, Sabrina Scheja, Sergii Domanskyi, Maria Gamella, Kelly L Wormwood, Costel C Darie, Arshak Poghossian, Michael J Schöning, Artem Melman, Vladimir Privman
We study the mechanisms involved in the release, triggered by the application of glucose, of insulin entrapped in Fe3+-cross-linked alginate hydrogel particles further stabilized with a polyelectrolyte. Platelet-shaped alginate particles are synthesized containing enzyme glucose oxidase conjugated with silica nanoparticles, which are also entrapped in the hydrogel. Glucose diffuses in from solution, and production of hydrogen peroxide is catalyzed by the enzyme within the hydrogel. We argue that, specifically for the Fe3+-cross-linked systems, the produced hydrogen peroxide is further converted to free radicals via a Fenton-type reaction catalyzed by the iron cations...
March 16, 2017: Chemphyschem: a European Journal of Chemical Physics and Physical Chemistry
https://www.readbyqxmd.com/read/28301139/designing-hydrogels-for-on-demand-therapy
#19
Nuria Oliva, João Conde, Kui Wang, Natalie Artzi
Systemic administration of therapeutic agents has been the preferred approach to treat most pathological conditions, in particular for cancer therapy. This treatment modality is associated with side effects, off-target accumulation, toxicity, and rapid renal and hepatic clearance. Multiple efforts have focused on incorporating targeting moieties into systemic therapeutic vehicles to enhance retention and minimize clearance and side effects. However, only a small percentage of the nanoparticles administered systemically accumulate at the tumor site, leading to poor therapeutic efficacy...
March 16, 2017: Accounts of Chemical Research
https://www.readbyqxmd.com/read/28300395/constructing-tissue-like-complex-structures-using-cell-laden-dna-hydrogel-bricks
#20
Yijie Wang, Yu Shao, Xiaozhou Ma, Bini Zhou, Alan Faulkner-Jones, Wenmiao Shu, Dongsheng Liu
Tissue engineering has long been a challenge due to the difficulty of addressing the requirements that such an engineered tissue must meet. In this paper, we developed a new "brick-to-wall" based on unique properties of DNA supramolecular hydrogels to fabricate three-dimensional (3D) tissue-like structures: different cell types are encapsulated in DNA hydrogel bricks which are then combined to build 3D structures. Signal-responsiveness of cells through the DNA gels was evaluated and it was discovered that the gel permits cell migration in 3D...
March 16, 2017: ACS Applied Materials & Interfaces
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