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https://www.readbyqxmd.com/read/29777958/sssupramolecular-poly-acrylic-acid-f127-hydrogel-with-hydration-controlled-nitric-oxide-release-for-enhancing-wound-healing
#1
Mathilde Champeau, Valéria Póvoa, Lucas Militão, Flávia Cabrini, Guilherme F Picheth, Florian Meneau, Carlos P Jara, Eliana P de Araujo, Marcelo G de Oliveira
Topical nitric oxide (NO) delivery has been shown to accelerate wound healing. However, delivering NO to wounds at appropriate rates and doses requires new biomaterial-based strategies. Here, we describe the development of supramolecular interpolymer complex hydrogels comprising PEO-PPO-PEO (F127) micelles embedded in a poly(acrylic acid) (PAA) matrix, with S-nitrosoglutathione (GSNO) molecules dissolved in the hydrophilic domain. We show that PAA:F127/GSNO hydrogels start releasing NO upon hydration at rates controlled by their rates of water absorption...
May 16, 2018: Acta Biomaterialia
https://www.readbyqxmd.com/read/29777818/influence-of-degree-of-substitution-and-folic-acid-coinitiator-on-pullulan-hema-hydrogel-properties-crosslinked-under-visible-light-initiating-system
#2
Elbadawy A Kamoun, M A Abu-Seaid, A S Doma, Henning Menzel, Xin Chen
Hydroxyethyl methacrylate-derivative pullulan (pullulan-HEMA) was synthesized by activation of HEMA followed by catalyzed coupling reaction for adjusting the degree of substitution (DS) of copolymer. Pullulan-HEMA was photocrosslinked using new three-components photoinitiating system composed of carboxylated camphorquinone-folic acid-iodonium salt under visible light. Folic acid was employed as new coinitiator for improving the entire hydrogel properties and avoiding harms of traditional used tertiary amine coinitiators...
May 16, 2018: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/29775296/incorporation-of-a-theranostic-two-tone-luminescent-silver-complex-into-biocompatible-agar-hydrogel-composite-for-the-eradication-of-eskape-pathogens-in-a-skin-and-soft-tissue-infection-model
#3
Miguel N Pinto, Jorge Martinez-Gonzalez, Indranil Chakraborty, Pradip K Mascharak
Microbial invasion and colonization of the skin and underlying soft tissues are among the most common types of infections, becoming increasingly prevalent in hospital settings. Systemic antibiotic chemotherapies are now extremely limited due to emergence of drug-resistant Gram-positive and multidrug-resistant Gram-negative bacterial strains. Topical administration of antimicrobials provides an effective route for the treatment of skin and soft tissue infections (SSTIs). Therefore, the development of new and effective materials for the delivery of these agents is of paramount importance...
May 18, 2018: Inorganic Chemistry
https://www.readbyqxmd.com/read/29775275/a-high-performance-and-recyclable-al-air-coin-cell-based-on-eco-friendly-chitosan-hydrogel-membranes
#4
Yisi Liu, Qian Sun, Xiaofei Yang, Jianneng Liang, Biqiong Wang, Alicia Koo, Ruying Li, Jie Li, Xueliang Sun
Aluminum-air batteries are a promising power supply for electronics due to its low cost and high energy density. However, portable coin-type Al-air batteries operating under ambient air condition for small electronic appliances have rarely been reported. Herein, coin cell-type Al-air batteries using cost-effective and eco-friendly chitosan hydrogel membranes modified by SiO2, SnO2, and ZnO have been prepared and assembled. The Al-air coin cell employing chitosan hydrogel membrane containing 10 wt.% SiO2 as a separator exhibits better discharge performance with a higher flat voltage plateau, longer discharge duration, and higher power density than the cells using a chitosan hydrogel membrane containing SnO2 or ZnO...
May 18, 2018: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/29773397/self-healable-tough-supramolecular-hydrogels-crosslinked-by-poly-cyclodextrin-through-host-guest-interaction
#5
Tingting Cai, Shuangjun Huo, Tao Wang, Weixiang Sun, Zhen Tong
A new supramolecular hydrogel with superior self-healing and shape memory properties was synthesized via in-situ copolymerization of the adamantane-containing monomer N-adamantylacrylamide (Ad-AAm) and monomer acrylic acid (AAc) in the polycyclodextrin (PCD) aqueous solution, where PCD served as the polyfunctional physical cross-linker. The PCD-Ad hydrogels showed strength of 40 kPa with breaking strain of 600%, but small tensile loading-unloading hysteresis and residual deformation benefited from the reversible crosslinking structure...
August 1, 2018: Carbohydrate Polymers
https://www.readbyqxmd.com/read/29773377/mechanically-viscoelastic-nanoreinforced-hybrid-hydrogels-composed-of-polyacrylamide-sodium-carboxymethylcellulose-graphene-oxide-and-cellulose-nanocrystals
#6
Anuj Kumar, Kummara Madhusudana Rao, Sung Soo Han
Polyacrylamide-sodium carboxymethylcellulose (PMC) hybrid hydrogels reinforced with graphene oxide (GO) and/or cellulose nanocrystals (CNCs) were prepared via in situ free-radical polymerization. In this work, GO nanosheets were freshly synthesized by modified Hummer's method alongwith the aqueous suspension of CNCs by acid-hydrolysis. In addition, the effect of GO content (1.5 wt%) and CNCs (from 2.5 wt% to 10.0 wt%) was investigated in these quaternary hydrogels. The results showed good pseudo-plastic behavior, self-healing ability, mechanical performance, and shape-recovery behavior of the hybrid hydrogels reinforced with GO and CNCs content...
August 1, 2018: Carbohydrate Polymers
https://www.readbyqxmd.com/read/29773363/characterization-of-a-fluorescent-hydrogel-synthesized-using-chitosan-polyvinyl-alcohol-and-9-anthraldehyde-for-the-selective-detection-and-discrimination-of-trace-fe-3-and-fe-2-in-water-for-live-cell-imaging
#7
Santu Maity, Nira Parshi, Chandraday Prodhan, Keya Chaudhuri, Jhuma Ganguly
A three-dimensional fluorescent hydrogel based on chitosan, polyvinyl alcohol and 9-anthraldehyde (ChPA) has been successfully designed and synthesized for the selective detection and discrimination of Fe3+ and Fe2+ in aqueous environment. The unique characteristics of ChPA has been confirmed by the Fourier-transform infrared spectroscopy (FTIR), rheological measurement, scanning electron microscopy (SEM), thermogravimetry and differential thermogravimetry (TG-DTG), ultraviolet-visible spectroscopy (UV-vis), fluorescence studies, transmission electron microscopy (TEM), energy dispersive x-ray spectroscopy (EDX), x-ray diffraction (XRD) and dynamic light scattering (DLS)...
August 1, 2018: Carbohydrate Polymers
https://www.readbyqxmd.com/read/29765659/self-assembly-behaviours-of-peptide-drug-conjugates-influence-of-multiple-factors-on-aggregate-morphology-and-potential-self-assembly-mechanism
#8
Qin Fan, Yujie Ji, Jingjing Wang, Li Wu, Weidong Li, Rui Chen, Zhipeng Chen
Peptide-drug conjugates (PDCs) as self-assembly prodrugs have the unique and specific features to build one-component nanomedicines. Supramolecular structure based on PDCs could form various morphologies ranging from nanotube, nanofibre, nanobelt to hydrogel. However, the assembly process of PDCs is too complex to predict or control. Herein, we investigated the effects of extrinsic factors on assembly morphology and the possible formation of nanostructures based on PDCs. To this end, we designed a PDC consisting of hydrophobic drug ( S )-ketoprofen (Ket) and valine-glutamic acid dimeric repeats peptide (L-VEVE) to study their assembly behaviour...
April 2018: Royal Society Open Science
https://www.readbyqxmd.com/read/29763774/precisely-controlled-delivery-of-magnesium-ions-thru-sponge-like-monodisperse-plga-nano-mgo-alginate-core-shell-microsphere-device-to-enable-in-situ-bone-regeneration
#9
Zhengjie Lin, Jun Wu, Wei Qiao, Ying Zhao, Karen H M Wong, Paul K Chu, Liming Bian, Shuilin Wu, Yufeng Zheng, Kenneth M C Cheung, Frankie Leung, Kelvin W K Yeung
A range of magnesium ions (Mg2+ ) used has demonstrated osteogenic tendency in vitro. Hence, we propose to actualize this concept by designing a new system to precisely control the Mg2+ delivery at a particular concentration in vivo in order to effectively stimulate in-situ bone regeneration. To achieve this objective, a monodisperse core-shell microsphere delivery system comprising of poly (lactic-co-glycolic acid) (PLGA) biopolymer, alginate hydrogel, and magnesium oxide nano-particles has been designed by using customized microfluidic capillary device...
May 8, 2018: Biomaterials
https://www.readbyqxmd.com/read/29762206/urushiol-patch-test-using-the-t-r-u-e-test-system
#10
Yesul Kim, Amy Longenecker, Mahmoud A ElSohly, Waseem Gul, Raymond J Hage, Curtis P Hamann, James G Marks
BACKGROUND: Poison ivy, poison oak, and poison sumac are the most common causes of allergic contact dermatitis in North America. Although extensive efforts have been made to develop therapies that prevent and treat allergic contact dermatitis to these plants, there lacks an entirely effective method, besides complete avoidance. Efforts to develop a more effective preventive therapy, such as a vaccine, are ongoing. To accurately evaluate the efficacy of these new therapies, an appropriate assessment tool is needed...
May 2018: Dermatitis
https://www.readbyqxmd.com/read/29760741/establishing-a-surgical-procedure-for-rhesus-epiretinal-scaffold-implantation-with-hipsc-derived-retinal-progenitors
#11
Ziming Luo, Kang Li, Kaijing Li, Bikun Xian, Ying Liu, Sijing Yang, Chaochao Xu, Zhigang Fan, Shoutao Lu, Haijun Zhang, Jian Ge
Background: To develop an effective surgical procedure for cellular scaffold epiretinal implantation in rhesus, facilitating subsequent epiretinal stem cell transplantation. Methods: Retinal progenitors were seeded onto a poly(lactic-co-glycolic) acid (PLGA) scaffold. First, the cellular scaffolds were delivered by 18G catheter or retinal forceps into rabbit epiretinal space ( n = 50). Then, the cell survival rate was evaluated by Cell Counting Kit-8 (CCK-8). Second, three methods of scaffold fixation, including adhesion after gas-liquid exchange ( n = 1), tamponade by hydrogel ( n = 1), and fixation by retinal tacks ( n = 4), were performed in rhesus monkeys...
2018: Stem Cells International
https://www.readbyqxmd.com/read/29757942/biomedical-potential-of-ultrafine-ag-nanoparticles-coated-on-poly-gamma-glutamic-acid-hydrogel-with-special-reference-to-wound-healing
#12
Yu Wang, Chunyan Dou, Guidong He, Litong Ban, Liang Huang, Zheng Li, Jixian Gong, Jianfei Zhang, Peng Yu
In wound care management, the prevention of wound infection and the retention of an appropriate level of moisture are two major challenges. Therefore, designing an excellent antibacterial hydrogel with a suitable water-adsorbing capacity is very important to improve the development of wound dressings. In this paper, a novel silver nanoparticles/poly (gamma-glutamic acid) (γ-PGA) composite dressing was prepared for biomedical applications. The promoted wound-healing ability of the hydrogels were systematically evaluated with the aim of attaining a novel and effective wound dressing...
May 14, 2018: Nanomaterials
https://www.readbyqxmd.com/read/29757746/biomedical-materials-learn-to-heal-themselves-self-healing-polymers-hydrogels-and-artificial-muscles-are-mimicking-nature-s-repair-mechanisms
#13
David L Chandler
Maintaining sterility in emergency and operating rooms can be challenging, especially in cases of highly infectious disease outbreaks or toxic spills. A simple nick in a surgical glove under such circumstances could have deadly consequences. But, now, a variety of promising new materials in development may lead to everything from self-healing gloves and bandages to bone, blood vessel, and muscle scaffolding implants that could repair themselves the way tissues do. In some cases, repair might be triggered by an external stimulus, such as heat; in other cases, these materials would naturally heal by themselves over time...
May 2018: IEEE Pulse
https://www.readbyqxmd.com/read/29754222/methods-for-generating-microbial-cocultures-that-grow-in-the-absence-of-fixed-carbon-or-nitrogen
#14
Matthew J Smith, Matthew B Francis
This work is motivated by both (1) the desire to make interesting products without the reliance on fixed carbon or fixed nitrogen using microbial cocultures, and (2) the desire to develop new methods for growing microbial communities. The bioplastic polyhydroxybutyrate (PHB), for example, is considered prohibitively expensive to make from sugar (compared to polypropylene). Utilizing and building on engineered strains of Synechococcus elongatus and Azotobacter vinelandii, we have combined a nitrogen-fixing organism with a carbon-fixing organism to make PHB from air, water, sunlight, and trace minerals...
2018: Methods in Molecular Biology
https://www.readbyqxmd.com/read/29752091/tunable-sequential-drug-delivery-system-based-on-chitosan-hyaluronic-acid-hydrogels-and-plga-microspheres-for-management-of-non-healing-infected-wounds
#15
Jinjian Huang, Jianan Ren, Guopu Chen, Zongan Li, Yan Liu, Gefei Wang, Xiuwen Wu
Treatment of non-healing infected wounds is an arduous task in clinical practice. Early antibacterial strategy and subsequent promotion of granulation tissue growth facilitate to cure the wounds. For this purpose, we fabricated a sequential drug delivery system by incorporation of an injectable hydrogel with porous PLGA microspheres. Vancomycin was linked to the injectable hydrogel via the reversible Schiff's base reaction, and VEGF were encapsulated into PLGA microspheres. After adding vancomycin, the strength and elasticity of the hydrogel were improved, and the gelation time was shortened...
August 1, 2018: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/29749707/automated-expansion-of-primary-human-t-cells-in-scalable-and-cell-friendly-hydrogel-microtubes-for-adoptive-immunotherapy
#16
Haishuang Lin, Qiang Li, Ou Wang, Jack Rauch, Braden Harm, Hendrik J Viljoen, Chi Zhang, Erika Van Wyk, Chi Zhang, Yuguo Lei
Adoptive immunotherapy is a highly effective strategy for treating many human cancers, such as melanoma, cervical cancer, lymphoma, and leukemia. Here, a novel cell culture technology is reported for expanding primary human T cells for adoptive immunotherapy. T cells are suspended and cultured in microscale alginate hydrogel tubes (AlgTubes) that are suspended in the cell culture medium in a culture vessel. The hydrogel tubes protect cells from hydrodynamic stresses and confine the cell mass less than 400 µm (in radial diameter) to ensure efficient mass transport, creating a cell-friendly microenvironment for growing T cells...
May 11, 2018: Advanced Healthcare Materials
https://www.readbyqxmd.com/read/29748197/minimally-invasive-delivery-of-hydrogel-encapsulated-amiodarone-to-the-epicardium-reduces-atrial-fibrillation
#17
Jose R Garcia, Peter F Campbell, Gautam Kumar, Jonathan J Langberg, Liliana Cesar, Juline N Deppen, Eric Y Shin, Neal K Bhatia, Lanfang Wang, Kai Xu, Frank Schneider, Brian Robinson, Andrés J García, Rebecca D Levit
BACKGROUND: Atrial fibrillation (AF) is the most common cardiac arrhythmia. Although treatment options for AF exist, many patients cannot be maintained in normal sinus rhythm. Amiodarone is an effective medication for AF but has limited clinical utility because of off-target tissue toxicity. METHODS: Here, we use a pig model of AF to test the efficacy of an amiodarone-containing polyethylene glycol-based hydrogel. The gel is placed directly on the atrial epicardium through the pericardial space in a minimally invasive procedure using a specially designed catheter...
May 2018: Circulation. Arrhythmia and Electrophysiology
https://www.readbyqxmd.com/read/29745927/-new-endovesical-chemotherapy-drugs-and-application-vehicles
#18
Emilio Rios González, Luis Martínez-Piñeiro
Urothelial bladder cancer is a very prevalent disease. At the time of diagnosis 70-80% of the cases present as non muscle invasive tumors. These tumors present a high recurrence and progression rates despite intravesical treatment with Bacille Calmette-Guerin and mitomycin C. Moreover, bladder conditions such as its wall impermeability and the fact that intravesical drugs are constantly being diluted by urine and eliminated do not favor the efficacy of intravesical treatment. This review analyzes new intravesical drugs such as gemcitabine or taxanes with promising results as alternative to the usual treatments or after their failure...
May 2018: Archivos Españoles de Urología
https://www.readbyqxmd.com/read/29745504/-self-assembling-peptide-gfs-4-nanofiber-scaffolds-for-three-dimensional-cell-cultures-and-myocardial-infarction-repair
#19
Zhenyin Chen, Yuanyuan Yue, Huinan Zhang, Chunyan Chen, Bo Liu, Xueqin Li, Jing Wen, Shuyi Wu, Zhongli Luo
The purpose of this study is to investigate the effects of self-assembling peptide GFS-4 on three-dimen-sional myocardial cell culture and tissue repair of myocardial infarction. The circular dichroism (CD) spectrum was used to detect secondary structure of GFS-4, and atomic force microscope (AFM) was used to analyze the microstructure of self-assembly. The nanofiber scaffolds self-assembled by GFS-4 were used as the three-dimensional culture material to observe the growth effect of cardiomyocytes. The model of myocardial infarction was established and the effect of GFS-4 on myocardial infarction was studied...
June 1, 2017: Sheng Wu Yi Xue Gong Cheng Xue za Zhi, Journal of Biomedical Engineering, Shengwu Yixue Gongchengxue Zazhi
https://www.readbyqxmd.com/read/29738607/ultra-bright-red-emitting-photostable-perylene-bisimide-dyes-new-indicators-for-ratiometric-sensing-of-high-ph-or-carbon-dioxide
#20
David Pfeifer, Ingo Klimant, Sergey M Borisov
New pH sensitive perylene bisimide indicator dyes were synthesised and used for fabrication of optical sensors. The highly photostable dyes show absorption/emission bands in the red/near-infrared (NIR) region of the electromagnetic spectrum, high molar absorption coefficients (up to 100 000 M-1 cm-1) and fluorescence quantum yields close to unity. The absorption and emission spectra show strong bathochromic shift upon deprotonation of imidazole nitrogen which makes the dyes promising as ratiometric fluorescent indicators...
May 8, 2018: Chemistry: a European Journal
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