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https://www.readbyqxmd.com/read/28719882/antileishmanial-activity-and-tubulin-polymerization-inhibition-of-podophyllotoxin-derivatives-on-leishmania-infantum
#1
José Miguel Escudero-Martínez, Yolanda Pérez-Pertejo, Rosa M Reguera, María Ángeles Castro, María Victoria Rojo, Carolina Santiago, Andrés Abad, Pablo Anselmo García, José Luis López-Pérez, Arturo San Feliciano, Rafael Balaña-Fouce
Leishmania microtubules play an important role not only in cell division, but also in keeping the shape of the parasite and motility of its free-living stages. Microtubules result from the self-assembly of alpha and beta tubulins, two phylogenetically conserved and very abundant eukaryotic proteins in kinetoplastids. The colchicine binding domain has inspired the discovery and development of several drugs currently in clinical use against parasites. However, this domain is less conserved in kinetoplastids and may be selectively targeted by new compounds...
June 28, 2017: International Journal for Parasitology, Drugs and Drug Resistance
https://www.readbyqxmd.com/read/28719744/high-resolution-insights-into-the-stepwise-self-assembly-of-nanofiber-from-bioactive-peptides
#2
Fude Sun, Long Chen, Xiufang Ding, Lida Xu, Xirui Zhou, Peng Wei, Jun-Feng Liang, Shi-Zhong Luo
Peptide self-assembly has a profound biological significance since self-assembled bioactive peptides are gifted with improved bioactivity as well as life-span. In this study, peptide self-assembly was investigated using a therapeutic peptide, PTP-7S (EENFLGALFKALSKLL). Combining experiments of atomic force microscopy (AFM), circular dichroism (CD) and 8-anilino-1-naphthalenesulfonic acid (ANS) fluorescence spectra, PTP-7S showing α-helix was found self-assembling into nanofibers in solution. Relying on the coarse-grained (CG) dynamic simulations, the self-assembling of PTP-7S was revealed as a stepwise process that peptide monomers first clustered into peptide-assembling units (PUs) with charged surface, and then the PUs integrated together to construct nano-fibril aggregates...
July 18, 2017: Journal of Physical Chemistry. B
https://www.readbyqxmd.com/read/28719648/oligo-ethylene-glycol-sidechain-microgels-prepared-in-absence-of-cross-linking-agent-polymerization-characterization-and-variation-of-particle-deformability
#3
Nicole Welsch, L Andrew Lyon
We present a systematic study of self-cross-linked microgels formed by precipitation polymerization of oligo ethylene glycol methacrylates. The cross-linking density of these microgels and, thus, the network flexibility can be easily tuned through the modulation of the reaction temperature during polymerization. Microgels prepared in absence of any difunctional monomer, i.e. cross-linker, show enhanced deformability and particle spreading on solid surfaces as compared to microgels cross-linked with varying amounts of poly(ethylene glycol diacrylate) (PEG-DA) in addition to self-crosslinking...
2017: PloS One
https://www.readbyqxmd.com/read/28719591/non-equilibrium-dissipative-supramolecular-materials-with-a-tunable-lifetime
#4
Marta Tena-Solsona, Benedikt Rieß, Raphael K Grötsch, Franziska C Löhrer, Caren Wanzke, Benjamin Käsdorf, Andreas R Bausch, Peter Müller-Buschbaum, Oliver Lieleg, Job Boekhoven
Many biological materials exist in non-equilibrium states driven by the irreversible consumption of high-energy molecules like ATP or GTP. These energy-dissipating structures are governed by kinetics and are thus endowed with unique properties including spatiotemporal control over their presence. Here we show man-made equivalents of materials driven by the consumption of high-energy molecules and explore their unique properties. A chemical reaction network converts dicarboxylates into metastable anhydrides driven by the irreversible consumption of carbodiimide fuels...
July 18, 2017: Nature Communications
https://www.readbyqxmd.com/read/28719579/using-primate-neural-stem-cells-cultured-in-self-assembling-peptide-nanofiber-scaffolds-to-repair-injured-spinal-cords-in-rats
#5
J-C Ye, Y Qin, Y-F Wu, P Wang, Y Tang, L Huang, M-J Ma, Y-S Zeng, H-Y Shen
This corrects the article DOI: 10.1038/sc.2016.36.
July 18, 2017: Spinal Cord
https://www.readbyqxmd.com/read/28719190/chiral-mo8o26-4-polyoxoanion-induced-three-dimensional-architectures-with-homochiral-eight-fold-interpenetrated-metal-organic-frameworks
#6
Mengjie Zhou, Dawei Yan, Yayu Dong, Xingxiang He, Yan Xu
A pair of novel chiral compounds based on homochiral 8-fold interpenetrated metal-organic frameworks (MOFs) and chiral polyoxometalates (POMs), formulated as d-[Cu(4,4'-bipy)1.5]4[Mo8O26] (d-1) and l-[Cu(4,4'-bipy)1.5]4[Mo8O26] (l-1) (4,4'-bipy = 4,4'-bipyridine), have been successfully synthesized and characterized by single crystal X-ray diffraction, infrared, thermogravimetric analysis, elemental analysis, and solid circular dichroism spectra. Structural analysis indicates that two compounds are enantiomers...
July 18, 2017: Inorganic Chemistry
https://www.readbyqxmd.com/read/28719108/isothermal-chirality-switching-with-non-polarized-light
#7
Mohamed Alaasar, Silvio Poppe, Qingshu Dong, Feng Liu, Carsten Tschierske
Spontaneous mirror symmetry breaking is a fundamental process for development of chirality in natural and in artificial self-assembled systems. Here we report a new series of triple chain azobenzene based rod-like compounds, which for the first time show mirror symmetry breaking in an isotropic liquid occurring adjacent to a lamellar LC phase. The transition between the lamellar phase and the symmetry broken liquid is affected by trans-cis photoisomerization which allows a fast and reversible photoinduced switching between chiral and achiral states with non-polarized light...
July 18, 2017: Angewandte Chemie
https://www.readbyqxmd.com/read/28719004/development-of-new-supramolecular-lyotropic-liquid-crystals-and-their-application-as-alignment-media-for-organic-compounds
#8
Martin Leyendecker, Nils-Christopher Meyer, Christina Thiele
Most alignment media for the residual dipolar coupling (RDC) based molecular structure determination of small organic compounds consist of rod-like polymers dissolved in organic solvents or of swollen cross-linked polymer gels. So far the synthesis of polymer based alignment media is a challenging process which is often followed by a time consuming sample preparation. We propose the use of non-polymeric alignment media based on benzene-tricarboxamides (BTA) which self-assemble into rod-like supramolecules. Our newly found supramolecular lyotropic liquid crystals (LLC) are characterized for LLC properties and their suitability as alignment medium in NMR spectroscopy...
July 18, 2017: Angewandte Chemie
https://www.readbyqxmd.com/read/28718945/efficient-paw-based-bond-strength-analysis-for-understanding-the-in-si-111-8-%C3%A3-2-4-%C3%A3-1-phase-transition
#9
Andreas Lücke, Uwe Gerstmann, Thomas D Kühne, Wolf G Schmidt
A numerically efficient yet highly accurate implementation of the crystal orbital Hamilton population (COHP) scheme for plane-wave calculations is presented. It is based on the projector-augmented wave (PAW) formalism in combination with norm-conserving pseudopotentials and allows to extract chemical interactions between atoms from band-structure calculations even for large and complex systems. The potential of the present COHP implementation is demonstrated by an in-depth analysis of the intensively investigated metal-insulator transition in atomic-scale indium wires self-assembled on the Si(111) surface...
July 18, 2017: Journal of Computational Chemistry
https://www.readbyqxmd.com/read/28718650/self-regulated-nanoparticle-assembly-at-liquid-liquid-interfaces-a-route-to-adaptive-structuring-of-liquids
#10
Caili Huang, Mengmeng Cui, Zhiwei Sun, Feng Liu, Brett A Helms, Thomas P Russell
The controlled structuring of liquids into arbitrary shapes can be achieved in biphasic liquid media using the interfacial assemblies of nanoparticle surfactants (NP-surfactants), that consist of a polar nanoparticle "head group" bound to one or more hydrophobic polymer "tails". The non-equilibrium shapes of the suspended liquid phase can be rendered permanent by the jamming of the NP-surfactants formed and assembled at the interface between the liquids as the system attempts to minimize the interfacial area between the liquids...
July 18, 2017: Langmuir: the ACS Journal of Surfaces and Colloids
https://www.readbyqxmd.com/read/28718628/synthesis-and-electrochemical-reaction-of-tin-oxalate-reduced-graphene-oxide-composite-anode-for-rechargeable-lithium-batteries
#11
Jae-Sang Park, Jae Hyeon Jo, Hitoshi Yashiro, Sung-Soo Kim, Sun-Jae Kim, Yang-Kook Sun, Seung-Taek Myung
Unlike SnO2, few studies have reported on the use of SnC2O4 as an anode material for rechargeable lithium batteries. Here, we first introduce a SnC2O4-reduced graphene oxide composite produced via hydrothermal reactions followed by a layer-by-layer self-assembly process. The addition of rGO increased the electric conductivity up to ~10-3 S cm-1. As a result, the SnC2O4-reduced graphene oxide electrode exhibited a high charge (oxidation) capacity of ~1166 mAh g-1 at a current of 100 mA g-1 (0.1 C-rate) with a good retention delivering approximately 620 mAh g-1 at the 200th cycle...
July 18, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28718479/exploring-structural-complexity-in-the-discovery-and-self-assembly-of-a-family-of-nanoscale-chalcoxides-from-se8mo36-to-se26mo68
#12
Hong-Ying Zang, Jamie W Purcell, De-Liang Long, Haralampos N Miras, Leroy Cronin
Herein, we show the controlled generation of multi-component libraries based on the [MoS2O2](2+)/Mo(VI)O4(2-)/Se(IV)O3(2-)/C4O4(2-) system leading to the formation of a whole new family of nanosized molecular chalcoxides, {Se8Mo36} 1, {Se8Mo40} 2, {Se8Mo56} 3, {Se20Mo56} 4 and {Se26Mo68} 5, of the general formula {(MoO2S2)a(OH)b(Se(IV)O3)c(C4O4)d(MoO7)e}(n-), where a, b, c, d, e, n = [16, 20, 8, 6, 2, 20] for 1, [18, 24, 8, 6, 2, 20] for 2, [24, 32, 8, 8, 4, 24] for 3, [28, 32, 20, 8, 0, 32] for 4 and [34, 36, 26, 8, 0, 36] for 5...
July 18, 2017: Chemical Communications: Chem Comm
https://www.readbyqxmd.com/read/28718292/structural-characterization-of-ordered-non-close-packed-functionalized-silica-nanoparticles-on-gold-surfaces
#13
Christian Grunewald, Madlen Schmudde, Christina Graf, Thomas Risse
Nanostructured surfaces play an important role in modern science and technology. In particular, ordered arrangements of nonclose-packed nanoparticles created by self-assembly offer a versatile route to prepare systems, which can be used in various applications such as sensing, plasmonic devices or antireflection coatings. Self-assembly based systems are particularly appealing as preparation is rather simple. The ability of nanoparticle systems to form nonclosed packed monolayers by self-assembly depends on the balance of various energetic contributions in particular the adsorption energy, the lateral barrier for diffusion and the repulsion between particles...
July 18, 2017: Langmuir: the ACS Journal of Surfaces and Colloids
https://www.readbyqxmd.com/read/28718285/strong-blue-emissive-supramolecular-self-assembly-system-based-on-naphthalimide-derivatives-and-its-ability-of-detection-and-removal-of-2-4-6-trinitrophenol
#14
Xinhua Cao, Na Zhao, Haiting Lv, Qianqian Ding, Aiping Gao, Qiangshan Jing, Tao Yi
Two simple and novel gelators (G-P with pyridine and G-B with benzene) with different C-4 substitution groups on naphthalimide derivative have been designed and characterized. Two gelators could form organogels in some solvents or mixed solvents. The self-assembly processes of G-P in mixed solvent of acetonitrile / H2O (1/1, v/v) and G-B in acetonitrile were studied by means of electron microscopy and spectroscopy. The organogel of G-P in mixed solvent of acetonitrile / H2O (1/1, v/v) formed intertwined fiber network, and its emission spectrum had obvious blue shift comparing with that of solution...
July 18, 2017: Langmuir: the ACS Journal of Surfaces and Colloids
https://www.readbyqxmd.com/read/28717800/from-molecules-to-macrostructures-recent-development-of-bioinspired-hard-tissue-repair
#15
REVIEW
Chunmei Ding, Zhuoxin Chen, Jianshu Li
Enamel, dentin and bone are calcified hard tissues in the human body that play significant roles in food mastication and movement support. Generally, hard tissues lack the ability of self-repair, except for the regeneration ability of bone for small-scale defects. Fabrication of man-made repair materials is therefore highly demanded. In this review, following a bioinspired strategy, we describe the composition and multiscale structures of different hard tissues, and highlight the key points for the reconstruction of hard tissues...
July 18, 2017: Biomaterials Science
https://www.readbyqxmd.com/read/28717350/properties-of-native-high-density-lipoproteins-inspire-synthesis-of-actively-targeted-in-vivo-sirna-delivery-vehicles
#16
Kaylin M McMahon, Michael P Plebanek, C Shad Thaxton
Efficient systemic administration of therapeutic short interfering RNA (siRNA) is challenging. High-density lipoproteins (HDL) are natural in vivo RNA delivery vehicles. Specifically, native HDLs: 1) Load single-stranded RNA; 2) Are anionic, which requires charge reconciliation between the RNA and HDL, and 3) Actively target scavenger receptor type B-1 (SR-B1) to deliver RNA. Emphasizing these particular parameters, we employed templated lipoprotein particles (TLP), mimics of spherical HDLs, and self-assembled them with single-stranded complements of, presumably, any highly unmodified siRNA duplex pair after formulation with a cationic lipid...
November 15, 2016: Advanced Functional Materials
https://www.readbyqxmd.com/read/28716960/bacterial-tubulin-a-b-exhibit-polarized-growth-mixed-polarity-bundling-and-destabilization-by-gtp-hydrolysis
#17
César Díaz-Celis, Viviana I Risca, Felipe Hurtado, Jessica K Polka, Scott D Hansen, Daniel Maturana, Rosalba Lagos, R Dyche Mullins, Octavio Monasterio
Bacteria of the genus Prosthecobacter express homologs of eukaryotic α- and β-tubulin, called BtubA and BtubB, that have been observed to assemble into filaments in presence of GTP. BtubA/B polymers are proposed to be composed in vitro by two to six protofilaments, in contrast to in vivo where they have been reported to form 5-protofilaments tubes named bacterial microtubules (bMTs). The btubAB genes likely entered the Prosthecobacter lineage via horizontal gene transfer and may derive from an early ancestor of the modern eukaryotic microtubule (MT)...
July 17, 2017: Journal of Bacteriology
https://www.readbyqxmd.com/read/28716882/protein-kinase-d-at-the-golgi-controls-nlrp3-inflammasome-activation
#18
Zhirong Zhang, Gergö Meszaros, Wan-Ting He, Yanfang Xu, Helena de Fatima Magliarelli, Laurent Mailly, Michael Mihlan, Yansheng Liu, Marta Puig Gámez, Alexander Goginashvili, Adrien Pasquier, Olga Bielska, Bénédicte Neven, Pierre Quartier, Rudolf Aebersold, Thomas F Baumert, Philippe Georgel, Jiahuai Han, Romeo Ricci
The inflammasomes are multiprotein complexes sensing tissue damage and infectious agents to initiate innate immune responses. Different inflammasomes containing distinct sensor molecules exist. The NLRP3 inflammasome is unique as it detects a variety of danger signals. It has been reported that NLRP3 is recruited to mitochondria-associated endoplasmic reticulum membranes (MAMs) and is activated by MAM-derived effectors. Here, we show that in response to inflammasome activators, MAMs localize adjacent to Golgi membranes...
July 17, 2017: Journal of Experimental Medicine
https://www.readbyqxmd.com/read/28716749/the-targeting-properties-of-folate-conjugate-pluronic-f127-poly-lactic-co-glycolic-nanoparticles
#19
Yue Yuan Luo, Xiang Yuan Xiong, Feng Cheng, Yan Chun Gong, Zi Ling Li, Yu Ping Li
Novel Folated Pluronic F127/poly (lactic-co-glycolic) (FA-F127-PLGA) and PLGA-F127-PLGA block copolymer were synthesized and nanoparticles self-assembled from these two copolymers were prepared by dialysis method. Paclitaxel (PTX) was successfully encapsulated in these two nanoparticles. According to in vitro release studies of PTX-loaded nanoparticles, after an initial burst release during the first 11h, the entrapped PTX released slowly in the following 82h. The cytotoxicity studies demonstrated that the in vitro antitumor effect of PTX could be improved by encapsulating PTX into PLGA-F127-PLGA nanoparticles...
July 14, 2017: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/28715749/self-assembly-of-zinc-hydroxystannate-on-amorphous-hydrous-tio2-solid-sphere-for-enhancing-fire-safety-of-epoxy-resin
#20
Wei Wang, Yongchun Kan, Jiajia Liu, Kim Meow Liew, Lei Liu, Yuan Hu
Zinc hydroxystannate (ZHS) was fabricated on the surface of amorphous hydrous TiO2 solid spheres (AHTSS) via a layer-by-layer method for improving the fire safety of epoxy resin. AHTSS@PEI@ZHS was prepared by self-assembly of AHTSS, PEI and ZHS. The well-organized fabrication process was proved by TEM, XPS, XRD and SEM tests. TG results illustrated that the incorporation of AHTSS@PEI@ZHS show a higher residue compared with the addition of AHTSS or ZHS alone. In addition, AHTSS@PEI@ZHS filled EP composites exhibits improved flame retardancy and smoke suppression properties evaluated by cone calorimeter test...
June 28, 2017: Journal of Hazardous Materials
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