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Self assembly

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https://www.readbyqxmd.com/read/28645043/in-vitro-and-in-vivo-behavior-of-dna-tetrahedrons-as-tumor-targeting-nanocarriers-for-doxorubicin-delivery
#1
Ji Hee Kang, Kyoung-Ran Kim, Hyukjin Lee, Dae-Ro Ahn, Young Tag Ko
Deoxyribonucleic acid (DNA) is a versatile material with high applicability and inherent biocompatibility. L-DNA, the perfect mirror form of the naturally occurring D-DNA, has been used in DNA nanotechnology. It has thermodynamically identical properties to D-DNA, is capable of self-assembly and bio-orthogonal base-pairing, and is resistant to nuclease activity. We previously constructed an L-DNA tetrahedron (L-Td) and found that this nanostructure has remarkably higher capacity for cell penetration than its natural counterpart (D-Td)...
June 16, 2017: Colloids and Surfaces. B, Biointerfaces
https://www.readbyqxmd.com/read/28644617/dynamic-covalent-chemistry-of-carbon-dioxide-opportunities-to-address-environmental-issues
#2
Jean Septavaux, Geoffroy Germain, Julien Leclaire
Extraction and purification of basic chemicals from complex mixtures has been a persistent issue throughout the development of the chemical sciences. The chemical industry and academic research have grown over the centuries by following a deconstruction-reconstruction approach, reminiscent of the metabolism process. Chemists have designed and optimized extraction, purification, and transformation processes of molecules from natural deposits (fossil fuels, biomass, ores), in order to reassemble them into complex adducts...
June 23, 2017: Accounts of Chemical Research
https://www.readbyqxmd.com/read/28644555/a-self-assembled-trigonal-prismatic-molecular-vessel-for-catalytic-dehydration-reactions-in-water
#3
Partha Sarathi Mukherjee, Paramita Das, Atul Kumar, Prodip Howlader
A water-soluble Pd6 trigonal prism (A) was synthesized by two-component coordination-driven self-assembly of a Pd(II) 90° acceptor with a tetraimidazole donor. As the walls of the prism are constructed by three conjugated aromatic building blocks, the confined pocket of the prism is hydrophobic. In addition to the hydrophobic cavity, large product egress windows make A an ideal molecular vessel to catalyze otherwise challenging pseudo multicomponent dehydration reactions in its confined nanospace in aqueous medium...
June 23, 2017: Chemistry: a European Journal
https://www.readbyqxmd.com/read/28643833/modelling-critical-casimir-force-induced-self-assembly-experiments-on-patchy-colloidal-dumbbells
#4
Arthur C Newton, T Anh Nguyen, Sandra J Veen, Daniela J Kraft, Peter Schall, Peter G Bolhuis
Colloidal particles suspended in a binary liquid mixture can interact via solvent mediated interactions, known as critical Casimir forces. For anisotropic colloids this interaction becomes directional, which leads to rich phase behavior. While experimental imaging and particle tracking techniques allow determination of isotropic effective potentials via Boltzmann inversion, the modeling of effective interaction in anisotropic systems is non-trivial precisely because of this directionality. Here we extract effective interaction potentials for non-spherical dumbbell particles from observed radial and angular distributions, by employing reference interaction site model (RISM) theory and direct Monte Carlo simulations...
June 23, 2017: Soft Matter
https://www.readbyqxmd.com/read/28643471/molecular-self-assembly-fabrication-and-carrier-dynamics-of-stable-and-efficient-ch3nh3pb-1-x-snxi3-perovskite-solar-cells
#5
Jiandong Fan, Chong Liu, Hongliang Li, Cuilin Zhang, Wenze Li, Yaohua Mai
The Sn-based perovskite solar cells (PSCs) provide the possibility that swaps the Pb element toward toxic-free PSCs. Here, we innovatively employed a molecular self-assembly approach to obtain a series CH3NH3Pb(1-x)SnxI3 (0≤x≤1) perovskite thin films with full coverage. The optimized planar CH3NH3Pb0.75Sn0.25I3 PSCs with inverted structure was consequently realized with a maximum power conversion efficiency (PCE) over 14 %, which displayed a stabilized power output (SPO) over 12 % within 200 s at 0.6 V forward bias...
June 22, 2017: ChemSusChem
https://www.readbyqxmd.com/read/28643367/facile-one-pot-synthesis-of-functional-giant-polymeric-vesicles-controlled-by-oscillatory-chemistry
#6
Bishnu Bastakoti, Juan Perez-Mercader
We introduce a novel application of an oscillatory chemical reaction to the synthesis of block copolymers. The Belousov-Zhabotinsky (B-Z) reaction is coupled with the polymerization of an amphiphilic block copolymer. Radicals generated in the B-Z reaction initiate the polymerization between a polyethylene glycol (PEG) macro reversible addition-fragmentation chain transfer agent and butyl acrylate monomers. The growth of the hydrophobic block on PEG undergoes self-assembly to form spherical micelles. The nanoscale micelles transform into submicron vesicles and grow to giant vesicles as a consequence of the oscillatory behavior of the B-Z reaction...
June 22, 2017: Angewandte Chemie
https://www.readbyqxmd.com/read/28643192/on-the-kinetics-of-body-versus-end-evaporation-and-addition-of-supramolecular-polymers
#7
Nitin S Tiwari, Paul van der Schoot
The kinetics of the self-assembly of supramolecular polymers is dictated by how monomers, dimers, trimers etc., attach to and detach from each other. It is for this reasons that researchers have proposed a plethora of pathways to explain the kinetics of various self-assembling supramolecules, including sulfur, linear micelles, living polymers and protein fibrils. Recent observations hint at the importance of a hitherto ignored molecular aggregation pathway that we refer to as "body evaporation and addition"...
June 2017: European Physical Journal. E, Soft Matter
https://www.readbyqxmd.com/read/28643001/prediction-of-self-assemblies-of-sodium-dodecyl-sulfate-and-fragrance-additives-using-coarse-grained-force-fields
#8
Chunwei Yang, Zhe Shen, Liang Wu, Haiqiu Tang, Lifeng Zhao, FengLei Cao, Huai Sun
Coarse-grained force field (CGFF) methods were applied to study the self-assembly of sodium dodecyl sulfate with fragrance additives. The CGFF parameters were parameterized and validated using experimental and all-atom simulation data. Direct molecular dynamics simulations were carried out to characterize the initial aggregation, partitioning of fragrances, and chemical potentials of the surfactant and fragrance molecules in aggregates of different sizes. The equilibrium critical micelle concentrations (CMCs) and micelle size distributions, which could not be obtained by direct simulation, were predicted using the calculated chemical potentials in combination with a thermodynamic model...
July 2017: Journal of Molecular Modeling
https://www.readbyqxmd.com/read/28642943/aqueous-dispersions-of-nanostructures-formed-through-the-self-assembly-of-iminolipids-with-exchangeable-hydrophobic-termini
#9
Wen Li, Daryl McManus, Han Liu, Cinzia Casiraghi, Simon J Webb
The addition of amines to an aldehyde surfactant, which was designed to be analogous to didodecyldimethylammonium bromide, gave exchangeable "iminolipids" that self-assembled to give stable aqueous dispersions of nano-sized vesicles. For example, sonication of suspensions of the n-hexylamine-derived iminolipid gave vesicles 50 to 200 nm in diameter that could encapsulate a water-soluble dye. The iminolipids could undergo dynamic exchange with added amines, and the resulting equilibrium constants (Krel) were quantified by (1)H NMR spectroscopy...
June 23, 2017: Physical Chemistry Chemical Physics: PCCP
https://www.readbyqxmd.com/read/28642622/self-assembled-cubic-boron-nitride-nanodots
#10
Alireza Khanaki, Zhongguang Xu, Hao Tian, Renjing Zheng, Zheng Zuo, Jian-Guo Zheng, Jianlin Liu
One of the low-dimensional Boron Nitride (BN) forms, namely, cubic-BN (c-BN) nanodots (NDs), offers a variety of novel opportunities in battery, biology, deep ultraviolet light emitting diodes, sensors, filters, and other optoelectronic applications. To date, the attempts towards producing c-BN NDs were mainly performed under extreme high-temperature/high-pressure conditions and resulted in c-BN NDs with micrometer sizes, mixture of different BN phases, and containing process-related impurities/contaminants...
June 22, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28642346/detergent-induced-self-assembly-and-controllable-photosensitizer-activity-of-diester-phenylene-ethynylenes
#11
Patrick L Donabedian, Matthew N Creyer, Florencia A Monge, Kirk S Schanze, Eva Y Chi, David G Whitten
Photodynamic therapy, in which malignant tissue is killed by targeted light exposure following administration of a photosensitizer, can be a valuable treatment modality but currently relies on passive transport and local irradiation to avoid off-target oxidation. We present a system of excited-state control for truly local delivery of singlet oxygen. An anionic phenylene ethynylene oligomer is initially quenched by water, producing minimal fluorescence and no measurable singlet oxygen generation. When presented with a binding partner, in this case an oppositely charged surfactant, changes in solvent microenvironment result in fluorescence unquenching, restoration of intersystem crossing to the triplet state, and singlet oxygen generation, as assayed by transient absorption spectroscopy and chemical trapping...
June 22, 2017: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/28642234/reconfiguration-of-dna-molecular-arrays-driven-by-information-relay
#12
Jie Song, Zhe Li, Pengfei Wang, Travis Meyer, Chengde Mao, Yonggang Ke
Information relay at the molecular level is an essential phenomenon in numerous chemical and biological processes, such as intricate signaling cascades. One key challenge in synthetic molecular self-assembly is to construct artificial structures that imitate these complex behaviors in controllable systems. We demonstrated prescribed, long-range information relay in an artificial molecular array assembled from modular DNA structural units. The dynamic DNA molecular array exhibits transformations with programmable initiation, propagation, and regulation...
June 22, 2017: Science
https://www.readbyqxmd.com/read/28641935/fatty-acid-modified-gapmer-antisense-oligonucleotide-and-serum-albumin-constructs-for-pharmacokinetic-modulation
#13
Michael Lykke Hvam, Yunpeng Cai, Frederik Dagnæs-Hansen, Jesper Sejrup Nielsen, Jesper Wengel, Jørgen Kjems, Kenneth A Howard
Delivery technologies are required for realizing the clinical potential of molecular medicines. This work presents an alternative technology to preformulated delivery systems by harnessing the natural transport properties of serum albumin using endogenous binding of gapmer antisense oligonucleotides (ASOs)/albumin constructs. We show by an electrophoretic mobility assay that fatty acid-modified gapmer and human serum albumin (HSA) can self-assemble into constructs that offer favorable pharmacokinetics. The interaction was dependent on fatty acid type (either palmitic or myristic acid), number, and position within the gapmer ASO sequence, as well as phosphorothioate (PS) backbone modifications...
June 19, 2017: Molecular Therapy: the Journal of the American Society of Gene Therapy
https://www.readbyqxmd.com/read/28641543/zein-based-nanocarriers-as-potential-natural-alternatives-for-drug-and-gene-delivery-focus-on-cancer-therapy
#14
Ahmed Elzoghby, May Freag, Hadeer Mamdouh, Kadria Elkhodairy
Protein nanocarriers possess unique merits including minimal cytotoxicity, numerous renewable sources, and high drug-binding capability. In opposition to delivery carriers utilizing hydrophilic animal proteins, hydrophobic plant proteins (e.g, zein) have great tendency in fabricating controlled-release particulate carriers without additional chemical modification to stiffen them, which in turn evades the use of toxic chemical crosslinkers. Moreover, zein is related to a class of alcohol-soluble prolamins and generally recognized as safe (GRAS) carrier for drug delivery...
June 22, 2017: Current Pharmaceutical Design
https://www.readbyqxmd.com/read/28641143/spectroscopic-and-thermodynamic-studies-of-light-harvesting-perylenediimide-derivative-zinc-porphyrin-complex-in-aqueous-media
#15
Ahmed El-Refaey, Shaban Y Shaban, Maged El-Kemary, Mohamed E El-Khouly
Self-assembly of perylene derivative such as N,N'-bis(2(trimethylammonium iodide) ethylene)perylene-3,4,9,10-tetracarboxyldiimide (TAIPDI) can produce one-dimensional form (1D) in an aqueous media. The ability of one-dimensional TAIPDI to form light harvesting complex with water-soluble zinc porphyrin (ZnTPPS4) via the π-π and electrostatic interactions has been described. Owing to electronic interactions between the π-systems, the complex formation is accompanied by pronounced absorption spectral changes in the UV/Vis absorption bands...
June 15, 2017: Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy
https://www.readbyqxmd.com/read/28640997/from-1d-polymers-to-2d-polymers-preparation-of-free-standing-single-monomer-thick-two-dimensional-conjugated-polymers-in-water
#16
Na Zhang, Taisheng Wang, Xing Wu, Chen Jiang, Taiming Zhang, Bangkun Jin, Hengxing Ji, Wei Bai, Ruke Bai
Recently, investigation on two-dimensional (2D) organic polymers has been made a great progress and conjugated 2D polymers already play a dynamic role in both academic and practical applications. However, a convenient, non-interfacial approach to obtain single-layer 2D polymers in solution, especially in aqueous media remains challenging. Herein, we present a facile, highly efficient and versatile "1D to 2D" strategy for preparation of free-standing single-monomer-thick conjugated 2D polymers in water without any aid...
June 22, 2017: ACS Nano
https://www.readbyqxmd.com/read/28640613/molecular-recognition-under-interfacial-conditions-calix-4-pyrrole-based-cross-linkable-micelles-for-ion-pair-extraction
#17
Xiaodong Chi, Gretchen Marie Peters, Forrest Hammel, Chandler Brockman, Jonathan L Sessler
An anthracene-functionalized, long-tailed calix[4]pyrrole 1, containing both an anion-recognition site and cation-recognition functionality, has been synthesized and fully characterized. Upon ion-pair complexation with FeF2, receptor 1 self-assembles into multi-micelles in aqueous media. This aggregation process is ascribed to a change in polarity from non-polar to amphiphilic induced upon concurrent anion and cation complexation and permits molecular recognition-based control over chemical morphology under interfacial conditions...
June 22, 2017: Journal of the American Chemical Society
https://www.readbyqxmd.com/read/28640536/dynamic-self-assembly-of-magnetic-polymer-composites-in-rotating-frames-of-reference
#18
Konrad Giżynski, Taehoon Lee, Bartosz A Grzybowski
Small ferromagnetic particles suspended in a rotating viscous polymer and subjected to an external static magnetic field dynamically self-assemble into open-lattice, periodic structures. Depending on the orientation of the magnetic field with respect to the system's axis of rotation, these structures range from arrays of parallel plates to single, double, triple, or even quaternary helices. Dynamic self-assembly in this rotating frame of reference can be explained by an interplay between magnetic, dipole-dipole, viscous drag, and centripetal forces...
June 22, 2017: Advanced Materials
https://www.readbyqxmd.com/read/28640482/organogelator-cellulose-composite-for-practical-and-eco-friendly-marine-oil-spill-recovery
#19
Kana M Sureshan, Annamalai Prathap
Marine oil-spills pose serious threats to the ecosystem and economy. There is much interest in developing sorbents that can tackle such spills. We have developed a novel sorbent by impregnating cellulose pulp with a sugar-derived oleogelator, 1,2:5,6-di-O-cyclohexylidene-mannitol. The gelator molecules mask the surface-exposed hydroxyl groups of cellulose fibrils by engaging them in H-bonding and expose their hydrophobic parts making the fibers temporarily hydrophobic (water contact-angle 110°). This sorbent absorbs oil effectively, selectively and instantly from oil-water mixtures due to its hydrophobicity...
June 22, 2017: Angewandte Chemie
https://www.readbyqxmd.com/read/28639790/programmable-assembly-of-peptide-amphiphile-via-noncovalent-to-covalent-bond-conversion
#20
Kohei Sato, Wei Ji, Liam C Palmer, Benjamin Weber, Matthias Barz, Samuel I Stupp
Controlling the number of monomers in a supramolecular polymer has been a great challenge in programmable self-assembly of organic molecules. One approach has been to make use of frustrated growth of the supramolecular assembly by tuning the balance of attractive and repulsive intermolecular forces. We report here on the use of covalent bond formation among monomers, compensating for intermolecular electrostatic repulsion, as a mechanism to control the length of a supramolecular nanofiber formed by self-assembly of peptide amphiphiles...
June 22, 2017: Journal of the American Chemical Society
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