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https://www.readbyqxmd.com/read/27914060/a-protocol-for-the-design-of-protein-and-peptide-nanostructure-self-assemblies-exploiting-synthetic-amino-acids
#1
Nurit Haspel, Jie Zheng, Carlos Aleman, David Zanuy, Ruth Nussinov
In recent years there has been increasing interest in nanostructure design based on the self-assembly properties of proteins and polymers. Nanodesign requires the ability to predictably manipulate the properties of the self-assembly of autonomous building blocks, which can fold or aggregate into preferred conformational states. The design includes functional synthetic materials and biological macromolecules. Autonomous biological building blocks with available 3D structures provide an extremely rich and useful resource...
2017: Methods in Molecular Biology
https://www.readbyqxmd.com/read/27913187/molecular-recognition-of-a-lipophilic-guanosine-derivative-in-langmuir-films-at-the-air-water-interface
#2
Lucija Čoga, Lea Spindler, Stefano Masiero, Irena Drevenšek-Olenik
Molecular recognition of a lipophilic deoxyguanosine derivative at the air-water interface was investigated by film balance experiments and Brewster Angle Microscopy. Results showed that guanosine, despite strong tendency towards self-assembly, interacts with both complementary and noncomplementary liponucleosides (lipophilic derivatives of deoxycytidine and deoxythymidine). At surface pressures below 17 mN/m, attractive and repulsive interactions were present in case of both mixed monolayers and were strongest at guanosine molar fractions of 0...
November 29, 2016: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/27912130/acidity-triggered-charge-convertible-nanoparticles-that-can-cause-bacterium-specific-aggregation-in-situ-to-enhance-photothermal-ablation-of-focal-infection
#3
Chiranjeevi Korupalli, Chieh-Cheng Huang, Wei-Chih Lin, Wen-Yu Pan, Po-Yen Lin, Wei-Lin Wan, Meng-Ju Li, Yen Chang, Hsing-Wen Sung
Focal infections that are caused by antibiotic-resistant bacteria are becoming an ever-growing challenge to human health. To address this challenge, a pH-responsive amphiphilic polymer of polyaniline-conjugated glycol chitosan (PANI-GCS) that can self-assemble into nanoparticles (NPs) in situ is developed. The PANI-GCS NPs undergo a unique surface charge conversion that is induced by their local pH, favoring bacterium-specific aggregation without direct contact with host cells. Following conjugation onto GCS, the optical-absorbance peak of PANI is red-shifted toward the near-infrared (NIR) region, enabling PANI-GCS NPs to generate a substantial amount of heat, which is emitted to their neighborhood...
November 24, 2016: Biomaterials
https://www.readbyqxmd.com/read/27912115/self-assembled-hemispherical-nanowell-arrays-for-superhydrophobic-antireflection-coatings
#4
Cheng-Yen Lin, Kun-Yi Andrew Lin, Ting-Wei Yang, Ying-Chu Chen, Hongta Yang
The present study reports an inexpensive and simple bottom-up technology for fabricating superhydrophobic antireflection coatings with highly ordered hemispherical nanowell structures, which are assembled by a scalable Langmuir-Blodgett technology. The subwavelength gratings lead to a gradual change in the effective refractive index, substantially suppressing specular reflection over the entire visible wavelength range. After surface modification with fluorinated silane, the resulting nanowell arrays exhibit superhydrophobic surface with high static water contact angle (154°) and low water contact angle hysteresis (7°)...
November 21, 2016: Journal of Colloid and Interface Science
https://www.readbyqxmd.com/read/27911849/scalable-manufacturing-of-biomimetic-moldable-hydrogels-for-industrial-applications
#5
Anthony C Yu, Haoxuan Chen, Doreen Chan, Gillie Agmon, Lyndsay M Stapleton, Alex M Sevit, Mark W Tibbitt, Jesse D Acosta, Tony Zhang, Paul W Franzia, Robert Langer, Eric A Appel
Hydrogels are a class of soft material that is exploited in many, often completely disparate, industrial applications, on account of their unique and tunable properties. Advances in soft material design are yielding next-generation moldable hydrogels that address engineering criteria in several industrial settings such as complex viscosity modifiers, hydraulic or injection fluids, and sprayable carriers. Industrial implementation of these viscoelastic materials requires extreme volumes of material, upwards of several hundred million gallons per year...
November 28, 2016: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/27911789/design-principles-for-nonequilibrium-self-assembly
#6
Michael Nguyen, Suriyanarayanan Vaikuntanathan
We consider an important class of self-assembly problems, and using the formalism of stochastic thermodynamics, we derive a set of design principles for growing controlled assemblies far from equilibrium. The design principles constrain the set of configurations that can be obtained under nonequilibrium conditions. Our central result provides intuition for how equilibrium self-assembly landscapes are modified under finite nonequilibrium drive.
November 22, 2016: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/27911786/geometry-induced-sequence-of-nanoscale-frank-kasper-and-quasicrystal-mesophases-in-giant-surfactants
#7
Kan Yue, Mingjun Huang, Ryan L Marson, Jinlin He, Jiahao Huang, Zhe Zhou, Jing Wang, Chang Liu, Xuesheng Yan, Kan Wu, Zaihong Guo, Hao Liu, Wei Zhang, Peihong Ni, Chrys Wesdemiotis, Wen-Bin Zhang, Sharon C Glotzer, Stephen Z D Cheng
Frank-Kasper (F-K) and quasicrystal phases were originally identified in metal alloys and only sporadically reported in soft materials. These unconventional sphere-packing schemes open up possibilities to design materials with different properties. The challenge in soft materials is how to correlate complex phases built from spheres with the tunable parameters of chemical composition and molecular architecture. Here, we report a complete sequence of various highly ordered mesophases by the self-assembly of specifically designed and synthesized giant surfactants, which are conjugates of hydrophilic polyhedral oligomeric silsesquioxane cages tethered with hydrophobic polystyrene tails...
November 28, 2016: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/27911466/transparent-nanofibrous-mesh-self-assembled-from-molecular-legos-for-high-efficiency-air-filtration-with-new-functionalities
#8
Varun Kumar Singh, Sai Kishore Ravi, Wanxin Sun, Swee Ching Tan
Alarming levels of particulate matter pollution in air pose a serious health threat in several countries, therefore intriguing a strong need for an economic and a viable technology of air filtration. Current air purification technology is rather expensive with certain types even having the risk of emitting hazardous by-products. The authors have developed a multifunctional air filter inspired from the nasal hairs possessing an ability to specifically trap/exhale the foreign particles and allergens while still letting the air flow...
December 2, 2016: Small
https://www.readbyqxmd.com/read/27910407/anisotropic-contrast-optical-microscope
#9
D Peev, T Hofmann, N Kananizadeh, S Beeram, E Rodriguez, S Wimer, K B Rodenhausen, C M Herzinger, T Kasputis, E Pfaunmiller, A Nguyen, R Korlacki, A Pannier, Y Li, E Schubert, D Hage, M Schubert
An optical microscope is described that reveals contrast in the Mueller matrix images of a thin, transparent, or semi-transparent specimen located within an anisotropic object plane (anisotropic filter). The specimen changes the anisotropy of the filter and thereby produces contrast within the Mueller matrix images. Here we use an anisotropic filter composed of a semi-transparent, nanostructured thin film with sub-wavelength thickness placed within the object plane. The sample is illuminated as in common optical microscopy but the light is modulated in its polarization using combinations of linear polarizers and phase plate (compensator) to control and analyze the state of polarization...
November 2016: Review of Scientific Instruments
https://www.readbyqxmd.com/read/27909707/in-vitro-study-of-the-host-responses-to-model-biomaterials-via-a-fibroblast-macrophage-co-culture-system
#10
Guoying Zhou, Andrea Liedmann, Chandralekha Chatterjee, Thomas Groth
Surface properties are believed to play important roles in initial inflammatory and subsequent wound healing/fibrotic responses after implantation of biomaterials. To investigate the surface property effect in mediating these host responses, we used an in vitro fibroblast/macrophage co-culture model established with a cell migration chamber, and a series of self-assembling monolayers (SAMs) bearing different terminal groups as model surfaces to study the effect of surface properties on macrophage fusion, fibroblast attachment, spreading morphology, proliferation, outgrowth, as well as pro-(interleukin-6) and anti-(interleukin-10) inflammatory cytokine production, expression of ED-A fibronectin (FN) and alpha-smooth muscle actin (α-SMA)...
December 2, 2016: Biomaterials Science
https://www.readbyqxmd.com/read/27909398/an-amyloid-like-pathological-conformation-of-tdp-43-is-stabilized-by-hypercooperative-hydrogen-bonds
#11
Miguel Mompeán, Marco Baralle, Emanuele Buratti, Douglas V Laurents
TDP-43 is an essential RNA-binding protein forming aggregates in almost all cases of sporadic amyotrophic lateral sclerosis (ALS) and many cases of frontotemporal lobar dementia (FTLD) and other neurodegenerative diseases. TDP-43 consists of a folded N-terminal domain with a singular structure, two RRM RNA-binding domains, and a long disordered C-terminal region which plays roles in functional RNA regulatory assemblies as well as pernicious aggregation. Evidence from pathological mutations and seeding experiments strongly suggest that TDP-43 aggregates are pathologically relevant through toxic gain-of-harmful-function and/or harmful loss-of-native-function mechanisms...
2016: Frontiers in Molecular Neuroscience
https://www.readbyqxmd.com/read/27908759/cathepsin-nanofiber-substrates-as-potential-agent-for-targeted-drug-delivery
#12
Yael Ben-Nun, Galit Fichman, Lihi Adler-Abramovich, Boris Turk, Ehud Gazit, Galia Blum
The development of reactive drug carriers that could actively respond to biological signals is a challenging task. Different peptides can self-assemble into biocompatible nanostructures of various functionalities, including drugs carriers. Minimal building blocks, such as diphenylalanine, readily form ordered nanostructures. Here we present development of self-assembled tetra-peptides that include the diphenylalanine motif, serving as substrates of the cathepsin proteases. This is of great clinical importance as cathepsins, whose activity and expression are highly elevated in cancer and other pathologies, have been shown to serve as efficient enzymes for therapeutic release...
November 28, 2016: Journal of Controlled Release: Official Journal of the Controlled Release Society
https://www.readbyqxmd.com/read/27907858/rapid-preparation-of-branched-and-degradable-aie-active-fluorescent-organic-nanoparticles-via-formation-of-dynamic-phenyl-borate-bond
#13
Zi Long, Meiying Liu, Liucheng Mao, Guangjian Zeng, Qing Wan, Dazhuang Xu, Fengjie Deng, Hongye Huang, Xiaoyong Zhang, Yen Wei
The fluorescent organic nanoparticles (FNPs) with aggregation-induced emission (AIE) feature have received increasing attention for their advanced optical properties. Although many efforts have been devoted to the fabrication and biomedical applications of AIE-active FNPs, the preparation of branched AIE-active FNPs with degradability through formation of dynamic bonds have rarely been reported. In this work, branched AIE-active FNPs were fabricated via dynamic linkage of hydrophobic hyperbranched and degradable Boltorn H40 (H40) with phenylboronic acid terminated AIE dye (PhB(OH)2) and mPEG (mPEG-B(OH)2), which relied on a facile one-pot strategy between phenylboronic acid and diol group of H40...
November 17, 2016: Colloids and Surfaces. B, Biointerfaces
https://www.readbyqxmd.com/read/27906398/cooperation-and-competition-between-halogen-bonding-and-van-der-waals-forces-in-supramolecular-engineering-at-the-aliphatic-hydrocarbon-graphite-interface-position-and-number-of-bromine-group-effects
#14
Bao Zha, Meiqiu Dong, Xinrui Miao, Shan Peng, Yican Wu, Kai Miao, Yi Hu, Wenli Deng
Herein, the photophysical properties of two π-conjugated thienophenanthrene derivatives (6,9- and 5,10-DBTD) are reported. Their self-assembled monolayers in aliphatic hydrocarbon solvents under different concentrations were investigated by scanning tunneling microscopy on a graphite surface. The STM results revealed that the self-assembled structures of the two geometrical isomers exhibited absolutely different behaviors. At the aliphatic solvent/graphite interface, 6,9-DBTD produced almost a single stable coassembled linear structure, except for that with n-tridecane as the solvent...
December 1, 2016: Nanoscale
https://www.readbyqxmd.com/read/27906392/multiscale-directed-self-assembly-of-composite-microgels-in-complex-electric-fields
#15
Jérôme J Crassous, Ahmet F Demirörs
This study explored the application of localized electric fields for reversible directed self-assembly of colloidal particles in 3 dimensions. Electric field microgradients, arising from the use of micro-patterned electrodes, were utilized to direct the localization and self-assembly of polarizable (charged) particles resulting from a combination of dielectrophoretic and multipolar forces. Deionized dispersions of spherical and ellipsoidal core-shell microgels were employed for investigating their assembly under an external alternating electric field...
July 5, 2016: Soft Matter
https://www.readbyqxmd.com/read/27906308/linear-and-nonlinear-optical-characterization-of-self-assembled-large-area-gold-nanosphere-metasurfaces-with-sub-nanometer-gaps
#16
Jake Fontana, Melissa Maldonado, Nicholas Charipar, Scott A Trammell, Rafaela Nita, Jawad Naciri, Alberto Pique, Banahalli Ratna, Anderson S L Gomes
We created centimeter-scale area metasurfaces consisting of a quasi-hexagonally close packed monolayer of gold nanospheres capped with alkanethiol ligands on glass substrates using a directed self-assembly approach. We experimentally characterized the morphology and the linear and nonlinear optical properties of metasurfaces. We show these metasurfaces, with interparticle gaps of 0.6 nm, are modeled well using a classical (without charge transfer) description. We find a large dispersion of linear refractive index, ranging from values less than vacuum, 0...
November 28, 2016: Optics Express
https://www.readbyqxmd.com/read/27906052/antibody-responses-to-de-novo-identified-citrullinated-fibrinogen-peptides-in-rheumatoid-arthritis-and-visualization-of-the-corresponding-b-cells
#17
Vijay Joshua, Loes Schobers, Philip J Titcombe, Lena Israelsson, Johan Rönnelid, Monika Hansson, Anca I Catrina, Ger J M Pruijn, Vivianne Malmström
BACKGROUND: Antibodies against citrullinated proteins (ACPA) are common in patients with rheumatoid arthritis (RA). ACPA can appear before disease onset and target many self-antigens. Citrullinated fibrin/fibrinogen represents a classical ACPA target antigen, and mass spectrometry of RA synovial fluid reveals elevated citrullinated (cit) fibrinogen (Fib) peptides compared to non-RA controls. We investigated the extent to which these less-studied peptides represent autoantibody targets and sought to visualize the corresponding cit-Fib-reactive B cells in RA patients...
December 1, 2016: Arthritis Research & Therapy
https://www.readbyqxmd.com/read/27905605/an-efficient-2d-11-b-11-b-solid-state-nmr-spectroscopy-strategy-for-monitoring-covalent-self-assembly-of-boronic-acid-derived-compounds-the-transformation-and-unique-architecture-of-bortezomib-molecules-in-the-solid-state
#18
J Brus, J Czernek, M Urbanova, L Kobera, A Jegorov
The difficulty in the prediction of the complicated solid-state structure of boronic acid derivatives, resulting from the complex pathway of reversible covalent interactions, represents a significant obstacle to the development of a new generation of advanced supramolecular systems such as covalent organic frameworks of efficient anticancer drugs. In this contribution, various 2D (11)B-(11)B solid-state NMR correlation techniques supported by DFT calculations were explored to formulate a reliable tool for monitoring the covalent assembly of boronic acid residues in the solid state...
December 1, 2016: Physical Chemistry Chemical Physics: PCCP
https://www.readbyqxmd.com/read/27905595/self-assembling-reactivity-and-molecular-dynamics-of-fullerenol-nanoparticles
#19
Milan Vraneš, Ivana Borišev, Aleksandar Tot, Stevan Armaković, Sanja Armaković, Danica Jović, Slobodan Gadžurić, Aleksandar Djordjevic
In this work structuring of water and insight into intermolecular interactions between water and fullerenol are studied throughout the process of forming nanoagglomerates at different temperatures applying both experimental and computational approaches. The obtained fullerenol nanoparticles (FNPs) are firstly characterized using dynamic light scattering, atomic force microscopy and transmission electron microscopy. The density, electrical conductivity and dynamic viscosity of aqueous fullerenol solutions are measured in the temperature range of 293...
December 1, 2016: Physical Chemistry Chemical Physics: PCCP
https://www.readbyqxmd.com/read/27905323/plasmonic-nano-protrusions-hierarchical-nanostructures-for-single-molecule-raman-spectroscopy
#20
Sagnik Basuray, Avinash Pathak, Sangho Bok, Biyan Chen, Steven C Hamm, Cherian J Mathai, Suchismita Guha, Keshab Gangopadhyay, Shubhra Gangopadhyay
Classical methods for enhancing the electromagnetic field from substrates for spectroscopic applications, such as surface-enhanced Raman spectroscopy (SERS), have involved the generation of hotspots through directed self-assembly of nanoparticles or by patterning nanoscale features using expensive nanolithography techniques. A novel large-area, cost-effective soft lithographic technique involving glancing angle deposition (GLAD) of silver on polymer gratings is reported here. This method produces hierarchical nanostructures with high enhancement factors capable of analyzing single-molecule SERS...
December 1, 2016: Nanotechnology
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