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https://www.readbyqxmd.com/read/28929495/the-influence-of-immune-status-age-and-sex-on-majocchi-granuloma-a-review-of-52-cases-from-a-tertiary-level-hospital-and-published-korean-cases-in-literature
#1
Jungyoon Ohn, Gwanghyun Jo, Je-Ho Mun
BACKGROUND: Majocchi granuloma (MG) is a rare dermal and subcutaneous granulomatous inflammation caused by dermatophytes. The detailed characteristics of MG are not fully elucidated. This study investigated the influence of systemic immune status, age, and sex on the clinical, demographic, mycological, and therapeutic characteristics of MG in Korea. METHODS: We analyzed cases of histopathologically diagnosed MG at our tertiary referral center from January 2001 to December 2016...
September 20, 2017: International Journal of Dermatology
https://www.readbyqxmd.com/read/28923874/agar-based-screening-for-azole-resistance-in-aspergillus-fumigatus-using-vipcheck%C3%A2-a-single-centre-evaluation
#2
J B Buil, H A L van der Lee, A J M M Rijs, J Zoll, J A M F Hovestadt, W J G Melchers, P E Verweij
Introduction Antifungal susceptibility testing is an essential tool for guiding therapy, although EUCAST and CLSI reference methods are often only available in specialized centres. We studied the performance of an agar-based screening method for the detection of azole resistance in Aspergillus fumigatus cultures.Methods The VIPcheck™ consists of four wells containing voriconazole, itraconazole, posaconazole or a growth control. Ninety-six A. fumigatus isolates were used. Thirty-three isolates harboured a known resistance mechanism: TR34/L98H (11 isolates); TR46/Y121F/T289A (6 isolates); TR53 (2 isolates) and fourteen isolates with other cyp51A-gene point mutations...
September 18, 2017: Antimicrobial Agents and Chemotherapy
https://www.readbyqxmd.com/read/28923039/a-pilot-single-centre-double-blind-placebo-controlled-randomized-parallel-study-of-calmagen%C3%A2-dermaceutical-cream-and-lotion-for-the-topical-treatment-of-tinea-and-onychomycosis
#3
Manoj Parekh, Girisha Ramaiah, Prachi Pashilkar, Ranjani Ramanujam, Peter Johnston, Leodevico L Ilag
BACKGROUND: Most of the current anti-fungal treatments are chemical-based, fungistatic, have low efficacy in the treatment of tinea and toxicity concerns, while onychomycosis remains recalcitrant to most antifungal therapies. The study aimed to establish the fungicidal, efficacy and safety profile of Calmagen® dermaceutical cream and lotion containing AMYCOT® as a topical treatment in patients with severe to very severe presentations of fungal skin (tinea) and nail infections (onychomycosis)...
September 18, 2017: BMC Complementary and Alternative Medicine
https://www.readbyqxmd.com/read/28922487/pcr-based-detection-of-a-fumigatus-and-absence-of-azole-resistance-due-to-tr34-l98h-in-a-french-multicenter-cohort-of-137-patients-with-fungal-rhinosinusitis
#4
Florent Morio, Eric Dannaoui, Taieb Chouaki, Estelle Cateau, Olivier Malard, Pierre Bonfils, Cyril Page, Xavier Dufour, Claire Cottrel, Tamic Erwan, Rose-Anne Lavergne, Patrice Le Pape
BACKGROUND: Fungal rhinosinusitis has a worldwide distribution, comprises distinct clinical entities but is mostly due to Aspergillus among which A. fumigatus plays a major role in European countries. Although, there is accumulating evidence for the emergence of environmentally acquired-azole resistance in A. fumigatus (such as TR34 /L98H) in various clinical settings, there is few data for patients with fungal rhinosinusitis. OBJECTIVES: To investigate the prevalence of A...
September 18, 2017: Mycoses
https://www.readbyqxmd.com/read/28918972/-mycological-and-parasitological-examinations-in-the-management-of-lung-infections
#5
REVIEW
L Lachaud, J P Gangneux
Pulmonary parasitic diseases are rare whereas pulmonary fungal infections are increasing. The diversity of clinical presentations requires laboratory tests to confirm the diagnosis. Direct examination of lung samples and antibody detection are the basis of parasitological diagnosis. With regard to mycoses, the range of biological tests is broader. The conventional mycological examination allows identification of any type of fungus except Pneumocystis jirovecii. Its specificity is excellent but it lacks sensitivity...
September 14, 2017: Revue des Maladies Respiratoires
https://www.readbyqxmd.com/read/28914845/-allergic-bronchopulmonary-aspergillosis-in-patients-with-asthma-results-of-a-prospective-study
#6
Ya I Kozlova, E V Frolova, L V Filippova, A E Uchevatkina, O V Aak, N N Klimko
AIM: To estimate the frequency of fungal sensitization and the incidence of allergic bronchopulmonary aspergillosis (ABPA) in asthmatic patients. SUBJECTS AND METHODS: A total of 140 asthmatic patients were examined. They underwent allergologic (skin tests for fungal allergens, estimation of total and fungal allergen-specific IgE levels) and mycological (microscopy and inoculation of respiratory biosubstrates) examinations. Chest computed tomography, when indicated, was done...
2017: Terapevticheskiĭ Arkhiv
https://www.readbyqxmd.com/read/28911040/future-research-priorities-in-fungal-resistance
#7
Matthew W McCarthy, David W Denning, Thomas J Walsh
Improved understanding of basic mycological, pharmacological, and immunological processes has led to important advances in the diagnosis and treatment of invasive fungal infections. However, the rise of fungi that are resistant to existing antifungal agents poses a substantial threat to human health. Addressing this expanding problem is an urgent priority for the international research community. In this article, we highlight important diagnostic and therapeutic advances that address the rise of resistant fungi as well as new public health initiatives that warrant further investigation to help curb the spread of these potentially lethal organisms...
August 15, 2017: Journal of Infectious Diseases
https://www.readbyqxmd.com/read/28906086/new-formulation-for-topical-treatment-of-onychomycoses
#8
Elisa M Difonzo, Federica Scarfì, Massimiliano Galeone
BACKGROUND: In order to treat onychomycosis, topical and systemic medications are available. The choice of a systemic or topic treatment depends on numerous factors, such as patient's age, the presence of comorbidity, responsible fungal species, the clinical form of onychomycosis, its location (fingernails or toenails), the number of nails affected and the percentage of the nail plate infected. As for topical medications, given that nail plate has an insufficiently permeable structure, it is necessary to use appropriate formulae that create in the surface of the nail plate a film able, in turn, to function both as an active ingredient's deposit and moisturising agent in nail's superficial layers in order to facilitate the spread of the active ingredient...
October 2017: Giornale Italiano di Dermatologia e Venereologia: Organo Ufficiale, Società Italiana di Dermatologia e Sifilografia
https://www.readbyqxmd.com/read/28905663/epidemiology-and-clinics-of-mushroom-poisoning-in-northern-italy-a-21-year-retrospective-analysis
#9
G Cervellin, I Comelli, G Rastelli, F Sanchis-Gomar, F Negri, C De Luca, G Lippi
BACKGROUND: Limited information exists about epidemiology and management of mushroom poisoning. We analyzed and described epidemiology, clinical presentation, and clinical course of mushroom-poisoned patients admitted to emergency departments (EDs) of the Province of Parma, Italy. METHODS: Data from the database of mycological service were matched with clinical information retrieved from hospitals' database, from January 1, 1996 to December 31, 2016. RESULTS: Mycologist consultation was obtained in 379/443 identified mushroom poisonings...
January 1, 2017: Human & Experimental Toxicology
https://www.readbyqxmd.com/read/28904649/harnessing-whole-genome-sequencing-in-medical-mycology
#10
REVIEW
Christina A Cuomo
PURPOSE OF REVIEW: Comparative genome sequencing studies of human fungal pathogens enable identification of genes and variants associated with virulence and drug resistance. This review describes current approaches, resources, and advances in applying whole genome sequencing to study clinically important fungal pathogens. RECENT FINDINGS: Genomes for some important fungal pathogens were only recently assembled, revealing gene family expansions in many species and extreme gene loss in one obligate species...
2017: Current Fungal Infection Reports
https://www.readbyqxmd.com/read/28903523/fungal-infections-of-the-central-nervous-system-in-children
#11
Matthew W McCarthy, Darius Kalasauskas, Vidmantas Petraitis, Ruta Petraitiene, Thomas J Walsh
Although uncommon in children, fungal infections of the central nervous system can be devastating and difficult to treat. A better understanding of basic mycologic, immunologic, and pharmacologic processes has led to important advances in the diagnosis and management of these diseases, but their mortality rates remain unacceptably high. In this focused review, we examine the epidemiology and clinical features of the most common fungal pathogens of the central nervous system in children and explore recent advances in diagnosis and antifungal therapy...
September 1, 2017: Journal of the Pediatric Infectious Diseases Society
https://www.readbyqxmd.com/read/28887005/-fungal-aetiologies-and-contributing-factors-of-interdigital-tinea-pedis-among-policemen-in-abidjan-ivory-coast
#12
P C M Kiki-Barro, A Konaté, E K Angora, F K Kassi, H Bosson-Vanga, A V Bedia-Tanoh, V Djohan, W Yavo, E I H Menan
AIM OF THE STUDY: Fungal interdigital tinea pedis are poorly documented in Ivory Coast. This study aimed to determine the distribution of fungal species and contributing factors of the disease among policemen in Abidjan. PATIENTS AND METHODS: Our cross-sectional study was carried out at the police school in Abidjan. Our patients consisted of symptomatic or non-symptomatic police students. Samples of scales or serosities taken from inter-toes spaces were examinated with KOH mount and cultured on Sabouraud-chloramphenicol and Sabouraud-chloramphenicol-actidione media...
September 5, 2017: Journal de Mycologie Médicale
https://www.readbyqxmd.com/read/28887004/-mycological-profile-of-hand-onychomycosis-amongs-garba-sellers-in-abidjan-c%C3%A3-te-d-ivoire
#13
P C M Kiki-Barro, A Konaté, F K Kassi, E K Angora, H Bosson-Vanga, A V Bedia-Tanoh, V Djohan, W Yavo, E I H Menan
OBJECTIVE: The aim of this study is to determine the prevalence and the fungi involved in onychomycosis located on fingers in Abidjan. MATERIAL AND METHODS: This study includes the sellers of cooked cassava semolina served with fried tuna fish called "garba". Fines squames specimen was processed with 30% KOH for a direct microscope examination. Serous collection were done in physiological serum. Part of the original sample was cultured on Sabouraud medium with antibiotics (chloramphénicol, actidione)...
September 5, 2017: Journal de Mycologie Médicale
https://www.readbyqxmd.com/read/28880601/onychomycosis-infectionsdo-polymerase-chain-reaction-and-culture-reports-agree
#14
Aditya K Gupta, Kerry-Ann Nakrieko
BACKGROUND: Mycological culture is the traditional method for identifying infecting agents of onychomycosis despite high false-negative results, slower processing, and complications surrounding nondermatophyte mold (NDM) infections. Molecular polymerase chain reaction (PCR) methods are faster and suited for ascertaining NDM infections. METHODS: To measure agreement between culture and PCR methods for identification of infecting species of suspected onychomycosis, single toenail samples from 167 patients and repeated serial samples from 43 patients with suspected onychomycosis were processed by culture and PCR for identification of 16 dermatophytes and five NDMs...
July 2017: Journal of the American Podiatric Medical Association
https://www.readbyqxmd.com/read/28872720/laboratory-based-investigation-of-denture-sonication-method-in-patients-with-candida-associated-denture-stomatitis
#15
Mirjana Perić, Milena Radunović, Marina Pekmezović, Jelena Marinković, Rade Živković, Valentina Arsić Arsenijević
PURPOSE: Denture stomatitis (DS) is a disease characterized by inflammation and erythema of the oral mucosa areas covered by the denture. Multifactorial etiological factors contribute to DS, but it seems that Candida plays the key role. The aim of the study was to evaluate the denture sonication method to: (i) increase the possibility of diagnosing patients with Candida-associated DS; (ii) detect and identify the mixed Candida spp., and (iii) determine the Candida colony forming units (CFU) and its possible relationship with DS severity, based on Newton's classification...
September 5, 2017: Journal of Prosthodontics: Official Journal of the American College of Prosthodontists
https://www.readbyqxmd.com/read/28872706/candida-bloodstream-infections-in-serbia-first-multi-center-report-of-a-national-prospective-observational-survey-in-intensive-care-units
#16
Valentina Arsić Arsenijević, Suzana Otašević, Dragana Janić, Predrag Minić, Jovan Matijašević, Deana Medić, Ivanka Savić, Snežana Delić, Suzana Laban Nestorović, Zorica Vasiljević, Mirjana Hadnadjev
Candida bloodstream infections (BSI) are a significant cause of mortality in intensive care units (ICU), hereof the prospective twelve-months (2014-2015) hospital and laboratory-based survey was performed at the Serbian National Reference Medical Mycology Laboratory (NRMML). Candida identification was done by a matrix-assisted laser desorption/ionization time-of-flight mass spectrometry and a susceptibility test, according to the Clinical and Laboratory Standards Institute methodology. Among 9 centers (265 beds; 10...
September 5, 2017: Mycoses
https://www.readbyqxmd.com/read/28867257/oropharyngeal-candidiasis-prevalence-among-hiv-infected-patients-at-the-teaching-hospital-of-treichville-abidjan-c%C3%A3-te-d-ivoire
#17
A Konaté, P C M Barro-Kiki, K F Kassi, K E Angora, H Vanga-Bosson, V Djohan, A V Bédia-Tanoh, A J S Miézan, W Yavo, E I H Menan
AIM OF THE STUDY: The aim of this study was to determine the mycological profile of oropharyngeal candidiasis among HIV-infected patients from Internal Medicine, Infectious and Tropical Diseases, and Pneumo-Phthisiology Diseases departments of the Teaching Hospital of Treichville in Abidjan, Côte d'Ivoire. PATIENTS AND METHODS: This was a cross-sectional study carried out on patients with lesions suggestive of oropharyngeal candidiasis from October 2010 to April 2011...
August 31, 2017: Journal de Mycologie Médicale
https://www.readbyqxmd.com/read/28858271/-the-relevance-of-candida-spp-in-chronic-periodontal-disease
#18
I N Razina, M G Chesnokova, V B Nedoseko
The aim of the study was to assess the correlation of Candida spp. incidence in periodontal tissues with various clinical manifestations of chronic periodontal disease (CPD). Ninety patients with CPD were included in the study in which Candida spp. was evaluated in periodontal pockets content and gingival biopsy material. In severe CPD more Candida spp. were seen in gingival biopsy than in periodontal pockets (p=0.0006). Candida spp. incidence and quantity correlated directly with the disease grade showing incidence increase from 40 to 73...
2017: Stomatologii︠a︡
https://www.readbyqxmd.com/read/28855482/prof-masao-ota
#19
Tomomichi Ono
Masao Ota was a Professor of Dermatology at Tokyo Imperial University. He is known to dermatologists around the world as the researcher who identified Nevus of Ota. He is also known for his research on Hansen's Disease. He was critical of the forced isolation policy and the sterilization law. He dreamt of developing chemotherapeutic measures and dedicated himself to cultivating Mycobacterium leprae. Among his accomplishments, those in the area of medical mycology are particularly remarkable. His discovery of Microsporum ferrugineum, his proposal for Trichophytia pompholyciformis, and his work on Ota-Langeron taxonomy based on the findings on fungus colonies are highly regarded and earned him the Ordre Royale de la Legion D'honneur...
2017: Medical Mycology Journal
https://www.readbyqxmd.com/read/28852411/prevalence-etiology-and-risk-factors-of-tinea-pedis-and-tinea-unguium-in-tunisia
#20
Nourchène Toukabri, Cyrine Dhieb, Dalenda El Euch, Mustapha Rouissi, Mourad Mokni, Najla Sadfi-Zouaoui
BACKGROUND: Foot mycoses are a frequent disease that represents a public health problem worldwide. OBJECTIVES: This study aims to evaluate the epidemiology of foot mycoses among Tunisian patients, in order to determine the fungal etiological agents and to identify possible risk factors. PATIENTS AND METHODS: A prospective study of three hundred and ninety-two patients was undertaken during one year (2013-2014). All subjects were asked to collect demographic data related to the risk factors of foot mycoses...
2017: Canadian Journal of Infectious Diseases & Medical Microbiology
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