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https://www.readbyqxmd.com/read/29240863/long-term-follow-up-of-onychomycosis-patients-treated-with-efinaconazole
#1
Richard A Pollak, Carla Ilie
Onychomycosis is a common disease that remains difficult to treat despite the introduction of new topical agents. Clinical trials on efinaconazole and tavaborole included 48 weeks' daily treatment regimens with a 4-week follow-up. It has been suggested that either a longer treatment regimen or longer follow-up would lead to even better results, primarily due to the time taken for the diseased nail to grow out, especially in those patients with more severe disease. <p>OBJECTIVE: To investigate the impact of a longer follow-up period on the efficacy of efinaconazole 10% topical solution in patients with moderate-to-severe onychomycosis...
December 1, 2017: Journal of Drugs in Dermatology: JDD
https://www.readbyqxmd.com/read/29191631/-clinical-problems-in-medical-mycology-problem-number-52
#2
Fernando Messina, Roxana Depardo, Ricardo Negroni, Mercedes Romero, Laura Walker, Alicia Arechavala, Emmanuel Marín, Cristina Canteros, Gabriela Santiso
The case of a 60 year old woman with hemoptysis and a thin-walled cavitary lesion at the upper lobe of the right lung is presented. The woman presented at the Mycology Unit of the Muñiz Hospital in Buenos Aires City 3 months after the beginning of her clinical manifestations. A hyaline micelial fungus with chlamido-arthroconidias was isolated from the bronchoalveolar lavage. Immunodiffusion and counter-immnunoelectrophoresis with coccidioidin and histoplasmin rendered positive results against both antigents, and skin tests with coccidioidin and histoplasmin were also positive with strong reactions...
November 27, 2017: Revista Iberoamericana de Micología
https://www.readbyqxmd.com/read/29187717/-a-case-of-liver-dysfunction-requiring-hospital-admission-after-taking-oral-itraconazole-for-the-treatment-of-kerion-celsi
#3
Eri Ikeda, Soko Watanabe, Mizuki Sawada, Junya Ninomiya, Itaru Dekio, Sumiko Ishizaki, Mariko Fujibayashi, Masaru Tanaka, Takashi Harada
  67-year-old female patient developed drug-induced liver dysfunction after taking oral itraconazole (ITCZ) for the treatment of kerion celsi. Red papules appeared on the temporal area of the patient one month prior to her visit to our clinic. The patient presented with a nodule with yellow crust, erosion, infiltration, and hair loss on the area. Diagnosis of kerion celsi caused by Trichophyton rubrum was made from clinical, pathological, and mycological findings. Laboratory data showed normal liver function, and the patient was not taking any other medication, thus, daily oral ITCZ 100 mg was started...
2017: Medical Mycology Journal
https://www.readbyqxmd.com/read/29169813/-clinical-problems-in-medical-mycology-problem-number-51
#4
Mercedes Romero, Fernando Messina, Emmanuel Marín, Alicia Arechavala, Ricardo Negroni, Roxana Depardo, Laura Walker, Andrés Benchetrit, Gabriela Santiso
A 48 year-old immunocompetent woman, who had a nodular lesion in the neck and a dense infiltrate at the lower lobe of the left lung, presented at the Mycology Unit of Muñiz Hospital of Buenos Aires City. The pulmonary infiltrate disappeared spontaneously 3 months later. The histopathological study of the nodular lesion showed capsulated yeasts (mucicarmin and alcian blue positive stains) compatible with Cryptococcus. The mycological study of a new sample, obtained by a nodular puncture, allowed the isolation of yeasts, identified as Cryptococcus gattii (VGII)...
November 20, 2017: Revista Iberoamericana de Micología
https://www.readbyqxmd.com/read/29168557/probiotics-for-vulvovaginal-candidiasis-in-non-pregnant-women
#5
REVIEW
Huan Yu Xie, Dan Feng, Dong Mei Wei, Ling Mei, Hui Chen, Xun Wang, Fang Fang
BACKGROUND: Vulvovaginal candidiasis (VVC) is estimated to be the second most common form of infection after bacterial vaginosis. The ability of probiotics in maintaining and recovering the normal vaginal microbiota, and their potential ability to resist Candidas give rise to the concept of using probiotics for the treatment of VVC. OBJECTIVES: To assess the effectiveness and safety of probiotics for the treatment of vulvovaginal candidiasis in non-pregnant women...
November 23, 2017: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/29157206/antifungal-susceptibility-testing-of-candida-species-isolated-from-the-immunocompromised-patients-admitted-to-ten-university-hospitals-in-iran-comparison-of-colonizing-and-infecting-isolates
#6
Parisa Badiee, Hamid Badali, Teun Boekhout, Kambiz Diba, Abdolkarim Ghadimi Moghadam, Ali Hossaini Nasab, Hadis Jafarian, Rasoul Mohammadi, Hossein Mirhendi, Mohammad Javad Najafzadeh, Ahmad Shamsizadeh, Jafar Soltani
BACKGROUND: Antifungal susceptibility testing is a subject of interest in the field of medical mycology. The aim of the present study were the distributions and antifungal susceptibility patterns of various Candida species isolated from colonized and infected immunocompromised patients admitted to ten university hospitals in Iran. METHODS: In totally, 846 Candida species were isolated from more than 4000 clinical samples and identified by the API 20 C AUX system...
November 21, 2017: BMC Infectious Diseases
https://www.readbyqxmd.com/read/29132742/-statement-in-favor-of-the-foundation-of-the-iberoamerican-society-for-medical-mycology
#7
Guillermo Quindós, Javier Pemán
No abstract text is available yet for this article.
October 2017: Revista Iberoamericana de Micología
https://www.readbyqxmd.com/read/29108709/update-on-actinomucor-elegans-a-mucormycete-infrequently-detected-in-human-specimens-how-combined-microbiological-tools-contribute-efficiently-to-a-more-accurate-medical-care
#8
J Dorin, M D'Aveni, A Debourgogne, M Cuenin, M Guillaso, A Rivier, P Gallet, G Lecoanet, M Machouart
Actinomucor elegans is a fungus belonging to mucormycetes and is still probably underdiagnosed due to misidentification. Based on a recent first case of Actinomucor elegans sinusitis in Europe, in an immunocompromised patient under voriconazole treatment, this paper aims to summarize knowledge about A. elegans mucormycoses. Even if the diagnosis of mucormycosis was made using traditional mycology techniques, precise identification of the fungus could only be achieved using molecular tools. In this observation, the galactomannan dosage was positive until the introduction of treatment and surgical debridement...
October 26, 2017: International Journal of Medical Microbiology: IJMM
https://www.readbyqxmd.com/read/29082256/examination-of-oral-microbiota-diversity-in-adults-and-older-adults-as-an-approach-to-prevent-spread-of-risk-factors-for-human-infections
#9
Paweł J Zawadzki, Konrad Perkowski, Marcin Padzik, Elżbieta Mierzwińska-Nastalska, Jacek P Szaflik, David Bruce Conn, Lidia Chomicz
The oral cavity environment may be colonized by polymicrobial communities with complex, poorly known interrelations. The aim of this study was to determine oral microbiota diversity in order to prevent the spread of infectious microorganisms that are risk factors for human health complications in patients requiring treatment due to various disabilities. The study examined Polish adults aged between 40 and 70 years; parasitological, microbiological, and mycological data collected before treatment were analyzed...
2017: BioMed Research International
https://www.readbyqxmd.com/read/29027030/diagnostic-accuracy-of-fungal-identification-in-histopathology-and-cytopathology-specimens
#10
V L Kung, R D Chernock, C-A D Burnham
Tools to diagnose fungal infection are microscopic examination, antigen or antibody-based detection tests, molecular diagnostics, and culture, with culture being the "gold standard" for species-level identification. Although these methods are commonly used in concert and yield concordant results, in some cases tissue is not available for culture, and/or different methodologies yield discrepant results. These discrepancies may be clinically significant, causing confusion and inappropriate or delayed initiation of antifungals...
October 13, 2017: European Journal of Clinical Microbiology & Infectious Diseases
https://www.readbyqxmd.com/read/28959791/clinical-features-diagnosis-and-outcomes-of-rhino-orbito-cerebral-mucormycosis-a-retrospective-analysis
#11
A Abdollahi, T Shokohi, N Amirrajab, R Poormosa, A M Kasiri, S J Motahari, S M Ghoreyshi, S A Madani, M Nikkhah, M Ghasemi, L Vahedi Larijani, M Didehdar, Z Seifi, N Gholinejad, M Ilkit
BACKGROUND AND PURPOSE: Rhino-orbito-cerebral mucormycosis (ROCM) is a rare disease with acute and fulminant manifestation. This infection is associated with high morbidity and mortality rates. Herein, we reviewed the manifestations, underlying conditions, medical treatments, and surgical interventions in ROCM patients admitted to a tertiary referral center in northern Iran over a seven-year period. MATERIALS AND METHODS: In a retrospective analysis, 15 cases of ROCM were identified from 2007 to 2013 in Bu Ali Sina Hospital, Sari, Iran...
December 2016: Advances in Medical Mycology (Iran)
https://www.readbyqxmd.com/read/28949416/8th-trends-in-medical-mycology-organised-under-the-auspices-of-eortc-idg-and-ecmm-6-9-october-2017-belgrade-serbia
#12
(no author information available yet)
No abstract text is available yet for this article.
September 2017: Mycoses
https://www.readbyqxmd.com/read/28922487/pcr-based-detection-of-a-fumigatus-and-absence-of-azole-resistance-due-to-tr34-l98h-in-a-french-multicenter-cohort-of-137-patients-with-fungal-rhinosinusitis
#13
Florent Morio, Eric Dannaoui, Taieb Chouaki, Estelle Cateau, Olivier Malard, Pierre Bonfils, Cyril Page, Xavier Dufour, Claire Cottrel, Tamic Erwan, Rose-Anne Lavergne, Patrice Le Pape
BACKGROUND: Fungal rhinosinusitis has a worldwide distribution, comprises distinct clinical entities but is mostly due to Aspergillus among which A. fumigatus plays a major role in European countries. Although, there is accumulating evidence for the emergence of environmentally acquired-azole resistance in A. fumigatus (such as TR34 /L98H) in various clinical settings, there is few data for patients with fungal rhinosinusitis. OBJECTIVES: To investigate the prevalence of A...
September 18, 2017: Mycoses
https://www.readbyqxmd.com/read/28906086/new-formulation-for-topical-treatment-of-onychomycoses
#14
Elisa M Difonzo, Federica Scarfì, Massimiliano Galeone
BACKGROUND: In order to treat onychomycosis, topical and systemic medications are available. The choice of a systemic or topic treatment depends on numerous factors, such as patient's age, the presence of comorbidity, responsible fungal species, the clinical form of onychomycosis, its location (fingernails or toenails), the number of nails affected and the percentage of the nail plate infected. As for topical medications, given that nail plate has an insufficiently permeable structure, it is necessary to use appropriate formulae that create in the surface of the nail plate a film able, in turn, to function both as an active ingredient's deposit and moisturising agent in nail's superficial layers in order to facilitate the spread of the active ingredient...
October 2017: Giornale Italiano di Dermatologia e Venereologia: Organo Ufficiale, Società Italiana di Dermatologia e Sifilografia
https://www.readbyqxmd.com/read/28904649/harnessing-whole-genome-sequencing-in-medical-mycology
#15
REVIEW
Christina A Cuomo
PURPOSE OF REVIEW: Comparative genome sequencing studies of human fungal pathogens enable identification of genes and variants associated with virulence and drug resistance. This review describes current approaches, resources, and advances in applying whole genome sequencing to study clinically important fungal pathogens. RECENT FINDINGS: Genomes for some important fungal pathogens were only recently assembled, revealing gene family expansions in many species and extreme gene loss in one obligate species...
2017: Current Fungal Infection Reports
https://www.readbyqxmd.com/read/28872706/candida-bloodstream-infections-in-serbia-first-multi-center-report-of-a-national-prospective-observational-survey-in-intensive-care-units
#16
Valentina Arsić Arsenijević, Suzana Otašević, Dragana Janić, Predrag Minić, Jovan Matijašević, Deana Medić, Ivanka Savić, Snežana Delić, Suzana Laban Nestorović, Zorica Vasiljević, Mirjana Hadnadjev
Candida bloodstream infections (BSI) are a significant cause of mortality in intensive care units (ICU), hereof the prospective twelve-months (2014-2015) hospital and laboratory-based survey was performed at the Serbian National Reference Medical Mycology Laboratory (NRMML). Candida identification was done by a matrix-assisted laser desorption/ionization time-of-flight mass spectrometry and a susceptibility test, according to the Clinical and Laboratory Standards Institute methodology. Among 9 centers (265 beds; 10...
September 5, 2017: Mycoses
https://www.readbyqxmd.com/read/28855482/prof-masao-ota
#17
Tomomichi Ono
Masao Ota was a Professor of Dermatology at Tokyo Imperial University. He is known to dermatologists around the world as the researcher who identified Nevus of Ota. He is also known for his research on Hansen's Disease. He was critical of the forced isolation policy and the sterilization law. He dreamt of developing chemotherapeutic measures and dedicated himself to cultivating Mycobacterium leprae. Among his accomplishments, those in the area of medical mycology are particularly remarkable. His discovery of Microsporum ferrugineum, his proposal for Trichophytia pompholyciformis, and his work on Ota-Langeron taxonomy based on the findings on fungus colonies are highly regarded and earned him the Ordre Royale de la Legion D'honneur...
2017: Medical Mycology Journal
https://www.readbyqxmd.com/read/28840426/human-infections-with-microsporum-gypseum-complex-nannizzia-gypsea-in-slovenia
#18
Mateja Dolenc-Voljč, Jurij Gasparič
Microsporum gypseum complex is a group of geophillic dermatophytes with a worldwide distribution and is a rare cause of dermatomycoses in humans. The infection most commonly presents as tinea corporis, with some geographical and occupational variations. We studied M. gypseum complex infections in patients examined in the Mycological Laboratory of the Department of Dermatovenereology, University Medical Centre Ljubljana, during the period 2000-2015. Diagnosis was confirmed by mycological examination. Skin scales were examined by direct microscopy and cultivated on Sabouraud glucose agar...
December 2017: Mycopathologia
https://www.readbyqxmd.com/read/28828321/dicrocoelium-egg-identified-in-an-ancient-cemetery-in-kiasar-archeological-site-northern-iran-dated-back-247-bc-224-ad
#19
Negar Bizhani, Abdol Motalleb Sharifi, Mohmmad Bagher Rokni, Jean Dupouy Camet, Mostafa Rezaeian, Mohammad Fallah Kiapi, Niloofar Paknezhad, Faezeh Najafi, Gholamreza Mowlavi
BACKGROUND: Along with the newly emergence of paleoparasitology research in Iran, findings of parasites from Northern part of the county have not been reported so far. In this study tracking for the lancet liver fluke dates back 250 BC is addressed. METHODS: Samples were taken from grave crypts of the soil layers attached to the pelvic bones from above-mentioned site in 2015. The laboratory examinations were conducted in the Dept. of Medial Parasitology and Mycology, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran...
June 2017: Iranian Journal of Public Health
https://www.readbyqxmd.com/read/28804700/abridged-version-of-the-awmf-guideline-for-the-medical-clinical-diagnostics-of-indoor-mould-exposure-s2k-guideline-of-the-german-society-of-hygiene-environmental-medicine-and-preventive-medicine-ghup-in-collaboration-with-the-german-association-of-allergists
#20
Gerhard A Wiesmüller, Birger Heinzow, Ute Aurbach, Karl-Christian Bergmann, Albrecht Bufe, Walter Buzina, Oliver A Cornely, Steffen Engelhart, Guido Fischer, Thomas Gabrio, Werner Heinz, Caroline E W Herr, Jörg Kleine-Tebbe, Ludger Klimek, Martin Köberle, Herbert Lichtnecker, Thomas Lob-Corzilius, Rolf Merget, Norbert Mülleneisen, Dennis Nowak, Uta Rabe, Monika Raulf, Hans Peter Seidl, Jens-Oliver Steiß, Regine Szewszyk, Peter Thomas, Kerttu Valtanen, Julia Hurraß
This article is an abridged version of the AWMF mould guideline "Medical clinical diagnostics of indoor mould exposure" presented in April 2016 by the German Society of Hygiene, Environmental Medicine and Preventive Medicine (Gesellschaft für Hygiene, Umweltmedizin und Präventivmedizin, GHUP), in collaboration with the above-mentioned scientific medical societies, German and Austrian societies, medical associations and experts. Indoor mould growth is a potential health risk, even if a quantitative and/or causal relationship between the occurrence of individual mould species and health problems has yet to be established...
2017: Allergo Journal International
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