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Medical mycology

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https://www.readbyqxmd.com/read/28332720/efficacy-and-safety-of-luliconazole-5-nail-solution-for-the-treatment-of-onychomycosis-a-multicenter-double-blind-randomized-phase-iii-study
#1
Shinichi Watanabe, Hiroshi Kishida, Akihiro Okubo
Onychomycosis is a highly prevalent and intractable disease. The first-line treatment agents are oral preparations, but an effective topical medication has long been desired. The objective was to investigate the efficacy and safety of luliconazole 5% nail solution, an imidazole antifungal agent, for the treatment of patients with onychomycosis. A multicenter, double-blind, randomized phase III study was conducted in Japanese patients with distal lateral subungual onychomycosis affecting the great toenails, with 20-50% clinical involvement...
March 23, 2017: Journal of Dermatology
https://www.readbyqxmd.com/read/28314677/vulvovaginal-candidiasis-etiology-symptomatology-and-risk-factors
#2
L Mtibaa, N Fakhfakh, A Kallel, S Belhadj, N Belhaj Salah, N Bada, K Kallel
OBJECTIVE: To determine epidemiological, clinical and mycological characteristics of vulvovaginal candidiasis (VVC) in Tunisian population and to evaluate predisposing factors. PATIENTS AND METHODS: In this retrospective study, 2160 vaginal swabs were performed over 2 years (January 2014-December 2015). It was carried out at the laboratory of Parasitology and Mycology, Rabta Hospital in Tunisia. After swab collecting, direct examination and culture on Sabouraud Chloramphenicol and Sabouraud Chloramphenicol Actidione media were implemented to research yeasts...
March 14, 2017: Journal de Mycologie Médicale
https://www.readbyqxmd.com/read/28298477/central-role-of-the-trehalose-biosynthesis-pathway-in-the-pathogenesis-of-human-fungal-infections-opportunities-and-challenges-for-therapeutic-development
#3
REVIEW
Arsa Thammahong, Srisombat Puttikamonkul, John R Perfect, Richard G Brennan, Robert A Cramer
Invasive fungal infections cause significant morbidity and mortality in part due to a limited antifungal drug arsenal. One therapeutic challenge faced by clinicians is the significant host toxicity associated with antifungal drugs. Another challenge is the fungistatic mechanism of action of some drugs. Consequently, the identification of fungus-specific drug targets essential for fitness in vivo remains a significant goal of medical mycology research. The trehalose biosynthetic pathway is found in a wide variety of organisms, including human-pathogenic fungi, but not in humans...
June 2017: Microbiology and Molecular Biology Reviews: MMBR
https://www.readbyqxmd.com/read/28294418/a-critical-review-of-improvement-rates-for-laser-therapy-used-to-treat-toenail-onychomycosis
#4
REVIEW
A K Gupta, S G Versteeg
BACKGROUND: Onychomycosis is a nail infection that is primary caused by dermatophytes. Alternative treatments are needed as current therapies (oral and topical antifungals) have limited effectiveness. Lasers are currently approved by the FDA to temporarily increase the amount of clear nail in onychomycosis patients. Lasers can theoretically elicit fungicidal effects but in practice produce mixed results. OBJECTIVE: This review compares laser-induced improvement rates to FDA approved indications and traditional onychomycosis treatments...
March 13, 2017: Journal of the European Academy of Dermatology and Venereology: JEADV
https://www.readbyqxmd.com/read/28080988/medical-mycology-and-fungal-immunology-new-research-perspectives-addressing-a-major-world-health-challenge
#5
REVIEW
Neil A R Gow, Mihai G Netea
Fungi cause more than a billion skin infections, more than 100 million mucosal infections, 10 million serious allergies and more than a million deaths each year. Global mortality owing to fungal infections is greater than for malaria and breast cancer and is equivalent to that owing to tuberculosis (TB) and HIV. These statistics evidence fungal infections as a major threat to human health and a major burden to healthcare budgets worldwide. Those patients who are at greatest risk of life-threatening fungal infections include those who have weakened immunity or have suffered trauma or other predisposing infections such as HIV...
December 5, 2016: Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences
https://www.readbyqxmd.com/read/28035615/epidemio-clinico-microbiological-study-of-mycotic-keratitis-in-north-west-region-of-rajasthan
#6
Abhishek Binnani, Priyanka Soni Gupta, Ankur Gupta
AIM AND OBJECTIVES: Mycotic keratitis, with its diverse clinical presentation and difficulties in treatment, makes it a challenging task for clinicians and an important object of study. The aim of present study was to determine the frequency of occurrence and epidemiological association with identification of fungal isolates from mycotic keratitis cases. MATERIALS AND METHODS: This was a prospective and observational study conducted in Mycology Laboratory, Department of Microbiology, S...
December 29, 2016: Mycopathologia
https://www.readbyqxmd.com/read/27910139/characterization-of-patients-with-chronic-pulmonary-aspergillosis-according-to-the-new-escmid-ers-ecmm-and-idsa-guidelines
#7
COMPARATIVE STUDY
Helmut J F Salzer, Jan Heyckendorf, Barbara Kalsdorf, Thierry Rolling, Christoph Lange
Recently, the Infectious Diseases Society of America (IDSA) and the European Society for Clinical Microbiology and Infectious Diseases (ESCMID) in cooperation with the European Respiratory Society (ERS) and the European Confederation of Medical Mycology (ECMM) published guidelines for the diagnosis of chronic pulmonary aspergillosis (CPA). Both guidelines, however, carry significant differences. We retrospectively applied the diagnostic recommendations on a patient cohort of 71 previously diagnosed CPA patients in order to compare both guidelines...
February 2017: Mycoses
https://www.readbyqxmd.com/read/27858846/the-efficacy-of-fractional-carbon-dioxide-co2-laser-combined-with-luliconazole-1-cream-for-the-treatment-of-onychomycosis-a-randomized-controlled-trial
#8
RANDOMIZED CONTROLLED TRIAL
Bing Rong Zhou, Yan Lu, Felicia Permatasari, He Huang, Jin Li, Juan Liu, Jia An Zhang, Dan Luo, Yang Xu
BACKGROUND: To evaluate the efficacy of fractional carbon dioxide (CO2) laser combined with luliconazole 1% cream for the treatment of onychomycosis and to compare it with that of fractional CO2 laser alone. METHODS: This was a randomized, parallel group, 2-arm, positive-controlled, single-center, superiority trial with a 1:2 allocation ratio. Sixty patients with clinical and mycological diagnosis of onychomycosis were enrolled from the Dermatology Department of the First Affiliated Hospital of Nanjing Medical University in Nanjing, China from March 2015 to May 2015...
November 2016: Medicine (Baltimore)
https://www.readbyqxmd.com/read/27856701/40-years-of-medical-mycology-at-jac
#9
REVIEW
Luis Ostrosky-Zeichner
In the past 40 years, medical mycology has gone from a curiosity in the basements of medical schools to a mainstream branch of clinical microbiology and infectious diseases. Long gone are the days of carefully curated collections of organisms identified purely based on morphology and skill, the lack of therapeutic interventions beyond amphotericin B and the occasional strange case in the ward of a diabetic patient with mucormycosis. We highlight advances in medical mycology as reflected in the past 40 years of JAC...
December 2016: Journal of Antimicrobial Chemotherapy
https://www.readbyqxmd.com/read/27843740/verification-of-ribosomal-proteins-of-aspergillus-fumigatus-for-use-as-biomarkers-in-maldi-tof-ms-identification
#10
Sayaka Nakamura, Hiroaki Sato, Reiko Tanaka, Takashi Yaguchi
We have previously proposed a rapid identification method for bacterial strains based on the profiles of their ribosomal subunit proteins (RSPs), observed using matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI-TOF MS). This method can perform phylogenetic characterization based on the mass of housekeeping RSP biomarkers, ideally calculated from amino acid sequence information registered in public protein databases. With the aim of extending its field of application to medical mycology, this study investigates the actual state of information of RSPs of eukaryotic fungi registered in public protein databases through the characterization of ribosomal protein fractions extracted from genome-sequenced Aspergillus fumigatus strains Af293 and A1163 as a model...
2016: Mass Spectrometry
https://www.readbyqxmd.com/read/27815496/lasers-for-onychomycosis
#11
Aditya K Gupta, Kelly A Foley, Sarah G Versteeg
Many studies that have been recently published investigate the efficacy of laser treatment for onychomycosis. These studies support the current US Food and Drug Administration (FDA) approval of lasers for the 'temporary increase in clear nail'. Clear nail growth is an important treatment goal for patients; however, many do not realise that laser treatment is not a cure for onychomycosis. The current article briefly reviews why lasers may be theoretically effective in treating onychomycosis and critically reviews published laser studies for onychomycosis in light of the standards employed in drug trials...
March 2017: Journal of Cutaneous Medicine and Surgery
https://www.readbyqxmd.com/read/27800138/growing-incidence-of-non-dermatophyte-onychomycosis-in-tehran-iran
#12
Marjan Motamedi, Zeinab Ghasemi, Mohammad Reza Shidfar, Leila Hosseinpour, Hossein Khodadadi, Kamiar Zomorodian, Hossein Mirhendi
BACKGROUND: Non-dermatophyte onychomycosis (NDO) is caused by a wide range of mold fungi other than dermatophytes, and has been reported at various rates in different countries worldwide. Studies on the incidence of NDO in the community are essential for understanding its epidemiology and control, as well as for the appropriate treatment of these infections. OBJECTIVES: In this study, the incidence of NDO in Tehran, Iran, was compared to the incidence of onychomycoses due to dermatophytes and yeasts...
August 2016: Jundishapur Journal of Microbiology
https://www.readbyqxmd.com/read/27790797/causative-agents-of-onychomycosis-a-7-year-study
#13
Mostafa Chadeganipour, Rasoul Mohammadi
BACKGROUND: Onychomycosis is principally caused by dermatophyte species, but nondermatophyte molds and yeasts have also been involved, causing different clinical manifestations. The aim of this investigation is to determine the clinicomycological and epidemiological profile of the etiologic agents of onychomycosis. METHODS: The study population included 9,785 suspected cases of onychomycosis referred to the Medical Mycology Reference Laboratory in Isfahan, Iran, during 2007-2014...
November 2016: Journal of Clinical Laboratory Analysis
https://www.readbyqxmd.com/read/27790435/mycological-profile-of-sputum-of-hiv-positive-patients-with-lower-respiratory-tract-infection-and-its-correlation-with-cd4-t-lymphocyte-count
#14
Jyotsna Chandwani, Nitya Vyas, Saroj Hooja, Babita Sharma, Rakesh Maheshwari
INTRODUCTION: Fungal respiratory infections are important cause of mortality and morbidity among HIV positive individuals. They account for up to 70% of illness in Acquired Immunodeficiency Disease Syndrome cases (AIDS). The range of illness varies from asymptomatic mucosal candidiasis to overwhelming disseminated infections. In these patients dissemination of fungus leads to very serious outcomes hence, it is important to have the knowledge of prevailing profile of fungus causing infections, so that it can be treated at the onset...
September 2016: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/27730797/pioneers-in-medical-mycology-and-mycobacteriology
#15
Preeti Pillai, Mahesh Lakhe, Anjali Shetty, Rajeev Soman
No abstract text is available yet for this article.
February 2016: Journal of the Association of Physicians of India
https://www.readbyqxmd.com/read/27703021/aspergillus-antibody-detection-diagnostic-strategy-and-technical-considerations-from-the-soci%C3%A3-t%C3%A3-fran%C3%A3-aise-de-mycologie-m%C3%A3-dicale-french-society-for-medical-mycology-expert-committee
#16
F Persat, C Hennequin, J P Gangneux
Until now, there has been no consensus on the best method for the detection of anti-Aspergillus antibodies, a key diagnostic tool for chronic aspergilloses. To better appreciate the usage of and confidence in these techniques, the Société Française de Mycologie Médicale (French Society for Medical Mycology; SFMM) performed a two-step survey of French experts. First, we administered an initial survey to French labs performing Aspergillus serology to depict usage of the different techniques available for Aspergillus serology...
October 4, 2016: Medical Mycology: Official Publication of the International Society for Human and Animal Mycology
https://www.readbyqxmd.com/read/27648562/introducing-mushroom-fruiting-patterns-from-the-swiss-national-poisons-information-centre
#17
Katharina M Schenk-Jäger, Simon Egli, David Hanimann, Beatrice Senn-Irlet, Hugo Kupferschmidt, Ulf Büntgen
Changes in the ecology of macrofungi are poorly understood, not only because much of their life cycle is hidden belowground, but also because experiments often miss real-world complexity and most fruitbody inventories are limited in space and time. The National Poisons Information Centre 'Tox Info Suisse' provides countrywide 24hours/7days medical advice in case of poisonings since 1966. Here, we introduce a total of 12,126 mushroom-related phone calls that were received by Tox Info Suisse between 1966 and 2014...
2016: PloS One
https://www.readbyqxmd.com/read/27581779/mycological-education-for-dermatologists
#18
Katsutaro Nishimoto
Mycotic infections remain important in dermatological clinics. Therefore the mycological training curriculum needs to be reorganized starting from the beginning of dermatological education, including routine examination procedures, such as potassium hydroxide examination, culture of pathogenic fungi, histopathology, treatment guidelines, and the recent advances in medical mycology.Several mycological institutes will be selected and announced in the journal to provide support for mycological examinations and to publish important cases treated in clinics...
2016: Medical Mycology Journal
https://www.readbyqxmd.com/read/27581775/studies-in-phylogeny-development-of-rapid-identificationmethods-antifungal-susceptibility-and-growth-rates-of-clinical-strains-of-sporothrix-schenckii-complex-in-japan
#19
Rumi Suzuki, Alimu Yikelamu, Reiko Tanaka, Ken Igawa, Hiroo Yokozeki, Takashi Yaguchi
Sporotrichosis is a fungal infection caused by the Sporothrix species, which have distinct virulence profiles and geographic distributions. We performed a phylogenetic study in strains morphologically identified as Sporothrix schenckii from clinical specimens in Japan, which were preserved at the Medical Mycology Research Center, Chiba University. In addition, we examined the in vitro antifungal susceptibility and growth rate to evaluate their physiological features. Three hundred strains were examined using sequence analysis of the partial calmodulin gene, or polymerase chain reaction(PCR)method using newly designed species-specific primers; 291 strains were Sporothrix globosa and 9 strains were S...
2016: Medical Mycology Journal
https://www.readbyqxmd.com/read/27579738/nail-abnormalities-in-patients-with-vitiligo
#20
Ilteris Oguz Topal, Sule Gungor, Ozgur Emek Kocaturk, Hatice Duman, Mustafa Durmuscan
BACKGROUND: Vitiligo is an acquired pigmentary skin disorder affecting 0.1-4% of the general population. The nails may be affected in patients with an autoimmune disease such as psoriasis, and in those with alopecia areata. It has been suggested that nail abnormalities should be apparent in vitiligo patients. OBJECTIVE: We sought to document the frequency and clinical presentation of nail abnormalities in vitiligo patients compared to healthy volunteers. We also examined the correlations between nail abnormalities and various clinical parameters...
July 2016: Anais Brasileiros de Dermatologia
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