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Candida spp.

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https://www.readbyqxmd.com/read/28641558/bis-2-aminoimidazolines-and-bisguanidines-synthetic-approaches-antiparasitic-activity-and-dna-binding-properties
#1
Christophe Dardonville, J Jonathan Nué Martínez
BACKGROUND: Parasitic diseases caused by protozoan parasites of the genus Trypanosoma and Plasmodium cause some of the deadliest and disabling human infections in tropical and subtropical areas. Diphenyl-based bis(2-phenylimino)imidazolidines and bisguanidines are extremely potent antiparasitic agents against Trypanosoma brucei (etiological agent of African trypanosomiasis) and Plasmodium falciparum (etiological agent of severe malaria). Many of these compounds are also curative in mouse models of stage 1 African trypanosomiasis representing promising leads for the development of antitrypanosomal drugs...
June 22, 2017: Current Medicinal Chemistry
https://www.readbyqxmd.com/read/28640920/pathogen-specific-mortality-in-very-low-birth-weight-infants-with-primary-bloodstream-infection
#2
Brar C Piening, Christine Geffers, Petra Gastmeier, Frank Schwab
OBJECTIVE: Mortality in very low birth weight infants following microbiology confirmed primary bloodstream infections varies with the type of causative pathogen. Given evidence from other studies that infections with gram negative bacteria and fungi cause a higher case fatality risk. We tried to confirm this in a nation-wide multi-center trial. METHODS: A cohort of 55,465 very low birth weight infants from 242 neonatal departments participating in the German national neonatal infection surveillance system NEO-KISS was used to investigate differences in the case fatality risk of microbiology confirmed primary bloodstream infections according to individual pathogens...
2017: PloS One
https://www.readbyqxmd.com/read/28634471/a-chitin-binding-protein-purified-from-moringa-oleifera-seeds-presents-anticandidal-activity-by-increasing-cell-membrane-permeability-and-reactive-oxygen-species-production
#3
João X S Neto, Mirella L Pereira, Jose T A Oliveira, Lady C B Rocha-Bezerra, Tiago D P Lopes, Helen P S Costa, Daniele O B Sousa, Bruno A M Rocha, Thalles B Grangeiro, José E C Freire, Ana Cristina O Monteiro-Moreira, Marina D P Lobo, Raimunda S N Brilhante, Ilka M Vasconcelos
Candida species are opportunistic pathogens that infect immunocompromised and/or immunosuppressed patients, particularly in hospital facilities, that besides representing a significant threat to health increase the risk of mortality. Apart from echinocandins and triazoles, which are well tolerated, most of the antifungal drugs used for candidiasis treatment can cause side effects and lead to the development of resistant strains. A promising alternative to the conventional treatments is the use of plant proteins...
2017: Frontiers in Microbiology
https://www.readbyqxmd.com/read/28632822/-strategies-to-reduce-infections-and-antibiotic-use-and-its-effects-in-a-neonatal-care-unit
#4
Soledad Urzúa, Marcela Ferrés, Patricia García, Amparo Sánchez, Matías Luco
INTRODUCTION: Late onset sepsis (LOS) remains an important cause of morbidity and mortality in neonatal intensive care units (NICU). The empirical use of vancomycin and other broad spectrum antibiotics is very frequent and is associated with the emergence of resistant agents, infection by gram-negative bacilli (GNB), fungal infections and increased morbidity and mortality. OBJECTIVE: To evaluate the impact of 5 intervention protocols designed to reduce infections and promote the rational use of antibiotics (AB) in a single NICU...
April 2017: Revista Chilena de Infectología: órgano Oficial de la Sociedad Chilena de Infectología
https://www.readbyqxmd.com/read/28629089/assembly-of-chitosan-support-matrix-with-gallic-acid-functionalized-nanoparticles
#5
J Lamarra, L Giannuzzi, S Rivero, A Pinotti
The incorporation of gallic acid (GA) in a direct way or into nanoparticles included in chitosan edible films appears as a suitable approach to increase its preservation upon adverse conditions. The addition of nanoparticles to chitosan-based matrices resulted in improvements in their solubility, swelling, and mechanical properties. It is worth noting that by means of the nanoencapsulation, the release process can be modulated in relation to the delivery of GA included directly in the matrix, releasing the agent at a lower rate for a longer time...
October 1, 2017: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/28626746/frequency-of-cutaneous-fungal-infections-and-azole-resistance-of-the-isolates-in-patients-with-diabetes-mellitus
#6
Omid Raiesi, Mansour Siavash, Faezeh Mohammadi, Javaher Chabavizadeh, Behzad Mahaki, Mehrnoush Maherolnaghsh, Parvin Dehghan
BACKGROUND: Diabetic patients are more susceptible to cutaneous fungal infections. The higher blood sugar levels cause increasing the cutaneous fungal infections in these patients. The main objective of this study was to find the frequency of fungal infections among cutaneous lesions of diabetic patients and to investigate azole antifungal agent susceptibility of the isolates. MATERIALS AND METHODS: In this study, type 1diabetes (n = 78) and type 2 diabetes (n = 44) comprised 47 cases (38...
2017: Advanced Biomedical Research
https://www.readbyqxmd.com/read/28625838/comparison-of-time-to-detection-values-between-bact-alert-%C3%A2-virtuo%C3%A2-and-bact-alert-%C3%A2-3d-instruments-for-clinical-blood-cultures-samples
#7
Francesco Congestrì, Maria Federica Pedna, Michela Fantini, Michela Samuelli, Pasqua Schiavone, Arianna Torri, Stefania Bertini, Vittorio Sambri
OBJECTIVES: The early detection of bacteraemia and fungemia is of paramount importance to guide the antimicrobial therapy in septic patients. In this study the "time to detection" (TTD) values for the new blood culture system BacT/ALERT(®) VIRTUO™ (VIRTUO) was evaluated in 1462 positive clinical bottles and compared with the TTD identified for 1601 positive clinical bottles incubated in the BacT/ALERT(®) 3D (BTA 3D). METHODS: The most representative microorganisms isolated from bottles incubated in both blood culture systems were divided into 8 categories (in order of frequency): Coagulase-Negative-Staphylococci (CoNS), Escherichia coli, Enterobacteriaceae (other than E...
June 15, 2017: International Journal of Infectious Diseases: IJID
https://www.readbyqxmd.com/read/28623882/peripheral-venous-catheter-related-bloodstream-infection-is-associated-with-severe-complications-and-potential-death-a-retrospective-observational-study
#8
Akihiro Sato, Itaru Nakamura, Hiroaki Fujita, Ayaka Tsukimori, Takehito Kobayashi, Shinji Fukushima, Takeshi Fujii, Tetsuya Matsumoto
BACKGROUND: The purpose of this study was to identify the clinical characteristics and outcomes of peripheral vascular catheter-related bloodstream infections (PVC-BSIs) and determine the risk of severe complications or death. METHODS: We performed a retrospective observational study from June 2010 to April 2015 at two regional university-affiliated hospitals in Tokyo. We studied the clinical manifestations, underlying diseases, laboratory results, treatment methods, recurrence rates, and complications in 62 hospitalized patients diagnosed with PVC-BSIs by positive blood cultures...
June 17, 2017: BMC Infectious Diseases
https://www.readbyqxmd.com/read/28617561/cervicovaginal-bacteria-and-fungi-in-pregnant-diabetic-and-non-diabetic-women-a-multicenter-observational-cohort-study
#9
A Lukic, A Napoli, I Santino, P Bianchi, F Nobili, G Ciampittiello, M R Nardone, M Santomauro, M Di Properzio, D Caserta
OBJECTIVE: We evaluated the prevalence of cervicovaginal Bacteria, group B Streptococcus (GBS), Gardnerella vaginalis (GV), Candida spp., Chlamydia trachomatis (CT), Mycoplasma hominis (MH) and Ureaplasma urealyticum (UU) in pregnant women with and without diabetes mellitus (DM). PATIENTS AND METHODS: Cervicovaginal swabs were gathered from 473 pregnant patients divided into 127 diabetic and 346 non-diabetic. The results were correlated to gestational age, parity and glycemic control...
May 2017: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/28617137/drugs-currently-under-investigation-for-the-treatment-of-invasive-candidiasis
#10
Matthew W McCarthy, Thomas J Walsh
The widespread implementation of immunosuppressants, immunomodulators, hematopoietic stem cell transplantation and solid organ transplantation in clinical practice has led to an expanding population of patients who are at risk for invasive candidiasis, which is the most common form of fungal disease among hospitalized patients in the developed world. The emergence of drug-resistant Candida spp. has added to the morbidity associated with invasive candidiasis and novel therapeutic strategies are urgently needed...
June 15, 2017: Expert Opinion on Investigational Drugs
https://www.readbyqxmd.com/read/28614081/spontaneous-fungal-peritonitis-a-rare-but-severe-complication-of-liver-cirrhosis
#11
Marta Gravito-Soares, Elisa Gravito-Soares, Sandra Lopes, Graça Ribeiro, Pedro Figueiredo
INTRODUCTION AND AIM: Spontaneous bacterial peritonitis is the most common infectious complication in cirrhosis. Spontaneous fungal peritonitis is rare and remains unknown. In this work, spontaneous fungal peritonitis as well as risk factors and prognosis are characterized. PATIENTS AND METHODS: A retrospective case-control study of 253 consecutive admissions by peritonitis in cirrhotic patients was carried out between 2006 and 2015. Comparison of patients with spontaneous fungal peritonitis (cases) and spontaneous bacterial peritonitis with positive microbiologic ascitic fluid culture (controls) was performed...
June 13, 2017: European Journal of Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/28612029/in-vitro-evaluation-of-antimicrobial-activity-of-alimentary-canal-extracts-from-the-red-palm-weevil-rhynchophorus-ferrugineus-olivier-larvae
#12
Gamal H Sewify, Hanan M Hamada, Hani A Alhadrami
The invasive red palm weevil, Rhynchophorus ferrugineus Olivier (Coleoptera: Curculionidae), is considered one of the world's most devastating insect pests to palm trees. It was observed that larvae of this pest are able to inhibit microbial growth on the rearing media when they start feeding and this observation has led us to study the effect of red palm weevils on various microbial species. The antimicrobial effect of extracts from different parts of the alimentary canal on Gram positive bacteria (Enterococcus faecalis and Staphylococcus aureus), Gram negative bacteria (Escherichia coli and Klebsiella spp...
2017: BioMed Research International
https://www.readbyqxmd.com/read/28604620/reaction-of-bis-2-chlorocarbonyl-phenyl-diselenide-with-phenols-aminophenols-and-other-amines-towards-diphenyl-diselenides-with-antimicrobial-and-antiviral-properties
#13
Mirosław Giurg, Anna Gołąb, Jakub Suchodolski, Rafał Kaleta, Anna Krasowska, Egbert Piasecki, Magdalena Piętka-Ottlik
A reaction of bis[(2-chlorocarbonyl)phenyl] diselenide with various mono and bisnucleophiles such as aminophenols, phenols, and amines have been studied as a convenient general route to a series of new antimicrobial and antiviral diphenyl diselenides. The compounds, particularly bis[2-(hydroxyphenylcarbamoyl)]phenyl diselenides and reference benzisoselenazol-3(2H)-ones, exhibited high antimicrobial activity against Gram-positive bacterial species (Enterococcus spp., Staphylococcus spp.), and some compounds were also active against Gram-negative E...
June 12, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/28603107/anti-fungal-and-anti-mycobacterial-activity-of-plants-of-nuevo-leon-mexico
#14
Blanca Alicia Alanis Garza, Joel López Arroyo, Gloria González González, Elvira Garza González, Elvira Garza González, Noemí Waksman de Torres, Ricardo Salazar Aranda
Severe fungal infections, particularly those caused by Candida spp, have increased in recent decades and are associated with an extremely high rate of morbidity and mortality. Since plants are an important source of potentially bioactive compounds, in this work the antifungal activity of the methanol extracts of 10 plants (Acacia rigidula, Buddleja cordata, Cephalanthus occidentalis, Juglans nigra, Parkinsonia aculeata, Parthenium hysterophorus, Quercus canbyi, Ricinus communis, Salvia coccinea and Teucrium bicolor) were evaluated...
January 2017: Pakistan Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/28601915/volatile-organic-compounds-in-the-breath-of-oral-candidiasis-patients-a-pilot-study
#15
Moritz Hertel, Eyke Schuette, Isabell Kastner, Stefan Hartwig, Andrea Maria Schmidt-Westhausen, Robert Preissner, Sebastian Paris, Saskia Preissner
OBJECTIVES: The aim of the study was to investigate whether specific volatile organic compounds (VOCs) can be detected in oral candidiasis patients using breath analysis in order to develop a point-of-care diagnostic tool. PATIENTS/METHODS: Breath samples of 10 diseased patients and 10 subjects carrying no Candida spp. were analyzed using gas chromatography and mass spectrometry. In infected patients, breath tests were performed before and after antifungal therapy...
June 10, 2017: Clinical Oral Investigations
https://www.readbyqxmd.com/read/28597822/fungi-that-infect-humans
#16
Julia R Köhler, Bernhard Hube, Rosana Puccia, Arturo Casadevall, John R Perfect
Fungi must meet four criteria to infect humans: growth at human body temperatures, circumvention or penetration of surface barriers, lysis and absorption of tissue, and resistance to immune defenses, including elevated body temperatures. Morphogenesis between small round, detachable cells and long, connected cells is the mechanism by which fungi solve problems of locomotion around or through host barriers. Secretion of lytic enzymes, and uptake systems for the released nutrients, are necessary if a fungus is to nutritionally utilize human tissue...
June 2017: Microbiology Spectrum
https://www.readbyqxmd.com/read/28594608/etiology-of-onychomycosis-in-patients-turkey
#17
Fatma Pelin Cengiz, Bengu Cevirgen Cemil, Nazan Emiroglu, Anılgülsel Bahalı, Dilek Biyik Ozkaya, Ozlem Su, Nahide Onsun
BACKGROUND: Onychomycosis is the chronic infection of the nails, and it is caused by dermatophytes, Candida, non- dermatophyte molds, Trichosporon genus. METHODS: A retrospective analysis of 225 cases with onychomycosis, diagnosed in a 27-month period at the Department of Dermatoveneorology, Bezmialem Vakif University in Istanbul, and confirmed with culture. RESULTS: The age of patients ranged from 2 to 87 years (41.59 ± 17.61) and females were more commonly affected (120 cases, 53...
June 8, 2017: Journal of the American Podiatric Medical Association
https://www.readbyqxmd.com/read/28591257/oral-candida-spp-carriage-and-periodontal-diseases-in-hiv-infected-patients-in-ribeir%C3%A3-o-preto-brazil
#18
Alan Grupioni Lourenço, Ana Elisa Rodrigues Alves Ribeiro, Cristiano Nakao, Ana Carolina Fragoso Motta, Luana Grupioni Lourenço Antonio, Alcyone Artioli Machado, Marilena Chinali Komesu
The majority of HIV-infected patients develop Candida spp-associated clinical oral lesions. Studies have shown that asymptomatic oral colonization of Candida spp may lead to oral lesions or become a source of disseminated infections. The aim of this study was to verify the effects of periodontal conditions on Candida spp prevalence and Candida spp carriage in the oral cavity of HIV-infected patients compared to non-infected patients. Twenty-five patients not infected with HIV and 48 HIV-infected patients were classified according to periodontal conditions as being periodontal healthy or with periodontal disease...
June 1, 2017: Revista do Instituto de Medicina Tropical de São Paulo
https://www.readbyqxmd.com/read/28591237/association-between-pathogens-from-tracheal-aspirate-and-oral-biofilm-of-patients-on-mechanical-ventilation
#19
Luana Carneiro Diniz Souza, Vanise Barros Rodrigues da Mota, Alícia Valéria Dos Santos Zaranza de Carvalho, Rita da Graça Carvalhal Frazão Corrêa, Silvana Amado Libério, Fernanda Ferreira Lopes
The aim of this study was to detect possible associations between respiratory pathogens from tracheal aspirate and oral biofilm samples in intubated patients in an intensive care unit (ICU), and to identify the most common respiratory pathogens in oral biofilm, particularly in patients that developed ventilator-associated pneumonia (VAP). Two oral biofilm samples were collected from the tongue of intubated patients (at admission and after 48 hours) and analyzed by culture with the Antibiotic Sensitivity Test...
June 5, 2017: Brazilian Oral Research
https://www.readbyqxmd.com/read/28584446/antimicrobial-activity-of-various-ethanolic-plant-extracts-against-pathogenic-multi-drug-resistant-candida-spp
#20
Shaista Khan, Mohd Imran, Mohammed Imran, Nuzhat Pindari
A total of 50 Candida isolates were isolated and identified from clinical specimens and these were tested for resistance to various antifungal drugs. It was observed multi-drug resistance in all candida isolates by 84%, 62%, 60%, 76%, 46, 30%, and 22% against fluconazole, clotrimazole, Amphotericin B, itraconazole, ketoconazole, miconazole and nystatin tested respectively. The isolates, which were found to be resistant to antifungal drugs were selected and subjected to antifungal testing against six ethanolic plants, extract namely Azadiracta indica, Allium sativum, Cordia dichotoma Ocimum sanctum, Syzygium cumini and Trigonella foenum grecum...
2017: Bioinformation
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