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Candida spp.

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https://www.readbyqxmd.com/read/28928478/biomimetically-engineered-amphotericin-b-nano-aggregates-circumvent-toxicity-constraints-and-treat-systemic-fungal-infection-in-experimental-animals
#1
Qamar Zia, Owais Mohammad, Mohd Ahmar Rauf, Wasi Khan, Swaleha Zubair
Biomimetic synthesis of nanoparticles offers a convenient and bio friendly approach to fabricate complex structures with sub-nanometer precision from simple precursor components. In the present study, we have synthesized nanoparticles of Amphotericin B (AmB), a potent antifungal agent, using Aloe vera leaf extract. The synthesis of AmB nano-assemblies (AmB-NAs) was established employing spectro-photometric and electron microscopic studies, while their crystalline nature was established by X-ray diffraction...
September 19, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28926981/antibiofilm-activity-and-mechanism-of-action-of-the-disinfectant-chloramine-t-on-candida-spp-and-its-toxicity-against-human-cells
#2
Gabriela Lacet Silva Ferreira, Pedro Luiz Rosalen, Larissa Rangel Peixoto, Ana Luiza Alves de Lima Pérez, Fabíola Galbiatti de Carvalho Carlo, Lúcio Roberto Cançado Castellano, Jefferson Muniz de Lima, Irlan Almeida Freires, Edeltrudes de Oliveira Lima, Ricardo Dias de Castro
We evaluated the antifungal and anti-biofilm activity, mechanism of action and cytotoxicity of chloramine T trihydrate (CAT) against Candida spp. The Minimum Inhibitory and Fungicidal Concentrations (MIC/MFC) of CAT were determined. Changes in CAT-treated C. albicans growth kinetics and micromorphology were evaluated, as well as the mechanism of action, and its effects on biofilm. Cytotoxicity was assessed by the hemolysis method. The data were analyzed by inferential statistics (p ≤ 0.05). CAT showed antifungal activity against all strains, with MIC values ranging between 1...
September 17, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/28923300/influence-of-co-infection-complicated-with-human-papillomavirus-on-cervical-intraepithelial-neoplasia-development-in-patients-with-atypical-squamous-cells-of-undetermined-significance
#3
Hisami Kiseki, Yutaka Tsukahara, Natsumi Tajima, Ayako Tanaka, Aya Horimoto, Naohiko Hashimura
AIM: Human papillomaviruses (HPV) infection is a primary cause of the development of cervical precancerous lesions and cervical cancer. However, the influence of other infections on intraepithelial neoplasia (CIN) development has not been fully elucidated. We evaluated the association between co-infection and CIN development in subjects with atypical squamous cells of undetermined significance (ASCUS). METHOD: Data for ASCUS subjects who had undergone testing for high risk HPV (HR-HPV) and pathological diagnosis were analyzed...
September 8, 2017: Journal of Infection and Chemotherapy: Official Journal of the Japan Society of Chemotherapy
https://www.readbyqxmd.com/read/28919715/in-vitro-inhibitory-activities-of-magnolol-against-candida-spp
#4
Peiru Zhou, Jingya Fu, Hong Hua, Xiaosong Liu
Candida spp. cause various infections involving the skin, mucosa, deep tissues, and even life-threatening candidemia. They are regarded as an important pathogen of nosocomial bloodstream infection, with a high mortality rate. As a result of prolonged exposure to azoles, the therapeutic failure associated with azoles resistance has become a serious challenge in clinical situations. Therefore, novel, alternative antifungals are required urgently. In the present study, the CLSI M-27A broth microdilution method and the 2,3-Bis-(2-methoxy-4-nitro-5-sulfophenyl)-2H-tetrazolium-5-carboxanilide (XTT) reduction assay were used to evaluate the antifungal effects of magnolol against various standard Candida strains in planktonic mode and biofilm formation, respectively...
2017: Drug Design, Development and Therapy
https://www.readbyqxmd.com/read/28913648/combined-effect-of-the-saccharomyces-cerevisiae-lag-phase-and-the-non-saccharomyces-consortium-to-enhance-wine-fruitiness-and-complexity
#5
Warren Albertin, Adrien Zimmer, Cécile Miot-Sertier, Margaux Bernard, Joana Coulon, Virginie Moine, Benoit Colonna-Ceccaldi, Marina Bely, Philippe Marullo, Isabelle Masneuf-Pomarede
Non-Saccharomyces (NS) species that are either naturally present in grape must or added in mixed fermentation with S. cerevisiae may impact the wine's chemical composition and sensory properties. NS yeasts are prevailing during prefermentation and early stages of alcoholic fermentation. However, obtaining the correct balance between S. cerevisiae and NS species is still a critical issue: if S. cerevisiae outcompetes the non-Saccharomyces, it may minimize their impact, while conversely if NS take over S. cerevisiae, it may result in stuck or sluggish fermentations...
September 14, 2017: Applied Microbiology and Biotechnology
https://www.readbyqxmd.com/read/28913339/ulcerative-gastritis-and-esophagitis-in-two-children-with-sarcina-ventriculi-infection
#6
Tim G J de Meij, Michiel P van Wijk, Aart Mookhoek, Andries E Budding
Sarcina ventriculi is a Gram-positive, obligate anaerobic coccus, with a characteristic morphology. Only 22 cases of human infections by this microorganism, including 7 in children, have been reported in literature so far. Affected subjects usually present with abdominal pain, nausea, vomiting, and delayed gastric emptying. However, life-threatening complications, like emphysematous gastritis and gastric perforation have also been described. Gastroparesis and gastric outlet obstruction have been considered as a potential etiologic factor...
2017: Frontiers in Medicine
https://www.readbyqxmd.com/read/28904369/antimutagenic-and-antioxidant-activity-of-the-essential-oils-of-citrus-sinensis-and-citrus-latifolia
#7
J D Toscano-Garibay, M Arriaga-Alba, J Sánchez-Navarrete, M Mendoza-García, J J Flores-Estrada, M A Moreno-Eutimio, J J Espinosa-Aguirre, M González-Ávila, N J Ruiz-Pérez
The essential oils of Citrus sinensis and Citrus latifolia showed antimycotic activity against Candida spp. isolated from the oral cavity; they are neither mutagenic on the Ames test nor cytotoxic. Their main components are R-(+)-limonene, β-thujene, α-myrcene and γ-terpinene. The aim of this work was to evaluate their antimutagenic and antioxidant capacities. Antimutagenic properties were evaluated against MNNG and ENNG on S. typhimurium TA100; against 2AA on strain TA98 and in front of 4NQO and NOR on strain TA102...
September 13, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28888760/an-in-vitro-investigation-of-indigenous-south-african-medicinal-plants-used-to-treat-oral-infections
#8
S Akhalwaya, S van Vuuren, M Patel
ETHNOPHARMACOLOGICAL RELEVANCE: Over a 120 South African medicinal plants are used for the treatment of oral diseases. Despite the vast collection of antimicrobial studies being done on South African plants, there is still limited research on pathogens associated with oral infections. In consultation with the available ethnobotanical literature, this study investigates the antimicrobial efficacy of some South African medicinal plants against oral pathogens. AIM OF THE STUDY: To provide a detailed account of the antimicrobial properties of selected South African medicinal plants used traditionally to treat oral infections...
September 7, 2017: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/28887004/-mycological-profile-of-hand-onychomycosis-amongs-garba-sellers-in-abidjan-c%C3%A3-te-d-ivoire
#9
P C M Kiki-Barro, A Konaté, F K Kassi, E K Angora, H Bosson-Vanga, A V Bedia-Tanoh, V Djohan, W Yavo, E I H Menan
OBJECTIVE: The aim of this study is to determine the prevalence and the fungi involved in onychomycosis located on fingers in Abidjan. MATERIAL AND METHODS: This study includes the sellers of cooked cassava semolina served with fried tuna fish called "garba". Fines squames specimen was processed with 30% KOH for a direct microscope examination. Serous collection were done in physiological serum. Part of the original sample was cultured on Sabouraud medium with antibiotics (chloramphénicol, actidione)...
September 5, 2017: Journal de Mycologie Médicale
https://www.readbyqxmd.com/read/28876392/antifungal-and-antioxidant-activity-of-fatty-acid-methyl-esters-from-vegetable-oils
#10
Maria E A Pinto, Sthéfane G Araújo, Marcela I Morais, Nívea P Sá, Caroline M Lima, Carlos A Rosa, Ezequias P Siqueira, Susana Johann, Luciana A R S Lima
Fatty acid methyl esters (FAMEs) were obtained from vegetable oils of soybean, corn and sunflower. The current study was focused on evaluating the antifungal activity of FAMEs mainly against Paracoccidioides spp., as well as testing the interaction of these compounds with commercial antifungal drugs and also their antioxidant potential. FAMEs presented small IC50 values (1.86-9.42 μg/mL). All three FAMEs tested showed antifungal activity against isolates of Paracoccidioides spp. with MIC values ranging from 15...
August 31, 2017: Anais da Academia Brasileira de Ciências
https://www.readbyqxmd.com/read/28872720/laboratory-based-investigation-of-denture-sonication-method-in-patients-with-candida-associated-denture-stomatitis
#11
Mirjana Perić, Milena Radunović, Marina Pekmezović, Jelena Marinković, Rade Živković, Valentina Arsić Arsenijević
PURPOSE: Denture stomatitis (DS) is a disease characterized by inflammation and erythema of the oral mucosa areas covered by the denture. Multifactorial etiological factors contribute to DS, but it seems that Candida plays the key role. The aim of the study was to evaluate the denture sonication method to: (i) increase the possibility of diagnosing patients with Candida-associated DS; (ii) detect and identify the mixed Candida spp., and (iii) determine the Candida colony forming units (CFU) and its possible relationship with DS severity, based on Newton's classification...
September 5, 2017: Journal of Prosthodontics: Official Journal of the American College of Prosthodontists
https://www.readbyqxmd.com/read/28858271/-the-relevance-of-candida-spp-in-chronic-periodontal-disease
#12
I N Razina, M G Chesnokova, V B Nedoseko
The aim of the study was to assess the correlation of Candida spp. incidence in periodontal tissues with various clinical manifestations of chronic periodontal disease (CPD). Ninety patients with CPD were included in the study in which Candida spp. was evaluated in periodontal pockets content and gingival biopsy material. In severe CPD more Candida spp. were seen in gingival biopsy than in periodontal pockets (p=0.0006). Candida spp. incidence and quantity correlated directly with the disease grade showing incidence increase from 40 to 73...
2017: Stomatologii︠a︡
https://www.readbyqxmd.com/read/28846777/efficacy-of-a-fixed-combination-of-tetracycline-chloramphenicol-and-colistimethate-sodium-for-treatment-of-candida-albicans-keratitis
#13
Anna R Blanco, Antonia Nostro, Valeria D'Angelo, Manuela D'Arrigo, Maria G Mazzone, Andreana Marino
Purpose: To evaluate the antifungal activity of a fixed antibiotic combination (AC) containing tetracycline (TET), chloramphenicol (CAF), and colistimethate sodium (CS). Methods: In vitro: Candida ATCC and clinical strains were used. The minimum inhibitory concentrations (MICs) of AC and of each antibiotic were determined. Fluconazole (FLC) was tested for comparison. Time-killing curves of selected strains were performed. Ex vivo keratitis: corneas were injected intrastromally with the selected strains...
August 1, 2017: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/28843417/evaluation-of-primitive-ground-water-supplies-as-a-risk-factor-for-the-development-of-major-waterborne-zoonosis-in-egyptian-children-living-in-rural-areas
#14
Hassan A Elfadaly, Nawal A Hassanain, Mohey A Hassanain, Ashraf M Barakat, Raafat M Shaapan
BACKGROUND: Endemic waterborne zoonosis frequently occurs in both developed and less developed countries. Thus, bio-surveillance of waterborne zoonosis is a "necessity" for the implementation of effective preventive public health measures in Egyptian rural areas. The primitive individual water supplies created by the rural agriculture population, primarily from ground water, usually maximize the customers' exposure to impurity pathogens via diffused humans and animal excreta or wastages...
August 23, 2017: Journal of Infection and Public Health
https://www.readbyqxmd.com/read/28831255/stratum-corneum-lipid-liposome-encapsulated-panomycocin-preparation-characterization-and-the-determination-of-antimycotic-efficacy-against-candida-spp-isolated-from-patients-with-vulvovaginitis-in-an-in-vitro-human-vaginal-epithelium-tissue-model
#15
Fatih İzgü, Günce Bayram, Kübra Tosun, Demet İzgü
In this study, a liposomal lyophilized powder formulation of panomycocin was developed for therapeutic purposes against vulvovaginal candidiasis which affects 80% of women worldwide. Panomycocin is a potent antimycotic protein secreted by the yeast Wickerhamomyces anomalus NCYC 434. This study involved the preparation of panomycocin-loaded stratum corneum lipid liposomes (SCLLs), characterization of the SCLLs, and determination of antimycotic efficacy of the formulation against Candida albicans and Candida glabrata clinical vaginal isolates in a human vaginal epithelium tissue model...
2017: International Journal of Nanomedicine
https://www.readbyqxmd.com/read/28827996/apigenin-7-o-glucoside-versus-apigenin-insight-into-the-modes-of-anticandidal-and-cytotoxic-actions
#16
Marija Smiljkovic, Danijela Stanisavljevic, Dejan Stojkovic, Isidora Petrovic, Jelena Marjanovic Vicentic, Jelena Popovic, Simona Golic Grdadolnik, Dejan Markovic, Snežana Sankovic-Babice, Jasmina Glamoclija, Milena Stevanovic, Marina Sokovic
Bioactive potential of apigenin derivative apigenin-7-O-glucoside related to its antifungal activity on Candida spp. and cytotoxic effect on colon cancer cells was studied and compared with bioactive potential of apigenin. Antifungal activity was tested on 14 different isolates of Candida spp. using membrane permeability assay, measuring inhibition of reactive oxidative species and inhibition of CYP51 C. albicans enzyme. Cytotoxic potential of apigenin-7-O-glucoside was tested on colon cancer HCT116 cells by measuring cell viability, apoptosis rate and apoptosis- and colon cancer-related gene expression...
2017: EXCLI journal
https://www.readbyqxmd.com/read/28826987/in-vitro-potency-and-fungicidal-activity-of-cd101-a-novel-echinocandin-against-recent-clinical-isolates-of-candida-spp
#17
Danielle Hall, Robert Bonifas, Lauretta Stapert, Mary Thwaites, Dean L Shinabarger, Chris M Pillar
Candida infections vary in severity and manifestation. Common infections include invasive bloodstream infections among hospitalized/immunocompromised patients and vulvovaginal candidiasis among women. Echinocandins and azoles are commonly utilized to treat Candida infections, although echinocandin use has been restricted to indications amenable to once-daily IV administration. CD101, a novel echinocandin with a long plasma half-life and enhanced stability, is in development for once-weekly IV administration for the treatment of candidemia and invasive candidiasis...
July 21, 2017: Diagnostic Microbiology and Infectious Disease
https://www.readbyqxmd.com/read/28820494/immune-response-patterns-and-next-generation-sequencing-diagnostics-for-the-detection-of-mycoses-in-patients-with-septic-shock-results-of-a-combined-clinical-and-experimental-investigation
#18
Sebastian O Decker, Annette Sigl, Christian Grumaz, Philip Stevens, Yevhen Vainshtein, Stefan Zimmermann, Markus A Weigand, Stefan Hofer, Kai Sohn, Thorsten Brenner
Fungi are of increasing importance in sepsis. However, culture-based diagnostic procedures are associated with relevant weaknesses. Therefore, culture- and next-generation sequencing (NGS)-based fungal findings as well as corresponding plasma levels of β-d-glucan, interferon gamma (INF-γ), tumor necrosis factor alpha (TNF-α), interleukin (IL)-2, -4, -6, -10, -17A, and mid-regional proadrenomedullin (MR-proADM) were evaluated in 50 septic patients at six consecutive time points within 28 days after sepsis onset...
August 18, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28818628/a-prospective-multicentre-study-of-the-epidemiology-and-outcomes-of-bloodstream-infection-in-cirrhotic-patients
#19
Michele Bartoletti, Maddalena Giannella, Russell Lewis, Paolo Caraceni, Sara Tedeschi, Mical Paul, Christoph Schramm, Tony Bruns, Manuela Merli, Nazaret Cobos-Trigueros, Elena Seminari, Pilar Retamar, Patricia Muñoz, Mario Tumbarello, Patrizia Burra, Maria Torrani Cerenzia, Bruno Barsic, Ester Calbo, Alberto Enrico Maraolo, Nicola Petrosillo, Maria Angeles Galan-Ladero, Giampiero D'Offizi, Noa Bar Sinai, Jesus Rodríguez-Baño, Gabriella Verucchi, Mauro Bernardi, Pierluigi Viale
OBJECTIVE: The aim of this study was to describe the current epidemiology of BSI in patients with cirrhosis, analyse predictors of 30-day mortality, and risk factors for antibiotic resistance. METHODS: Cirrhotic patients developing a BSI episode were prospectively included at 19 centres in five countries from September 2014 to December 2015. The discrimination of mortality risk scores for 30-day mortality were compared by area under the receiver operator-risk and Cox-regression models...
August 14, 2017: Clinical Microbiology and Infection
https://www.readbyqxmd.com/read/28818396/identification-and-susceptibility-testing-of-candida-spp-directly-from-yeast-positive-blood-cultures-with-vitek-2
#20
María Fernanda González-Lara, Pedro Torres-González, Andrea Rangel-Cordero, José Sifuentes-Osornio, Alfredo Ponce-de-León, Areli Martínez-Gamboa
Culture-based identification and antifungal susceptibility take 48-72hours after positivity. We analyzed the performance of Vitek2 directly from 40 yeast-positive blood-cultures; agreement of 100% was observed for the tested antifungals; identification showed the same species in 31/40. The method reduces time (13 to 18h) for preliminary results.
July 14, 2017: Diagnostic Microbiology and Infectious Disease
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