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Candida spp.

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https://www.readbyqxmd.com/read/29144965/role-of-serum-1-3%C3%AE-d-glucan-assay-in-early-diagnosis-of-invasive-fungal-infections-in-a-neonatal-intensive-care-unit
#1
Abd Elazeez Shabaan, Lobna Mahmoud Elbaz, Wafaa M El-Emshaty, Basma Shouman
OBJECTIVES: To study the microbiological pattern of late onset neonatal sepsis cultures and to assess the diagnostic performance of serum (1,3)-β-d-glucan level for early diagnosis of invasive fungemia in high-risk infants admitted to a neonatal intensive care unit. METHODS: A prospective multicenter clinical trial conducted on infants at high risk for invasive fungal infections, with suspected late onset sepsis, admitted to a neonatal intensive care unit at Mansoura University Children's Hospital and Mansoura General Hospital between March 2014 and February 2016...
November 13, 2017: Jornal de Pediatria
https://www.readbyqxmd.com/read/29142743/anti-candida-activity-of-antimicrobial-impregnated-central-venous-catheters
#2
L Cobrado, A Silva-Dias, M M Azevedo, A Rodrigues
Background: Whenever the rate of central line-associated bloodstream infections (CLABSIs) remains high even after the implementation of preventive strategies, the use of chlorhexidine/silver sulfadiazine (CSS) or minocycline/rifampin (MR)-impregnated central venous catheters (CVCs) is currently recommended. Nevertheless, the efficacy of such CVCs against Candida albicans and other emerging non-albicans spp. has been insufficiently studied. This study aims to compare the activity of CSS and MR-impregnated CVCs against the yeasts most frequently isolated from CLABSIs...
2017: Antimicrobial Resistance and Infection Control
https://www.readbyqxmd.com/read/29139623/extracellular-proteinases-of-candida-species-pathogenic-yeasts
#3
Maria Rapala-Kozik, Oliwia Bochenska, Dorota Zajac, Justyna Karkowska-Kuleta, Mariusz Gogol, Marcin Zawrotniak, Andrzej Kozik
The increased incidence of severe disseminated infections caused by opportunistic yeast-like fungi Candida spp. highlights the urgent need for research into the major virulence factors of these pathogens - extracellular aspartic proteinases of the candidapepsin and yapsin families. Classically, these enzymes were considered to be generally destructive factors that damage host tissues and provide nutrients for pathogen propagation. However, in recent decades, novel and more specific functions have been suggested for extracellular candidal proteinases...
November 15, 2017: Molecular Oral Microbiology
https://www.readbyqxmd.com/read/29132795/-interdigital-tinea-pedis-resulting-from-fusarium-spp-in-dakar-senegal
#4
K Diongue, M A Diallo, M Ndiaye, M C Seck, A S Badiane, D Ndiaye
INTRODUCTION: Fungal interdigital tinea pedis (ITP) is a common pathology mainly due to dermatophytes and yeasts. Fusarium sp. is rarely incriminated in the genesis of intertrigo. In Dakar, a recent study conducted in 2016 on fungal ITP showed that Fusarium were more involved in the etiology of ITP than dermatophytes, coming just after yeasts dominated by Candida. Following this, we wanted to draw attention to the increasing incidence of ITP resulting from Fusarium spp., in Dakar, Senegal, and to analyze the epidemiological and mycological particularities of these ITP due to Fusarium spp...
November 10, 2017: Journal de Mycologie Médicale
https://www.readbyqxmd.com/read/29130974/atypical-squamous-cells-in-liquid-based-cervical-cytology-microbiology-inflammatory-infiltrate-and-human-papillomavirus-dna-testing
#5
Geilson Gomes de Oliveira, Renata Mirian Nunes Eleutério, Ana Katherine Silveira Gonçalves, Paulo César Giraldo, José Eleutério
OBJECTIVE: The aim of this study was to assess the correlation between atypical squamous cells (ASC) and inflammatory infiltrate and vaginal microbiota using cervical liquid-based cytological (SurePath®) and high-risk human papillomavirus (HR-HPV) tests. STUDY DESIGN: A cross-sectional study was conducted using a 6-year database from a laboratory in Fortaleza (Brazil). Files from 1,346 ASC cases were divided into subgroups and results concerning inflammation and vaginal microorganisms diagnosed by cytology were compared with HR-HPV test results...
November 8, 2017: Acta Cytologica
https://www.readbyqxmd.com/read/29129498/a-novel-double-layer-mucoadhesive-tablet-containing-probiotic-strain-for-vaginal-administration-design-development-and-technological-evaluation
#6
María Teresa Sánchez, María Adolfina Ruiz, Herminia Castán, María Encarnación Morales
Vulvovaginal candidosis caused by Candida spp. is the most prevalent vaginal infection in Europe and the second one in EE.UU, so it has become a major female concern. Probiotics bacteria have been proposed as an alternative treatment with the aim of avoiding the adverse effects associated with conventional therapies including antibiotics and other aggressive drugs for the vaginal mucosa and microbiota. The purpose of this work was to design and develop a novel vaginal tablet that contained Lactobacillus spp...
November 9, 2017: European Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/29127615/fungal-and-parasitic-cns-infections
#7
Pratibha Singhi, Arushi Gahlot Saini
Central nervous system fungal infections can be broadly divided into those that infect a healthy host such as Cryptococcus, Coccidioides, Histoplasma, Blastomyces, Sporothrix spp., and those that cause opportunistic infections in an immunocompromised host such as Candida, Aspergillus, Zygomycetes, Trichosporon spp. The clinical manifestations of central nervous system fungal infections commonly seen in children in clinical practice include a chronic meningitis or meningoencephalitis syndrome, brain abscess, rhino-cerebral syndrome and rarely, a fungal ventriculitis...
November 11, 2017: Indian Journal of Pediatrics
https://www.readbyqxmd.com/read/29125139/salivary-proteins-and-microbiota-as-biomarkers-for-early-childhood-caries-risk-assessment
#8
REVIEW
Abdullah S Hemadi, Ruijie Huang, Yuan Zhou, Jing Zou
Early childhood caries (ECC) is a term used to describe dental caries in children aged 6 years or younger. Oral streptococci, such as Streptococcus mutans and Streptococcus sorbrinus, are considered to be the main etiological agents of tooth decay in children. Other bacteria, such as Prevotella spp. and Lactobacillus spp., and fungus, that is, Candida albicans, are related to the development and progression of ECC. Biomolecules in saliva, mainly proteins, affect the survival of oral microorganisms by multiple innate defensive mechanisms, thus modulating the oral microflora...
November 10, 2017: International Journal of Oral Science
https://www.readbyqxmd.com/read/29111434/empiric-treatment-of-lower-urinary-tract-infections-in-the-face-of-spreading-multi-drug-resistance-in-vitro-study-of-nitroxoline-effectiveness
#9
A Sobke, O Makarewicz, M Baier, C Bär, W Pfister, S G Gatermann, M W Pletz, C Forstner
The spread of antimicrobial resistance challenges the empiric treatment in urinary tract infections (UTI). Among others, nitrofurantoin is recommended for first line treatment, but acceptance among clinicians is limited due to chronic nitrofurantoin-induced lung toxicity and insufficient coverage of Enterobacteriaceae other than Escherichia coli. Nitroxoline seems to be an alternative to nitrofurantoin due to its favourable safety profile but data on its current in vitro susceptibility are sparse. In this study susceptibility to nitroxoline was tested against 3,012 urinary clinical isolates (including multidrug-resistant bacteria and Candida spp...
October 27, 2017: International Journal of Antimicrobial Agents
https://www.readbyqxmd.com/read/29111389/antifungal-photosensitive-activity-of-porophyllum-obscurum-spreng-dc-correlation-of-the-chemical-composition-of-the-hexane-extract-with-the-bioactivity
#10
Agustina Postigo, Matías Funes, Elisa Petenatti, Hebe Bottai, Adriana Pacciaroni, Maximiliano Sortino
In this paper, we report Porophyllum obscurum as a source of new photosensitizers with potential use in Photodynamic Therapy as an alternative for oropharyngeal candidiasis treatment. The antifungal photosensitive activity of different extracts from P. obscurum was evaluated by using microdilution and bioautographic assays. The Minimum Fungicidal Concentration for hexanic extract under UV-A irradiation was 0.98μg/mL, but it was inactive in experiments without irradiation. The bioassay-guided fractionation of this extract led to the isolation of four thiophenes responsible for the photosensitive activity: 2,2':5'2″terthiophene, 5-(3-buten-1-ynyl)-2,2'-bithiophene, 5-(4-acetoxy-1-butenyl)-2,2'- bithiophene and 5-(4-hydroxy-1-butenyl)-2,2'- bithiophene, with Minimum Fungicidal Concentrations ranging 0...
October 27, 2017: Photodiagnosis and Photodynamic Therapy
https://www.readbyqxmd.com/read/29104381/comparison-of-antimicrobial-efficacy-of-green-tea-garlic-with-lime-and-sodium-fluoride-mouth-rinses-against-streptococcus-mutans-lactobacilli-species-and-candida-albicans-in-children-a-randomized-double-blind-controlled-clinical-trial
#11
Ann Thomas, Sneha Thakur, Rishika Habib
Introduction: With greater awareness worldwide, the use of herbs and herbal products has increased to a large extent. Objective: To evaluate and compare the antimicrobial efficacy of green tea, garlic with lime, and 0.05% sodium fluoride (NaF) mouth rinses against Streptococcus mutans, Lactobacilli species, and Candida albicans. Materials and methods: A total of 45 children aged 4 to 6 years with severe early childhood caries (S-ECC; based on decayed extracted filled [defs] score) were selected...
July 2017: International Journal of Clinical Pediatric Dentistry
https://www.readbyqxmd.com/read/29104260/antimicrobial-and-anti-proliferative-effects-of-skin-mucus-derived-from-dasyatis-pastinaca-linnaeus-1758
#12
Virginia Fuochi, Giovanni Li Volti, Giuseppina Camiolo, Francesco Tiralongo, Cesarina Giallongo, Alfio Distefano, Giulio Petronio Petronio, Ignazio Barbagallo, Maria Viola, Pio Maria Furneri, Michelino Di Rosa, Roberto Avola, Daniele Tibullo
Resistance to chemotherapy occurs in various diseases (i.e., cancer and infection), and for this reason, both are very difficult to treat. Therefore, novel antimicrobial and chemotherapic drugs are needed for effective antibiotic therapy. The aim of the present study was to assess the antimicrobial and anti-proliferative effects of skin mucus derived from Dasyatis pastinaca (Linnaeus, 1758). Our results showed that skin mucus exhibited a significant and specific antibacterial activity against Gram-negative bacteria but not against Gram-positive bacteria...
November 1, 2017: Marine Drugs
https://www.readbyqxmd.com/read/29102310/-vertebral-osteomyelitis-due-to-candida-tropicalis-secondary-to-candidemia-a-case-report
#13
S Zayet, I Chaabane, B Kilani, M Bouaziz, F Ladeb, H B Tiouiri
Candida spp. vertebral osteomyelitis is rare. Clinical presentation is unspecific. Diagnosis requires mycological culture of a biopsy specimen. Therapeutic management is based on prolonged course of azole or liposomal amphotericin B. We report the case of Candida tropicalis vertebral osteomyelitis with epidural involvement in a 27 years-old male patient, followed for S-β-thalassemia and with a history of candidemia. The fungus was isolated from a needle biopsy of the vertebral disk. The outcome was favorable under antifungal treatment by amphotericin B and voriconazole...
October 25, 2017: Journal de Mycologie Médicale
https://www.readbyqxmd.com/read/29101578/biosurfactant-production-by-yeasts-isolated-from-hydrocarbon-polluted-environments
#14
Kamalpreet Kaur, Seema Sangwan, Harpreet Kaur
Thirty-two yeast isolates were retrieved from four soil samples collected from hydrocarbon-polluted locations of Hisar, Haryana, using enrichment culture technique with 1% (v/v) diesel as carbon source. Total nine isolates showing blood agar haemolysis were screened further for biosurfactant production. Yeast isolate, YK32, gave highest 8.4-cm oil displacement which was found to be significantly higher as compared to positive control, 0.2% (w/v) SDS (6.6 cm), followed by 6.2 and 6.0 cm by isolates YK20 and YK21, respectively...
November 3, 2017: Environmental Monitoring and Assessment
https://www.readbyqxmd.com/read/29096992/epidemiology-and-risk-factors-for-mortality-in-bloodstream-infection-by-cp-kp-esbl-e-candida-and-cdi-a-single-center-retrospective-study
#15
Silvia Corcione, Roberto Angilletta, Stefania Raviolo, Claudia Filippini, Lucina Fossati, Giovanni Di Perri, Rossana Cavallo, Francesco Giuseppe De Rosa
BACKGROUND: The incidence of C. difficile infection (CDI) and of bloodstream infection (BSI) caused by Candida spp., ESBL-E-producing Enterobacteriaceae (ESBL-E) and carbapenemase-producing K. pneumoniae (CP-Kp) is associated with high mortality. METHODS: We conducted a single centre retrospective study on patients admitted to Molinette Hospital, Turin, Italy, from January 2013 to April 2015 with CDI or BSI caused by Candida, ESBL-E or CP-Kp. For each patient demographic, clinical and microbiological data were collected...
October 30, 2017: European Journal of Internal Medicine
https://www.readbyqxmd.com/read/29095200/emerging-multidrug-resistant-candida-species
#16
Arnaldo L Colombo, João N de Almeida Júnior, Jesus Guinea
PURPOSE OF REVIEW: To describe the epidemiology, strategies for early detection, and clinical management of infections caused by the most commonly found multidrug-resistant (MDR) Candida spp. RECENT FINDINGS: Increasing numbers of reports describing invasive infections by MDR Candida auris and Candida glabrata has been reported in medical centers worldwide. SUMMARY: We checked all papers published along the last 10 years describing epidemiological, diagnostic, and clinical aspects of infections by MDR Candida spp...
December 2017: Current Opinion in Infectious Diseases
https://www.readbyqxmd.com/read/29081917/inactivation-of-genes-tec1-and-efg1-in-candida-albicans-influences-extracellular-matrix-composition-and-biofilm-morphology
#17
Beatriz Helena Dias Panariello, Marlise I Klein, Ana Claudia Pavarina, Simone Duarte
Background: Infections caused by Candida spp. have been associated with formation of a biofilm, i.e. a complex microstructure of cells adhering to a surface and embedded within an extracellular matrix (ECM). Methods: The ECMs of a wild-type (WT, SN425) and two Candida albicans mutant strains, Δ/Δ tec1 (CJN2330) and Δ/Δ efg1 (CJN2302), were evaluated. Colony-forming units (cfu), total biomass (mg), water-soluble polysaccharides (WSPs), alkali-soluble polysaccharides (ASPs), proteins (insoluble part of biofilms and matrix proteins), and extracellular DNA (eDNA) were quantified...
2017: Journal of Oral Microbiology
https://www.readbyqxmd.com/read/29077791/prosthetic-valve-candida-spp-endocarditis-new-insights-into-long-term-prognosis-the-escape-study
#18
Claire Rivoisy, Antonio Vena, Laura Schaeffer, Caroline Charlier, Arnaud Fontanet, François Delahaye, Emilio Bouza, Olivier Lortholary, Patricia Munoz, Agnès Lefort
Background: Prosthetic valve endocarditis caused by Candida spp. (PVE-C) is rare and devastating, with international guidelines based on expert recommendations consisting in the combination of surgery and subsequent azole treatment. Methods: PVE-C collected in Spain and France between 2001 and 2015 were retrospectively analyzed with a focus on management and outcome. Results: Forty-six cases were followed up for a median of 9 months. Twenty-two (48%) patients had a past history of endocarditis; 30 (65%) cases were nosocomial or healthcare-related, 9 (20%) patients were intravenous drug users...
October 25, 2017: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
https://www.readbyqxmd.com/read/29074435/the-natural-compound-magnolol-affects-growth-biofilm-formation-and-ultrastructure-of-oral-candida-isolates
#19
Jawad Behbehani, Sheikh Shreaz, Mohammad Irshad, Maribassapa Karched
The incidence of oral candidosis has increased in recent years due to the escalation in HIV-infection, cancer treatments, organ transplantation, and diabetes. In addition, corticosteroid use, dentures, and broad-spectrum antibiotic use have also contributed to the problem. Treatment of oral candidosis has continued to be problematic because of the potential toxicity of antifungals in clinical use, and, above all, development of drug resistance among patients. In this study, the antifungal effect of magnolol was investigated against 64 strains of Candida spp...
October 23, 2017: Microbial Pathogenesis
https://www.readbyqxmd.com/read/29074432/healthcare-workers-hands-as-a-vehicle-for-the-transmission-of-virulent-strains-of-candida-spp-a-virulence-factor-approach
#20
Karina Mayumi Sakita, Daniella Renata Faria, Eliane Martins da Silva, Flávia Kelly Tobaldini-Valério, Erika Seki Kioshima, Terezinha Inez Estivalet Svidzinski, Patricia de Souza Bonfim-Mendonça
BACKGROUND: Although the majority of Candida infections are thought to come from endogenous sources, the healthcare workers' (HCWs) hands are being increasingly reported as vehicles for the transmission of pathogens. The aim of the present study was to evaluate the susceptibility of yeast isolated from the HCWs' hands and ICU (Intensive Care Unit) surfaces to antifungal agents and to determine the virulence potential and the genetic similarity between the same. METHODS: The susceptibility of yeasts from the HCWs' hands (n = 57) and ICU surfaces (n = 98) to conventional antifungals (fluconazole, voriconazole, amphotericin B and micafungin) was evaluated using the broth microdilution assay accordance with CLSI M27-A3...
October 23, 2017: Microbial Pathogenesis
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