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https://www.readbyqxmd.com/read/29780757/huge-candida-albicans-normal-native-tricuspid-valve-endocarditis
#1
Massimiliano Guerriero, Francesco Colasurdo, Anna Maria Pollio
Fungal endocarditis has become an important infection associated with medical progress and the modern lifestyle. In particular, Candida spp. is a rare but important cause of infective endocarditis. We report the case of a 28-year-old woman-quadriplegic and bedridden from birth-who died after repeated episodes of pneumonia treated with different regimens of intravenous antibiotics. A medico legal autopsy was performed, which diagnosed severe Candida native valve infective endocarditis (CIE). This case report illustrates the prolonged use of antibiotic treatment as a possible risk factor for the development of CIE...
April 2018: Autopsy & Case Reports
https://www.readbyqxmd.com/read/29766800/antifungal-activity-gas-chromatographic-mass-spectrometric-analysis-and-in-silico-study-of-punica-granatum-peel-extracts-against-fluconazole-resistant-strains-of-candida-species
#2
Sony Paul, M Kalyani, I Kannan
AIMS: Candida species is the common cause of opportunistic fungal infections all over the world with increased mortality and morbidity especially in immunosuppressed patients. Fluconazole is the first line therapy for candidiasis. The antifungal resistance pattern in high-risk patients is a major concern. The present study was aimed to assess the anticandidal activity of Punica granatum peel against fluconazole resistant Candida species isolated from HIV patients. MATERIALS & METHODS: Ethanol, chloroform, petroleum ether and aqueous extracts of the peel of P...
May 14, 2018: Current Pharmaceutical Biotechnology
https://www.readbyqxmd.com/read/29762861/pharmacokinetic-pharmacodynamic-analysis-of-isavuconazole-against-aspergillus-spp-and-candida-spp-in-healthy-subjects-and-patients-with-hepatic-or-renal-impairment-by-monte-carlo-simulation
#3
Xiaowei Zheng, Gaoqi Xu, Liqin Zhu, Luo Fang, Yiwen Zhang, Haiying Ding, Yinghui Tong, Jiao Sun, Ping Huang
The aim of this pharmacokinetic/pharmacodynamic (PK/PD) study is to evaluate the efficacy of various isavuconazole dosing regimens for healthy individuals and patients with hepatic or renal impairment against Aspergillus spp. and Candida spp. Monte Carlo simulations were conducted using pharmacokinetic (PK) parameters and pharmacodynamics (PD) data to determine the probabilities of target attainment and cumulative fractions of response in terms of area under the concentration curve/minimum inhibition concentration (AUC/MIC) targets of isavuconazole...
May 15, 2018: Journal of Clinical Pharmacology
https://www.readbyqxmd.com/read/29759652/the-severity-of-denture-stomatitis-as-related-to-risk-factors-and-different-candida-spp
#4
Mirjana Perić, Rade Živković, Aleksandra Milić Lemić, Milena Radunović, Biljana Miličić, Valentina Arsić Arsenijević
OBJECTIVES: 1) To select patients with Candida-related denture stomatitis (DS) and to study possible risk factors associated with DS, 2) to evaluate the severity of DS according to Newton's classification, and 3) to investigate the association between the presence of non-albicans Candida spp. (NAC) or mixed Candida spp. and the severity of DS. STUDY DESIGN: Eighty-two patients with Candida-positive DS have undergone 1) filling in the interview questionnaire, 2) clinical examination, and 3) microbiologic examination...
March 22, 2018: Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology
https://www.readbyqxmd.com/read/29749387/invasive-candidiasis
#5
REVIEW
Peter G Pappas, Michail S Lionakis, Maiken Cavling Arendrup, Luis Ostrosky-Zeichner, Bart Jan Kullberg
Invasive candidiasis is an important health-care-associated fungal infection that can be caused by several Candida spp.; the most common species is Candida albicans, but the prevalence of these organisms varies considerably depending on geographical location. The spectrum of disease of invasive candidiasis ranges from minimally symptomatic candidaemia to fulminant sepsis with an associated mortality exceeding 70%. Candida spp. are common commensal organisms in the skin and gut microbiota, and disruptions in the cutaneous and gastrointestinal barriers (for example, owing to gastrointestinal perforation) promote invasive disease...
May 11, 2018: Nature Reviews. Disease Primers
https://www.readbyqxmd.com/read/29739588/chemical-composition-antifungal-activity-and-potential-anti-virulence-evaluation-of-the-eugenia-uniflora-essential-oil-against-candida-spp
#6
Joycy Francely Sampaio Dos Santos, Janaína Esmeraldo Rocha, Camila Fonseca Bezerra, Maria Karollyna do Nascimento Silva, Yedda Maria Lobo Soares de Matos, Thiago Sampaio de Freitas, Antonia Thassya Lucas Dos Santos, Rafael Pereira da Cruz, Antonio Júdson Targino Machado, Tigressa Helena Soares Rodrigues, Edy Sousa de Brito, Dédora Lima Sales, Waltécio de Oliveira Almeida, José Galberto Martins da Costa, Henrique Douglas Melo Coutinho, Maria Flaviana Bezerra Morais-Braga
The development of fungal resistance to antifungal drugs has been worsening over the years and as a result research on new antifungal agents derived from plants has intensified. Eugenia uniflora L. (pitanga) has been studied for its various biological actions. In this study the chemical composition and antifungal effects of the E. uniflora essential oil (EULEO) were investigated against Candida albicans (CA), Candida krusei (CK) and Candida tropicalis (CT) standard strains. The essential oil obtained through hydro-distillation was analyzed by gas chromatography coupled to mass spectrometry (GC-MS)...
September 30, 2018: Food Chemistry
https://www.readbyqxmd.com/read/29737225/esophageal-pyogenic-granuloma-a-case-report-and-review-of-the-literature
#7
David A Suarez-Zamora, Paula A Rodriguez-Urrego, Jaime Solano-Mariño, Fernando Sierra-Arango, Mauricio A Palau-Lazaro
Pyogenic granuloma (PG) is a capillary hemangioma mainly found in the skin and oral mucosa, but rarely described in the esophagus. We report the case of a 66-year-old man who consulted for retrosternal pain. Endoscopic studies showed a 28-mm polypoid mass located at the distal esophageal mucosa. The patient underwent endoscopic resection, and the histopathological examination showed a neoplastic proliferation of small blood vessels growing in a lobular architecture, with edematous stroma and prominent inflammatory infiltrate...
May 1, 2018: International Journal of Surgical Pathology
https://www.readbyqxmd.com/read/29735833/echinocandins-their-role-in-the-management-of-candida-biofilms
#8
Subramanian Swaminathan, Shweta Kamat, Nalini Adele Pinto
The importance of antifungal agents and their clinical implications has received little attention in comparison to antibiotics, particularly in the health-care setting. However, apart from bacterial infections rising in hospitals, the incidences of fungal infections are growing with the development of resistance to conventional antifungal agents. Newer antifungal agents such as echinocandins (ECs) have been extensively studied over the past decade and are recognised as a superior treatment compared with prior antifungals as a first line of therapy in tertiary institutions...
January 2018: Indian Journal of Medical Microbiology
https://www.readbyqxmd.com/read/29734032/typing-and-virulence-factors-of-food-borne-candida-spp-isolates
#9
Katarzyna Rajkowska, Alina Kunicka-Styczyńska
Food-borne yeasts, excluding yeasts used as starter cultures, are commonly considered as food spoilage microorganisms. However, the incidence of non-C. albicans Candida (NCAC) infections has increased considerably over the past two decades. Although 15 Candida species are frequently identified as pathogens, a threat to human from food-borne Candida is poorly recognized. In the present study food-borne NCAC were characterized for the virulence factors, known to be associated with yeast pathogenicity. All food-borne strains in planktonic forms and 89% in biofilm structures represented biotypes established for C...
May 3, 2018: International Journal of Food Microbiology
https://www.readbyqxmd.com/read/29729017/risk-assessment-for-the-spread-of-candida-sp-in-dental-chair-unit-waterlines-using-molecular-techniques
#10
Wissame Mazari, Zahia Boucherit-Otmani, Imad Abdelhamid El Haci, Amine Ilahi, Kebir Boucherit
AIMS: The aim of this study was to evaluate the presence of yeasts in dental chair unit waterlines (DCUWLs) and to test their ability to form biofilms. MATERIALS AND METHODS: Eighteen dental waterlines were analysed by culture in liquid Sabouraud in order to allow the quantification and the purification of isolated yeasts from their internal surfaces. All isolates were identified by standard laboratory procedures, including CHROMagar Candida medium for orientation, commercial yeast identification system Api Candida, MALDI-TOF MS and DNA sequencing...
May 4, 2018: International Dental Journal
https://www.readbyqxmd.com/read/29723082/microbial-analysis-of-donor-corneoscleral-rims-and-storage-media
#11
Edmund Tsui, Preston M Luong, Jessa Fogel, Erin S Fogel, Michael E Zegans
PURPOSE: We aim to investigate bacterial and fungal cultures of hypothermic donor corneal storage media (Optisol-GS) and donor rims. METHODS: All corneal transplants performed from January 1, 2015 to June 30, 2016 by a single surgeon at a single facility were retrospectively reviewed. Aerobic, anaerobic, and fungal cultures were routinely obtained from all donor rims and cornea storage media. Culture results and clinical courses were recorded. RESULTS: Eighty-four corneal transplants were performed...
May 3, 2018: Ocular Immunology and Inflammation
https://www.readbyqxmd.com/read/29717970/role-of-biofilm-morphology-matrix-content-and-surface-hydrophobicity-in-the-biofilm-forming-capacity-of-various-candida-species
#12
Anjna Kumari, Sakshi Mankotia, Bhawna Chaubey, Monika Luthra, Rachna Singh
The present study aimed to evaluate the role of biofilm morphology, matrix content and surface hydrophobicity in the biofilm-forming capacity of Candida albicans and non-albicans Candida (NAC) spp. Biofilm formation was determined by microtitre plate assay and bright-field and scanning electron microscopy. The matrix carbohydrates, proteins and e-DNA were quantified by phenol-sulfuric acid, bicinchoninic acid and UV spectroscopy, respectively. Specific glycosyl residues were detected by dot blot. The cell-surface hydrophobicity was determined by hydrocarbon adhesion assay...
May 2, 2018: Journal of Medical Microbiology
https://www.readbyqxmd.com/read/29712651/resistance-to-echinocandins-in-candida-can-be-detected-by-performing-the-etest-directly-on-blood-culture-samples
#13
María Ángeles Bordallo-Cardona, Laura Judith Marcos-Zambrano, Carlos Sánchez-Carrillo, Emilio Bouza, Patricia Muñoz, Pilar Escribano, Jesús Guinea
Background: We examined the rapid evaluation of susceptibility to echinocandins in Candida spp. using the Etest performed directly on positive blood cultures and anidulafungin-containing agar plates. Methods: We prospectively collected 80 positive blood cultures (Bactec™-FX system, Becton-Dickinson, Cockeysville, Maryland, USA) with echinocandin-susceptible Candida spp (n=60) and echinocandin-intermediate C. parapsilosis (n=20) from patients with candidemia. Additionally, blood culture bottles of nonfungemic/bacteremic patients were spiked with 35 echinocandin-resistant Candida spp...
April 30, 2018: Antimicrobial Agents and Chemotherapy
https://www.readbyqxmd.com/read/29707676/mycological-aspects-of-onychomycosis-in-khuzestan-province-iran-a-shift-from-dermatophytes-towards-yeasts
#14
Mahnaz Fatahinia, Sima Jafarpour, Abdollah Rafiei, Simin Taghipour, Koichi Makimura, Ali Rezaei-Matehkolaei
Background and Purpose: Onychomycosis is fungal infection of the nails with an overall increasing incidence, worldwide. The epidemiological aspects of onychomycosis in Khuzestan, Iran, have not been established. In this study, we aimed to evaluate the clinical and mycological status of fungal nail infection in Khuzestan Province, Iran. Materials and Methods: The study population included 433 patients (143 males vs. 290 females). Nail samples underwent primary direct microscopy and culture...
December 2017: Advances in Medical Mycology (Iran)
https://www.readbyqxmd.com/read/29694495/in-vivo-assessment-of-cyto-genotoxic-antigenotoxic-and-antifungal-potential-of-costus-spiralis-jacq-roscoe-leaves-and-stems
#15
Wendel C DE Sousa, Andressa T S Paz, Jamira D Rocha, Edemilson C DA Conceição, Luciane M DE Almeida, Lee C Chen, Leonardo L Borges, Elisa F L C Bailão
Costus spiralis is a Brazilian native plant used in popular medicine, but the safety of this therapeutic use needs investigation. So, the aim of this study was to evaluate the cytogenotoxic and antigenotoxic effects of C. spiralis leaves or stems aqueous extracts on Allium cepa root cells. Moreover, a phytochemical screening and an antioxidant and antifungal activities evaluation were performed. C. spiralis aqueous extracts presented cytotoxicity, but no mutagenicity was observed. When the antigenotoxicity was evaluated, C...
April 23, 2018: Anais da Academia Brasileira de Ciências
https://www.readbyqxmd.com/read/29686548/evaluating-predictors-of-invasive-candidiasis-in-patients-with-and-without-candidemia-on-micafungin
#16
Amy Carr, Peter Colley, Mezgebe Berhe, Hoa L Nguyen
Numerous risk factors have been linked to invasive candidiasis; however, they are nonspecific and often trigger empiric antifungal therapy in a large number of patients. Identification of more precise predictors could promote judicious use of empiric echinocandins. In this retrospective review, 127 patients with blood cultures positive for Candida spp. were compared to a randomly selected cohort of 134 patients on empiric micafungin for ≥3 days and with blood cultures negative for Candida spp. Factors associated with candidemia included total parenteral nutrition (TPN; 26...
January 2018: Proceedings of the Baylor University Medical Center
https://www.readbyqxmd.com/read/29685520/in-vitro-susceptibility-of-candida-spp-to-fluconazole-itraconazole-and-voriconazole-and-the-correlation-between-triazoles-susceptibility-results-from-a-five-year-study
#17
J Lei, J Xu, T Wang
Candida spp. is a common cause of invasive fungal disease. The aim of this study was to examine the susceptibility of Candida spp. to fluconazole, itraconazole and voriconazole and explore the correlation between triazoles susceptibility. The antifungal susceptibility in the present study was measured by ATB Fungus 3 method, and the potential relationship was examined by obtaining the correlation of measured minimal inhibitory concentrations (MICs) of Candida spp. isolates. A total of 2099 clinical isolates of Candida spp...
April 20, 2018: Journal de Mycologie Médicale
https://www.readbyqxmd.com/read/29680320/investigation-of-the-in-vitro-antifungal-and-antibiofilm-activities-of-ceragenins-csa-8-csa-13-csa-44-csa-131-and-csa-138-against-candida-species
#18
Cagla Bozkurt-Guzel, Mayram Hacioglu, Paul B Savage
Cationic steroid antimicrobials (CSA-ceragenin) are a new class of antimicrobial agent. In vitro activities of CSA-8, CSA-13, CSA-44, CSA-131, and CSA-138 and amphotericin B (AMP-B) were assessed against 50 nonrepeat Candida spp. isolates MICs, MFCs and combination studies were determined. Antibiofilm activities of CSAs, AMP-B, 2 azoles, and 2 echinocandins against Candida albicans were performed. Also, effects of coating the wells of plate with selected CSAs and antifungals were measured. The MIC50 (μg/mL) values of CSA-8, CSA-13, CSA-44, CSA-131, CSA-138, and AMP-B were 16, 1, 2, 1, 1, and 1, respectively...
March 28, 2018: Diagnostic Microbiology and Infectious Disease
https://www.readbyqxmd.com/read/29678677/photodynamic-inactivation-of-candida-ssp-on-denture-stomatitis-a-clinical-trial-involving-palatal-mucosa-and-prosthesis-disinfection
#19
André M de Senna, Martha M F Vieira, Rosa Maria Machado-de-Sena, Aparecido O Bertolin, Silvia C Núñez, Martha S Ribeiro
Denture stomatitis (DS) is the most common oral fungal infection in denture wearers. Photodynamic inactivation (PDI) has been showing to be an effective technique in vivo against fungi, including fungal infections in the oral cavity. The disinfection of both oral mucosa and denture may represent a real advantage in terms of fungus control. This clinical study was designed to explore methylene blue (MB)-mediated PDI on oral mucosa and prosthesis of patients with DS. Subjects with DS were divided into two groups...
April 17, 2018: Photodiagnosis and Photodynamic Therapy
https://www.readbyqxmd.com/read/29676728/detection-of-candida-species-in-pregnant-chinese-women-with-a-molecular-beacon-method
#20
Yanhong Zhai, Jing Liu, Li Zhou, Tongzhen Ji, Lingxin Meng, Yang Gao, Ran Liu, Xiao Wang, Lin Li, Binghuai Lu, Zheng Cao
PURPOSE: Candida pathogens are commonly found in women and can cause vulvovaginal candidiasis (VVC), whose infection rate is further increased during pregnancy. We aimed to study the Candida prevalence and strain distribution in pregnant Chinese women with a molecular beacon assay. METHODOLOGY: From March 2016 to February 2017, a total of 993 pregnant women attending routine antenatal visits at the Beijing Obstetrics and Gynecology Hospital were enrolled. For Candida detection and identification, a unique molecular beacon assay was presented and compared with a traditional phenotypic method...
April 20, 2018: Journal of Medical Microbiology
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