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Candida albican

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https://www.readbyqxmd.com/read/29052561/a-bayesian-stepwise-discriminant-model-for-predicting-risk-factors-of-preterm-premature-rupture-of-membranes-a-case-control-study
#1
Li-Xia Zhang, Yang Sun, Hai Zhao, Na Zhu, Xing-De Sun, Xing Jin, Ai-Min Zou, Yang Mi, Ji-Ru Xu
BACKGROUND: Preterm premature rupture of membrane (PPROM) can lead to serious consequences such as intrauterine infection, prolapse of the umbilical cord, and neonatal respiratory distress syndrome. Genital infection is a very important risk which closely related with PPROM. The preliminary study only made qualitative research on genital infection, but there was no deep and clear judgment about the effects of pathogenic bacteria. This study was to analyze the association of infections with PPROM in pregnant women in Shaanxi, China, and to establish Bayesian stepwise discriminant analysis to predict the incidence of PPROM...
October 20, 2017: Chinese Medical Journal
https://www.readbyqxmd.com/read/29051092/a-study-on-the-targeted-surveillance-of-nosocomial-infection-in-intensive-care-units-of-177-hospitals-in-jiangsu-province-of-china
#2
Yang Li, Xiao-Li Cao, Hai Ge, Yi-Hong Jiang, Hong Zhou, Wei Zheng
BACKGROUND: Nosocomial infections (NIs) impact care and costs in hospitals across the globe. There are minimal data on targeted surveillance of NI in intensive care units (ICUs), and data specific to the risk factors for NI are especially limited. METHODS: One hundred seventy-seven secondary and tertiary hospitals performed NI targeted surveillance in their ICUs. The data were collected and summarized by Minke software, then fed back once per quarter. RESULTS: The incidence of NI appeared to decrease, and the incidence of NI per 1000 patient-days and adjusted incidence were 25...
October 16, 2017: Journal of Hospital Infection
https://www.readbyqxmd.com/read/29050594/novel-bioactive-surface-functionalization-of-bacterial-cellulose-membrane
#3
Wei Shao, Jimin Wu, Hui Liu, Shan Ye, Lei Jiang, Xiufeng Liu
Bacterial cellulose (BC) membrane is a promising biopolymer which can be used for tissue implants, wound healing, and drug delivery due to its unique properties, such as high crystallinity, high mechanical strength, ultrafine fiber network structure, good water holding capacity and biocompatibility. However, BC does not intrinsically present antibacterial properties. In the present study, functionalized BC membranes were prepared. FTIR, SEM and XPS were used to characterize the chemical composition and surface morphology...
December 15, 2017: Carbohydrate Polymers
https://www.readbyqxmd.com/read/29050256/in-vitro-and-in-vivo-effects-of-suloctidil-on-growth-and-biofilm-formation-of-the-opportunistic-fungus-candida-albicans
#4
Beini Zeng, Jiachen Li, Yajie Wang, Pengxiang Chen, Xiaohong Wang, Jianfeng Cui, Lidong Liu, Xiaoyan Hu, Qian Cao, Ying Xiao, Junlu Dong, Yundong Sun, Yabin Zhou
As the most frequent fungal pathogen in humans, Candida albicans can develop serious drug resistance because its biofilms are resistant to most antifungal agents; this leads to an urgent need to develop novel antifungals. Here, we evaluated the efficacy of an antithrombotic drug, suloctidil, against C. albicans biofilms in vitro and in vivo. We found that suloctidil is effective to inhibit C. albicans biofilm, with a minimum inhibitory concentration (MIC80) of 4 μg/mL, a biofilm inhibiting concentration (BIC80) of 16 μg/mL and a biofilm eradicating concentration (BEC80) of 64 μg/mL...
September 19, 2017: Oncotarget
https://www.readbyqxmd.com/read/29049184/epidemiology-clinical-characteristics-and-risk-factors-for-mortality-of-early-and-late-onset-invasive-candidiasis-in-intensive-care-units-in-china
#5
Yi Yang, Fengmei Guo, Yan Kang, Bin Zang, Wei Cui, Bingyu Qin, Yingzhi Qin, Qiang Fang, Tiehe Qin, Dongpo Jiang, Bojing Cai, Ruoyu Li, Haibo Qiu
To identify the epidemiology, treatments, outcomes, and risk factors for patients with early- or late-onset invasive candidiasis (EOIC or LOIC) in intensive care units in China.Patients were classified as EOIC (≤10 days) or LOIC (>10 days) according to the time from hospital admission to IC onset to identify distinct clinical characteristics.There were 105 EOIC cases and 201 LOIC cases in this study. EOIC was related to more severe clinical conditions at ICU admission or prior to IC. Significantly, more cases of Candida parapsilosis infection were found in patients with LOIC than in those with EOIC...
October 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29048745/inhibition-of-yeast-to-filamentous-growth-transitions-in-candida-albicans-by-a-small-molecule-inducer-of-mammalian-apoptosis
#6
Joy Goffena, Kurt A Toenjes, David K Butler
The opportunistic fungal pathogen of humans Candida albicans is able to grow in different morphological forms such as round or oval yeasts and filamentous hyphae and pseudohyphae. Morphogenesis, the ability to switch between the yeast and filamentous growth forms, is important for adapting to new microenvironments in the human host and for pathogenesis. The molecular pathways governing morphogenesis are complex and incompletely understood. Previously, we identified several small organic molecules that specifically inhibit the initiation of hyphal growth in C...
October 19, 2017: Yeast
https://www.readbyqxmd.com/read/29047302/a-self-assembled-clavanin-a-coated-amniotic-membrane-scaffold-for-the-prevention-of-biofilm-formation-by-ocular-surface-fungal-pathogens
#7
Santi M Mandal, Jahangir Khan, Denial Mahata, Suman Saha, Jayangshu Sengupta, Osmar N Silva, Subhayan Das, Mahitosh Mandal, Octavio L Franco
Amniotic membrane (AM) is frequently used in ophthalmologic surgery for rapid ocular surface reconstruction. Sometimes it may create a major problem with associated infections after biofilm formation over the membrane. To overcome this problem, AM was coated with the antimicrobial peptide clavanin A. The antifungal activity of clavanin A in the native and self-assembled form was determined against the common ocular surface pathogens Candida albicans, Aspergillus fumigatus, Alternaria sp. and Fusarium sp. Biofilm formation over the coated surface was significantly reduced in comparison with the uncoated membrane...
October 19, 2017: Biofouling
https://www.readbyqxmd.com/read/29047237/proteus-vulgaris-and-proteus-mirabilis-decrease-candida-albicans-biofilm-formation-by-suppressing-morphological-transition-to-its-hyphal-form
#8
Kyoung Ho Lee, Su Jung Park, Sun Ju Choi, Joo Young Park
PURPOSE: Candida albicans (C. albicans) and Proteus species are causative agents in a variety of opportunistic nosocomial infections, and their ability to form biofilms is known to be a virulence factor. In this study, the influence of co-cultivation with Proteus vulgaris (P. vulgaris) and Proteus mirabilis (P. mirabilis) on C. albicans biofilm formation and its underlying mechanisms were examined. MATERIALS AND METHODS: XTT reduction assays were adopted to measure biofilm formation, and viable colony counts were performed to quantify yeast growth...
November 2017: Yonsei Medical Journal
https://www.readbyqxmd.com/read/29046411/rapid-detection-and-differentiation-of-clinically-relevant-candida-species-simultaneously-from-blood-culture-using-a-novel-signal-amplification-approach
#9
Wanyuan Ao, Joshua Klonoski, Eric Berlinghoff, Jordan Jensen, Taliman Afroz, Denton Munns, Wes Lindsey, Gerald Denys, Robert Jenison
Fungal blood-stream infections are a significant problem in the U.S. with an attributable mortality rate of up to 40%. Early diagnosis to direct appropriate therapy has been shown to be critical to reduce mortality rates. Conventional phenotypic methods for fungal detection take several days, which is often too late to impact outcomes. Herein, we describe a cost-effective multiplex assay platform for rapid detection and differentiation of major clinically relevant Candida species directly from blood culture...
October 18, 2017: Journal of Clinical Microbiology
https://www.readbyqxmd.com/read/29043893/considerations-on-risk-of-bacterial-vaginosis-trichomonas-vaginalis-and-candida-albicans-infection-among-new-users-of-combined-hormonal-contraception-vs-lng-ius
#10
Ahmed M Abbas, Asmaa S Shaltout
No abstract text is available yet for this article.
October 18, 2017: European Journal of Contraception & Reproductive Health Care
https://www.readbyqxmd.com/read/29043360/synthesis-photophysical-and-biological-properties-of-a-new-oxazolone-fluorescent-probe-for-bioimaging-an-experimental-and-theoretical-study
#11
Przemysław Krawczyk, Beata Jędrzejewska, Piotr Cysewski, Tomasz Janek
In this study, a new oxazolone derivative 4-{N,N-bis[2-phenyl-4-benzylidene-1,3-oxazol-5(4H)-one]amino}benzaldehyde (PB3) was synthesized and investigated as a fluorescent dye. The spectroscopic properties in different solvents were thoroughly studied. The experimental data were supported by quantum-chemical calculations using density functional theory. Measurements and theoretical calculations showed that the PB3 dye is characterized by non-monotonic solvatochromism, a strongly polar charge transfer excited state, a large Stokes' shift, a high fluorescence quantum yield and a high fluorescence lifetime...
October 18, 2017: Organic & Biomolecular Chemistry
https://www.readbyqxmd.com/read/29043218/evaluation-of-antioxidant-and-antimicrobial-activities-of-ethanol-extracts-of-three-kinds-of-strawberries
#12
Semeneh Seleshe, Jong Seok Lee, Sarah Lee, Hye Jin Lee, Ga Ryun Kim, Joohong Yeo, Jong Yea Kim, Suk Nam Kang
The antioxidant and antimicrobial activities of three kinds of strawberry ethanol extracts from Robus corchorifolius L. f. (RCL), Rubus parvifolius L. var. parvifolius (RPL), and Duchesnea chrysantha Miq. (DCM) were investigated. The RPL was highest (P<0.05) in phenolic, flavonoid, and anthocyanin contents. 2,2-Diphenyl-1-picrylhydrazyl and 2,2'-azino-bis(3-ethylbenzothiazoline-6-sulphonic acid) radical scavenging activities of RPL and DCM extracts were higher than that of RCL (P<0.05). Hydrogen peroxide scavenging activity of RPL was high compared to DCM and RCL (P<0...
September 2017: Preventive Nutrition and Food Science
https://www.readbyqxmd.com/read/29042733/effect-of-melaleuca-alternifolia-mixed-with-tissue-conditioners-in-varying-doses-on-colonization-and-inhibition-of-candida-albicans-an-in-vitro-study
#13
Siva Kumar Vankadara, Rajendra Basavaraj Hallikerimath, Viraj Patil, Kishore Bhat, Mallikarjun Hanumantappa Doddamani
AIMS AND OBJECTIVES: The study was conducted to evaluate the Colonization & Inhibition of Candida albicans in selected commercially available denture lining materials material by mixing them with varying concentrations and doses of tea tree oil. MATERIALS AND METHODS: Five test discs of 10mm diameter and 1.5mm thickness were prepared using commercially available soft denture lining materials (Viscogel and GC-soft). Tea tree oil of varying concentrations (10%, 20%, 30%, and 40%) and doses (0...
July 2017: Contemporary Clinical Dentistry
https://www.readbyqxmd.com/read/29040806/bacterial-derived-carbohydrates-bind-cyr1-and-trigger-hyphal-growth-in-candida-albicans
#14
Jason Burch, Siavash Mashayekh, Dennis D Wykoff, Catherine Leimkuhler Grimes
The dimorphic yeast Candida albicans is the most common pathologic fungus found in humans. While this species is normally commensal, a morphological switch from budding yeast to filamentous hyphae allows the fungi to invade epithelial cells and cause infections. The phenotypic change is controlled by the adenylyl cyclase, Cyr1. Interestingly, this protein contains a leucine-rich repeat (LRR) domain, which is commonly found in innate immune receptors from plants and animals. A functional and pure LRR domain was obtained in high yields from E...
October 17, 2017: ACS Infectious Diseases
https://www.readbyqxmd.com/read/29040636/vt-1161-protects-mice-against-oropharyngeal-candidiasis-caused-by-fluconazole-susceptible-and-resistant-candida-albicans
#15
Timothy J Break, Jigar V Desai, Mukil Natarajan, Elise M N Ferre, Christina Henderson, Adrian M Zelazny, Ulrich Siebenlist, William J Hoekstra, Robert J Schotzinger, Edward P Garvey, Michail S Lionakis
Background: Candida albicans, the most common human fungal pathogen, causes chronic mucosal infections in patients with inborn errors of IL-17 immunity that rely heavily on chronic, often lifelong, azole antifungal agents for treatment. However, a rise in azole resistance has predicated a need for developing new antifungal drugs. Objectives: To test the in vitro and in vivo efficacy of VT-1161 and VT-1129 in the treatment of oropharyngeal candidiasis with azole-susceptible or -resistant C...
October 10, 2017: Journal of Antimicrobial Chemotherapy
https://www.readbyqxmd.com/read/29039220/function-of-glutaredoxin-3-grx3-in-oxidative-stress-response-caused-by-iron-homeostasis-disorder-in-candida-albicans
#16
Dan Zhang, Yijie Dong, Qilin Yu, Zhang Kai, Meng Zhang, Chang Jia, Chenpeng Xiao, Bing Zhang, Biao Zhang, Mingchun Li
AIM: Glutaredoxin is a conserved oxidoreductase in eukaryotes and prokaryotes. This study aimed to determine the role of Grx3 in cell survival, iron homeostasis and the oxidative stress response in Candida albicans. MATERIALS & METHODS: A grx3Δ/Δ mutant was obtained using PCR-mediated homologs recombination. The function of Grx3 was investigated by a series of biochemical methods. RESULTS: Deletion of GRX3 impaired growth and cell cycle, disturbance of iron homeostasis and activated the oxidative stress response...
October 17, 2017: Future Microbiology
https://www.readbyqxmd.com/read/29038279/a-ctg-clade-candida-yeast-genetically-engineered-for-the-genotype-phenotype-characterization-of-azole-antifungal-resistance-in-human-pathogenic-yeasts
#17
Isabelle Accoceberry, Amandine Rougeron, Nicolas Biteau, Pauline Chevrel, Valérie Fitton-Ouhabi, Thierry Noël
A strain of the opportunistic pathogenic yeast Candida lusitaniae was genetically modified for its use as a cellular model for assessing by allele replacement the impact of lanosterol C14α-demethylase ERG11 mutations on azole resistance. Candida lusitaniae was chosen because it is susceptible to azole antifungals, it belongs to the CTG clade of yeast which includes most of the Candida species pathogenic for humans, and it is haploid and easily amenable to genetic transformation and molecular modeling. In this work, allelic replacement is targeted at the ERG11 locus by the reconstitution of a functional auxotrophic marker in the 3' intergenic region of ERG11 Homologous and heterologous ERG11 alleles are expressed from the resident ERG11 promoter of C...
October 16, 2017: Antimicrobial Agents and Chemotherapy
https://www.readbyqxmd.com/read/29038271/evaluation-of-antifungal-efficacy-of-three-new-cyclic-lipopeptides-of-the-class-bacillomycin-from-bacillus-subtilis-rlid-12-1
#18
Ramya R, Manjari Shrivastava, Namitha N N, Ram Lal Thakur, Arunaloke Chakrabarti, Utpal Roy
New lipopeptide homologues (AF3, AF4 and AF5) with antifungal activities against Candida and Cryptococcus spp. were purified from the cell free supernatant of Bacillus subtilis RLID 12.1. The lipopeptides AF3, AF4 and AF5 were identified with the same peptide sequence Asn-Pro-Tyr-Asn-Gln-Thr-Ser with variations in the fatty acid branching type and chain length (anteiso-C17, iso-C17 and iso-C18 respectively). Comparing the three homologues for minimum inhibitory concentrations (MIC) against 81 Candida (64 no...
October 16, 2017: Antimicrobial Agents and Chemotherapy
https://www.readbyqxmd.com/read/29032925/current-status-of-the-etiology-of-candidiasis-in-mexico
#19
María Del Rocío Reyes-Montes, Esperanza Duarte-Escalante, Erick Martínez-Herrera, Gustavo Acosta-Altamirano, María Guadalupe Frías-De León
This study presents a systematic review of the literature on the etiology of superficial and invasive candidiasis in Mexico reported from 2005 to 2015. The data have shown that Candida albicans is the most prevalent species with an increasing tendency of the non-C. albicans Candida species, as reported in other countries. The use of phenotypical methods in the identification of the yeasts limits the identification at the species level, particularly in species that are part of complexes, this is important because the identification only at the genus level leads to inadequate treatment due to the different susceptibility to the antifungals among species...
October 9, 2017: Revista Iberoamericana de Micología
https://www.readbyqxmd.com/read/29032075/synthesis-structures-and-esi-mass-studies-of-silver-i-derivatives-of-imidazolidine-2-thiones-antimicrobial-potential-and-biosafety-evaluation
#20
Jaspreet K Aulakh, Tarlok S Lobana, Henna Sood, Daljit S Arora, Victoria A Smolinski, Courney E Duff, Jerry P Jasinski
The basic objective of this investigation is to explore potential metallo-organic antimicrobial agents based on silver-heterocyclic-2-thiones. In this respect, a series of silver(I) halide complexes with imidazolidine-2-thiones (L-NR, R=H, Me, Et, Pr(n), Bu(n), Ph), namely, mononuclear [AgX(L-NR)(PPh3)2] (X, R: Cl, Bu, 1; Br, Ph, 7); [AgX(L-NR)3] (Br, Bu, 5; Br, Pr(n), 8) and halogen bridged dinuclear [Ag2(μ-X)2(L-NR)2(PPh3)2] (Cl, Bu(n), 2; Cl, Ph, 3; Cl, Pr(n), 4; Br, Ph, 6) have been synthesized and characterized using modern techniques...
October 7, 2017: Journal of Inorganic Biochemistry
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