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Candida albican

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https://www.readbyqxmd.com/read/29928583/proteomic-analysis-of-a-candida-albicans-pga1-null-strain
#1
Andy Awad, Pamela El Khoury, Brigitte Wex, Roy A Khalaf
We previously characterized Pga1, a Candida albicans ( C. albicans ) cell wall protein necessary for proper virulence, adhesion, and resistance to oxidative stress. By utilizing tandem mass spectrometry coupled with bioinformatics to investigate cell wall proteome expression in a pga1 null fourteen and 36 proteins were identified in the wild type grown under filamentous and non-filamentous conditions respectively, but were not detected in the mutant, including members of the PGA GPI anchored family. Virulence and adhesion proteins such as Hsp 90, Sap10, Cdc11, Int 3 and members of the lipase family were also identified exclusively in the wild type...
June 2018: EuPA Open Proteomics
https://www.readbyqxmd.com/read/29927214/-inpatient-candiduria-etiology-susceptibility-to-antifungal-drugs-and-risk-factors
#2
G Jiménez-Guerra, I Casanovas Moreno-Torres, M Gutiérrez-Soto, F Vazquez-Alonso, A Sorlózano-Puerto, J M Navarro-Marí, J Gutiérrez-Fernández
OBJECTIVE: Candida could become the second most frequent cause of nosocomial urinary tract infection. Although Candida albicans is the most important species, others have arisen as emerging pathogens. The aim of this study was to analyze the presence of candiduria in inpatients. METHODS: We performed a retrospective study of Candida isolates from adult inpatient urocultures over five years, gathering and tabulating data on: the species; susceptibility to fluconazole, amphotericin B, and voriconazole (Vitek2, BioMerieux); presence of catheter; hospital department of origin; and patient age and sex...
June 20, 2018: Revista Española de Quimioterapia: Publicación Oficial de la Sociedad Española de Quimioterapia
https://www.readbyqxmd.com/read/29925728/peel-bond-strength-and-antifungal-activity-of-two-soft-denture-lining-materials-incorporated-with-1-chlorhexidine-diacetate
#3
Nathalia Albrecht, Tatiana Kelly DA Silva Fidalgo, Maria José Santos DE Alencar, Lucianne Cople Maia, Vanessa Migliorini Urban, Karin Hermana Neppelenbroek, Kátia Rodrigues Reis
Two soft denture lining materials (SC-Soft Confort and TS-Trusoft) were investigated with and without the addition of 1.0% of chlorhexidine diacetate (1.0% CHX). To assess peel bond strength, specimens (75×10×6 mm) were submitted to a peel test at 10 mm/min immediately and after 24 h. To evaluate Candida albicans growth inhibition, disc of specimens (10×3 mm) were immersed in a solution with 3×106 CFU/mL of C. albicans, and spectral measurements were made following immersion in MTT solution for 2, 4, and 6 days...
June 20, 2018: Dental Materials Journal
https://www.readbyqxmd.com/read/29924230/presence-of-candida-spp-and-candidiasis-in-liver-transplant-patients
#4
Samantha Bertoncello Dos Santos, Clarice Elvira Saggin Sabadin, Débora Nunes Mario, Lilian Rigo, Dulce Aparecida Barbosa
BACKGROUND: Candidiasis is the most common opportunistic fungal infection of the oral cavity caused by fungi of the genus Candida and usually associated with immunosuppressed individuals. OBJECTIVES: To evaluate the presence of oral candidiasis and identify the presence of Candida spp. in liver transplant recipients and assess the association between the presence of the fungus and sociodemographic variables, dietary habits and environmental exposure. METHODS: A cross-sectional study was performed with 49 patients who had undergone liver transplants at Hospital São Vicente de Paulo in Passo Fundo - RS...
June 2018: Anais Brasileiros de Dermatologia
https://www.readbyqxmd.com/read/29923610/incorporation-of-the-microencapsulated-antimicrobial-agent-phytoncide-into-denture-base-resin
#5
S An, R B Judge, R H Wong, M H Arzmi, J E Palamara, S G Dashper
BACKGROUND: This study aimed to fabricate a denture base resin (DBR) containing phytoncide microcapsules (PTMCs) and determine the mechanical properties of the resin and antifungal activity. METHODS: Fifty-four heat cured rectangular DBR specimens (64 x 10 x 3.3 ± 0.2 mm) containing nine concentrations of PTMC between 0 - 5% (wt/wt) were fabricated and subjected to a three-point bending test. A phytoncide release bioassay was developed using DBR containing 0% and 2...
June 20, 2018: Australian Dental Journal
https://www.readbyqxmd.com/read/29922855/hyporientalin-a-an-anti-candida-peptaibol-from-a-marine-trichoderma-orientale
#6
Ines Touati, Nicolas Ruiz, Olivier Thomas, Irina S Druzhinina, Lea Atanasova, Olfa Tabbene, Salem Elkahoui, Roudaina Benzekri, Lamjed Bouslama, Yves François Pouchus, Ferid Limam
A Trichoderma orientale strain LSBA1 was isolated from the Mediterranean marine sponge Cymbaxinella damicornis. The crude extract of T. orientale mycelium showed inhibitory activity against growth of Gram-positive and Gram-negative bacteria as well as clinical isolates of Candida albicans. Purification of the anti-Candida component was performed using a combination of open silica gel-60 column and reverse phase high performance liquid chromatography. The active compound called hyporientalin A has been identified as a peptaibol analogue of longibrachin-A-II using mass spectrometry...
June 19, 2018: World Journal of Microbiology & Biotechnology
https://www.readbyqxmd.com/read/29922600/iron-at-the-centre-of-candida-albicans-interactions
#7
REVIEW
Ruan Fourie, Oluwasegun O Kuloyo, Bonang M Mochochoko, Jacobus Albertyn, Carolina H Pohl
Iron is an absolute requirement for both the host and most pathogens alike and is needed for normal cellular growth. The acquisition of iron by biological systems is regulated to circumvent toxicity of iron overload, as well as the growth deficits imposed by iron deficiency. In addition, hosts, such as humans, need to limit the availability of iron to pathogens. However, opportunistic pathogens such as Candida albicans are able to adapt to extremes of iron availability, such as the iron replete environment of the gastrointestinal tract and iron deficiency during systemic infection...
2018: Frontiers in Cellular and Infection Microbiology
https://www.readbyqxmd.com/read/29922262/multi-locus-next-generation-sequence-typing-of-dna-extracted-from-pooled-colonies-detects-multiple-unrelated-candida-albicans-strains-in-a-significant-proportion-of-patient-samples
#8
Ningxin Zhang, David Wheeler, Mauro Truglio, Cristina Lazzarini, Jenine Upritchard, Wendy McKinney, Karen Rogers, Anna Prigitano, Anna M Tortorano, Richard D Cannon, Roland S Broadbent, Sally Roberts, Jan Schmid
The yeast Candida albicans is an important opportunistic human pathogen. For C. albicans strain typing or drug susceptibility testing, a single colony recovered from a patient sample is normally used. This is insufficient when multiple strains are present at the site sampled. How often this is the case is unclear. Previous studies, confined to oral, vaginal and vulvar samples, have yielded conflicting results and have assessed too small a number of colonies per sample to reliably detect the presence of multiple strains...
2018: Frontiers in Microbiology
https://www.readbyqxmd.com/read/29921973/bandgap-tunable-agins-based-quantum-dots-for-high-contrast-cell-imaging-with-enhanced-photodynamic-and-antifungal-applications
#9
Irshad Ahmad Mir, V S Radhakrishanan, Kamla Rawat, Tulika Prasad, H B Bohidar
Herein, we report a facile microwave-assisted synthesis of cadmium-free water-soluble silver indium sulfide (AgInS2 or AIS) and AgInS@ZnS (or AIS@ZnS) core-shell quantum dots (QDs) using glutathione (GSH) as stabilizer. The core and core-shell nanocrystals exhibit tunable bandgap ranging of 2.3-3.1 and 2.4-3.5 eV, mean particle size of 2.5 and 3.25 nm, quantum yield of 26% and 49%, and fluorescence lifetimes of 326 and 438 ns, respectively. The core-shell QDs exhibit color-tunable emission in the visible region (500 to 600 nm), where the tunability was achieved by varying the molar ratio of Ag:In in the precursors...
June 19, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29920785/epidemiology-of-fungaemia-in-sweden-a-nationwide-retrospective-observational-survey
#10
Lena Klingspor, Måns Ullberg, Johan Rydberg, Nahid Kondori, Lena Serrander, Jonas Swanberg, Kenneth Nilsson, Cecilia Jendle Bengtén, Marcus Johansson, Margareta Granlund, Eva Törnqvist, Anders Nyberg, Karin Kindlund, Minna Ygge, Dalila Kartout-Boukdir, Michael Toepfer, Eva Hålldin, Gunnar Kahlmeter, Volkan Özenci
OBJECTIVES: To identify the epidemiology and antifungal susceptibilities of Candida spp. among blood culture isolates and to describe the epidemiology of fungal meningitis in Sweden. METHODS: The study was a retrospective, observational nationwide laboratory-based surveillance for fungaemia and fungal meningitis and was conducted from September 2015 to August 2016. RESULTS: In total, 488 Candida blood culture isolates were obtained from 471 patients (58% males)...
June 19, 2018: Mycoses
https://www.readbyqxmd.com/read/29915571/the-impact-of-biofilm-formation-on-the-persistence-of-candidemia
#11
Wei-Sin Li, Yi-Chun Chen, Shu-Fang Kuo, Fang-Ju Chen, Chen-Hsiang Lee
This study aimed to determine the predictors of persistent candidemia and examine the impact of biofilm formation by Candida isolates in adult patients with candidemia. Of the adult patients with candidemia in Kaohsiung Chang Gung Memorial Hospital between January 2007 and December 2012, 68 case patients with persistent candidemia (repeated candidemia after a 3-day systemic antifungal therapy) and 68 control patients with non-persistent candidemia ( Candida clearance from the bloodstream after a 3-day systemic antifungal therapy) were included based on propensity score matching and matching for the Candida species isolated...
2018: Frontiers in Microbiology
https://www.readbyqxmd.com/read/29915284/d-cateslytin-a-new-antifungal-agent-for-the-treatment-of-oral-candida-albicans-associated-infections
#12
Pauline Dartevelle, Claire Ehlinger, Abdurraouf Zaet, Christian Boehler, Morgane Rabineau, Benoit Westermann, Jean-Marc Strub, Sarah Cianferani, Youssef Haïkel, Marie-Hélène Metz-Boutigue, Céline Marban
The excessive use of antifungal agents, compounded by the shortage of new drugs being introduced into the market, is causing the accumulation of multi-resistance phenotypes in many fungal strains. Consequently, new alternative molecules to conventional antifungal agents are urgently needed to prevent the emergence of fungal resistance. In this context, Cateslytin (Ctl), a natural peptide derived from the processing of Chromogranin A, has already been described as an effective antimicrobial agent against several pathogens including Candida albicans...
June 18, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29913547/the-roles-of-hsp90-calcineurin-pathway-inthe-antifungal-activity-of-honokiol
#13
Kai Liao, Lingmei Sun
Honokiol, a bioactive compound isolated from the cone and bark of Magnolia officinalis , has been shown to have various activities including the inhibitionof the growth of Candida albicans . We here investigated the roles of Hsp90-calcineurin pathway in the antifungal activity of honokiol.The pharmacologic tool was employed to evaluate the effect of Hsp90 and calcineurin in the antifungal activity of honokiol. We also evaluated the protective effects of calcineurin inhibitor cyclosporin A (CsA) on honokiol-induced mitochondrial dysfunction by fluorescence staining method...
May 8, 2018: Journal of Microbiology and Biotechnology
https://www.readbyqxmd.com/read/29913479/prioritizing-and-modelling-of-putative-drug-target-proteins-of-candida-albicans-by-systems-biology-approach
#14
Tariq Ismail, Nighat Fatima, Syed Aun Muhammad, Syed Saoud Zaidi, Nisar Rehman, Izhar Hussain, Najam Us Sahr Tariq, Imran Amirzada, Abdul Mannan
Candida albicans (Candida albicans) is one of the major sources of nosocomial infections in humans which may prove fatal in 30% of cases. The hospital acquired infection is very difficult to treat affectively due to the presence of drug resistant pathogenic strains, therefore there is a need to find alternative drug targets to cure this infection. In silico and computational level frame work was used to prioritize and establish antifungal drug targets of Candida albicans. The identification of putative drug targets was based on acquiring 5090 completely annotated genes of Candida albicans from available databases which were categorized into essential and non-essential genes...
2018: Acta Biochimica Polonica
https://www.readbyqxmd.com/read/29913161/the-solution-structure-of-ccl28-reveals-structural-lability-that-does-not-constrain-antifungal-activity
#15
Monica A Thomas, Jie He, Francis C Peterson, Anna R Huppler, Brian F Volkman
The chemokine CCL28 is constitutively expressed in mucosal tissues and is abundant in low-salt mucosal secretions. Beyond its traditional role as a chemoattractant, CCL28 has been shown to act as a potent and broad-spectrum antimicrobial agent with particular efficacy against the commensal fungus and opportunistic pathogen Candida albicans. However, the structural features that allow CCL28 to perform its chemotactic and antimicrobial functions remain unknown. Here, we report the structure of CCL28, solved using nuclear magnetic resonance spectroscopy...
June 15, 2018: Journal of Molecular Biology
https://www.readbyqxmd.com/read/29912894/impact-of-surface-topography-on-biofilm-formation-by-candida-albicans
#16
Katherine Lagree, Htwe H Mon, Aaron P Mitchell, William A Ducker
Candida albicans is a fungal pathogen that causes serious biofilm-based infections. Here we have asked whether surface topography may affect C. albicans biofilm formation. We tested biofilm growth of the prototypical wild-type strain SC5314 on a series of polydimethylsiloxane (PDMS) solids. The surfaces were prepared with monolayer coatings of monodisperse spherical silica particles that were fused together into a film using silica menisci. The surface topography was varied by varying the diameter of the silica particles that were used to form the film...
2018: PloS One
https://www.readbyqxmd.com/read/29912040/incidence-and-outcomes-of-positive-donor-rim-cultures-and-infections-in-the-cornea-preservation-time-study
#17
Shahzad I Mian, Anthony J Aldave, Elmer Y Tu, Brandon D Ayres, Bennie H Jeng, Marian S Macsai, Michael L Nordlund, Jeffrey G Penta, Sudeep Pramanik, Loretta B Szczotka-Flynn, Allison R Ayala, Wendi Liang, Maureen G Maguire, Jonathan H Lass
PURPOSE: To assess donor rim culture results and outcomes of ocular infections in the Cornea Preservation Time Study (CPTS). METHODS: Donor corneal rim cultures were optional. Donor characteristics were assessed for association with positive cultures using the Fisher exact test and Poisson regression analyses. Incidence rates of ocular infections were estimated, and 95% confidence intervals were calculated. RESULTS: Cultures were performed in 784 (58...
June 14, 2018: Cornea
https://www.readbyqxmd.com/read/29911057/antifungal-efficacy-and-the-mechanical-properties-of-soft-liners-against-candida-albicans-after-the-incorporation-of-garlic-and-neem-an-in-vitro-study
#18
Seenivasan Madhan Kumar, V Anand Kumar, Parathasarthy Natarajan, Gayathri Sreenivasan
Objectives: To evaluate the in vitro growth inhibition of Candida albicans , in the soft-liner material and Shore A hardness from resin-based denture soft lining materials modified by neem or garlic incorporation. Materials and Methods: Resin discs were prepared with poly methyl methacrylate (PMMA) and soft liners incorporated with varying concentrations of neem or garlic. For antifungal activity, resin discs were placed on agar plates inoculated with C. albicans and were evaluated after 2, 4, and 7 days using the streaking method...
May 2018: Journal of International Society of Preventive & Community Dentistry
https://www.readbyqxmd.com/read/29910625/epidemiology-practice-patterns-and-prognostic-factors-for-candidemia-and-characteristics-of-fourteen-patients-with-breakthrough-candida-bloodstream-infections-a-single-tertiary-hospital-experience-in-japan
#19
Ryuichi Hirano, Yuichi Sakamoto, Junichi Kitazawa, Shoji Yamamoto, Hiroyuki Kayaba
Background: Candidemia is associated with high mortality, and its prognostic factors need to be examined in more detail in order to improve its management. A case of breakthrough (BT) candidemia is defined as the development of candidemia during antifungal therapy. The microbiological characteristics of and appropriate clinical practices for BT candidemia remain unclear. Objectives: The primary objective of the present study was to identify the prognostic factors of candidemia, while the secondary objective was to elucidate the microbiological characteristics of patients with BT candidemia...
2018: Infection and Drug Resistance
https://www.readbyqxmd.com/read/29909005/accuracy-of-sensititre-yeastone-echinocandins-epidemiological-cut-off-values-for-identification-of-fks-mutant-candida-albicans-and-candida-glabrata-a-ten-year-national-survey-of-the-fungal-infection-network-of-switzerland-funginos
#20
A Kritikos, D Neofytos, N Khanna, P W Schreiber, K Boggian, J Bille, J Schrenzel, K Mühlethaler, R Zbinden, T Bruderer, D Goldenberger, G Pfyffer, A Conen, C Van Delden, S Zimmerli, D Sanglard, D Bachmann, O Marchetti, F Lamoth
OBJECTIVES: Echinocandins represent the first-line treatment of candidemia. Acquired echinocandin resistance is mainly observed among Candida albicans and glabrata and is associated with FKS hotspot mutations. The commercial Sensititre YeastOneTM (SYO) kit is widely used for antifungal susceptibility testing, but interpretive clinical breakpoints are not well defined. We determined echinocandins epidemiological cut-off values (ECV) for C. albicans/glabrata tested by SYO and assessed their ability to identify FKS mutants in a national survey of candidemia...
June 14, 2018: Clinical Microbiology and Infection
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