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Candida albican

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https://www.readbyqxmd.com/read/28431022/cpp1-phosphatase-mediated-signaling-crosstalk-between-hog1-and-cek1-mitogen-activated-protein-kinases-is-involved-in-the-phenotypic-transition-in-candida-albicans
#1
Fu-Sheng Deng, Ching-Hsuan Lin
Cellular signaling pathways involved in cell growth and differentiation mediated by mitogen-activated protein kinase (MAPK) cascades have been well characterized in fungi. However, the mechanisms of signaling crosstalk between MAPKs to ensure signaling specificity are largely unknown. Previous work showed that activation of the Candida albicans Cek1 MAPK pathway resulted in opaque cell formation and filamentation, which mirrored the phenotypes to hog1Δ. Additionally, deleting the HOG1 gene stimulated Cek1p...
April 20, 2017: Medical Mycology: Official Publication of the International Society for Human and Animal Mycology
https://www.readbyqxmd.com/read/28430797/effect-of-quinoline-based-1-2-3-triazole-and-its-structural-analogues-on-growth-and-virulence-attributes-of-candida-albicans
#2
Mohammad Irfan, Shadab Alam, Nikhat Manzoor, Mohammad Abid
Candida albicans, along with some other non-albicans Candida species, is a group of yeast, which causes serious infections in humans that can be both systemic and superficial. Despite the fact that extensive efforts have been put into the discovery of novel antifungal agents, the frequency of these fungal infections has increased drastically worldwide. In our quest for the discovery of novel antifungal compounds, we had previously synthesized and screened quinoline containing 1,2,3-triazole (3a) as a potent Candida spp inhibitor...
2017: PloS One
https://www.readbyqxmd.com/read/28429365/a-randomized-clinical-trial-about-presence-of-pathogenic-microflora-and-risk-of-peri-implantitis-comparison-of-two-different-types-of-implant-abutment-connections
#3
F Mencio, F De Angelis, P Papi, D Rosella, G Pompa, S Di Carlo
OBJECTIVE: The aim of this in vivo study was to evaluate two different types of implant-abutment connections: screwed connection and cemented connection, analyzing peri-implant bacteria microflora as well as other clinical parameters. PATIENTS AND METHODS: Twenty implants were selected, inserted in 20 patients, 10 with a screwed implant-abutment connection (Group 1) and 10 with a cemented implant-abutment connection (Group 2). The peri-implant microflora was collected, after at least 360 days from the prosthetic rehabilitation, using paper points inserted in peri-implant sulcus for 30 s...
April 2017: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/28429308/chronic-candidiasis-in-children
#4
REVIEW
Laura Green, William K Dolen
PURPOSE OF REVIEW: Healthy children may develop candidal infections as the result of exposure to antibiotics or corticosteroids, but chronic candidiasis in children after the newborn period is unusual. Chronic mucocutaneous candidiasis (CMC) refers to a group of conditions characterized by recurrent or persistent infections with Candida species, particularly Candida albicans. CMC is a phenotype observed in a spectrum of immunologic disorders, some with endocrinologic and autoimmune features...
May 2017: Current Allergy and Asthma Reports
https://www.readbyqxmd.com/read/28428132/novel-properties-of-hippophae-rhamnoides-l-twig-and-leaf-extracts-anti-virulence-action-and-synergy-with-antifungals-studied-in-vitro-on-candida-spp-model
#5
Beata Sadowska, Aleksandra Budzyńska, Anna Stochmal, Jerzy Żuchowski, Barbara Różalska
Original, chemically characterized Sea buckthorn (SBT) twig and leaf extracts were in vitro studied in terms of anti-Candida activity. Minimum inhibitory concentrations (MICs) of the extracts against C. albicans ATCC 10231 ranged: 250 μg/ml (twig), 31.5 μg/ml (leaf), and against C. glabrata G1 (clinical isolate) - 15.6 μg/ml (twig), 3.9 μg/ml (leaf). Next the extracts have been used at their subMIC. Both extracts significantly enhanced activity of fluconazole (FLC) and caspofungin (CAS) against C. albicans and increased their efficacy against C...
April 17, 2017: Microbial Pathogenesis
https://www.readbyqxmd.com/read/28428067/targeting-and-synergistic-action-of-an-antifungal-peptide-in-an-antibiotic-drug-delivery-system
#6
Seong-Cheol Park, Young-Min Kim, Jong-Kook Lee, Nam-Hong Kim, Eun-Ji Kim, Hun Heo, Min-Young Lee, Jung Ro Lee, Mi-Kyeong Jang
Amphotericin B (AmB) has been widely used against fungal infections throughout almost the entire body, including the skin, nails, oral cavity, respiratory tract, and urinary tract. However, the development of AmB-loaded nanoparticles demands a novel technique that reduces its toxicity and other associated problems. Here, we developed a pH-responsive and redox-sensitive polymer-based AmB-delivery carrier system. In particular, this system was functionalized by conjugation with the antifungal peptide histatin 5, which acts both as a targeting ligand and a synergistic antifungal molecule against Candida albicans, a major systemic fungal pathogen of humans...
April 17, 2017: Journal of Controlled Release: Official Journal of the Controlled Release Society
https://www.readbyqxmd.com/read/28426852/an-outbreak-of-endogenous-fungal-endophthalmitis-among-intravenous-drug-abusers-in-new-england
#7
Aubrey R Tirpack, Jay S Duker, Caroline R Baumal
Importance: Intravenous drug abuse (IVDA) is a known risk factor for endogenous fungal endophthalmitis (EFE), a severe intraocular infection caused by hematogenous seeding of mycotic organisms to the eye. Reporting significant increases in heroin-related deaths since 2014, the New England region is in the midst of an opioid crisis that has led to a substantial increase in patients at risk for this vision-threatening disease. Objective: To present an update on characteristics, management, and visual outcomes in patients with EFE...
April 20, 2017: JAMA Ophthalmology
https://www.readbyqxmd.com/read/28426292/efficacy-of-three-different-lasers-on-eradication-of-enterococcus-faecalis-and-candida-albicans-biofilms-in-root-canal-system
#8
Silvija Kasić, Marita Knezović, Nataša Beader, Dragana Gabrić, Ana Ivanišević Malčić, Anja Baraba
OBJECTIVE: The objective was to compare the efficacy of three different lasers in disinfection of root canals inoculated with Enterococcus faecalis and Candida albicans biofilms. BACKGROUND: Endodontic space disinfection depends on the type of root canal irrigant used and the way it is delivered and agitated because irrigants have limited ability to reach all parts of root canal system. MATERIALS AND METHODS: Thirty single-rooted human teeth were selected...
April 20, 2017: Photomedicine and Laser Surgery
https://www.readbyqxmd.com/read/28424934/synthesis-antioxidant-and-antimicrobial-activities-of-novel-thiopyrano-2-3-d-thiazoles-based-on-aroylacrylic-acids
#9
Andrii Lozynskyi, Viktoria Zasidko, Dmytro Atamanyuk, Danylo Kaminskyy, Halyna Derkach, Olexandr Karpenko, Volodymyr Ogurtsov, Roman Kutsyk, Roman Lesyk
Here it is described the synthesis, antioxidant and antimicrobial activity determination of novel rel-([Formula: see text])-6-benzoyl-7-phenyl-2-oxo-3,5,6,7-tetrahydro-2H-thiopyrano[2,3-d]thiazole-5-carboxylic acids. The target compounds were obtained in good yields from 5-arylidene-4-thioxo-2-thiazolidinones and [Formula: see text]-aroylacrylic acids via regio- and diastereoselective hetero-Diels-Alder reaction. The stereochemistry of the cycloaddition was confirmed by NMR spectra. The antioxidant and antimicrobial activity screening identified 7 compounds (3c, 3e, 3f, 3g, 3k, 3l, 3p) with a high level of free radical scavenging (43-77% DPPH assay), and compounds with significant influence on Staphylococcus aureus, Bacillus subtilis and Candida albicans (MIC 3...
April 19, 2017: Molecular Diversity
https://www.readbyqxmd.com/read/28424737/gc-ms-based-metabolite-profiling-antioxidant-and-antimicrobial-properties-of-different-solvent-extracts-of-malaysian-plectranthus-amboinicus-leaves
#10
Mallappa Kumara Swamy, Greetha Arumugam, Ravinder Kaur, Ali Ghasemzadeh, Mazina Mohd Yusoff, Uma Rani Sinniah
This study evaluates the phytochemistry, antioxidant, and antimicrobial effects of Plectranthus amboinicus leaves extracted in different solvents. The methanol extract contained the highest total phenolic (94.37 ± 1.24 mg GAE/g) and flavonoid contents (26.90 ± 1.35 mg RE/g) and exhibited the highest DPPH scavenging activity (90.13 ± 3.32%) followed by the acetone extract (80.23 ± 3.26%) at 500 μg/mL concentration. Similarly, the highest ferric ion reduction potential (849.63 ± 30.95 μM of Fe (II)/g dry weight) was exhibited by the methanol extract followed by the acetone extract (695...
2017: Evidence-based Complementary and Alternative Medicine: ECAM
https://www.readbyqxmd.com/read/28424663/antimicrobial-photodynamic-therapy-against-endodontic-enterococcus-faecalis-and-candida-albicans-mono-and-mixed-biofilms-in-the-presence-of-photosensitizers-a-comparative-study-with-classical-endodontic-irrigants
#11
Patrícia Diogo, Chantal Fernandes, Francisco Caramelo, Marta Mota, Isabel M Miranda, M A F Faustino, M G P M S Neves, Marciana P Uliana, Kleber T de Oliveira, João M Santos, Teresa Gonçalves
Endodontic biofilms eradication from the infected root canal system remains as the primary focus in endodontic field. In this study, it was assessed the efficacy of antimicrobial Photodynamic Therapy (aPDT) with the Zn(II)chlorin e6 methyl ester (Zn(II)e6Me) activated by red light against monospecies and mixed biofilms of Enterococcus faecalis and Candida albicans. The results were compared with the ones obtained with Rose Bengal (RB), Toluidine Blue-O (TBO), the synthetic tetracationic porphyrin (TMPyP) as well as classical endodontic irrigants (3% NaOCl, 17% EDTA and 2% CHX)...
2017: Frontiers in Microbiology
https://www.readbyqxmd.com/read/28423912/antifungal-activity-of-cinnamic-acid-and-benzoic-acid-esters-against-candida-albicans-strains
#12
Tamires C Lima, Alana R Ferreira, Daniele F Silva, Edeltrudes O Lima, Damião P de Sousa
Candida albicans is an important opportunistic fungal pathogen capable of provoking infection in humans. In the present study, we evaluated the antifungal effect of 23 ester derivatives of the cinnamic and benzoic acids against 3 C. albicans strains (ATCC-76645, LM-106 and LM-23), as well as discuss their Structure-Activity Relationship (SAR). The antifungal assay results revealed that the screened compounds exhibited different levels of activity depending on structural variation. Among the ester analogues, methyl caffeate (5) and methyl 2-nitrocinnamate (10) were the analogues that presented the best antifungal effect against all C...
April 20, 2017: Natural Product Research
https://www.readbyqxmd.com/read/28423089/phenotypic-and-genotypic-detection-of-candida-albicans-and-candida-dubliniensis-strains-isolated-from-oral-mucosa-of-aids-pediatric-patients
#13
Harisson Oliveira Livério, Luciana da Silva Ruiz, Roseli Santos de Freitas, Angela Nishikaku, Ana Clara de Souza, Claudete Rodrigues Paula, Carina Domaneschi
The aim of this study was to assess a collection of yeasts to verify the presence of Candida dubliniensis among strains isolated from the oral mucosa of AIDS pediatric patients which were initially characterized as Candida albicans by the traditional phenotypic method, as well as to evaluate the main phenotypic methods used in the discrimination between the two species and confirm the identification through genotypic techniques, i.e., DNA sequencing. Twenty-nine samples of C. albicans isolated from this population and kept in a fungi collection were evaluated and re-characterized...
April 13, 2017: Revista do Instituto de Medicina Tropical de São Paulo
https://www.readbyqxmd.com/read/28422067/synthesis-characterization-antimicrobial-and-antiproliferative-activity-evaluation-of-cu-ii-co-ii-zn-ii-ni-ii-and-pt-ii-complexes-with-isoniazid-derived-compound
#14
Elena Pahonțu, Diana-Carolina Ilieș, Sergiu Shova, Camelia Oprean, Virgil Păunescu, Octavian Tudorel Olaru, Flavian Ștefan Rădulescu, Aurelian Gulea, Tudor Roșu, Doina Drăgănescu
Hydrazone complexes of Cu(II), Co(II), Zn(II), Ni(II) and Pt(II) with N-isonicotinoyl-N'-(3-metoxy-2 hydroxybenzaldehyde)-hydrazone (HL) were synthesized and characterized by different physico-chemical techniques including elemental and thermal analysis, magnetic susceptibility measurements, molar electric conductivity, as well as IR (infrared), ¹H-NMR and (13)C-NMR (hydrogen and carbon nuclear magnetic resonance, UV-Vis (ultraviolet-visible), FAB (fast atom bombardment), EPR (electron paramagnetic resonance), and mass spectroscopies...
April 19, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/28422057/antifungal-and-anti-biofilm-activities-of-acetone-lichen-extracts-against-candida-albicans
#15
Marion Millot, Marion Girardot, Lucile Dutreix, Lengo Mambu, Christine Imbert
Candida albicans is a commensal coloniser of the human gastrointestinal tract and an opportunistic pathogen, especially thanks to its capacity to form biofilms. This lifestyle is frequently involved in infections and increases the yeast resistance to antimicrobials and immune defenses. In this context, 38 lichen acetone extracts have been prepared and evaluated for their activity against C. albicans planktonic and sessile cells. Minimum inhibitory concentrations of extracts (MICs) were determined using the broth microdilution method...
April 19, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/28421452/susceptibility-of-candida-albicans-from-cystic-fibrosis-patients
#16
Raquel Sabino, Elisabete Carolino, Richard B Moss, Niaz Banaei, Cristina Verissimo, David A Stevens
Candida albicans is a common microbe, colonizer and potential pathogen found in respiratory cultures of cystic fibrosis (CF) patients. Because of possible development of resistance in patient isolates resulting from residence in the abnormal milieu of CF patient airways, or from exposure to antifungals, and considering the possibility of patient-to-patient spread of microbes and reports of elevated resistance to other fungal pathogens, it was important to assay the susceptibility of isolates of Candida and compare that profile to isolates from the community...
April 18, 2017: Mycopathologia
https://www.readbyqxmd.com/read/28421058/antimicrobial-compounds-produced-by-vaginal-lactobacillus-crispatus-are-able-to-strongly-inhibit-candida-albicans-growth-hyphal-formation-and-regulate-virulence-related-gene-expressions
#17
Shuai Wang, Qiangyi Wang, Ence Yang, Ling Yan, Tong Li, Hui Zhuang
The female vaginal environment contains diverse microorganisms, and their interactions play significant roles in health and disease. Lactobacillus species are the predominant vaginal microorganisms in healthy women and relevant as a barrier to defense against pathogens, including Candida albicans. The yeast-to-hyphae transition is believed to be a determinant of C. albicans pathogenesis. In this study, we investigated the effects of vaginal isolates of L. crispatus (seven strains), L. gasseri (six strains), and L...
2017: Frontiers in Microbiology
https://www.readbyqxmd.com/read/28421052/whole-genome-based-amplified-fragment-length-polymorphism-analysis-reveals-genetic-diversity-in-candida-africana
#18
Anuradha Chowdhary, Ferry Hagen, Cheshta Sharma, Abdullah M S Al-Hatmi, Letterio Giuffrè, Domenico Giosa, Shangrong Fan, Hamid Badali, Maria Rosa Felice, Sybren de Hoog, Jacques F Meis, Orazio Romeo
This study aimed at investigating the genetic diversity of a panel of Candida africana strains recovered from vaginal samples in different countries. All fungal strains were heterozygous at the mating-type-like locus and belonged to the genotype A of Candida albicans. Moreover, all examined C. africana strains lack N-acetylglucosamine assimilation and sequence analysis of the HXK1 gene showed a distinctive polymorphism that impair the utilization of this amino sugar in this yeast. Multi-locus sequencing of seven housekeeping genes revealed a substantial genetic homogeneity among the strains, except for the CaMPIb, SYA1 and VPS13 loci which contributed significantly to the classification of our set of C...
2017: Frontiers in Microbiology
https://www.readbyqxmd.com/read/28420830/antimicrobial-and-antibiofilm-activities-of-mta-supplemented-with-bismuth-lipophilic-nanoparticles
#19
Rene Hernandez-Delgadillo, Casiano Del Angel-Mosqueda, Juan Manuel Solís-Soto, Silvia Munguia-Moreno, Nayely Pineda-Aguilar, Rosa Isela Sánchez-Nájera, Shankararaman Chellam, Claudio Cabral-Romero
The objective of this work was to determine the antimicrobial and antibiofilm properties of mineral trioxide aggregate (MTA) supplemented with bismuth lipophilic nanoparticles (BisBAL NPs). The antimicrobial activity of the composite MTA-BisBAL NPs was determined by the disk diffusion assay, while antibiofilm activity was analyzed by fluorescence microscopy. The cytotoxicity of MTA-BisBAL NPs was determined on human gingival fibroblasts by optical microscopy and crystal violet staining. MTA-BisBAL NPs inhibited the growth of Enterococcus faecalis, Escherichia coli, and Candida albicans and also detached the biofilm of fluorescent E...
April 18, 2017: Dental Materials Journal
https://www.readbyqxmd.com/read/28419681/oral-mycobiome-in-community-dwelling-elderly-and-its-relation-to-oral-and-general-health-conditions
#20
Myrna Nurlatifah Zakaria, Michiko Furuta, Toru Takeshita, Yukie Shibata, Rini Sundari, Nobuoki Eshima, Toshiharu Ninomiya, Yoshihisa Yamashita
OBJECTIVE: Oral fungal infection is generally associated with dysbiosis related to antibiotic use, immunodeficiency, or frailty. However, fungal colonization in a typical population without apparent symptoms, and its associated conditions are poorly understood. In this study, oral fungal colonization in community-dwelling and independently living elderly populations was evaluated and factors affecting fungal colonization were analyzed. SUBJECTS AND METHODS: The subjects (410; 181 males and 229 females) were 75-99 years of age; those under prior antibiotic use were excluded...
April 18, 2017: Oral Diseases
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