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Candida albican

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https://www.readbyqxmd.com/read/29668124/a-reduced-dose-of-fluconazole-as-primary-antifungal-prophylaxis-is-not-associated-with-increased-risk-of-invasive-fungal-infections-after-allogeneic-stem-cell-transplantation-from-a-hla-identical-sibling
#1
B Sarina, J Mariotti, S Bramanti, L Morabito, R Crocchiolo, A Rimondo, F Tordato, D Pocaterra, E Casari, Chiara De Philippis, C Carlo-Stella, A Santoro, L Castagna
BACKGROUND: Invasive fungal infections (IFI) represent a common side effect of allogeneic hematopoietic stem cell transplant (allo-SCT), resulting in increased non relapse mortality (NRM) and reduced overall survival (OS) rates. 75-days of Fluconazole 400 mg/day represents the standard primary antifungal prophylaxis (PAP) after allo-SCT, especially for low-risk transplants. However, the ideal dosage of fluconazole has never been tested. METHODS: Here we report the experience of our institution on 113 consecutive patients receiving an allo-SCT from a HLA identical sibling between 1999 and 2015, where PAP consisted of fluconazole 100 mg/day only during the pre-engraftment phase...
April 18, 2018: Transplant Infectious Disease: An Official Journal of the Transplantation Society
https://www.readbyqxmd.com/read/29667487/pre-colonization-with-the-commensal-fungus-candida-albicans-reduces-murine-susceptibility-to-clostridium-difficile-infection
#2
Laura Markey, Lamyaa Shaban, Erin R Green, Katherine P Lemon, Joan Mecsas, Carol A Kumamoto
Clostridium difficile is a major nosocomial pathogen responsible for close to half a million infections and 27,000 deaths annually in the U.S. Preceding antibiotic treatment is a major risk factor for C. difficile infection (CDI) leading to recognition that commensal microbes play a key role in resistance to CDI. Current antibiotic treatment of CDI is only partially successful due to a high rate of relapse. As a result, there is interest in understanding the effects of microbes on CDI susceptibility to support treatment of patients with probiotic microbes or entire microbial communities (e...
April 18, 2018: Gut Microbes
https://www.readbyqxmd.com/read/29667274/impact-of-farnesol-and-corsodyl-%C3%A2-on-candida-albicans-forming-dual-biofilm-with-streptococcus-mutans
#3
Lucia Černáková, Luisa Jordao, Helena Bujdáková
OBJECTIVE: This work studied the biofilm formed by Candida albicans and Streptococcus mutans on a hydroxyapatite surface after exposure to the quorum-sensing molecule farnesol (200 μM) in comparison with the diluted mouthwash Corsodyl® (0.0001% chlorhexidine digluconate). MATERIALS AND METHODS: The cytotoxicity of farnesol was evaluated by Galleria melonella surviving assay. The viability of biofilm cells after exposure to farnesol and Corsodyl® was determined by colony-forming units...
April 18, 2018: Oral Diseases
https://www.readbyqxmd.com/read/29666708/nonphotodynamic-roles-of-methylene-blue-display-of-distinct-antimycobacterial-and-anticandidal-mode-of-actions
#4
Rahul Pal, Moiz A Ansari, Venkata Saibabu, Shrayanee Das, Zeeshan Fatima, Saif Hameed
Significance of methylene blue (MB) in photodynamic therapy against microbes is well established. Previously, we have reported the antifungal potential of MB against Candida albicans . The present study attempts to identify additional antimicrobial effect of MB against another prevalent human pathogen, Mycobacterium tuberculosis (MTB). We explored that MB is efficiently inhibiting the growth of Mycobacterium at 15.62  μ g/ml albeit in bacteriostatic manner similar to its fungistatic nature. We uncovered additional cell surface phenotypes (colony morphology and cell sedimentation rate) which were impaired only in Mycobacterium ...
2018: Journal of Pathogens
https://www.readbyqxmd.com/read/29666621/the-role-of-aire-in-the-immunity-against-candida-albicans-in-a-model-of-human-macrophages
#5
Jose Antonio Tavares de Albuquerque, Pinaki Prosad Banerjee, Angela Castoldi, Royce Ma, Nuria Bengala Zurro, Leandro Hideki Ynoue, Christina Arslanian, Marina Uchoa Wall Barbosa-Carvalho, Joya Emilie de Menezes Correia-Deur, Fernanda Guimarães Weiler, Magnus Regios Dias-da-Silva, Marise Lazaretti-Castro, Luis Alberto Pedroza, Niels Olsen Saraiva Câmara, Emily Mace, Jordan Scott Orange, Antonio Condino-Neto
Autoimmune-polyendocrinopathy-candidiasis-ectodermal dystrophy (APECED) is a primary immunodeficiency caused by mutations in the autoimmune regulator gene ( AIRE ). Patients with AIRE mutations are susceptible to Candida albicans infection and present with autoimmune disorders. We previously demonstrated that cytoplasmic AIRE regulates the Syk-dependent Dectin-1 pathway. In this study, we further evaluated direct contact with fungal elements, synapse formation, and the response of macrophage-like THP-1 cells to C...
2018: Frontiers in Immunology
https://www.readbyqxmd.com/read/29666281/pathogenic-effects-of-ifit2-and-interferon-%C3%AE-during-fatal-systemic-candida-albicans-infection
#6
Marcin Stawowczyk, Shamoon Naseem, Valeria Montoya, Darren P Baker, James Konopka, Nancy C Reich
A balanced immune response to infection is essential to prevent the pathology and tissue damage that can occur from an unregulated or hyperactive host defense. Interferons (IFNs) are critical mediators of the innate defense to infection, and in this study we evaluated the contribution of a specific gene coding for IFIT2 induced by type I IFNs in a murine model of disseminated Candida albicans Invasive candidiasis is a frequent challenge during immunosuppression or surgical medical interventions, and C. albicans is a common culprit that leads to high rates of mortality...
April 17, 2018: MBio
https://www.readbyqxmd.com/read/29665954/candida-species-in-tchapalo-and-bangui-two-traditional-alcoholic-beverages-from-c%C3%A3-te-d-ivoire
#7
Laurence A N Egue, Florent K N'guessan, Solange Aka-Gbezo, Jean-Paul K M Bouatenin, Marina Koussemon-Camara
The increase of infections due to non-Candida albicans species made it very necessary to conduct adequate characterization to be able to identify the species of Candida isolated from traditional fermented foods. In this study, based on their hue on Candida Chromogenic Agar medium, a total of 136 yeast strains were isolated from tchapalo and bangui. Molecular identification based on PCR-RFLP of internal transcribed spacers of rDNA (ITS) and sequencing of the ITS and the D1/D2 regions allowed us to assign these isolates to seven species: Candida tropicalis, Candida inconspicua, Candida rugosa, Saccharomyces cerevisiae, Kluyveromyces marxianus, Hanseniaspora guilliermondii, Trichosporon asahii...
May 2018: Fungal Biology
https://www.readbyqxmd.com/read/29665644/biodistribution-of-free-and-encapsulated-99m-tc-fluconazole-in-an-infection-model-induced-by-candida-albicans
#8
Danielle Nogueira de Assis, Raquel Silva Araújo, Leonardo Lima Fuscaldi, Simone Odília Antunes Fernandes, Vanessa Carla Furtado Mosqueira, Valbert Nascimento Cardoso
BACKGROUND: Candida spp is an etiologic agent of fungal infections in hospitals and resistance to treatment with antifungals has been extensively reported. Thus, it is very important to develop formulations that increase effectiveness with low toxicity. In this sense, nanocarriers have been investigated, once they modify drug biodistribution profile. Thus, this study aimed to evaluate the biodistribution of free and encapsulated 99m Tc-fluconazole into nanocapsules (NCs) in an experimental immunosuppressed murine model of Candida albicans infection...
March 2018: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/29665368/streptomyces-thermoviolaceus-src3-strain-as-a-novel-source-of-the-antibiotic-adjuvant-streptazolin-a-statistical-approach-toward-the-optimized-production
#9
Ibtissem Djinni, Warda Djoudi, Samiha Souagui, Farida Rabia, Sihem Rahmouni, Ines Mancini, Mouloud Kecha
Streptomyces thermoviolaceus SRC3, a newly isolated actinobacterial strain from Algerian river sediments, exhibited a broad activity against various bacterial and yeast human pathogens (Salmonella typhi ATCC 14028, Vibrio cholerae ATCC 14035, MRSA ATCC 43300 and Candida albicans ATCC 10231). The strain SRC3 was selected from thirty nine actinobacterial isolates and identified as S. thermoviolaceus based on morphology, cultural properties, physiological analyses and 16S rRNA gene sequencing. Culture parameters for the antibiotic production were optimized by sequential statistical strategy including Plackett-Burman design (PBD) and Response Surface Methodology (RSM)...
April 14, 2018: Journal of Microbiological Methods
https://www.readbyqxmd.com/read/29663565/risk-factors-for-early-invasive-fungal-infections-in-pediatric-liver-transplant-recipients
#10
Yehonatan Pasternak, Shiri Rubin, Efraim Bilavsky, Yael Mozer-Glassberg, Itzhak Levy, Elhanan Nahum, Eran Rom, Michael Gurevich, Haim Ben-Zvi, Liat Ashkenazi-Hoffnung
BACKGROUND: Invasive fungal infections (IFIs) post-liver transplantation are a frequent cause of morbidity and mortality;however, studies reporting on these infections in the pediatric population are scarce. OBJECTIVE: To investigate the incidence and risk factors of IFIs in pediatric liver transplant recipients during the early post-transplantation period (≤3 months). MATERIALS AND METHODS: Data were collected for all pediatric liver transplant recipients registered in a national transplantation center from 2004-2014...
April 17, 2018: Mycoses
https://www.readbyqxmd.com/read/29661910/myeloid-cell-deficiency-of-p38%C3%AE-p38%C3%AE-protects-against-candidiasis-and-regulates-antifungal-immunity
#11
Dayanira Alsina-Beauchamp, Alejandra Escós, Pilar Fajardo, Diego González-Romero, Ester Díaz-Mora, Ana Risco, Miguel A Martín-Serrano, Carlos Del Fresno, Jorge Dominguez-Andrés, Noelia Aparicio, Rafal Zur, Natalia Shpiro, Gordon D Brown, Carlos Ardavín, Mihai G Netea, Susana Alemany, Juan J Sanz-Ezquerro, Ana Cuenda
Candida albicans is a frequent aetiologic agent of sepsis associated with high mortality in immunocompromised patients. Developing new antifungal therapies is a medical need due to the low efficiency and resistance to current antifungal drugs. Here, we show that p38γ and p38δ regulate the innate immune response to C. albicans We describe a new TAK1-TPL2-MKK1-ERK1/2 pathway in macrophages, which is activated by Dectin-1 engagement and positively regulated by p38γ/p38δ. In mice, p38γ/p38δ deficiency protects against C...
April 16, 2018: EMBO Molecular Medicine
https://www.readbyqxmd.com/read/29661876/antimicrobial-and-antibiofilm-efficacy-of-graphene-oxide-against-chronic-wound-microorganisms
#12
Mara Di Giulio, Romina Zappacosta, Silvia Di Lodovico, Emanuela Di Campli, Gabriella Siani, Antonella Fontana, Luigina Cellini
Chronic wounds represent an increasing problem worldwide. Graphene oxide (GO) has been reported to exhibit strong antibacterial activity towards both Gram-positive and Gram-negative bacteria. The aim of this work was to investigate the in vitro antimicrobial and antibiofilm efficacy of GO against wound pathogens. Staphylococcus aureus PECHA 10, Pseudomonas aeruginosa PECHA 4 and Candida albicans X3 clinical isolates were incubated with 50 mg/L of GO for 2 and 24 h to evaluate the antimicrobial effect. Optical and Atomic force microscopy images were performed to visualize the GO effect on microbial cells...
April 16, 2018: Antimicrobial Agents and Chemotherapy
https://www.readbyqxmd.com/read/29661606/potential-effect-of-2-isopropyl-5-methylphenol-thymol-alone-and-in-combination-with-fluconazole-against-clinical-isolates-of-candida-albicans-c-glabrata-and-c-krusei
#13
A Sharifzadeh, A R Khosravi, H Shokri, H Shirzadi
Limitations of antifungals used in the treatment of candidiasis, as the development of resistant strains, are known by the scientific community. In this context, the aim of this study was to investigate the activity of 2-isopropyl-5-methylphenol (thymol) in combination with fluconazole (FLZ) against clinical Candida strains. The antifungal activity of thymol along with FLZ was evaluated by the Clinical Laboratory Standards Institute (CLSI) M27-A2 broth microdilution method. In addition, synergism was observed for clinical strains of Candida spp...
April 14, 2018: Journal de Mycologie Médicale
https://www.readbyqxmd.com/read/29661553/development-of-a-contaminated-ischemic-porcine-wound-model-and-the-evaluation-of-bromelain-based-enzymatic-debridement
#14
Adam J Singer, Jimmy Toussaint, Won Taek Chung, Steve A McClain, Richard A F Clark, Eilon Asculai, Dafna Geblinger, Lior Rosenberg
OBJECTIVES: There are no well accepted animal models of chronic wounds, limiting advances in understanding and treatment of chronic ulcers. We developed a porcine wound model which combines multiple factors involved in chronic wounds to create a contaminated necrotic eschar and evaluated the debriding efficacy of a novel bromelain based enzymatic debriding agent (EscharEx). METHODS: Contaminated ischemic wounds were created on the flanks of domestic pigs by 'sandwiching' the skin between 2 'O' rings (1 placed on the surface of the skin and the other underneath the skin) for 24h prior to dermatomal excision of the necrotic eschar and its contamination with Staphylococcus aureus and Candida albicans...
April 13, 2018: Burns: Journal of the International Society for Burn Injuries
https://www.readbyqxmd.com/read/29658789/effect-of-2-phenylethanol-as-antifungal-agent-and-common-antifungals-amphotericin-b-fluconazole-and-itraconazole-on-candida-species-isolated-from-chronic-and-recurrent-cases-of-candidal-vulvovaginitis
#15
Niloufar Majdabadi, Mehraban Falahati, Fariba Heidarie-Kohan, Shirin Farahyar, Parvaneh Rahimi-Moghaddam, Mahtab Ashrafi-Khozani, Tandis Razavi, Sina Mohammadnejad
The antifungal effects of 2-phenylethanol are clearly visible through its intervention in Candida morphogenesis. Chronic and recurrent vulvovaginitis, however, does not respond to this standard experimental therapy; therefore, the study presented in this article investigated the effect of common antifungal drugs (amphotericin B [AMB], fluconazole [FLU], and itraconazole [ITC]), in combination with 2-phenylethanol, on the Candida species isolated from cases of chronic and recurrent vulvovaginitis, thereby allowing the recommendation of a more appropriate treatment option...
April 2018: Assay and Drug Development Technologies
https://www.readbyqxmd.com/read/29657786/amphotericin-b-conjugated-polypeptide-hydrogels-as-a-novel-innovative-strategy-for-fungal-infections
#16
Chang Shu, Tengfei Li, Wen Yang, Duo Li, Shunli Ji, Li Ding
The present work is focused on the design and development of novel amphotericin B (AmB)-conjugated biocompatible and biodegradable polypeptide hydrogels to improve the antifungal activity. Using three kinds of promoting self-assembly groups (2-naphthalene acetic acid (Nap), naproxen (Npx) and dexamethasone (Dex)) and polypeptide sequence (Phe-Phe-Asp-Lys-Tyr, FFDKY), we successfully synthesized the Nap-FFDK(AmB)Y gels, Npx-FFDK(AmB)Y gels and Dex-FFDK(AmB)Y gels. The AmB-conjugated hydrogelators are highly soluble in different aqueous solutions...
March 2018: Royal Society Open Science
https://www.readbyqxmd.com/read/29657531/antimicrobial-efficacy-of-2-5-sodium-hypochlorite-2-chlorhexidine-and-ozonated-water-as-irrigants-in-mesiobuccal-root-canals-with-severe-curvature-of-mandibular-molars
#17
Sergio Luiz Pinheiro, Caio Cesar da Silva, Lucas Augusto da Silva, Marina P Cicotti, Carlos Eduardo da Silveira Bueno, Carlos Eduardo Fontana, Letícia R Pagrion, Natália P Dalmora, Thaís T Daque, Francisco Uf de Campos
Objective: The aim of this study is to evaluate the antimicrobial efficacy of 2.5% sodium hypochlorite, 2% chlorhexidine, and ozonated water on biofilms of Enterococcus faecalis , Streptococcus mutans , and Candida albicans in mesiobuccal root canals with severe curvature of mandibular molars. Materials and Methods: This was an experimental ex vivo study in microbiologic laboratory. Sixty mesiobuccal root canals with severe curvature of mandibular molars were contaminated with standard strains of E...
January 2018: European Journal of Dentistry
https://www.readbyqxmd.com/read/29657503/phytochemical-constituents-and-antimicrobial-activity-of-the-ethanol-and-chloroform-crude-leaf-extracts-of-spathiphyllum-cannifolium-dryand-ex-sims-schott
#18
Arunachalam Dhayalan, Daniel E Gracilla, Renato A Dela Peña, Marilyn T Malison, Christian R Pangilinan
Context: The study investigated the medicinal properties of Spathiphyllum cannifolium (Dryand. ex Sims) Schott as a possible source of antimicrobial compounds. Materials and Methods: The phytochemical constituents were screened using qualitative methods and the antibacterial and antifungal activities were determined using agar well diffusion method. Statistical Analysis: One-way analysis of variance and Fisher's least significant difference test were used...
January 2018: Journal of Pharmacy & Bioallied Sciences
https://www.readbyqxmd.com/read/29656672/screening-of-in-vitro-antimicrobial-activity-of-plants-used-in-traditional-indonesian-medicine
#19
Andreas Romulo, Ervizal A M Zuhud, Johana Rondevaldova, Ladislav Kokoska
CONTEXT: In many regions of Indonesia, there are numerous traditional herbal preparations for treatment of infectious diseases. However, their antimicrobial potential has been poorly studied by modern laboratory methods. OBJECTIVE: This study investigates in vitro antimicrobial activity of 49 ethanol extracts from 37 plant species used in Indonesian traditional medicine for treatment against Candida albicans, Enterococcus faecalis, Escherichia coli, Pseudomonas aeruginosa and Staphylococcus aureus...
December 2018: Pharmaceutical Biology
https://www.readbyqxmd.com/read/29656577/efficacy-of-7-benzyloxyindole-and-other-halogenated-indoles-to-inhibit-candida-albicans-biofilm-and-hyphal-formation
#20
Ranjith Kumar Manoharan, Jin-Hyung Lee, Jintae Lee
Certain pathogenic bacteria and yeast form biofilms on biotic and abiotic surfaces including medical devices and implants. Hence, the development of antibiofilm coating materials becomes relevant. The virulence of those colonizing pathogens can be reduced by inhibiting biofilm formation rather than killing pathogens using excessive amounts of antimicrobials, which is touted as one of the main reasons for the development of drug resistance. Candida albicans is an opportunistic fungal pathogen, and the transition of yeast cells to hyphal cells is believed to be a crucial virulence factor...
April 15, 2018: Microbial Biotechnology
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