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https://www.readbyqxmd.com/read/28813144/stimulated-raman-imaging-reveals-aberrant-lipogenesis-as-a-meta-bolic-marker-for-azole-resistant-candida-albicans
#1
Caroline W Karanja, Weili Hong, Waleed Younis, Hassan E Eldesouky, Mohamed N Seleem, Ji-Xin Cheng
Candida albicans (C. albicans) is the single most prevalent cause of fungal bloodstream infections worldwide causing significant mortality as high as fifty percent. This high mortality rate is, in part, due to the inability to initiate an effective antifungal therapy early in the disease process. Mortality rates significantly increase after twelve hours of delay in initiating the appropriate antifungal therapy following a positive blood culture. Early administration of appropriate antifungal therapy is hampered by the slow turnovers of the conventional antimicrobial testing techniques, which require days of incubation...
August 16, 2017: Analytical Chemistry
https://www.readbyqxmd.com/read/28812018/effects-of-fungicides-on-rat-s-neurosteroid-synthetic-enzymes
#2
Xiuwei Shen, Fan Chen, Lanlan Chen, Ying Su, Ping Huang, Ren-Shan Ge
Exposure to environmental endocrine disruptors may interfere with nervous system's activity. Fungicides such as tebuconazole, triadimefon, and vinclozolin have antifungal activities and are used to prevent fungal infections in agricultural plants. In the present study, we studied effects of tebuconazole, triadimefon, and vinclozolin on rat's neurosteroidogenic 5α-reductase 1 (5α-Red1), 3α-hydroxysteroid dehydrogenase (3α-HSD), and retinol dehydrogenase 2 (RDH2). Rat's 5α-Red1, 3α-HSD, and RDH2 were cloned and expressed in COS-1 cells, and effects of these fungicides on them were measured...
2017: BioMed Research International
https://www.readbyqxmd.com/read/28811751/bioactive-potential-of-3d-printed-oleo-gum-resin-disks-b-papyrifera-c-myrrha-and-s-benzoin-loading-nanooxides-tio2-p25-cu2o-and-moo3
#3
Diogo José Horst, Sergio Mazurek Tebcherani, Evaldo Toniolo Kubaski, Rogério de Almeida Vieira
This experimental study investigates the bioactive potential of filaments produced via hot melt extrusion (HME) and intended for fused deposition modeling (FDM) 3D printing purposes. The oleo-gum-resins from benzoin, myrrha, and olibanum in pure state and also charged with 10% of metal oxide nanoparticles, TiO2, P25, Cu2O, and MoO3, were characterized by ultraviolet-visible (UV-Vis) and Fourier transform infrared (FTIR) spectroscopy, energy-dispersive X-ray microanalysis (EDXMA), scanning electron microscopy (SEM), and differential scanning calorimetry (DSC)...
2017: Bioinorganic Chemistry and Applications
https://www.readbyqxmd.com/read/28811611/the-antibacterial-and-antifungal-activity-of-six-essential-oils-and-their-cyto-genotoxicity-to-human-hel-12469-cells
#4
Andrea Puškárová, Mária Bučková, Lucia Kraková, Domenico Pangallo, Katarína Kozics
Six essential oils (from oregano, thyme, clove, lavender, clary sage, and arborvitae) exhibited different antibacterial and antifungal properties. Antimicrobial activity was shown against pathogenic (Escherichia coli, Salmonella typhimurium, Yersinia enterocolitica, Staphylococcus aureus, Listeria monocytogenes, and Enterococcus faecalis) and environmental bacteria (Bacillus cereus, Arthrobacter protophormiae, Pseudomonas fragi) and fungi (Chaetomium globosum, Penicillium chrysogenum, Cladosporium cladosporoides, Alternaria alternata, and Aspergillus fumigatus)...
August 15, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28811531/the-selective-antifungal-activity-of-drosophila-melanogaster-metchnikowin-reflects-the-species-dependent-inhibition-of-succinate-coenzyme-q-reductase
#5
Mohammad-Reza Bolouri Moghaddam, Thomas Gross, Annette Becker, Andreas Vilcinskas, Mohammad Rahnamaeian
Insect-derived antifungal peptides have a significant economic potential, particularly for the engineering of pathogen-resistant crops. However, the nonspecific antifungal activity of such peptides could result in detrimental effects against beneficial fungi, whose interactions with plants promote growth or increase resistance against biotic and abiotic stress. The antifungal peptide metchnikowin (Mtk) from Drosophila melanogaster acts selectively against pathogenic Ascomycota, including Fusarium graminearum, without affecting Basidiomycota such as the beneficial symbiont Piriformospora indica...
August 15, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28811086/proteomic-profiling-of-the-antifungal-drug-response-of-aspergillus-fumigatus-to-voriconazole
#6
Nansalmaa Amarsaikhan, Daniela Albrecht-Eckardt, Christoph Sasse, Gerhard H Braus, Zumrut B Ogel, Olaf Kniemeyer
Antifungal resistance is an emerging problem and one of the reasons for treatment failure of invasive aspergillosis (IA). Voriconazole has become a standard therapeutic for the treatment of this often fatal infection. We studied the differentially expressed proteins as a response of Aspergillus fumigatus to voriconazole by employing the two-dimensional difference gel electrophoresis (DIGE) technique. Due to addition of drug, a total of 135 differentially synthesized proteins were identified by MALDI-TOF/TOF-mass spectrometry...
August 5, 2017: International Journal of Medical Microbiology: IJMM
https://www.readbyqxmd.com/read/28811000/a-case-of-cutaneous-leishmaniasis-guyanensis-mimicking-otitis-externa
#7
Eric S Goodrich, Stephen C Sears, Timothy Sorrells, James K Radike, Anis Miladi, Jonathan S Glass
Cutaneous leishmaniasis typically presents as a painless papule progressing to an ulcer or plaque. In this case study of the ear, the disease manifested as a small painful bump progressing into redness and swelling about the ear with purulent drainage. After multiple oral/intravenous antipseudomonal, antistaphylococcal, and antifungal treatments, there was no improvement. The skin progressed to an erythematous plaque and hemorrhagic ulcer; punch biopsy and speciation revealed Leishmaniasis guyanensis. The patient was switched to a seven-dose course of intravenous L-amphotericin B (visceral leishmaniasis protocol)...
July 2017: Military Medicine
https://www.readbyqxmd.com/read/28810606/aspergillus-niger-bloodstream-infection-in-gastric-cancer-after-common-hepatic-artery-embolization-a-case-report
#8
Li Lin, Chuan-Hua Zhao, Xiu-Yun Yin, Yu-Ling Chen, Hong-Yan Zhai, Chun-Wei Xu, Yan Wang, Fei-Jiao Ge, Jian-Ming Xu
The present case study reported on a 62-year-old male patient with gastric cancer-associated Aspergillus (A.) niger bloodstream infection. The patient presented with massive hemorrhage in the gastrointestinal tract 3 months after total gastrectomy for gastric cancer. Conservative treatment consisting of blood transfusion to supplement blood volume loss was ineffective. Digital subtraction angiography indicated gastroduodenal artery bleeding. The first attempt of performing arterial embolization using gelatin sponges failed, while the second attempt of performing common hepatic artery embolization using gelatin sponges and micro-coil springs stopped the bleeding...
August 2017: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/28810046/aspergillus-endophthalmitis-resulting-in-development-of-retinal-aspergilloma
#9
Lee Kiang, Ashkan Pirouz, Scott Grant, Sean D Adrean, Mehrdad Malihi, Phoebe Lin
A 78-year-old immunocompetent man presented with a 3-month history of painless decreased vision and panuveitis with a macular lesion presumed to be due to endogenous endophthalmitis. He had been treated with systemic, intravenous, and intravitreal antibiotics and antifungal agents as well as intravitreal steroids. A culture from a prior vitrectomy had grown a single colony of Aspergillus thought to be a contaminant. The macular lesion enlarged and caused a tractional retinal detachment. The patient underwent surgery including resection of what appeared to be an invasive retinal aspergilloma, from which polymerase chain reaction and histopathology confirmed Aspergillus fumigatus...
August 1, 2017: Ophthalmic Surgery, Lasers & Imaging Retina
https://www.readbyqxmd.com/read/28809644/-endoprosthesis-infections-guidelines-for-antibiotic-therapy-common-guidelines-of-the-czech-society-for-orthopaedics-and-traumatology-and-the-society-for-infectious-diseases-of-the-czech-medical-association-of-j-e-purkyn%C3%A4
#10
D Musil, M Balejová, M Horníková, A Chrdle, N Mallátová, O Nyč, V Chmelík, J Gallo, D Jahoda, J Stehlík
PURPOSE OF THE STUDY This study aims to articulate regional guidelines for curative and suppressive antibiotic therapy of total joint replacement infections. MATERIAL AND METHODS When developing the standard, used as source materials were the published foreign guidelines for antibiotic therapy of prosthetic joint infections, the analysis of resistance of bacterial strains conducted in the Hospital in České Budějovice, a.s. and the assessment of strain resistance for the Czech Republic published by the European Antimicrobial Resistance Surveillance Network (EARS-Net)...
2017: Acta Chirurgiae Orthopaedicae et Traumatologiae Cechoslovaca
https://www.readbyqxmd.com/read/28809155/microbe-profile-candida-albicans-a-shape-changing-opportunistic-pathogenic-fungus-of-humans
#11
Neil A R Gow, Bhawna Yadav
(a) Morphotypes of Candida albicans (blue sector, vegetative forms; pink sector, forms related to mating or changes in ploidy). Cell types shown include: budding yeast cells; elongated conjoined yeasts forming pseudohyphae; parallel-sided hyphae; chlamydospores formed from suspensor cells; enlarged goliath cells formed under zinc deprivation (unpublished study, image from Duncan Wilson); intestinal gut form cells (image from Suzanne Noble); mating competence defined by white-grey-opaque cell transitions (images from Guanghua Huang); elongated chemotactic shmoo-mating projections leading to tetraploid zygote formation (images from David Soll and Karla Daniels); trimera formed by unequal chromosome segregation under antifungal exposure (image from Judith Berman)...
August 15, 2017: Microbiology
https://www.readbyqxmd.com/read/28809119/diastereoselective-intramolecular-heck-reaction-assisted-by-an-acetate-group-synthesis-of-the-decahydrobenzofluorene-derivative-dasyscyphin-e
#12
Fermín Jiménez, Antonio Fernández, Ettahir Boulifa, Ahmed Ibn Mansour, Ramon Alvarez-Manzaneda, Rachid Chahboun, Enrique Alvarez-Manzaneda
The first synthesis of antifungal sesquiterpene quinol dasyscyphin E has been achieved starting from trans-communic acid. The process described involves the first diastereoselective synthesis of this type of compound by cyclization of an aryl bicyclosesquiterpene. The acid was efficiently transformed into a sesquiterpene synthon, which was converted into the corresponding bromoaryl sesquiterpene. The key step of synthetic sequence was the cyclisation of the latter under Heck reaction conditions, which yielded the tetracyclic skeleton of the target compound with complete diastereoselectivity...
August 15, 2017: Journal of Organic Chemistry
https://www.readbyqxmd.com/read/28808616/periprosthetic-hip-joint-infection-with-aspergillus-terreus-a-clinical-case-and-a-review-of-the-literature
#13
Rachel Bartash, Yi Guo, John B Pope, Michael H Levi, Wendy Szymczak, Nidhi Saraiya, Priya Nori
Fungal periprosthetic joint infections due to Aspergillus species are rare but are associated with significant cost and morbidity. We present a case of Asperigillus terreus prosthetic joint infection of the hip. The patient was successfully treated with a prolonged course of systemic antifungals along with surgical management.
December 2017: Medical Mycology Case Reports
https://www.readbyqxmd.com/read/28808367/isolated-renal-mucormycosis-in-immunocompetent-children-a-report-of-two-cases
#14
Sai Saran, Kirti Naranje, Mohan Gurjar, Dharmendra Bhadauria, Anupama Kaul, Banani Poddar
Isolated renal mucormycosis is a rare entity in children. It is potentially fatal when not detected and managed early with antifungal therapy, and surgery as and when needed. We present two immunocompetent children who developed this infection and subsequently succumbed to it. The diagnosis was established postmortem on renal biopsy specimens. We also discuss the 9 cases of isolated renal involvement in children published in literature.
July 2017: Indian Journal of Critical Care Medicine
https://www.readbyqxmd.com/read/28807835/the-role-of-antimicrobial-stewardship-programmes-in-children-a-systematic-review
#15
REVIEW
André Ricardo Araujo da Silva, Déborah Cardoso Albernaz de Almeida Dias, Amanda Fáris Marques, Clara Biscaia di Biase, Indah K Murni, Angela Dramowski, Mike Sharland, Johanes Huebner, Walter Zingg
The United Nations and the World Health Organization have designated antimicrobial resistance (AMR) as a major health priority and developed action plans to reduce AMR in all healthcare settings. Establishment of institutional antimicrobial stewardship programmes (ASPs) is advocated as a key intervention to reduce antibiotic consumption in hospitals and address high rates of multi-drug resistant (MDR) bacteria. We searched PUBMED and the Cochrane database of systematic reviews (1/2007-3/2017) to identify studies reporting about the effectiveness of ASPs in general paediatric wards and paediatric intensive care units (PICU), on reducing antibiotic consumption, on using broad spectrum/restricted antibiotics, and on antibiotic resistance and healthcare-associated infections (HAIs)...
August 11, 2017: Journal of Hospital Infection
https://www.readbyqxmd.com/read/28806704/chiral-pharmaceuticals-a-review-on-their-environmental-occurrence-and-fate-processes
#16
REVIEW
Edmond Sanganyado, Zhijiang Lu, Qiuguo Fu, Daniel Schlenk, Jay Gan
More than 50% of pharmaceuticals in current use are chiral compounds. Enantiomers of the same pharmaceutical have identical physicochemical properties, but may exhibit differences in pharmacokinetics, pharmacodynamics and toxicity. The advancement in separation and detection methods has made it possible to analyze trace amounts of chiral compounds in environmental media. As a result, interest on chiral analysis and evaluation of stereoselectivity in environmental occurrence, phase distribution and degradation of chiral pharmaceuticals has grown substantially in recent years...
August 5, 2017: Water Research
https://www.readbyqxmd.com/read/28806568/a-simple-high-performance-liquid-chromatography-mass-spectrometry-method-for-therapeutic-drug-monitoring-of-isavuconazole-and-four-other-antifungal-drugs-in-human-plasma-samples
#17
Giovanna Fatiguso, Fabio Favata, Ilaria Zedda, Amedeo De Nicolò, Jessica Cusato, Valeria Avataneo, Giovanni Di Perri, Antonio D'Avolio
Triazoles chanced the prevention and treatment of invasive fungal infections, but their pharmacokinetic properties are still unclear. In particular, isavuconazole (ISC) is a new broad-spectrum antifungal triazole approved in 2015 as first-line treatment for intravenous and oral use against invasive aspergillosis and for mucormycosis. Nowadays, the optimal management of the treatments with triazoles requires the use of Therapeutic Drug Monitoring (TDM), in order to prevent sub-therapeutic or toxic concentrations...
August 5, 2017: Journal of Pharmaceutical and Biomedical Analysis
https://www.readbyqxmd.com/read/28805964/therapeutic-drug-monitoring-of-voriconazole-for-treatment-and-prophylaxis-of-invasive-fungal-infection-in-children
#18
Sarah Allegra, Giovanna Fatiguso, Silvia De Francia, Fabio Favata, Elisa Pirro, Chiara Carcieri, Amedeo De Nicolò, Jessica Cusato, Giovanni Di Perri, Antonio D'Avolio
Voriconazole therapeutic drug monitoring is not consistently recommended due to its high interpatients and intrapatients variability. Here, we aimed to describe our experience with voriconazole for treatment and prophylaxis of invasive fungal infections, in paediatric patients. A fully validated HPLC-MS method was used to quantify voriconazole concentration in plasma, at the end of dosing interval. A high interindividual variability was shown. We enrolled 237 children, 83 receiving intravenous and 154 oral voriconazole...
August 14, 2017: British Journal of Clinical Pharmacology
https://www.readbyqxmd.com/read/28805743/inhibitors-of-the-detoxifying-enzyme-of-the-phytoalexin-brassinin-based-on-quinoline-and-isoquinoline-scaffolds
#19
M Soledade C Pedras, Abbas Abdoli, Vijay K Sarma-Mamillapalle
The detoxification of the phytoalexin brassinin to indole-3-carboxaldehyde and S-methyl dithiocarbamate is catalyzed by brassinin oxidase (BOLm), an inducible fungal enzyme produced by the plant pathogen Leptosphaeria maculans. Twenty-six substituted quinolines and isoquinolines are synthesized and evaluated for antifungal activity against L. maculans and inhibition of BOLm. Eleven compounds that inhibit BOLm activity are reported, of which 3-ethyl-6-phenylquinoline displays the highest inhibitory effect. In general, substituted 3-phenylquinolines show significantly higher inhibitory activities than the corresponding 2-phenylquinolines...
August 14, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/28805711/a-dereplication-and-bioguided-discovery-approach-to-reveal-new-compounds-from-a-marine-derived-fungus-stilbella-fimetaria
#20
Sara Kildgaard, Karolina Subko, Emma Phillips, Violaine Goidts, Mercedes de la Cruz, Caridad Díaz, Charlotte H Gotfredsen, Birgitte Andersen, Jens C Frisvad, Kristian F Nielsen, Thomas O Larsen
A marine-derived Stilbella fimetaria fungal strain was screened for new bioactive compounds based on two different approaches: (i) bio-guided approach using cytotoxicity and antimicrobial bioassays; and (ii) dereplication based approach using liquid chromatography with both diode array detection and high resolution mass spectrometry. This led to the discovery of several bioactive compound families with different biosynthetic origins, including pimarane-type diterpenoids and hybrid polyketide-non ribosomal peptide derived compounds...
August 13, 2017: Marine Drugs
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