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https://www.readbyqxmd.com/read/29228380/elderly-versus-nonelderly-patients-with-invasive-aspergillosis-in-the-icu-a-comparison-and-risk-factor-analysis-for-mortality-from-the-aspicu-cohort
#1
D K Matthaiou, G Dimopoulos, F S Taccone, P Bulpa, A M Van den Abeele, B Misset, W Meersseman, H Spapen, T Cardoso, P E Charles, D Vogelaers, S Blot
Data regarding the epidemiology and diagnosis of invasive aspergillosis in the critically ill population are limited, with data regarding elderly patients (≥75 years old) even scarcer. We aimed to further compare the epidemiology, characteristics and outcome of elderly versus nonelderly critically ill patients with invasive aspergillosis (IA) Prospective, international, multicenter observational study (AspICU) including adult intensive care unit (ICU) patients, with a culture and/or direct examination and/or histopathological sample positive for Aspergillus spp...
December 8, 2017: Medical Mycology: Official Publication of the International Society for Human and Animal Mycology
https://www.readbyqxmd.com/read/29228372/a-novel-tomographic-imaging-probe-for-rapid-diagnosis-of-fungal-keratitis
#2
Min Hee Lee, Gregory Wiedman, Steven Park, Arkady Mustaev, Yanan Zhao, David S Perlin
Fungal keratitis is a leading cause of ocular morbidity and blindness in developing countries. Diagnosing fungal keratitis currently relies on a comparative evaluation of corneal biopsy or scraping using a direct microscopy and culture results. These methods not only carry the risk of developing complications due to the invasive tissue sampling but also are largely limited by diagnostic speed and accuracy, making it difficult to initiate timely appropriate antifungal therapy. Therefore, rapid and noninvasive diagnostic tools are a pressing need for improved outcomes for fungal keratitis...
December 8, 2017: Medical Mycology: Official Publication of the International Society for Human and Animal Mycology
https://www.readbyqxmd.com/read/29228323/evaluation-of-a-genus-specific-elisa-and-a-commercial-aspergillus-western-blot-igg%C3%A2-immunoblot-kit-for-the-diagnosis-of-aspergillosis-in-common-bottlenose-dolphins-tursiops-truncatus
#3
Guillaume Desoubeaux, Carolina Le-Bert, Vanessa Fravel, Tonya Clauss, Alexa J Delaune, Jeny Soto, Eric D Jensen, Jennifer E Flower, Randall Wells, Gregory D Bossart, Carolyn Cray
Aspergillosis is a fungal infection with high mortality and morbidity rates. As in humans, its definitive diagnosis is difficult in animals, and thus new laboratory tools are required to overcome the diagnostic limitations due to low specificity and lack of standardization. In this study of common bottlenose dolphins (Tursiops truncatus), we evaluated the diagnostic performance of a new commercial immunoblot kit that had been initially developed for the serologic diagnosis of chronic aspergillosis in humans...
December 8, 2017: Medical Mycology: Official Publication of the International Society for Human and Animal Mycology
https://www.readbyqxmd.com/read/29228306/25s-rdna-genotype-and-antifungal-susceptibility-of-clinical-candida-albicans-in-ouagadougou-burkina-faso
#4
Adama Zida, Soulama Issiaka, Bamba Sanata, Serme S Samuel, Sangare Ibrahim, Sawadogo Marcel, Guiguemde Thierry, Traore Lady Kady, Guiguemde T Robert
The present investigation aimed to assess the prevalence of genotypes of C. albicans in Ouagadougou and to analyze the relationship between the genetic diversity and antifungal susceptibility. Ninety-six clinical strains are included. They were diagnosed as C. albicans using germ tube test, chlamydospore formation, and Api-Candida test. Genotyping was performed using PCR targeting 25S rDNA. Antifungal susceptibilities were tested based on the disk diffusion method. The genotypes A (85.4%) was predominant followed by genotypes B (10...
December 8, 2017: Medical Mycology: Official Publication of the International Society for Human and Animal Mycology
https://www.readbyqxmd.com/read/29228268/low-and-constant-micafungin-concentrations-may-be-sufficient-to-lead-to-resistance-mutations-in-fks2-gene-of-candida-glabrata
#5
María Ángeles Bordallo-Cardona, Pilar Escribano, Laura Judith Marcos-Zambrano, Judith Díaz-García, Elia Gómez de la Pedrosa, Rafael Cantón, Emilio Bouza, Jesús Guinea
We studied the ability of five echinocandin-susceptible C. glabrata isolates to acquire in vitro resistance to anidulafungin and micafungin. All isolates became phenotypically resistant after 2-4 days of exposure to low and constant micafungin concentrations (P < .05). Mutations in the HS1 region of the FKS2 gene were found in all isolates. The acquisition of resistance was not related to the previous use of antifungal treatment in the patients or the presence of mutations at MSH2 gene. We found differences (P < ...
December 8, 2017: Medical Mycology: Official Publication of the International Society for Human and Animal Mycology
https://www.readbyqxmd.com/read/29228246/clinical-impact-of-candida-spp-biofilm-production-in-a-cohort-of-patients-with-candidemia
#6
Priscilla Morais Monfredini, Ana Carolina Remondi Souza, Renan Pelluzzi Cavalheiro, Ricardo Andreotti Siqueira, Arnaldo Lopes Colombo
Persistent candidemia refers to the continued isolation of the same Candida species in the blood of a candidemic patient despite appropriate therapy. Despite the clinical importance of persistent candidemia, studies have superficially addressed the biological conditions behind this phenomenon. The aim of this study was to evaluate the correlation between the biofilm-forming ability by Candida bloodstream isolates and the persistence of infection. A total of 55 isolates of Candida were tested and characterized in two groups: (i) group I, which included seven patients with persistent candidemia, and (ii) group II, which included 18 patients with nonpersistent candidemia...
December 8, 2017: Medical Mycology: Official Publication of the International Society for Human and Animal Mycology
https://www.readbyqxmd.com/read/29227929/green-approach-for-the-synthesis-of-thiophenyl-pyrazoles-and-isoxazoles-by-adopting-1-3-dipolar-cycloaddition-methodology-and-their-antimicrobial-activity
#7
D V Sowmya, G Lakshmi Teja, A Padmaja, V Kamala Prasad, V Padmavathi
A variety of N-((1,3-diphenyl-5-aryl-1H-pyrazol-4-yl)sulfonyl)thiophene-2-carboxamides (7) and N-((5-aryl-3-phenylisoxazol-4-yl)sulfonyl)thiophene-2-carboxamides (8) were prepared from (E)-N-(arylethenesulfonyl)thiophene-2-carboxamides (4) adopting 1,3-dipolar cycloaddition of nitrile imines and nitrile oxides generated from araldehyde phenylhydrazones and araldoximes in the presence of iodosobenzene and CTAB followed by oxidation with I2 in DMSO. The compounds 4f, 7e, 7f, 8e and 8f showed potential antibacterial activity against B...
December 5, 2017: European Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/29227917/design-synthesis-molecular-docking-of-new-lipophilic-acetamide-derivatives-affording-potential-anticancer-and-antimicrobial-agents
#8
Hany E A Ahmed, Saleh K Ihmaid, Abdelsattar M Omar, Ahmed M Shehata, Heba S Rateb, Mohammed F Zayed, Sahar Ahmed, Mahmoud M Elaasser
Fifteen new substituted N-2-(2-oxo-3-phenylquinoxalin-1(2H)-yl) acetamides 5a-f, 6a-f, and 8a-c were synthesized by reacting ethyl 2-(2-oxo-3-phenylquinoxalin-1(2H)-yl)acetate with various primary amines including benzylamines, sulfonamides, and amino acids. The in vitro antimicrobial screening of the target compounds was screened to assess their antibacterial and antifungal activity. As a result, seven compounds namely; 5a, 5c, 5d, 6a, 6c, 8b and 8c showed a promising broad spectrum antibacterial activity against both Gram-positive and Gram-negative strains...
December 2, 2017: Bioorganic Chemistry
https://www.readbyqxmd.com/read/29227694/pulsed-electric-field-assisted-sensitization-of-multidrug-resistant-candida-albicans-to-antifungal-drugs
#9
Vitalij Novickij, Jurgita Švedienė, Algimantas Paškevičius, Svetlana Markovskaja, Irutė Girkontaitė, Auksė Zinkevičienė, Eglė Lastauskienė, Jurij Novickij
AIM: Determine the influence of pH on the inactivation efficiency of C. albicans in pulsed electric fields (PEF) and evaluate the possibilities for sensitization of a drug-resistant strain to antifungal drugs. MATERIALS & METHODS: The effects of PEF (2.5-25 kVcm-1) with fluconazole, terbinafine and naftifine were analyzed at a pH range of 3.0-9.0. Membrane permeabilization was determined by flow cytometry and propidium iodide. RESULTS: PEF induced higher inactivation of C...
December 11, 2017: Future Microbiology
https://www.readbyqxmd.com/read/29227574/light-treatments-of-nail-fungal-infections
#10
REVIEW
Jessica Houang, Gabriel Perrone, Damia Mawad, Philip C Boughton, Andrew J Ruys, Antonio Lauto
Nail fungal infections are notoriously persistent and difficult to treat which can lead to severe health impacts, particularly in the immunocompromised. Current antifungal treatments, including systemic and topical drugs, are prolonged and do not effectively provide a complete cure. Severe side effects are also associated with systemic antifungals, such as hepatoxicity. Light treatments of onychomycosis are an emerging therapy that has localised photodynamic, photothermal or photoablative action. These treatments have shown to be an effective alternative to traditional antifungal remedy with comparable or better cure rates achieved in shorter times and without systemic side effects...
December 11, 2017: Journal of Biophotonics
https://www.readbyqxmd.com/read/29227564/novel-mold-resistant-building-materials-impregnated-with-thermally-reduced-nano-silver
#11
Yen-Chi Chen, Kuo-Pin Yu, Wen-Cheng Shao, Chao-Heng Tseng, Wen-Chi Pan
In this study, we evaluated the long-term antifungal effectiveness of 3 types of interior building materials (gypsum board (GB), cement board (CB) and softwood plywood (S-PW)) impregnated with thermally reduced silver nanoparticles supported by titanium dioxide (AgNPs/TiO2 ) under 95% relative humidity for four weeks. AgNPs/TiO2 was synthesized at two thermal reduction temperatures (TRTs, 120 and 200°C) with two different AgNP weight percentages (2 and 5 wt%). Four different silver loading levels (SLLs, 0...
December 11, 2017: Indoor Air
https://www.readbyqxmd.com/read/29227471/inhibiting-mitochondrial-phosphate-transport-as-an-unexploited-antifungal-strategy
#12
Catherine A McLellan, Benjamin M Vincent, Norma V Solis, Alex K Lancaster, Lucas B Sullivan, Cathy L Hartland, Willmen Youngsaye, Scott G Filler, Luke Whitesell, Susan Lindquist
The development of effective antifungal therapeutics remains a formidable challenge because of the close evolutionary relationship between humans and fungi. Mitochondrial function may present an exploitable vulnerability because of its differential utilization in fungi and its pivotal roles in fungal morphogenesis, virulence, and drug resistance already demonstrated by others. We now report mechanistic characterization of ML316, a thiohydantoin that kills drug-resistant Candida species at nanomolar concentrations through fungal-selective inhibition of the mitochondrial phosphate carrier Mir1...
December 11, 2017: Nature Chemical Biology
https://www.readbyqxmd.com/read/29227087/new-application-of-neomycin-b-bisbenzimidazole-hybrids-as-antifungal-agents
#13
Nishad Thamban Chandrika, Sanjib K Shrestha, Nihar Ranjan, Anindra Sharma, Dev P Arya, Sylvie Garneau-Tsodikova
Alkylated aminoglycosides and bisbenzimidazoles have previously been shown to individually display antifungal activity. Herein, we explore for the first time the antifungal activity (in liquid cultures and in biofilms) of ten alkylated aminoglycosides covalently linked to either mono- or bisbenzimidazoles. We also investigate their toxicity against mammalian cells, their hemolytic activity, and their potential mechanism(s) of action (inhibition of fungal ergosterol biosynthetic pathway and/or reactive oxygen species (ROS) production)...
December 11, 2017: ACS Infectious Diseases
https://www.readbyqxmd.com/read/29226215/in-vitro-antifungal-activity-of-hexahydropyrimidine-derivatives-against-the-causative-agents-of-dermatomycosis
#14
Francislene J Martins, César A Caneschi, Mônica P Senra, Gustavo S G Carvalho, Adilson D da Silva, Nádia R B Raposo
Nitrogenated heterocyclic compounds are present in both natural and synthetic drugs, and hexahydropyrimidine derivatives may prove to be efficient in treating dermatomycosis causing fungi. This study evaluated the antifungal activity of four hexahydropyrimidine derivatives against the dermatomycosis causing fungi. These derivatives were synthesized, characterized, and assessed in terms of their activity against Trichophyton mentagrophytes, Microsporum canis, Microsporum gypseum, Trichophyton rubrum, Fusarium oxysporum, and Epidermophyton floccosum between concentrations 7...
2017: TheScientificWorldJournal
https://www.readbyqxmd.com/read/29226147/antifungal-activity-of-aqueous-extracts-of-some-dominant-algerian-medicinal-plants
#15
Nasrine Salhi, Sultan Ayesh Mohammed Saghir, Valeria Terzi, Iman Brahmi, Naima Ghedairi, Samia Bissati
Aim: This study investigated the antifungal properties of aqueous extracts obtained from indigenous plants that grow spontaneously in the Northern Sahara of Algeria. The activities of these plants in controlling two fungal species that belong to Fusarium genus were evaluated in an in vitro assay. Materials and Methods: Fresh aerial parts of four plant species (Artemisia herba alba, Cotula cinerea, Asphodelus tenuifolius, and Euphorbia guyoniana) were collected for the preparation of aqueous extracts...
2017: BioMed Research International
https://www.readbyqxmd.com/read/29225910/reduced-susceptibility-to-fluconazole-in-a-cat-with-histoplasmosis
#16
Janelle S Renschler, Gary D Norsworthy, Rubie A Rakian, Audrey I Rakian, Lawrence J Wheat, Andrew S Hanzlicek
Case summary: An 11-year-old neutered male domestic longhair cat was diagnosed with histoplasmosis from fine-needle aspirates of an abdominal lymph node. Lymph node size initially decreased with fluconazole therapy (11.8 mg/kg PO q12h); however, after 13 months of continuous fluconazole therapy, lymphadenomegaly worsened and samples were collected for culture and antifungal susceptibility. The Histoplasma capsulatum isolate had a very high fluconazole minimum inhibitory concentration (MIC) of 64 µg/ml and an itraconazole MIC of 0...
July 2017: JFMS Open Reports
https://www.readbyqxmd.com/read/29225834/thrombocytopenia-and-disseminated-histoplasmosis-in-immunocompetent-adults
#17
Issa Kutkut, Laura Vater, Mitchell Goldman, Magdalena Czader, Jessica Swenberg, Zachary Fulkerson, Rakesh Mehta
Disseminated histoplasmosis among immunocompetent patients is rare, but may be associated with clinically significant refractory thrombocytopenia. Platelet counts often return to normal levels following antifungal therapy. Therefore, the most important management of this refractory thrombocytopenia is the recognition and treatment of histoplasmosis infection.
December 2017: Clinical Case Reports
https://www.readbyqxmd.com/read/29225729/draft-genome-sequence-of-bacillus-velezensis-2a-2b-strain-a-rhizospheric-inhabitant-of-sporobolus-airoides-torr-torr-with-antifungal-activity-against-root-rot-causing-phytopathogens
#18
Inés Martínez-Raudales, Yumiko De La Cruz-Rodríguez, Alejandro Alvarado-Gutiérrez, Julio Vega-Arreguín, Ahuitz Fraire-Mayorga, Miguel Alvarado-Rodríguez, Victor Balderas-Hernández, Saúl Fraire-Velázquez
A Bacillus velezensis strain from the rhizosphere of Sporobolus airoides (Torr.) Torr., a grass in central-north México, was isolated during a biocontrol of phytopathogens scrutiny study. The 2A-2B strain exhibited at least 60% of growth inhibition of virulent isolates of phytopathogens causing root rot. These phytopathogens include Phytophthora capsici, Fusarium solani, Fusarium oxysporum and Rhizoctonia solani. Furthermore, the 2A-2B strain is an indolacetic acid producer, and a plant inducer of PR1, which is an induced systemic resistance related gene in chili pepper plantlets...
2017: Standards in Genomic Sciences
https://www.readbyqxmd.com/read/29225593/diverse-cone-snail-species-harbor-closely-related-streptomyces-species-with-conserved-chemical-and-genetic-profiles-including-polycyclic-tetramic-acid-macrolactams
#19
Michelle Quezada, Cuauhtemoc Licona-Cassani, Pablo Cruz-Morales, Angela A Salim, Esteban Marcellin, Robert J Capon, Francisco Barona-Gómez
Streptomyces are Gram-positive bacteria that occupy diverse ecological niches including host-associations with animals and plants. Members of this genus are known for their overwhelming repertoire of natural products, which has been exploited for almost a century as a source of medicines and agrochemicals. Notwithstanding intense scientific and commercial interest in Streptomyces natural products, surprisingly little is known of the intra- and/or inter-species ecological roles played by these metabolites. In this report we describe the chemical structures, biological properties, and biosynthetic relationships between natural products produced by Streptomyces isolated from internal tissues of predatory Conus snails, collected from the Great Barrier Reef, Australia...
2017: Frontiers in Microbiology
https://www.readbyqxmd.com/read/29225201/3-bromopyruvate-as-a-potential-pharmaceutical-in-the-light-of-experimental-data
#20
Izabela Szczuka, Andrzej Gamian, Grzegorz Terlecki
3-Bromopyruvate (3-BrPA) is an halogenated analogue of pyruvic acid known for over four decades as an alkylating agent reacting with thiol groups of many proteins. It enters animal cells like a lactate: via monocarboxylic acid transporters. Increasing interest in this compound, in recent times, is mainly due to hopes associated with its anticancer action. It is based on the impairment of energy metabolism of tumor cells by inhibiting enzymes in the glycolysis pathway (hexokinase II, glyceraldehyde 3-phosphate dehydrogenase, phosphoglycerate kinase) and the oxidative phosphorylation (succinate dehydrogenase)...
December 8, 2017: Postȩpy Higieny i Medycyny Doświadczalnej
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