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JOURNAL ARTICLE
Lais Ceschini Machado, Filipe Zimmer Dezordi, Gustavo Barbosa de Lima, Raul Emídio de Lima, Lilian Caroliny Amorim Silva, Leandro de Mattos Pereira, Alexandre Freitas da Silva, Antonio Marinho da Silva Neto, André Luiz Sá de Oliveira, Anderson da Costa Armstrong, Rômulo Pessoa-E-Silva, Rodrigo Moraes Loyo, Barbara de Oliveira Silva, Anderson Rodrigues de Almeida, Maira Galdino da Rocha Pitta, Francisco de Assis da Silva Santos, Marilda Mendonça Siqueira, Paola Cristina Resende, Edson Delatorre, Felipe Gomes Naveca, Fabio Miyajima, Tiago Gräf, Rodrigo Feliciano do Carmo, Michelly Cristiny Pereira, Tulio de Lima Campos, Matheus Filgueira Bezerra, Marcelo Henrique Santos Paiva, Gabriel da Luz Wallau
SARS-CoV-2 virus emerged as a new threat to humans and spread around the world, leaving a large death toll. As of January 2023, Brazil is among the countries with the highest number of registered deaths. Nonpharmacological and pharmacological interventions have been heterogeneously implemented in the country, which, associated with large socioeconomic differences between the country regions, has led to distinct virus spread dynamics. Here, we investigate the spatiotemporal dispersion of SARS-CoV-2 lineages in the Pernambuco state (Northeast Brazil) throughout the distinct epidemiological scenarios that unfolded in the first 2 years of the pandemic...
April 23, 2024: Microbiology Spectrum
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JOURNAL ARTICLE
Norazrin Ariffin, David Wells Newman, Michael G Nelson, Ronan O'cualain, Simon J Hubbard
MD2 pineapple ( Ananas comosus ) is the second most important tropical crop that preserves crassulacean acid metabolism (CAM), which has high water-use efficiency and is fast becoming the most consumed fresh fruit worldwide. Despite the significance of environmental efficiency and popularity, until very recently, its genome sequence has not been determined and a high-quality annotated proteome has not been available. Here, we have undertaken a pilot proteogenomic study, analyzing the proteome of MD2 pineapple leaves using liquid chromatography-mass spectrometry (LC-MS/MS), which validates 1781 predicted proteins in the annotated F153 (V3) genome...
April 23, 2024: Journal of Proteome Research
#3
JOURNAL ARTICLE
K Krishnaram, T Suresh Padmanabhan, Faisal Alsaif, S Senthilkumar
The conventional MPPT method has drawbacks, such as that under partial shading conditions, several peaks occur and identifying the global peak is difficult. It may converge to a local peak and lead to poor conversion efficiency and tracking efficiency. Implementation of a hybrid algorithm by integrating P&O and metaheuristic algorithms can perform better under partial shading conditions. But the tracking speed is low and the response time is longer. To mitigate the issues mentioned above, a new hybrid algorithm has been suggested that integrates GWO and a modified fast terminal sliding mode controller (MFTSMC)...
April 22, 2024: Scientific Reports
#4
JOURNAL ARTICLE
Hifzur Rahman, Prashant Vikram, Yulan Hu, Sugandha Asthana, Abhinav Tanaji, Padmaktshni Suryanarayanan, Chris Quadros, Lovely Mehta, Mohammed Shahid, Anestis Gkanogiannis, Sumitha Thushar, Salma Balazadeh, Bernd Mueller-Roeber, Luis Augusto Becerra Lopez-Lavalle, Tong Wei, Rakesh Kumar Singh
Quinoa (Chenopodium quinoa Willd.), an Andean crop, is a facultative halophyte food crop recognized globally for its high nutritional value and plasticity to adapt to harsh conditions. We conducted a genome-wide association study on a diverse set of quinoa germplasm accessions. These accessions were evaluated for the following agronomic and biochemical traits: days to 50% flowering (DTF), plant height (PH), panicle length (PL), stem diameter (SD), seed yield (SY), grain diameter (GD), and thousand-grain weight (TGW)...
April 22, 2024: Scientific Reports
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JOURNAL ARTICLE
Wenqian Wang, Md Musfizur Hassan, Natasha Kapoor-Kaushik, Lital Livni, Benjamin Musrie, Jianbo Tang, Zaheri Mahmud, Saluo Lai, Peter Richard Wich, Vaishnavi Ananthanarayanan, Gila Moalem-Taylor, Guangzhao Mao
Neural tracing proteins like horseradish peroxidase-conjugated wheat germ agglutinin (WGA-HRP) can target the central nervous system (CNS) through anatomic retrograde transport without crossing the blood-brain barrier (BBB). Conjugating WGA-HRP to nanoparticles may enable the creation of BBB-bypassing nanomedicine. Microfluidics and two-photon confocal microscopy is applied to screen nanocarriers for transport efficacy and gain mechanistic insights into their interactions with neurons. Protein modification of gold nanoparticles alters their cellular uptake at the axonal terminal and activates fast retrograde transport...
April 22, 2024: Small
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JOURNAL ARTICLE
Jeffry M Gaston, Eric J Alm, An-Ni Zhang
BACKGROUND: Accurate identification of genetic variants, such as point mutations and insertions/deletions (indels), is crucial for various genetic studies into epidemic tracking, population genetics, and disease diagnosis. Genetic studies into microbiomes often require processing numerous sequencing datasets, necessitating variant identifiers with high speed, accuracy, and robustness. RESULTS: We present QuickVariants, a bioinformatics tool that effectively summarizes variant information from read alignments and identifies variants...
April 22, 2024: BMC Biology
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JOURNAL ARTICLE
Nils A Koch, Patrice Voss, J Miguel Cisneros-Franco, Alexandre Drouin-Picaro, Fama Tounkara, Simon Ducharme, Daniel Guitton, Étienne de Villers-Sidani
Studying the oculomotor system provides a unique window to assess brain health and function in various clinical populations. Although the use of detailed oculomotor parameters in clinical research has been limited due to the scalability of the required equipment, the development of novel tablet-based technologies has created opportunities for fast, easy, cost-effective, and reliable eye tracking. Oculomotor measures captured via a mobile tablet-based technology have previously been shown to reliably discriminate between Parkinson's Disease (PD) patients and healthy controls...
April 20, 2024: Scientific Reports
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JOURNAL ARTICLE
Sara Torres-Esquius, Francisco Beas, Tzu Hua Chen-Liang, Helena Pomares, Marta Santiago, Nicolás Díaz Varela, Alessandro Liquori, Francisca Hernandez, Blanca Xicoy, Lourdes Hermosín, Montserrat Arnan, Bárbara Tazón-Vega, Adoración Blanco, José Cervera, María Diez-Campelo, María Luisa Lozano, David Valcárcel, Francesc Bosch, Maria Julia Montoro, Andrés Jerez
Patients aged 50 or above diagnosed with myeloid neoplasms (MNs) are typically not candidates for germline testing. However, approximately 8% carry pathogenic germline variants. Allogeneic haematopoietic stem cell transplantation (alloHSCT) remains an option for those aged over 50; neglecting germline testing could mask the risk for relative donor cell-derived MN. We propose a germline-augmented somatic panel (GASP), combining MN predisposition genes with a myeloid somatic panel for timely germline variant identification when initial testing is not indicated...
April 19, 2024: British Journal of Haematology
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JOURNAL ARTICLE
Jinna Fu, Xingyi Liu, Yingqiang Liu, Zheng Chen, Bin Yao
This paper presents a two-loop control framework for robotic manipulator systems subject to state constraints and input saturation, which effectively integrates planning and control strategies. Namely, a stability controller is designed in the inner loop to address uncertainties and nonlinearities; an optimization-based generator is constructed in the outer loop to ensure that state and input constraints are obeyed while concurrently minimizing the convergence time. Furthermore, to dramatically the computational burden, the optimization-based generator in the outer loop is switched to a direct model-based generator when the tracking errors are sufficiently small...
April 13, 2024: ISA Transactions
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JOURNAL ARTICLE
Avri Giammanco, Andrey Bychkov, Simon Schallenberg, Tsvetan Tsvetkov, Junya Fukuoka, Alexey Pryalukhin, Fabian Mairinger, Alexander Seper, Wolfgang Hulla, Sebastian Klein, Alexander Quaas, Reinhard Büttner, Yuri Tolkach
Lymph node metastasis (LNM) detection can be automated using artificial intelligence-based diagnostic tools. Only limited studies have addressed this task for colorectal cancer. The aim of this study was to develop of a clinical-grade digital pathology tool for LNM detection in colorectal cancer (CRC) using the original fast-track framework. The training cohort included 432 slides from one department. A segmentation algorithm detecting 8 relevant tissue classes was trained. The test cohorts consisted of materials from five pathology departments digitized by four different scanning systems...
April 16, 2024: Modern Pathology
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JOURNAL ARTICLE
Van Tuong Pham, Naveen Sisodia, Ilaria Di Manici, Joseba Urrestarazu-Larrañaga, Kaushik Bairagi, Johan Pelloux-Prayer, Rodrigo Guedas, Liliana D Buda-Prejbeanu, Stéphane Auffret, Andrea Locatelli, Tevfik Onur Menteş, Stefania Pizzini, Pawan Kumar, Aurore Finco, Vincent Jacques, Gilles Gaudin, Olivier Boulle
Magnetic skyrmions are topological magnetic textures that hold great promise as nanoscale bits of information in memory and logic devices. Although room-temperature ferromagnetic skyrmions and their current-induced manipulation have been demonstrated, their velocity has been limited to about 100 meters per second. In addition, their dynamics are perturbed by the skyrmion Hall effect, a motion transverse to the current direction caused by the skyrmion topological charge. Here, we show that skyrmions in compensated synthetic antiferromagnets can be moved by current along the current direction at velocities of up to 900 meters per second...
April 19, 2024: Science
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JOURNAL ARTICLE
Busra Firlatan, Ugur Nadir Karakulak, Vedat Hekimsoy, Burcin Gonul Iremli, Incilay Lay, Deniz Yuce, Selcuk Dagdelen, Giray Kabakci, Tomris Erbas
PURPOSE: In patients with acromegaly, the long-term presence of elevated GH and IGF-1 levels is associated with an unfavorable cardiovascular risk profile. We aimed to assess the relationship of four-dimensional speckle tracking echocardiographic (4DSTE) measurements with growth differentiation factor-15 (GDF-15) levels and the Framingham Cardiovascular Risk Score (FRS) in patients with acromegaly. METHODS: A single-center, cross-sectional study was conducted. The study included 40 acromegaly and 32 age- and gender-matched controls...
April 18, 2024: Hormones: International Journal of Endocrinology and Metabolism
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JOURNAL ARTICLE
Prudhvi Dasari, Maheeja Reddy, Dileep Singh Parmar, Carl Britto
A man in his 30s was involved in a road traffic crash in a small town in India, not equipped to deal with cases of brainstem death. He was declared brain-dead after a few hours. The patient's information was forwarded to organ specialists across the country, with the goal of preserving the patient's organs for donation via a tele-ICU model. The team comprising bedside doctors and remote intensivists communicating via an indigenously developed tele-ICU platform managed the patient for 24 hours, following treatment protocols and providing critical care to ensure that the patient's vital organs were optimally perfused...
April 16, 2024: BMJ Case Reports
#14
JOURNAL ARTICLE
Sixian Liu, Zhixin Wu, Zhilong He, Weilin Chen, Xiaolong Zhong, Bingjie Guo, Shuzhi Liu, Hongxiao Duan, Yanbo Guo, Jianmin Zeng, Gang Liu
The advancement of artificial intelligent vision systems heavily relies on the development of fast and accurate optical imaging detection, identification, and tracking. Framed by restricted response speeds and low computational efficiency, traditional optoelectronic information devices are facing challenges in real-time optical imaging tasks and their ability to efficiently process complex visual data. To address the limitations of current optoelectronic information devices, this study introduces a novel photomemristor utilizing halide perovskite thin films...
April 16, 2024: ACS Applied Materials & Interfaces
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JOURNAL ARTICLE
C E Bekolo, S A Ndeso, L L Moifo, N Mangala, J Ateudjieu, C Kouanfack, A Dzudie, F Thienemann, N Tendongfor, D S Nsagha, S P Choukem
Cameroon adopted and started implementing in 2016, the 'universal test and treat' (UTT) guidelines to fast-track progress towards the 95-95-95 ambitious targets to end the HIV epidemic. Achieving the third 95 (viral load suppression) is the most desirable target in HIV care. We aimed to evaluate the effectiveness of this novel approach on access to viral load testing (VLT), viral suppression (VLS), and viral load rebound (VLR). A retrospective cohort study was conducted at The Nkongsamba Regional Hospital to compare VLT outcomes between the pre-UTT (2002 to 2015) and the post-UTT (2016 to 2020) periods...
2024: PLOS Glob Public Health
#16
JOURNAL ARTICLE
Michael K Wong, Cassian Yee
Merkel cell carcinoma (MCC) is an aggressive, fast-growing, highly metastatic neuroendocrine skin cancer. The Merkel cell polyomavirus (MCPyV) is an oncogenic driver in the majority of MCC tumors. In this issue of the JCI, Hansen and authors report on their tracking of CD8+ T cells reactive to MCPyV T antigen (T-Ag) in the peripheral blood of 26 patients with MCC who were undergoing frontline anti-programmed cell death protein-1 (anti-PD-1) immunotherapy. They discovered unique T cell epitopes and used the power of bar-coded tetramers to portray immune checkpoint inhibitor-induced immunogenicity as a predictor of clinical response...
April 15, 2024: Journal of Clinical Investigation
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REVIEW
Ruta Virsinskaite, Nina Karia, Tushar Kotecha, Benjamin E Schreiber, J Gerry Coghlan, Daniel S Knight
Pulmonary hypertension (PH) is common, with an estimated prevalence of approximately 1% that increases with age. Prompt and accurate diagnosis is key to institute timely and appropriate therapy to improve symptoms and prognosis. The international guidelines for the diagnosis and management of PH have recently been updated, with a lowering of the haemodynamic threshold for diagnosis to a mean pulmonary artery pressure >20 mmHg. New diagnostic algorithms and revised indications for screening in at-risk groups have been developed to facilitate early referral to specialist PH centres...
September 2023: Clinical Medicine: Journal of the Royal College of Physicians of London
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JOURNAL ARTICLE
Sonja C Mansfield Smith, Mustafa R Al-Hashimi, Colin D Jones, Chetan B Mukhtyar
BACKGROUND: We present the largest study of the frequency and nature of visual complications in a cohort of 350 patients consecutively diagnosed with giant cell arteritis (GCA). METHODS: All individuals were assessed using structured forms and diagnosed using imaging or biopsy. A binary logistic regression model was used to analyse data for predicting visual loss. RESULTS: Visual symptoms occurred in 101 (28.9%) patients, with visual loss in one or both eyes in 48 (13...
May 2023: Clinical Medicine: Journal of the Royal College of Physicians of London
#19
JOURNAL ARTICLE
Magdalena Luty-Błocho, Jowita Cyndrowska, Bogdan Rutkowski, Volker Hessel
In this work, UV-Vis spectrophotometry, High Resolution Scanning Transmission Electron Microscopes and selected experimental conditions were used to screen the colloidal system. The obtained results complement the established knowledge regarding the mechanism of nanoparticle formation. The process of gold nanoparticles formation involves a two-step reduction of Au ions to Au(0); atom association and metastable cluster formation; autocatalytic cluster growth; ultra-small particle formation (1-2 nm, in diameter); particle growth and larger particles formation; and further autocatalytic crystal growth (D > 100 nm)...
March 22, 2024: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
#20
JOURNAL ARTICLE
Hannes Gruber, Anna Fuchs, Michael Bader
Roller bearings are critical components in various mechanical systems, and the timely detection of potential failures is essential for preventing costly downtimes and avoiding substantial machinery breakdown. This research focuses on finding and verifying a robust method that can detect failures early, without creating false positive failure states. Therefore, this paper introduces a novel algorithm for the early detection of roller bearing failures, particularly tailored to high-precision bearings and automotive test bed systems...
March 27, 2024: Sensors
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