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https://www.readbyqxmd.com/read/28526787/development-of-multi-well-plate-methods-using-pure-cultures-of-methanogens-to-identify-new-inhibitors-for-suppressing-ruminant-methane-emissions
#1
M R Weimar, J Cheung, D Dey, C McSweeney, M Morrison, Y Kobayashi, W B Whitman, V Carbone, L R Schofield, R S Ronimus, G M Cook
Hydrogenotrophic methanogens typically require strictly anaerobic culturing conditions in glass tubes with overpressures of H2 and CO2 that are both time-consuming and costly. To increase the throughput for screening chemical compound libraries, 96-well microtiter plate methods for the growth of a marine (environmental) methanogen Methanococcus maripaludis strain S2 and the rumen methanogen Methanobrevibacter species AbM4 were developed. A number of key parameters (inoculum size, reducing agents for media preparation, duration of assay, inhibitor solvents and culture volume) were optimised to achieve robust and reproducible growth in a high-throughput microtiter plate format...
May 19, 2017: Applied and Environmental Microbiology
https://www.readbyqxmd.com/read/28523068/importance-of-publication-audit-fast-track-processing-and-categorization-of-manuscripts
#2
Shaukat Ali Jawaid
No abstract text is available yet for this article.
March 2017: Pakistan Journal of Medical Sciences Quarterly
https://www.readbyqxmd.com/read/28521787/robot-assisted-thoracoscopic-lobectomy-as-treatment-of-a-giant-bulla
#3
Rosa Roemers, Kornelis Patberg, Caroline van de Wauwer, Tam Nguyen, Ghada Shahin
BACKGROUND: A bulla is a marked enlarged space within the parenchyma of the lung. Bullae may cause dyspnea by compressing healthy lung parenchyma and can cause a pneumothorax. Also, bullae are associated with malignancy, therefore surgical bullectomy is indicated on preventive basis. This case is unique and therefore valuable because of the remarkable presentation, innovative treatment and the spectacular improvement of lung function and socio-economic performance of the patient. CASE PRESENTATION: In this case report we describe the presentation, minimally invasive surgical treatment by means of a robot-assisted lobectomy and postoperative outcome of a young patient with a giant congenital bulla of the left upper lobe...
May 18, 2017: Journal of Cardiothoracic Surgery
https://www.readbyqxmd.com/read/28512073/identifying-ethical-issues-in-the-development-of-vaccines-and-in-vaccination
#4
Veena Johari
Vaccines are a widely accepted public health intervention. They are also a profitable tool for pharmaceutical companies manufacturing vaccines. There are many vaccines in the pipeline, for various diseases, or as combination vaccines for several diseases. However, there is also a growing concern about vaccines and the manner in which they are developed and approved by the authorities. Approvals are fast tracked and adverse events and serious adverse events following vaccination are seldom reported once the vaccine gets its marketing approval...
April 2017: Indian Journal of Medical Ethics
https://www.readbyqxmd.com/read/28511195/safety-aspects-of-postanesthesia-care-unit-discharge-without-motor-function-assessment-after-spinal-anesthesia-a-randomized-multicenter-semiblinded-noninferiority-controlled-trial
#5
Eske Kvanner Aasvang, Christoffer Calov Jørgensen, Mogens Berg Laursen, Jacob Madsen, Søren Solgaard, Mogens Krøigaard, Per Kjærsgaard-Andersen, Hans Mandøe, Torben Bæk Hansen, Jørgen Ulrich Nielsen, Niels Krarup, Annette Elisabeth Skøtt, Henrik Kehlet
BACKGROUND: Postanesthesia care unit (PACU) discharge without observation of lower limb motor function after spinal anesthesia has been suggested to significantly reduce PACU stay and enhance resource optimization and early rehabilitation but without enough data to allow clinical recommendations. METHODS: A multicenter, semiblinded, noninferiority randomized controlled trial of discharge from the PACU with or without assessment of lower limb motor function after elective total hip or knee arthroplasty under spinal anesthesia was undertaken...
June 2017: Anesthesiology
https://www.readbyqxmd.com/read/28508720/human-kinematics-of-cochlear-implant-surgery-an-investigation-of-insertion-micro-motions-and-speed-limitations
#6
Kyle Kesler, Neal P Dillon, Loris Fichera, Robert F Labadie
Objectives Document human motions associated with cochlear implant electrode insertion at different speeds and determine the lower limit of continuous insertion speed by a human. Study Design Observational. Setting Academic medical center. Subjects and Methods Cochlear implant forceps were coupled to a frame containing reflective fiducials, which enabled optical tracking of the forceps' tip position in real time. Otolaryngologists (n = 14) performed mock electrode insertions at different speeds based on recommendations from the literature: "fast" (96 mm/min), "stable" (as slow as possible without stopping), and "slow" (15 mm/min)...
May 1, 2017: Otolaryngology—Head and Neck Surgery
https://www.readbyqxmd.com/read/28507667/photoacoustic-probes-for-real-time-tracking-of-endogenous-h2s-in-living-mice
#7
Ben Shi, Xianfeng Gu, Qiang Fei, Chunchang Zhao
H2S is a key chemical mediator that exerts a vital role in diverse physiological and pathological processes. However, in vivo tracking of endogenous H2S generation still remains difficult due to the lack of reliable analytical methods. Herein, we present the first example of activatable photoacoustic probes for real-time imaging of H2S in living mice through the full utilization of the superiority of photoacoustic imaging modality at fine spatial resolution during deep tissue penetration. The designed probe can generate high NIR absorption at 780 nm in the presence of H2S, thus producing a strong photoacoustic signal output in the NIR region...
March 1, 2017: Chemical Science
https://www.readbyqxmd.com/read/28506879/a-new-platform-for-long-term-tracking-and-recording-of-neural-activity-and-simultaneous-optogenetic-control-in-freely-behaving-caenorhabditis-elegans
#8
Keiko Gengyo-Ando, Yuko Kagawa-Nagamura, Masamichi Ohkura, Xianfeng Fei, Min Chen, Koichi Hashimoto, Junichi Nakai
BACKGROUND: Real-time recording and manipulation of neural activity in freely behaving animals can greatly advance our understanding of how neural circuits regulate behavior. Ca(2+) imaging and optogenetic manipulation with optical probes are key technologies for this purpose. However, integrating the two optical approaches with behavioral analysis has been technically challenging. NEW METHOD: Here, we developed a new imaging system, ICaST (Integrated platform for Ca(2+) imaging, Stimulation, and Tracking), which combines an automatic worm tracking system and a fast-scanning laser confocal microscope, to image neurons of interest in freely behaving C...
May 12, 2017: Journal of Neuroscience Methods
https://www.readbyqxmd.com/read/28498712/fast-diffusion-of-long-guest-rods-in-a-lamellar-phase-of-short-host-particles
#9
Laura Alvarez, M Paul Lettinga, Eric Grelet
We investigate the dynamic behavior of long guest rodlike particles immersed in liquid crystalline phases formed by shorter host rods, tracking both guest and host particles by fluorescence microscopy. Counterintuitively, we evidence that long rods diffuse faster than short rods forming the one-dimensional ordered smectic-A phase. This results from the larger and noncommensurate size of the guest particles as compared to the wavelength of the energy landscape set by the lamellar stack of liquid slabs. The long guest particles are also shown to be still mobile in the crystalline smectic-B phase, as they generate their own voids in the adjacent layers...
April 28, 2017: Physical Review Letters
https://www.readbyqxmd.com/read/28498679/observation-of-the-isovector-giant-monopole-resonance-via-the-28-si-10-be-10-b-1-74%C3%A2-%C3%A2-mev-reaction-at-100%C3%A2-%C3%A2-amev
#10
M Scott, R G T Zegers, R Almus, Sam M Austin, D Bazin, B A Brown, C Campbell, A Gade, M Bowry, S Galès, U Garg, M N Harakeh, E Kwan, C Langer, C Loelius, S Lipschutz, E Litvinova, E Lunderberg, C Morse, S Noji, G Perdikakis, T Redpath, C Robin, H Sakai, Y Sasamoto, M Sasano, C Sullivan, J A Tostevin, T Uesaka, D Weisshaar
The (^{10}Be,^{10}B^{*}[1.74  MeV]) charge-exchange reaction at 100  AMeV is presented as a new probe for isolating the isovector (ΔT=1) nonspin-transfer (ΔS=0) response of nuclei, with ^{28}Si being the first nucleus studied. By using a secondary ^{10}Be beam produced by fast fragmentation of ^{18}O nuclei at the NSCL Coupled Cyclotron Facility, applying the dispersion-matching technique with the S800 magnetic spectrometer to determine the excitation energy in ^{28}Al, and performing high-resolution γ-ray tracking with the Gamma-Ray Energy Tracking In-beam Nuclear Array (GRETINA) to identify the 1022-keV γ ray associated with the decay from the 1...
April 28, 2017: Physical Review Letters
https://www.readbyqxmd.com/read/28495690/intensive-care-in-thoracic-oncology
#11
Anne-Pascale Meert, Bogdan Grigoriu, Marc Licker, Paul E Van Schil, Thierry Berghmans
The admission of lung cancer patients to intensive care is related to postprocedural/postoperative care and medical complications due to cancer or its treatment, but is also related to acute organ failure not directly related to cancer.Despite careful preoperative risk management and the use of modern surgical and anaesthetic techniques, thoracic surgery remains associated with high morbidity, related to the extent of resection and specific comorbidities. Fast-tracking processes with timely recognition and treatment of complications favourably influence patient outcome...
May 2017: European Respiratory Journal: Official Journal of the European Society for Clinical Respiratory Physiology
https://www.readbyqxmd.com/read/28494919/multimodal-therapy-facilitates-a-fast-track-recovery-after-surgery-are-potential-drug-drug-interactions-of-clinical-significance-in-the-perioperative-period
#12
EDITORIAL
https://www.readbyqxmd.com/read/28494481/enhanced-hip-fracture-management-use-of-statistical-methods-and-dataset-to-evaluate-a-fractured-neck-of-femur-fast-track-pathway-pilot-study
#13
Nigel Gilchrist, Kristian Dalzell, Scott Pearson, Gary Hooper, Kit Hoeben, Jeremy Hickling, John McKie, Ma Yi, Sandra Chamberlain, Caroline McCullough, Marc Gutenstein
The increasing elderly population and subsequent rise in total hip fracture(s) in this group means more effective management strategies are necessary to improve efficiency. We have changed our patient care strategy from the emergency department (ED), acute orthopaedic wards, operating theatre, post-operation and rehabilitation, and called it Fracture Neck of Femur Fast Track Pathway. All clinical data and actions were captured, integrated and displayed on a weekly basis using 'signalfromnoise' (SFN) software...
May 12, 2017: New Zealand Medical Journal
https://www.readbyqxmd.com/read/28493526/real-time-mri-guidance-of-cardiac-interventions
#14
Adrienne E Campbell-Washburn, Mohammad A Tavallaei, Mihaela Pop, Elena K Grant, Henry Chubb, Kawal Rhode, Graham A Wright
Cardiac magnetic resonance imaging (MRI) is appealing to guide complex cardiac procedures because it is ionizing radiation-free and offers flexible soft-tissue contrast. Interventional cardiac MR promises to improve existing procedures and enable new ones for complex arrhythmias, as well as congenital and structural heart disease. Guiding invasive procedures demands faster image acquisition, reconstruction and analysis, as well as intuitive intraprocedural display of imaging data. Standard cardiac MR techniques such as 3D anatomical imaging, cardiac function and flow, parameter mapping, and late-gadolinium enhancement can be used to gather valuable clinical data at various procedural stages...
May 11, 2017: Journal of Magnetic Resonance Imaging: JMRI
https://www.readbyqxmd.com/read/28493435/a-fast-peak-searching-algorithm-for-ultrasonic-elastography
#15
Si Chen, Wenxia Wang, Hui Zhang, Jiajun Wang
Tissue axial strain estimation with ultrasound elastography has become a hot field in recent years. However, for keypoints tracking-based elastography algorithms, locating extrema in multimodal ultrasonic radiofrequency signals is still a challenging problem. In this paper, a new method is proposed to locate the local maxima and minima of the RF signals directly without derivation operation. This algorithm can accurately locate extrema even if disturbed peaks resulting from different noise exist. Furthermore, the new algorithm can speed up approximately 79% of the implementation process as compared with the standard cross-correlation method on the same computing platform...
May 11, 2017: Journal of Ultrasound in Medicine: Official Journal of the American Institute of Ultrasound in Medicine
https://www.readbyqxmd.com/read/28486214/microdosimetry-calculations-for-monoenergetic-electrons-using-geant4-dna-combined-with-a-weighted-track-sampling-algorithm
#16
Gabriel Famulari, Piotr Pater, Shirin Enger
PURPOSE: The aim of this study was to calculate microdosimetric distributions for low energy electrons simulated using the Monte Carlo track structure code Geant4-DNA. MATERIALS AND METHODS: Tracks for monoenergetic electrons with kinetic energies ranging from 100 eV to 1 MeV were simulated in an infinite spherical water phantom using the Geant4-DNA extension included in Geant4 toolkit version 10.2 (patch 02). The microdosimetric distributions were obtained through random sampling of transfer points and overlaying scoring volumes within the associated volume of the tracks...
May 9, 2017: Physics in Medicine and Biology
https://www.readbyqxmd.com/read/28484738/hippocampus-dependent-goal-localization-by-head-fixed-mice-in-virtual-reality
#17
Masaaki Sato, Masako Kawano, Kotaro Mizuta, Tanvir Islam, Min Goo Lee, Yasunori Hayashi
The demonstration of the ability of rodents to navigate in virtual reality (VR) has made it an important behavioral paradigm for studying spatially modulated neuronal activity in these animals. However, their behavior in such simulated environments remains poorly understood. Here, we show that encoding and retrieval of goal location memory in mice head-fixed in VR depends on the postsynaptic scaffolding protein Shank2 and the dorsal hippocampus. In our newly developed virtual cued goal location task, a head-fixed mouse moves from one end of a virtual linear track to seek rewards given at a target location along the track...
May 2017: ENeuro
https://www.readbyqxmd.com/read/28483313/immediate-hypersensitivity-reaction-to-chemotherapeutic-agents
#18
Pedro Giavina-Bianchi, Sarita U Patil, Aleena Banerji
An increase by 70% in new cases of cancer is expected over the next 2 decades, with more than 8 million people dying each year from the disease, an estimated 13% of all deaths worldwide. Several new chemotherapeutic agents have been rapidly developed and many of them approved through a fast-track process. In parallel, adverse reactions to chemotherapy have increased dramatically worldwide, frequently preventing the use of first-line therapy for cancer and jeopardizing patients' treatment outcomes. The present review focuses on immediate hypersensitivity reactions (IHRs) induced by chemotherapeutic agents...
May 2017: Journal of Allergy and Clinical Immunology in Practice
https://www.readbyqxmd.com/read/28477230/a-matched-case-control-comparison-of-hospital-costs-and-outcomes-for-knee-replacement-patients-admitted-postoperatively-to-acute-care-versus-rehabilitation
#19
Brian K Tse, Tessa L Walters, Steven K Howard, T Edward Kim, Stavros G Memtsoudis, Eric C Sun, Alex Kou, Lorrie Graham, Robert King, Edward R Mariano
For select total knee arthroplasty (TKA) patients, we have established an alternative pathway to bypass the acute care surgical ward and directly admit patients from the post-anesthesia care unit to on-campus rehabilitation. We retrospectively examined whether this 'fast track' pathway decreased costs and improved patient outcomes. After reviewing records of consecutive primary unilateral TKA patients over a 15-month period, each patient admitted to rehabilitation was matched with a control admitted to the acute care ward...
May 5, 2017: Journal of Anesthesia
https://www.readbyqxmd.com/read/28473885/prospects-and-limitations-of-antibody-mediated-clearing-of-lipoproteins-from-blood-plasma-prior-to-nanoparticle-tracking-analysis-of-extracellular-vesicles
#20
Morten Mørk, Aase Handberg, Shona Pedersen, Malene M Jørgensen, Rikke Bæk, Morten K Nielsen, Søren R Kristensen
Introduction: Nanoparticle tracking analysis (NTA) enables measurement of extracellular vesicles (EVs) but lacks the ability to distinct between EVs and lipoproteins which are abundantly present in blood plasma. Limitations in ultracentrifugation and size exclusion chromatography applied for EV isolation may result in inadequate EV purification and preservation. In this proof of concept study, we aimed to evaluate the potential of antibody-mediated removal of lipoproteins from plasma prior to extracellular vesicle (EV) analysis by nanoparticle tracking analysis (NTA)...
2017: Journal of Extracellular Vesicles
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