keyword
https://read.qxmd.com/read/38493354/differences-in-pacing-behaviour-between-global-championship-medal-performances-and-world-records-in-men-s-and-women-s-middle-and-long-distance-running-track-events
#1
JOURNAL ARTICLE
Arturo Casado, Luis E Ranieri, Brian Hanley, Carl Foster, Fernando González-Mohíno
The differences in pacing demands between track distance-running championship and meet (e.g., World Record [WR]) races have not been specified yet in the current literature. Therefore, the aim of this study was to determine pacing behaviour differences between WRs and global championship (i.e., World Championships and Olympic Games) medal performances (GCMs) in middle- and long-distance running events. Percentages of mean race section speeds were compared through analysis of variance between men's and women's 169 WRs and 189 GCMs over 800 m, 1500 m, 3000 m steeplechase, 5000 m and 10,000 m...
March 17, 2024: Journal of Sports Sciences
https://read.qxmd.com/read/38492915/reducing-time-to-diagnosis-of-autism-spectrum-disorder-using-an-integrated-community-specialty-care-model-a-retrospective-study
#2
JOURNAL ARTICLE
Jessica M Davis, Molly B Harrington, Flora R Howie, Khaled S Mohammed, Jaclyn A Gunderson
OBJECTIVE: To evaluate a fast-track triage model in an integrated community specialty clinic to reduce the age of diagnosis for patients with autism spectrum disorder (ASD). STUDY DESIGN: A retrospective chart review was performed for patients seen in an integrated community specialty (ICS) pediatric practice using a fast-track screening and triage model. The percentage of ASD diagnoses, age at diagnosis, and time from referral to diagnosis were evaluated. The fast-track triage model was compared with national and statewide estimates of median age of first evaluation and diagnosis...
March 14, 2024: Journal of Pediatrics
https://read.qxmd.com/read/38491519/the-rise-of-big-data-deep-sequencing-driven-computational-methods-are-transforming-the-landscape-of-synthetic-antibody-design
#3
REVIEW
Eugenio Gallo
Synthetic antibodies (Abs) represent a category of artificial proteins capable of closely emulating the functions of natural Abs. Their in vitro production eliminates the need for an immunological response, streamlining the process of Ab discovery, engineering, and development. These artificially engineered Abs offer novel approaches to antigen recognition, paratope site manipulation, and biochemical/biophysical enhancements. As a result, synthetic Abs are fundamentally reshaping conventional methods of Ab production...
March 16, 2024: Journal of Biomedical Science
https://read.qxmd.com/read/38491104/construction-of-environmental-vibration-prediction-model-for-subway-transportation-based-on-machine-learning-algorithm-and-database-technology
#4
JOURNAL ARTICLE
Xilong Zhou
Vibrations generated in the metro transport environment are mainly caused by, vibrations generated by the interaction between the metro and the track during operation. and the change of vibration factors will affect the normal operation of the subway. However, it is difficult to have a model that can achieve the characteristics of high accuracy, fast computing speed and wide range of use in the traditional metro rail transportation environment prediction. Therefore, this research uses database theory and machine learning algorithms to predict the vibration of subway transportation environment...
March 15, 2024: Scientific Reports
https://read.qxmd.com/read/38482114/ruminal-ph-sensing-for-monitoring-volatile-fatty-acid-concentrations-in-response-to-short-term-dietary-disruption
#5
JOURNAL ARTICLE
K Amirault, R Wright, S Sujani, B R Dos Reis, J Osorio, T Fernandes, R R White
The purpose of this study was to investigate the potential of using ruminal pH measurements to track time-series ruminal volatile fatty acid (VFA) concentrations occurring in response to short-term dietary disruption. Four ruminally cannulated dry Holstein dairy cows were individually housed and assigned to 4 treatments in a Latin square design. Treatments differing in forage-to-concentrate (F:C) ratio (100:0 to 55:45) were used because they were expected to result in large differences in VFA concentration, over which the relationships between pH and VFA could be robustly evaluated...
March 2024: JDS Commun
https://read.qxmd.com/read/38480895/self-enhanced-mobility-enables-vortex-pattern-formation-in-living-matter
#6
JOURNAL ARTICLE
Haoran Xu, Yilin Wu
Ranging from subcellular organelle biogenesis to embryo development, the formation of self-organized structures is a hallmark of living systems. Whereas the emergence of ordered spatial patterns in biology is often driven by intricate chemical signalling that coordinates cellular behaviour and differentiation1-4 , purely physical interactions can drive the formation of regular biological patterns such as crystalline vortex arrays in suspensions of spermatozoa5 and bacteria6 . Here we discovered a new route to self-organized pattern formation driven by physical interactions, which creates large-scale regular spatial structures with multiscale ordering...
March 13, 2024: Nature
https://read.qxmd.com/read/38476298/trackplot-a-fast-and-lightweight-r-script-for-epigenomic-enrichment-plots
#7
JOURNAL ARTICLE
Anand Mayakonda, Frank Westermann
MOTIVATION: BigWig files serve as essential inputs in epigenomic data visualization. However, current R packages for visualizing these files are limited, slow, and burdened by numerous dependencies. RESULTS: We introduce  trackplot , a minimal R script designed for the rapid generation of integrative genomics viewer (IGV) style track plots, profile plots, and heatmaps from bigWig files. This script offers speed, owing to its reliance on  bwtool , resulting in performance gains of several magnitudes compared to equivalent packages...
2024: Bioinform Adv
https://read.qxmd.com/read/38473013/exploration-of-preliminary-objective-triage-by-menopause-score-and-ca-125-result-prior-to-accelerating-fast-track-booking-for-suspected-ovarian-cancer-a-role-for-the-pathway-navigator
#8
JOURNAL ARTICLE
Robert Woolas, Lisa Young, Dirk Brinkmann, Francis Gardner, Richard Hadwin, Thomas Woolas, Natalia Povolotskaya
The 28-days-to-diagnosis pathway is the current expected standard of care for women with symptoms of ovarian cancer in the UK. However, the anticipated conversion rate of symptoms to cancer is only 3%, and use of the pathway is increasing. A rapid triage at the moment of receipt of the referral might allow resources to be allocated more appropriately. In secondary care, multidisciplinary teams (MDTs) use the risk of malignancy index (RMI) score, (multiply menopausal status pre = 1 or post = 3 × ultrasound score = 0 - 3 × the CA 125 level), using a score of >200, to triage urgency and management in possible ovarian cancer cases...
March 4, 2024: Diagnostics
https://read.qxmd.com/read/38467170/both-3d-mri-and-ct-are-valuable-for-determination-of-glenoid-and-humeral-bone-loss-in-patients-with-on-and-off-track-shoulder-instability
#9
EDITORIAL
Ryan J Whalen, Matthew T Provencher
Improving the modalities for advanced glenohumeral joint imaging has been an important area to address in the field of orthopaedic surgery. The current gold standard for imaging glenoid and humeral bone loss in patients with shoulder instability, 3D computed tomography (3D-CT), provides high-quality 3D images of bones, but comes with a cost of extra time, additional imaging, due to the need of an additional MRI, and exposure to radiation. 3D magnetic resonance imaging (3D-MRI) is a promising solution that can produce high contrast images depicting both bony structures and soft tissues...
March 9, 2024: Arthroscopy
https://read.qxmd.com/read/38461402/optimised-fast-track-protocols-in-total-knee-arthroplasty-determine-shorter-hospitalisation-time-and-lower-perioperative-postoperative-complications
#10
JOURNAL ARTICLE
Riccardo Compagnoni, Francesco Puglia, Mauro Magnani, Raymond Klumpp, Paolo Ferrua, Filippo Calanna, Carlo Francesco Minoli, Daniele Genco, Alessandra Menon, Pietro Simone Randelli
PURPOSE: This literature review aims to present evidence-based clinical recommendations for the eight most debated topics related to perioperative management in total knee arthroplasty: counselling, prehabilitation, transfusion risk, tranexamic acid, drainage, analgesia, urinary catheter and compression stockings. METHODS: A multidisciplinary team conducted a systematic review on these topics. The study followed the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines for the literature review and result presentation...
March 10, 2024: Knee Surgery, Sports Traumatology, Arthroscopy
https://read.qxmd.com/read/38461367/full-length-single-protein-molecules-tracking-and-counting-in-thin-silicon-channels
#11
JOURNAL ARTICLE
Shilo Ohayon, Liran Taib, Navneet C Verma, Marzia Iarossi, Ivy Bhattacharya, Barak Marom, Diana Huttner, Amit Meller
Emerging single-molecule protein sensing techniques are ushering in a transformative era in biomedical research. Nevertheless, challenges persist in realizing ultra-fast full-length protein sensing, including loss of molecular integrity due to protein fragmentation, biases introduced by antibodies affinity, identification of proteoforms and low throughputs. Here, we introduce a single-molecule method for parallel protein separation and tracking, yielding multi-dimensional and are electrophoretically separated by their mass/charge in custom-designed thin silicon channel with subwavelength height...
March 9, 2024: Advanced Materials
https://read.qxmd.com/read/38456557/millimeter-wave-based-patient-setup-verification-and-motion-tracking-during-radiotherapy
#12
JOURNAL ARTICLE
Max Bressler, Jingxuan Zhu, Joshua Olick-Gibson, Jonathan Haefner, Shuang Zhou, Qinghao Chen, Thomas Mazur, Yao Hao, Paul Carter, Tiezhi Zhang
BACKGROUND: Position verification and motion monitoring are critical for safe and precise radiotherapy (RT). Existing approaches to these tasks based on visible light or x-ray are suboptimal either because they cannot penetrate obstructions to the patient's skin or introduce additional radiation exposure. The low-cost mmWave radar is an ideal solution for these tasks as it can monitor patient position and motion continuously throughout the treatment delivery. PURPOSE: To develop and validate frequency-modulated continuous wave (FMCW) mmWave radars for position verification and motion tracking during RT delivery...
March 8, 2024: Medical Physics
https://read.qxmd.com/read/38455471/estimating-daily-semantic-segmentation-maps-of-classified-ocean-eddies-using-sea-level-anomaly-data-from-along-track-altimetry
#13
JOURNAL ARTICLE
Eike Bolmer, Adili Abulaitijiang, Jürgen Kusche, Ribana Roscher
Mesoscale eddies, which are fast-moving rotating water bodies in the ocean with horizontal scales ranging from 10 km to 100 km and above, are considered to be the weather of the oceans. They are of interest to marine biologists, oceanographers, and geodesists for their impact on water mass, heat, and nutrient transport. Typically, gridded sea level anomaly maps processed from multiple radar altimetry missions are used to detect eddies. However, multi-mission sea level anomaly maps obtained by the operational processors have a lower effective spatiotemporal resolution than their grid spacing and temporal resolution, leading to inaccurate eddy detection...
2024: Frontiers in artificial intelligence
https://read.qxmd.com/read/38455126/onion-allium-cepa-l-and-drought-current-situation-and-perspectives
#14
REVIEW
Oladé Charles Sansan, Vincent Ezin, Mathieu Anatole Tele Ayenan, Ifagbémi Bienvenue Chabi, Hubert Adoukonou-Sagbadja, Aliou Saïdou, Adam Ahanchede
Onions ( Allium cepa L.) are the second most commonly produced and consumed vegetable worldwide due to their economic, nutritional, and medicinal benefits. However, drought hinders vegetative growth, lowers yields and bulb quality, reduces photosynthetic activity, and alters the onion plant's metabolism. This review provides a summary of global research on the impact of drought on onions. It specifically seeks to shed light on aspects that remain unclear and generate research avenues. Relevant scientific articles were sourced from the AGORA database, Web of Science (WoS), and search engines such as Google Scholar, Scopus, MEDLINE/PubMed, and SCImago to achieve this objective...
2024: Scientifica
https://read.qxmd.com/read/38453688/evaluating-novel-biodegradable-polymer-matrix-fertilizers-for-nitrogen-efficient-agriculture
#15
JOURNAL ARTICLE
Torsten Witt, Nicole Robinson, Ana C Palma, Lucas A Cernusak, Steven Pratt, Matthew Redding, Damien J Batstone, Susanne Schmidt, Bronwyn Laycock
Enhanced efficiency fertilizers (EEFs) can reduce nitrogen (N) losses in temperate agriculture but are less effective in the tropics. We aimed to design a new EEF and evaluate their performance in simple-to-complex tests with tropical soils and crops. We melt-extruded urea at different loadings into biodegradable polymer matrix composites using biodegradable polyhydroxyalkanoate (PHA) or polybutylene adipate-co-terephthalate (PBAT) polymers with urea distributed throughout the pellet. These contrast with commercially coated EEF that have a polymer-coated urea core...
March 7, 2024: Journal of Environmental Quality
https://read.qxmd.com/read/38453580/adaptive-recursive-sliding-mode-based-trajectory-tracking-control-for-cable-driven-continuum-robots
#16
JOURNAL ARTICLE
Yanan Qin, Qi Chen, Chengjun Ming
To improve the transient response, accuracy and robustness of trajectory tracking control for cable-driven continuum robots (CDCRs), a recursive integral terminal sliding mode control combined with an adaptive disturbance observer (ADO-RITSMC) is proposed. The recursive integral terminal sliding mode control (RITSMC) guarantees fast transient response and high tracking accuracy with a fast zero convergence of the tracking error without chattering. To attenuate the effect of uncertain dynamics, an adaptive disturbance observer (ADO) is constructed to derive uncertain dynamics...
February 23, 2024: ISA Transactions
https://read.qxmd.com/read/38451275/-unicondylar-knee-arthroplasty-trigger-for-outpatient-arthroplasty
#17
REVIEW
Karina E Bohlen, Ralf Bieger
The combination of a reduction in surgical trauma in unicondylar knee arthroplasty compared to total knee arthroplasty and the introduction of a standardised enhanced recovery concept leads to a pre-, peri- and postoperative improvement in the patient's condition, which results in a reduction of the length of stay in hospital. In healthy, motivated patients, day-case or outpatient surgical treatment is possible under these circumstances.
March 7, 2024: Orthopadie (Heidelb)
https://read.qxmd.com/read/38450288/an-integrated-action-plan-to-fund-and-support-drug-development-for-dup15q-syndrome-a-patient-organization-perspective
#18
JOURNAL ARTICLE
Ryan Rogers-Hammond, Carrie Howell
Maternal 15q11.2-13.1 duplication syndrome, or Dup15q syndrome (Dup15q), is a rare neurodevelopmental disorder affecting as many as 1 in 5000 to 1 in 20,000 children worldwide. Autism and seizures are two of the most commonly observed phenotypes in Dup15q, with intellectual disability, hypotonia, gastrointestinal distress, and substantial fine and gross motor deficits also commonly reported. The community that is now known as the Dup15q Alliance started in 1994 as a small group of families raising children with chromosome 15q duplications...
2024: Ther Adv Rare Dis
https://read.qxmd.com/read/38449802/human-adenovirus-type-3-restores-pharmacologically-inhibited-exosomal-cargo-in-lung-carcinoma-cells
#19
JOURNAL ARTICLE
Ayodeji O Ipinmoroti, Rachana Pandit, Brennetta J Crenshaw, Brian Sims, Qiana L Matthews
Introduction: Drug repurposing is fast growing and becoming an attractive approach for identifying novel targets, such as exosomes for cancer and antiviral therapy. Exosomes are a specialized class of extracellular vesicles that serve as functional mediators in intercellular communication and signaling that are important in normal physiological functions. A continuously growing body of evidence has established a correlation between the abnormal release of exosomes with various viral disease pathologies including cancer...
2024: Frontiers in Pharmacology
https://read.qxmd.com/read/38449430/strategies-to-improve-av-synchrony-in-patients-with-a-micra-av-leadless-pacemaker
#20
JOURNAL ARTICLE
Christophe Garweg, Alexander Breitenstein, Nicolas Clémenty, Carlo De Asmundis, Saverio Iacopino, Jens Brock Johansen, David Sharman, Cathrin Theis, Xavier Viñolas Prat, Stefan Winter, Tobias Reichlin
The second generation of transcatheter pacing systems, called Micra AV, can provide atrio-ventricular (AV) synchronous pacing via a new pacing algorithm relying on sensing mechanical atrial contraction. Several novel programming parameters were introduced to enable AV synchronous pacing, including an A3 and A4 window as well as a conduction and an activity mode switch. In addition to several automated features, manual programming optimization of some of the novel parameters is key to improving AV synchrony...
March 7, 2024: Europace: European Pacing, Arrhythmias, and Cardiac Electrophysiology
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