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https://www.readbyqxmd.com/read/28727158/hplc-fingerprinting-approach-for-raw-material-assesment-and-unit-operation-tracking-for-ivig-production-from-cohn-i-ii-iii-fraction
#1
Sebastijan Peljhan, Tina Jakop, Dunja Šček, Vid Skvarča, Blaž Goričar, Romina Žabar, Nina Mencin
The plasma derived immunoglobulin G (IgG) used either for diagnostic purpose or intravenous application (in form of IVIG) in various medical therapies is certainly gaining more and more attention on annual basis. Different manufacturing processes are used to isolate immunoglobulins from human plasma. However, a quest for alternative paths in IgG isolation not only requires development of the most efficient isolation process, but also a rapid and reliable analytics to track the purification. Fast and reliable fingerprint-based method for characterization of IgG prepared from Cohn I+II+III paste is presented in this paper...
July 20, 2017: Electrophoresis
https://www.readbyqxmd.com/read/28726359/earplugs-during-the-first-night-after-cardiothoracic-surgery-may-improve-a-fast-track-protocol
#2
Johannes Menger, Bernhard Urbanek, Keso Skhirtladze-Dworschak, Viktoria Wolf, Arabella Fischer, Harald Rinösl, Martin Dworschak
BACKGROUND: Sleep deprivation after major surgery is common and associated with worse outcome. Noise is one important reason for sleep fragmentation, which contributes to enhanced morbidity. The purpose of this work was to evaluate the impact of earplugs on patients' sleep quality during their first night after cardiothoracic surgery to eventually improve an existing fast-track concept. METHODS: Sixty-three patients undergoing cardiothoracic surgery eligible for a postoperative fast- track regimen on our cardiothoracic post anaesthesia care unit (C-PACU) were prospectively included...
July 20, 2017: Minerva Anestesiologica
https://www.readbyqxmd.com/read/28722824/local-equilibrium-and-retardation-revisited
#3
Scott K Hansen, Velimir V Vesselinov
In modeling solute transport with mobile-immobile mass transfer (MIMT), it is common to use an advection-dispersion equation (ADE) with a retardation factor, or retarded ADE. This is commonly referred to as making the local equilibrium assumption (LEA). Assuming local equilibrium, Eulerian textbook treatments derive the retarded ADE, ostensibly exactly. However, other authors have presented rigorous mathematical derivations of the dispersive effect of MIMT, applicable even in the case of arbitrarily fast mass transfer...
July 19, 2017: Ground Water
https://www.readbyqxmd.com/read/28718497/review-of-hiv-treatment-progress-gaps-and-challenges-in-the-caribbean-2005-2015
#4
Yitades Gebre, Nikkiah Meoshi Forbes, Abena Peters
Objective: To highlight the current context of the HIV response in the Caribbean and what remains to be addressed to close gaps in HIV treatment and care and end AIDS by 2030. Methods: We reviewed and analyzed reports from peer-reviewed and gray literature for the period of 2005-2015 on HIV treatment progress and gaps in the Caribbean, based on searches done in four bibliographic databases and three organizations' websites and/or libraries. Data were extracted using forms detailing study objectives, thematic areas for HIV care and treatment in the Caribbean, results, and other key information...
December 2016: Revista Panamericana de Salud Pública, Pan American Journal of Public Health
https://www.readbyqxmd.com/read/28714834/adjusting-patients-streaming-initiated-by-a-wait-time-threshold-in-emergency-department-for-minimizing-opportunity-cost
#5
Byungjoon B J Kim, Theodore R Delbridge, Dawn B Kendrick
Purpose Two different systems for streaming patients were considered to improve efficiency measures such as waiting times (WTs) and length of stay (LOS) for a current emergency department (ED). A typical fast track area (FTA) and a fast track with a wait time threshold (FTW) were designed and compared effectiveness measures from the perspective of total opportunity cost of all patients' WTs in the ED. The paper aims to discuss these issues. Design/methodology/approach This retrospective case study used computerized ED patient arrival to discharge time logs (between July 1, 2009 and June 30, 2010) to build computer simulation models for the FTA and fast track with wait time threshold systems...
July 10, 2017: International Journal of Health Care Quality Assurance
https://www.readbyqxmd.com/read/28713249/crispr-cas9-mediated-zebrafish-knock-in-as-a-novel-strategy-to-study-midbrain-hindbrain-boundary-development
#6
Gokul Kesavan, Avinash Chekuru, Anja Machate, Michael Brand
The midbrain-hindbrain boundary (MHB) acts as an organizer and controls the fate of neighboring cells to develop into either mesencephalic (midbrain) or metencephalic (hindbrain) cells by secreting signaling molecules like Wnt1 and Fgf8. The zebrafish is an excellent vertebrate model for studying MHB development due to the ease of gene manipulation and the possibility of following cellular dynamics and morphogenetic processes using live imaging. Currently, only very few reporter and/or Cre-driver lines are available to study gene expression at the MHB, hampering the understanding of MHB development, and traditional transgenic technologies using promoter/enhancer fragments or bacterial artificial chromosome (BAC)-mediated transgenesis often do not faithfully recapitulate endogenous expression patterns...
2017: Frontiers in Neuroanatomy
https://www.readbyqxmd.com/read/28712487/real-time-pi-backstepping-induction-machine-drive-with-efficiency-optimization
#7
Fethi Farhani, Chiheb Ben Regaya, Abderrahmen Zaafouri, Abdelkader Chaari
This paper describes a robust and efficient speed control of a three phase induction machine (IM) subjected to load disturbances. First, a Multiple-Input Multiple-Output (MIMO) PI-Backstepping controller is proposed for a robust and highly accurate tracking of the mechanical speed and rotor flux. Asymptotic stability of the control scheme is proven by Lyapunov Stability Theory. Second, an active online optimization algorithm is used to optimize the efficiency of the drive system. The efficiency improvement approach consists of adjusting the rotor flux with respect to the load torque in order to minimize total losses in the IM...
July 13, 2017: ISA Transactions
https://www.readbyqxmd.com/read/28711332/predictors-of-operating-room-extubation-in-adult-cardiac-surgery
#8
Kathirvel Subramaniam, Diana S DeAndrade, Daniel R Mandell, Andrew D Althouse, Rajan Manmohan, Stephen A Esper, Jeffrey M Varga, Vinay Badhwar
OBJECTIVE: The primary objective of the study was to identify perioperative factors associated with successful immediate extubation in the operating room after adult cardiac surgery. The secondary objective was to derive a simplified predictive scoring system to guide clinicians in operating room extubation. METHODS: All 1518 patients in this retrospective cohort study underwent standardized fast-track cardiac anesthetic protocol during adult cardiac surgery. Perioperative variables between patients who had successful extubation in the operating room versus in the intensive care unit were retrospectively analyzed using both univariate and multivariable logistic regression analyses...
June 13, 2017: Journal of Thoracic and Cardiovascular Surgery
https://www.readbyqxmd.com/read/28706083/wealth-related-inequality-in-early-uptake-of-hiv-testing-among-pregnant-women-an-analysis-of-data-from-a-national-cross-sectional-survey-south-africa
#9
Nobubelo Kwanele Ngandu, Carine Van Malderen, Ameena Goga, Niko Speybroeck
OBJECTIVES: Wealth-related inequality across the South African antenatal HIV care cascade has not been considered in detail as a potential hindrance to eliminating mother-to-child HIV transmission (EMTCT). We aimed to measure wealth-related inequality in early (before enrolling into antenatal care) uptake of HIV testing and identify the contributing determinants. DESIGN: Cross-sectional survey. SETTINGS: South African primary public health facilities in 2012...
July 12, 2017: BMJ Open
https://www.readbyqxmd.com/read/28702051/random-forest-based-approach-for-maximum-power-point-tracking-of-photovoltaic-systems-operating-under-actual-environmental-conditions
#10
Hussain Shareef, Ammar Hussein Mutlag, Azah Mohamed
Many maximum power point tracking (MPPT) algorithms have been developed in recent years to maximize the produced PV energy. These algorithms are not sufficiently robust because of fast-changing environmental conditions, efficiency, accuracy at steady-state value, and dynamics of the tracking algorithm. Thus, this paper proposes a new random forest (RF) model to improve MPPT performance. The RF model has the ability to capture the nonlinear association of patterns between predictors, such as irradiance and temperature, to determine accurate maximum power point...
2017: Computational Intelligence and Neuroscience
https://www.readbyqxmd.com/read/28700137/dual-led-based-multichannel-microscopy-for-whole-slide-multiplane-multispectral-and-phase-imaging
#11
Jun Liao, Zhe Wang, Zibang Zhang, Zichao Bian, Kaikai Guo, Aparna Nambiar, Yutong Jiang, Shaowei Jiang, Jingang Zhong, Michael Choma, Guoan Zheng
We report the development of a multichannel microscopy for whole-slide multiplane, multispectral, and phase imaging. We use trinocular heads to split the beam path into 6 independent channels and employ a camera array for parallel data acquisition, achieving a maximum data throughput of ~1 gigapixel per second. To perform single-frame rapid autofocusing, we place two near-infrared LEDs at the back focal plane of the condenser lens to illuminate the sample from two different incident angles. A hot mirror is used to direct the near-infrared light to an autofocusing camera...
July 12, 2017: Journal of Biophotonics
https://www.readbyqxmd.com/read/28694229/motor-expertise-modulates-neural-oscillations-and-temporal-dynamics-of-cognitive-control
#12
Chun-Hao Wang, Cheng-Ta Yang, David Moreau, Neil G Muggleton
The field of motor expertise in athletes has recently been receiving increasing levels of investigation. However, there has been less investigation of how dynamic changes in behavior and in neural activity as a result of sporting participation might result in superiority for athletes in domain-general cognition. We used a flanker task to investigate conflict-related behavioral measures, such as mean reaction time (RT) and RT variability, in conjunction with electroencephalographic (EEG) measures, including N2d, theta activity power, and inter-trial phase coherence (ITPC)...
July 8, 2017: NeuroImage
https://www.readbyqxmd.com/read/28693471/spatial-pattern-analysis-of-nuclear-migration-in-remodelled-muscles-during-drosophila-metamorphosis
#13
Kuleesha, Lin Feng, Martin Wasser
BACKGROUND: Many human muscle wasting diseases are associated with abnormal nuclear localization. During metamorphosis in Drosophila melanogaster, multi-nucleated larval dorsal abdominal muscles either undergo cell death or are remodeled to temporary adult muscles. Muscle remodeling is associated with anti-polar nuclear migration and atrophy during early pupation followed by polar migration and muscle growth during late pupation. Muscle remodeling is a useful model to study genes involved in myonuclear migration...
July 10, 2017: BMC Bioinformatics
https://www.readbyqxmd.com/read/28691536/mabp1-for-the-treatment-of-colorectal-cancer
#14
Geraldine O'Sullivan Coyne, Mauricio Burotto
Inflammation is an established process in colorectal cancer development and a hallmark of progression, and pro-inflammatory cytokines have been implicated in the morbidity and functional compromise associated with malignancy. MABp1, described as a first-in-class true human antibody against interleukin-1α, has undergone clinical trial evaluation in a number of indications, recently completing late phase clinical trial testing under Fast Track designation for cancer anorexia-cachexia syndrome in colorectal cancer patients...
July 10, 2017: Expert Opinion on Biological Therapy
https://www.readbyqxmd.com/read/28690715/a-novel-aerodynamic-sizing-method-for-pharmaceutical-aerosols-using-image-based-analysis-of-settling-velocities
#15
Rami Fishler, Josué Sznitman
This article discusses a novel method to estimate aerodynamic particle size distributions (APSDs) of pharmaceutical aerosols through direct measurement of particle settling velocities using image-based analysis and particle tracking techniques. This simple, optical method provides accurate and fast measurements (approximately 1 minute) with few sources of bias due to specific device design choices or operation conditions. A proof-of-concept for the method is demonstrated by measuring APSDs for widely available commercial dry powder inhalers (DPIs), then comparing the results with previously published data from cascade impactors (CIs) and the Aerodynamic Particle Sizer (APS)...
June 2017: Inhalation
https://www.readbyqxmd.com/read/28689784/gedos-secot-consensus-on-the-care-process-of-patients-with-knee-osteoarthritis-and-arthoplasty
#16
M A Ruiz Iban, A Tejedor, E Gil Garay, C Revenga, J C Hermosa, J Montfort, M J Peña, J M López Millán, A Montero Matamala, A Capa Grasa, M J Navarro, M Gobbo, E Loza
OBJECTIVE: To develop recommendations on the evaluation and management procedure in patients undergoing total knee replacement based on best evidence and the experience of a panel of experts. METHODS: A multidisciplinary group of 12 experts was selected that defined the scope, users and the document parts. Three systematic reviews were performed in patients undergoing knee replacement: (i)efficacy and safety of fast-tracks; (ii)efficacy and safety of cognitive interventions in patients with catastrophic pain, and (iii) efficacy and safety of acute post-surgical pain management on post-surgical outcomes...
July 6, 2017: Revista Española de Cirugía Ortopédica y Traumatología
https://www.readbyqxmd.com/read/28685751/meniscus-assisted-solution-printing-of-large-grained-perovskite-films-for-high-efficiency-solar-cells
#17
Ming He, Bo Li, Xun Cui, Beibei Jiang, Yanjie He, Yihuang Chen, Daniel O'Neil, Paul Szymanski, Mostafa A Ei-Sayed, Jinsong Huang, Zhiqun Lin
Control over morphology and crystallinity of metal halide perovskite films is of key importance to enable high-performance optoelectronics. However, this remains particularly challenging for solution-printed devices due to the complex crystallization kinetics of semiconductor materials within dynamic flow of inks. Here we report a simple yet effective meniscus-assisted solution printing (MASP) strategy to yield large-grained dense perovskite film with good crystallization and preferred orientation. Intriguingly, the outward convective flow triggered by fast solvent evaporation at the edge of the meniscus ink imparts the transport of perovskite solutes, thus facilitating the growth of micrometre-scale perovskite grains...
July 7, 2017: Nature Communications
https://www.readbyqxmd.com/read/28685445/a-new-method-based-on-graphics-processing-units-for-fast-near-infrared-optical-tomography
#18
Jingjing Jiang, Linda Ahnen, Alexander Kalyanov, Scott Lindner, Martin Wolf, Salvador Sanchez Majos
The accuracy of images obtained by Diffuse Optical Tomography (DOT) could be substantially increased by the newly developed time resolved (TR) cameras. These devices result in unprecedented data volumes, which present a challenge to conventional image reconstruction techniques. In addition, many clinical applications require taking photons in air regions like the trachea into account, where the diffusion model fails. Image reconstruction techniques based on photon tracking are mandatory in those cases but have not been implemented so far due to computing demands...
2017: Advances in Experimental Medicine and Biology
https://www.readbyqxmd.com/read/28683873/fireworks-fast-track-and-throughput-initiative
#19
Tracy McDonald, Jennifer Parks, Karla Oberle
No abstract text is available yet for this article.
July 2017: Journal of Emergency Nursing: JEN: Official Publication of the Emergency Department Nurses Association
https://www.readbyqxmd.com/read/28682892/in-patients-undergoing-fast-track-total-knee-arthroplasty-addition-of-buprenorphine-to-a-femoral-nerve-block-has-no-clinical-advantage-a-prospective-double-blinded-randomized-placebo-controlled-trial
#20
RANDOMIZED CONTROLLED TRIAL
Rienk van Beek, Harry J Zonneveldt, Tjeerd van der Ploeg, Jeroen Steens, Phillip Lirk, Marcus W Hollmann
BACKGROUND: Several adjuvants have been proposed to prolong the effect of peripheral nerve blocks, one of which is buprenorphine. In this randomized double blinded placebo controlled trial we studied whether the addition of buprenorphine to a femoral nerve block prolongs analgesia in patients undergoing total knee arthroplasty in a fast track surgery protocol. METHODS: The treatment group (B) was given an ultrasound-guided femoral nerve block with ropivacaine 0...
July 2017: Medicine (Baltimore)
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