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Transdermal pain cream

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https://www.readbyqxmd.com/read/27757050/new-topical-treatment-of-vulvodynia-based-on-the-pathogenetic-role-of-cross-talk-between-nociceptors-immunocompetent-cells-and-epithelial-cells
#1
J M Keppel Hesselink, D J Kopsky, N Sajben
Topical treatments of localized neuropathic pain syndromes in general are mostly neglected, mainly due to the fact that most pain physicians expect that a topical formulation needs to result in a transdermal delivery of the active compounds. On the basis of the practical experience, this study brings forth a new, somewhat neglected element of the vulvodynia pathogenesis: the cross talk between the nerve endings of nociceptors, the adjacent immunocompetent cells, and vaginal epithelial cells. Insight into this cross talk during a pathogenic condition supports the treatment of vulvodynia with topical (compounded) creams...
2016: Journal of Pain Research
https://www.readbyqxmd.com/read/27419471/clinical-effect-of-ablative-fractional-laser-assisted-topical-anesthesia-on-human-skin-a-randomized-pilot-study
#2
Tian Tian, Yaojia Luo, Tianling Jiang, Yuxi Dong, Aijiao Yu, Hongduo Chen, Xinghua Gao, Yuanhong Li
BACKGROUND AND OBJECTIVES: Most topical medications need a long time to penetrate into the skin owing to the stratum corneum (SC) barrier. The fractional erbium-doped yttrium aluminum garnet (Er:YAG) laser has the ability to disrupt the SC and assist in the delivery of topical drugs to penetrate into the skin. This study was intended to determine whether pretreatment with a painless fractional Er:YAG laser could assist transdermal delivery of topical anesthesia. MATERIALS AND METHODS: In 22 healthy female subjects, three 4 × 3 cm regions on the right forearm were randomized to: fractional laser plus topical lidocaine cream (Group LaserAnes), sham irradiation plus topical anesthesia (Group Anes), and sham irradiation plus sham anesthesia (Group Con)...
August 5, 2016: Journal of Cosmetic and Laser Therapy: Official Publication of the European Society for Laser Dermatology
https://www.readbyqxmd.com/read/27375183/plum-blossom-needling-promoted-ppix-fluorescence-intensity-from-5-aminolevulinic-acid-in-porcine-skin-model-and-patients-with-actnic-keratosis
#3
Jia Chen, Yunfeng Zhang, Peiru Wang, Bo Wang, Guolong Zhang, Xiuli Wang
BACKGROUND AND OBJECTIVES: Plum-blossom needling might enhance transdermal penetration of topically applied drugs by creating vertical channels. The purpose of this study was to evaluate drug delivery assisted by plum-blossom needling comparing with CO2 laser ablative fractional resurfacing (AFR) using 5-aminolevulinic acid (5-ALA), a porphyrin precursor, as a test drug. MATERIALS AND METHODS: Ex vivo porcine skin was treated with plum-blossom needle(HWATO, Suzhou medical supplies factory Co...
September 2016: Photodiagnosis and Photodynamic Therapy
https://www.readbyqxmd.com/read/27312538/does-menopausal-hormone-therapy-mht-exercise-or-a-combination-of-both-improve-pain-and-function-in-post-menopausal-women-with-greater-trochanteric-pain-syndrome-gtps-a-randomised-controlled-trial
#4
Charlotte Ganderton, Adam Semciw, Jill Cook, Tania Pizzari
BACKGROUND: Greater trochanteric pain syndrome (GTPS) is pathology in the gluteus medius and minimus tendons and trochanteric bursa that causes debilitating tendon pain and dysfunction, particularly in post-menopausal women. Limited evidence in clinical studies suggests hormone changes after menopause may have a negative effect on tendon. This protocol describes a randomised controlled trial comparing the effectiveness of menopausal hormone therapy (MHT) and exercise therapy in reducing pain and dysfunction associated with GTPS in post-menopausal women...
2016: BMC Women's Health
https://www.readbyqxmd.com/read/26689066/-transdermal-local-anesthetics
#5
Kazuo Hanaoka, Hideko Arita, Masaki Nagase, Takashi Suzuki, Sestsuro Ogawa
Taking EMLA cream and Penles tape 18 mg as examples, this article describes the conditions for skin penetration of topical anesthetics, with their onset time of action, duration of effect and a precautions for their use. EMLA cream is a unique cream for topical anesthesia which is the eutectic mixture of lidocaine and propitocaine to increase skin penetration. The safety study demonstrated that blood concentrations of active ingredients of EMLA cream were below toxic levels. EMLA cream, with confirmed high skin penetrability and safety, should be used for pain reduction of various treatments for many diseases...
November 2015: Masui. the Japanese Journal of Anesthesiology
https://www.readbyqxmd.com/read/26685497/analgesic-efficacy-and-transdermal-penetration-of-topical-gabapentin-creams-finding-an-optimal-dose-and-pre-treatment-time
#6
Allie Heustess, Shuler Spigener, Sarah Sweitzer, Alfonso Romero-Sandoval, Scott Asbill
Many patients with chronic neuropathic pain continue to suffer despite traditional pharmacotherapy. As a result, pharmacists commonly compound gabapentin into creams, gels, and ointments as an alternative treatment option. In this study, various concentrations (1%, 5%, and 10%) of topical gabapentin compounded in Lipoderm were applied at various pre-treatment times (30 minutes, 1 hour, and 4 hours) to investigate what gabapentin concentration and pre-treatment time best attenuates formalin-induced nociceptive behaviors in a rodent model...
March 2015: International Journal of Pharmaceutical Compounding
https://www.readbyqxmd.com/read/25859821/retrospective-study-on-the-analgesic-activity-of-a-topical-tt-ctac-cream-in-patients-with-diabetic-neuropathy-and-other-chronic-pain-conditions
#7
John C Somberg, Janos Molnar
Treatment of chronic pain in diabetic neuropathy or neuropathic pain of other origins is challenging. Compounded topical formulations have evolved as potential treatment options. The objective of this retrospective study was to evaluate the efficacy of a compounded topical cream (Transdermal Therapeutics). Two versions of TT-CTAC cream were evaluated: cream 6B and cream 7B. Both creams contain ketamine (10%), baclofen (2%), gabapentin (6%), amitriptyline (4%), bupivacaine (2%), and clonidine (0.2%). Additionally, one cream (7B) contains nifedipine (2%)...
May 2015: American Journal of Therapeutics
https://www.readbyqxmd.com/read/25508635/compounded-pain-formulations-what-is-the-evidence
#8
Scott Asbill, Sarah M Sweitzer, Shuler Spigener, Alfonso Romero-Sandoval
Pain syndromes are among the most widespread, costly, and debilitating of all neurological disorders. The number of patients living with chronic pain is expected to increase with the aging population and with the rise in obesity and diabetes across the nation. This type of pain is often insensitive to the traditional pain pharmacopeia or surgical intervention. Over the last 10 years the number of prescriptions that have been compounded by pharmacists has increased dramatically. There are a number of drugs in the area of pain management that have been formulated and compounded by pharmacists to treat conditions such as diabetic neuropathy, fibromyalgia, postherpetic neuralgia, joint pain, arthritis, and a variety of other conditions...
July 2014: International Journal of Pharmaceutical Compounding
https://www.readbyqxmd.com/read/25474856/compounded-pain-formulations-what-is-the-evidence
#9
REVIEW
Scott Asbill, Sarah M Sweitzer, Shuler Spigener, Alfonso Romero-Sandoval
Pain syndromes are among the most widespread, costly, and debilitating of all neurological disorders. The number of patients living with chronic pain is expected to increase with the aging population and with the rise in obesity and diabetes across the nation. This type of pain is often insensitive to the traditional pain pharmacopeia or surgical intervention. Over the last 10 years the number of prescriptions that have been compounded by pharmacists has increased dramatically. There are a number of drugs in the area of pain management that have been formulated and compounded by pharmacists to treat conditions such as diabetic neuropathy, fibromyalgia, postherpetic neuralgia, joint pain, arthritis, and a variety of other conditions...
July 2014: International Journal of Pharmaceutical Compounding
https://www.readbyqxmd.com/read/25069571/high-dose-capsaicin-for-the-treatment-of-neuropathic-pain-what-we-know-and-what-we-need-to-know
#10
REVIEW
Nurcan Üçeyler, Claudia Sommer
Neuropathic pain is a frequent and disabling condition with diverse underlying etiologies and is often difficult to treat. Systemic drug treatment is often limited in efficacy. Furthermore, adverse effects may be a limiting factor when trying to reach the necessary dose. Analgesics that can be applied topically have the potential to largely overcome this problem. They may be of particular advantage in localized neuropathic pain syndromes such as postherpetic neuralgia or small fiber neuropathy. Capsaicin, the pungent component of chili peppers, is a natural ligand of the transient receptor potential vanilloid 1 channel and has long been used as topically applicable cream with concentrations of 0...
December 2014: Pain and Therapy
https://www.readbyqxmd.com/read/24711894/meloxicam-transdermal-delivery-effect-of-eutectic-point-on-the-rate-and-extent-of-skin-permeation
#11
Soliman Mohammadi-Samani, Gholamhossein Yousefi, Farhad Mohammadi, Fatemeh Ahmadi
OBJECTIVE(S): Drug delivery through the skin can transfer therapeutic levels of drugs for pharmacological effects. Analgesics such as NSAIDs have gastrointestinal side effects and topical dosage forms of these drugs are mainly preferred, especially for local pains. Meloxicam is one of NSAIDs with no topical form in the market. In this research, we attempted to quantify the skin permeation of a meloxicam topical preparation and to show how permeation would be increased by using thymol as an enhancer...
February 2014: Iranian Journal of Basic Medical Sciences
https://www.readbyqxmd.com/read/23908302/topical-lidocaine-enhanced-by-laser-pretreatment-a-safe-and-effective-method-of-analgesia-for-facial-rejuvenation
#12
RANDOMIZED CONTROLLED TRIAL
Georgette Oni, Yvonne Rasko, Jeffrey Kenkel
BACKGROUND: Injectable forms of anesthesia for nonsurgical facial rejuvenation, although efficacious, are uncomfortable for the patient. Preclinical studies have demonstrated that laser pretreatment at low energies enhances absorption of topical lidocaine. OBJECTIVES: The authors assess the safety and efficacy of laser-assisted transdermal delivery of topical anesthetic. METHOD: Ten patients were split into 2 groups (A and B). All patients received 15 g of BLT (20% benzocaine, 6% lidocaine, and 4% tetracaine triple anesthetic cream) for 20 minutes with no occlusion...
August 1, 2013: Aesthetic Surgery Journal
https://www.readbyqxmd.com/read/22833771/transdermal-lidocaine-and-ketamine-for-neuropathic-pain-a-study-of-effectiveness-and-tolerability
#13
Emily Tam, Andrea D Furlan
BACKGROUND: Acute neuropathic pain is a common disorder. Transdermal cream could be an alternative to oral medications. OBJECTIVE: To evaluate the effectiveness and tolerability of transdermal Lidocaine and Ketamine for acute neuropathic pain. STUDY DESIGN: Retrospective chart review SETTING: University-affiliated outpatient Physiatry clinic METHODS: ARTICIPANTS: neuropathic pain with a prescription of a transdermal cream containing Lidocaine and Ketamine...
2012: Open Neurology Journal
https://www.readbyqxmd.com/read/22565145/transdermal-behaviors-comparisons-among-evodia-rutaecarpa-extracts-with-different-purity-of-evodiamine-and-rutaecarpine-and-the-effect-of-topical-formulation-in-vivo
#14
COMPARATIVE STUDY
Fei Chen, Su Li, Dai Li, Jin-Song Ding
AIM: Evodiamine (EVO) and rutaecapine (RUT), the major active components from Evodia rutaecarpa extract (EE), are recognized as a depended analgesic agent. This study was designed to investigate the effect of purity and chemical enhancers on the transdermal behavior of EVO and RUT, and the pharmacological effect of their topical cream in vivo. MATERIAL AND METHODS: Transdermal delivery across a full thickness pig abdominal skin was detected in vitro by Franz-type diffusion cell, with HPLC for quantification of the permeation of EVO and RUT...
July 2012: Fitoterapia
https://www.readbyqxmd.com/read/22168832/the-effect-of-formulation-vehicles-on-the-in-vitro-percutaneous-permeation-of-ibuprofen
#15
Jessica Stahl, Mareike Wohlert, Manfred Kietzmann
BACKGROUND: The transdermal application of substances represents an elegant approach to overcome side effects related to injections or oral treatment. Due to benefits like a constant plasma level, no pain during application and a simple therapeutic regime, the optimization of formulations for transdermal drug delivery has gained interest in the last decades. Ibuprofen is a non-steroidal anti-inflammatory compound which is nowadays often used transdermally. The objective of this work was to conduct a study on the effect of different 5% ibuprofen containing formulations (Ibutop® cream, Ibutop® gel, and ibuprofen solution in phosphate buffered saline) on the in vitro-percutaneous permeation of ibuprofen through skin to emphasise the importance of the formulation on percutaneous permeation and skin reservoir...
2011: BMC Pharmacology
https://www.readbyqxmd.com/read/21904096/review-of-current-guidelines-on-the-care-of-postherpetic-neuralgia
#16
REVIEW
Charles E Argoff
An unfortunate minority of patients with acute herpes zoster (AHZ) experience pain beyond the typical 4-week duration, and roughly 10% develop the distressing complication of postherpetic neuralgia (PHN), often defined as pain persisting for > 4 months after the onset of the rash. Elderly patients are at increased risk of PHN. The pathophysiology of PHN is complex, likely involving both peripheral and central processes. This complexity may create opportunities for pharmacologic interventions with multiple differing mechanisms of action...
September 2011: Postgraduate Medicine
https://www.readbyqxmd.com/read/21364497/prolonged-cutaneous-analgesia-with-transdermal-application-of-amitriptyline-and-capsaicin
#17
COMPARATIVE STUDY
Anna Christin Colvin, Chi-Fei Wang, Mieke A Soens, Aya A Mitani, Gary Strichartz, Peter Gerner
BACKGROUND AND OBJECTIVES: Capsaicin selectively binds to TRPV1, the vanilloid subtype 1 of the superfamily of transient receptor potential ion channels, which is highly expressed in pain-transmitting C fibers. Recent reports have demonstrated that the coadministration of capsaicin with a local anesthetic (LA) at the rat sciatic nerve elicits a prolonged nociceptive-selective nerve block, suggesting that activation of the TRPV1 receptor may allow LAs to enter the nerve through the TRPV1 pore...
May 2011: Regional Anesthesia and Pain Medicine
https://www.readbyqxmd.com/read/20858066/transdermal-permeation-of-novel-n-acetyl-glucosamine-nsaids-mutual-prodrugs
#18
Bridg'ette Israel, Solomon T Garner, Mohan Thakare, Deborah Elder, Trinia Abney, Parastoo Azadi, J Warren Beach, James C Price, Hisham Ahmed, Anthony C Capomacchia
The current investigation reports skin permeation of three novel mutual prodrugs (MP) which couple n-acetyl-glucosamine with an NSAID, either ketoprofen or ibuprofen. They were evaluated for transdermal permeation using shed snakeskin, and to our knowledge represent the first MPs synthesized for this purpose, although they also could be used for subcutaneous delivery. MPs are defined as two active drug compounds usually connected by an ester linkage. Glucosamine administration has been linked to damaged cartilage repair, and pain relief in joints afflicted with osteoarthritis...
January 2012: Pharmaceutical Development and Technology
https://www.readbyqxmd.com/read/19163212/thermal-effect-of-sonophoresis-for-accelerating-the-analgesic-effect-of-local-anesthetics-on-rat-tail-nerve
#19
Yi-Hui Wu, Wen-Shiang Chen, Jer-Junn Luh, Fok-Ching Chong
Sonophoresis is an ultrasound transdermal drugs delivery system. The eutectic mixture of local anesthetics (EMLA) has been used clinically for anesthesia but requires at least one hour to take effect and lacks of analgesia's objective assessment. We proposed that sonophoresis could reduce the duration of EMLA analgesia effect onset and be assessed by sensory conduction studies. Thirty Wistar adult rats were randomized into normal, control, ultrasound-, and heat-treatment groups. Normal group was received no EMLA cream or ultrasound and heat treatment...
2008: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/18978008/pharmacologic-approaches-for-reducing-venous-access-pain-in-children
#20
REVIEW
William T Zempsky
A variety of pharmacologic options are available to clinicians who want to provide effective and safe topical local anesthesia to children undergoing venous access procedures. These options can be distinguished on the basis of how they deliver active drug through the impermeable outer layer of skin, the stratum corneum, to pain receptors located in the dermis and epidermis. Three general methodologies are typically used to bypass the stratum corneum: direct injection of local anesthetics, usually via a small-gauge hypodermic syringe; passive diffusion from topical creams or gels; and active needle-free drug strategies that enhance the rate of drug passage into the dermis and epidermis...
November 2008: Pediatrics
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