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Compounding pharmacy

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https://www.readbyqxmd.com/read/28628866/anticancer-drugs-consumption-trends-in-spain-prediction-of-environmental-concentrations-and-potential-risks
#1
Helena Franquet-Griell, Cristian Gómez-Canela, Francesc Ventura, Silvia Lacorte
This study presents the occurrence and impact of 78 anticancer drugs in Spanish river basins based on consumption data in pharmacies during the period 2010-2015 and calculation of the predicted environmental concentrations (PEC). The total consumption of anticancer drugs in Spanish pharmacies was of 23.4 tons in 2015, being mycophenolic acid and hydroxycarbamide the drugs with the highest prescription. Their PECs in river at national scale were up to 80 ng/L. However, the use of different dilution factors revealed major differences between hydrographic basins, and PECriver rose up to 68,014 ng/L in highly populated rivers with low flows...
June 16, 2017: Environmental Pollution
https://www.readbyqxmd.com/read/28617905/incidence-of-presumed-silicone-oil-droplets-in-the-vitreous-cavity-after-intravitreal-bevacizumab-injection-with-insulin-syringes
#2
Rahul N Khurana, Louis K Chang, Travis C Porco
Importance: Intravitreal bevacizumab is a frequently used antivascular endothelial growth factor medication in the United States, but its off-label use is associated with risks associated with the compounding preparation. Objective: To determine the incidence of presumed silicone oil droplets after intravitreal bevacizumab was prepared in insulin syringes by a compounding pharmacy. Design, Setting, and Participants: A retrospective review was conducted of 60 patients who experienced intravitreal silicone oil droplets in the eye after intravitreal bevacizumab injections from a single specialist practice from October 1, 2015, to November 30, 2016...
June 15, 2017: JAMA Ophthalmology
https://www.readbyqxmd.com/read/28591284/quality-of-bevacizumab-avastin%C3%A2-repacked-in-single-use-glass-vials-for-intravitreal-administration
#3
Michelle A A Sugimoto, Vicente de Paulo Coelho Peixoto de Toledo, Mariem Rodrigues Ribeiro Cunha, Virginia M Carregal, Rodrigo Jorge, Pedro Leão, Sílvia Ligorio Fialho, Armando Silva-Cunha
Purpose: Avastin® (bevacizumab) is an anti-vascular endothelial growth factor (VEGF) monoclonal antibody given as an off-label drug by intravitreal administration for treatment of ocular diseases. The drug's clinical application and its cost-benefit profile has generated demand for its division into single-use vials to meet the low volume and low-cost doses necessary for intraocular administration. However, the safety of compounding the drug in single-use vials is still under discussion...
March 2017: Arquivos Brasileiros de Oftalmologia
https://www.readbyqxmd.com/read/28576960/compounding-pharmacists-provide-customized-care
#4
Jennifer Burch
Compounding is the creation of a pharmaceutical preparation by a licensed pharmacist to meet the unique needs of an individual patient when commercially available drugs do not meet those needs. For hundreds of years, compounding was the traditional practice of pharmacy. Today's advanced practice of compounding provides health care practitioners customized options for unique patients or for hard to treat conditions.
May 2017: North Carolina Medical Journal
https://www.readbyqxmd.com/read/28557783/basics-of-compounding-3d-printing-pharmacy-applications-part-2
#5
Loyd V Allen
3D printing is a standard tool in the automotive, aerospace, and consumer goods in industry and is gaining traction in pharmaceutical manufacturing, which has introduced a new element into dosage-form development. This article, which represents part 2 of a 3-part article on the topic of 3D printing, discusses the different technologies available for 3D printing.
May 2017: International Journal of Pharmaceutical Compounding
https://www.readbyqxmd.com/read/28557780/microbiologic-testing-for-503a-sterile-compounding-pharmacies
#6
William Mixon, Abby Roth
Compounding pharmacists must ensure that the sterile preparations they dispense are free of microbiologic contamination. Working in a cleanroom under controlled conditions (proper differential air pressure, temperature, and humidity; acceptable levels of viable and nonviable airborne particles and surface counts, etc.) and testing the efficacy of cleaning and disinfecting practices via environmental monitoring (viable-air and surface testing, glove-fingertip-thumb testing, etc.) are essential to preparing contamination-free medications...
May 2017: International Journal of Pharmaceutical Compounding
https://www.readbyqxmd.com/read/28557779/adventures-in-the-environmental-world-and-environmental-microbiology-sampling-of-air-for-pharmaceutical-sterile-compounding
#7
Roberto Ligugnana
Chapter <797> issued by the United States Pharmacopeial Convention, Inc. is the standard for sterile compounding. It is designed to reduce the number of patient infections due to contaminated pharmaceutical preparation. This regulation applies to all staff who prepare compounded sterile preparations and all places where they are produced, including hospitals, clinics, pharmacies, and physician's offices. This article provides the history of environmental microbiology and provides a discussion on environmental microbiology sampling of air for pharmaceutical sterile compounding...
May 2017: International Journal of Pharmaceutical Compounding
https://www.readbyqxmd.com/read/28553184/initial-experience-in-the-use-of-technetium-99-metastable-hydroxymethylene-diphosphonate-as-an-alternative-ventilation-agent-during-periods-of-interim-shortage
#8
Colin Raymond Young, Kalpna Prasad
Sporadic supply interruptions of select radiopharmaceuticals on the global market require consideration of alternative agents to support continuity of essential nuclear medicine examinations. During an acute shortage of Xenon-133 and technetium-99 metastable (Tc-99m) diethylene-triamine-pentaacetate (DTPA), our institution used aerosolized Tc-99m hydroxymethylene diphosphonate (HDP), a radiopharmaceutical traditionally used in bone scintigraphy, in lieu of traditional ventilation agents, for two cases of suspected pulmonary embolism...
April 2017: World Journal of Nuclear Medicine
https://www.readbyqxmd.com/read/28539726/development-and-validation-of-a-simultaneous-rp-hplcuv-dad-method-for-determination-of-polyphenols-in-gels-containing-s-terebinthifolius-raddi-anacardiaceae
#9
Melina G Carvalho, Cícero F S Aragão, Fernanda N Raffin, Túlio F A de L Moura
Topical gels containing extracts of Schinus terebinthifolius have been used to treat bacterial vaginosis. It has been reported that this species has antimicrobial, anti-inflammatory and anti-ulcerogenic properties, which can be attributed to the presence of phenolic compounds. In this work, a sensitive and selective reversed-phase HPLC-UV/DAD method for the simultaneous assay of six polyphenols that could be present in S. terebinthifolius was developed. The method was shown to be accurate and precise. Peak purity and similarity index both exceeded 0...
April 2017: Pharmacognosy Magazine
https://www.readbyqxmd.com/read/28512133/quality-of-compounded-hydrocortisone-capsules-used-in-the-treatment-of-children
#10
Uta Neumann, Daniela Burau, Sarah Spielmann, Martin Whitaker, Richard J Ross, Charlotte Kloft, Oliver Blankenstein
Objectives: Due to the lack of paediatric licensed formulations, children are often treated with individualized pharmacy-compounded adult medication. An international web-based survey about the types of medication in children with adrenal insufficiency (AI) revealed that the majority of paediatric physicians are using pharmacy-compounded medication to treat children with AI. Observations of loss of therapy control in children with congenital adrenal hyperplasia with compounded hydrocortisone capsules and regained control after prescribing a new hydrocortisone batch led to this "real world" evaluation of pharmacy-compounded paediatric hydrocortisone capsules...
May 16, 2017: European Journal of Endocrinology
https://www.readbyqxmd.com/read/28497135/unscrambling-micro-solvation-of-cooh-and-nh-groups-in-neat-dimethyl-sulfoxide-insights-from-1-h-nmr-spectroscopy-and-computational-studies
#11
Panteleimon G Takis, Konstantinos D Papavasileiou, Loukas D Peristeras, Georgios C Boulougouris, Vasilios S Melissas, Anastassios N Troganis
Dimethyl sulfoxide (DMSO) has a significant, multi-faceted role in medicine, pharmacy, and biology as well as in biophysical chemistry and catalysis. Its physical properties and impact on biomolecular structures still attract major scientific interest, especially the interactions of DMSO with biomolecular functional groups. In the present study, we shed light on the "isolated" carboxylic (-COOH) and amide (-NH) interactions in neat DMSO via(1)H NMR studies along with extensive theoretical approaches, i.e. molecular dynamics (MD) simulations, density functional theory (DFT), and ab initio calculations, applied on model compounds (i...
May 31, 2017: Physical Chemistry Chemical Physics: PCCP
https://www.readbyqxmd.com/read/28454501/carry-over-of-antineoplastic-drug-contamination-in-dutch-hospital-pharmacies
#12
M Crul, K Simons-Sanders
Background To prevent occupational exposure of hospital staff to cytostatics, a mandatory national guideline describing a set of safety measures was issued in the Netherlands in 2004. The guideline includes, among other directives, obligatory annual wipe testing to assess the efficacy of the local cleaning protocol. Full implementation of this guideline was executed in all Dutch hospital pharmacies over the next couple of years. Objective We aimed to investigate the effect of the national guideline on contamination levels, and specifically on the phenomenon of carry-over of traces of antineoplastic drugs through contact with surfaces, since this is a potential route of exposure...
January 1, 2017: Journal of Oncology Pharmacy Practice
https://www.readbyqxmd.com/read/28453716/inflated-medicine-prices-in-vietnam-a-qualitative-study
#13
Tuan Anh Nguyen, Rosemary Knight, Andrea Mant, Husna Razee, Geoffrey Brooks, Thu Ha Dang, Elizabeth Ellen Roughead
One third of the world's population lacks regular access to essential medicines partly because of the high cost of medicines. In Vietnam, the cost to patients of medicines was 47 times the international reference price for originator brands and 11 times the price for generic equivalents in the public sector. In this article, we report the results of a qualitative study conducted to identify the principal reasons for inflated medicine prices in Vietnam.Between April 2008 and December 2009, 29 semi-structured interviews were conducted with staff from pharmaceutical companies, private pharmacies, the Ministry of Health, and the Ministry of Finance of Vietnam...
June 1, 2017: Health Policy and Planning
https://www.readbyqxmd.com/read/28451441/performance-evaluation-of-the-compounding-robot-apotecachemo-for-injectable-anticancer-drugs-in-a-japanese-hospital
#14
Takuya Iwamoto, Takuya Morikawa, Miki Hioki, Hirofumi Sudo, Demis Paolucci, Masahiro Okuda
BACKGROUND: The accuracy, safety and feasibility of, the compounding robot APOTECAchemo were evaluated in the clinical practice of Japan. METHODS: Accuracy and precision of robotic preparations by APOTECAchemo was evaluated in 20 preparations of fluorouracil (FU) and cyclophosphamide (CPA) infusions by four pharmacists. Environmental and product contaminations with FU and CPA were evaluated by wipe testing. Robotic performance was compared with manual preparation in a biological safety cabinet...
2017: Journal of Pharmaceutical Health Care and Sciences
https://www.readbyqxmd.com/read/28443519/atranorin-an-interesting-lichen-secondary-metabolite
#15
Elżbieta Studzińska-Sroka, Agnieszka Galanty, Wiesława Bylka
Atranorin, the compound with the depside structure, is one of the most common lichen secondary metabolites, characteristic for numerous lichen families but rarely found in some mosses and higher plants. Over the years various biological properties of atranorin were examined. This review summarises the studies on atranorin, focusing on a number of biological activities in different fields. The literature describes anti-inflammatory, analgesic, as well as wound healing, antibacterial, antifungal, cytotoxic, antioxidant, antiviral, and immunomodulatory activities of the depside...
April 24, 2017: Mini Reviews in Medicinal Chemistry
https://www.readbyqxmd.com/read/28429389/evaluation-of-real-time-data-obtained-from-gravimetric-preparation-of-antineoplastic-agents-shows-medication-errors-with-possible-critical-therapeutic-impact-results-of-a-large-scale-multicentre-multinational-retrospective-study
#16
R Terkola, M Czejka, J Bérubé
WHAT IS KNOWN AND OBJECTIVE: Medication errors are a significant cause of morbidity and mortality especially with antineoplastic drugs, owing to their narrow therapeutic index. Gravimetric workflow software systems have the potential to reduce volumetric errors during intravenous antineoplastic drug preparation which may occur when verification is reliant on visual inspection. Our aim was to detect medication errors with possible critical therapeutic impact as determined by the rate of prevented medication errors in chemotherapy compounding after implementation of gravimetric measurement...
April 21, 2017: Journal of Clinical Pharmacy and Therapeutics
https://www.readbyqxmd.com/read/28415075/hopbase-a-unified-resource-for-humulus-genomics
#17
Steven T Hill, Ramcharan Sudarsanam, John Henning, David Hendrix
Hop (Humulus lupulus L. var lupulus) is a dioecious plant of worldwide significance, used primarily for bittering and flavoring in brewing beer. Studies on the medicinal properties of several unique compounds produced by hop have led to additional interest from pharmacy and healthcare industries as well as livestock production as a natural antibiotic. Genomic research in hop has resulted a published draft genome and transcriptome assemblies. As research into the genomics of hop has gained interest, there is a critical need for centralized online genomic resources...
January 1, 2017: Database: the Journal of Biological Databases and Curation
https://www.readbyqxmd.com/read/28404759/paving-the-way-for-dose-banding-of-chemotherapy-an-analytical-approach
#18
Heike Reinhardt, Rainer Trittler, Alison G Eggleton, Stefan Wöhrl, Thomas Epting, Marion Buck, Sabine Kaiser, Daniel Jonas, Justus Duyster, Manfred Jung, Martin J Hug, Monika Engelhardt
Background: In an interdepartmental cooperation, we investigated the feasibility and benefits of implementing dose banding of chemotherapy at our medical center. Based on this concept, chemotherapy doses are clustered into bands of similar dosage levels, thereby allowing the preproduction of frequently used standard doses of drugs, with sufficient physicochemical stability. Although established practice in the United Kingdom, there is little published evidence of its introduction elsewhere. Methods: We performed an analysis of local prescribing practice (22,310 chemotherapies) and identified gemcitabine, 5-fluorouracil, and carboplatin, among various others, as cytotoxic drugs suitable for dose banding...
April 2017: Journal of the National Comprehensive Cancer Network: JNCCN
https://www.readbyqxmd.com/read/28399716/the-lgbtqi-health-forum-an-innovative-interprofessional-initiative-to-support-curriculum-reform
#19
Hannan M Braun, David Ramirez, Greg J Zahner, Eva Mae Gillis-Buck, Heather Sheriff, Marcus Ferrone
Lesbian, gay, bisexual, transgender, queer, and intersex (LGBTQI) individuals continue to face barriers to accessing appropriate and comprehensive healthcare. Compounding this problem, healthcare trainees report few training opportunities and low levels of preparedness to care for LGBTQI patients. In 2009, an interprofessional group of students and a faculty advisor at the University of California, San Francisco, developed a novel student-organized LGBTQI Health Forum for medical, dental, pharmacy, nursing, and physical therapy students to deliver LGBTQI health content that was otherwise absent from the formal curriculum...
2017: Medical Education Online
https://www.readbyqxmd.com/read/28361532/fused-deposition-modeling-enables-the-low-cost-fabrication-of-porous-customized-shape-sorbents-for-small-molecule-extraction
#20
Mariusz Belka, Szymon Ulenberg, Tomasz Bączek
Fused deposition modeling, one of the most common techniques in three-dimensional printing and additive manufacturing, has many practical applications in the fields of chemistry and pharmacy. We demonstrate that a thermoplastic elastomer-poly(vinyl alcohol) (PVA) composite material (LAY-FOMM 60), which presents porous properties after PVA removal, is useful for the extraction of small-molecule drug-like compounds from water samples. The usefulness of the proposed approach is demonstrated by the extraction of glimepiride from a water sample, followed by LC-MS analysis...
April 7, 2017: Analytical Chemistry
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