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Compounding pharmacy

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https://www.readbyqxmd.com/read/29650727/a-pharmacy-led-united-states-pharmacopeia-usp-chapter-800-compliance-collaborative-at-an-academic-medical-center
#1
Bijan C Mekoba, Erin M Turingan, Patricia A Roberts, Susan Mason, Ian Willoughby, Cindy Taylor, Andrew Stivers, John Valgus
PURPOSE: One academic medical center's efforts to move toward compliance with requirements of United States Pharmacopeia ( USP ) chapter 800 through a multidepartmental collaborative initiative are described. SUMMARY: Requirements of USP general chapter 800 (enforceable as of December 2019) address the handling of hazardous drugs (HDs) throughout the entire operational and clinical cycle, from receiving to compounding, administration, and waste disposal. Due to the variety of pharmacy operational areas in which HDs are encountered at University of North Carolina Medical Center (UNCMC), multiple pharmacy managers oversee the safe handling of HDs...
April 12, 2018: American Journal of Health-system Pharmacy: AJHP
https://www.readbyqxmd.com/read/29608193/compounded-oral-viscous-budesonide-is-effective-and-provides-a-durable-response-in-eosinophilic-esophagitis
#2
Craig C Reed, Claire Fan, Nathaniel Koutlas, Zoe Stefanadis, Swathi Eluri, Nicholas J Shaheen, Evan S Dellon
Aim: Because no approved medications exist for eosinophilic esophagitis (EoE), patients must use off-label drugs or create their own formulations. We assessed the efficacy of a standardized compounded budesonide suspension for treatment of EoE. Materials and methods: We conducted a retrospective cohort study of EoE patients at the University of North Carolina treated with compounded budesonide dispensed by a specialty compounding pharmacy. Outcomes (symptomatic global response [yes/no], endoscopic response [% with individual findings], and histologic response [absolute eosinophil count; % with <15 eos/hpf])were assessed after the initial and last treatment in our system...
2018: HSOA journal of gastroenterology & hepatology research
https://www.readbyqxmd.com/read/29605949/quality-pharmacy-services-and-key-performance-indicators-in-polish-nicus-a-delphi-approach
#3
Natalia Krzyżaniak, Iga Pawłowska, Beata Bajorek
Background Currently, there is no literature describing what a quality level of practice entails in Polish neonatal intensive care units (NICUs), nor are there any means of currently measuring the quality of pharmaceutical care provided to NICU patients. Objective To identify a set of essential pharmacist roles and pharmacy-relevant key performance indicators (KPI's) suitable for Polish neonatal intensive units (NICUs). Setting Polish hospital pharmacies and NICUs. Method Using a modified Delphi technique, potential KPI's structured along Donabedian's domains as well as pharmacy services were presented to an expert panel of stakeholders...
March 31, 2018: International Journal of Clinical Pharmacy
https://www.readbyqxmd.com/read/29572316/creating-a-learning-organization-to-help-meet-the-needs-of-multihospital-health-systems
#4
Angela Ward, Nannette Berensen, Rowell Daniels
PURPOSE: The considerations that leaders of multihospital health systems must take into account in developing and implementing initiatives to build and maintain an exceptional pharmacy workforce are described. SUMMARY: Significant changes that require constant individual and organizational learning are occurring throughout healthcare and within the profession of pharmacy. These considerations include understanding why it is important to have a succession plan and determining what types of education and training are important to support that plan...
April 1, 2018: American Journal of Health-system Pharmacy: AJHP
https://www.readbyqxmd.com/read/29554767/steroid-hormonal-bioactivities-culprit-natural-and-synthetic-hormones-and-other-emerging-contaminants-in-waste-water-measured-using-bioassays-and-uplc-tq-ms
#5
Corine J Houtman, Rob Ten Broek, Abraham Brouwer
Emission of compounds with biological activities from waste water treatment plant (WWTP) effluents into surface waters is a topic of concern for ecology and drinking water quality. We investigated the occurrence of hormone-like activities in waste water sample extracts from four Dutch WWTPs and pursued to identify compounds responsible for them. To this aim, in vitro reporter gene bioassays for androgenic, anti-androgenic, estrogenic, glucocorticoid and progestogenic activity and a UPLC-tQ-MS target analysis method for 25 steroid hormones used in high volumes in pharmacy were applied...
March 5, 2018: Science of the Total Environment
https://www.readbyqxmd.com/read/29540104/stability-of-vincristine-sulfate-doxorubicin-hydrochloride-and-etoposide-phosphate-admixtures-in-polyisoprene-elastomeric-pump-supporting-transition-of-the-epoch-regimen-to-outpatient-care
#6
Darren Svirskis, Sairam Behera, Neera Naidoo, Joanne Beachman, Tarsha Raina, Yongzhi Zhou, Leanne Berkahn, Ian Costello, Yongchuan Gu
Background The EPOCH regimen, consisting of vincristine sulfate, doxorubicin hydrochloride, and etoposide phosphate, is typically administered by continuous infusion over four days to oncology inpatients. If the EPOCH regimen was available to be administered through portable elastomeric pumps, chemotherapy could be transitioned to an outpatient setting, reducing inpatient bed days and overall healthcare costs. However, a lack of stability data for the admixtures in the elastomeric infusion devices currently prevents the transition of the regime to an outpatient setting...
January 1, 2018: Journal of Oncology Pharmacy Practice
https://www.readbyqxmd.com/read/29516426/characterization-of-industrial-odor-sources-in-binhai-new-area-of-tianjin-china
#7
Bo Han, Ya-Ting Liu, Jian-Hui Wu, Yin-Chang Feng
Samples were collected from six different organized industrial odor sources in Tianjin Binhai New Area, including pharmacy, paint spraying, oil refinery, petrochemical, resin synthesis, and rubber manufacturing. Chemical analysis was conducted to identify and quantify major odorous volatile organic compounds (VOCs) and subsequently, establish source profiles. Olfactory measurement was used to characterize the sensory stimulating intensity of odorous VOCs and express them as odor concentration. The TVOC mass concentrations of these six sources were between 10...
March 7, 2018: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/29516141/4-hydroxybenzoic-acid-a-versatile-platform-intermediate-for-value-added-compounds
#8
REVIEW
Songwei Wang, Muhammad Bilal, Hongbo Hu, Wei Wang, Xuehong Zhang
4-Hydroxybenzoic acid (4-HBA) has recently emerged as a promising intermediate for several value-added bioproducts with potential biotechnological applications in food, cosmetics, pharmacy, fungicides, etc. Over the past years, a variety of biosynthetic techniques have been developed for producing the 4-HBA and 4-HBA-based products. At this juncture, synthetic biology and metabolic engineering approaches enabled the biosynthesis of 4-HBA to address the increasing demand for high-value bioproducts. This review summarizes the biosynthesis of a variety of industrially pertinent compounds such as resveratrol, muconic acid, gastrodin, xiamenmycin, and vanillyl alcohol using 4-HBA as the starting feedstock...
March 7, 2018: Applied Microbiology and Biotechnology
https://www.readbyqxmd.com/read/29510165/pre-and-post-intervention-study-of-antiblastic-drugs-contamination-surface-levels-at-a-pharmacy-department-compounding-area-using-a-closed-system-drug-transfer-device-and-a-decontamination-process
#9
Silvia Valero, Eduardo López-Briz, Nieves Vila, Antonio Solana, Mar Melero, Jose Luis Poveda
Assuring healthcare workers security on Hazardous Drugs (HD) compounding is critical in healthcare settings. Our study aims to demonstrate that the use of a Close System drug Transfer Device (CSTD) PhaSeal™ added to a decontamination process reduces antiblastic surface contamination levels in the Compounding Area (CA) of our Pharmacy Department (PD). We selected cyclophosphamide, 5-fluorouracil and iphosphamide to be evaluated. Testing was carried out with a wipe kit and quantified by an independent laboratory...
March 3, 2018: Regulatory Toxicology and Pharmacology: RTP
https://www.readbyqxmd.com/read/29501781/economic-and-practical-considerations-in-the-treatment-of-oral-mucosal-chronic-graft-versus-host-disease
#10
Sharon Elad, Kevin Zinchuk, Shuli Li, Corey Cutler, Jane Liesveld, Nathaniel Treister
Chronic graft-versus-host disease (cGVHD) frequently affects the oral mucosa and is generally responsive to topical immunomodulatory therapies. Clinicians may benefit from guidance in choosing the most appropriate therapy with respect to practicality and cost. To assess the economic considerations related to topical immunomodulatory treatments for management of oral mucosal cGVHD and their practical implications. Topical treatments used for management of oral cGVHD were obtained from the National Institutes of Health Consensus document for ancillary and supportive care...
March 2, 2018: Biology of Blood and Marrow Transplantation
https://www.readbyqxmd.com/read/29501060/consensus-seo-sefh-of-recommendations-for-use-and-compounding-of-ophthalmic-preparations
#11
Raquel Fuentes-Irigoyen, Ana María Martín de Rosales Cabrera, Ana Cristina Riestra, María Nieves Vila, Carmela Dávila-Pousa, José María Alonso Herreros, Carmen López-Cabezas, Carmen Cañete, María Sagrario Pernía-López, Marta Garcia-Palomo, Pedro Arriola Villalobos, Lucía Ibares-Frías, José Luís Urcelay Segura, Jacobo Ramón Yañez Martínez
There are many medicinal products that, although having shown efficacy and  safety in different ophthalmological indications, they are not authorized or  commercially available for ophthalmic administration. This implies, on one hand,  that they must be used according to legislation that regulates the availability of  medicines in special situations and, on the other hand, that they must be  prepared in the pharmacy services for ophthalmic administration, according to  quality criteria to ensure its effectiveness, stability and sterility...
March 1, 2018: Farmacia Hospitalaria
https://www.readbyqxmd.com/read/29472506/recent-fda-compounding-guidances-to-pharmacies-may-not-apply-everywhere
#12
Cheryl A Thompson
No abstract text is available yet for this article.
March 1, 2018: American Journal of Health-system Pharmacy: AJHP
https://www.readbyqxmd.com/read/29469168/screening-of-key-odorants-and-anthocyanin-compounds-of-cv-okuzgozu-vitis-vinifera-l-red-wines-with-a-free-run-and-pressed-pomace-using-gc-ms-olfactometry-and-lc-ms-ms
#13
Mehmet Ali Tetik, Onur Sevindik, Hasim Kelebek, Serkan Selli
The principal purpose of the present work is to characterize the aroma, aroma-active, and anthocyanin profiles of Okuzgozu wines and to observe the effect of the pomace pressing technique on these parameters. A total of 58 and 59 volatile compounds were identified and quantified in free-run juice wine (FRW) and pressed pomace wine (PW). Alcohols were found as the most dominant group among aroma compounds followed by esters and acids. However, among all these compounds only 11 and 13 of them could be considered as key odorants in aromatic extracts of FRW and PW, respectively...
February 22, 2018: Journal of Mass Spectrometry: JMS
https://www.readbyqxmd.com/read/29441959/stability-studies-of-five-anti-infectious-eye-drops-under-exhaustive-storage-conditions
#14
C Curti, E Lamy, N Primas, C Fersing, C Jean, P Bertault-Peres, P Vanelle
Several ocular infections require anti-infectious eye drops prepared by hospital pharmacy. Stability of these preparations is described in the literature, but studies do not always adequately consider physico-chemical parameters or storage conditions. We describe herein a complete study conducted on five anti-infectious eye drops containing vancomycin, gentamicin, ceftazidime, amphotericin B and voriconazole. We looked for significant changes in active pharmaceutical ingredient content, pH, osmolality and subvisible particles...
December 1, 2017: Die Pharmazie
https://www.readbyqxmd.com/read/29435139/quantitative-high-throughput-phenotypic-screening-of-pediatric-cancer-cell-lines-identifies-multiple-opportunities-for-drug-repurposing
#15
Min Shen, Rosita Asawa, Ya-Qin Zhang, Elizabeth Cunningham, Hongmao Sun, Alexander Tropsha, William P Janzen, Eugene N Muratov, Stephen J Capuzzi, Sherif Farag, Ajit Jadhav, Julie Blatt, Anton Simeonov, Natalia J Martinez
Drug repurposing approaches have the potential advantage of facilitating rapid and cost-effective development of new therapies. Particularly, the repurposing of drugs with known safety profiles in children could bypass or streamline toxicity studies. We employed a phenotypic screening paradigm on a panel of well-characterized cell lines derived from pediatric solid tumors against a collection of ∼3,800 compounds spanning approved drugs and investigational agents. Specifically, we employed titration-based screening where compounds were tested at multiple concentrations for their effect on cell viability...
January 12, 2018: Oncotarget
https://www.readbyqxmd.com/read/29415431/the-magistral-phage
#16
Jean-Paul Pirnay, Gilbert Verbeken, Pieter-Jan Ceyssens, Isabelle Huys, Daniel De Vos, Charlotte Ameloot, Alan Fauconnier
Since time immemorial, phages-the viral parasites of bacteria-have been protecting Earth's biosphere against bacterial overgrowth. Today, phages could help address the antibiotic resistance crisis that affects all of society. The greatest hurdle to the introduction of phage therapy in Western medicine is the lack of an appropriate legal and regulatory framework. Belgium is now implementing a pragmatic phage therapy framework that centers on the magistral preparation (compounding pharmacy in the US) of tailor-made phage medicines...
February 6, 2018: Viruses
https://www.readbyqxmd.com/read/29414124/a-novel-unit-dose-approach-for-the-pharmaceutical-compounding-of-an-orodispersible-film
#17
Wen Chin Foo, Yuet Mei Khong, Rajeev Gokhale, Sui Yung Chan
Orodispersible films (ODF) have clinical potential as extemporaneous pharmacy preparations for individualized pharmacotherapy. However, the conventional method of ODF preparation using a film applicator may limit its application, due to content uniformity challenges arising from viscosity changes of the casting solution and varied operator manipulation. This study proposes the unit-dose (UD) plate as an alternative to the film applicator for compounding individual ODFs. Using a design-of-experiments approach, we developed an extemporaneous ODF formulation for an antiemetic drug, ondansetron hydrochloride dihydrate (OND), at a clinically relevant dose...
January 31, 2018: International Journal of Pharmaceutics
https://www.readbyqxmd.com/read/29385385/sterile-basics-of-compounding-relationship-between-syringe-size-and-dosing-accuracy
#18
Tracy M Kosinski, Michael C Brown, Pedro J Zavala
The purpose of this study was to investigate the accuracy and reproducibility of a 2-mL volume injection using a 3-mL and 10-mL syringe with pharmacy student compounders. An exercise was designed to assess each student's accuracy in compounding a sterile preparation with the correct 4-mg strength using a 3-mL and 10-mL syringe. The average ondansetron dose when compounded with the 3-mL syringe was 4.03 mg (standard deviation ± 0.45 mg), which was not statistically significantly different than the intended 4-mg desired dose (P=0...
January 2018: International Journal of Pharmaceutical Compounding
https://www.readbyqxmd.com/read/29385384/basics-of-compounding-providing-pharmacy-services-to-bariatric-surgery-patients
#19
Linda F McElhiney
With the rise in obesity, more individuals are choosing bariatric surgery as a means to successfully lose weight and resolve co-morbidities. These patients need lifelong support from friends, family, and healthcare providers. Pharmacists need to be knowledgeable of the unique needs of these patients in order to provide information and recommendations on drug therapies and supplements. When a patient is wheeled out of the operating room following bariatric surgery, his or her life instantly changes. Like an infant, the patient has to slowly learn how to eat and drink again...
January 2018: International Journal of Pharmaceutical Compounding
https://www.readbyqxmd.com/read/29385382/pain-systematic-review-of-pharmacy-compounding-of-pain-medication
#20
Mohammad S Shawaqfeh, Catherine Harrington
There are limited resources available for pharmacists and doctors to reference proper compounded formulas for pain medications. The systematic review discussed within this article provides the foundation for a searchable database, allowing users to find various compounded formulations. It also provides data about the safety and efficacy of the preparations. Compounding information about several drug classes was reviewed. Those drug classes included, but were not limited to, opioids, non-steroidal anti-inflammatory drugs, central nervous system agents, and anesthetics, with evidence that of the various drugs that could be compounded for pain, anesthetics, non-steroidal anti-inflammatory drugs, and opioids ranked highest within the articles researched...
January 2018: International Journal of Pharmaceutical Compounding
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