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Compounding pharmacy

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https://www.readbyqxmd.com/read/29037451/-city-hospital-network-and-quality-control-of-officinal-preparations
#1
C Curti, S Gallice, E Lamy, P Rathelot, P Vanelle
OBJECTIVES: In a hospital environment, the quality control of the hospital preparations allows to release homogeneous batches in a secure way. These controls are totally integrated into the process of production and can also, in certain cases, be realized for high-alert magistral preparations. In community pharmacy, these controls were not required, but the Agence régionale de santé (ARS) recently incited compounding community pharmacies to realize this type of analyses. This decision motivated the creation of a collaboration between the pharmacy department of a French teaching hospital and a society including around thirty community pharmacies having a preparatory...
October 13, 2017: Annales Pharmaceutiques Françaises
https://www.readbyqxmd.com/read/29029106/iatrogenic-cushing-syndrome-in-a-child-with-congenital-adrenal-hyperplasia-erroneous-compounding-of-hydrocortisone
#2
Julia E Barillas, Daniel Eichner, Ryan Van Wagoner, Phyllis W Speiser
Context: Patients with 21-hydroxylase deficiency congenital adrenal hyperplasia (CAH) require lifelong treatment with glucocorticoids. In growing children the drug of choice is hydrocortisone. Commercially available hydrocortisone tablets do not conform to very low doses prescribed to infants and toddlers, and compounded hydrocortisone is often dispensed to meet therapeutic needs. However, safety, efficacy and uniformity of compounded products are not tested. We report a case of Cushing syndrome in a child with CAH who was inadvertently receiving excessive hydrocortisone in compounded form...
September 28, 2017: Journal of Clinical Endocrinology and Metabolism
https://www.readbyqxmd.com/read/29028251/monitoring-surface-contamination-by-antineoplastic-drugs-in-italian-hospitals-performance-based-hygienic-guidance-values-hgvs-project
#3
Cristina Sottani, Elena Grignani, Enrico Oddone, Beatrice Dezza, Sara Negri, Simona Villani, Danilo Cottica
Antineoplastic drugs (ADs) will continue to represent a potential risk for personnel involved in the handling of these compounds and great concerns have been raised by the presence of ADs in many surveyed workplaces. Eight hospitals were investigated by means of wipe sampling for surface residue determination. Each wipe sample was tested for five ADs considered suitable exposure markers. Cyclophosphamide (CP), gemcitabine (GEM), 5-fluorouracil (5-FU), platinum-containing drugs (Pt), and epi-doxorubicin (EPI) contamination levels were measured in 85 per cent of the studied pharmacies and 93 per cent of outpatient care units (OpCUs)...
October 1, 2017: Annals of Work Exposures and Health
https://www.readbyqxmd.com/read/28970616/acquisition-and-retention-of-sterile-compounding-accuracy-skills
#4
Tracy M Kosinski, Michael C Brown, Katie Valdovinos, Pedro J Zavala
Objective. To determine the accuracy of dose of pharmacy students' parenteral sterile preparation skills and to measure pharmacy students' skill retention 1.5 years later. Methods. An exercise was designed to assess each student's accuracy in compounding a sterile preparation with the correct potency during a second and then third year course. Results. Initially, the mean (standard deviation) of 141 students' compounded preparation dose was not significantly different than the desired dose. Additionally, 91...
August 2017: American Journal of Pharmaceutical Education
https://www.readbyqxmd.com/read/28970458/current-status-and-future-suggestions-for-improving-the-pharm-d-curriculum-towards-clinical-pharmacy-practice-in-pakistan
#5
Saima Mahmood Malhi, Hassan Raza, Kiran Ajmal, Sumbul Shamim, Saniya Ata, Salman Farooq, Syed Muhammad Sharib, Sidrat-Ul Muntaha
Objectives & Background: Good curriculum is reflected as the backbone for standard universities to develop competitive professionals having great potential. Pharmacy education in Pakistan has gone through the same developmental stages as in other countries, but is still striving for improvement. In the present study, we want (i) to know the opinion on whether the current pharmacy curriculum requires any improvement in order to meet the training needs of pharmacy professionals regarding clinical knowledge and pharmacy practice; and (ii) to present some humble suggestions to decision-making authorities in order to improve it with respect to patient-focused programs (PFP)...
August 17, 2017: Pharmacy (Basel, Switzerland)
https://www.readbyqxmd.com/read/28967825/evaluation-of-drug-content-potency-for-compounded-and-fda-approved-formulations-of-doxycycline-on-receipt-and-after-21-days-of-storage
#6
Kate KuKanich, Butch KuKanich, Tanner Slead, Matt Warner
OBJECTIVE To determine drug content (potency) of compounded doxycycline formulations for veterinary use and of US FDA-approved doxycycline formulations for human use < 24 hours after receipt (day 1) and after 21 days of storage under recommended conditions (day 21). DESIGN Evaluation study. SAMPLE FDA-approved doxycycline tablets (100 mg), capsules (100 mg), and liquid suspension (10 mg/mL) and compounded doxycycline formulations from 3 pharmacies (tablets [25, 100, and 150 mg; 1 product/source], chews [100 mg; 1 product/source], and liquid suspensions or solution [6 mg/mL {2 sources} and 50 mg/mL {1 source}])...
October 1, 2017: Journal of the American Veterinary Medical Association
https://www.readbyqxmd.com/read/28960556/incidence-of-pyrrolizidine-alkaloids-in-herbal-medicines-from-german-retail-markets-risk-assessments-and-implications-to-consumers
#7
Emmanuel Letsyo, Gerold Jerz, Peter Winterhalter, Rainer Lindigkeit, Till Beuerle
The occurrence of potentially toxic pyrrolizidine alkaloids (PAs) in herbal medicines (HMs) is currently intensely being discussed in Europe. Pyrrolizidine alkaloids, particularly the 1,2-unsaturated PAs, are undesired compounds in HMs due to their potential hepatotoxic and carcinogenic properties. In this study, 98 widely patronized HMs from six popular German retail supermarkets/drugstores, as well as from pharmacies, were analyzed by high-performance liquid chromatography-electrospray ionization-tandem mass spectrometry for the presence of PAs...
September 28, 2017: Phytotherapy Research: PTR
https://www.readbyqxmd.com/read/28956261/kefir-a-powerful-probiotics-with-anticancer-properties
#8
REVIEW
Mohammadreza Sharifi, Abbas Moridnia, Deniz Mortazavi, Mahsa Salehi, Marzieh Bagheri, Abdolkarim Sheikhi
Probiotics and fermented milk products have attracted the attention of scientists from various fields, such as health care, industry and pharmacy. In recent years, reports have shown that dietary probiotics such as kefir have a great potential for cancer prevention and treatment. Kefir is fermented milk with Caucasian and Tibet origin, made from the incubation of kefir grains with raw milk or water. Kefir grains are a mixture of yeast and bacteria, living in a symbiotic association. Antibacterial, antifungal, anti-allergic and anti-inflammatory effects are some of the health beneficial properties of kefir grains...
September 27, 2017: Medical Oncology
https://www.readbyqxmd.com/read/28952614/quercetin-and-its-analogues-optical-and-acido-basic-properties
#9
Michal Biler, David Biedermann, Kateřina Valentová, Vladimír Křen, Martin Kubala
This study is focused on eight structurally analogous natural flavonoids that exhibit a wide range of biological activities, which are of interest in pharmacy, cosmetics and the food industry. Using both experimental and theoretical approaches, we relate their fundamental physico-chemical properties to the structural motifs, with particular focus on UV/Vis absorption properties and pH dependence. We highlight the role of the C2-C3 double bond, whose presence or absence is responsible for the switch between absorption bands in the UVB and UVA regions, which is rationalized by strong modification of the involved molecular orbitals...
October 11, 2017: Physical Chemistry Chemical Physics: PCCP
https://www.readbyqxmd.com/read/28933730/veterinary-pharmaceutics-an-opportunity-for-interprofessional-education-in-new-zealand
#10
Arlene McDowell, Rebekah Beard, Anna Brightmore, Lisa W Lu, Amelia McKay, Maadhuri Mistry, Kate Owen, Emma Swan, Jessica Young
Globally pharmacists are becoming increasingly involved in veterinary medicine; however, little is known about the level of interest for pharmacists playing a larger role in animal treatment in New Zealand. A key stakeholder in any progression of pharmacists becoming more involved in the practice of veterinary pharmacy is the veterinary profession. The aim of this study was to investigate views of veterinarians and veterinary students on the role of pharmacists supporting veterinarians with advice on animal medicines...
July 26, 2017: Pharmaceutics
https://www.readbyqxmd.com/read/28933275/a-case-of-inappropriate-self-medication-compounded-with-prescribing-vis-%C3%A3-vis-dispensing-errors-and-the-hazardous-consequence
#11
Sukalyan Saha Roy, Anupam Roy, Ranjita Santra Dhali, Chiranjib Bagchi, Gautam Banerjee, Santanu K Tripathi
INTRODUCTION Dispensing error, a type of medication error, is not infrequent but seldom reported. Self-medication behavior appears to be a commonplace. And when it is ignorant it may prove dangerous. We report here a case of acute vesico-bullous eruptions from methotrexate in a patient of psoriasis who indulged in self-medication and was wrongfully dispensed higher doses of methotrexate. CASE DESCRIPTION A 50-year-old gentleman presented to the dermatology OPD with erythematous, vesico-bullar lesions spread all over the body including both limbs and scalp, with oral mucosal involvement without any history of fever...
September 19, 2017: Current Drug Safety
https://www.readbyqxmd.com/read/28929406/pharmacopollution-and-household-waste-medicine-hwm-how-reverse-logistics-is-environmentally-important-to-brazil
#12
André Luiz Pereira, Raphael Tobias de Vasconcelos Barros, Sandra Rosa Pereira
Pharmacopollution is a public health and environmental outcome of some active pharmaceutical ingredients (API) and endocrine-disrupting compounds (EDC) dispersed through water and/or soil. Its most important sources are the pharmaceutical industry, healthcare facilities (e.g., hospitals), livestock, aquaculture, and households (patients' excretion and littering). The last source is the focus of this article. Research questions are "What is the Household Waste Medicine (HWM) phenomenon?", "How HWM and pharmacopollution are related?", and "Why is a reverse logistic system necessary for HWM in Brazil?" This article followed the seven steps proposed by Rother (2007) for a systematic review based on the Cochrane Handbook and the National Health Service (NHS) Center for Reviews Dissemination (CDR) Report...
September 19, 2017: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/28913839/long-term-stability-of-a-compounded-suspension-of-torsemide-5-mg-ml-for-oral-administration
#13
D Adin, P R Johnson, C H Kim, T Nguyenba, S Rosen
BACKGROUND: Torsemide use for congestive heart failure (CHF) has been reported, but prescription frequency is unknown. Commercially available tablet sizes in North America limit dosing precision, indicating a need to evaluate its strength and stability in suspension. OBJECTIVES: To determine the frequency of torsemide prescriptions and to determine a beyond use date (BUD) of a compounded suspension of torsemide for oral administration stored under 2 temperature conditions for 90 days...
September 15, 2017: Journal of Veterinary Internal Medicine
https://www.readbyqxmd.com/read/28880141/-clioquinol-use-for-dientamoeba-fragilis-infections-is-questionable
#14
F van Hunsel, C van Nieuwkoop, B H Ch Stricker
Clioquinol is used for treatment of amoebiasis and infection with Dientamoeba fragilis. In a guideline of the Dutch Working Party on Antibiotic Policy, clioquinol is recommended as a first-choice treatment for Dientamoeba fragilis. This drug, however, is associated with subacute myelo-optico-neuropathy (SMON). It was withdrawn from the market worldwide in 1985 by manufacturer Ciba-Geigy. Although the Dutch Medicines Evaluation Board has registered no products for systemic use of clioquinol since then, the drug is available as a pharmacy-compounded drug and the last few years the use of clioquinol in the Netherlands has risen again...
2017: Nederlands Tijdschrift Voor Geneeskunde
https://www.readbyqxmd.com/read/28867779/identification-and-analysis-of-amygdalin-neoamygdalin-and-amygdalin-amide-in-different-processed-bitter-almonds-by-hplc-esi-ms-ms-and-hplc-dad
#15
Shuya Xu, Xinfang Xu, Shaoxiong Yuan, Huan Liu, Mengnan Liu, Ying Zhang, Hui Zhang, Yan Gao, Ruichao Lin, Xiangri Li
Processing is a traditional pharmacy technology based on traditional Chinese medicine theory. The traditional Chinese medicine (TCM) ingredients should be processed before being used as a medicine. Processed bitter almonds are widely used in the clinic in TCM for the treatment of cough and asthma. In this work the amygdalin profile of three producing areas in China was determined, with respect to three differently processed bitter almond products: raw, stir-fried and scalded. Identification of the compounds was done by using high performance liquid chromatography coupled to electrospray ionization mass spectrometry (HPLC-ESI-MS/MS)...
August 30, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/28865936/effectiveness-of-a-shielded-ultraviolet-c-air-disinfection-system-in-an-inpatient-pharmacy-of-a-tertiary-care-children-s-hospital
#16
Don Guimera, Jean Trzil, Joy Joyner, Nicholas D Hysmith
Viable air particles pose a risk in areas where sterile preparations are compounded. This study investigated the efficacy of an innovative air purification technology that uses a shielded ultraviolet C light lamp to continuously purify the air in an inpatient pharmacy. Mean airborne fungal and bacterial colony forming units were obtained preinstallation and again in 6 months. A statistically significant decrease of 78% and 62% was observed for fungal and bacterial particles, respectively. This study demonstrates a potential role for this novel technology in decreasing the spread of airborne pathogens...
August 30, 2017: American Journal of Infection Control
https://www.readbyqxmd.com/read/28841584/contamination-of-anti-vegf-drugs-for-intravitreal-injection-how-do-repackaging-and-newly-developed-syringes-affect-the-amount-of-silicone-oil-droplets-and-protein-aggregates
#17
Marc Schargus, Benjamin P Werner, Gerd Geerling, Gerhard Winter
PURPOSE: The particle counts and the nature of particles of three different antivascular endothelial growth factor agents (VEGF) in different containers in a laboratory setting were compared. METHODS: Original prefilled ranibizumab glass syringes, original vials with aflibercept, and repacked ready-to-use plastic syringes with bevacizumab from a compounding pharmacy and a compounding company (CC) were analyzed. Particle counts and size distributions were quantified by different particle characterization methods (nephelometry, light obscuration, Micro-Flow Imaging, nanotracking analysis, resonant mass measurement)...
August 21, 2017: Retina
https://www.readbyqxmd.com/read/28801944/the-emergence-of-second-generation-lethal-injection-protocols-a-brief-history-and-review
#18
Daniel R Malcom, Frank Romanelli
The history of capital punishment in the United States is long and controversial. In many cases, lethal injection has brought medical personnel, ethically and professionally charged with preserving life, into the arena of assisting the state in taking life. U.S. Supreme Court decisions, including Baze v. Rees (2008) and Glossip v. Gross (2015), have evaluated and condoned lethal injection protocols. Despite the judicial validation of some midazolam-containing protocols, controversy exists about the level of unconsciousness provided due to the ceiling effects of the drug...
August 12, 2017: Pharmacotherapy
https://www.readbyqxmd.com/read/28782167/plants-of-the-melaleuca-genus-as-antimicrobial-agents-from-farm-to-pharmacy
#19
REVIEW
Javad Sharifi-Rad, Bahare Salehi, Elena Maria Varoni, Farukh Sharopov, Zubaida Yousaf, Seyed Abdulmajid Ayatollahi, Farzad Kobarfard, Mehdi Sharifi-Rad, Mohammad Hossain Afdjei, Majid Sharifi-Rad, Marcello Iriti
Plants belonging to Melaleuca genus (Myrtaceae family) are native to Oceania, where they have been used for ages by Aborigine people in Australian traditional medicine, mainly because of their broad-spectrum antimicrobial activity. Although, M. linariifolia, M. dissitiflora, and other species of Melaleuca can also be used, the tea tree oil, an essential oil obtained from M. alternifolia shows the longest history of medicinal uses. Tea tree oil contains for the 80-90% several monoterpenes (terpinen-4-ol, α-terpinene, 1,8-cineol, p-cymene, α-terpineol, α-pinene, terpinolene, limonene, and sabinene)...
August 7, 2017: Phytotherapy Research: PTR
https://www.readbyqxmd.com/read/28743541/a-comparative-characterization-of-estrogens-used-in-hormone-therapy-via-estrogen-receptor-er-%C3%AE-and-%C3%AE
#20
Meghan S Perkins, Renate Louw-du Toit, Donita Africander
Conventional hormone therapy (HT) containing estrogens such as ethinylestradiol (EE) have been associated with an increased risk of breast cancer and cardiovascular disease resulting in women seeking safer alternatives that are claimed to have fewer health risks. One such alternative gaining popularity, is custom-compounded bioidentical (b)HT formulations containing bioidentical estradiol (bE2) and estriol (bE3). However, the preparation of these custom-compounded estrogens is not regulated, and depending on the route of synthesis, steroid mixtures with differing activities may be produced...
July 22, 2017: Journal of Steroid Biochemistry and Molecular Biology
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