Vinod Sukanth Kumar Pallabothula, Nechirwan Taimur Abdalrahman, Matteo Mori, Amir Hossein Fekri, Ondřej Janďourek, Klára Konečná, Pavla Paterová, Martin Novák, Paulína Dudášová-Hatoková, Petra Štěrbová-Kovaříková, Carlo Castellano, Fiorella Meneghetti, Stefania Villa, Jiří Kuneš, Martin Juhás, Jan Zitko
This study presents an exploration of the chemical space around derivatives of 3-benzamidopyrazine-2-carboxamides, previously identified as potent antimycobacterial compounds with predicted binding to mycobacterial prolyl-transfer RNA synthetase. New urea derivatives (Series-1) were generally inactive, probably due to their preference for cis-trans conformation (confirmed by density functional theory calculations and experimentally by nuclear overhauser effect spectroscopy NMR). Series-2 (3-benzamidopyrazine-2-carboxamides with disubstituted benzene ring) demonstrated that substituents larger than fluorine are not tolerated in the ortho position of the benzene ring...
May 6, 2024: Archiv der Pharmazie