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Compounding pharmacy

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https://www.readbyqxmd.com/read/28724837/chemical-analysis-of-counterfeit-hepatitis-c-drug-found-in-japan
#1
Nahoko Uchiyama, Hiroyuki Kamakura, Sayaka Masada, Takashi Tsujimoto, Junko Hosoe, Hiroko Tokumoto, Takuro Maruyama, Yukihiro Goda, Takashi Hakamatsuka
<bibitem lang="en">  In January 2017, counterfeits of the hepatitis C drug 'HARVONI(®) Combination Tablets' (HARVONI(®)) were found at a pharmacy chain through unlicensed suppliers in Japan. A total of five lots of counterfeit HARVONI(®) (samples 1-5) bottles were found, and the ingredients of the bottles were all in tablet form. Among them, two differently shaped tablets were present in two of the bottles (categorized as samples 2A, 2B, 4A, and 4B). We analyzed the total of seven samples by high-resolution LC-MS, GC-MS and NMR...
July 19, 2017: Yakugaku Zasshi: Journal of the Pharmaceutical Society of Japan
https://www.readbyqxmd.com/read/28721095/chemotherapy-associated-paronychia-treated-with-2-povidone-iodine-a-series-of-cases
#2
Kara Capriotti, Joseph Capriotti, Jesse Pelletier, Kevin Stewart
BACKGROUND: Nail changes are known to occur during the use of chemotherapy for a variety of malignancies, particularly those treated with taxanes and EGFR inhibitors. There are currently no actively recruiting prospective clinical trials investigating potential treatments. There are also no US Food and Drug Administration-approved medical treatments for chemotherapy-associated paronychia and no consensus on the best way to treat these common chemotherapy-induced events. METHODS: A retrospective review of all cases presenting to a single dermatology private practice from June 2016 to January 2017 identified nine patients with chemotherapy-associated paronychia seeking treatment...
2017: Cancer Management and Research
https://www.readbyqxmd.com/read/28720913/should-torsion-balance-technique-continue-to-be-taught-to-pharmacy-students
#3
Rhonda Bilger, Rasma Chereson, Noha Nabil Salama
Objective. To determine the types of balances used in compounding pharmacies: torsion or digital. Methods. A survey was mailed to the pharmacist-in-charge at 698 pharmacies, representing 47% of the pharmacies in Missouri as of July 2013. The pharmacies were randomly selected and stratified by region into eight regions to ensure a representative sample. Information was gathered regarding the type and use of balances and pharmacists' perspectives on the need to teach torsion balance technique to pharmacy students...
June 2017: American Journal of Pharmaceutical Education
https://www.readbyqxmd.com/read/28719372/basics-of-compounding-3d-printing-pharmacy-applications-part-3-compounding-formulation-considerations-and-the-future
#4
Loyd V Allen
3D printing is a standard tool in the automotive, aerospace, and consumer goods in industry and is gaining traction in pharmaceutical manufacturing, which has introduced a new element into dosage form development. This article, which represents part 3 of a 3-part article on the topic of 3D printing, discusses the compounding, formulation considerations, and the future of 3D printing.
July 2017: International Journal of Pharmaceutical Compounding
https://www.readbyqxmd.com/read/28719368/change-is-in-the-air-what-you-need-to-know-about-pharmacy-ventilation-under-united-states-pharmacopeia-800
#5
Cheryl Laniewicz
On July 1, 2018, United States Pharmacopeia <800> takes effect in those states that adopt it, and the discussion within this article may be applicable to those states that develop their own standards. United States Pharmacopeia <800> changes requirements for storage and compounding of hazardous drugs. The new requirements have important implications for air management and ventilation in some pharmacies. This article discusses how United States Pharmacopeia <800> compares to United States Pharmacopeia <797>, how the changes impact room ventilation and pressurization requirements, and how high-performance airflow control systems that ensure compliance and safety are impacted...
July 2017: International Journal of Pharmaceutical Compounding
https://www.readbyqxmd.com/read/28718679/salvia-fruticosa-modulates-mrna-expressions-and-activity-levels-of-xenobiotic-metabolizing-cyp1a2-cyp2e1-nqo1-gpx-and-gst-enzymes-in-human-colorectal-adenocarcinoma-ht-29-cells
#6
Ahmet Altay, Faruk Bozoğlu
Natural products have gained considerable interests because of their use in some industrial areas including nutrition, cosmetic, pharmacy, and medicine. Salvia fruticosa M. (Lamiaceae) is known for its antioxidant, antimicrobial, and antiproliferative activities. Phase I xenobiotic metabolizing enzymes, CYP1A2 and CYP2E1, produce reactive metabolites which are eliminated by the action of phase II enzymes, NQO1, GPx, and glutathione S-transferases (GSTs). In this study, in vitro modulatory effects of S. fruticosa and its major phenolic compound rosmarinic acid (RA) on CYP1A2, CYP2E1, NQO1, GPx, and GSTm1 mRNA expressions and enzyme activities of GPx and GSTs were investigated in HT-29 cells...
July 18, 2017: Nutrition and Cancer
https://www.readbyqxmd.com/read/28704319/topical-tacrolimus-for-corneal-subepithelial-infiltrates-secondary-to-adenoviral-keratoconjunctivitis
#7
Silvia Berisa Prado, Ana C Riestra Ayora, Carlos Lisa Fernández, Manuel Chacón Rodríguez, Jesús Merayo-Lloves, José F Alfonso Sánchez
PURPOSE: The objective of this study was to determine the efficacy and safety of topical tacrolimus compounded in the Pharmacy Service for the treatment of subepithelial corneal infiltrates (SEIs) secondary to adenoviral keratoconjunctivitis. METHODS: This retrospective study included patients who had been dispensed topical tacrolimus for the treatment of SEIs during the previous year. Patients were treated with tacrolimus 0.03% eye drops twice daily or tacrolimus 0...
July 11, 2017: Cornea
https://www.readbyqxmd.com/read/28703084/case-study-on-an-ipilimumab-cost-containment-strategy-in-an-italian-hospital
#8
Alberto Russi, Vanna Chiarion-Sileni, Vera Damuzzo, Francesca Di Sarra, Jacopo Pigozzo, Angelo Claudio Palozzo
OBJECTIVES: Ipilimumab is the first licensed immune checkpoint inhibitor for treatment of melanoma. The promising results of the registration clinical study need confirmation in real practice and its clinical success comes together with a relevant budget impact due to the high price of this drug. The aim of this work is to describe a new model of economical sustainability of ipilimumab developed in an Italian reference center for melanoma treatment. METHODS: This retrospective, observational, and monocentric study was carried out at the Veneto Institute of Oncology...
July 13, 2017: International Journal of Technology Assessment in Health Care
https://www.readbyqxmd.com/read/28687987/evaluation-of-the-crystallization-tendency-of-commercially-available-amorphous-tacrolimus-formulations-exposed-to-different-stress-conditions
#9
Niraj S Trasi, Hitesh S Purohit, Lynne S Taylor
PURPOSE: Tacrolimus, an immunosuppressant, is a poorly water soluble compound whereby the commercially available capsule formulations contain the drug in amorphous form. The goal of this study was to evaluate the robustness of the innovator product and five generic formulations to crystallization following storage at stress conditions. METHODS: Products were purchased from a pharmacy and stored at 40°C/75% relative humidity (RH), open dish conditions. Crystallinity was determined using X-ray diffraction...
July 7, 2017: Pharmaceutical Research
https://www.readbyqxmd.com/read/28628866/anticancer-drugs-consumption-trends-in-spain-prediction-of-environmental-concentrations-and-potential-risks
#10
Helena Franquet-Griell, Cristian Gómez-Canela, Francesc Ventura, Silvia Lacorte
This study presents the occurrence and impact of 78 anticancer drugs in Spanish river basins based on consumption data in pharmacies during the period 2010-2015 and calculation of the predicted environmental concentrations (PEC). The total consumption of anticancer drugs in Spanish pharmacies was of 23.4 tons in 2015, being mycophenolic acid and hydroxycarbamide the drugs with the highest prescription. Their PECs in river at national scale were up to 80 ng/L. However, the use of different dilution factors revealed major differences between hydrographic basins, and PECriver rose up to 68,014 ng/L in highly populated rivers with low flows...
June 16, 2017: Environmental Pollution
https://www.readbyqxmd.com/read/28617905/incidence-of-presumed-silicone-oil-droplets-in-the-vitreous-cavity-after-intravitreal-bevacizumab-injection-with-insulin-syringes
#11
Rahul N Khurana, Louis K Chang, Travis C Porco
Importance: Intravitreal bevacizumab is a frequently used antivascular endothelial growth factor medication in the United States, but its off-label use is associated with risks associated with the compounding preparation. Objective: To determine the incidence of presumed silicone oil droplets after intravitreal bevacizumab was prepared in insulin syringes by a compounding pharmacy. Design, Setting, and Participants: A retrospective review was conducted of 60 patients who experienced intravitreal silicone oil droplets in the eye after intravitreal bevacizumab injections from a single specialist practice from October 1, 2015, to November 30, 2016...
July 1, 2017: JAMA Ophthalmology
https://www.readbyqxmd.com/read/28591284/quality-of-bevacizumab-avastin%C3%A2-repacked-in-single-use-glass-vials-for-intravitreal-administration
#12
Michelle A A Sugimoto, Vicente de Paulo Coelho Peixoto de Toledo, Mariem Rodrigues Ribeiro Cunha, Virginia M Carregal, Rodrigo Jorge, Pedro Leão, Sílvia Ligorio Fialho, Armando Silva-Cunha
Purpose: Avastin® (bevacizumab) is an anti-vascular endothelial growth factor (VEGF) monoclonal antibody given as an off-label drug by intravitreal administration for treatment of ocular diseases. The drug's clinical application and its cost-benefit profile has generated demand for its division into single-use vials to meet the low volume and low-cost doses necessary for intraocular administration. However, the safety of compounding the drug in single-use vials is still under discussion...
March 2017: Arquivos Brasileiros de Oftalmologia
https://www.readbyqxmd.com/read/28576960/compounding-pharmacists-provide-customized-care
#13
Jennifer Burch
Compounding is the creation of a pharmaceutical preparation by a licensed pharmacist to meet the unique needs of an individual patient when commercially available drugs do not meet those needs. For hundreds of years, compounding was the traditional practice of pharmacy. Today's advanced practice of compounding provides health care practitioners customized options for unique patients or for hard to treat conditions.
May 2017: North Carolina Medical Journal
https://www.readbyqxmd.com/read/28557783/basics-of-compounding-3d-printing-pharmacy-applications-part-2
#14
Loyd V Allen
3D printing is a standard tool in the automotive, aerospace, and consumer goods in industry and is gaining traction in pharmaceutical manufacturing, which has introduced a new element into dosage-form development. This article, which represents part 2 of a 3-part article on the topic of 3D printing, discusses the different technologies available for 3D printing.
May 2017: International Journal of Pharmaceutical Compounding
https://www.readbyqxmd.com/read/28557780/microbiologic-testing-for-503a-sterile-compounding-pharmacies
#15
William Mixon, Abby Roth
Compounding pharmacists must ensure that the sterile preparations they dispense are free of microbiologic contamination. Working in a cleanroom under controlled conditions (proper differential air pressure, temperature, and humidity; acceptable levels of viable and nonviable airborne particles and surface counts, etc.) and testing the efficacy of cleaning and disinfecting practices via environmental monitoring (viable-air and surface testing, glove-fingertip-thumb testing, etc.) are essential to preparing contamination-free medications...
May 2017: International Journal of Pharmaceutical Compounding
https://www.readbyqxmd.com/read/28557779/adventures-in-the-environmental-world-and-environmental-microbiology-sampling-of-air-for-pharmaceutical-sterile-compounding
#16
Roberto Ligugnana
Chapter <797> issued by the United States Pharmacopeial Convention, Inc. is the standard for sterile compounding. It is designed to reduce the number of patient infections due to contaminated pharmaceutical preparation. This regulation applies to all staff who prepare compounded sterile preparations and all places where they are produced, including hospitals, clinics, pharmacies, and physician's offices. This article provides the history of environmental microbiology and provides a discussion on environmental microbiology sampling of air for pharmaceutical sterile compounding...
May 2017: International Journal of Pharmaceutical Compounding
https://www.readbyqxmd.com/read/28553184/initial-experience-in-the-use-of-technetium-99-metastable-hydroxymethylene-diphosphonate-as-an-alternative-ventilation-agent-during-periods-of-interim-shortage
#17
Colin Raymond Young, Kalpna Prasad
Sporadic supply interruptions of select radiopharmaceuticals on the global market require consideration of alternative agents to support continuity of essential nuclear medicine examinations. During an acute shortage of Xenon-133 and technetium-99 metastable (Tc-99m) diethylene-triamine-pentaacetate (DTPA), our institution used aerosolized Tc-99m hydroxymethylene diphosphonate (HDP), a radiopharmaceutical traditionally used in bone scintigraphy, in lieu of traditional ventilation agents, for two cases of suspected pulmonary embolism...
April 2017: World Journal of Nuclear Medicine
https://www.readbyqxmd.com/read/28539726/development-and-validation-of-a-simultaneous-rp-hplcuv-dad-method-for-determination-of-polyphenols-in-gels-containing-s-terebinthifolius-raddi-anacardiaceae
#18
Melina G Carvalho, Cícero F S Aragão, Fernanda N Raffin, Túlio F A de L Moura
Topical gels containing extracts of Schinus terebinthifolius have been used to treat bacterial vaginosis. It has been reported that this species has antimicrobial, anti-inflammatory and anti-ulcerogenic properties, which can be attributed to the presence of phenolic compounds. In this work, a sensitive and selective reversed-phase HPLC-UV/DAD method for the simultaneous assay of six polyphenols that could be present in S. terebinthifolius was developed. The method was shown to be accurate and precise. Peak purity and similarity index both exceeded 0...
April 2017: Pharmacognosy Magazine
https://www.readbyqxmd.com/read/28512133/quality-of-compounded-hydrocortisone-capsules-used-in-the-treatment-of-children
#19
Uta Neumann, Daniela Burau, Sarah Spielmann, Martin Whitaker, Richard J Ross, Charlotte Kloft, Oliver Blankenstein
Objectives: Due to the lack of paediatric licensed formulations, children are often treated with individualized pharmacy-compounded adult medication. An international web-based survey about the types of medication in children with adrenal insufficiency (AI) revealed that the majority of paediatric physicians are using pharmacy-compounded medication to treat children with AI. Observations of loss of therapy control in children with congenital adrenal hyperplasia with compounded hydrocortisone capsules and regained control after prescribing a new hydrocortisone batch led to this "real world" evaluation of pharmacy-compounded paediatric hydrocortisone capsules...
May 16, 2017: European Journal of Endocrinology
https://www.readbyqxmd.com/read/28497135/unscrambling-micro-solvation-of-cooh-and-nh-groups-in-neat-dimethyl-sulfoxide-insights-from-1-h-nmr-spectroscopy-and-computational-studies
#20
Panteleimon G Takis, Konstantinos D Papavasileiou, Loukas D Peristeras, Georgios C Boulougouris, Vasilios S Melissas, Anastassios N Troganis
Dimethyl sulfoxide (DMSO) has a significant, multi-faceted role in medicine, pharmacy, and biology as well as in biophysical chemistry and catalysis. Its physical properties and impact on biomolecular structures still attract major scientific interest, especially the interactions of DMSO with biomolecular functional groups. In the present study, we shed light on the "isolated" carboxylic (-COOH) and amide (-NH) interactions in neat DMSO via(1)H NMR studies along with extensive theoretical approaches, i.e. molecular dynamics (MD) simulations, density functional theory (DFT), and ab initio calculations, applied on model compounds (i...
May 31, 2017: Physical Chemistry Chemical Physics: PCCP
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