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https://www.readbyqxmd.com/read/29166726/-interaction-between-trpc1-and-stim1-in-calcium-sensing-receptor-mediated-calcium-influx-and-nitric-oxide-production-in-human-umbilical-vein-endothelial-cells
#1
L M Wang, H Zhong, N Tang, L J Pang, C J Zhang, F He
Objective: To investigate the interaction of Ca(2+) protein TRPC1 and STIM1 in extracellular Ca(2+) -sensing receptor (CaR)-induced extracellular Ca(2+) influx and the production of nitric oxide (NO). Methods: Human umbilical vein endothelial cells (HUVECs) were cultured and incubated with CaR agonist spermine (activating store-operates cation channels (SOC) and receptor-operated channels (ROC)), CaR negative allosteric modulator Calhex231 (blocking SOC, activating ROC) and ROC analogue TPA (activating ROC, blocking SOC), protein kinase C (PKC) inhibitor Ro31-8220, PKCs and PKCμ inhibitor Go6967(activate SOC, blocking ROC), respectively...
November 24, 2017: Zhonghua Xin Xue Guan Bing za Zhi
https://www.readbyqxmd.com/read/29166695/-without-net-and-double-floor-comparison-of-umbilical-hernia-repair-by-spitzy-in-children-and-adults
#2
Laura Kuck, Florian Seitz, Armin Wiegering, Ulrich Dietz, Thomas Meyer
Summary Umbilical hernia occur in both adults and children. For over 100 years, umbilical hernia in children has been treated surgically by the Spitzy method. With adult patients, meshes are being increasingly used. The purpose of our study was to analyse Spitzy herniotomy with respect to the recurrence rate in children and adults. Material and Methods Over a period of 7 years, 383 children (age < 16 years) with umbilical hernia were treated surgically; after applying the exclusion criteria, 370 patients were evaluated...
November 22, 2017: Zentralblatt Für Chirurgie
https://www.readbyqxmd.com/read/29166301/can-we-train-machine-learning-methods-to-outperform-the-high-dimensional-propensity-score-algorithm
#3
Mohammad Ehsanul Karim, Menglan Pang, Robert W Platt
The use of retrospective healthcare claims datasets is frequently criticized for the lack of complete information on potential confounders. Utilizing patient's health status-related information from claims datasets as surrogates or proxies for mismeasured and unobserved confounders, the high-dimensional propensity score algorithm enables us to reduce bias. Using a previously published cohort study of post-myocardial infarction statin use (1998 - 2012), we compare the performance of the algorithm with a number of popular machine learning approaches for confounder selection in high-dimensional covariate spaces: random forest, least absolute shrinkage and selection operator, and elastic net...
November 18, 2017: Epidemiology
https://www.readbyqxmd.com/read/29166224/a-reanalysis-of-occupation-and-suicide-negative-perceptions-of-the-workplace-linked-to-suicide-attempts
#4
Matt Howard, Morgan Krannitz
Suicide is the ultimate outcome of poor psychological well-being; however, there is a paucity of research examining the link between occupation and suicide, despite early academic interest and the known importance of work to our everyday lives. We propose that this body of research was abandoned prematurely, and we provide a reanalysis by integrating the Job Characteristics Model and the Conservation of Resources model with extant suicide research. Specifically, we hypothesize that work design characteristics (job autonomy, task variety, physical demands) and threats to personal resources (absence of viewing work-as-career, work-family conflict, family-work conflict, job dissatisfaction) are linked to suicide attempts via depression and suicidal ideation...
November 17, 2017: Journal of Psychology
https://www.readbyqxmd.com/read/29165469/surprisingly-high-quantum-yield-of-emission-in-a-fluorescent-coordination-polymer-with-paramagnetic-mn-ii-ions
#5
Lu Zhai, Zhu-Xi Yang, Wen-Wei Zhang, Jing-Lin Zuo, Xiao-Ming Ren
A two-dimensional coordination polymer, [Mn3(HEBTC)2(DMSO)6] (1), has been achieved by a solvothermal reaction of Mn(2+) with 1,1'-ethynebenzene-3,3',5,5'-tetracarboxylic acid (H4EBTC). The layer of a coordination polymer is composed of trinuclear Mn(2+) clusters linked by HEBTC(3-) ligands to form a (3,6)-connected topological net. CP 1 with paramagnetic Mn(2+) ions shows dual emissions centered at 397 and 468 nm in the solid state under ambient conditions with respectable quantum yields of 15.3% (397 nm) and 12...
November 22, 2017: Dalton Transactions: An International Journal of Inorganic Chemistry
https://www.readbyqxmd.com/read/29165461/synthesis-structures-and-magnetic-properties-of-two-chiral-mixed-valence-iron-ii-iii-coordination-networks
#6
Yun-Shan Xue, Xu Tan, Mengjie Zhou, Hua Mei, Yan Xu
Two rare chiral mixed-valence iron(ii,iii) coordination networks d-and l-{[Fe(II)FeO(BTC)3(DEF)3]·0.5H2O}n (d-1 and l-1) (H3BTC = 1,3,5-benzenetricarboxylic acid; DEF = N,N-diethylformamide) have been synthesized without any chiral auxiliary under the solvothermal conditions and structurally characterized by single crystal X-ray crystallography. Structural analysis indicates that these two polymers d-1 and l-1 are enantiomers. The only difference between d-1 and l-1 is that the framework of compound l-1 consists of left-handed double helical chains, while d-1 consists of right-handed double helical chains...
November 22, 2017: Dalton Transactions: An International Journal of Inorganic Chemistry
https://www.readbyqxmd.com/read/29165350/large-scale-analysis-of-antimicrobial-activities-in-relation-to-amphipathicity-and-charge-reveals-novel-characterization-of-antimicrobial-peptides
#7
Chien-Kuo Wang, Ling-Yi Shih, Kuan Y Chang
It has been unclear to which antimicrobial activities (e.g., anti-gram-positive bacterial, anti-gram-negative bacterial, antifungal, antiparasitic, and antiviral activities) of antimicrobial peptides (AMPs) a given physiochemical property matters most. This is the first computational study using large-scale AMPs to examine the relationships between antimicrobial activities and two major physiochemical properties of AMPs-amphipathicity and net charge. The results showed that among all kinds of antimicrobial activities, amphipathicity and net charge best differentiated between AMPs with and without anti-gram-negative bacterial activities...
November 22, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/29165098/effects-of-olive-oil-on-tnf-%C3%AE-and-il-6-in-humans-implication-in-obesity-and-frailty
#8
Nagendra Sastry Yarla, Angela Polito, Ilaria Peluso
BACKGROUND AND OBJECTIVE: Tumor necrosis factor-alpha (TNF)-α and interleukin (IL)-6 are important mediators of chronic low-grade systemic inflammation. The latter plays a central role in several obesity-related pathologies, such as diabetes, metabolic syndrome and cardiovascular diseases. Besides, these cytokines have been also implicated in geriatric and cancer-induced anorexia, cachexia, sarcopenia and frailty. Potential interventions for both obesity and frailty include dietary advice and nutraceuticals...
November 20, 2017: Endocrine, Metabolic & Immune Disorders Drug Targets
https://www.readbyqxmd.com/read/29165093/a-randomized-double-blind-placebo-controlled-crossover-study-to-assess-the-safety-and-beneficial-effects-of-cassia-tora-supplementation-in-healthy-adults
#9
Himavanth Reddy Kambalachenu, Thandlam Muneeswa Reddy, Sirpurkar Dattatreya Rao, Kambalachenu Dorababu, Kanala Kodanda Reddy, Kvs Sarma
OBJECTIVE: The current clinical trial was aimed at evaluating the safety and beneficial effect of Cassia tora (C.tora) supplementation in healthy adults. DESIGN: A randomized, double blind, placebo controlled study with a crossover design was done on 60 healthy normal weight adults (age range: 20-55 yrs). The study consisted of 2 treatment phases of 24 weeks each with a washout period of 4 weeks between the phases. 30 subjects randomly allocated to the 'Placebo first' group and 30 to 'C...
November 19, 2017: Reviews on Recent Clinical Trials
https://www.readbyqxmd.com/read/29164963/amorphous-silica-nanoparticles-induce-malignant-transformation-and-tumorigenesis-of-human-lung-epithelial-cells-via-p53-signaling
#10
Caixia Guo, Ji Wang, Man Yang, Yang Li, Shuxiang Cui, Xianqing Zhou, Yanbo Li, Zhiwei Sun
Rapid development and deployment of engineered nanomaterials, such as amorphous silica nanoparticles (SiNPs) in various commercial and biomedical applications have raised concerns about their potential adverse health effects, especially their chronic effects which have not been well addressed. In this study, human lung epithelial cells, BEAS-2B were continuously exposed to amorphous SiNPs, 5 μg/mL for 40 passages. We demonstrated here that prolonged exposure of BEAS-2B cells to amorphous SiNPs induced malignant transformation as indicated by enhanced cellular proliferation, anchorage-independent cell growth, and increased cell migration...
November 22, 2017: Nanotoxicology
https://www.readbyqxmd.com/read/29164628/technical-note-response-time-evolution-of-xr-qa2-gafchromic-tm-film-models
#11
Saad Aldelaijan, Nada Tomic, Pavlos Papaconstadopoulos, James Schneider, Jan Seuntjens, Shelley Shih, David Lewis, Slobodan Devic
PURPOSE: To evaluate the response of the newest XR-QA2 GafChromic(™) film model in terms of post-exposure signal growth and energy response in comparison with the older XR-QA (Version 2) model. METHODS: Pieces of film were irradiated to air kerma in air values up to 12 cGy with several beam qualities (5.3-8.25 mm Al) commonly used for CT scanning. Film response was scored in terms of net reflectance from scanned film images at various points in time post-irradiation ranging from 1 to 7 days and 5 months post exposure...
November 22, 2017: Medical Physics
https://www.readbyqxmd.com/read/29163947/mechanical-diagnosis-and-therapy-enhances-attitude-toward-self-management-in-people-with-musculoskeletal-disorders-a-preliminary-evidence-with-a-before-after-design
#12
Hiroshi Takasaki
Objectives: Mechanical diagnosis and therapy is one of the most common approaches for the management of low back pain. In mechanical diagnosis and therapy, a great emphasis is placed on patient education so that patients can manage their problems by themselves. However, there has been no evidence that mechanical diagnosis and therapy actually enhances patient's self-management skills. This study aimed to preliminarily investigate whether self-reported skills of self-management for musculoskeletal problems are enhanced through the course of mechanical diagnosis and therapy...
2017: SAGE Open Medicine
https://www.readbyqxmd.com/read/29163929/nickel-catalyzed-transamidation-of-aliphatic-amide-derivatives
#13
Jacob E Dander, Emma L Baker, Neil K Garg
Transamidation, or the conversion of one amide to another, is a long-standing challenge in organic synthesis. Although notable progress has been made in the transamidation of primary amides, the transamidation of secondary amides has remained underdeveloped, especially when considering aliphatic substrates. Herein, we report a two-step approach to achieve the transamidation of secondary aliphatic amides, which relies on non-precious metal catalysis. The method involves initial Boc-functionalization of secondary amide substrates to weaken the amide C-N bond...
September 1, 2017: Chemical Science
https://www.readbyqxmd.com/read/29163839/prognostic-value-of-intratumoral-metabolic-heterogeneity-on-f-18-fluorodeoxyglucose-positron-emission-tomography-computed-tomography-in-locally-advanced-cervical-cancer-patients-treated-with-concurrent-chemoradiotherapy
#14
Gun Oh Chong, Won Kee Lee, Shin Young Jeong, Shin-Hyung Park, Yoon Hee Lee, Sang-Woo Lee, Dae Gy Hong, Jae-Chul Kim, Yoon Soon Lee
Objective: To evaluate the prognostic value for predicting tumor recurrence of intratumoral metabolic heterogeneity and traditional quantitative metabolic parameters on pre-treatment F-18-fluorodeoxyglucose positron emission tomography/computed tomography (18F-FDG PET/CT) in patients with locally advanced cervical cancer treated with concurrent chemoradiotherapy (CCRT). Materials and Methods: Ninety-three patients with biopsy-proven cervical cancer and treated with CCRT (FIGO stage IIB-IV) were enrolled in this study...
October 27, 2017: Oncotarget
https://www.readbyqxmd.com/read/29163624/phytohormone-and-light-regulation-of-chlorophyll-degradation
#15
REVIEW
Xiaoyu Zhu, Junyi Chen, Kai Qiu, Benke Kuai
Degreening, due to the net loss of chlorophyll (Chl), is the most prominent symptom during the processes of leaf senescence, fruit ripening, and seed maturation. Over the last decade or so, extensive identifications of Chl catabolic genes (CCGs) have led to the revelation of the biochemical pathway of Chl degradation. As such, exploration of the regulatory mechanism of the degreening process is greatly facilitated. During the past few years, substantial progress has been made in elucidating the regulation of Chl degradation, particularly via the mediation of major phytohormones' signaling...
2017: Frontiers in Plant Science
https://www.readbyqxmd.com/read/29163602/effects-of-ridge-furrow-system-combined-with-different-degradable-mulching-materials-on-soil-water-conservation-and-crop-production-in-semi-humid-areas-of-china
#16
Xiaolong Ren, Xiaoli Chen, Tie Cai, Ting Wei, Yang Wu, Shahzad Ali, Peng Zhang, Zhikuan Jia
In China, the ridge-furrow water conservation planting (RC) system is advantageous for improving crop yields and rainwater use efficiency. In RC planting system, plastic film-mulched ridges are employed for water harvesting while the furrows serve as infiltration and planting belts. To optimize the RC system and to overcome problems due to the lack of water in semi-humid areas at risk of drought, we mulched the furrows with 8% biodegradable film (RCSB), liquid film (RCSL), or no mulching in the furrows (RCSN), while conventional flat planting (CF) was employed as the control...
2017: Frontiers in Plant Science
https://www.readbyqxmd.com/read/29163192/cycling-before-and-after-exhaustion-differently-affects-cardiac-autonomic-control-during-heart-rate-matched-exercise
#17
Matthias Weippert, Martin Behrens, Anett Mau-Moeller, Sven Bruhn, Kristin Behrens
During cycling before (PRE) and after exhaustion (POST) different modes of autonomic cardiac control might occur due to different interoceptive input and altered influences from higher brain centers. We hypothesized that heart rate variability (HRV) is significantly affected by an interaction of the experimental period (PRE vs. POST) and exercise intensity (HIGH vs. LOW; HIGH = HR > HR at the lactate threshold (HRLT), LOW = HR ≤ HRLT) despite identical average HR. Methods: Fifty healthy volunteers completed an incremental cycling test until exhaustion...
2017: Frontiers in Physiology
https://www.readbyqxmd.com/read/29163078/natural-translating-locomotion-modulates-cortical-activity-at-action-observation
#18
Thierry Pozzo, Alberto Inuggi, Alejo Keuroghlanian, Stefano Panzeri, Ghislain Saunier, Claudio Campus
The present study verified if the translational component of locomotion modulated cortical activity recorded at action observation. Previous studies focusing on visual processing of biological motion mainly presented point light walker that were fixed on a spot, thus removing the net translation toward a goal that yet remains a critical feature of locomotor behavior. We hypothesized that if biological motion recognition relies on the transformation of seeing in doing and its expected sensory consequences, a significant effect of translation compared to centered displays on sensorimotor cortical activity is expected...
2017: Frontiers in Systems Neuroscience
https://www.readbyqxmd.com/read/29162745/does-sympathetic-dysfunction-occur-before-denervation-in-pure-autonomic-failure
#19
Ling Guo, Murray D Esler, Carolina Sari, Sarah Phillips, Elisabeth A Lambert, Nora E Straznicky, Gavin W Lambert, Susan J Corcoran
BACKGROUND: Pure autonomic failure (PAF) is a rare sporadic disorder characterised by autonomic failure in the absence of a movement disorder or dementia and is associated with very low plasma norepinephrine levels - suggesting widespread sympathetic denervation, however the underlying pathology remains poorly elucidated. We sought to correlate clinical and neurochemical findings with sympathetic nerve protein abundances, accessed by way of a forearm vein biopsy, in patients with PAF and in healthy controls and patients with multiple systems atrophy (MSA) in whom sympathetic nerves are considered intact...
November 21, 2017: Clinical Science (1979-)
https://www.readbyqxmd.com/read/29162603/exogenous-insulin-infusion-can-decrease-atherosclerosis-in-diabetic-rodents-by-improving-lipids-inflammation-and-endothelial-function
#20
Kyoungmin Park, Qian Li, Net Daş Evcimen, Christian Rask-Madsen, Yasutaka Maeda, Ernesto Maddaloni, Hisashi Yokomizo, Takanori Shinjo, Ronald St-Louis, Jialin Fu, Daniel Gordin, Mogher Khamaisi, David Pober, Hillary Keenan, George L King
OBJECTIVE: The objective of this study is to evaluate whether exogenously induced hyperinsulinemia may increase the development of atherosclerosis. APPROACH AND RESULTS: Hyperinsulinemia, induced by exogenous insulin implantation in high-fat fed (60% fat HFD) apolipoprotein E-deficient mice (ApoE(-/-)) mice, exhibited insulin resistance, hyperglycemia, and hyperinsulinemia. Atherosclerosis was measured by the accumulation of fat, macrophage, and extracellular matrix in the aorta...
November 21, 2017: Arteriosclerosis, Thrombosis, and Vascular Biology
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