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https://www.readbyqxmd.com/read/28549315/associations-between-the-levels-of-thyroid-hormones-and-lipid-lipoprotein-levels-data-from-national-health-and-nutrition-examination-survey-2007-2012
#1
Ram B Jain
Data from National Health and Nutrition Examination Survey for the years 2007-2012 were used to investigate associations between thyroid hormones and lipid/lipoprotein levels for a representative sample of general US population aged ≥20 years. There were no statistically significant differences for adjusted high density lipoprotein levels among thyroid function groups, namely, subclinical hyperthyroid (SCHPR), clinical hyperthyroid (CHPR), euthyroid (EU), clinical hypothyroid (CHYP), and subclinical hypothyroid (SCHYP)...
May 4, 2017: Environmental Toxicology and Pharmacology
https://www.readbyqxmd.com/read/28548974/remnant-lipoproteins
#2
Anette Varbo, Børge G Nordestgaard
PURPOSE OF REVIEW: To review recent advances in the field of remnant lipoproteins and remnant cholesterol with a focus on cardiovascular disease risk. RECENT FINDINGS: In line with previous years' research, current observational, genetic, and mechanistic studies find remnant lipoproteins (defined in different ways) to be involved in atherosclerosis development and cardiovascular disease risk. High concentrations of remnant cholesterol could explain some of the residual risk of cardiovascular disease seen after LDL cholesterol lowering...
May 25, 2017: Current Opinion in Lipidology
https://www.readbyqxmd.com/read/28548560/microalgal-oil-from-schizochytrium-sp-prevents-hfd-induced-abdominal-fat-accumulation-in-mice
#3
Jinhui Yu, Yong Ma, Jie Sun, Liyuan Ran, Youwei Li, Ning Wang, Tao Yu, Wenting Gao, Wenbin Jia, Rujiao Jiang, Meihua Guo, Yuping Bi, Yingjie Wu
OBJECTIVE: Dietary n-3 polyunsaturated fatty acids (PUFAs), especially eicosapentaenoic acids (EPA) and docosahexaenoic acid (DHA), are proved to be effective in obesity reduction. Microalgal oil (MO) is an important alternative source of n-3 PUFAs that effectively alleviates obesity. The aim of the present study was to explore the anti-obesity effects of microalgal oil from Schizochytrium sp. (SMO) and to compare the effects of 2 SMOs (SMO1 and SMO2) with different levels of purity of n-3 PUFAs on high fat diet (HFD)-induced obesity in male C57BL/6J mice...
May 26, 2017: Journal of the American College of Nutrition
https://www.readbyqxmd.com/read/28547184/combination-of-magnetic-dispersive-micro-solid-phase-extraction-and-supramolecular-solvent-based-microextraction-followed-by-high-performance-liquid-chromatography-for-determination-of-trace-amounts-of-cholesterol-lowering-drugs-in-complicated-matrices
#4
Somayeh Arghavani-Beydokhti, Maryam Rajabi, Alireza Asghari
A novel, efficient, rapid, simple, sensitive, selective, and environmentally friendly method termed magnetic dispersive micro solid-phase extraction combined with supramolecular solvent-based microextraction (Mdμ-SPE-SSME) followed by high-performance liquid chromatography (HPLC) with UV detection is introduced for the simultaneous microextraction of cholesterol-lowering drugs in complicated matrices. In the first microextraction procedure, using layered double hydroxide (LDH)-coated Fe3O4 magnetic nanoparticles, an efficient sample cleanup is simply and rapidly provided without the need for time-consuming centrifugation and elution steps...
May 26, 2017: Analytical and Bioanalytical Chemistry
https://www.readbyqxmd.com/read/28546848/estimation-of-maximal-oxygen-consumption-and-heart-rate-recovery-using-the-tecumseh-sub-maximal-step-test-and-their-relationship-to-cardiovascular-risk-factors
#5
Alun D Hughes, Nish Chaturvedi
BACKGROUND: Maximum aerobic capacity (VO2max) is associated with lower cardiovascular and total mortality. Step tests can be used to provide an estimate of (VO2max) in epidemiological or home-based studies. We compared different methods of estimation of VO2max and heart rate recovery and evaluated the relationship of these estimates with cardiovascular risk factors. METHODS: Data were analysed from 2286 participants in the Tecumseh Community Health Study (>16y and <70y) who performed a step test...
June 2017: Artery Research
https://www.readbyqxmd.com/read/28546421/statins-attenuate-activation-of-the-nlrp3-inflammasome-by-oxidized-ldl-or-tnf-%C3%AE-in-vascular-endothelial-cells-through-a-pxr-dependent-mechanism
#6
Shaolan Wang, Xinya Xie, Ting Lei, Kang Zhang, Baochang Lai, Zihui Zhang, Youfei Guan, Guangmei Mao, Lei Xiao, Nanping Wang
Excessive activation of the NLRP3 inflammasome is implicated in cardiovascular diseases. Statins exert an anti-inflammatory effect independent of their cholesterol lowering effect. This study investigated the potential role of statins in the activation of the NLRP3 inflammasome in endothelial cells (ECs). Western blotting and qRT-PCR showed that oxidized-LDL (oxLDL) or tumor necrosis factor alpha (TNFα) activated the NLRP3 inflammasome in ECs. Simvastatin or mevastatin significantly suppressed the effects of oxLDL or TNFα...
May 25, 2017: Molecular Pharmacology
https://www.readbyqxmd.com/read/28546217/increased-hepatic-expression-of-endothelial-lipase-inhibits-cholesterol-diet-induced-hypercholesterolemia-and-atherosclerosis-in-transgenic-rabbits
#7
Chuan Wang, Kazutoshi Nishijima, Shuji Kitajima, Manabu Niimi, Haizhao Yan, Yajie Chen, Bo Ning, Fumikazu Matsuhisa, Enqi Liu, Jifeng Zhang, Y Eugene Chen, Jianglin Fan
OBJECTIVE: Endothelial lipase (EL) is a key determinant in plasma high-density lipoprotein-cholesterol. However, functional roles of EL on the development of atherosclerosis have not been clarified. We investigated whether hepatic expression of EL affects plasma lipoprotein metabolism and cholesterol diet-induced atherosclerosis. APPROACH AND RESULTS: We generated transgenic (Tg) rabbits expressing the human EL gene in the liver and then examined the effects of EL expression on plasma lipids and lipoproteins and compared the susceptibility of Tg rabbits with cholesterol diet-induced atherosclerosis with non-Tg littermates...
May 25, 2017: Arteriosclerosis, Thrombosis, and Vascular Biology
https://www.readbyqxmd.com/read/28545518/design-and-rationale-of-the-odyssey-dm-dyslipidemia-trial-lipid-lowering-efficacy-and-safety-of-alirocumab-in-individuals-with-type-2-diabetes-and-mixed-dyslipidaemia-at-high-cardiovascular-risk
#8
Dirk Müller-Wieland, Lawrence A Leiter, Bertrand Cariou, Alexia Letierce, Helen M Colhoun, Stefano Del Prato, Robert R Henry, Francisco J Tinahones, Lisa Aurand, Jaman Maroni, Kausik K Ray, Maja Bujas-Bobanovic
BACKGROUND: Type 2 diabetes mellitus (T2DM) is often associated with mixed dyslipidaemia, where non-high-density lipoprotein cholesterol (non-HDL-C) levels may more closely align with cardiovascular risk than low-density lipoprotein cholesterol (LDL-C). We describe the design and rationale of the ODYSSEY DM-DYSLIPIDEMIA study that assesses the efficacy and safety of alirocumab, a proprotein convertase subtilisin/kexin type 9 (PCSK9) inhibitor, versus lipid-lowering usual care in individuals with T2DM and mixed dyslipidaemia at high cardiovascular risk with non-HDL-C inadequately controlled despite maximally tolerated statin therapy...
May 25, 2017: Cardiovascular Diabetology
https://www.readbyqxmd.com/read/28545089/the-dynamic-behaviour-of-metabolic-syndrome-and-its-components-in-an-eight-year-population-based-cohort-from-the-mediterranean
#9
Maria A Barceló, Antonio Rodríguez-Poncelas, Marc Saez, Gabriel Coll-de-Tuero
BACKGROUND: The significant rise in the prevalence of obesity coincides with the considerable increase in the prevalence of metabolic syndrome (MS) currently being observed worldwide. The components of MS are not static and their dynamics, such as the order of their occurrence, or the time of exposure to them are, as yet, unknown but could well be clinically relevant. Our objective was to study the dynamic behaviour of MS and its components in a large population-based cohort from a Mediterranean region...
2017: PloS One
https://www.readbyqxmd.com/read/28543362/commd1-a-multifunctional-regulatory-protein
#10
Mario Riera Romo
The COMMD Protein Family is highly conserved among multicellular eukaryotic organisms and many orthologs of human COMMD genes have been found in different species of plants, invertebrates, lower vertebrates and mammals. COMMD1 is the best characterized member of the family and is conserved among vertebrates. This protein represents a pleiotropic factor involved in the regulation of many cellular and physiological processes that include copper and cholesterol homeostasis, ionic transport, oxidative stress, protein aggregation, protein trafficking, NF-κB-mediated transcription, hypoxia induced transcription, DNA damage response and oncogenesis...
May 20, 2017: Journal of Cellular Biochemistry
https://www.readbyqxmd.com/read/28542805/downregulation-of-cholesteryl-ester-transfer-protein-by-glucocorticoids-a-randomized-study-on-hdl
#11
Jorien Werumeus Buning, Lidya G Dimova, Frank G Perton, Uwe J F Tietge, André P van Beek, Robin P F Dullaart
BACKGROUND: High density lipoprotein (HDL) cholesterol is not decreased in hypercortisolism despite high triglycerides, which may be ascribed to effects on the cholesteryl ester transfer protein (CETP) pathway. We explored if CETP mRNA expression is modulated by glucocorticoid treatment in vitro. Effects of doubling the hydrocortisone (HCT) replacement dose on plasma CETP activity and HDL characteristics were tested in patients with secondary adrenal insufficiency. MATERIALS AND METHODS: Human THP-1 macrophages were incubated with corticosterone in vitro in the presence or absence of a liver X receptor (LXR) agonist, followed by determination of CETP mRNA levels by quantitative real-time PCR...
May 24, 2017: European Journal of Clinical Investigation
https://www.readbyqxmd.com/read/28542128/hmg-coa-reductase-promotes-protein-prenylation-and-therefore-is-indispensible-for-t-cell-survival
#12
Sonja M Lacher, Julia Bruttger, Bettina Kalt, Jean Berthelet, Krishnaraj Rajalingam, Simone Wörtge, Ari Waisman
Statins are a well-established family of drugs that lower cholesterol levels via the competitive inhibition of the enzyme 3-hydroxy-3-methylglutaryl coenzyme A reductase (HMGCR). In addition, the pleiotropic anti-inflammatory effects of statins on T cells make them attractive as therapeutic drugs in T-cell-driven autoimmune disorders. Since statins do not exclusively target HMGCR and thus might have varying effects on different cell types, we generated a new mouse strain allowing for the tissue-specific deletion of HMGCR...
May 25, 2017: Cell Death & Disease
https://www.readbyqxmd.com/read/28540870/atorvastatin-as-adjunctive-therapy-for-chronic-plaque-type-psoriasis-versus-betamethasone-valerate-alone-a-randomized-double-blind-placebo-controlled-trial
#13
Sharlene Helene H Chua, Giselle Marie S Tioleco, Carmela Augusta F Dayrit, Winlove P Mojica, Belen L Dofitas, Lorna F Frez
BACKGROUND: Psoriasis is a T helper 1 cell-mediated chronic inflammation. Statins have been found to have anti-inflammatory and immunomodulatory effects targeting T helper 1 cells and thus, are being investigated as treatments for psoriasis. AIMS: To investigate the efficacy and safety of atorvastatin as adjunctive treatment for mild to moderate chronic plaque psoriasis; and the impact of atorvastatin on quality of life. The study also aimed to correlate the beneficial effects of atorvastatin with its lipid-lowering effects...
May 23, 2017: Indian Journal of Dermatology, Venereology and Leprology
https://www.readbyqxmd.com/read/28540139/prevalence-of-high-risk-cardiovascular-patients-with-therapy-resistant-hypercholesterolemia
#14
Karel Kostev, Klaus G Parhofer, Franz-Werner Dippel
INTRODUCTION: Hypercholesterolemia is a causal risk factor for cardiovascular diseases, which is recommended to be treated at least in high-risk patients. Yet, currently there is a lack of epidemiological data on the number of high-risk patients in Germany who do not respond adequately to high-dose statin monotherapy or statin therapy in combination with other lipid-lowering agents. METHODS: Of a total of over 2.6 million patient records from general practitioners in the IMS Disease Analyzer database, all high-risk cardiovascular patients with hypercholesterolemia who did not reach target low-density lipoprotein-cholesterol (LDL-C) levels despite at least 12 months of maximum lipid-lowering therapy and optimal medication supply (medication possession rate≥80%) were selected over a defined period...
June 2017: Cardiovascular Endocrinology
https://www.readbyqxmd.com/read/28539955/an-inter-ethnic-comparison-study-of-ziprasidone-plasma-levels-dosage-and-clinical-response-in-patients-with-schizophrenia
#15
Dongsheng Lv, Meirong Zhao, Lixia Chen, Dongsheng Yu, Xiaobin Yun, Qing Yang, Xiaojun Huang
OBJECTIVE: The aim of this study was to investigate ziprasidone plasma concentration, daily dose and clinical efficacy and safety in Han Chinese and Mongolian patients with first-episode schizophrenia. METHODS: A total of 123 inpatients affected by schizophrenia were recruited from the Mental Health Center of Inner Mongolia in China. Ziprasidone plasma concentration, clinical efficacy and side effects were systematically evaluated at baseline, and at 1, 2, 4, and 6 weeks...
May 2017: Psychiatry Investigation
https://www.readbyqxmd.com/read/28539743/hepatoprotective-antihyperlipidemic-and-anti-inflammatory-activity-of-moringa-oleifera-in-diabetic-induced-damage-in-male-wistar-rats
#16
Elizabeth I Omodanisi, Yapo G Aboua, Novel N Chegou, Oluwafemi O Oguntibeju
BACKGROUND: The number of individuals with diabetes is increasing daily, and diabetes is presently estimated to affect about 422 million adults worldwide. Conventional drugs used to treat diabetes are not without severe side effects, accessibility, and affordability. This study elucidates the potential effects of Moringa oleifera (MO) leaves extract to manage and treat diabetes induced in male Wistar rats. MATERIALS AND METHODS: Adult male Wistar rats were randomly divided into four groups (n = 12/group): NC - nondiabetic rats (positive control), MO - nondiabetic-treated rats, DM - diabetic rats (negative control), DM + MO - diabetic-treated rats...
April 2017: Pharmacognosy Research
https://www.readbyqxmd.com/read/28539740/evaluation-of-antioxidant-hypolipidemic-and-antiatherogenic-property-of-lycopene-and-astaxanthin-in-atherosclerosis-induced-rats
#17
Rajesh Kumar, Kartik Janardan Salwe, Manimekalai Kumarappan
BACKGROUND: Atherosclerosis is one of the major causes of morbidity and mortality in the world. Antioxidants play a major role in prophylaxis and prevention of progression and complications of atherosclerosis. OBJECTIVE: In this study, we are evaluating the antiatherosclerotic effect of two antioxidants such as astaxanthin and lycopene. MATERIALS AND METHODS: After acclimatization, 24 male SD rats, 8-10 weeks old, 150 ± 10 g, maintained as per CPCSEA guidelines were divided into four groups of six rats each...
April 2017: Pharmacognosy Research
https://www.readbyqxmd.com/read/28539572/malondialdehyde-modified-low-density-lipoprotein-as-oxidative-stress-marker-in-vasospastic-angina-patients
#18
Tetsuo Oumi, Toshihiro Nozato, Atsushi Sakakibara, Hidetsugu Nomoto, Masakazu Ohno, Yoshihide Takahashi, Takashi Ashikaga, Yasuhiro Satoh, Mitsuaki Isobe
Vasospastic angina (VSA) is caused by endothelial dysfunction and hypercontraction of vascular smooth muscle cells. Although oxidative-stress can induce endothelial dysfunction, the relationship of VSA and the oxidative-stress marker malondialdehyde-modified low density lipoprotein (MDA-LDL) remains unclear. PURPOSE: Serum MDA-LDL was evaluated in candidate VSA patients.The subjects were 84 patients admitted to our hospital because of chest pain at rest. We stratified the patients into 3 groups; definite VSA, suspected VSA, and unlikely VSA according to a Japanese Circulation Society (JCS) guideline...
May 23, 2017: International Heart Journal
https://www.readbyqxmd.com/read/28539539/efficacy-and-safety-of-bococizumab-rn316-pf-04950615-a-monoclonal-antibody-against-proprotein-convertase-subtilisin-kexin-type-9-in-hypercholesterolemic-japanese-subjects-receiving-a-stable-dose-of-atorvastatin-or-treatment-naive%C3%A3-results-from-a-randomized
#19
Koutaro Yokote, Shigeto Kanada, Osamu Matsuoka, Hisakuni Sekino, Keiji Imai, Junichi Tabira, Nobushige Matsuoka, Sandip Chaudhuri, Tamio Teramoto
BACKGROUND: A Phase 2, dose-ranging study of bococizumab, a monoclonal anti-proprotein convertase subtilisin/kexin type 9 antibody, was conducted in Japanese subjects to assess its efficacy, safety, and tolerability in this population.Methods and Results:Two different hypercholesterolemic study populations were enrolled concurrently: Japanese subjects with uncontrolled low-density lipoprotein cholesterol (LDL-C) despite atorvastatin treatment (LDL-C ≥100 mg/dL; n=121), and Japanese subjects naive to lipid-lowering agents and with LDL-C ≥130 mg/dL (n=97)...
May 23, 2017: Circulation Journal: Official Journal of the Japanese Circulation Society
https://www.readbyqxmd.com/read/28539258/dietary-approaches-to-stop-hypertension-diet-weight-status-and-blood-pressure-among-children-and-adolescents-national-health-and-nutrition-examination-surveys-2003-2012
#20
Juliana F W Cohen, Megan E Lehnerd, Robert F Houser, Eric B Rimm
BACKGROUND: The Dietary Approaches to Stop Hypertension (DASH) diet is associated with lower blood pressure and reduced risk of cardiovascular disease among adults, but little is known about accordance with this dietary pattern or health benefits among children and adolescents. OBJECTIVE: The objectives were to evaluate accordance with the DASH diet, differences over time, and the association with health attributes among a nationally representative sample of US children and adolescents...
May 20, 2017: Journal of the Academy of Nutrition and Dietetics
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