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Impaired glucose tolerance

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https://www.readbyqxmd.com/read/28920721/-changes-in-carbohydrate-metabolism-after-kidney-transplantation-and-their-effects-on-cardiovascular-risk
#1
Bernadett Borda, Edit Szederkényi, Zoltán Hódi, Aurél Ottlakán, Viktor Szabó, György Lázár
INTRODUCTION: Cardiovascular disease is the major cause of deaths after transplantation, with diabetes mellitus being the main risk factor in development. AIM: The aim of our study was to assess the prevalence of new onset diabetes mellitus in connection with the cardiovascular risk predicted by the HEART Score. METHOD: 44 patients were involved in our study; after overview of baseline data, OGTT was performed, followed by patient classification into the following groups: normal, impaired fasting glucose/impaired glucose tolerance, and new onset diabetes mellitus...
September 2017: Orvosi Hetilap
https://www.readbyqxmd.com/read/28919580/concomitant-obesity-and-metabolic-syndrome-add-to-the-atrial-arrhythmogenic-phenotype-in-male-hypertensive-rats
#2
Mathias Hohl, Dennis H Lau, Andreas Müller, Adrian D Elliott, Benedikt Linz, Rajiv Mahajan, Jeroen M L Hendriks, Michael Böhm, Ulrich Schotten, Prashanthan Sanders, Dominik Linz
BACKGROUND: Besides hypertension, obesity and the metabolic syndrome have recently emerged as risk factors for atrial fibrillation. This study sought to delineate the development of an arrhythmogenic substrate for atrial fibrillation in hypertension with and without concomitant obesity and metabolic syndrome. METHODS AND RESULTS: We compared obese spontaneously hypertensive rats (SHR-obese, n=7-10) with lean hypertensive controls (SHR-lean, n=7-10) and normotensive rats (n=7-10)...
September 17, 2017: Journal of the American Heart Association
https://www.readbyqxmd.com/read/28917545/effects-of-acarbose-on-cardiovascular-and-diabetes-outcomes-in-patients-with-coronary-heart-disease-and-impaired-glucose-tolerance-ace-a-randomised-double-blind-placebo-controlled-trial
#3
Rury R Holman, Ruth L Coleman, Juliana C N Chan, Jean-Louis Chiasson, Huimei Feng, Junbo Ge, Hertzel C Gerstein, Richard Gray, Yong Huo, Zhihui Lang, John J McMurray, Lars Rydén, Stefan Schröder, Yihong Sun, Michael J Theodorakis, Michal Tendera, Lynne Tucker, Jaakko Tuomilehto, Yidong Wei, Wenying Yang, Duolao Wang, Dayi Hu, Changyu Pan
BACKGROUND: The effect of the α-glucosidase inhibitor acarbose on cardiovascular outcomes in patients with coronary heart disease and impaired glucose tolerance is unknown. We aimed to assess whether acarbose could reduce the frequency of cardiovascular events in Chinese patients with established coronary heart disease and impaired glucose tolerance, and whether the incidence of type 2 diabetes could be reduced. METHODS: The Acarbose Cardiovascular Evaluation (ACE) trial was a randomised, double-blind, placebo-controlled, phase 4 trial, with patients recruited from 176 hospital outpatient clinics in China...
September 12, 2017: Lancet Diabetes & Endocrinology
https://www.readbyqxmd.com/read/28917079/insulin-autoimmune-syndrome-hirata-s-disease-in-an-italian-patient-a-case-report-and-review-of-the-literature
#4
REVIEW
Simona Censi, Maria Paola Albergoni, Nicoletta Gallo, Mario Plebani, Marco Boscaro, Corrado Betterle
We describe the case of a 54-year-old Caucasian Italian male experiencing episodes of hypoglycemia, occurring mainly after meals. He had never been exposed to insulin and was taking ramipril, flecainide and acetylsalicylic acid. An oral glucose tolerance test (OGTT) showed high blood glucose levels diagnostic for diabetes mellitus at 120 min and hypoglycemia with inappropriately high insulin levels at 240 min. The 72-h fasting test, abdominal computed tomography (CT) and positron emission tomography-CT were normal...
September 16, 2017: Clinical Chemistry and Laboratory Medicine: CCLM
https://www.readbyqxmd.com/read/28916170/the-1h-post-glucose-value-best-predicts-future-dysglycemia-among-normal-glucose-tolerance-subjects
#5
Narasimmal Sai Prasanna, Anandakumar Amutha, Thyparambil Aravindakshan Pramodkumar, Ranjit Mohan Anjana, Ulagamathesan Venkatesan, Miranda Priya, Rajendra Pradeepa, Viswanathan Mohan
AIM: To analyse the OGTT glycemic parameters - fasting, 1h and 2h plasma glucose values singly and in various combinations; with respect to their prediction of future dysglycemia in subjects with normal glucose tolerance (NGT). METHODS: Electronic medical records of individuals who underwent an OGTT between 1991 and 2016 at a tertiary diabetes centre were analysed. NGT subjects who had at least one more follow up OGTT (n=1356) were selected for the study. Regarding their prediction of future dysglycemia, the glycemic parameters-Fasting plasma glucose (FPG), 1h plasma glucose (1HrPG) and 2h plasma glucose (2HrPG) were analysed separately and also in different combinations...
August 1, 2017: Journal of Diabetes and its Complications
https://www.readbyqxmd.com/read/28915786/nutrition-in-primary-and-secondary-prevention-of-cardiovascular-risk-in-the-continental-and-mediterranean-regions-of-croatia
#6
Jozica Sikic, Mira Stipcevic, Hrvoje Vrazic, Jasna Cerkez Habek, Eduard Margetic, Dario Gulin
BACKGROUND: The aim of this observational study was to evaluate the effect of Mediterranean and continental nutrition on cardiovascular risk in patients with acute and chronic coronary heart disease in Croatia. METHODS: The study included 1284 patients who were hospitalized in a 28-month period due to acute or chronic ischaemic heart disease in hospitals across Croatia. An individual questionnaire was prepared which enabled recording of various cardiovascular risk factors...
September 16, 2017: BMC Cardiovascular Disorders
https://www.readbyqxmd.com/read/28912863/a-novel-mutation-in-the-hepatocyte-nuclear-factor-1%C3%AE-gene-in-maturity-onset-diabetes-of-the-young-5-with-multiple-renal-cysts-and-pancreas-hypogenesis-a-case-report
#7
You Lv, Zhuo Li, Kan He, Ying Gao, Xianchao Xiao, Yujia Liu, Guixia Wang
A 17-year-old Chinese male was hospitalized exhibiting hyperglycemia and increased serum urea nitrogen and creatinine levels in addition to weight loss. The patient was treated with gliclazide. The patient was 150 cm tall, weighed 35 kg and had no family history of diabetes or kidney disease. Physical examination revealed cephalus quadratus, rachitic rosary and a visible toe-out gait. Laboratory examinations revealed that the patient's fasting plasma glucose and glycosylated hemoglobin levels were markedly increased, fasting plasma C-peptide level was slightly increased and no peak 2 h postprandial was observed...
October 2017: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/28911865/3-2-amino-ethyl-5-3-4-butoxyl-phenyl-propylidene-thiazolidine-2-4-dione-k145-ameliorated-dexamethasone-induced-hepatic-gluconeogenesis-through-activation-of-akt-foxo1-pathway
#8
Yanan Shi, Jiayun Qiao, Biao Mu, Bingfeng Zuo, Jihong Yuan
3-(2-amino-ethyl)-5-[3-(4-butoxyl-phenyl)-propylidene]-thiazolidine-2,4-dione (K145) is identified as a selective SphK2 inhibitor. It was previously reported as an anti-tumor agent, in this study we demonstrated that K145 was able to regulate hepatic gluconeogenesis and improve glucose intolerance in mice. C57BL/6 mice treated with dexamethasone injection were used as experimental animals, which exhibited impaired glucose tolerance and increased gluconeogenetic enzymes. After K145 treatment, we found that the impairment of glucose tolerance and gluconeogenetic genes mRNA expression were improved...
September 11, 2017: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/28911640/long-term-feeding-of-red-algae-gelidium-amansii-ameliorates-glucose-and-lipid-metabolism-in-a-high-fructose-diet-impaired-glucose-tolerance-rat-model
#9
Hshuan-Chen Liu, Chun-Ju Chang, Tsung-Han Yang, Meng-Tsan Chiang
This study was designed to investigate the effect of Gelidium amansii (GA) on carbohydrate and lipid metabolism in rats with high fructose (HF) diet (57.1% w/w). Five-week-old male Sprague-Dawley rats were fed a HF diet to induce glucose intolerance and hyperlipidemia. The experiment was divided into three groups: (1) control diet group (Con); (2) HF diet group (HF); and (3) HF with GA diet group (HF + 5% GA). The rats were fed the experimental diets and drinking water ad libitum for 23 weeks. The results showed that GA significantly decreased retroperitoneal fat mass weight of HF diet-fed rats...
July 2017: Journal of Food and Drug Analysis
https://www.readbyqxmd.com/read/28904260/impaired-%C3%AE-cell-function-and-decreased-insulin-sensitivity-in-subjects-with-normal-oral-glucose-tolerance-but-isolated-high-glycosylated-hemoglobin
#10
Qi Fu, Min Sun, Zhixiao Wang, Wei He, Yu Duan, Tao Yang
The pathophysiology is distinct in various state of glucose metabolism abnormalities. As the defect of individuals with normal oral glucose tolerance (NGT) but isolated high glycosylated hemoglobin (HbA1c), i.e. iHH, was ambiguous, we aimed to investigate the insulin sensitivity and β-cell function of iHH. According to the ADA criteria of HbA1c cut-off point (5.7%), 3,517 subjects with NGT screened from a total of 7,855 middle-aged and elderly Chinese without known diabetes were divided into two groups, 1,877 subjects with HbA1c < 5...
September 13, 2017: Endocrine Journal
https://www.readbyqxmd.com/read/28903960/biomarkers-of-food-intake-and-nutrient-status-are-associated-with-glucose-tolerance-status-and-development-of-type-2-diabetes-in-older-swedish-women
#11
Otto Savolainen, Mads Vendelbo Lind, Göran Bergström, Björn Fagerberg, Ann-Sofie Sandberg, Alastair Ross
Background: Diet is frequently associated with both the development and prevention of type 2 diabetes (T2D), but there is a lack of objective tools for assessing the relation between diet and T2D. Biomarkers of dietary intake are unconfounded by recall and reporting bias, and using multiple dietary biomarkers could help strengthen the link between a healthy diet and the prevention of T2D.Objective: The objective of this study was to explore how diet is related to glucose tolerance status (GTS) and to future development of T2D irrespective of common T2D and cardiovascular disease risk factors by using multiple dietary biomarkers...
September 13, 2017: American Journal of Clinical Nutrition
https://www.readbyqxmd.com/read/28903724/resting-heart-rate-and-impaired-glucose-regulation-in-middle-aged-and-elderly-chinese-people-a-cross-sectional-analysis
#12
Zhen Yang, Weiwei Zhang, Lingfei Zhu, Ning Lin, Yixin Niu, Xiaoyong Li, Shuai Lu, Hongmei Zhang, Xuanchun Wang, Jie Wen, Guang Ning, Li Qin, Qing Su
BACKGROUND: Elevated resting heart rate (RHR) has been reported to be associated with metabolic syndrome and type 2 diabetes. The aim of this study was to explore whether a positive relationship exists between RHR and impaired glucose regulation (IGR) among middle-aged and older Chinese individuals. METHODS: We conducted a cross-sectional analysis that included a total of 9898 subjects (3194 men and 6704 women) in a Chinese population. The RHRs were derived from ECG recordings, and the subjects were stratified based on RHR quartiles...
September 13, 2017: BMC Cardiovascular Disorders
https://www.readbyqxmd.com/read/28901427/microrna%C3%A2-106b-regulates-skeletal-muscle-insulin-sensitivity-and-glucose-homeostasis-by-targeting-mitofusion%C3%A2-2
#13
Ying Zhang, Wei He, Yuan-Fu Gao, Zhong-Min Fan, Chun-Lin Gao, Zheng-Kun Xia
MicroRNA‑106b (miR‑106b) is reported to be closely associated with skeletal muscle insulin resistance. The present study further investigated the role of miR‑106b in skeletal muscle insulin sensitivity and glucose homeostasis in vivo. Mice were randomly divided into 4 groups and infected with lentivirus expressing miR‑106b (miR‑106b mice), miR‑106b sponge (miR‑106b inhibition mice) or the corresponding empty vectors. Mitofusion‑2 (Mfn2) protein expression levels and glucose transporter (Glut)‑4 protein translocation were significantly reduced in the muscle of miR‑106b mice, whereas they were unaffected in miR‑106b inhibition mice...
September 8, 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/28899903/socs3-expression-in-sf1-cells-regulates-adrenal-differentiation-and-exercise-performance
#14
João Ab Pedroso, Pedro Omori Ribeiro de Mendonça, Marco As Fortes, Igor Tomaz, Vitor L Pecorali, Thais B Auricino, Ismael C Costa, Leandro B Lima, Isadora C Furigo, Debora N Bueno, Angela M Ramos-Lobo, Claudimara Ferini Pacicco Lotfi, Jose Donato
Many hormones/cytokines are secreted in response to exercise and cytokine signaling may play a pivotal role in the training adaptations. To investigate the importance of cytokine signaling during vertical ladder climbing, a resistance exercise model, we produced mice lacking SOCS3 protein exclusively in steroidogenic factor-1 (SF1) cells (SF1 Socs3 KO mice). SF1 expression is found in steroidogenic cells of the adrenal cortex and gonads, as well as in neurons of the ventromedial nucleus of the hypothalamus...
September 12, 2017: Journal of Endocrinology
https://www.readbyqxmd.com/read/28898202/toll-like-receptor-4-tlr4-deficient-mice-are-protected-from-adipose-tissue-inflammation-in-aging
#15
Amiya K Ghosh, Martin O'Brien, Theresa Mau, Raymond Yung
Adipose tissue (AT) inflammation is a central mechanism for metabolic dysfunction in both diet-induced obesity and age-associated obesity. Studies in diet-induced obesity have characterized the role of Fetuin A (Fet A) in Free Fatty Acids (FFA)-mediated TLR4 activation and adipose tissue inflammation. However, the role of Fet A & TLR4 in aging-related adipose tissue inflammation is unknown. In the current study, analysis of epidymymal fat pads of C57/Bl6 male mice, we found that, in contrast to data from diet-induced obesity models, adipose tissue from aged mice have normal Fet A and TLR4 expression...
September 7, 2017: Aging
https://www.readbyqxmd.com/read/28887312/increased-lipolysis-diminished-adipose-tissue-insulin-sensitivity-and-impaired-%C3%AE-cell-function-relative-to-adipose-tissue-insulin-sensitivity-in-obese-youth-with-impaired-glucose-tolerance-igt
#16
Joon Young Kim, Alexis Nasr, Hala Tfayli, Fida Bacha, Sara F Michaliszyn, Silva Arslanian
Despite evidence of insulin resistance and β-cell dysfunction in glucose metabolism in youth with prediabetes, the relationship between adipose tissue insulin sensitivity (ATIS) and β-cell function remains unknown. We investigated whole-body lipolysis, ATIS and β-cell function relative to ATIS [adipose disposition index (DI)] in obese youth with IGT vs. normal glucose tolerance (NGT). Whole-body lipolysis (glycerol appearance rate [GlyRa] ([(2)H5]glycerol at baseline and during a hyperinsulinemic-euglycemic clamp)), lipid oxidation (indirect calorimetry), insulin secretion (2-hr hyperglycemic clamp), and body composition (DEXA) were examined...
September 8, 2017: Diabetes
https://www.readbyqxmd.com/read/28887047/peptides-from-frog-skin-with-potential-for-development-into-agents-for-type-2-diabetes-therapy
#17
J Michael Conlon, Milena Mechkarska, Yasser H Abdel-Wahab, Peter R Flatt
Several frog skin peptides, first identified as result of their antimicrobial or immunomodulatory activities, have subsequently been shown to stimulate insulin release both in vitro and in vivo and so show potential for development into incretin-based drugs for treatment of patients with Type 2 diabetes mellitus. However, their therapeutic potential as anti-diabetic agents is not confined to this activity as certain frog skin-derived peptides, such as magainin-AM2 and CPF-SE1 and analogs of hymenochirin-1B, tigerinin-1R, and esculentin-2CHa, have been shown to increase insulin sensitivity, promote β-cell proliferation, suppress pancreatic and circulating glucagon concentrations, improve the lipid profile, and selectively alter expression of genes involved in insulin secretion and action in mice with diet-induced obesity, insulin resistance and impaired glucose tolerance...
September 5, 2017: Peptides
https://www.readbyqxmd.com/read/28886024/clomiphene-citrate-effect-in-obese-men-with-low-serum-testosterone-treated-with-metformin-due-to-dysmetabolic-disorders-a-randomized-double-blind-placebo-controlled-study
#18
Carla Pelusi, Vito Angelo Giagulli, Margherita Baccini, Flaminia Fanelli, Marco Mezzullo, Alessia Fazzini, Nicola Bianchi, Matteo Domenico Carbone, Giovanni De Pergola, Marianna Mastroroberto, Antonio Maria Morselli Labate, Renato Pasquali
CONTEXT: Low testosterone (T) levels are often found in obese men with impaired glucose tolerance (IGT) and overt type 2 diabetes (T2DM); however, the mechanisms underlying this condition and its correct therapy are still under debate. OBJECTIVE: To evaluate the effectiveness of clomiphene citrate (CC) in increasing endogenous T levels in obese men with low serum T and with IGT or T2DM treated with metformin (MET). DESIGN: Cross-over, randomized, double-blind, placebo-controlled study...
2017: PloS One
https://www.readbyqxmd.com/read/28884590/galacto-oligosaccharides-ameliorate-dysbiotic-bifidobacteriaceae-decline-in-japanese-patients-with-type-2-diabetes
#19
M Gonai, A Shigehisa, I Kigawa, K Kurasaki, O Chonan, T Matsuki, Y Yoshida, M Aida, K Hamano, Y Terauchi
Gut microbiota affects the host's metabolism, and it is suggested that there are differences in gut microbiota composition between patients with type 2 diabetes and healthy individuals. Additionally, dysbiosis may increase the concentration of lipopolysaccharides (LPS), causing metabolic endotoxemia, which induces impaired glucose tolerance. Several studies have reported relationships between metabolic diseases and the gut microbiota; and prebiotics, such as oligosaccharides, are commonly consumed to regulate gut microbiotas in healthy individuals...
September 8, 2017: Beneficial Microbes
https://www.readbyqxmd.com/read/28883393/fas-cell-surface-death-receptor-controls-hepatic-lipid-metabolism-by-regulating-mitochondrial-function
#20
Flurin Item, Stephan Wueest, Vera Lemos, Sokrates Stein, Fabrizio C Lucchini, Rémy Denzler, Muriel C Fisser, Tenagne D Challa, Eija Pirinen, Youngsoo Kim, Silvio Hemmi, Erich Gulbins, Atan Gross, Lorraine A O'Reilly, Markus Stoffel, Johan Auwerx, Daniel Konrad
Nonalcoholic fatty liver disease is one of the most prevalent metabolic disorders and it tightly associates with obesity, type 2 diabetes, and cardiovascular disease. Reduced mitochondrial lipid oxidation contributes to hepatic fatty acid accumulation. Here, we show that the Fas cell surface death receptor (Fas/CD95/Apo-1) regulates hepatic mitochondrial metabolism. Hepatic Fas overexpression in chow-fed mice compromises fatty acid oxidation, mitochondrial respiration, and the abundance of mitochondrial respiratory complexes promoting hepatic lipid accumulation and insulin resistance...
September 7, 2017: Nature Communications
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