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Impaired fasting glucose

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https://www.readbyqxmd.com/read/28213385/effectiveness-of-acarbose-in-treating-elderly-patients-with-diabetes-with-postprandial-hypotension
#1
Jie Zhang, Lixin Guo
: : Postprandial hypotension (PPH) is a common condition that occurs primarily in elderly patients with type 2 diabetes mellitus (T2DM). This study aimed to assess the effectiveness of acarbose for PPH; it also investigated possible mechanisms behind PPH development. This single-blind, randomized controlled trial included 91 elderly patients with T2DM, aged between 60 and 80 years, who were inpatients at Beijing Hospital between March 2012 and November 2014. The patients were included into one of three groups: Group A, patients with T2DM without PPH; Group B, patients with T2DM with PPH receiving placebo; and Group C, patients with T2DM with PPH receiving acarbose...
February 17, 2017: Journal of Investigative Medicine: the Official Publication of the American Federation for Clinical Research
https://www.readbyqxmd.com/read/28213373/cost-effectiveness-of-the-2014-u-s-preventive-services-task-force-uspstf-recommendations-for-intensive-behavioral-counseling-interventions-for-adults-with-cardiovascular-risk-factors
#2
Ji Lin, Xiaohui Zhuo, Barbara Bardenheier, Deborah B Rolka, W Edward Gregg, Yuling Hong, Guijing Wang, Ann Albright, Ping Zhang
OBJECTIVE: In 2014, the U.S. Preventive Services Task Force (USPSTF) recommended behavioral counseling interventions for overweight or obese adults with the following known cardiovascular disease risk factors: impaired fasting glucose (IFG), hypertension, dyslipidemia, or metabolic syndrome. We assessed the long-term cost-effectiveness (CE) of implementing the recommended interventions in the U.S. RESEARCH DESIGN AND METHODS: We used a disease progression model to simulate the 25-year CE of the USPSTF recommendation for eligible U...
February 17, 2017: Diabetes Care
https://www.readbyqxmd.com/read/28209453/-detection-and-classification-of-chronic-kidney-disease-in-primary-care-and-importance-of-albuminuria
#3
P J Labrador, S González-Sanchidrián, S Polanco, E Davin, J M Fuentes, J R Gómez-Martino
INTRODUCTION: Chronic kidney disease (CKD) is a public health problem, and Primary Care (PC) plays a key role in its detection and classification based on estimated glomerular filtration rate (eGFR), as well as the level of albuminuria for its proper management. The aim of this study was to analyse the prevalence and classification of CKD in patients attended in PC. MATERIAL AND METHODS: An analysis was made of CKD prevalence and classification according to the Kidney Disease-Improving Global Outcomes guidelines in PC patients...
February 13, 2017: Semergen
https://www.readbyqxmd.com/read/28203358/the-renal-effects-of-sglt2-inhibitors-and-a-mini-review-of-the-literature
#4
REVIEW
Vasileios Andrianesis, Spyridoula Glykofridi, John Doupis
Sodium-glucose linked transporter 2 (SGLT2) inhibitors are a new and promising class of antidiabetic agents which target renal tubular glucose reabsorption. Their action is based on the blockage of SGLT2 sodium-glucose cotransporters that are located at the luminal membrane of tubular cells of the proximal convoluted tubule, inducing glucosuria. It has been proven that they significantly reduce glycated hemoglobin (HbA1c), along with fasting and postprandial plasma glucose in patients with type 2 diabetes mellitus (T2DM)...
December 2016: Therapeutic Advances in Endocrinology and Metabolism
https://www.readbyqxmd.com/read/28202029/sustained-diabetes-risk-reduction-after-real-life-and-primary-health-care-setting-implementation-of-the-diabetes-in-europe-prevention-using-lifestyle-physical-activity-and-nutritional-intervention-de-plan-project
#5
Aleksandra Gilis-Januszewska, Jaana Lindström, Jaakko Tuomilehto, Beata Piwońska-Solska, Roman Topór-Mądry, Zbigniew Szybiński, Markku Peltonen, Peter E H Schwarz, Adam Windak, Alicja Hubalewska-Dydejczyk
BACKGROUND: Real life implementation studies performed in different settings and populations proved that lifestyle interventions in prevention of type 2 diabetes can be effective. However, little is known about long term results of these translational studies. Therefore, the purpose of this study was to examine the maintenance of diabetes type 2 risk factor reduction achieved 1 year after intervention and during 3 year follow-up in primary health care setting in Poland. METHODS: Study participants (n = 262), middle aged, slightly obese, with increased type 2 diabetes risk ((age 55...
February 15, 2017: BMC Public Health
https://www.readbyqxmd.com/read/28192530/non-enzymatic-glucosylation-induced-neo-epitopes-on-human-serum-albumin-a-concentration-based-study
#6
Km Neelofar, Zarina Arif, Jamal Ahmad, Khursheed Alam
Hyperglycaemia induced non enzymatic glycation is accelerated in diabetic patients and aggressively involved in diabetes progression. Human serum albumin (HSA) is the most abundant protein in blood circulation. In hyperglycaemia, it undergoes fast glycation and results in the impairment of structure. Our previous study has demonstrated structural alterations in Amadori-albumin modified with different glucose concentrations from physiological to pathophysiological range. Here, we focused on immunological characterization of Amadori-albumin...
2017: PloS One
https://www.readbyqxmd.com/read/28190874/maternal-consumption-of-a-cafeteria-diet-during-lactation-in-rats-leads-the-offspring-to-a-thin-outside-fat-inside-phenotype
#7
C A Pomar, R van Nes, J Sánchez, C Picó, J Keijer, A Palou
BACKGROUND AND OBJECTIVE: The suckling period is a critical phase of development, in which maternal over-nutrition may program the susceptibility of developing chronic diseases and disorders, such as obesity and metabolic alterations, in adult life. Here, we questioned whether the consumption of a cafeteria diet throughout lactation in rats affects the macronutrient composition of milk and whether it results in permanent metabolic effects in the offspring. METHODS: Nursing rats were fed a control diet or a cafeteria diet during lactation...
February 13, 2017: International Journal of Obesity: Journal of the International Association for the Study of Obesity
https://www.readbyqxmd.com/read/28188956/the-neural-substrate-of-gait-and-executive-function-relationship-in-elderly-women-a-pet-study
#8
Ryota Sakurai, Kenji Ishii, Masashi Yasunaga, Rumi Takeuchi, Yoh Murayama, Naoko Sakuma, Muneyuki Sakata, Keiichi Oda, Kenji Ishibashi, Kiichi Ishiwata, Yoshinori Fujiwara, Manuel Montero-Odasso
AIM: Understanding the relationship between age-related gait impairment, such as slow gait, and executive functioning in seniors may help identify individuals at higher risk of mobility decline, falls, and progression to dementia at earlier stages. We aim to identify brain regions concomitantly associated with poor gait and executive functioning in a cohort of well-functioning elderly women. METHODS: In total, 149 well-functioning women aged 70.1 ± 6.2 years underwent FDG-PET to evaluate regional cerebral metabolic rates of glucose normalized in reference to cerebellar glucose metabolic value (normalized-rCMRglc) in 16 brain areas...
February 11, 2017: Geriatrics & Gerontology International
https://www.readbyqxmd.com/read/28185532/the-metabolites-in-peripheral-blood-mononuclear-cells-showed-greater-differences-between-patients-with-impaired-fasting-glucose-or-type-2-diabetes-and-healthy-controls-than-those-in-plasma
#9
Minjoo Kim, Minkyung Kim, Ji Yun Han, Sang-Hyun Lee, Sun Ha Jee, Jong Ho Lee
To determine differences between peripheral blood mononuclear cells and the plasma metabolites in patients with impaired fasting glucose or type 2 diabetes and healthy controls. In all, 65 nononobese patients (aged 30-70 years) with impaired fasting glucose or type 2 diabetes and 65 nonobese sex-matched healthy controls were included, and fasting peripheral blood mononuclear cell and plasma metabolomes were profiled. The diabetic or impaired fasting glucose patients showed higher circulating and peripheral blood mononuclear cell lipoprotein phospholipase A2 activities, high-sensitivity C-reactive protein and tumour necrosis factor-α than controls...
March 2017: Diabetes & Vascular Disease Research
https://www.readbyqxmd.com/read/28183816/two-weeks-of-moderate-intensity-continuous-training-but-not-high-intensity-interval-training-increases-insulin-stimulated-intestinal-glucose-uptake
#10
Kumail Kumar Motiani, Anna M Savolainen, Jari-Joonas Eskelinen, Jussi Toivanen, Tamiko Ishizu, Minna Yli-Karjanmaa, Kirsi A Virtanen, Riitta Parkkola, Jukka Kapanen, Tove J Gronroos, Merja Haaparanta-Solin, Olof Solin, Nina Savisto, Markku Ahotupa, Eliisa Löyttyniemi, Juhani Knuuti, Pirjo Nuutila, Kari K Kalliokoski, Jarna C Hannukainen
Similar to muscles, the intestine is also insulin resistant in obese subjects and subjects with impaired glucose tolerance. Exercise training improves muscle insulin sensitivity, but its effects on intestinal metabolism are not known. We studied the effects of high intensity interval training (HIIT) and moderate intensity continuous training (MICT) on intestinal glucose and free fatty acid uptake from circulation in humans. Twenty-eight healthy middle-aged sedentary men were randomized for two weeks of HIIT or MICT...
February 9, 2017: Journal of Applied Physiology
https://www.readbyqxmd.com/read/28182280/anti-prediabetic-effect-of-rose-hip-rosa-canina-extract-in-spontaneously-diabetic-torii-rats
#11
Si Jing Chen, Chiwa Aikawa, Risa Yoshida, Tomoaki Kawaguchi, Toshiro Matsui
BACKGROUND: Prediabetes, a high-risk state for developing diabetes showing impaired glucose tolerance but normal fasting blood glucose level, has increasing prevalence worldwide. However, no study to prevent impaired glucose tolerance at prediabetic stage by anti-diabetic functional foods has been reported. Thus, the aim of the present study was to evaluate the anti-prediabetic effect of rose hip in a prediabetic rat model. RESULTS: Spontaneously Diabetic Torii (SDT) rats were supplemented with hot-water extract of rose hip at a dose of 100 mg/kg body weight/day for 12 weeks...
February 9, 2017: Journal of the Science of Food and Agriculture
https://www.readbyqxmd.com/read/28182146/multiple-diabetic-complications-as-well-as-impaired-physical-and-mental-function-are-associated-with-declining-balance-function-in-older-persons-with-diabetes-mellitus
#12
Xiufang Hong, Xujiao Chen, Jiaojiao Chu, Shanshan Shen, Qichen Chai, Gaobo Lou, Lingyan Chen
OBJECTIVE: To investigate whether there is a difference in balance function between older persons with and without diabetes mellitus (DM), and to identify whether mediating factors, such as diabetic complications, Instrumental Activities of Daily Living (IADL) score, Mini-Mental State Examination (MMSE) score, as well as hemoglobin A1c (HbA1c), fasting plasma glucose (FPG), serum total cholesterol (TC), triglycerides (TG), and low-density lipoprotein (LDL), are associated with balance function in older persons with DM...
2017: Clinical Interventions in Aging
https://www.readbyqxmd.com/read/28178143/healthy-lifestyle-and-normal-waist-circumference-are-associated-with-a-lower-5-year-risk-of-type-2-diabetes-in-middle-aged-and-elderly-individuals-results-from-the-healthy-aging-longitudinal-study-in-taiwan-halst
#13
Chu-Chih Chen, Kiang Liu, Chih-Chen Hsu, Hsing-Yi Chang, Hsiao-Chun Chung, Jih-Shin Liu, Yo-Hann Liu, Tsung-Lung Tsai, Wen-Jin Liaw, I-Ching Lin, Hsi-Wen Wu, Chung-Chou Juan, Hou-Chang Chiu, Marion M Lee, Chao A Hsiung
Type 2 diabetes mellitus (DM) is known to be closely associated with lifestyle and obesity and has a prevalence that increases with age. This study aimed to assess the short-term composite effect of diet, physical activity, psychosocial health, and waist circumference (WC) on the incidence of DM in the elderly and to provide a lifestyle-based predictive index.We used baseline measurements (2009-2013) of 5349 community-dwelling participants (aged 55 years and older, 52% female) of the Healthy Aging Longitudinal Study in Taiwan (HALST) for fasting plasma glucose, HbA1C, serum cholesterol, triglycerides, blood pressures, WC, and outcomes of home-visit questionnaire...
February 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28162947/fty720-supplementation-partially-improves-erectile-dysfunction-in-rats-with-streptozotocin-induced-type-1-diabetes-through-inhibition-of-endothelial-dysfunction-and-corporal-fibrosis
#14
Kai Cui, Yajun Ruan, Tao Wang, Ke Rao, Zhong Chen, Shaogang Wang, Jihong Liu
INTRODUCTION: Erectile dysfunction (ED) in patients with diabetes mellitus (DM) seriously affects their quality of life. However, these patients show a poor effect rate for oral phosphodiesterase type 5 inhibitors. Thus, new treatment methods are urgently needed. Fingolimod hydrochloride (FTY720) was approved in 2010 for the treatment of patients with the relapsing-remitting form of multiple sclerosis. AIM: To investigate whether FTY720 supplementation could ameliorate ED induced by DM (DMED)...
February 2, 2017: Journal of Sexual Medicine
https://www.readbyqxmd.com/read/28160451/association-between-carotid-intima-media-thickness-and-fasting-blood-glucose-level-a-population-based-cross-sectional-study-among-low-income-adults-in-rural-china
#15
Liu Gao, Lingling Bai, Min Shi, Jingxian Ni, Hongyan Lu, Yanan Wu, Jun Tu, Xianjia Ning, Jinghua Wang, Yukun Li
AIMS: Carotid intima-media thickness (CIMT) is an established predictor of cardiovascular disease and stroke. We aimed to identify the association between CIMT and blood glucose as well as the risk factors associated with increased CIMT in a low-income Chinese population. MATERIALS AND METHODS: Stroke-free and cardiovascular disease-free residents aged ≥45 years were recruited. B-mode ultrasonography was performed to measure CIMT. RESULTS: There were 2643 participants (71...
February 3, 2017: Journal of Diabetes Investigation
https://www.readbyqxmd.com/read/28152105/prevalence-and-determinants-of-non-alcoholic-fatty-liver-disease-in-lifelines-a-large-dutch-population-cohort
#16
Eline H van den Berg, Marzyeh Amini, Tim C M A Schreuder, Robin P F Dullaart, Klaas Nico Faber, Behrooz Z Alizadeh, Hans Blokzijl
BACKGROUND & AIMS: Non-alcoholic fatty liver disease is an increasing health issue that develops rather unnoticed with obesity, type 2 diabetes mellitus and metabolic syndrome. We investigated prevalence, determinants and associated metabolic abnormalities of non-alcoholic fatty liver disease in the largest population-based cohort to date. METHODS: Biochemical characteristics, type 2 diabetes mellitus and metabolic syndrome were determined in the Lifelines Cohort Study (N = 167,729), a population-based cohort in the North of the Netherlands...
2017: PloS One
https://www.readbyqxmd.com/read/28151855/serum-uromodulin-is-associated-with-impaired-glucose-metabolism
#17
Andreas Leiherer, Axel Muendlein, Christoph H Saely, Elena Kinz, Eva M Brandtner, Peter Fraunberger, Heinz Drexel
Uromodulin is the most abundant urine protein under physiological conditions. It has recently been described as a serum and plasma marker for kidney disease. Whether uromodulin is associated with impaired glucose metabolism is unknown.We therefore measured serum uromodulin and glucose traits in a cohort of 529 consecutively recruited patients.Serum uromodulin was significantly and inversely correlated with fasting plasma glucose (r = -0.161; P < 0.001), with plasma glucose 2 hours after an oral 75 g glucose challenge (r = -0...
February 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28149010/association-of-interleukin-6-and-myeloperoxidase-with-insulin-resistance-in-impaired-fasting-glucose-subjects
#18
Ashish Agarwal, Anupama Hegde, Charu Yadav, Afzal Ahmad, Poornima Ajay Manjrekar, Rukmini Mysore Srikantiah
Impaired fasting glucose (IFG) is a high risk subclinical condition for the progression of type 2 diabetes mellitus and the hyperglycemia seen in this condition is because of the development of insulin resistance (IR). Obesity, inflammation, oxidative stress and many other factors have been implicated in development of IR in type 2 diabetes mellitus and its successive complications. Current study was aimed to ascertain the correlation of inflammation and oxidative stress markers [interleukin-6 (IL-6) and myeloperoxidase (MPO)] with IR in subjects with IFG...
March 2017: Indian Journal of Clinical Biochemistry: IJCB
https://www.readbyqxmd.com/read/28146431/association-of-plasma-ghrelin-levels-and-ghrelin-rs4684677-polymorphism-with-mild-cognitive-impairment-in-type-2-diabetic-patients
#19
Rong Huang, Jing Han, Sai Tian, Rongrong Cai, Jie Sun, Yanjue Shen, Shaohua Wang
BACKGROUND AND AIMS: People with insulin resistance and type 2 diabetes mellitus (T2DM) are at increased risks of cognitive impairment. We aimed to investigate the association of plasma ghrelin levels and ghrelin rs4684677 polymorphism with mild cognitive impairment (MCI) in T2DM patients. RESULTS: In addition to elevated glycosylated hemoglobin (HbA1c), fasting blood glucose (FBG) and homeostasis model assessment of insulin resistance (HOMA-IR), T2DM patients with MCI had decreased plasma ghrelin levels compared with their healthy-cognition subjects (all p < 0...
January 27, 2017: Oncotarget
https://www.readbyqxmd.com/read/28144712/peripheral-insulin-resistance-rather-than-beta-cell-dysfunction-accounts-for-geographical-differences-in-impaired-fasting-blood-glucose-among-sub-saharan-african-individuals-findings-from-the-rodam-study
#20
Karlijn A C Meeks, Karien Stronks, Adebowale Adeyemo, Juliet Addo, Silver Bahendeka, Erik Beune, Ellis Owusu-Dabo, Ina Danquah, Cecilia Galbete, Peter Henneman, Kerstin Klipstein-Grobusch, Frank P Mockenhaupt, Kwame Osei, Matthias B Schulze, Joachim Spranger, Liam Smeeth, Charles Agyemang
AIMS/HYPOTHESIS: The aim of this study was to assess the extent to which insulin resistance and beta cell dysfunction account for differences in impaired fasting blood glucose (IFBG) levels in sub-Saharan African individuals living in different locations in Europe and Africa. We also aimed to identify determinants associated with insulin resistance and beta cell dysfunction among this population. METHODS: Data from the cross-sectional multicentre Research on Obesity and Diabetes among African Migrants (RODAM) study were analysed...
January 31, 2017: Diabetologia
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