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Hemoglobin A1c

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https://www.readbyqxmd.com/read/29452335/change-in-cardiometabolic-risk-among-blacks-whites-and-hispanics-findings-from-the-health-and-retirement-study
#1
Uchechi A Mitchell, Jennifer A Ailshire, Eileen M Crimmins
Background: Blacks experience greater multi-system physiological dysregulation, or cumulative biological risk, which is associated with poor cardiometabolic health and mortality. In this study, we assess race differences in change in risk over four years among older whites, blacks and Hispanics. Method: We examined race differences in 4-year change in individual biomarkers and a cumulative measure of risk-cardiometabolic risk (CMR)-using data for each respondent from two waves of the Health and Retirement Study's biomarker assessment (n=5,512)...
February 14, 2018: Journals of Gerontology. Series A, Biological Sciences and Medical Sciences
https://www.readbyqxmd.com/read/29450720/diabetic-kidney-disease-is-there-a-role-for-glycemic-variability
#2
REVIEW
Savitha Subramanian, Irl B Hirsch
PURPOSE OF REVIEW: Diabetes is the leading cause of kidney disease globally. Diabetic kidney disease (DKD) is a heterogeneous disorder manifested as albuminuria and/or decreasing GFR. Hyperglycemic burden is the major contributor to the development of DKD. In this article, we review the evidence for the contribution of glycemic variability and the pitfalls associated with use of hemoglobin A1c (A1C), the gold standard for assessment of glucose control, in the setting of DKD. RECENT FINDINGS: Glycemic variability, characterized by swings in blood glucose levels, can result in generation of mitochondrial reactive oxygen species, a putative inciting factor for hyperglycemia-induced alterations in intracellular metabolic pathways...
February 15, 2018: Current Diabetes Reports
https://www.readbyqxmd.com/read/29450684/application-and-impact-of-run-in-studies
#3
Michael Fralick, Jerry Avorn, Jessica M Franklin, Abdurrahman Abdurrob, Aaron S Kesselheim
BACKGROUND: A run-in phase is often employed prior to randomization in a clinical trial to exclude non-adherent patients, placebo responders, active drug non-responders, or patients who do not tolerate the active drug. This may impact the generalizability of trial results. OBJECTIVE: To determine if clinical outcomes differed between randomized controlled trials with run-in phases compared with randomized controlled trials of the same medication without run-in phases...
February 15, 2018: Journal of General Internal Medicine
https://www.readbyqxmd.com/read/29449958/a-mobile-phone-based-program-to-promote-healthy-behaviors-among-adults-with-prediabetes-study-protocol-for-a-pilot-randomized-controlled-trial
#4
Dina H Griauzde, Jeffrey T Kullgren, Brad Liestenfeltz, Caroline Richardson, Michele Heisler
Background: Rates of participation in Diabetes Prevention Programs (DPPs) are low. This may be due, in part, to low levels of autonomous motivation (i.e., motivation that arises from internal sources and sustains healthy behaviors over time) to prevent type 2 diabetes (T2DM) among many individuals with prediabetes. Mobile health (mHealth) technologies that incorporate principles from the Self-Determination Theory offer an effective and scalable approach to increase autonomous motivation levels...
2018: Pilot and Feasibility Studies
https://www.readbyqxmd.com/read/29449096/evaluating-the-impact-of-diabetes-self-management-education-methods-on-knowledge-attitudes-and-behaviours-of-adult-patients-with-type-2-diabetes-mellitus
#5
Laura Adam, Colleen O'Connor, Alicia C Garcia
OBJECTIVES: Diabetes self-management refers to all activities patients undertake to care for their illness, promote health and prevent the long- and short-term effects of diabetes. This study compared the effectiveness of 2 diabetes self-management education methods by examining changes in glycated hemoglobin (A1C) levels and knowledge, attitudes and behaviours (KABs) after traditional group education (TE) or with diabetes conversation maps (CMs). The CMs group was postulated to show greater decrease in A1C levels and improved KABs scores compared to the TE group...
November 23, 2017: Canadian Journal of Diabetes
https://www.readbyqxmd.com/read/29447347/cultural-adaptation-of-an-evidence-based-lifestyle-intervention-for-diabetes-prevention-in-chinese-women-at-risk-for-diabetes-results-of-a-randomized-trial
#6
Zenong Yin, Judith Perry, Xiaoqin Duan, Meizi He, Ryan Johnson, Yanling Feng, Mark Strand
Background: The prevalence of both obesity and type 2 diabetes has been on the rise in China. This randomized controlled trial was conducted to test the feasibility and effectiveness of an evidence-based diabetes prevention program in Yuci, Shanxi Province, China from 2012 to 2014. Methods: Women with pre-diabetes, ages 25-65 y, were assigned randomly to a comparison (n=75) or 6-mo lifestyle intervention condition (n=109). Weight, fasting glucose, hemoglobin A1c and self-reported diet and physical activity were measured at baseline, 6 mo and 12 mo...
February 13, 2018: International Health
https://www.readbyqxmd.com/read/29446529/educational-disparities-in-the-associations-between-self-monitoring-of-blood-glucose-and-glycemic-control-in-type-2-diabetes-patients-in-xiamen-china
#7
Yanbing Zeng, Jielong Wu, Yaofeng Han, Fan Chen, Lele Chen, Shuyu Yang, Ya Fang
BACKGROUND: To examine the combined effect of self-monitoring of blood glucose (SMBG) and educational attainment on glycemic control in type 2 diabetes mellitus (T2DM) patients. METHODS: A cross-sectional survey was performed among community residents with T2DM. Good glycemic control was defined as hemoglobin A1c (HbA1c) levels below 7% in the most recent measurement. Multivariable logistic regression was used to examine associations of glycemic control with SMBG, educational attainment, and their combined effects by controlling for certain covariates, with further stratification by sex...
February 15, 2018: Journal of Diabetes
https://www.readbyqxmd.com/read/29446333/delays-in-seeking-general-medical-services-and-measurable-abnormalities-among-individuals-with-serious-mental-illness
#8
Stanislav Spivak, Bernadette A Cullen, William Eaton, Katie L Nugent, Katrina Rodriguez, Ramin Mojtabai
OBJECTIVE: The study explored the association of delays in seeking general medical care with elevated blood pressure and metabolic abnormalities among individuals with serious mental illness. METHODS: Association of delays in medical care with blood pressure, serum hemoglobin A1c (HbA1C), and lipids was assessed among patients at two inner-city community mental health centers. RESULTS: Of 271 participants, 62% reported delays in seeking general medical care due to attitudinal and financial barriers...
February 15, 2018: Psychiatric Services: a Journal of the American Psychiatric Association
https://www.readbyqxmd.com/read/29443437/influencing-pathways-to-quality-of-life-and-hba1c-in-patients-with-diabetes-a-longitudinal-study-that-inform-evidence-based-practice
#9
Hui-Chun Hsu, Yau-Jiunn Lee, Ruey-Hsia Wang
BACKGROUND: Determining possible associated factors and the influencing pathways to hemoglobin A1C (HbA1C) levels and quality of life (QoL) will facilitate the development of effective interventions to improve the physical and psychosocial health of patients with type 2 diabetes mellitus (T2DM). OBJECTIVES: To test a hypothesized model that addressed the pathways among personal characteristics, social support, diabetes distress, and self-care behaviors to HbA1C and QoL...
February 14, 2018: Worldviews on Evidence-based Nursing
https://www.readbyqxmd.com/read/29441711/effects-of-residential-summer-camp-on-body-mass-index-and-body-composition-in-type-1-diabetes
#10
Jon D Oden, Brian Franklin, Ernesto Fernandez, Soumya Adhikari, Perrin C White
BACKGROUND: Body mass index (BMI) and fat mass may be higher in children with diabetes compared to healthy peers. It is not certain how diabetic children respond to exercise and diet interventions. OBJECTIVE: To investigate the effect of summer camp on BMI and body composition in children with type 1 diabetes. METHODS: Five hundred eighty-six children (5-19 years, 518 with type 1 diabetes, 68 without diabetes) were followed while attending camp...
February 13, 2018: Pediatric Diabetes
https://www.readbyqxmd.com/read/29437648/cardiovascular-outcomes-associated-with-canagliflozin-versus-other-non-gliflozin-antidiabetic-drugs-population-based-cohort-study
#11
Elisabetta Patorno, Allison B Goldfine, Sebastian Schneeweiss, Brendan M Everett, Robert J Glynn, Jun Liu, Seoyoung C Kim
OBJECTIVE: To evaluate the cardiovascular safety of canagliflozin, a sodium-glucose cotransporter 2 inhibitor for the treatment of type 2 diabetes mellitus, in direct comparisons with DPP-4 inhibitors (DPP-4i), GLP-1 receptor agonists (GLP-1RA), or sulfonylureas, as used in routine practice. DESIGN: Population based retrospective cohort study. SETTING: Nationwide sample of patients with type 2 diabetes from a large de-identified US commercial healthcare database (Optum Clinformatics Datamart)...
February 6, 2018: BMJ: British Medical Journal
https://www.readbyqxmd.com/read/29437531/improving-population-health-among-uninsured-patients-with-diabetes
#12
Michele H Talley, Shea Polancich, Jason B Williamson, Jennifer S Frank, William Curry, John F Russell, Cynthia Selleck
Diabetes is a leading cause of morbidity and mortality; prevalence of diabetes is especially high in the southeastern United States among minority populations and those from lower socioeconomic sectors without access to health care services. The purpose of this project was to evaluate the clinical and financial outcomes of a nurse-led, interprofessional collaborative practice model that provides care coordination and transitional care for uninsured patients with diabetes. Data for this study were collected and evaluated from medical records of patients seen at the Providing Access to Health Care (PATH) Clinic between August 1, 2015, through May 30, 2017...
February 13, 2018: Population Health Management
https://www.readbyqxmd.com/read/29437292/non-high-density-lipoprotein-cholesterol-to-high-density-lipoprotein-cholesterol-ratio-is-an-independent-risk-factor-for-diabetes-mellitus-results-from-a-population-based-cohort
#13
Nan Zhang, Xiang Hu, Qiao Zhang, Peng Bai, Miao Cai, Tian Shu Zeng, Jiao-Yue Zhang, Sheng-Hua Tian, Jie Min, Han-Tao Huang, Juan Zheng, Miao-Miao Peng, Meng-Jiao Li, Lu-Lu Chen
BACKGROUND: Dyslipidemia predicts development and progression of diabetes. Higher non-high-density lipoprotein cholesterol to high-density lipoprotein cholesterol ratio (nonHDL-C/HDL-C) was reported to be associated with metabolic syndrome and insulin resistance in previous studies, but its relationship with glycemic levels and diabetes remains unclear. This study aimed to investigate the association of nonHDL-C/HDL-C with diabetes and to evaluate stability of this relationship in different subgroups...
February 13, 2018: Journal of Diabetes
https://www.readbyqxmd.com/read/29437243/melatonin-attenuates-smoking-induced-hyperglycemia-via-preserving-insulin-secretion-and-hepatic-glycogen-synthesis-in-rats
#14
Tianjia Li, Leng Ni, Zhewei Zhao, Xinnong Liu, Zhichao Lai, Xiao Di, Zhibo Xie, Xitao Song, Xuebin Wang, Rui Zhang, Changwei Liu
Epidemiology survey indicated that cigarette smoking is a risk factor of diabetes. However, the precise mechanisms remain to be clarified. In the current study, we found that smoking caused metabolic malfunctions on pancreas and liver in experimental animal model. These were indicated by hyperglycemia, increased serum hemoglobin A1c level and decreased insulin secretion, inhibition of liver glycogen synthase (LGS) and hepatic glycogen synthesis. Mechanistic studies revealed that all these alterations were caused by the inflammatory reaction and reactive oxygen species (ROS) induced by the smoking...
February 13, 2018: Journal of Pineal Research
https://www.readbyqxmd.com/read/29435911/efficacy-of-a-telephone-based-intervention-among-patients-with-type-2-diabetes-a-randomized-controlled-trial-in-pharmacy-practice
#15
Amir Sarayani, Mojgan Mashayekhi, Marzieh Nosrati, Zahra Jahangard-Rafsanjani, Mohammadreza Javadi, Navid Saadat, Sheyda Najafi, Kheirollah Gholami
Background Pharmacists' interventions to improve outcomes of diabetes management have been promising. However, evidence on using telephone-based interventions in pharmacy practice are limited, particularly in developing countries. Objective To evaluate the efficacy of a telephone-based intervention to improve care and clinical outcomes in type-2 diabetes. Setting A referral community pharmacy and drug information center. Method We conducted a two-armed randomized controlled trial on 100 patients with type-2 diabetes...
February 12, 2018: International Journal of Clinical Pharmacy
https://www.readbyqxmd.com/read/29435776/effect-of-anagliptin-and-sitagliptin-on-low-density-lipoprotein-cholesterol-in-type-2-diabetic-patients-with-dyslipidemia-and-cardiovascular-risk-rationale-and-study-design-of-the-reason-trial
#16
Shinichiro Ueda, Michio Shimabukuro, Osamu Arasaki, Koichi Node, Takashi Nomiyama, Takeshi Morimoto
BACKGROUND: Reduction of low-density lipoprotein cholesterol (LDL-C) is important for patients with a high risk for atherosclerotic events, such as patients with diabetes and other risk factors. Anagliptin was reported to reduce LDL-C for 12 weeks in phase III trials regardless of the use of statins, but it is uncertain whether this effect is common to other dipeptidylpeptidase-4 (DPP-4) inhibitors. METHODS: A multicenter, randomized, open-label, parallel-group trial was conducted to confirm the superiority of anagliptin to sitagliptin in terms of the primary endpoint of reduction of LDL-C for 52 weeks in patients with type 2 diabetes and atherosclerotic vascular lesions, as well as the non-inferiority of anagliptin to sitagliptin in terms of change in hemoglobin A1c (HbA1c)...
February 12, 2018: Cardiovascular Drugs and Therapy
https://www.readbyqxmd.com/read/29431598/momordica-charantia-administration-improves-insulin-secretion-in-type-2-diabetes-mellitus
#17
Marisol Cortez-Navarrete, Esperanza Martínez-Abundis, Karina G Pérez-Rubio, Manuel González-Ortiz, Miriam Méndez-Del Villar
An improvement in parameters of glycemic control has been observed with Momordica charantia in patients with type 2 diabetes mellitus (T2DM). It is unknown whether this improvement is through a modification of insulin secretion, insulin sensitivity, or both. We hypothesized that M. charantia administration can improve insulin secretion and/or insulin sensitivity in patients with T2DM, without pharmacological treatment. The objective of the study was to evaluate the effect of M. charantia administration on insulin secretion and sensitivity...
February 12, 2018: Journal of Medicinal Food
https://www.readbyqxmd.com/read/29429611/associations-of-multiple-plasma-metals-with-incident-type-2-diabetes-in-chinese-adults-the-dongfeng-tongji-cohort
#18
Yu Yuan, Yang Xiao, Yanqiu Yu, Yiyi Liu, Wei Feng, Gaokun Qiu, Hao Wang, Bing Liu, Jing Wang, Lue Zhou, Kang Liu, Xuedan Xu, Handong Yang, Xiulou Li, Lu Qi, Xiaomin Zhang, Meian He, Frank B Hu, An Pan, Tangchun Wu
The long-term associations between multiple metals and incident diabetes are uncertain. We aimed to examine the relationship between plasma concentrations of 23 metals and the incidence of type 2 diabetes among Chinese senior adults. We quantified fasting plasma concentrations of 23 metals by inductively coupled plasma mass spectrometry among 1039 incident diabetes cases and 1039 controls (age and sex matched) nested in a prospective study, the Dongfeng-Tongji cohort. Both cases and controls were free of diabetes at baseline (2008-2010), incident diabetes were identified using the following criteria: fasting glucose ≥ 7...
February 8, 2018: Environmental Pollution
https://www.readbyqxmd.com/read/29429532/vitamin-k-2-alleviates-type-2-diabetes-in-rats-by-induction-of-osteocalcin-gene-expression
#19
Atef G Hussein, Randa H Mohamed, Sally M Shalaby, Dalia M Abd El Motteleb
OBJECTIVES: The biological mechanisms behind the association between vitamin K (Vit K) and glucose metabolism are uncertain. We aimed to analyze the expression of insulin 1 (Ins 1), insulin 2 (Ins 2) and cyclin D2, the expression of adiponectin and UCP-1 . In addition, we aimed to estimate the doses of Vit K2 able to affect various aspects of glucose and energy metabolism in type 2 diabetes. METHODS: Thirty adult male rats were allocated equally into five groups: control group, diabetes mellitus group, and groups 3, 4, and 5, which received Vit K 2 at three daily dose levels (10, 15, and 30 mg/kg, respectively) for 8 wk...
March 2018: Nutrition
https://www.readbyqxmd.com/read/29429256/-prevalence-and-risk-factors-of-diabetic-retinopathy-in-hospital-patients
#20
Y Zhang, M Niu, Y Li, J Wang, B Qu, C X Zheng, P Huang, W H Yu
Objective: To analyze the prevalence and risk factors of diabetic retinopathy (DR) in ophthalmic patients. Methods: A cross-sectional study was performed. Diabetic patients who were admitted to Department of Ophthalmology, Traditional Chinese Medicine Hospital of Muping between October 2012 and June 2013 were included. General information and medical history were obtained from each subject by questionaires. Laboratory and detailed ophthalmic examinations were performed during the study. DR was diagnosed and graded by mydriatic fundus photography...
February 6, 2018: Zhonghua Yi Xue za Zhi [Chinese medical journal]
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