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Hemoglobin A1c

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https://www.readbyqxmd.com/read/29239249/the-association-of-perioperative-glycemic-control-with-postoperative-surgical-site-infection-following-open-carpal-tunnel-release-in-patients-with-diabetes
#1
Brian C Werner, Victor A Teran, Jourdan Cancienne, D Nicole Deal
BACKGROUND: The primary goal of the study was to evaluate the association of hemoglobin A1c (HbA1c) levels in diabetic patients with the incidence of surgical site infection (SSI) following open carpal tunnel release (CTR). Our secondary objective was to calculate an HbA1c level in diabetic patients that predicted SSI after open CTR. METHODS: A national private-payer insurance database was queried for patients who underwent open CTR using Current Procedural Terminology (CPT) code 64721...
December 1, 2017: Hand: Official Journal of the American Association for Hand Surgery
https://www.readbyqxmd.com/read/29238876/independent-association-between-prediabetes-and-future-pancreatic-fat-accumulation-a-5-year-japanese-cohort-study
#2
Hajime Yamazaki, Shinichi Tauchi, Miho Kimachi, Mitsuru Dohke, Nagisa Hanawa, Yoshihisa Kodama, Akio Katanuma, Yosuke Yamamoto, Shunichi Fukuhara, Shingo Fukuma
BACKGROUND: The association between pancreatic fat and glucose dysmetabolism has been reported in several cross-sectional studies; however, a recent longitudinal study showed that baseline pancreatic fat did not cause subsequent diabetes mellitus. We hypothesized that pancreatic fat is not a cause but a manifestation of glucose dysmetabolism and aimed to investigate the association between baseline prediabetes and future pancreatic fat accumulation. METHODS: Between 2008 and 2015, 198 nondiabetic participants, who underwent a health check-up via unenhanced computed tomography (CT) twice with CT intervals ≥ 5 years, were enrolled as prediabetes (n = 48) and non-prediabetes participants (n = 150)...
December 13, 2017: Journal of Gastroenterology
https://www.readbyqxmd.com/read/29238650/identification-of-the-joint-effect-of-a-dynamic-treatment-intervention-and-a-stochastic-monitoring-intervention-under-the-no-direct-effect-assumption
#3
Romain Neugebauer, Julie A Schmittdiel, Alyce S Adams, Richard W Grant, Mark J van der Laan
The management of chronic conditions is characterized by frequent re-assessment of therapy decisions in response to the patient's changing condition over the course of the illness. Evidence most suitable to inform care thus often concerns the contrast of adaptive treatment strategies that repeatedly personalize treatment decisions over time using the latest accumulated data available from the patient's previous clinic visits such as laboratory exams (e.g., hemoglobin A1c measurements in diabetes care). The frequency at which such information is monitored implicitly defines the causal estimand that is typically evaluated in an observational or randomized study of such adaptive treatment strategies...
January 2017: Journal of Causal Inference
https://www.readbyqxmd.com/read/29237302/the-hypoglycemic-and-antioxidant-activities-of-garden-cress-lepidium-sativum-l-seed-on-alloxan-induced-diabetic-male-rats
#4
Eman S Attia, Afaf H Amer, Manal A Hasanein
The hypoglycemic and antioxidants activities of the methanol extract of Lepidium sativum seeds was tested in alloxan-induced diabetic male rats. Thirty male albino rats weighing 190-200 g were divided into five groups as follows: negative control, positive control and three diabetic groups treated with three concentrations of L. sativum methanol extract for four weeks. Induction of hyperglycemia in the positive control group increased blood glucose, glycated hemoglobin A1c, immunoglobulins, liver enzyme, lipid peroxide and kidney function, total cholesterol, low-density lipoproteins, very low-density lipoproteins and decreased antioxidants and high-density lipoproteins compared with the negative control...
December 13, 2017: Natural Product Research
https://www.readbyqxmd.com/read/29231052/efficacy-and-safety-of-ranolazine-in-diabetic-patients-a-systematic-review-and-meta-analysis
#5
Xiaofang Zeng, Yinyin Zhang, Jianhui Lin, Haikuo Zheng, Jie Peng, Wei Huang
BACKGROUND: Recent studies have discovered that the antiangina agent ranolazine exerts a glucometabolic effect. OBJECTIVE: This systematic review and meta-analysis aimed to further understand the efficacy and safety profile of ranolazine in patients with diabetes. METHODS: Randomized controlled trials (RCTs) were searched in PubMed, Cochrane, and EMBASE databases and in ClinicalTrials.gov up to July 2017. Efficacy end points were defined as the change in hemoglobin A1C (A1C) and fasting serum glucose (FSG) levels...
December 1, 2017: Annals of Pharmacotherapy
https://www.readbyqxmd.com/read/29230299/predictors-of-acute-gastrointestinal-bleeding-in-diabetic-ketoacidosis-a-retrospective-observational-study-in-minority-population
#6
Kanthi Rekha Badipatla, Preeti Jadhav, Sushma Vaddigiri, Bharat Bajantri, Amandeep Singh, Chaitanya Chandrala, Vijay S Are, Suresh Kumar Nayudu
Background: Diabetic ketoacidosis (DKA) is a common acute complication of diabetes mellitus requiring aggressive medical management. We attempted to study the incidence and various clinical and laboratory variables associated with acute gastrointestinal bleeding (AGIB) and acute upper AGIB (AUGIB) in patients with DKA. Methods: We conducted a retrospective chart review of all the patients admitted to our hospital with DKA between January 2010 and December 2015. We collected demographic, clinical, laboratory, endoscopy and hospitalization details using an electronic medical-record database...
November 2017: Gastroenterology Report
https://www.readbyqxmd.com/read/29228348/flaxseed-supplementation-on-glucose-control-and-insulin-sensitivity-a-systematic-review-and-meta-analysis-of-25-randomized-placebo-controlled-trials
#7
Mohsen Mohammadi-Sartang, Zahra Sohrabi, Reza Barati-Boldaji, Hamidreza Raeisi-Dehkordi, Zohreh Mazloom
Context: The results of human clinical trials investigating the effects of flaxseed on glucose control and insulin sensitivity are inconsistent. Objective: The present study aimed to systematically review and analyze randomized controlled trials assessing the effects of flaxseed consumption on glycemic control. Data Sources: PubMed, Medline via Ovid, SCOPUS, EMBASE, and ISI Web of Sciences databases were searched up to November 2016. Study Selection: Clinical trials in which flaxseed or its products were administered as an intervention were included...
December 8, 2017: Nutrition Reviews
https://www.readbyqxmd.com/read/29227039/mid-term-results-of-bariatric-surgery-in-morbidly-obese-japanese-patients-with-slow-progressive-autoimmune-diabetes
#8
Kohei Uno, Yosuke Seki, Kazunori Kasama, Kotaro Wakamatsu, Kenkichi Hashimoto, Akiko Umezawa, Katsuhiko Yanaga, Yoshimochi Kurokawa
INTRODUCTION: Bariatric surgery is recognized as an effective treatment for type 2 diabetes mellitus, but data on its efficacy for type 1 diabetes mellitus, especially slowly progressive insulin-dependent diabetes mellitus, are limited. METHODS: We investigated five Japanese patients with slowly progressive insulin-dependent diabetes mellitus who underwent bariatric surgery at our center. RESULTS: Five morbidly obese glutamic acid decarboxylase antibody-positive diabetic patients underwent two different types of bariatric surgery...
December 11, 2017: Asian Journal of Endoscopic Surgery
https://www.readbyqxmd.com/read/29226659/performance-evaluation-of-the-bio-rad-d-100-system-for-hemoglobin-a1c-assay
#9
Tae-Dong Jeong, Sholhui Park, Ki-Sook Hong
No abstract text is available yet for this article.
November 1, 2017: Clinical Laboratory
https://www.readbyqxmd.com/read/29226203/blood-glucose-levels-in-diabetic-patients-following-corticosteroid-injections-into-the-subacromial-space-of-the-shoulder
#10
Alexander W Aleem, Usman Ali M Syed, Thema Nicholson, Charles L Getz, Surena Namdari, Pedro K Beredjiklian, Joseph A Abboud
Background: Corticosteroid injections are used to treat a variety of orthopedic conditions with the goal of decreasing pain and inflammation. Administration of systemic or local corticosteroids risks temporarily increasing blood glucose levels, especially diabetic patients. The purpose of this study is to quantify the effects of corticosteroid injections on blood glucose levels in diabetic patients with shoulder pathology. Methods: Diabetic patients who regularly monitored their blood glucose levels and were indicated for a subacromial corticosteroid injection were included in this prospective investigation...
September 2017: Archives of Bone and Joint Surgery
https://www.readbyqxmd.com/read/29225893/a-novel-approach-to-glycemic-control-in-type-2-diabetes-mellitus-partial-jejunal-diversion-pre-clinical-to-clinical-pathway
#11
Martin Fried, Karin Dolezalova, Adam P Chambers, Elliott J Fegelman, Robin Scamuffa, Michael L Schwiers, Jason R Waggoner, Martin Haluzik, Randy J Seeley
Objective: To explore partial jejunal diversion (PJD) via a side-to-side jejuno-jejunostomy for improved glycemic control in type 2 diabetes mellitus (T2DM). PJD is an anatomy-sparing, technically simple surgery in comparison to the predominate metabolic procedures, Roux-en-Y gastric bypass (RYGB) and sleeve gastrectomy (SG). Positive results in a rodent model prompted a human proof-of-concept study. Research design and methods: Pre-clinically, 71 rats were studied in a model of metabolic dysfunction induced by a high-fat diet; 33 animals undergoing one of two lengths of PJD were compared with 18 undergoing sham, 10 RYGB and 10 jejuno-ileal bypass...
2017: BMJ Open Diabetes Research & Care
https://www.readbyqxmd.com/read/29225702/the-influence-of-dopamine-beta-hydroxylase-and-catechol-o-methyltransferase-gene-polymorphism-on-the-efficacy-of-insulin-detemir-therapy-in-patients-with-type-2-diabetes-mellitus
#12
Tomislav Bozek, Antonela Blazekovic, Matea Nikolac Perkovic, Kristina Gotovac Jercic, Aleksandra Sustar, Lea Smircic-Duvnjak, Tiago F Outeiro, Nela Pivac, Fran Borovecki
Background: Type II diabetes is an important health problem with a complex connection to obesity, leading to a broad range of cardiovascular complications. Insulin therapy often results in weight gain and does not always ensure adequate glycemic control. However, previous studies reported that insulin detemir is an efficient long-acting insulin with a weight sparing effect. The aim of this study was to determine the association of catechol O-methyltransferase (COMT) Val108/158Met and dopamine-beta-hydroxylase (DBH) 1021C/T polymorphisms with the effectiveness of insulin detemir in achieving glucose control and body weight control...
2017: Diabetology & Metabolic Syndrome
https://www.readbyqxmd.com/read/29225483/active-stromal-cell-derived-factor-1%C3%AE-and-endothelial-progenitor-cells-are-equally-increased-by-alogliptin-in-good-and-poor-diabetes-control
#13
Roberto Negro, Eupremio Luigi Greco, Giacomo Greco
Background: It is postulated that the ability of dipeptidyl peptidase-4 inhibitors (DPP-4-i) to increase circulating endothelial progenitor cells (EPCs) may be at least partly mediated by active stromal cell-derived factor 1α (SDF-1α) (a pivotal mediator of stem cell mobilization from the bone marrow). As other DPP-4-i were demonstrated to increase EPC concentrations, in this study, we sought to investigate the ability of the DPP-4-i alogliptin in modifying EPCs and SDF-1α, in patients with good and poor diabetes control...
2017: Clinical Medicine Insights. Endocrinology and Diabetes
https://www.readbyqxmd.com/read/29225209/dapagliflozin-reduces-fat-mass-without-affecting-muscle-mass-in-type-2-diabetes
#14
Seigo Sugiyama, Hideaki Jinnouchi, Noboru Kurinami, Kunio Hieshima, Akira Yoshida, Katsunori Jinnouchi, Hiroyuki Nishimura, Tomoko Suzuki, Fumio Miyamoto, Keizo Kajiwara, Tomio Jinnouchi
AIM: Sodium-glucose co-transporter 2 inhibitor (SGLT2i) therapy has been demonstrated to improve glycemic control and reduce body weight and fat mass in type 2 diabetes mellitus (T2DM). Here, our aim was to investigate the effects of SGLT2i dapagliflozin-treatment on body muscle mass and muscle fat content in patients with T2DM. METHODS: We prospectively recruited uncontrolled (hemoglobin A1c [HbA1c] >7%) Japanese T2DM patients who had a body mass index (BMI) <35 kg/m2...
December 8, 2017: Journal of Atherosclerosis and Thrombosis
https://www.readbyqxmd.com/read/29224636/effects-of-pharmacy-based-interventions-on-the-control-and-management-of-diabetes-in-adults-a-systematic-review-and-meta-analysis
#15
REVIEW
Mohsen Yaghoubi, Kerry Mansell, Hassanali Vatanparastc, Megan Steeves, Wu Zeng, Marwa Farag
OBJECTIVES: The aim of this systematic review and meta-analysis was to evaluate the effects of pharmacy-based interventions on clinical outcomes associated with diabetes-related complications as well as on nonclinical outcomes in people with diabetes. METHODS: We searched 4 main databases (MEDLINE, EMBASE, CINAHL and Cochrane Central Register of Controlled Trials) for studies that considered clinical and nonclinical outcomes of pharmacy-based interventions among people with diabetes...
December 2017: Canadian Journal of Diabetes
https://www.readbyqxmd.com/read/29223225/poor-glycemic-control-as-a-risk-factor-for%C3%A2-pseudophakic-cystoid-macular-edema-in-patients-with-diabetes
#16
Petteri Ylinen, Ilkka Laine, Juha-Matti Lindholm, Raimo Tuuminen
PURPOSE: To specify the risk factors for pseudophakic cystoid macular edema (CME) in patients with diabetes. SETTING: Kymenlaakso Central Hospital, Unit of Ophthalmology, Kotka, Finland. DESIGN: Prospective case series. METHODS: Patients with type 1 or type 2 diabetes having routine cataract surgery were evaluated. Spectral-domain optical coherence tomography imaging was performed before surgery and 1 month postoperatively...
November 2017: Journal of Cataract and Refractive Surgery
https://www.readbyqxmd.com/read/29220533/androgens-irregular-menses-and-risk-of-diabetes-and-coronary-artery-calcification-in-the-diabetes-prevention-program
#17
Catherine Kim, Vanita R Aroda, Ronald B Goldberg, Naji Younes, Sharon L Edelstein, MaryLou Carrion-Petersen, David A Ehrmann
Context: It is unclear whether relative elevations in androgens or irregular menses (IM) are associated with greater cardiometabolic risk among women who are already overweight and glucose intolerant. Research Design and Methods: We conducted a secondary analysis of Diabetes Prevention Program (DPP) and the DPP Outcomes Study (DPPOS). Participants included women with sex hormone measurements who did not use exogenous estrogen (n=1422). We examined whether free androgen index (FAI) or IM were associated with diabetes risk during the DPP/DPPOS or with coronary artery calcification (CAC) at DPPOS year 10...
December 6, 2017: Journal of Clinical Endocrinology and Metabolism
https://www.readbyqxmd.com/read/29218837/asthma-in-children-and-adolescents-with-type-1-diabetes-in-germany-and-austria-frequency-and-metabolic-control
#18
Thomas Hörtenhuber, Wieland Kiess, Elke Fröhlich-Reiterer, Klemens Raile, Rainer Stachow, Esther Bollow, Birgit Rami-Merhar, Reinhard W Holl
OBJECTIVE: To investigate the prevalence of asthma in young patients with type 1 diabetes mellitus (T1D) from Austria and Germany and its influence on their metabolic control. METHODS: This prospective, multicenter observational cohort study was based on the DPV-registry (German/Austrian DPV initiative) including 51 926 patients with T1D (<20 years). All clinical data were documented prospectively. To identify patients with additional asthma, the entry of the diagnosis asthma as well as asthma medication was used for classification...
December 8, 2017: Pediatric Diabetes
https://www.readbyqxmd.com/read/29218018/aerobic-interval-training-and-cardiometabolic-health-in-patients-with-type-2-diabetes-a-meta-analysis
#19
Shanhu Qiu, Xue Cai, Zilin Sun, Martina Zügel, Jürgen M Steinacker, Uwe Schumann
Vigorous to maximal aerobic interval training (INT) has received remarkable interest in improving cardiometabolic outcomes for type 2 diabetes patients recently, yet with inconsistent findings. This meta-analysis was aimed to quantify its effectiveness in type 2 diabetes. Randomized controlled trials (RCTs) were identified by searches of 3 databases to October 2017, which evaluated the effects of INT with a minimal training duration of 8 weeks vs. moderate-intensity continuous training (MICT) or non-exercise training (NET) among type 2 diabetes patients on outcomes including cardiorespiratory fitness, glycemic control, body composition, blood pressure, and lipid profiles...
2017: Frontiers in Physiology
https://www.readbyqxmd.com/read/29217148/ethnic-differences-in-the-prevalence-and-risk-factors-of-diabetic-retinopathy-the-singapore-epidemiology-of-eye-diseases-study
#20
Gavin S Tan, Alfred Gan, Charumathi Sabanayagam, Yih Chung Tham, Kumari Neelam, Paul Mitchell, Jie Jin Wang, Ecosse L Lamoureux, Ching-Yu Cheng, Tien Y Wong
PURPOSE: To evaluate the prevalence and risk factors for diabetic retinopathy (DR) in the Singapore Epidemiology of Eye Diseases (SEED) Study. DESIGN: Population-based, cross-sectional study. PARTICIPANTS: Persons of Malay, Indian, and Chinese ethnicity aged 40+ years, living in Singapore. METHODS: Diabetes was defined as nonfasting plasma glucose ≥200 mg/dl (11.1 mmol/l), glycated hemoglobin A1c (HbA1c) >6.5%, self-reported physician-diagnosed diabetes, or the use of glucose-lowering medication...
December 4, 2017: Ophthalmology
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