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Hemoglobin A1c

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https://www.readbyqxmd.com/read/29055090/performance-of-nontraditional-hyperglycemia-biomarkers-by-chronic-kidney-disease-status-in-older-adults-with-diabetes-results-from-the-atherosclerosis-risk-in-communities-study
#1
Molly Jung, Bethany Warren, Morgan Grams, Yuenting Diana Kwong, Tariq Shafi, Josef Coresh, Casey M Rebholz, Elizabeth Selvin
BACKGROUND: In persons with chronic kidney disease (CKD), hemoglobin A1c (HbA1c) may be a problematic measure of glycemic control. Glycated albumin and fructosamine have been proposed as better markers of hyperglycemia in CKD. We investigated associations of HbA1c, glycated albumin, and fructosamine with fasting glucose by CKD categories. METHODS: Cross-sectional analysis of 1,665 Atherosclerosis Risk in Communities Study participants with diagnosed diabetes aged 65 years or older...
October 20, 2017: Journal of Diabetes
https://www.readbyqxmd.com/read/29054846/diabetes-and-ckd-in-the-united-states-population-2009-2014
#2
Leila R Zelnick, Noel S Weiss, Bryan R Kestenbaum, Cassianne Robinson-Cohen, Patrick J Heagerty, Katherine Tuttle, Yoshio N Hall, Irl B Hirsch, Ian H de Boer
BACKGROUND AND OBJECTIVES: Diabetes is an important cause of CKD. However, among people with diabetes, it is unclear to what extent CKD is attributable to diabetes itself versus comorbid conditions, such as advanced age and hypertension. We examined associations of diabetes with clinical manifestations of CKD independent of age and BP and the extent to which diabetes contributes to the overall prevalence of CKD in the United States. DESIGN, SETTING, PARTICIPANTS, & MEASUREMENTS: We performed a cross-sectional study of 15,675 participants in the National Health and Nutrition Examination Surveys from 2009 to 2014...
October 20, 2017: Clinical Journal of the American Society of Nephrology: CJASN
https://www.readbyqxmd.com/read/29054482/the-effectiveness-of-an-obstructive-sleep-apnea-screening-and-treatment-program-in-patients-with-type-2-diabetes
#3
Lucas M Donovan, Michael Rueschman, Jia Weng, Nisha Basu, Katherine A Dudley, Jessie P Bakker, Rui Wang, Suzanne M Bertisch, Sanjay R Patel
AIMS: As recommended by current guidelines, we tested the acceptability and impact of screening patients with type 2 diabetes for obstructive sleep apnea (OSA). METHODS: In a large urban primary care practice, we instituted a telephone-based OSA screening program using a validated tool (STOP-BANG) in patients with type 2 diabetes. Patients identified as high risk were referred for diagnostic sleep testing, and those diagnosed with OSA were offered positive airway pressure (PAP) therapy...
October 17, 2017: Diabetes Research and Clinical Practice
https://www.readbyqxmd.com/read/29051912/evaluating-diabetes-care-for-patients-with-serious-mental-illness-using-the-chronic-care-model-a-pilot-study
#4
Kelly Vaez, Lauren Diegel-Vacek, Catherine Ryan, Pamela Martyn-Nemeth
People with serious mental illness (SMI) have a higher incidence of type 2 diabetes mellitus (T2DM) and shorter life span due to medical health problems. The chronic care model (CCM) has been used to improve care of patients with T2DM. One clinical organization that provided primary care to patients with SMI had excellent diabetes outcomes but did not have information on how they achieved those outcomes. Thus, we conducted a pilot study chart review for 30 patients with T2DM and SMI to determine how well the clinic's system aligned with the overall CCM components and which components correlated with diabetes control...
January 2017: Health Services Research and Managerial Epidemiology
https://www.readbyqxmd.com/read/29050321/interaction-among-cyp2c8-gpiiia-and-p2y12-variants-increase-susceptibility-to-ischemic-stroke-in-chinese-population
#5
Xingyang Yi, Jing Lin, Yanfen Wang, Ju Zhou, Qiang Zhou
PURPOSE: Genetic variants in cytochrome P450 (CYP), platelet membrane receptor (P2Y12, P2Y1), and glycoprotein IIIa (GPIIIa) genes are associated with the efficacy of clopidogrel and adverse clinical events on ischemic stroke (IS) patients. However, few studies have assessed whether gene-gene interactions among these genes influence the risk of IS. The aim of the present study was to investigate the association of fifteen variants with IS and to determine whether these gene-gene interactions increase the risk of IS...
September 19, 2017: Oncotarget
https://www.readbyqxmd.com/read/29049639/oral-hypoglycemic-agents-added-to-insulin-monotherapy-for-type-2-diabetes
#6
Rimke C Vos, Guy E H M Rutten
Clinical Question: Among patients with type 2 diabetes mellitus who do not achieve optimal glycemic control with insulin monotherapy, is the addition of oral hypoglycemic agents associated with benefits (measured by lowering of hemoglobin A1c) or adverse effects? Bottom Line: Adding a sulfonylurea to insulin was associated with more hypoglycemic events compared with insulin alone, but this association was not observed for metformin. Adding a sulfonylurea or metformin to insulin was associated with a decrease in hemoglobin A1c of approximately 1...
October 17, 2017: JAMA: the Journal of the American Medical Association
https://www.readbyqxmd.com/read/29049180/the-effect-of-care-intervention-for-obese-patients-with-type-ii-diabetes
#7
Xuelian Jiang, Xiyun Fan, Rui Wu, Fengqin Geng, Chenping Hu
The incidence of type II diabetes mellitus (T2DM) is increasing worldwide and affecting the quality of people's life. This study was designed to evaluate the effect of care intervention on body weight and glycemic parameters in obese T2DM patients.One hundred twenty-six obese T2DM cases were randomly divided into 2 groups. Patients in control group received conventional care, while patients in the intervention group received dietary, exercise, and psychology interventions on the basis of conventional care. Twelve months follow-up was performed to compare the changes of body weight and glycemic parameters in the 2 groups...
October 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29047239/a-gender-specific-association-between-self-reported-snoring-and-hemoglobin-a1c-levels-in-a-general-population-without-type-2-diabetes-mellitus
#8
Young Hoon Lee, Sun Seog Kweon, Jin Su Choi, Hae Sung Nam, Kyeong Soo Park, Seong Woo Choi, Su Hyun Oh, Sun A Kim, Min Ho Shin
PURPOSE: We explored whether a gender difference was evident in terms of the associations of snoring with hemoglobin A1c (HbA1c) and homeostatic model assessment-insulin resistance (HOMA-IR) levels in a healthy population without type 2 diabetes mellitus (DM). MATERIALS AND METHODS: We analyzed 2706 males and 4080 females who participated in the baseline survey of the Namwon Study. In terms of self-reported snoring frequency, participants were classified as non-snorers or occasional (1-3 days/week), frequent (4-6 days/week), or constant (7 days/week) snorers...
November 2017: Yonsei Medical Journal
https://www.readbyqxmd.com/read/29044720/observational-comparative-effectiveness-of-pharmaceutical-treatments-for-obesity-within-the-veterans-health-administration
#9
Ted R Grabarczyk
STUDY OBJECTIVE: To compare the effectiveness of weight-management medications used to assist with weight loss in real-world clinical practice in the Veterans Health Administration (VHA). DESIGN: Retrospective, multicenter, observational cohort study. DATA SOURCE: National VA Corporate Data Warehouse. PATIENTS: A total of 66,035 VA patients aged 18 years or older with a body mass index of 25 kg/m(2) or greater who had an initial fill for a study medication (orlistat [6153 patients], phentermine [304 patients], lorcaserin [298 patients], or phentermine-topiramate extended release [233 patients]) or participation in the VA's MOVE! weight management program with at least three total visits in a clinic coded as a MOVE clinic in the subsequent 24 weeks (59,047 patients) between January 1, 2012 and July 1, 2016...
October 17, 2017: Pharmacotherapy
https://www.readbyqxmd.com/read/29043529/development-and-validation-of-a-risk-assessment-tool-for-gastric-cancer-in-a-general-japanese-population
#10
Masahiro Iida, Fumie Ikeda, Jun Hata, Yoichiro Hirakawa, Tomoyuki Ohara, Naoko Mukai, Daigo Yoshida, Koji Yonemoto, Motohiro Esaki, Takanari Kitazono, Yutaka Kiyohara, Toshiharu Ninomiya
BACKGROUND: There have been very few reports of risk score models for the development of gastric cancer. The aim of this study was to develop and validate a risk assessment tool for discerning future gastric cancer risk in Japanese. METHODS: A total of 2444 subjects aged 40 years or over were followed up for 14 years from 1988 (derivation cohort), and 3204 subjects of the same age group were followed up for 5 years from 2002 (validation cohort). The weighting (risk score) of each risk factor for predicting future gastric cancer in the risk assessment tool was determined based on the coefficients of a Cox proportional hazards model in the derivation cohort...
October 17, 2017: Gastric Cancer
https://www.readbyqxmd.com/read/29042694/immunohistochemistry-of-vasohibin-2-in-human-kidney-disease-implications-in-impaired-glucose-tolerance-and-reduced-renal-function
#11
Yuka Arata, Katsuyuki Tanabe, Norikazu Hinamoto, Hiroko Yamasaki, Hitoshi Sugiyama, Yohei Maeshima, Naoki Kanomata, Yasufumi Sato, Jun Wada
Several angiogenesis-related factors are known to play important roles in the pathogenesis of kidney disease. Vasohibin-2 (VASH-2) was recently reported as a novel proangiogenic factor. Although VASH-2 was demonstrated to accelerate tumor angiogenesis, its roles in non-tumor processes including renal disease have not been well elucidated yet. Here, we performed a retrospective study including an immunohistochemical analysis of human kidney biopsy specimens from 82 Japanese patients with a variety of kidney diseases, and we evaluated the correlations between the immunoreactivity of VASH-2 and the patients' clinicopathological parameters...
October 2017: Acta Medica Okayama
https://www.readbyqxmd.com/read/29041003/depression-in-the-context-of-medical-disorders-new-pharmacological-pathways-revisited
#12
Undine E Lang, Marc Walter
The depressive state has been characterised as one of elevated inflammation, changed cardiovascular parameters and a deranged metabolic situation all of which holds promise for a better understanding and handling of treatment-resistance in affective disorders as well as for future developments in treatment algorithms. In this context several biomarkers are differentially regulated by antidepressant treatment and connected to metabolic, inflammatory, cardiovascular and apoptotic components of the pathophysiology, i...
October 17, 2017: Neuro-Signals
https://www.readbyqxmd.com/read/29040204/perioperative-glycemic-control-and-postoperative-complications-in-patients-undergoing-emergency-general-surgery-what-is-the-role-of-hba1c
#13
Faisal Jehan, Muhammad Khan, Joseph V Sakran, Mohammad Khreiss, Terence O'Keeffe, Albert Chi, Narong Kulvatunyou, Arpana Jain, El Rasheid Zakaria, Bellal Joseph
BACKGROUND: Plasma Hemoglobin A1c (HbA1c) reflects quality of glucose control in diabetic patients. Literature reports that patients undergoing surgery with an elevated HbA1c level are associated with increased postoperative morbidity and mortality. The aim of our study was to evaluate the impact of HbA1c level on outcomes after emergency general surgery (EGS). METHODS: We performed a 3-year analysis of our prospectively maintained EGS database. Patients who had HbA1c levels measured within 3-months before surgery were included...
October 16, 2017: Journal of Trauma and Acute Care Surgery
https://www.readbyqxmd.com/read/29037572/gender-related-differences-in-the-control-of-cardiovascular-risk-factors-in-primary-care-for-elderly-patients-with-type-2-diabetes-a-cohort-study
#14
Abdallah Al-Salameh, Sophie Bucher, Bernard Bauduceau, Linda Benattar-Zibi, Gilles Berrut, Philippe Bertin, Emmanuelle Corruble, Nicolas Danchin, Geneviève Derumeaux, Jean Doucet, Bruno Falissard, Françoise Forette, Olivier Hanon, Rissane Ourabah, Florence Pasquier, Michel Pinget, Virginie Ringa, Laurent Becquemont
OBJECTIVE: The aim of this study was to estimate the association between gender and control of diabetes and other cardiovascular risk factors in elderly patients with type 2 diabetes mellitus. METHODS: The sujets âgés cohort is an observational study whose main objective was to describe the real-life management of elderly patients with type 2 diabetes mellitus in France. Nine hundred eighty-three patients with diabetes (517 men and 466 women) were recruited by 213 general practitioners and were followed up prospectively every 6 months for 3 years...
October 13, 2017: Canadian Journal of Diabetes
https://www.readbyqxmd.com/read/29035939/predictors-for-the-development-of-microalbuminuria-and-interaction-with-renal-function
#15
Christos Chatzikyrkou, Jan Menne, Joseph Izzo, Giancarlo Viberti, Ton Rabelink, Luis M Ruilope, Christian Rump, Peter R Mertens, Hermann Haller
AIM: It is important to know which factors predict the development of microalbuminuria in patients with diabetes mellitus type II. MATERIAL: Data from the Randomized Olmesartan and Diabetes Microalbuminuria Prevention Study were used to identify predictors for the new onset of microalbuminuria. Furthermore, the interaction of baseline albuminuria and baseline estimated glomerular filtration rate (eGFR) and the effects of treatment with olmesartan were investigated...
October 13, 2017: Journal of Hypertension
https://www.readbyqxmd.com/read/29035180/ten-year-trends-in-preventive-service-use-before-and-after-prostate-cancer-diagnosis-a-comparison-with-noncancer-controls
#16
Lauren P Wallner, Jeffrey M Slezak, Ronald K Loo, Roshan Bastani, Steven J Jacobsen
CONTEXT: Few studies have assessed the longer-term quality of preventive care in prostate cancer (PCa) survivors. OBJECTIVE: To compare the rates of preventive services among PCa survivors five years before and after diagnosis, to men without PCa. DESIGN: Men enrolled in Kaiser Permanente Southern California with newly diagnosed PCa (2002-2008) were matched 1:1 to men without a PCa diagnosis on age, race, and timing of prostate-specific antigen test (N = 31,180)...
2017: Permanente Journal
https://www.readbyqxmd.com/read/29034006/canagliflozin-reduces-epicardial-fat-in-patients-with-type-2-diabetes-mellitus
#17
Shusuke Yagi, Yukina Hirata, Takayuki Ise, Kenya Kusunose, Hirotsugu Yamada, Daiju Fukuda, Hotimah Masdan Salim, Gulinu Maimaituxun, Susumu Nishio, Yuriko Takagawa, Saori Hama, Tomomi Matsuura, Koji Yamaguchi, Takeshi Tobiume, Takeshi Soeki, Tetsuzo Wakatsuki, Ken-Ichi Aihara, Masashi Akaike, Michio Shimabukuro, Masataka Sata
BACKGROUND: It is unknown whether canagliflozin, a selective sodium glucose co-transporter 2 inhibitor, reduces epicardial adipose tissue (EAT) thickness, which is associated with insulin resistance and is a risk factor for coronary artery disease. METHODS AND RESULTS: We administered 100 mg of canagliflozin for 6 months to 13 patients with type 2 diabetes mellitus. We evaluated glycemic control, visceral adipose tissue (VAT) area and subcutaneous adipose tissue (SAT) area, and skeletal muscle mass by using impedance methods, and EAT thickness by using echocardiography...
2017: Diabetology & Metabolic Syndrome
https://www.readbyqxmd.com/read/29033310/relation-of-elevated-serum-uric-acid-levels-to-first-degree-heart-block-and-other-cardiac-conduction-defects-in-hospitalized-patients-with-type-2-diabetes
#18
Alessandro Mantovani, Riccardo Rigolon, Isabella Pichiri, Giovanni Morani, Stefano Bonapace, Clementina Dugo, Giacomo Zoppini, Enzo Bonora, Giovanni Targher
AIMS: Several studies have reported that moderately elevated serum uric acid levels are associated with an increased risk of tachyarrhythmias (mainly atrial fibrillation) in patients with and without type 2 diabetes mellitus (T2DM). It is currently unknown whether an association also exists between elevated serum uric acid levels and cardiac conduction defects in patients with T2DM. METHODS: We retrospectively analyzed a hospital-based sample of 967 patients with T2DM discharged from our Division of Endocrinology over the years 2007-2014...
September 20, 2017: Journal of Diabetes and its Complications
https://www.readbyqxmd.com/read/29032886/prevalence-and-risk-factors-for-paroxysmal-atrial-fibrillation-and-flutter-detection-after-cryptogenic-ischemic-stroke
#19
Claire Carrazco, Daniel Golyan, Michael Kahen, Karen Black, Richard B Libman, Jeffrey M Katz
INTRODUCTION: Long-term cardiac monitoring with implantable loop recorders (ILRs) has revealed occult paroxysmal atrial fibrillation and flutter (PAF) in a substantial minority of cryptogenic ischemic stroke (CIS) patients. Herein, we aim to define the prevalence, clinical relevance, and risk factors for PAF detection following early poststroke ILR implantation. MATERIALS AND METHODS: A retrospective study of CIS patients (n = 100, mean age 65.8 years; 52.5% female) who underwent ILR insertion during, or soon after, index stroke admission...
October 9, 2017: Journal of Stroke and Cerebrovascular Diseases: the Official Journal of National Stroke Association
https://www.readbyqxmd.com/read/29032139/effects-of-vildagliptin-on-ventricular-function-in-patients-with-type-2-diabetes%C3%A2-mellitus-and-heart-failure-a-randomized-placebo-controlled-trial
#20
John J V McMurray, Piotr Ponikowski, Geremia B Bolli, Valentina Lukashevich, Plamen Kozlovski, Wolfgang Kothny, James D Lewsey, Henry Krum
OBJECTIVES: This study sought to examine the safety of the dipeptidyl peptidase-4 inhibitor, vildagliptin, in patients with heart failure and reduced ejection fraction. BACKGROUND: Many patients with type 2 diabetes mellitus have heart failure and it is important to know about the safety of new treatments for diabetes in these individuals. METHODS: Patients 18 to 85 years of age with type 2 diabetes and heart failure (New York Heart Association functional class I to III and left ventricular ejection fraction [LVEF] <0...
October 11, 2017: JACC. Heart Failure
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